Henry H. Gu

发表

Imidazoquinoxaline Src-family kinase p56Lck inhibitors: SAR, QSAR, and the discovery of (S)-N-(2-chloro-6-methylphenyl)-2-(3-methyl-1-piperazinyl)imidazo- [1,5-a]pyrido[3,2-e]pyrazin-6-amine (BMS-279700) as a potent and orally active inhibitor with excellent in vivo antiinflammatory activity.

Ping Chen, A. Doweyko, Derek J. Norris, 2004, Journal of medicinal chemistry.

Novel inhibitors of IMPDH: a highly potent and selective quinolone-based series.

D. Cheney, Ping Chen, Derek J. Norris, 2003, Bioorganic & medicinal chemistry letters.

Inhibitors of inosine monophosphate dehydrogenase: SARs about the N-[3-Methoxy-4-(5-oxazolyl)phenyl moiety.

D. Cheney, Ping Chen, Henry H. Gu, 2003, Bioorganic & medicinal chemistry letters.

Synthesis and SAR of novel imidazoquinoxaline-based Lck inhibitors: improvement of cell potency.

Ping Chen, Derek J. Norris, Henry H. Gu, 2002, Bioorganic & medicinal chemistry letters.

Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419).

Ping Chen, Henry H. Gu, E. Iwanowicz, 2007, Journal of medicinal chemistry.

Novel guanidine-based inhibitors of inosine monophosphate dehydrogenase.

Henry H. Gu, E. Iwanowicz, J. Barrish, 2002, Bioorganic & medicinal chemistry letters.

Novel amide-based inhibitors of inosine 5'-monophosphate dehydrogenase.

Henry H. Gu, E. Iwanowicz, J. Barrish, 2002, Bioorganic & medicinal chemistry letters.

Novel diamide-based inhibitors of IMPDH.

Henry H. Gu, E. Iwanowicz, M. Witmer, 2002, Bioorganic & medicinal chemistry letters.

A modified approach to 2-(N-aryl)-1,3-oxazoles: application to the synthesis of the IMPDH inhibitor BMS-337197 and analogues.

Henry H. Gu, E. Iwanowicz, W. Pitts, 2002, Organic letters.

Reaction of tetracarbonyl(π-allyl)manganese with carbon nucleophiles☆

Henry H. Gu, K. McDaniel, W. S. Vaughan, 1997 .

Discovery and initial SAR of imidazoquinoxalines as inhibitors of the Src-family kinase p56(Lck).

J. Y. Roberge, Ping Chen, A. Doweyko, 2002, Bioorganic & medicinal chemistry letters.

Intramolecular cyclopropanation of 7-diazotethered-1,3,5-cycloheptatriene: Preparation and reactions of tricyclo[5.3.0.02,10]deca-3,5-dien-9-one

Henry H. Gu, A. Rheingold, G. Yap, 1997 .

The Enantioselective Synthesis of anti-β-Hydroxy-α-Amino Acids via the Reaction of Lithium Enolates of Glycine Bearing an Oxazolidine Chiral Auxiliary with Aldehydes

Henry H. Gu, E. Iwanowicz, P. Cheng, 1998 .

Rapid synthesis of triazine inhibitors of inosine monophosphate dehydrogenase.

D. Cheney, Henry H. Gu, E. Iwanowicz, 2002, Bioorganic & medicinal chemistry letters.

3-cyanoindole-based inhibitors of inosine monophosphate dehydrogenase: synthesis and initial structure-activity relationships.

Ping Chen, Derek J. Norris, Henry H. Gu, 2003, Bioorganic & medicinal chemistry letters.

A survey of cyclic replacements for the central diamide moiety of inhibitors of inosine monophosphate dehydrogenase.

Henry H. Gu, E. Iwanowicz, J. Barrish, 2002, Bioorganic & medicinal chemistry letters.

Discovery of N-[2-[2-[[3-methoxy-4-(5-oxazolyl)phenyl]amino]-5-oxazolyl]phenyl]-N-methyl-4- morpholineacetamide as a novel and potent inhibitor of inosine monophosphate dehydrogenase with excellent in vivo activity.

D. Cheney, Henry H. Gu, E. Iwanowicz, 2002, Journal of medicinal chemistry.