Ping Chen

发表

Imidazoquinoxaline Src-family kinase p56Lck inhibitors: SAR, QSAR, and the discovery of (S)-N-(2-chloro-6-methylphenyl)-2-(3-methyl-1-piperazinyl)imidazo- [1,5-a]pyrido[3,2-e]pyrazin-6-amine (BMS-279700) as a potent and orally active inhibitor with excellent in vivo antiinflammatory activity.

Ping Chen, A. Doweyko, Derek J. Norris, 2004, Journal of medicinal chemistry.

Biphenylsulfonamide endothelin receptor antagonists. 4. Discovery of N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), a highly potent and orally active ET(A) selective antagonist.

Ping Chen, S. Spergel, S. Chong, 2003, Journal of medicinal chemistry.

Overriding Imatinib Resistance with a Novel ABL Kinase Inhibitor

Ping Chen, Derek J. Norris, C. Sawyers, 2004, Science.

2-aminothiazole as a novel kinase inhibitor template. Structure-activity relationship studies toward the discovery of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (dasatinib, BMS-354825) as a potent pan-Src kinase in

Ping Chen, A. Doweyko, Derek J. Norris, 2006, Journal of medicinal chemistry.

Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays.

Ping Chen, A. Doweyko, Derek J. Norris, 2004, Journal of medicinal chemistry.

Fluoropyrrolidine amides as dipeptidyl peptidase IV inhibitors.

Ping Chen, N. Thornberry, B. Leiting, 2004, Bioorganic & medicinal chemistry letters.

Bicyclic [3.3.0]-Octahydrocyclopenta[c]pyrrolo Antagonists of Retinol Binding Protein 4: Potential Treatment of Atrophic Age-Related Macular Degeneration and Stargardt Disease.

Ping Chen, D. Kitchen, C. Cywin, 2015, Journal of medicinal chemistry.

Design, Synthesis, and Evaluation of Nonretinoid Retinol Binding Protein 4 Antagonists for the Potential Treatment of Atrophic Age-Related Macular Degeneration and Stargardt Disease

Ping Chen, D. Kitchen, C. Cywin, 2014, Journal of medicinal chemistry.

Design, synthesis and evaluation of novel bis-substituted aromatic amide dithiocarbamate derivatives as colchicine site tubulin polymerization inhibitors with potent anticancer activities.

Ping Chen, Sai-Yang Zhang, Jian Song, 2021, European journal of medicinal chemistry.

Design, Synthesis, and Preclinical Efficacy of Novel Nonretinoid Antagonists of Retinol-Binding Protein 4 in the Mouse Model of Hepatic Steatosis.

Ping Chen, D. Kitchen, W. Blaner, 2019, Journal of medicinal chemistry.

Novel tetrahydropyran analogs as dipeptidyl peptidase IV inhibitors: Profile of clinical candidate (2R,3S,5R)-2- (2,5-difluorophenyl)-5-(4,6-dihydropyrrolo [3,4-c]pyrazol-5-(1H)-yl)tetrahydro-2H-pyran-3-amine (23) [corrected].

Ping Chen, G. Scapin, R. S. Roy, 2013, Bioorganic & medicinal chemistry letters.

Structure-activity-relationship of amide and sulfonamide analogs of omarigliptin.

Youwei Yan, Ping Chen, J. Metzger, 2015, Bioorganic & medicinal chemistry letters.

Novel inhibitors of IMPDH: a highly potent and selective quinolone-based series.

D. Cheney, Ping Chen, Derek J. Norris, 2003, Bioorganic & medicinal chemistry letters.

Fluoropyrrolidine amides as dipeptidyl peptidase IV inhibitors.

Ping Chen, N. Thornberry, B. Leiting, 2004, Bioorganic & medicinal chemistry letters.

Inhibitors of inosine monophosphate dehydrogenase: SARs about the N-[3-Methoxy-4-(5-oxazolyl)phenyl moiety.

D. Cheney, Ping Chen, Henry H. Gu, 2003, Bioorganic & medicinal chemistry letters.

Syntheses and biological evaluation of 5-(piperidin-1-yl)-3-phenyl-pentylsulfones as CCR5 antagonists.

D. Hazuda, Ping Chen, W. Schleif, 2004, Bioorganic & medicinal chemistry letters.

1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists: modifications of the arylpropylpiperidine side chains.

D. Hazuda, Ping Chen, W. Schleif, 2003, Bioorganic & medicinal chemistry letters.

C-3 Amido-indole cannabinoid receptor modulators.

Ping Chen, Derek J. Norris, K. McIntyre, 2002, Bioorganic & medicinal chemistry letters.

Discovery and initial SAR of 2-amino-5-carboxamidothiazoles as inhibitors of the Src-family kinase p56(Lck).

Ping Chen, A. Doweyko, R. Moquin, 2003, Bioorganic & medicinal chemistry letters.

Synthesis and SAR of novel imidazoquinoxaline-based Lck inhibitors: improvement of cell potency.

Ping Chen, Derek J. Norris, Henry H. Gu, 2002, Bioorganic & medicinal chemistry letters.

Imidazopiperidine amides as dipeptidyl peptidase IV inhibitors for the treatment of diabetes.

Ping Chen, N. Thornberry, B. Leiting, 2007, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of [(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]cyclohexanes and 4-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]piperidines as DPP-4 inhibitors.

Ping Chen, N. Thornberry, Huaibing He, 2011, Bioorganic & medicinal chemistry letters.

Novel pyrrolo[2,1-f][1,2,4]triazin-4-amines: Dual inhibitors of EGFR and HER2 protein tyrosine kinases.

Ping Chen, Derek J. Norris, J. Tokarski, 2011, Bioorganic & medicinal chemistry letters.

Active Constituents in Danshen and Their Pharmacological Actions

Ping Chen, G. Du, Yitao Wang, 2015 .

The discovery of N-((2H-tetrazol-5-yl)methyl)-4-((R)-1-((5r,8R)-8-(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl)-4,4-dimethylpentyl)benzamide (SCH 900822): a potent and selective glucagon receptor antagonist.

Ping Chen, W. Greenlee, A. Stamford, 2014, Journal of medicinal chemistry.

Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419).

Ping Chen, Henry H. Gu, E. Iwanowicz, 2007, Journal of medicinal chemistry.

Identification of novel and potent isoquinoline aminooxazole-based IMPDH inhibitors.

D. Cheney, Ping Chen, Derek J. Norris, 2003, Bioorganic & medicinal chemistry letters.

Identification of new diamine scaffolds with activity against Mycobacterium tuberculosis.

Ping Chen, C. Nacy, B. Nikonenko, 2006, Journal of medicinal chemistry.

New C-5 substituted pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases.

Henry Wong, Punit Marathe, John S Tokarski, 2007, Bioorganic & medicinal chemistry letters.

Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases.

Kenny K. Wong, Ping Chen, M. Maccoss, 2004, Bioorganic & medicinal chemistry letters.

Structure-Based Design of (5-Arylamino-2H-pyrazol-3-yl)-biphenyl-2‘,4‘-diols as Novel and Potent Human CHK1 Inhibitors

Enhong Chen, Ping Chen, Karen Lundgren, 2007 .

Sesquiterpenoids from the Fruits of Alpinia oxyphylla and Their Anti-Acetylcholinesterase Activity

Ping Chen, Pei-Pei Wang, Lan Xiang, 2014 .

Two Halogenated Sesquiterpenoids from the Fruits of Alpinia oxyphylla

Ping Chen, L. Tian, Pei-Pei Wang, 2013 .

Rational design and synthesis of an orally active indolopyridone as a novel conformationally constrained cannabinoid ligand possessing antiinflammatory properties.

Ping Chen, Derek J. Norris, S. Spergel, 2003, Journal of medicinal chemistry.

A new facile method for the synthesis of 1-arylimidazole-5-carboxylates

Ping Chen, J. Barrish, Zhongqi Shen, 2000 .

Discovery and initial SAR of imidazoquinoxalines as inhibitors of the Src-family kinase p56(Lck).

J. Y. Roberge, Ping Chen, A. Doweyko, 2002, Bioorganic & medicinal chemistry letters.

Further Daphniphyllum Alkaloids from the Bark of Daphniphyllum macropodum Miq.

Ping Chen, Zhen-Yu Li, Yue‐Wei Guo, 2008 .

A practical method for the preparation of α′-chloroketones of N-carbamate protected-α-aminoacids

Ping Chen, S. Spergel, J. Barrish, 1997 .

Synthesis and determination of absolute configuration of tetracetate 4a-carba-D-xylofuranoside

Ping Chen, Y. Li, Z. Xue, 2006 .

Reaction of quinoxalin-2-ones with TosMIC reagent: synthesis of imidazo[1,5-a]quinoxalin-4-ones

Ping Chen, James Lin, E. Iwanowicz, 2001 .

Synthesis of imidazo[1,5-a]quinoxalin-4(5H)-one template via a novel intramolecular cyclization process

Ping Chen, Derek J. Norris, R. Moquin, 2001 .

Flavonol galactoside caffeiate ester and homoisoflavones from Caesalpinia millettii HOOK. et ARN.

Ping Chen, Jun-shan Yang, 2007, Chemical & pharmaceutical bulletin.

Synergistic interactions of SQ109, a new ethylene diamine, with front-line antitubercular drugs in vitro.

Ping Chen, Ping Chen, C. Nacy, 2006, The Journal of antimicrobial chemotherapy.

Identification of a new antitubercular drug candidate, SQ109, from a combinatorial library of 1,2-ethylenediamines.

Ping Chen, C. Nacy, B. Nikonenko, 2005, The Journal of antimicrobial chemotherapy.

Two New Saccharide Fatty Acid Esters from the Fruit of Morinda citrifolia L . and Their ABTS Radical Scavenging Activities

Ping Chen, Shu-min Liu, Yu Wang, 2013 .

Biscembranoids and their probable biogenetic precursor from the Hainan soft coral Sarcophyton tortuosum.

Ping Chen, M. Gavagnin, E. Mollo, 2007, Journal of natural products.

Iridoid glycosyl esters from Scrophularia ningpoensis

Ping Chen, Yun-Hai Liu, Xin Chen, 2007, Natural product research.

Structure-activity-relationship studies of conformationally restricted analogs of combretastatin A-4 derived from SU5416.

Ping Chen, Dan L Sackett, Pui-Kai Li, 2006, Bioorganic & medicinal chemistry.

Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes.

Kathy Lyons, Ping Chen, Dennis Feng, 2014, Journal of medicinal chemistry.

Structure-Based Drug Design and Synthesis of PI3Kα-Selective Inhibitor (PF-06843195).

Ping Chen, Hong Shen, M. Pairish, 2020, Journal of medicinal chemistry.

α-hydroxyamide derived aminodiols as potent inhibitors of hiv protease

Ping Chen, S. Spergel, J. Barrish, 1995 .

Discovery of novel 2-(aminoheteroaryl)-thiazole-5-carboxamides as potent and orally active Src-family kinase p56(Lck) inhibitors.

Ping Chen, A. Doweyko, Derek J. Norris, 2004, Bioorganic & medicinal chemistry letters.

Macropodumines D and E, two new alkaloids with unusual skeletons from Daphniphyllum macropodum Miq.

Ping Chen, Zhen-Yu Li, Yue‐Wei Guo, 2007, Organic Letters.

Further Daphniphyllum Alkaloids from the Leaves of Daphniphyllum macropodum Miq.

Ping Chen, Zhen-Yu Li, Yue‐Wei Guo, 2007 .

Identification of 2-amino-5-(thioaryl)thiazoles as inhibitors of nerve growth factor receptor TrkA.

Ping Chen, R. Moquin, J. Tokarski, 2008, Bioorganic & medicinal chemistry letters.

Discovery of Novel 2-(Aminoheteroaryl)-thiazole-5-carboxamides as Potent and Orally Active Src-Family Kinase p56Lck Inhibitors.

Ping Chen, 2005 .

Discovery of non-zwitterionic aryl sulfonamides as Nav1.7 inhibitors with efficacy in preclinical behavioral models and translational measures of nociceptive neuron activation.

Andrea Mcclure, Ping Chen, N. Meanwell, 2017, Bioorganic & medicinal chemistry.

Azepino-indazoles as calcitonin gene-related peptide (CGRP) receptor antagonists.

Kimberly A. Widmann, Ping Chen, J. Macor, 2020, Bioorganic & medicinal chemistry letters.

3-cyanoindole-based inhibitors of inosine monophosphate dehydrogenase: synthesis and initial structure-activity relationships.

Ping Chen, Derek J. Norris, Henry H. Gu, 2003, Bioorganic & medicinal chemistry letters.

Discovery of (S,E)-3-(2-fluorophenyl)-N-(1-(3-(pyridin-3-yloxy)phenyl)ethyl)-acrylamide as a potent and efficacious KCNQ2 (Kv7.2) opener for the treatment of neuropathic pain.

V. Gribkoff, Ping Chen, S. Dworetzky, 2013, Bioorganic & medicinal chemistry letters.

Discovery of dipiperidines as new antitubercular agents.

Ping Chen, C. Nacy, E. Bogatcheva, 2010, Bioorganic & medicinal chemistry letters.

Identification of SQ609 as a lead compound from a library of dipiperidines.

Ping Chen, C. Nacy, B. Nikonenko, 2011, Bioorganic & medicinal chemistry letters.

5-((4-Aminopiperidin-1-yl)methyl)pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases.

Henry Wong, Punit Marathe, John S Tokarski, 2007, Bioorganic & medicinal chemistry letters.

Development of spiroguanidine-derived α7 neuronal nicotinic receptor partial agonists.

Ping Chen, J. Macor, Yulia Benitex, 2017, Bioorganic & medicinal chemistry letters.

Calcitonin Gene-Related Peptide (CGRP) Receptor Antagonists: Heterocyclic Modification of a Novel Azepinone Lead.

Kimberly A. Widmann, Ping Chen, J. Macor, 2021, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of [(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]cyclohexanes and 4-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]piperidines as DPP-4 inhibitors.

Ping Chen, N. Thornberry, Huaibing He, 2011, Bioorganic & medicinal chemistry letters.