C. Lerner

发表

A Real-World Perspective on Molecular Design.

W. Guba, J. Hert, B. Kuhn, 2016, Journal of medicinal chemistry.

Strukturbasiertes Design, Synthese und in vitro Bewertung von Bisubstrat-Inhibitoren der Catechol-0-Methyltransferase (COMT)

C. Lerner, 2003 .

Synthesis of Novel Nonpeptidic Thrombin Inhibitors

F. Diederich, L. Weber, D. Banner, 2000 .

Synthesis and Biological Evaluation of Potent Bisubstrate Inhibitors of the Enzyme Catechol O‐Methyltransferase (COMT) Lacking a Nitro Group

F. Diederich, C. Lerner, E. Borroni, 2006 .

Bisubstrate Inhibitors of the Enzyme Catechol O‐Methyltransferase (COMT): Efficient Inhibition Despite the Lack of a Nitro Group

F. Diederich, C. Lerner, E. Borroni, 2004, Chembiochem : a European journal of chemical biology.

Molecular recognition at the active site of catechol-O-methyltransferase (COMT): adenine replacements in bisubstrate inhibitors.

F. Diederich, C. Lerner, M. Rudolph, 2011, Chemistry.

Bisubstrate Inhibitors of Catechol O‐Methyltransferase (COMT): the Crucial Role of the Ribose Structural Unit for Inhibitor Binding Affinity

F. Diederich, C. Lerner, W. Schweizer, 2006, ChemMedChem.

Bisubstrate inhibitors for the enzyme catechol-O-methyltransferase (COMT): influence of inhibitor preorganisation and linker length between the two substrate moieties on binding affinity.

F. Diederich, C. Lerner, A. Ruf, 2003, Organic & biomolecular chemistry.

Design of Potent and Druglike Nonphenolic Inhibitors for Catechol O-Methyltransferase Derived from a Fragment Screening Approach Targeting the S-Adenosyl-l-methionine Pocket.

C. Lerner, M. Rudolph, A. Ehler, 2016, Journal of medicinal chemistry.

Bisubstrate Inhibitors for the Enzyme Catechol O-Methyltransferase (COMT): Dramatic Effects of Ribose Modifications on Binding Affinity and Binding Mode

F. Diederich, C. Lerner, V. Gramlich, 2003 .

X-ray Crystal Structure of a Bisubstrate Inhibitor Bound to the Enzyme Catechol-O-methyltransferase: A Dramatic Effect of Inhibitor Preorganization on Binding Affinity.

F. Diederich, C. Lerner, A. Ruf, 2001, Angewandte Chemie.

Semiclassical model of electrically detected magnetic resonance in undoped a-Si:H

C. Lerner, K. Lips, W. Fuhs, 1996 .

Synthesis of Novel Nonpeptidic Thrombin Inhibitors.

F. Diederich, L. Weber, D. Banner, 2000 .

Transport and Recombination Channels in Undoped Microcrystalline Silicon Studied by ESR and EDMR

C. Lerner, K. Lips, W. Fuhs, 1997 .

Structural, electronic and magnetic properties of splat-quenched FeCx alloys (x⩽0.05)

C. Lerner, M. Cadeville, J. Friedt, 1977 .

A Convergent Enantioselective Route to Structurally Diverse 6-Deoxytetracycline Antibiotics

Andrew G Myers, C. Lerner, D. Siegel, 2005, Science.

Catechol-O-methyltransferase in complex with substituted 3'-deoxyribose bisubstrate inhibitors.

F. Diederich, C. Bissantz, C. Lerner, 2012, Acta crystallographica. Section D, Biological crystallography.

On the electronic structure of interstitial transition-metal based alloys with boron and carbon impurities

C. Lerner, M. Cadeville, 1976 .

Evidence for a transition from strong to weak ferromagnetism in Ni-Fe alloys from an investigation on ternary (Ni-Fe)C alloys

C. Lerner, R. Caudron, M. Cadeville, 1974 .

A robust platform for the synthesis of new tetracycline antibiotics.

C. Lerner, D. Siegel, P. Wright, 2008, Journal of the American Chemical Society.

Precision analysis of quantum corrections to the conductivity in disordered conductors

C. Lerner, E. Steep, W. Gey, 1993 .

Electronic structure of interstitial carbon in ferromagnetic transition metals prepared by splat-quenching

C. Lerner, M. Cadeville, J. Friedt, 1977 .

A Novel Endonuclease Inhibitor Exhibits Broad-Spectrum Anti-Influenza Virus Activity In Vitro

C. Lerner, E. Govorkova, Jeremy C. Jones, 2016, Antimicrobial Agents and Chemotherapy.

Molecular recognition at the active site of catechol-o-methyltransferase: energetically favorable replacement of a water molecule imported by a bisubstrate inhibitor.

Edilio Borroni, Christian Lerner, François Diederich, 2009, Angewandte Chemie.

Machine learning-powered antibiotics phenotypic drug discovery

Hoa Hue Truong, C. Lerner, Fethallah Benmansour, 2019, Scientific Reports.

Machine learning-powered antibiotics phenotypic drug discovery

Fethallah Benmansour, Kenneth Bradley, Andreas Maunz, 2019, Scientific Reports.

Safety screening in early drug discovery: An optimized assay panel.

Wolfgang Guba, Christian Kramer, Manfred Kansy, 2019, Journal of pharmacological and toxicological methods.