J. Kunitomo

发表

Design and synthesis of potent and selective pyridazin-4(1H)-one-based PDE10A inhibitors interacting with Tyr683 in the PDE10A selectivity pocket.

M. Yoshikawa, T. Hitaka, Tomoaki Hasui, 2016, Bioorganic & medicinal chemistry.

Synthesis, structure-activity relationship, and pharmacological studies of novel melanin-concentrating hormone receptor 1 antagonists 3-aminomethylquinolines: reducing human ether-a-go-go-related gene (hERG) associated liabilities.

J. Kunitomo, Masaharu Nakayama, Koki Kato, 2012, Journal of medicinal chemistry.

A novel glycogen synthase kinase‐3 inhibitor 2‐methyl‐5‐(3‐{4‐[(S )‐methylsulfinyl]phenyl}‐1‐benzofuran‐5‐yl)‐1,3,4‐oxadiazole decreases tau phosphorylation and ameliorates cognitive deficits in a transgenic model of Alzheimer’s disease

J. Kunitomo, M. Takizawa, E. Kimura, 2011, Journal of neurochemistry.

Discovery of spiropiperidine-based potent and selective Orexin-2 receptor antagonists.

J. Kunitomo, Tatsuhiko Fujimoto, Y. Tomata, 2011, Bioorganic & medicinal chemistry letters.

Design and synthesis of a novel series of orally active, selective somatostatin receptor 2 agonists for the treatment of type 2 diabetes.

J. Kunitomo, Masanori Watanabe, N. Amano, 2017, Bioorganic & medicinal chemistry.

Discovery of spiropiperidine-based potent and selective Orexin-2 receptor antagonists.

J. Kunitomo, Tatsuhiko Fujimoto, Y. Tomata, 2011, Bioorganic & medicinal chemistry letters.

Preparation of 2-, 3-, 4- and 7-(2-alkylcarbamoyl-1-alkylvinyl)benzo[b]furans and their BLT1 and/or BLT2 inhibitory activities.

J. Kunitomo, Y. Kawamura, T. Yokomizo, 2008, Organic & biomolecular chemistry.

Preparation of leukotriene B(4) inhibitory active 2- and 3-(2-aminothiazol-4-yl)benzo[b]furan derivatives and their growth inhibitory activity on human pancreatic cancer cells.

J. Kunitomo, I. Kawasaki, Y. Sakata, 2008, Organic & biomolecular chemistry.

Preparation of 3-(4-chlorophenyl)-2-(2-aminothiazol-4-yl)-5-methoxybenzo[b]furan derivatives and their leukotriene B(4) inhibitory activity.

J. Kunitomo, I. Kawasaki, Y. Sakata, 2007, Organic & biomolecular chemistry.

Preparation of 2- and 4-(2-alkylcarbamoyl-1-methylvinyl)-7-alkyloxybenzo[b]furans having potent antagonistic activity against human leukotriene B4 BLT1 and/or BLT2 receptors.

J. Kunitomo, Takao Shimizu, S. Kohno, 2004, Organic & biomolecular chemistry.

Red-emissive Mn-doped Li2Ge4O9 phase synthesized via glass-ceramic route

J. Kunitomo, T. Miyazaki, T. Fujiwara, 2014 .

Preparation of 3-acetoacetylaminobenzo[b]furan derivatives with cysteinyl leukotriene receptor 2 antagonistic activity.

J. Kunitomo, S. Kohno, M. Yamashita, 2003, Organic & biomolecular chemistry.

2-{3-[4-(Alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta with good brain permeability.

J. Kunitomo, Toshimasa Tanaka, C. Mol, 2009, Journal of medicinal chemistry.

Design, synthesis and structure-activity relationships of 1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta.

J. Kunitomo, Toshimasa Tanaka, C. Mol, 2009, Bioorganic & medicinal chemistry.

STRUCTURE OF MENISPORPHINE : A NEW TYPE OF ISOQUINOLINE ALKALOID

J. Kunitomo, M. Satoh, 1982 .

Discovery of potent, selective, orally active benzoxazepine-based Orexin-2 receptor antagonists.

J. Kunitomo, K. Nishiyama, K. Hirai, 2011, Bioorganic & medicinal chemistry letters.

[The alkaloids of Stephania cepharantha Hayata cultivated in Japan (ii) (author's transl)].

J. Kunitomo, M. Akasu, M. Oshikata, 1981, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Syntheses of 3-acetoacetylaminobenzo[b]furan derivatives having cysteinyl leukotriene 2 receptor antagonistic activity.

J. Kunitomo, S. Kohno, M. Yamashita, 2004, Organic & biomolecular chemistry.

Mutagenicity of isoquinoline alkaloids, especially of the aporphine type.

J. Kunitomo, S. Natori, H. Ishii, 1990, Mutation research.

[Synthesis of a few trimethoxyoxoaporphines (author's transl)].

J. Kunitomo, Y. Murakami, M. Sugisakon, 1979, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Variation of reaction channel in a flavoenzyme model with a modified pyrimidine ring

J. Kunitomo, A. Ohno, F. Yoneda, 1994 .

First example of "diastereotopic face activation" and chiral recognition without metal assistance. A novel 5-deazaflavin enzyme model.

J. Kunitomo, F. Yoneda, T. Kawamoto, 1992 .

Mn-doped LiNaGe 4 O 9 as a rare-earth free phosphor: impact of Na-substitution on emission in tetragermanate phase

J. Kunitomo, M. Osada, T. Fujiwara, 2015 .

Successive phase transformation in stoichiometric glassy Li2Ge4O9: Isothermal and nonisothermal study

J. Kunitomo, M. Osada, T. Miyazaki, 2013 .

Soft-phonon mode observation in Li2Ge4O9 phase above room temperature

J. Kunitomo, M. Osada, T. Fujiwara, 2012 .

ATRIPISOMERIC FLAVOENZYME MODELS WITH A MODIFIED PYRIMIDINE RING : SYNTHESES, PHYSICAL PROPERTIES, AND STEREOCHEMISTRY IN THE REACTIONS WITH NAD(P)H A NALOGS

J. Kunitomo, A. Ohno, F. Yoneda, 1996 .

[Studies on the alkaloids of menispermaceous plants. 186. Absolute configuration of biscoclaurine alkaloids. (1). O,O,N-Trimethylcoclaurine type alkaloids].

J. Kunitomo, M. Tomita, 1962, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Physical properties of atropisomeric 5-deazaflavin derivatives

J. Kunitomo, A. Ohno, Y. Kawai, 1997 .

Studies on the Alkaloids of Rutaceous Plants. VIII: Alkaloids of Phellodendron amurense RUPR. (3) Structure of Phellodendrine (ii)@@@キハダ Phellodendron amurense RUPR.のアルカロイドその3 Phellodendrineの構造 (ii)

J. Kunitomo, M. Tomita, 1960 .

Discovery of 1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (TAK-063), a highly potent, selective, and orally active phosphodiesterase 10A (PDE10A) inhibitor.

Hironori Kokubo, Makoto Fushimi, Kosuke Nakashima, 2014, Journal of medicinal chemistry.

Synthesis and biological activities of novel furo[2,3,4-jk][2]benzazepin-4(3H)-one derivatives.

J. Kunitomo, T. Yokomizo, T. Ohishi, 2007, Organic & biomolecular chemistry.

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by a progressive deterioration in cognitive function and memory and has two pathological hallmark lesions: senile plaques and neurofibrillary tangles (NFTs)

J. Kunitomo, M. Takizawa, E. Kimura, 2011 .

Clastogenicity of aporphine alkaloids in vitro.

J. Kunitomo, S. Yamada, A. Tanaka, 1992, Journal of pharmacobio-dynamics.

Structure and synthesis of menisporphine, a new type of isoquinoline alkaloid

J. Kunitomo, T. Shingu, M. Satoh, 1983 .

The Structure of 2, 3-Dihydromenisporphine and the Synthesis of Dauriporphine, Oxoisoaporphine Alkaloids from Menispermum dauricum DC.

J. Kunitomo, M. Satoh, S. Kaede, 1985 .

STUDIES ON THE ALKALOIDS OF MENISPERMACEOUS PLANTS. 279. ALKALOIDS OF MENISPERMUM DAURICUM DC. 9. STRUCTURE AND SYNTHESIS OF MENISPORPHINE, A NEW TYPE OF ISOQUINOLINE ALKALOID

J. Kunitomo, T. Shingu, M. Satoh, 1984 .

Design and synthesis of a novel 2-oxindole scaffold as a highly potent and brain-penetrant phosphodiesterase 10A inhibitor.

M. Yoshikawa, J. Kunitomo, H. Kokubo, 2015, Bioorganic & medicinal chemistry.

Application of INDOR and NOE Techniques to Determination of the Substitution Pattern on an Aromatic Ring of Erythrinan Alkaloids

J. Kunitomo, H. Furukawa, T. Shingu, 1978 .

Dihydroerysovine, a New Erythrina Alkaloid

J. Kunitomo, H. Furukawa, T. Shingu, 1977 .

[Studies on the alkaloids of rutaceous plants. XVII. Alkaloids of Phellodendron amurense Rupr. (7)].

J. Kunitomo, 1962, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Studies on the Alkaloids of Rutaceous Plants. XV: Alkaloids of Phellodendron amurense RUPR. var. japonicum OHWI. (1)@@@ケキハダ Phellodendron amurense RUPR. var. japonicum OHWIのアルカロイドその1

J. Kunitomo, 1961 .

Studies on the Alkaloids of Rutaceous Plants. IX: Alkaloids of Phellodendron amurense RUPR. (4). Synthesis of dl -Phellodendrine and its Isomers@@@キハダ Phellodendron amurense RUPR. のアルカロイドその4 dl -Phellodendrineならびにその異性体の合成

J. Kunitomo, M. Tomita, 1960 .

Studies on the Alkaloids of Rutaceous Plants. V: Alkaloids of Phellodendron amurense RUPR. var. sachalinense FR. SCHM@@@ヒロハキハダ Phellodendron amurense RUPR. var. sachalinense FR. SCHM.のアルカロイドその1

J. Kunitomo, M. Tomita, 1958 .

[Isolation of new base, dehydronantenine and lignan, (-)-episyringaresinol from Nandina domestica Thunb (author's transl)].

J. Kunitomo, M. Ju-ichi, Y. Yoshikawa, 1975, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

[On the analysis of the alkaloids of Nandina domestica Thunb. using gas chromatography-mass spectrometry (GC-MS) (author's transl)].

J. Kunitomo, M. Ju-ichi, Y. Masada, 1974, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

[Studies on the alkaloids of berberidaceous plants. XXXIV. Alkaloids of Nandina domestica Thunb. (8)].

J. Kunitomo, K. Morimoto, S. Tanaka, 1972, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

A novel oxazine ring closure reaction affording (Z)-((E)-2-styrylbenzo[b]furo[3,2-d][1,3]oxazin-4-ylideno)acetaldehydes and their anti-osteoclastic bone resorption activity.

J. Kunitomo, R. Fukuyama, H. Nakamuta, 2006, Bioorganic & medicinal chemistry letters.

Alkaloids of Nelumbo nucifera

J. Kunitomo, S. Tanaka, K. Isoi, 1973 .

Imenine, a ring-B substituted aporphine alkaloid

J. Kunitomo, M. Cava, R. Cook, 1969 .

[Studies on the alkaloids of Nelumbo nucifera Gaertn. XIV. On the tertiary base].

J. Kunitomo, H. Furukawa, Y. Okamoto, 1970, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

The alkaloids of Stephania sasakii: Structure of five new alkaloids☆

J. Kunitomo, I. Chen, T. Shingu, 1980 .

Studies on the Alkaloids of Menispermaceous Plants. CLXXXIII: Alkaloids of Cocculus laurifolius DC. (Suppl. 18). Structure of Coclanoline. (3)@@@コウシウウヤク Cocculus laurifolius DC. のアルカロイド (補遺18) Coclanolineの構造その3

J. Kunitomo, 1961 .

[STUDIES ON THE ALKALOIDS OF NELUMBO NUCIFERA GAERTN. VI. ALKALOIDS OF "GEN-SHI-HASU"].

J. Kunitomo, C. Yamamoto, T. Otsuki, 1964, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

O-Methyldeoxopunjabine, a Secobisbenzylisoquinoline Alkaloid Bearing an Aryl Methyl Group, and Three Other Secobisbenzylisoquinoline Alkaloids, O-Methylpunjabine, Secocepharanthine, and Dihydrosecocepharanthine, from Stephania Sasakii

J. Kunitomo, Makoto Suzuki, K. Harada, 1985 .

ASYMMETRIC SYNTHESIS OF (R)-(+)-NORANICANINE

J. Kunitomo, K. Takaba, K. Komori, 1996 .