D. Tulshian

发表

Potent, selective, and orally active adenosine A2A receptor antagonists: arylpiperazine derivatives of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines.

B. Neustadt, Jinsong Hao, N. Lindo, 2007, Bioorganic & medicinal chemistry letters.

Discovery of orally active pyrazoloquinolines as potent PDE10 inhibitors for the management of schizophrenia.

W. Greenlee, D. Tulshian, R. Hodgson, 2012, Bioorganic & medicinal chemistry letters.

Pyrazoloquinolines as PDE10A inhibitors: discovery of a tool compound.

W. Greenlee, D. Tulshian, R. Hodgson, 2012, Bioorganic & medicinal chemistry letters.

Novel pharmacological targets and progression of new antitussive drugs

D. Tulshian, J. Hey, R. Mcleod, 2003 .

Nociceptin inhibits cough in the guinea‐pig by activation of ORL1 receptors

R. Egan, D. Tulshian, J. Hey, 2001, British journal of pharmacology.

Constitutive activity of cannabinoid‐2 (CB2) receptors plays an essential role in the protean agonism of (+)AM1241 and L768242

D. Tulshian, A. Reggiani, M. Beltramo, 2009, British journal of pharmacology.

Nociceptin inhibits capsaicin-induced bronchoconstriction in isolated guinea pig lung.

R. Egan, D. Tulshian, M. Corboz, 2000, European journal of pharmacology.

Characterization of the nociceptin receptor (ORL-1) agonist, Ro64-6198, in tests of anxiety across multiple species

Walter A. Korfmacher, D. Tulshian, R. Hodgson, 2005, Psychopharmacology.

Antitussive Profile of the NOP Agonist Ro-64-6198 in the Guinea Pig

D. Tulshian, J. Hey, R. Mcleod, 2004, Pharmacology.

Pharmacological profile of the NOP agonist and cough suppressing agent SCH 486757 (8-[Bis(2-Chlorophenyl)Methyl]-3-(2-Pyrimidinyl)-8-Azabicyclo[3.2.1]Octan-3-Ol) in preclinical models.

Walter A. Korfmacher, D. Tulshian, J. Hey, 2010, European journal of pharmacology.

6-(2-Furanyl)-9H-purin-2-amine derivatives as A2A adenosine antagonists.

D. Tulshian, L. Arik, A. Fawzi, 2005, Bioorganic & medicinal chemistry letters.

The Anxiolytic-Like Effects of the Novel, Orally Active Nociceptin Opioid Receptor Agonist 8-[bis(2-Methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol (SCH 221510)

D. Tulshian, R. Hodgson, M. Graziano, 2008, Journal of Pharmacology and Experimental Therapeutics.

Structure-activity relationships of 2,4-diphenyl-1H-imidazole analogs as CB2 receptor agonists for the treatment of chronic pain.

W. Greenlee, D. Tulshian, K. Cox, 2011, Bioorganic & medicinal chemistry letters.

Where Are the New Cough Treatments: A Debriefing of Recent Clinical Proof-of-Concept Trials with the NOP Agonist SCH 486757

D. Tulshian, R. Mcleod, J. Sadeh, 2011, Pharmacology.

The anxiolytic-like profile of the nociceptin receptor agonist, endo-8-[bis(2-chlorophenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octane-3-carboxamide (SCH 655842): comparison of efficacy and side effects across rodent species.

Lynn A. Hyde, D. Tulshian, R. Hodgson, 2011, European journal of pharmacology.

The discovery and synthesis of novel adenosine receptor (A(2A)) antagonists.

B. Neustadt, Jinsong Hao, D. Tulshian, 2005, Bioorganic & medicinal chemistry letters.

The discovery of tropane derivatives as nociceptin receptor ligands for the management of cough and anxiety.

Walter A. Korfmacher, W. Greenlee, D. Tulshian, 2009, Bioorganic & medicinal chemistry letters.

Fused tricyclic mGluR1 antagonists for the treatment of neuropathic pain.

W. Greenlee, D. Tulshian, R. Bertorelli, 2012, Bioorganic & medicinal chemistry letters.

Stereoselective routes to some unsaturated α- and β-C-glycopyranosides

D. Tulshian, R. Dawe, B. Fraser-Reid, 1979 .

Routes From “Triacetyl Glucal” to 6-Deoxy-Hex-2-Enopyranosides

D. Tulshian, D. Kelly, B. Fraser-Reid, 1983 .

Out-of-ring Claisen rearrangements are highly stereoselective in pyranoses: routes to gem-dialkylated sugars

D. Tulshian, B. Fraser-Reid, R. Tsang, 1984 .

Routes to C-glycopyranosides via sigmatropic rearrangements

D. Tulshian, B. Fraser-Reid, 1984 .

A synthetic route to the C4 octadienic esters of trichothecenes from D-glucose

D. Tulshian, B. Fraser-Reid, 1981 .

The ready conversion of anguidine into verrucarol and trichodermol

D. Tulshian, B. Fraser-Reid, 1980 .

Total Synthesis of Griseolic Acid

D. Tulshian, M. Czarniecki, 1995 .

Total synthesis of griseolic acid derivatives from D-glucose

D. Tulshian, A. McPhail, J. DollRonald, 1991 .

Synthesis and SAR development of novel P2X7 receptor antagonists for the treatment of pain: part 2.

W. Greenlee, D. Tulshian, R. Bertorelli, 2011, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of potent and selective c-GMP phosphodiesterase inhibitors.

D. Tulshian, M. Czarniecki, M. Green, 1999, Bioorganic & medicinal chemistry letters.

Synthesis of a catechol metabolite of dilevalol

D. Tulshian, A. Bercovici, 1993 .

3H-[1,2,4]-Triazolo[5,1-i]purin-5-amine derivatives as adenosine A2A antagonists.

W. Greenlee, D. Tulshian, E. Ongini, 2007, Bioorganic & medicinal chemistry letters.

Striking contrasts in stereoselectivities of spiro-claisen rearrangements of pyranosides versus carbocycles.

D. Tulshian, B. Fraser-Reid, D. Lowe, 1984 .

Bioavailable pyrrolo-benzo-1,4-diazines as Na(v)1.7 sodium channel blockers for the treatment of pain.

D. Tulshian, R. J. Herr, Xianfeng Sun, 2014, Bioorganic & medicinal chemistry letters.

Discovery of pyrrolo-benzo-1,4-diazines as potent Na(v)1.7 sodium channel blockers.

D. Tulshian, R. J. Herr, D. Rindgen, 2014, Bioorganic & medicinal chemistry letters.

ROUTES FROM “TRIACETYLGLUCAL” TO 6-DEOXYHEX-2-ENOPYRANOSIDES

D. Tulshian, D. Kelly, B. Fraser-Reid, 1984 .

Studies directed at the synthesis of verrucarol from D-glucose: the A-B moiety

D. Tulshian, B. Fraser-Reid, 1984 .

Highly stereoselective routes to functionalized geminal alkyl derivatives of carbohydrates

D. Tulshian, B. Fraser-Reid, R. Tsang, 1981 .

Routes to C-glycopyranosides via sigmatropic rearrangements

D. Tulshian, B. Fraser-Reid, 1984 .

Synthesis and phosphodiesterase activity of carboxylic acid mimetics of cyclic guanosine 3',5'-monophosphate.

D. Tulshian, R. Doll, M. Czarniecki, 1993, Journal of Medicinal Chemistry.

Versatile synthesis of dihydroxy ? and d amino acids from carbohydrates

D. Tulshian, 1992 .

Discovery and hit-to-lead optimization of 2,6-diaminopyrimidine inhibitors of interleukin-1 receptor-associated kinase 4.

W. Greenlee, D. Tulshian, T. Fischmann, 2015, Bioorganic & medicinal chemistry letters.

SCH-202676: An allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors.

D. Tulshian, B. Weig, M. Graziano, 2001, Molecular pharmacology.

T-type calcium channel blockers: spiro-piperidine azetidines and azetidinones-optimization, design and synthesis.

W. Greenlee, D. Tulshian, D. Burnett, 2010, Bioorganic & medicinal chemistry letters.

Antiplatelet and antiproliferative effects of SCH 51866, a novel type 1 and type 5 phosphodiesterase inhibitor.

D. Tulshian, P. Chiu, M. Chintala, 1996, Journal of cardiovascular pharmacology.

Effect of a Novel NOP Receptor Agonist (SCH 225288) on Guinea Pig Irritant-Evoked, Feline Mechanically Induced and Canine Infectious Tracheobronchitis Cough

D. Tulshian, J. Hey, D. Bolser, 2009, Pharmacology.

Potent and Selective Amidopyrazole Inhibitors of IRAK4 That Are Efficacious in a Rodent Model of Inflammation.

D. Tulshian, T. Fischmann, C. Garlisi, 2015, ACS medicinal chemistry letters.

Synthesis and SAR development of novel mGluR1 antagonists for the treatment of chronic pain.

W. Greenlee, D. Tulshian, R. Bertorelli, 2012, Bioorganic & medicinal chemistry letters.

Antitussive effect of nociceptin/orphanin FQ in experimental cough models.

R. Egan, D. Tulshian, J. Hey, 2002, Pulmonary pharmacology & therapeutics.

Antitussive action of nociceptin in the cat.

D. Tulshian, J. Hey, D. Bolser, 2001, European journal of pharmacology.

The SAR development of dihydroimidazoisoquinoline derivatives as phosphodiesterase 10A inhibitors for the treatment of schizophrenia.

W. Greenlee, D. Tulshian, R. Hodgson, 2012, Bioorganic & medicinal chemistry letters.

The discovery of potent, selective, and orally active pyrazoloquinolines as PDE10A inhibitors for the treatment of Schizophrenia.

W. Greenlee, D. Tulshian, R. Hodgson, 2012, Bioorganic & medicinal chemistry letters.

Discovery of orally active 3-pyridinyl-tropane as a potent nociceptin receptor agonist for the management of cough.

W. Greenlee, D. Tulshian, J. Hey, 2009, Journal of medicinal chemistry.

Identification of 3-substituted N-benzhydryl-nortropane analogs as nociceptin receptor ligands for the management of cough and anxiety.

W. Greenlee, D. Tulshian, J. Hey, 2009, Bioorganic & medicinal chemistry letters.

2-(2-Furanyl)-7-phenyl[1,2,4]triazolo[1,5-c]pyrimidin-5-amine analogs: highly potent, orally active, adenosine A2A antagonists. Part 1.

D. Tulshian, G. Varty, A. Fawzi, 2005, Bioorganic & medicinal chemistry letters.

Discovery and Structure Enabled Synthesis of 2,6-Diaminopyrimidin-4-one IRAK4 Inhibitors.

D. Tulshian, T. Fischmann, C. Garlisi, 2015, ACS medicinal chemistry letters.

The Discovery and Synthesis of Novel Adenosine Receptor (A2A) Antagonists.

B. Neustadt, Jinsong Hao, D. Tulshian, 2005 .

Discovery of pyrrolo-benzo-1,4-diazines as potent Na(v)1.7 sodium channel blockers.

D. Tulshian, D. Rindgen, Shu-wei Yang, 2014, Bioorganic & medicinal chemistry letters.

Efforts towards the optimization of a bi-aryl class of potent IRAK4 inhibitors.

D. Tulshian, C. Garlisi, W. M. Seganish, 2016, Bioorganic & medicinal chemistry letters.

Synthesis and SAR development of novel P2X7 receptor antagonists for the treatment of pain: part 2.

W. Greenlee, D. Tulshian, R. Bertorelli, 2011, Bioorganic & medicinal chemistry letters.

Initial optimization and series evolution of diaminopyrimidine inhibitors of interleukin-1 receptor associated kinase 4.

W. Greenlee, D. Tulshian, Jinhai Yang, 2015, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1.

W. Greenlee, D. Tulshian, A. Fawzi, 2007, Bioorganic & medicinal chemistry letters.

Lynn A. Hyde, D. Tulshian, R. Hodgson, 2011, European journal of pharmacology.

Structure-activity relationships of 3-substituted N-benzhydryl-nortropane analogs as nociceptin receptor ligands for the treatment of cough.

W. Greenlee, D. Tulshian, Shu-wei Yang, 2008, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2.

W. Greenlee, D. Tulshian, R. Mcleod, 2007, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationships of N-substituted spiropiperidines as nociceptin receptor ligands.

D. Tulshian, A. Fawzi, Hongtao Zhang, 2007, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationships of N-substituted spiropiperidines as nociceptin receptor ligands: part 2.

D. Tulshian, R. Mcleod, A. Fawzi, 2009, Bioorganic & medicinal chemistry letters.