P. Agostinho

P. Agostinho, C. Oliveira, J. Melo, 2002, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

Convergence of adenosine and GABA signaling for synapse stabilization during development

O. Thoumine, Â. R. Tomé, P. Agostinho, 2021, Science.

Synthesis, biological evaluation, and molecular modeling of nitrile‐containing compounds: Exploring multiple activities as anti‐Alzheimer agents

P. Agostinho, Irene Bolea, R. Ramsay, 2020, Drug development research.

Intracellular free Na+ concentration increases in cultured retinal cells under oxidative stress conditions

P. Agostinho, C. Duarte, C. Oliveira, 1996, Neuroscience Research.

Alzheimer's disease-associated neurotoxic mechanisms and neuroprotective strategies.

P. Agostinho, P. Moreira, C. Pereira, 2005, Current drug targets. CNS and neurological disorders.

Synthesis, pharmacological assessment, and molecular modeling of acetylcholinesterase/butyrylcholinesterase inhibitors: effect against amyloid-β-induced neurotoxicity.

P. Agostinho, C. Pérez, Ignacio Moraleda, 2013, ACS chemical neuroscience.

Purinergic signaling orchestrating neuron-glia communication.

P. Agostinho, R. Cunha, P. Canas, 2020, Pharmacological research.

Caffeine Reverts Memory But Not Mood Impairment in a Depression-Prone Mouse Strain with Up-Regulated Adenosine A2A Receptor in Hippocampal Glutamate Synapses

A. Köfalvi, Catarina Gomes, M. Kaster, 2017, Molecular Neurobiology.

Adenosine modulation of d-[3H]aspartate release in cultured retina cells exposed to oxidative stress

P. Agostinho, R. Cunha, C. Oliveira, 2000, Neurochemistry International.

Crosstalk Between ATP-P2X7 and Adenosine A2A Receptors Controlling Neuroinflammation in Rats Subject to Repeated Restraint Stress

Â. R. Tomé, P. Agostinho, R. Cunha, 2021, Frontiers in Cellular Neuroscience.

Depression as a Glial-Based Synaptic Dysfunction

P. Agostinho, R. Cunha, R. Prediger, 2016, Front. Cell. Neurosci..

Spatial memory impairments in a prediabetic rat model

P. Agostinho, R. Cunha, R. Prediger, 2013, Neuroscience.

Blockade of adenosine A2A receptors prevents interleukin-1β-induced exacerbation of neuronal toxicity through a p38 mitogen-activated protein kinase pathway

Â. R. Tomé, P. Agostinho, R. Cunha, 2012, Journal of Neuroinflammation.

Adenosine A2A receptors regulate the extracellular accumulation of excitatory amino acids upon metabolic dysfunction in chick cultured retinal cells.

P. Agostinho, R. Cunha, A. Rego, 2000, Experimental eye research.

Localization and Trafficking of Amyloid-β Protein Precursor and Secretases: Impact on Alzheimer's Disease.

P. Agostinho, R. Cunha, C. Oliveira, 2015, Journal of Alzheimer's disease : JAD.

Cdk5: Multitasking between physiological and pathological conditions

P. Agostinho, J. P. Lopes, 2011, Progress in Neurobiology.

Susceptibility of hippocampal neurons to Aβ peptide toxicity is associated with perturbation of Ca2+ homeostasis

P. Agostinho, J. Malva, C. Oliveira, 2007, Brain Research.

Astrocytic A2A receptors: Novel targets to manage brain disorders: PS168.

P. Agostinho, R. Cunha, Vanessa Henriques, 2017, Porto biomedical journal.

Additional file 8: Figure S8. of Oncostatin M promotes excitotoxicity by inhibiting glutamate uptake in astrocytes: implications in HIV-associated neurotoxicity

David J. Volsky, Sabita Roy, P. Agostinho, 2016 .

Impairment of excitatory amino acid transporter activity by oxidative stress conditions in retinal cells: effect of antioxidants

P. Agostinho, C. Duarte, C. Oliveira, 1997, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Amyloid-beta peptide decreases glutamate uptake in cultured astrocytes: Involvement of oxidative stress and mitogen-activated protein kinase cascades

P. Agostinho, C. Oliveira, C. Oliveira, 2008, Neuroscience.

Adenosine A2A receptors modulate glutamate uptake in cultured astrocytes and gliosomes

P. Agostinho, R. Cunha, M. Schwarzschild, 2012, Glia.

Overactivation of calcineurin induced by amyloid-beta and prion proteins

P. Agostinho, C. Oliveira, J. P. Lopes, 2008, Neurochemistry International.

Activation of cell cycle proteins in transgenic mice in response to neuronal loss but not amyloid-beta and tau pathology.

P. Agostinho, F. LaFerla, M. Blurton-Jones, 2009, Journal of Alzheimer's disease : JAD.

Role of Cyclin-Dependent Kinase 5 in the Neurodegenerative Process Triggered by Amyloid-Beta and Prion Peptides: Implications for Alzheimer’s Disease and Prion-Related Encephalopathies

P. Agostinho, C. Oliveira, J. P. Lopes, 2007, Cellular and Molecular Neurobiology.

Comparative study of microglia activation induced by amyloid‐beta and prion peptides: Role in neurodegeneration

P. Agostinho, C. Oliveira, P. Garção, 2006, Journal of neuroscience research.

Caffeine and an adenosine A2A receptor antagonist prevent memory impairment and synaptotoxicity in adult rats triggered by a convulsive episode in early life

D. Souza, C. Müller, P. Agostinho, 2010, Journal of neurochemistry.

Adenosine Receptors in Alzheimer’s Disease

P. Agostinho, R. Cunha, P. Canas, 2018 .

Chronic caffeine consumption prevents memory disturbance in different animal models of memory decline.

P. Agostinho, R. Cunha, 2010, Journal of Alzheimer's disease : JAD.

Neuroinflammation and Mitochondrial Dysfunction in Alzheimer's and Prion's Diseases

P. Agostinho, C. Oliveira, 2007 .

Antagonistic Interaction between Adenosine A2A Receptors and Na+/K+-ATPase-α2 Controlling Glutamate Uptake in Astrocytes

P. Agostinho, R. Cunha, E. Augusto, 2013, The Journal of Neuroscience.

Presynaptic CB1 cannabinoid receptors control frontocortical serotonin and glutamate release – Species differences

Samira G. Ferreira, A. Köfalvi, K. Mackie, 2012, Neurochemistry International.

Prolonged nicotine exposure down-regulates presynaptic NMDA receptors in dopaminergic terminals of the rat nucleus accumbens

Â. R. Tomé, P. Agostinho, A. Pittaluga, 2014, Neuropharmacology.

Involvement of calcineurin in the neurotoxic effects induced by amyloid‐beta and prion peptides

P. Agostinho, C. Oliveira, 2003, The European journal of neuroscience.

P. Agostinho, R. Cunha, P. Canas, 2016, Journal of Alzheimer's disease : JAD.

Astrocytes and Adenosine A2A Receptors: Active Players in Alzheimer’s Disease

P. Agostinho, R. Cunha, Cátia R. Lopes, 2021, Frontiers in Neuroscience.

Association Between Adenosine A2A Receptors and Connexin 43 Regulates Hemichannels Activity and ATP Release in Astrocytes Exposed to Amyloid-β Peptides

P. Agostinho, R. Cunha, P. Canas, 2021, Molecular Neurobiology.

Functional interaction between pre‐synaptic α6β2‐containing nicotinic and adenosine A2A receptors in the control of dopamine release in the rat striatum

A. Köfalvi, Â. R. Tomé, P. Agostinho, 2013, British journal of pharmacology.

Neurodegenerative pathways in Parkinson's disease: therapeutic strategies.

P. Agostinho, P. Moreira, C. Pereira, 2005, Current drug targets. CNS and neurological disorders.

Deletion of Adenosine A2A Receptors From Astrocytes Disrupts Glutamate Homeostasis Leading to Psychomotor and Cognitive Impairment: Relevance to Schizophrenia

Y. T. Wang, P. Agostinho, R. Cunha, 2015, Biological Psychiatry.

Downregulation of Sirtuin 1 Does Not Account for the Impaired Long-Term Potentiation in the Prefrontal Cortex of Female APPswe/PS1dE9 Mice Modelling Alzheimer’s Disease

Samira G. Ferreira, Â. R. Tomé, P. Agostinho, 2023, International journal of molecular sciences.

Increased Synaptic ATP Release and CD73-Mediated Formation of Extracellular Adenosine in the Control of Behavioral and Electrophysiological Modifications Caused by Chronic Stress

Samira G. Ferreira, Â. R. Tomé, P. Agostinho, 2023, ACS chemical neuroscience.

Neurodegeneration in an Aβ‐induced model of Alzheimer’s disease: the role of Cdk5

P. Agostinho, C. Oliveira, J. P. Lopes, 2010, Aging cell.

Glutamate in life and death of retinal amacrine cells.

P. Agostinho, C. Duarte, A. Carvalho, 1998, General Pharmacology.

Stimulation of brain glucose uptake by cannabinoid CB2 receptors and its therapeutic potential in Alzheimer's disease

M. A. Pozo, S. Pasquaré, A. Köfalvi, 2016, Neuropharmacology.

Oxidative stress affects the selective ion permeability of voltage-sensitive Ca2+ channels in cultured retinal cells

P. Agostinho, C. Duarte, A. Carvalho, 1997, Neuroscience Research.

Astrocytic A2A receptors silencing negatively impacts hippocampal synaptic plasticity and memory of adult mice

P. Agostinho, R. Cunha, P. Canas, 2023, Glia.

Adenosine A2A receptors blockade attenuates dexamethasone-induced alterations in cultured astrocytes

P. Agostinho, R. Cunha, P. Canas, 2022, Purinergic Signalling.

Impact of blunting astrocyte activity on hippocampal synaptic plasticity in a mouse model of early Alzheimer's disease based on amyloid‐β peptide exposure

P. Agostinho, R. Cunha, J. P. Lopes, 2022, Journal of neurochemistry.

Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stress

C. Müller, M. Kaster, Â. R. Tomé, 2015, Proceedings of the National Academy of Sciences.

Enhanced role of adenosine A2A receptors in the modulation of LTP in the rat hippocampus upon ageing

P. Agostinho, R. Cunha, J. Marôco, 2011, The European journal of neuroscience.

Effects of Chronic Caffeine Consumption on Synaptic Function, Metabolism and Adenosine Modulation in Different Brain Areas

Samira G. Ferreira, Â. R. Tomé, P. Agostinho, 2023, Biomolecules.

Astrocytic adenosine A2A receptors control the amyloid-β peptide-induced decrease of glutamate uptake.

P. Agostinho, R. Cunha, Nuno J Machado, 2012, Journal of Alzheimer's disease : JAD.

Does Caffeine Consumption Modify Cerebrospinal Fluid Amyloid-β Levels in Patients with Alzheimer's Disease?

K. Blennow, M. Tsolaki, P. Agostinho, 2015, Journal of Alzheimer's disease : JAD.

INFLUENCE OF OXIDATIVE STRESS ON MEMBRANE POTENTIAL AND ON K+ CHANNELS IN NEURONAL CELLS

P. Agostinho, C. Duarte, C. Oliveira, 1995 .

Synaptic and sub-synaptic localization of amyloid-β protein precursor in the rat hippocampus.

P. Agostinho, R. Cunha, C. Oliveira, 2014, Journal of Alzheimer's disease : JAD.

Blockade of adenosine A2A receptors prevents interleukin-1β-induced exacerbation of neuronal toxicity through a p38 mitogen-activated protein kinase pathway

Â. R. Tomé, P. Agostinho, R. Cunha, 2012, Journal of Neuroinflammation.

Subsynaptic localization of nicotinic acetylcholine receptor subunits: A comparative study in the mouse and rat striatum

P. Agostinho, R. Cunha, C. Oliveira, 2014, Neuroscience Letters.

Prion Protein Aggregation and Neurotoxicity in Cortical Neurons

P. Agostinho, C. Oliveira, J. Melo, 2007, Annals of the New York Academy of Sciences.

[Neuroprotection strategies: effect of vinpocetine in vitro oxidative stress models].

P. Agostinho, P. Moreira, C. Oliveira, 2003, Acta medica portuguesa.

Exercise decreases aberrant corticostriatal plasticity in an animal model of L-DOPA-induced dyskinesia.

Samira G. Ferreira, Â. R. Tomé, P. Agostinho, 2021, American journal of physiology. Regulatory, integrative and comparative physiology.

The Association of Amyloid-β Protein Precursor With α- and β-Secretases in Mouse Cerebral Cortex Synapses Is Altered in Early Alzheimer’s Disease

P. Agostinho, R. Cunha, C. Oliveira, 2016, Molecular Neurobiology.

Cellular prion protein is present in dopaminergic neurons and modulates the dopaminergic system

P. Agostinho, R. Cunha, P. Dombrowski, 2014, The European journal of neuroscience.

Control of NMDA Receptor-Mediated Currents by Adenosine A1 and A2A Receptors Within the Basolateral Amygdala

Samira G. Ferreira, P. Agostinho, R. Cunha, 2020 .

l‐α‐aminoadipate causes astrocyte pathology with negative impact on mouse hippocampal synaptic plasticity and memory

P. Agostinho, R. Cunha, Catarina Leitão, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Adenosine A2A Receptor Up-Regulation Pre-Dates Deficits of Synaptic Plasticity and of Memory in Mice Exposed to Aβ1–42 to Model Early Alzheimer’s Disease

P. Agostinho, R. Cunha, J. P. Lopes, 2023, Biomolecules.

Cell cycle re-entry in Alzheimer's disease: a major neuropathological characteristic?

P. Agostinho, C. Oliveira, J. P. Lopes, 2009, Current Alzheimer research.

Mitochondria in Excitatory and Inhibitory Synapses have Similar Susceptibility to Amyloid-β Peptides Modeling Alzheimer's Disease.

Â. R. Tomé, P. Agostinho, R. Cunha, 2017, Journal of Alzheimer's disease : JAD.

Activity of Ionotropic Glutamate Receptors in Retinal Cells: Effect of Ascorbate/Fe2+‐Induced Oxidative Stress

P. Agostinho, C. Duarte, C. Oliveira, 1996, Journal of neurochemistry.

Overactivation of calcineurin induced by amyloid-beta and prion proteins

P. Agostinho, C. Oliveira, J. P. Lopes, 2008, Neurochemistry International.

Neurodegeneration in an Aβ‐induced model of Alzheimer’s disease: the role of Cdk5

P. Agostinho, C. Oliveira, J. P. Lopes, 2010, Aging cell.

Galantamine protects against oxidative stress induced by amyloid‐beta peptide in cortical neurons

P. Agostinho, C. Oliveira, J. Melo, 2009, The European journal of neuroscience.

The Association of Amyloid-β Protein Precursor With α- and β-Secretases in Mouse Cerebral Cortex Synapses Is Altered in Early Alzheimer’s Disease

P. Agostinho, R. Cunha, C. Oliveira, 2015, Molecular Neurobiology.

Oncostatin M promotes excitotoxicity by inhibiting glutamate uptake in astrocytes: implications in HIV-associated neurotoxicity

P. Agostinho, H. Boddeke, Sabita Roy, 2016, Journal of Neuroinflammation.

Modification of astrocytic Cx43 hemichannel activity in animal models of AD: modulation by adenosine A2A receptors

P. Agostinho, P. Canas, D. Madeira, 2023, Cellular and Molecular Life Sciences.

Adenosine A2A Receptor Blockade Provides More Effective Benefits at the Onset Rather than after Overt Neurodegeneration in a Rat Model of Parkinson’s Disease

P. Agostinho, P. Canas, Ana Nunes, 2024, International journal of molecular sciences.