Michiel Van Gool

发表

Identification of a novel orally bioavailable phosphodiesterase 10A (PDE10A) inhibitor with efficacy in animal models of schizophrenia.

A. Megens, X. Langlois, J. Bartolomé-Nebreda, 2015, Journal of medicinal chemistry.

Non-peptidic cell-penetrating agents: synthesis of oligomeric chiral bicyclic guanidinium vectors.

Michiel Van Gool, J. Sánchez-Quesada, P. Prados, 2012, Organic & biomolecular chemistry.

Rational design and synthesis of aminopiperazinones as β-secretase (BACE) inhibitors.

J. Spurlino, F. Delgado, Ó. Delgado, 2011, Bioorganic & medicinal chemistry letters.

A practical entry to β-aryl-β-alkyl amino alcohols: application to the synthesis of a potent BACE1 inhibitor.

Ó. Delgado, Michiel Van Gool, S. Fustero, 2012, Organic & biomolecular chemistry.

Highly efficient, nonpeptidic oligoguanidinium vectors that selectively internalize into mitochondria.

E. Giralt, Michiel Van Gool, P. Prados, 2005, Journal of the American Chemical Society.

Evaluation of a Series of β-Secretase 1 Inhibitors Containing Novel Heteroaryl-Fused-Piperazine Amidine Warheads.

Sergio A Alonso de Diego, Michiel Van Gool, G. Macdonald, 2019, ACS medicinal chemistry letters.

1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors: From Hit Generation to Orally Bioavailable Brain Penetrant Leads.

Ó. Delgado, Michiel Van Gool, J. M. Alonso, 2015, Journal of medicinal chemistry.

Diastereoselective synthesis of 2-phenyl-3-(trifluoromethyl)piperazines as building blocks for drug discovery.

Ó. Delgado, Michiel Van Gool, María Sánchez-Roselló, 2014, The Journal of organic chemistry.

Guanidinium receptors as enantioselective amino acid membrane carriers.

Michiel Van Gool, F. Gago, P. Prados, 2001, Journal of the American Chemical Society.

Dimerization inhibitors of HIV-1 protease based on a bicyclic guanidinium subunit.

Michiel Van Gool, P. Prados, B. Badet, 2003, Journal of Medicinal Chemistry.

A Brain-Penetrant and Bioavailable Pyrazolopiperazine BACE1 Inhibitor Elicits Sustained Reduction of Amyloid β In Vivo.

Michiel Van Gool, G. Macdonald, G. Tresadern, 2021, ACS medicinal chemistry letters.

Optimization of 1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors Toward a Clinical Candidate.

Michiel Van Gool, G. Macdonald, D. Moechars, 2018, Journal of medicinal chemistry.

A Versatile Approach to CF3 -Containing 2-Pyrrolidones by Tandem Michael Addition-Cyclization: Exemplification in the Synthesis of Amidine Class BACE1 Inhibitors.

Ó. Delgado, Michiel Van Gool, G. Tresadern, 2015, Chemistry.

Identification of Z-Tyr-Ala-CHN2, a Cathepsin L Inhibitor with Broad-Spectrum Cell-Specific Activity against Coronaviruses, including SARS-CoV-2

Michiel Van Gool, S. Ciesek, Christophe Buyck, 2023, Microorganisms.

A Versatile Approach to CF3 -Containing 2-Pyrrolidones by Tandem Michael Addition-Cyclization: Exemplification in the Synthesis of Amidine Class BACE1 Inhibitors.

Ó. Delgado, Michiel Van Gool, G. Tresadern, 2015, Chemistry.

A practical entry to β-aryl-β-alkyl amino alcohols: application to the synthesis of a potent BACE1 inhibitor.

Ó. Delgado, Michiel Van Gool, S. Fustero, 2012, Organic & biomolecular chemistry.

A flexible, image-based, high-throughput platform encompassing in-depth cell profiling to identify broad-spectrum coronavirus antivirals with limited off-target effects.

Michiel Van Gool, Christophe Buyck, M. Van Loock, 2023, Antiviral research.