S. Kanner

发表

Imidazoquinoxaline Src-family kinase p56Lck inhibitors: SAR, QSAR, and the discovery of (S)-N-(2-chloro-6-methylphenyl)-2-(3-methyl-1-piperazinyl)imidazo- [1,5-a]pyrido[3,2-e]pyrazin-6-amine (BMS-279700) as a potent and orally active inhibitor with excellent in vivo antiinflammatory activity.

Ping Chen, A. Doweyko, Derek J. Norris, 2004, Journal of medicinal chemistry.

An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance

Michael Peyton, John D. Minna, Li Shen, 2012, Clinical Cancer Research.

Transformation-specific tyrosine phosphorylation of a novel cellular protein in chicken cells expressing oncogenic variants of the avian cellular src gene

J. Parsons, S. Kanner, A. Reynolds, 1989, Molecular and cellular biology.

Discovery of 4-phenyl-2-phenylaminopyridine based TNIK inhibitors.

K. Parnell, S. Kanner, Yong Xu, 2013, Bioorganic & medicinal chemistry letters.

Developmental regulation of pp44/46, tyrosine-phosphorylated proteins associated with tyrosine/serine kinase activity in Trypanosoma brucei.

S. Kanner, G. Schieven, M. Parsons, 1994, Molecular and biochemical parasitology.

Transformation by pp60src or stimulation of cells with epidermal growth factor induces the stable association of tyrosine-phosphorylated cellular proteins with GTPase-activating protein

J. Parsons, S. Kanner, J. Gibbs, 1991, Molecular and cellular biology.

Nuclear localization of the tyrosine kinase Itk and interaction of its SH3 domain with karyopherin α (Rch1α)

S. Kanner, S. Nadler, J. Pérez-Villar, 2001 .

CD5 Negatively Regulates the T-Cell Antigen Receptor Signal Transduction Pathway: Involvement of SH2-Containing Phosphotyrosine Phosphatase SHP-1

S. Kanner, A. Aruffo, M. Bowen, 1999, Molecular and Cellular Biology.

CD4, CD8 and the role of CD45 in T-cell activation.

S. Kanner, G. Schieven, A. Aruffo, 1993, Current opinion in immunology.

Wiskott-Aldrich syndrome/X-linked thrombocytopenia: WASP gene mutations, protein expression, and phenotype.

S. Kanner, H. Ochs, A. Aruffo, 1997, Blood.

A Small-Molecule Inhibitor of PIM Kinases as a Potential Treatment for Urothelial Carcinomas

S. Kanner, Yong Xu, S. Tripp, 2014, Neoplasia.

A role for CD5 in TCR-mediated signal transduction and thymocyte selection.

K. Rajewsky, A. Tarakhovsky, S. Kanner, 1995, Science.

Tyrosine phosphorylation of a 120-kilodalton pp60src substrate upon epidermal growth factor and platelet-derived growth factor receptor stimulation and in polyomavirus middle-T-antigen-transformed cells

J. Parsons, S. Kanner, A. B. Reynolds, 1991 .

Activation of murine T-cells via phospholipase-C gamma 1-associated protein tyrosine phosphorylation is reduced with aging.

P. Rabinovitch, S. Kanner, T. Kavanagh, 1995, The journals of gerontology. Series A, Biological sciences and medical sciences.

Focal adhesion kinase regulates beta1 integrin-dependent T cell migration through an HEF1 effector pathway.

S. Kanner, G. O'Neill, E. Golemis, 2001, European journal of immunology.

Focal adhesion kinase regulates β1 integrin‐dependent T cell migration through an HEF1 effector pathway

S. Kanner, G. O'Neill, E. Golemis, 2001, European journal of immunology.

CD 22-mediated stimulation of T cells regulates T-cell receptor / CD 3-induced signaling ( CD 22 / CD 45 / sialic acid / carbohydrate / adheslon )

S. Kanner, A. Aruffo, J. Ledbetter, 2022 .

CD22-mediated stimulation of T cells regulates T-cell receptor/CD3-induced signaling.

D. Sgroi, I. Stamenkovic, S. Kanner, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Monoclonal antibodies to six-transmembrane epithelial antigen of the prostate-1 inhibit intercellular communication in vitro and growth of human tumor xenografts in vivo.

S. Kanner, A. Raitano, Z. An, 2007, Cancer research.

Mutational activation of pp60(c-src) leads to a tumorigenic phenotype in a preneoplastic Syrian hamster embryo cell line.

S. Kanner, T. Gilmer, T. J. Lansing, 1997, Cancer research.

A 42-kD tyrosine kinase substrate linked to chromaffin cell secretion exhibits an associated MAP kinase activity and is highly related to a 42-kD mitogen-stimulated protein in fibroblasts

S. Kanner, T. Sturgill, J. Litz, 1990, The Journal of cell biology.

Stable association of activated pp60src with two tyrosine-phosphorylated cellular proteins

J. Parsons, S. Kanner, A. Reynolds, 1989, Molecular and cellular biology.

Immunoaffinity purification of tyrosine-phosphorylated cellular proteins.

J. Parsons, S. Kanner, A. Reynolds, 1989, Journal of immunological methods.

Integrin signalling defects in T-lymphocytes in systemic lupus erythematosus

S. Kanner, D. D'cruz, R. Wickremasinghe, 1999, Lupus.

Regulated association between the tyrosine kinase Emt/Itk/Tsk and phospholipase-C gamma 1 in human T lymphocytes.

S. Kanner, J. Pérez-Villar, J. Perez-Villar, 1999, Journal of immunology.

in Human T Lymphocytes g Kinase Emt/Itk/Tsk and Phospholipase-C Regulated Association Between the Tyrosine

S. Kanner, J. Pérez-Villar, 1999 .

Development of an RNAi therapeutic for alpha-1-antitrypsin liver disease.

S. Kanner, D. Lewis, V. Subbotin, 2020, JCI insight.

The SH2 and SH3 domains of pp60src direct stable association with tyrosine phosphorylated proteins p130 and p110.

J. Parsons, S. Kanner, R. Vines, 1991, The EMBO journal.

Selective Itk inhibitors block T-cell activation and murine lung inflammation.

A. Doweyko, S. Spergel, R. Moquin, 2004, Biochemistry.

A Major Tyrosine-phosphorylated Protein of Trypanosoma brucei Is a Nucleolar RNA-binding Protein*

S. Kanner, M. Parsons, A. Das, 1996, The Journal of Biological Chemistry.

Beta 2-integrin LFA-1 signaling through phospholipase C-gamma 1 activation.

S. Kanner, J. Ledbetter, N. Damle, 1993, Proceedings of the National Academy of Sciences of the United States of America.

A transmembrane-anchored chimeric focal adhesion kinase is constitutively activated and phosphorylated at tyrosine residues identical to pp125FAK.

S. Kanner, A. Aruffo, P. Chan, 1994, The Journal of biological chemistry.

Novel tyrosine phosphorylations accompany the activation of pp60c-src during chemical carcinogenesis.

J. Parsons, S. Kanner, T. Gilmer, 1989, Oncogene.

Lymphocyte lineage-restricted tyrosine-phosphorylated proteins that bind PLC gamma 1 SH2 domains.

S. Kanner, G. Schieven, A. Aruffo, 1992, The Journal of biological chemistry.

Discovery and SAR of 2-amino-5-[(thiomethyl)aryl]thiazoles as potent and selective Itk inhibitors.

A. Doweyko, S. Spergel, R. Moquin, 2006, Bioorganic & medicinal chemistry letters.

ZAP-70 tyrosine kinase, CD45, and T cell receptor involvement in UV- and H2O2-induced T cell signal transduction.

S. Kanner, G. Schieven, J. Ledbetter, 1994, The Journal of biological chemistry.

Ligation of the T-cell Antigen Receptor (TCR) Induces Association of hSos1, ZAP-70, Phospolipase C-γ1, and Other Phosphoproteins with Grb2 and the ζ-Chain of the TCR (*)

S. Kanner, A. Nel, Shalini Gupta, 1995, The Journal of Biological Chemistry.

Simultaneous infections with human T cell leukemia virus type I and the human immunodeficiency virus.

S. Kanner, W. Parks, E. Parks, 1987, The Journal of infectious diseases.

Identification and Characterization of a Novel Cytoskeleton-Associated pp6Osrc Substrate

J. Parsons, S. Kanner, A. Reynolds, 2022 .

J. Parsons, S. Kanner, A. Reynolds, 1991, Molecular and cellular biology.

ZAP-70 and p72syk are signaling response elements through MHC class II molecules.

S. Kanner, G. Schieven, J. Ledbetter, 1995, Tissue antigens.

Evidence for LFA‐1/ICAM‐1 dependent stimulation of protein tyrosine phosphorylation in human B lymphoid cell lines during homotypic adhesion

S. Kanner, A. Nel, S. Gupta, 1995, Journal of leukocyte biology.

Coengagement of CD2 with LFA‐1 or VLA‐4 by bispecific ligand fusion proteins primes T cells to respond more effectively to T cell receptor‐dependent signals

P. Linsley, S. Kanner, A. Aruffo, 1994, Journal of leukocyte biology.

Discovery and initial SAR of 2-amino-5-carboxamidothiazoles as inhibitors of the Src-family kinase p56(Lck).

Ping Chen, A. Doweyko, R. Moquin, 2003, Bioorganic & medicinal chemistry letters.

CD2/LFA-3 ligation induces phospholipase-C gamma 1 tyrosine phosphorylation and regulates CD3 signaling.

S. Kanner, A. Aruffo, J. Ledbetter, 1992, Journal of immunology.

Altering T-cell activation by targeting the multidomain tyrosine kinase Itk.

S. Kanner, J. Pérez-Villar, J. Perez-Villar, 2003, Trends in immunology.

Tyrosine phosphorylation of three cellular proteins correlates with transformation of rat 1 cells by pp60src

J. Parsons, S. Kanner, A. Bouton, 1991, Molecular carcinogenesis.

Interaction of CD4:lck with the T cell receptor/CD3 complex induces early signaling events in the absence of CD45 tyrosine phosphatase

S. Kanner, R. Torres, J. Ledbetter, 1992, European journal of immunology.

Tyrosine phosphorylation of CD19 in pre‐B and mature B cells.

S. Kanner, G. Schieven, A. Aruffo, 1993, The EMBO journal.

Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav.

S. Kanner, G. Schieven, R. Dunn, 2002, Biochemistry.

Interleukin-2 induces beta2-integrin-dependent signal transduction involving the focal adhesion kinase-related protein B (fakB).

S. Kanner, C. Geisler, A. Svejgaard, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Ligation of the T-cell antigen receptor (TCR) induces association of hSos1, ZAP-70, phospholipase C-gamma 1, and other phosphoproteins with Grb2 and the zeta-chain of the TCR.

S. Kanner, A. Nel, S. Gupta, 1995, The Journal of biological chemistry.

Sulfhydryl oxidation down-regulates T-cell signaling and inhibits tyrosine phosphorylation of phospholipase C gamma 1.

P. Rabinovitch, S. Kanner, T. Kavanagh, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Lymphocyte antigen receptor activation of a focal adhesion kinase-related tyrosine kinase substrate.

S. Kanner, A. Aruffo, P. Chan, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Nuclear localization of the tyrosine kinase Itk and interaction of its SH3 domain with karyopherin alpha (Rch1alpha).

S. Kanner, S. Nadler, J. Pérez-Villar, 2001, International immunology.

Synthesis and Biological Evaluation of Pyrazolo[1,5-a]pyrimidine Compounds as Potent and Selective Pim-1 Inhibitors.

S. Kanner, Yong Xu, Koc-Kan Ho, 2015, ACS medicinal chemistry letters.

Discovery of 3-(trifluoromethyl)-1H-pyrazole-5-carboxamide activators of the M2 isoform of pyruvate kinase (PKM2).

K. Parnell, S. Kanner, Yong Xu, 2014, Bioorganic & medicinal chemistry letters.

Design, synthesis, and anti-inflammatory properties of orally active 4-(phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38alpha mitogen-activated protein kinase inhibitors.

John Dodd, John S Tokarski, Arthur M Doweyko, 2008, Journal of medicinal chemistry.

Identification and characterization of a novel cytoskeleton-associated pp60src substrate

J. Parsons, S. Kanner, A. Reynolds, 1991, Molecular and cellular biology.

RNAi-based treatment of chronically infected patients and chimpanzees reveals that integrated hepatitis B virus DNA is a source of HBsAg

S. Kanner, M. Yuen, D. Lewis, 2017, Science Translational Medicine.

Epigenetic Drug Discovery

K. Parnell, S. Kanner, T. Hendrickson, 2012, Journal of biomolecular screening.

Phosphorylation-specific status of RNAi triggers in pharmacokinetic and biodistribution analyses

Darren H. Wakefield, S. Kanner, D. Lewis, 2016, Nucleic acids research.

Harnessing type I CRISPR–Cas systems for genome engineering in human cells

Leslie S. Edwards, Stan J. J. Brouns, David B. Nyer, 2019, Nature Biotechnology.

Pharmacologic Activation of PKM2 Slows Lung Tumor Xenograft Growth

K. Parnell, S. Kanner, Yong Xu, 2013, Molecular Cancer Therapeutics.

Small Molecule Therapeutics Pharmacologic Activation of PKM 2 Slows Lung Tumor Xenograft Growth

K. Parnell, S. Kanner, Yong Xu, 2013 .

CD28 cross-linking augments TCR-mediated signals and costimulates superantigen responses.

P. Linsley, S. Kanner, J. Ledbetter, 1995, Journal of immunology.

Human T and B lymphocytes express a structurally conserved focal adhesion kinase, pp125FAK.

S. Kanner, A. Aruffo, J. Blake, 1993, DNA and cell biology.

Therapeutic Target for Overcoming EGFR Inhibitor Resistance Resistance to EGFR and PI 3 K Inhibitors and Identifies Axl as a Mesenchymal Transition Gene Signature Predicts

Edward S. Kim, J. Weinstein, K. Coombes, 2012 .

Targeting Factor 12 (F12) with a Novel RNAi Delivery Platform As a Prophylactic Treatment for Hereditary Angioedema (HAE)

Darren H. Wakefield, S. Melquist, D. Lewis, 2016 .

Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases.

J. Parsons, S. Kanner, A. Reynolds, 1990, Proceedings of the National Academy of Sciences of the United States of America.

The human p167 gene encodes a unique structural protein that contains centrosomin A homology and associates with a multicomponent complex.

S. Kanner, J. Scholler, 1997, DNA and cell biology.

CD3-zeta surface expression is required for CD4-p56lck-mediated upregulation of T cell antigen receptor-CD3 signaling in T cells.

S. Kanner, J. Ledbetter, C. Terhorst, 1992, The Journal of biological chemistry.

SRChing for the substrates of Src

S. Weed, J. Parsons, S. Kanner, 2014, Oncogene.

Mitogenic properties of a bispecific single-chain Fv-Ig fusion generated from CD2-specific mAb to distinct epitopes.

S. Kanner, J. Ledbetter, R. Connelly, 1998, International immunology.

Regulation of CD3-induced phospholipase C-gamma 1 (PLC gamma 1) tyrosine phosphorylation by CD4 and CD45 receptors.

S. Kanner, J. Ledbetter, J. Deans, 1992, Immunology.

CD45 modulates T cell receptor/CD3‐induced activation of human thymocytes via regulation of tyrosine phosphorylation

S. Kanner, G. Schieven, C. Thompson, 1992, European journal of immunology.

HIV-1 down-regulates CD4 costimulation of TCR/CD3-directed tyrosine phosphorylation through CD4/p56lck dissociation.

S. Kanner, O. Haffar, 1995, Journal of immunology.

Filamin binds to the cytoplasmic domain of the beta1-integrin. Identification of amino acids responsible for this interaction.

S. Kanner, A. Aruffo, D. Loo, 1998, The Journal of biological chemistry.

Filamin Binds to the Cytoplasmic Domain of the β1-Integrin

S. Kanner, A. Aruffo, D. Loo, 1998, The Journal of Biological Chemistry.

The discovery of orally active triaminotriazine aniline amides as inhibitors of p38 MAP kinase.

Wei Li, Gulzar Ahmed, John Dodd, 2004, Journal of medicinal chemistry.

The integrin-triggered rescue of T lymphocyte apoptosis is blocked in HIV-1-infected individuals.

S. Kanner, R. Wickremasinghe, W. Morrow, 1997, Journal of immunology.

HIF2α-Targeted RNAi Therapeutic Inhibits Clear Cell Renal Cell Carcinoma

Darren H. Wakefield, S. Kanner, D. Lewis, 2017, Molecular Cancer Therapeutics.

HIF 2 a-Targeted RNAi Therapeutic Inhibits Clear Cell Renal Cell Carcinoma

Eld, S. Kanner, D. Lewis, 2017 .

Title : HIF 2 α targeted RNAi therapeutic inhibits clear cell renal cell carcinoma

Darren H. Wakefield, S. Kanner, D. Lewis, 2017 .

Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors.

A. Doweyko, S. Spergel, R. Moquin, 2006, Bioorganic & medicinal chemistry letters.

Tumor Cell Metabolic Reprogramming and Drug Targeting

S. Kanner, 2014 .

Human retroviral env and gag polypeptides: serologic assays to measure infection.

C. Cheng‐Mayer, S. Kanner, L. Arthur, 1986, Journal of immunology.

Sulfhydryl oxidation down-regulates T-cell signaling and inhibits tyrosine phosphorylation of phospholipase Cyl

P. Rabinovitch, S. Kanner, J. Ledbetter, 2004 .

Use of AGS-16M8F as a novel antibody drug conjugate (ADC) for treating renal cancers.

S. Kanner, Z. An, M. Vincent, 2010 .

MHC class II molecules deliver costimulatory signals in human T cells through a functional linkage with IL-2-receptors.

S. Kanner, J. Ledbetter, N. Odum, 1993, Journal of immunology.

Treatment of Chronically HBV-Infected Chimpanzees with RNA Interference Therapeutic ARC-520 LED to Potent Reduction of Viral MRNA, DNA and Proteins without Observed Drug Resistance

S. Kanner, D. Lewis, R. Gish, 2016 .

Focal Adhesion Kinase-Related fakB Is Regulated by the Integrin LFA-1and Interacts with the SH3 Domain of Phospholipase Cγ1

S. Kanner, 1996 .

Allogeneic chimeric antigen receptor-T cells with CRISPR-disrupted programmed death-1 checkpoint exhibit enhanced functional fitness.

Leslie S. Edwards, S. Kanner, C. Fuller, 2023, Cytotherapy.

Superantigen and HLA-DR ligation induce phospholipase-C gamma 1 activation in class II+ T cells.

S. Kanner, J. Ledbetter, A. Svejgaard, 1992, Journal of Immunology.

Synthesis and structure-activity relationship of 2-arylamino-4-aryl-pyrimidines as potent PAK1 inhibitors.

K. Parnell, S. Kanner, Yong Xu, 2013, Bioorganic & medicinal chemistry letters.

A first-in-human phase 1, multicenter, open-label study of CB-011, a next-generation CRISPR-genome edited allogeneic anti-BCMA immune-cloaked CAR-T cell therapy, in patients with relapsed/refractory multiple myeloma (CAMMOUFLAGE trial).

S. Jagannath, D. Siegel, S. Kanner, 2023, Journal of Clinical Oncology.

Activation of pp60c-src tyrosine kinase specific activity in tumor-derived Syrian hamster embryo cells.

J. Parsons, S. Kanner, T. Gilmer, 1988, Oncogene.

Abstract 3762: Second generation PIM inhibitors exhibit improved activity in solid tumor models

S. Kanner, Yong Xu, Jihua Liu, 2012 .

Abstract C200: Second-generation PIM inhibitors exhibit improved activity in solid tumor models in vitro.

S. Kanner, Yong Xu, Jihua Liu, 2011 .