J. Gut

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Application of multicomponent reactions to antimalarial drug discovery. Part 2: New antiplasmodial and antitrypanosomal 4-aminoquinoline gamma- and delta-lactams via a 'catch and release' protocol.

V. Yardley, C. Musonda, J. Gut, 2006, Bioorganic & medicinal chemistry.

Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity.

J. Gut, P. Rosenthal, R. Guedes, 2010, Journal of medicinal chemistry.

Identification of new antimalarial leads by use of virtual screening against cytochrome bc₁.

Rui Moreira, Rita C Guedes, Jiri Gut, 2011, Bioorganic & medicinal chemistry.

Chemical genetics of Plasmodium falciparum

Anang A. Shelat, David S. Roos, John S. Lazo, 2010, Nature.

Coupling the Antimalarial Cell Penetrating Peptide TP10 to Classical Antimalarial Drugs Primaquine and Chloroquine Produces Strongly Hemolytic Conjugates

J. Gut, P. Rosenthal, D. Andreu, 2019, Molecules.

Tetracyclines Specifically Target the Apicoplast of the Malaria Parasite Plasmodium falciparum

Joseph L. DeRisi, Philip J. Rosenthal, Jiri Gut, 2006, Antimicrobial Agents and Chemotherapy.

Identification of novel parasitic cysteine protease inhibitors using virtual screening. 1. The ChemBridge database.

Jiri Gut, Prashant V Desai, Mitchell Avery, 2004, Journal of medicinal chemistry.

Synthesis, biological evaluation, hydration site thermodynamics, and chemical reactivity analysis of α-keto substituted peptidomimetics for the inhibition of Plasmodium falciparum.

J. Gut, P. Rosenthal, W. Sherman, 2014, Bioorganic & medicinal chemistry letters.

Chemical–biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target

A. Burlingame, J. Taunton, J. Gut, 2013, Beilstein journal of organic chemistry.

Lead Identification to Clinical Candidate Selection

F. Supek, J. Gut, A. Renslo, 2015, Journal of biomolecular screening.

Conversion of leukotriene A4 to leukotriene B4: catalysis by human liver microsomes under anaerobic conditions.

J. Gut, J. Trudell, G. Jamieson, 1987, Archives of biochemistry and biophysics.

The design, synthesis, in silico ADME profiling, antiplasmodial and antimycobacterial evaluation of new arylamino quinoline derivatives.

J. Gut, P. Rosenthal, K. Chibale, 2012, European journal of medicinal chemistry.

Design, synthesis and anti-plasmodial evaluation in vitro of new 4-aminoquinoline isatin derivatives.

Kelly Chibale, Jiri Gut, Idan Chiyanzu, 2005, Bioorganic & medicinal chemistry.

[(7-chloroquinolin-4-yl)amino]acetophenones and their copper(II) derivatives: Synthesis, characterization, computational studies and antimalarial activity

J. Gut, P. Rosenthal, J. Charris, 2019, EXCLI journal.

β-amino-alcohol tethered 4-aminoquinoline-isatin conjugates: Synthesis and antimalarial evaluation

Nisha, Vipan Kumar, J. Gut, 2014, European Journal of Medicinal Chemistry.

Azide-alkyne cycloaddition en route to 1H-1,2,3-triazole-tethered 7-chloroquinoline-isatin chimeras: synthesis and antimalarial evaluation.

Vipan Kumar, J. Gut, P. Rosenthal, 2013, European journal of medicinal chemistry.

Novel thiolactone-isatin hybrids as potential antimalarial and antitubercular agents.

J. Gut, P. Rosenthal, K. Chibale, 2011, Bioorganic & medicinal chemistry letters.

Comparison of the antiplasmodial and falcipain-2 inhibitory activity of beta-amino alcohol thiolactone-chalcone and isatin-chalcone hybrids.

J. Gut, P. Rosenthal, K. Chibale, 2010, Bioorganic & medicinal chemistry letters.

Cryptolepine analogues containing basic aminoalkyl side-chains at C-11: synthesis, antiplasmodial activity, and cytotoxicity.

J. Gut, P. Rosenthal, J. Lavrado, 2008, Bioorganic & medicinal chemistry letters.

Design, synthesis, and antimalarial activity of structural chimeras of thiosemicarbazone and ferroquine analogues.

J. Gut, P. Rosenthal, K. Chibale, 2007, Bioorganic & medicinal chemistry letters.

Antiparasitic activities of novel, orally available fumagillin analogs.

Anjan Debnath, Joseph L DeRisi, Jiri Gut, 2009, Bioorganic & medicinal chemistry letters.

Repurposing Auranofin as a Lead Candidate for Treatment of Lymphatic Filariasis and Onchocerciasis

Brian M. Suzuki, J. Gut, M. Arkin, 2015, PLoS neglected tropical diseases.

Anti-plasmodial and antioxidant activities of constituents of the seed shells of Symphonia globulifera Linn f.

J. Gut, P. Rosenthal, J. D. Connolly, 2006, Phytochemistry.

Antimalarial prenylated chalcones from the twigs of Dorstenia barteri var. subtriangularis

J. Gut, P. Rosenthal, F. Boyom, 2007 .

Endodesmiadiol, a friedelane triterpenoid, and other antiplasmodial compounds from Endodesmia calophylloides.

J. Gut, P. Rosenthal, M. Rohmer, 2008, Chemical & pharmaceutical bulletin.

Falcipain Inhibitors Based on the Natural Product Gallinamide A Are Potent in Vitro and in Vivo Antimalarials.

J. Gut, P. Rosenthal, R. Payne, 2019, Journal of medicinal chemistry.

Synthesis of gallinamide A analogues as potent falcipain inhibitors and antimalarials.

J. Gut, P. Rosenthal, R. Payne, 2014, Journal of medicinal chemistry.

Critical role of amino acid 23 in mediating activity and specificity of vinckepain-2, a papain-family cysteine protease of rodent malaria parasites.

C. Craik, J. Gut, P. Rosenthal, 2002, The Biochemical journal.

Endoperoxide-8-aminoquinoline hybrids as dual-stage antimalarial agents with enhanced metabolic stability.

J. Gut, P. Rosenthal, R. Moreira, 2018, European journal of medicinal chemistry.

Novel endoperoxide-based transmission-blocking antimalarials with liver- and blood-schizontocidal activities.

J. Gut, P. Rosenthal, M. Mota, 2014, ACS medicinal chemistry letters.

Tetraoxane-pyrimidine nitrile hybrids as dual stage antimalarials.

J. Gut, P. Rosenthal, Lídia M D Gonçalves, 2014, Journal of medicinal chemistry.

1,4-naphthoquinone cations as antiplasmodial agents: hydroxy-, acyloxy-, and alkoxy-substituted analogues.

J. Gut, P. Rosenthal, T. Long, 2012, ACS medicinal chemistry letters.

Synthesis, Antiplasmodial Activity, and β-Hematin Inhibition of Hydroxypyridone-Chloroquine Hybrids.

J. Gut, P. Rosenthal, K. Chibale, 2013, ACS medicinal chemistry letters.

Phosphonium lipocations as antiparasitic agents.

J. Gut, P. Rosenthal, T. Long, 2012, Bioorganic & medicinal chemistry letters.

Cloning and Sequence Analysis of a Highly Polymorphic Cryptosporidium parvum Gene Encoding a 60-Kilodalton Glycoprotein and Characterization of Its 15- and 45-Kilodalton Zoite Surface Antigen Products

J. Gut, W. Strong, R. Nelson, 2000, Infection and Immunity.

Identification and isolation of Cryptosporidium parvum genes encoding microtubule and microfilament proteins.

J. Gut, C. Petersen, R. Nelson, 1991, The Journal of protozoology.

Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds.

J. Gut, P. Rosenthal, K. Chibale, 2010, Bioorganic & medicinal chemistry.

Design, synthesis and biological evaluation of novel benzothiazole and triazole analogs as falcipain inhibitors

Mitchell A. Avery, Falgun Shah, Philip J. Rosenthal, 2011 .

Oxygen concentration-dependent metabolism of leukotriene B4 by hepatocyte monolayers.

J. Gut, J. Trudell, A. K. Costa, 1986, Biochimica et biophysica acta.

Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis

J. Gut, C. Huston, J. Plattner, 2019, Nature Communications.

Synthesis and structure-activity relationships of novel benzoxaboroles as a new class of antimalarial agents.

J. Gut, P. Rosenthal, F. Gamo, 2011, Bioorganic & medicinal chemistry letters.

Probing the aurone scaffold against Plasmodium falciparum: design, synthesis and antimalarial activity.

Ana S. Newton, J. Gut, Lídia M D Gonçalves, 2014, European journal of medicinal chemistry.

A Reprofiled Drug, Auranofin, Is Effective against Metronidazole-Resistant Giardia lamblia

J. Gut, L. Eckmann, J. McKerrow, 2013, Antimicrobial Agents and Chemotherapy.

Enantioselective Synthesis and in Vivo Evaluation of Regioisomeric Analogues of the Antimalarial Arterolane

J. Gut, P. Rosenthal, A. Renslo, 2017, Journal of medicinal chemistry.

Ferrous iron-dependent delivery of therapeutic agents to the malaria parasite.

J. Gut, P. Rosenthal, A. Renslo, 2012, Future medicinal chemistry.

4-Aminoquinoline-chalcone/-N-acetylpyrazoline conjugates: Synthesis and antiplasmodial evaluation.

Vipan Kumar, J. Gut, P. Rosenthal, 2017, European journal of medicinal chemistry.

Synthesis and in vitro antiplasmodial evaluation of 7-chloroquinoline-chalcone and 7-chloroquinoline-ferrocenylchalcone conjugates.

Vipan Kumar, J. Gut, P. Rosenthal, 2015, European journal of medicinal chemistry.

Targeting the Erythrocytic and Liver Stages of Malaria Parasites with s‐Triazine‐Based Hybrids

J. Gut, R. Moreira, C. Afonso, 2015, ChemMedChem.

Drug Delivery to the Malaria Parasite Using an Arterolane‐Like Scaffold

J. Gut, P. Rosenthal, A. Renslo, 2015, ChemMedChem.

1H-1,2,3-Triazole-tethered isatin-7-chloroquinoline and 3-hydroxy-indole-7-chloroquinoline conjugates: synthesis and antimalarial evaluation.

Vipan Kumar, J. Gut, P. Rosenthal, 2014, Bioorganic & medicinal chemistry letters.

4‐Aminoquinoline‐β‐Lactam Conjugates: Synthesis, Antimalarial, and Antitubercular Evaluation

Vipan Kumar, J. Gut, P. Rosenthal, 2014, Chemical biology & drug design.

Cinnamic Acid/Chloroquinoline Conjugates as Potent Agents against Chloroquine‐Resistant Plasmodium falciparum

J. Gut, P. Rosenthal, J. Gomes, 2012, ChemMedChem.

Artemisinin-dipeptidyl vinyl sulfone hybrid molecules: design, synthesis and preliminary SAR for antiplasmodial activity and falcipain-2 inhibition.

J. Gut, P. Rosenthal, Lídia M D Gonçalves, 2009, Bioorganic & medicinal chemistry letters.

Trioxolane-Mediated Delivery of Mefloquine Limits Brain Exposure in a Mouse Model of Malaria.

M. Bogyo, J. Gut, P. Rosenthal, 2015, ACS medicinal chemistry letters.

Microwave-promoted facile access to 4-aminoquinoline-phthalimides: Synthesis and anti-plasmodial evaluation.

Vipan Kumar, J. Gut, P. Rosenthal, 2018, European journal of medicinal chemistry.

PRIMACENES: novel non-cytotoxic primaquine-ferrocene conjugates with anti-Pneumocystis carinii activity

J. Gut, P. Rosenthal, R. Moreira, 2010 .

New cis‐Configured Aziridine‐2‐carboxylates as Aspartic Acid Protease Inhibitors

J. Gut, P. Rosenthal, G. Bringmann, 2011, ChemMedChem.

Leukotriene biosynthesis: direct chemical ionization mass spectrometry of underivatized arachidonic acid metabolites.

J. Gut, J. Trudell, G. Jamieson, 1988, Biomedical & environmental mass spectrometry.

A novel multi-domain mucin-like glycoprotein of Cryptosporidium parvum mediates invasion.

J. Gut, J. Wu, J. Dubremetz, 1998, Molecular and biochemical parasitology.

Diversity-oriented synthesis yields a new drug lead for treatment of chagas disease.

Jeremy R. Duvall, S. Schreiber, Ana Rodriguez, 2014, ACS medicinal chemistry letters.

Identification of Diversity-Oriented Synthesis Derived Small Molecule, ML341, with Cidal Activity Against Trypanosoma cruzi

Ana Rodriguez, J. Gut, B. Muñoz, 2013 .

4-Aminoquinoline-ferrocenyl-chalcone conjugates: Synthesis and anti-plasmodial evaluation.

Vipan Kumar, J. Gut, P. Rosenthal, 2017, European journal of medicinal chemistry.

Synthesis of chlorovinyl sulfones as structural analogs of chalcones and their antiplasmodial activities.

J. Gut, P. Rosenthal, J. Domínguez, 2009, European journal of medicinal chemistry.

Synthesis and evaluation of sulfonylurea derivatives as novel antimalarials.

J. Gut, P. Rosenthal, J. Charris, 2007, European journal of medicinal chemistry.

Synthesis and antimalarial activity of sulfonamide chalcone derivatives.

J. Gut, P. Rosenthal, J. Domínguez, 2005, Farmaco.

Dipeptide vinyl sultams: synthesis via the Wittig-Horner reaction and activity against papain, falcipain-2 and Plasmodium falciparum.

J. Gut, P. Rosenthal, R. Guedes, 2006, Bioorganic & medicinal chemistry letters.

PRIMACINS, N-cinnamoyl-primaquine conjugates, with improved liver-stage antimalarial activity

J. Gut, P. Rosenthal, M. Prudêncio, 2012 .

Imidazolidin-4-one peptidomimetic derivatives of primaquine: synthesis and antimalarial activity.

J. Gut, P. Rosenthal, V. do Rosário, 2008, Bioorganic & medicinal chemistry letters.

Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones.

J. Gut, P. Rosenthal, R. Moreira, 2008, Bioorganic & medicinal chemistry letters.

Quantification of 5- and 15-HPETE's by direct chemical ionization mass spectrometry.

J. Gut, J. Trudell, G. Jamieson, 1987, Free radical biology & medicine.

Properties of enzymes in hepatocytes that convert 5-HPETE or LTA4 into LTB4.

J. Gut, J. Trudell, 1989, Free radical biology & medicine.

Platinum(II) and gold(I) complexes based on 1,1′-bis(diphenylphosphino)metallocene derivatives: Synthesis, characterization and biological activity of the gold complexes

Lara C. Spencer, J. Gut, P. Rosenthal, 2012 .

Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain.

J. Gut, P. Rosenthal, R. Guy, 2005, Bioorganic & medicinal chemistry letters.

Hsp90 Inhibitors as New Leads To Target Parasitic Diarrheal Diseases

J. Gut, A. Renslo, L. Eckmann, 2014, Antimicrobial Agents and Chemotherapy.

An image-based assay for high throughput screening of Giardia lamblia.

J. Gut, P. Rosenthal, M. Arkin, 2011, Journal of microbiological methods.

Incorporation of basic side chains into cryptolepine scaffold: structure-antimalarial activity relationships and mechanistic studies.

J. Gut, P. Rosenthal, M. Mota, 2011, Journal of medicinal chemistry.

Tetrafluorophenoxymethyl ketone cruzain inhibitors with improved pharmacokinetic properties as therapeutic leads for Chagas' disease.

J. Gut, A. Renslo, M. Arkin, 2015, Bioorganic & medicinal chemistry letters.

Nucleic acids components and their analogues. XCI. An improved synthesis of 6-azauracil and its 5-substituted derivatives

J. Gut, J. Farkas, M. Bobek, 1967 .

Design and synthesis of novel 2-pyridone peptidomimetic falcipain 2/3 inhibitors.

J. Gut, P. Rosenthal, Peter D Gibbons, 2008, Bioorganic & medicinal chemistry letters.

Application of multi-component reactions to antimalarial drug discovery. Part 1: Parallel synthesis and antiplasmodial activity of new 4-aminoquinoline Ugi adducts.

C. Musonda, J. Gut, P. Rosenthal, 2004, Bioorganic & medicinal chemistry letters.

Imidazoquines as antimalarial and antipneumocystis agents.

J. Gut, P. Rosenthal, M. Mota, 2009, Journal of medicinal chemistry.

Synthesis, Structure and in Vitro Biological Screening of Palladium(II) Complexes of Functionalised Salicylaldimine Thiosemicarbazones as Antimalarial and Anticancer Agents

J. Gut, P. Rosenthal, K. Chibale, 2010 .

7‐Chloroquinoline–isatin Conjugates: Antimalarial, Antitubercular, and Cytotoxic Evaluation

Vipan Kumar, J. Gut, C. Biot, 2014, Chemical biology & drug design.

Bis-alkylamine quindolone derivatives as new antimalarial leads.

J. Gut, P. Rosenthal, J. Lavrado, 2010, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi.

Kelly Chibale, Jiri Gut, J. Gut, 2004, Journal of medicinal chemistry.

Tetrazole-based deoxyamodiaquines: synthesis, ADME/PK profiling and pharmacological evaluation as potential antimalarial agents.

J. Gut, P. Rosenthal, K. Chibale, 2013, Bioorganic & medicinal chemistry.

N-cinnamoylated chloroquine analogues as dual-stage antimalarial leads.

J. Gut, P. Rosenthal, J. Gomes, 2013, Journal of medicinal chemistry.

Antiplasmodial and cytotoxicity evaluation of 3-functionalized 2-azetidinone derivatives.

Vipan Kumar, M. P. Mahajan, J. Gut, 2011, Bioorganic & medicinal chemistry letters.

Nucleic acids components and their analogues. III. Antimicrobial effect of some pyrimidine analogues and related compounds

F. Šorm, J. Gut, C. Párkányi, 1959 .

Enone- and chalcone-chloroquinoline hybrid analogues: in silico guided design, synthesis, antiplasmodial activity, in vitro metabolism, and mechanistic studies.

J. Gut, P. Rosenthal, K. Chibale, 2011, Journal of medicinal chemistry.

Synthesis and evaluation of new antimalarial phenylurenyl chalcone derivatives.

Jiri Gut, J. Gut, P. Rosenthal, 2005, Journal of medicinal chemistry.

Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain.

Kelly Chibale, Jiri Gut, Idan Chiyanzu, 2003, Bioorganic & medicinal chemistry letters.

In vitro efficiency of 9-(N-cinnamoylbutyl)aminoacridines against blood- and liver-stage malaria parasites.

J. Gut, P. Rosenthal, M. Prudêncio, 2013, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of phenolic Mannich bases of benzaldehyde and (thio)semicarbazone derivatives against the cysteine protease falcipain-2 and a chloroquine resistant strain of Plasmodium falciparum.

J. Gut, P. Rosenthal, K. Chibale, 2007, Bioorganic & medicinal chemistry.

Synthesis, antimalarial and antitubercular activity of acetylenic chalcones.

Kelly Chibale, Jiri Gut, J. Gut, 2010, Bioorganic & medicinal chemistry letters.

Urea/oxalamide tethered β-lactam-7-chloroquinoline conjugates: synthesis and in vitro antimalarial evaluation.

Vipan Kumar, J. Gut, P. Rosenthal, 2014, European journal of medicinal chemistry.

Design and Evaluation of Primaquine-Artemisinin Hybrids as a Multistage Antimalarial Strategy

J. Gut, P. Rosenthal, M. Mota, 2011, Antimicrobial Agents and Chemotherapy.

Antiplasmodial activity of extracts from seven medicinal plants used in malaria treatment in Cameroon.

J. Gut, P. Rosenthal, Vincent Ngouana, 2009, Journal of ethnopharmacology.

Synthesis and in vitro evaluation of gold(I) thiosemicarbazone complexes for antimalarial activity.

J. Gut, P. Rosenthal, K. Chibale, 2010, Journal of inorganic biochemistry.

Ferrocenylthiosemicarbazones conjugated to a poly(propyleneimine) dendrimer scaffold: Synthesis and in vitro antimalarial activity

J. Gut, P. Rosenthal, K. Chibale, 2011 .

AZA ANALOGS OF PYRIMIDINE AND PURINE BASES OF NUCLEIC ACIDS.

J. Gut, 1963, Advances in heterocyclic chemistry.

Synthesis and in vitro antimalarial and antitubercular activity of gold(III) complexes containing thiosemicarbazone ligands

J. Gut, P. Rosenthal, K. Chibale, 2011 .

Novel squaramides with in vitro liver stage antiplasmodial activity.

Maria M. M. Santos, J. Gut, P. Rosenthal, 2016, Bioorganic & medicinal chemistry.

Squaric acid/4-aminoquinoline conjugates: novel potent antiplasmodial agents.

Maria M. M. Santos, J. Gut, P. Rosenthal, 2013, European journal of medicinal chemistry.

Squaric acid : a valuable scaffold for developing antimalarials?

Maria M. M. Santos, J. Gut, P. Rosenthal, 2012 .

Potent antiplasmodial extracts from Cameroonian Annonaceae.

P. Fokou, J. Gut, P. Rosenthal, 2011, Journal of ethnopharmacology.

Design, synthesis and structure-activity relationships of (1H-pyridin-4-ylidene)amines as potential antimalarials.

J. Gut, P. Rosenthal, R. Guedes, 2009, Bioorganic & medicinal chemistry letters.

Anti-plasmodial activity of some constituents of the root bark of Harungana madagascariensis LAM. (Hypericaceae).

J. Gut, P. Rosenthal, F. Fekam Boyom, 2007, Chemical & pharmaceutical bulletin.

Antimalarial Compounds from the Stem Bark of Vismia laurentii

J. Gut, C. Antheaume, F. Boyom, 2009, Zeitschrift fur Naturforschung. C, Journal of biosciences.

Antiplasmodial Activity of Some Constituents of the Root Bark of Harungana madagascariensis Lam. (Hypericaceae).

J. Gut, P. Rosenthal, J. D. Connolly, 2007 .

Composition and anti-plasmodial activities of essential oils from some Cameroonian medicinal plants.

J. Gut, P. Rosenthal, J. Bessière, 2003, Phytochemistry.

Design, synthesis, and development of novel guaianolide-endoperoxides as potential antimalarial agents.

Falgun Shah, Jiri Gut, Yunshan Wu, 2010, Journal of medicinal chemistry.

Antiplasmodial volatile extracts from Cleistopholis patens Engler & Diels and Uvariastrum pierreanum Engl. (Engl. & Diels) (Annonaceae) growing in Cameroon

J. Gut, P. Rosenthal, J. Bessière, 2010, Parasitology Research.

N10,N11-di-alkylamine indolo[3,2-b]quinolines as hemozoin inhibitors: design, synthesis and antiplasmodial activity.

J. Gut, P. Rosenthal, T. Egan, 2015, Bioorganic & medicinal chemistry.

Bis-alkylamine Indolo[3,2-b]quinolines as hemozoin ligands: implications for antimalarial cytostatic and cytocidal activities.

J. Gut, P. Rosenthal, J. Lavrado, 2014, Journal of medicinal chemistry.

4-Aminopyridyl-Based CYP51 Inhibitors as Anti-Trypanosoma cruzi Drug Leads with Improved Pharmacokinetic Profile and in Vivo Potency

J. Gut, J. McKerrow, M. Cameron, 2014, Journal of medicinal chemistry.

Diverse Inhibitor Chemotypes Targeting Trypanosoma cruzi CYP51

Michelle R. Arkin, Joseph Mulvaney, Jiri Gut, 2012, PLoS neglected tropical diseases.

Extracts from Annona Muricata L. and Annona Reticulata L. (Annonaceae) Potently and Selectively Inhibit Plasmodium Falciparum

P. Fokou, J. Gut, P. Rosenthal, 2015, Medicines.

Isolation, sequence and molecular karyotype analysis of the actin gene of Cryptosporidium parvum.

J. Gut, C. Petersen, R. Nelson, 1992, Molecular and biochemical parasitology.

Morphology of the nematode Capillaria pterophylli Heinze, 1933, a pathogenic parasite of some aquarium fishes.

J. Gut, F. Moravec, 1982 .

Monoclonal Antibodies Identify a Subset of Dense Granules in Cryptosporidium parvum Zoites and Gamonts

J. Gut, J. Dubremetz, P. Camerlynck, 1995, The Journal of eukaryotic microbiology.

Cryptosporidium parvum: synchronized excystation in vitro and evaluation of sporozoite infectivity with a new lectin-based assay.

J. Gut, R. Nelson, Nelson Rg, 1999, The Journal of eukaryotic microbiology.

Potential antifolate resistance determinants and genotypic variation in the bifunctional dihydrofolate reductase-thymidylate synthase gene from human and bovine isolates of Cryptosporidium parvum.

J. Gut, C. Petersen, R. Nelson, 1996, Molecular and biochemical parasitology.

Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis

J. Gut, C. Huston, J. Plattner, 2019, Nature Communications.

Characterization of a > 900,000-M(r) Cryptosporidium parvum sporozoite glycoprotein recognized by protective hyperimmune bovine colostral immunoglobulin

J. Gut, C. Petersen, P. Doyle, 1992, Infection and immunity.

Identification and initial characterization of five Cryptosporidium parvum sporozoite antigen genes

J. Gut, C. Petersen, J. Leech, 1992, Infection and immunity.

Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites

J. Gut, P. Rosenthal, D. Wirth, 2016, ChemMedChem.

Nucleic acid components and their analogues. XX. Synthesis of oxonic acid (2,4-dioxo-1,2,3,4-tetrahydro-1,3,5-triazine-6-carboxylic acid) and the acetylation of 2,4-dioxohexahydro-1,3,5-triazines

J. Gut, A. Pískala, 1962 .

Piperazine‐linked 4‐aminoquinoline‐chalcone/ferrocenyl‐chalcone conjugates: Synthesis and antiplasmodial evaluation

Vipan Kumar, J. Gut, P. Rosenthal, 2017, Chemical biology & drug design.

Identification of Novel Malarial Cysteine Protease Inhibitors Using Structure-Based Virtual Screening of a Focused Cysteine Protease Inhibitor Library

Mitchell A. Avery, Prasenjit Mukherjee, Falgun Shah, 2011, J. Chem. Inf. Model..

Binding Mode and Potency of N-Indolyloxopyridinyl-4-aminopropanyl-Based Inhibitors Targeting Trypanosoma cruzi CYP51

J. Gut, J. McKerrow, M. Cameron, 2014, Journal of medicinal chemistry.

Nucleic acid components and their analogues. XLIX. Tautomeric structure of 6-azacytosine and its derivatives

J. Gut, J. Jonas, J. Pitha, 1964 .

Mesoionic dimethyl derivatives of some 1,2,4-triazinones. The course of the reaction of 3,5-dimethoxy, 3-methoxy-5-methylthio, 5-methoxy-3-methylthio and 3,5-bis(methylthio)-1,2,4-triazine with methyl iodide

J. Gut, M. Masojídková, D. Šaman, 1993 .

Preparation of 3- and 3,5-substituted 1,2,4-triazoles

J. Gut, T. Vanek, V. Velková, 1985 .

Mesoionic Dimethyl Derivatives of Some 1,2,4-Triazinones. The Course of the Reaction of 3,5-Dimethoxy, 3-Methoxy-5-methylthio, 5-Methoxy-3- methylthio and 3,5-Bis(methylthio)-1,2,4-triazine with Methyl Iodide.

J. Gut, M. Masojídková, D. Šaman, 1994 .

Preparation and the tautometric structure of 3-methoxy-1,2,4-triazin-5-one and 5-methoxy-1,2,4-triazin-3-one

J. Gut, A. Pískala, P. Fiedler, 1975 .

Chemistry of 1,2,4-triazine. IV. Methylation of 2,3,4,5-tetrahydro-1,2,4-triazine-3,5-dione with dimethyl sulfate in neutral media

J. Gut, V. Uchytilová, M. Prystaš, 1973 .

Nucleic acid components and their analogues. XXIV. Ultraviolet spectra and dissociation constants of 6-azauracil thioxo derivatives

J. Gut, J. Jonas, 1962 .

Nucleic acid components and their analogues. X. Methyl derivatives of 6-azauracil thioxo analogues

J. Gut, M. Prystaš, J. Jonas, 1961 .

Nucleic acids components and their analogues. XI. Infrared spectroscopy of uracil, 8-azauracil and their derivatives in the carbonyl group stretching vibration region

J. Gut, M. Horák, 1961 .

Nucleic acid components and their analogues. IX. N-Methyl derivatives of 6-azauracil and 6-azathymine

F. Šorm, J. Gut, M. Prystaš, 1961 .

Nucleic acids components and their analogues. XII. Electronic absorption spectra of 6-azauracil and related compounds

J. Gut, J. Jonas, 1961 .

The effect of N-methyl-thio-, and methylmercaptoderivatives of 6-azauracil on vaccinia virus in vitro.

F. Šorm, J. Gut, F. Šmejkal, 1962, Acta virologica.

Nucleic acid components and their analogues. XXVI. Ultraviolet and infrared spectra of 5-azauracil and related compounds

J. Gut, A. Pískala, J. Jonas, 1962 .

Nucleic acid components and their analogues. XVII. Reaction of uracil and of its aza analogues with ethylene carbonate

J. Gut, M. Prystaš, 1962 .

Impact of Antimalarial Treatment and Chemoprevention on the Drug Sensitivity of Malaria Parasites Isolated from Ugandan Children

J. Gut, P. Rosenthal, D. Havlir, 2015, Antimicrobial Agents and Chemotherapy.

Nucleic acid components and their analogues. XIII. Synthesis of 5-azauracil (allantoxaidin) and its N-methyl derivatives

J. Gut, A. Pískala, 1961 .

Nucleic acids components and their analogues. LXXXII. The fine structure of 6-azaisocytosine and its derivatives

J. Gut, P. Fiedler, J. Pitha, 1966 .

Nucleic acid components and their analogues. XXIII. Inhibition of growth of Escherichia coli by derivatives of pyrimidine, 5-azauracil, 6-azauracil and some simpler models of these derivatives

F. Šorm, J. Gut, C. Párkányi, 1962 .

CHEMISTRY OF 1,2,4-TRIAZINE PART 6, PREPARATION AND THE TAUTOMERIC STRUCTURE OF 3-METHOXY-1,2,4-TRIAZIN-5-ONE AND 5-METHOXY-1,2,4-TRIAZIN-3-ONE

J. Gut, A. Pískala, P. Fiedler, 1975 .

Expression and characterization of the Plasmodium falciparum haemoglobinase falcipain-3.

Ashutosh Kumar Singh, J. Gut, P. Rosenthal, 2001, The Biochemical journal.

Antimalarial Trioxolanes with Superior Drug-Like Properties and In Vivo Efficacy.

J. Gut, P. Rosenthal, A. Renslo, 2020, ACS infectious diseases.

Antimalarial Activity of Human Immunodeficiency Virus Type 1 Protease Inhibitors

J. Gut, P. Rosenthal, E. Istvan, 2005, Antimicrobial Agents and Chemotherapy.

Structural optimization of quinolon-4(1H)-imines as dual-stage antimalarials: toward increased potency and metabolic stability.

J. Gut, P. Rosenthal, M. Mota, 2013, Journal of medicinal chemistry.

WormAssay: A Novel Computer Application for Whole-Plate Motion-based Screening of Macroscopic Parasites

Jiri Gut, K. C. Lim, J. Gut, 2012, PLoS neglected tropical diseases.

Effectiveness of methods used for the detection of sarcosporidiosis in farm animals.

J. Gut, 1982, Folia parasitologica.

Efficacy of subcutaneous doses and a new oral amorphous solid dispersion formulation of flubendazole on male jirds (Meriones unguiculatus) infected with the filarial nematode Brugia pahangi

J. Gut, B. Beerntsen, S. Lustigman, 2019, PLoS neglected tropical diseases.

Aza vinyl sulfones: synthesis and evaluation as antiplasmodial agents.

Maria M. M. Santos, J. Gut, P. Rosenthal, 2011, Bioorganic & medicinal chemistry.

Synthesis and in vitro and in vivo pharmacological evaluation of new 4-aminoquinoline-based compounds.

J. Gut, P. Rosenthal, K. Chibale, 2013, ACS medicinal chemistry letters.

Design, Synthesis and Evaluation of Trisubstituted Thiazoles Targeting Plasmodium Falciparum Cysteine Proteases

Mitchell A. Avery, Prashant V. Desai, Philip J. Rosenthal, 2005, Medicinal Chemistry Research.

A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue

Patrick G. Schupp, J. Derisi, J. Gut, 2017, Nature Communications.

Discovery of highly selective 7-chloroquinoline-thiohydantoins with potent antimalarial activity.

Vipan Kumar, J. Gut, P. Rosenthal, 2014, European journal of medicinal chemistry.

Reaction of 3,5,6-trichloro-1,2,4-triazine with simple nucleophiles

F. Šorm, J. Gut, A. Pískala, 1975 .

CHEMISTRY OF 1,2,4-TRIAZINE PART 8, REACTION OF 3,5,6-TRICHLORO-1,2,4-TRIAZINE WITH SIMPLE NUCLEOPHILES

F. Šorm, J. Gut, A. Pískala, 1975 .

On the chemistry of 1,2,4-triazine I. Synthesis of substituted 1,2,4-triazin-5-ones from α-keto acid amidrazone derivatives

J. Gut, P. Fiedler, V. Uchytilová, 1971 .

Falcipain inhibitors: optimization studies of the 2-pyrimidinecarbonitrile lead series.

Juan Miguel, Jiri Gut, Maria Marco, 2010, Journal of medicinal chemistry.

Nucleic acid components and their analogues. XXV. Note on the preparation of 2,4-dithio-6-azauracil methyl derivatives

J. Gut, M. Prystaš, 1962 .

Hemoglobin Cleavage Site-Specificity of the Plasmodium falciparum Cysteine Proteases Falcipain-2 and Falcipain-3

Markus Hardt, Charles S. Craik, Philip J. Rosenthal, 2009, PloS one.

Antimalarial Benzoxaboroles Target Plasmodium falciparum Leucyl-tRNA Synthetase

J. Derisi, J. Gut, P. Rosenthal, 2016, Antimicrobial Agents and Chemotherapy.

Novel anti-Plasmodial hits identified by virtual screening of the ZINC database

Rui Moreira, Rita C. Guedes, Grace Mugumbate, 2013, Journal of Computer-Aided Molecular Design.

An Endoperoxide‐Based Hybrid Approach to Deliver Falcipain Inhibitors Inside Malaria Parasites

Ana S. Newton, J. Gut, P. Rosenthal, 2013, ChemMedChem.

In Vitro and In Vivo Antimalarial Efficacies of Optimized Tetracyclines

J. Gut, P. Rosenthal, M. Nelson, 2013, Antimicrobial Agents and Chemotherapy.

Compounds from Sorindeia juglandifolia (Anacardiaceae) exhibit potent anti-plasmodial activities in vitro and in vivo

J. Gut, P. Rosenthal, J. Legac, 2012, Malaria Journal.

Synthesis, docking and in vitro antimalarial evaluation of bifunctional hybrids derived from β-lactams and 7-chloroquinoline using click chemistry.

Vipan Kumar, M. P. Mahajan, J. Gut, 2012, Bioorganic & medicinal chemistry letters.

Computer-Aided Drug Design of Falcipain Inhibitors: Virtual Screening, Structure-Activity Relationships, Hydration Site Thermodynamics, and Reactivity Analysis

Woody Sherman, Mitchell A. Avery, Falgun Shah, 2012, J. Chem. Inf. Model..

Antimalarial activity of azadipeptide nitriles.

J. Gut, P. Rosenthal, M. Gütschow, 2010, Bioorganic & medicinal chemistry letters.

Enantiopure Indolizinoindolones with in vitro Activity against Blood‐ and Liver‐Stage Malaria Parasites

Maria M. M. Santos, J. Gut, P. Rosenthal, 2015, ChemMedChem.

Stage Malaria Novel Potent Metallocenes against Liver

J. Gut, R. Moreira, M. Prudêncio, 2012 .

Novel Potent Metallocenes against Liver Stage Malaria

J. Gut, P. Rosenthal, V. do Rosário, 2011, Antimicrobial Agents and Chemotherapy.

Screening of Protease Inhibitors as Antiplasmodial Agents. Part I: Aziridines and Epoxides

J. Gut, M. Leippe, T. Schirmeister, 2007, ChemMedChem.

Cryptosporidium parvum: lectins mediate irreversible inhibition of sporozoite infectivity in vitro.

J. Gut, R. Nelson, 1999, The Journal of eukaryotic microbiology.

5HT1A Serotonin Receptor Agonists Inhibit Plasmodium falciparum by Blocking a Membrane Channel

P. Ruben, J. Gut, P. Rosenthal, 2003, Antimicrobial Agents and Chemotherapy.

Design, synthesis and evaluation of 3-methylene-substituted indolinones as antimalarials.

Maria M. M. Santos, J. Gut, P. Rosenthal, 2011, European journal of medicinal chemistry.

Identification of novel parasitic cysteine protease inhibitors by use of virtual screening. 2. The available chemical directory.

Jiri Gut, Prashant V Desai, Mitchell Avery, 2006, Journal of medicinal chemistry.

Reaction of six-membered cyclic hydrazides with aromatic aldehydes

J. Gut, P. Fiedler, A. Novácek, 1968 .

On the condensation of ethyl cyanoacetate with some cyclic anhydrides and imides

F. Šorm, J. Gut, P. Kaňkovský, 1950 .

Plasmodium falciparum cysteine protease falcipain-1 is not essential in erythrocytic stage malaria parasites.

J. Gut, P. Rosenthal, D. Goldberg, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Cryptosporidium and Toxoplasma Parasites Are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase

J. Gut, P. Rosenthal, A. Bougdour, 2016, Antimicrobial Agents and Chemotherapy.

Cryptosporidium parvum sporozoites deposit trails of 11A5 antigen during gliding locomotion and shed 11A5 antigen during invasion of MDCK cells in vitro.

J. Gut, R. Nelson, 1994, The Journal of eukaryotic microbiology.

Synthesis and structure-activity-relationship studies of thiazolidinediones as antiplasmodial inhibitors of the Plasmodium falciparum cysteine protease falcipain-2.

J. Gut, P. Rosenthal, K. Chibale, 2015, European journal of medicinal chemistry.

Artefenomel Regioisomer RLA-3107 Is a Promising Lead for the Discovery of Next-Generation Endoperoxide Antimalarials.

J. Gut, A. Renslo, Brian R. Blank, 2023, ACS medicinal chemistry letters.

Development of Novel Peptide-Based Michael Acceptors Targeting Rhodesain and Falcipain-2 for the Treatment of Neglected Tropical Diseases (NTDs).

J. Gut, P. Rosenthal, U. Hellmich, 2017, Journal of medicinal chemistry.

Mining a Cathepsin Inhibitor Library for New Antiparasitic Drug Leads

Michelle R. Arkin, Anjan Debnath, Philip J. Rosenthal, 2011, PLoS neglected tropical diseases.

Flavones as isosteres of 4(1H)-quinolones: discovery of ligand efficient and dual stage antimalarial lead compounds.

J. Gut, P. Rosenthal, M. Mota, 2013, European journal of medicinal chemistry.

Quinolin-4(1H)-imines are potent antiplasmodial drugs targeting the liver stage of malaria.

G. Schneider, J. Gut, P. Rosenthal, 2013, Journal of medicinal chemistry.

Novel cinnamic acid/4-aminoquinoline conjugates bearing non-proteinogenic amino acids: towards the development of potential dual action antimalarials.

J. Gut, P. Rosenthal, J. Gomes, 2012, European journal of medicinal chemistry.

Synthesis and Evaluation of Non-peptidic Cysteine Protease Inhibitors of P. falciparum Derived from Etacrynic Acid

J. Gut, P. Rosenthal, M. Leippe, 2008, Molecules.

Potent in Vitro and in Vivo Antimalarials

J. Gut, R. Payne, N. Hunt, 2019 .

Design, Synthesis, and Antiplasmodial Activity of Hybrid Compounds Based on (2R,3S)-N-Benzoyl-3-phenylisoserine.

J. Gut, P. Rosenthal, K. Chibale, 2013, ACS medicinal chemistry letters.

Benzoheterocyclic amodiaquine analogues with potent antiplasmodial activity: synthesis and pharmacological evaluation.

J. Gut, P. Rosenthal, K. Chibale, 2012, Bioorganic & medicinal chemistry letters.

Chloramphenicol analogues I.

F. Šorm, J. Gut, D. Reichl, 1950 .

Synthetic Pathways toward Heterocycle − Cinnamic Acid Conjugates 7 and 9 −

J. Gut, P. Rosenthal, M. Prudêncio, 2013 .

Nucleic acids components and their analogues. XXXV. A contribution to the reaction of ethyl orthoformate with urea

J. Gut, A. Pískala, 1963 .

Antimalarial Effects of Human Immunodeficiency Virus Type 1 Protease Inhibitors Differ from Those of the Aspartic Protease Inhibitor Pepstatin

J. Gut, P. Rosenthal, Jun Liu, 2006, Antimicrobial Agents and Chemotherapy.

Binding Mode and Potency of N-Indolyloxopyridinyl-4-aminopropanyl-Based Inhibitors Targeting Trypanosoma cruzi CYP51

J. Gut, J. McKerrow, M. Cameron, 2014, Journal of Medicinal Chemistry.

Nucleic acids components and their analogues. LXXXVII. The preparation of 1-amino-5,6-dihydrouracil and its derivatives

J. Gut, A. Novácek, 1967 .

Exploring the Molecular Basis of Qo bc1 Complex Inhibitors Activity to Find Novel Antimalarials Hits

Rui Moreira, Jiri Gut, J. Gut, 2013, Molecular informatics.

Extracts from Annona Muricata L. and Annona Reticulata L. (Annonaceae) Potently and Selectively Inhibit

J. Gut, J. Legac, F. Boyom, 2015 .

Michael acceptor based antiplasmodial and antitrypanosomal cysteine protease inhibitors with unusual amino acids.

J. Gut, P. Rosenthal, M. Leippe, 2010, Journal of medicinal chemistry.

Cryptosporidium parvum: in vitro cultivation in Madin-Darby canine kidney cells.

J. Gut, C. Petersen, J. Leech, 1991, The Journal of protozoology.

Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites

J. Gut, P. Rosenthal, D. Wirth, 2016, ChemMedChem.

Imidazolidin-4-one peptidomimetic derivatives of primaquine: synthesis and antimalarial activity.

J. Gut, P. Rosenthal, V. do Rosário, 2008, Bioorganic & medicinal chemistry letters.

A Reprofiled Drug, Auranofin, Is Effective against Metronidazole-Resistant Giardia lamblia

J. Gut, L. Eckmann, J. McKerrow, 2013, Antimicrobial Agents and Chemotherapy.

Development of Novel Peptide-Based Michael Acceptors Targeting Rhodesain and Falcipain-2 for the Treatment of Neglected Tropical Diseases (NTDs).

J. Gut, P. Rosenthal, U. Hellmich, 2017, Journal of medicinal chemistry.

Identification of new antimalarial leads by use of virtual screening against cytochrome bc₁.

J. Gut, P. Rosenthal, R. Guedes, 2011, Bioorganic & medicinal chemistry.

Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds.

J. Gut, P. Rosenthal, K. Chibale, 2010, Bioorganic & medicinal chemistry.

4‐Aminoquinoline‐β‐Lactam Conjugates: Synthesis, Antimalarial, and Antitubercular Evaluation

Vipan Kumar, J. Gut, C. Biot, 2014, Chemical biology & drug design.

Novel thiolactone-isatin hybrids as potential antimalarial and antitubercular agents.

J. Gut, P. Rosenthal, K. Chibale, 2011, Bioorganic & medicinal chemistry letters.