H. Al‐Hashimi

发表

Discovery of selective bioactive small molecules by targeting an RNA dynamic ensemble.

I. Andricioaei, A. Stelzer, A. Frank, 2011, Nature chemical biology.

Visualizing Transient Low-Populated Structures of RNA

H. Al‐Hashimi, Elizabeth A. Dethoff, Katja Petzold, 2012, Nature.

H. Al‐Hashimi, N. Walter, 2008, Current opinion in structural biology.

Constructing RNA dynamical ensembles by combining MD and motionally decoupled NMR RDCs: new insights into RNA dynamics and adaptive ligand recognition

Aaron T. Frank, Ioan Andricioaei, Hashim M. Al-Hashimi, 2009, Nucleic acids research.

Constructing atomic-resolution RNA structural ensembles using MD and motionally decoupled NMR RDCs.

Ioan Andricioaei, I. Andricioaei, A. Stelzer, 2009, Methods.

DNA mismatches reveal conformational penalties in protein-DNA recognition

R. Gordân, H. Al‐Hashimi, M. Schumacher, 2020, Nature.

Three RNA Microenvironments Detected in Fluxional Gene Delivery Polyplex Nanoassemblies.

H. Al‐Hashimi, M. B. Banaszak Holl, M. Holl, 2016, ACS macro letters.

Visualizing the formation of an RNA folding intermediate through a fast highly modular secondary structure switch

D. Herschlag, H. Al‐Hashimi, R. Russell, 2016, Nature Communications.

Transient Hoogsteen Base Pairs in Canonical Duplex DNA

I. Andricioaei, H. Al‐Hashimi, P. O'Brien, 2011, Nature.

Characterizing the protonation state of cytosine in transient G·C Hoogsteen base pairs in duplex DNA.

C. Brooks, H. Al‐Hashimi, Garrett B. Goh, 2013, Journal of the American Chemical Society.

m1A and m1G Potently Disrupt A-RNA Structure Due to the Intrinsic Instability of Hoogsteen Base Pairs

Gianmarc Grazioli, Ioan Andricioaei, Hashim M. Al-Hashimi, 2016, Nature Structural &Molecular Biology.

Insights into Watson–Crick/Hoogsteen breathing dynamics and damage repair from the solution structure and dynamic ensemble of DNA duplexes containing m1A

H. Al‐Hashimi, Huiqing Zhou, Honglue Shi, 2017, Nucleic acids research.

Modulation of Hoogsteen dynamics on DNA recognition

I. Andricioaei, H. Al‐Hashimi, Yu Xu, 2018, Nature Communications.

Engineering a Therapeutic Lectin by Uncoupling Mitogenicity from Antiviral Activity

Yi Xue, Jeanne A. Stuckey, Charles M. Rice, 2015, Cell.

Protein Structure and Dynamics from Field-Induced Residual Dipolar Couplings

J. Prestegard, M. Andrec, H. Al‐Hashimi, 2002 .

iRED analysis of TAR RNA reveals motional coupling, long-range correlations, and a dynamical hinge.

Ioan Andricioaei, I. Andricioaei, H. Al‐Hashimi, 2007, Biophysical journal.

Thermodynamics of RNA melting, one base pair at a time.

H. Al‐Hashimi, E. Nikolova, Evgenia N Nikolova, 2010, RNA.

Functional complexity and regulation through RNA dynamics

Hashim M. Al-Hashimi, Jeetender Chugh, H. Al‐Hashimi, 2012, Nature.

Advances in the determination of nucleic acid conformational ensembles.

Shan Yang, Loïc Salmon, H. Al‐Hashimi, 2014, Annual review of physical chemistry.

Rapid and accurate determination of atomistic RNA dynamic ensemble models using NMR and structure prediction

D. Case, D. Herschlag, H. Al‐Hashimi, 2020, Nature Communications.

NMR studies of nucleic acid dynamics.

H. Al‐Hashimi, Hashim M Al-Hashimi, 2013, Journal of magnetic resonance.

3D maps of RNA interhelical junctions

C. Brooks, H. Al‐Hashimi, M. H. Bailor, 2011, Nature Protocols.

Characterizing the relative orientation and dynamics of RNA A-form helices using NMR residual dipolar couplings

D. Patel, H. Al‐Hashimi, M. H. Bailor, 2007, Nature Protocols.

Review NMR studies of RNA dynamics and structural plasticity using NMR residual dipolar couplings

Hashim M. Al-Hashimi, Qi Zhang, H. Al‐Hashimi, 2007 .

Variation of molecular alignment as a means of resolving orientational ambiguities in protein structures from dipolar couplings.

J H Prestegard, J. Prestegard, H. Al‐Hashimi, 2000, Journal of magnetic resonance.

Conservation and functional importance of carbon-oxygen hydrogen bonding in AdoMet-dependent methyltransferases.

H. Al‐Hashimi, R. Mehl, S. Scheiner, 2013, Journal of the American Chemical Society.

Secondary structure encodes a cooperative tertiary folding funnel in the Azoarcus ribozyme

C. Brooks, H. Al‐Hashimi, A. M. Mustoe, 2015, Nucleic acids research.

RNA Structural Modules Control the Rate and Pathway of RNA Folding and Assembly.

D. Herschlag, H. Al‐Hashimi, R. Russell, 2016, Journal of molecular biology.

Environmental Effects on Guanine-Thymine Mispair Tautomerization Explored with Quantum Mechanical/Molecular Mechanical Free Energy Simulations.

H. Al‐Hashimi, S. Hammes-Schiffer, A. Rangadurai, 2020, Journal of the American Chemical Society.

Characterizing micro-to-millisecond chemical exchange in nucleic acids using off-resonance R1ρ relaxation dispersion.

H. Al‐Hashimi, Honglue Shi, A. Rangadurai, 2019, Progress in nuclear magnetic resonance spectroscopy.

120 Role of dynamic base pair polymorphism in the central dogma of molecular biology

H. Al‐Hashimi, Huiqing Zhou, Isaac J. Kimsey, 2015, Journal of biomolecular structure & dynamics.

Probing RNA conformational equilibria within the functional cellular context

Laura R. Ganser, B. Cullen, H. Al‐Hashimi, 2019, bioRxiv.

Shan Yang, Hashim M. Al-Hashimi, Loïc Salmon, 2014, Nature Methods.

Increasing the length of poly-pyrimidine bulges broadens RNA conformational ensembles with minimal impact on stacking energetics

D. Herschlag, H. Al‐Hashimi, Honglue Shi, 2018, RNA.

High Performance Virtual Screening by Targeting a High-resolution RNA Dynamic Ensemble

Laura R. Ganser, Aman D. Kansal, Janghyun Lee, 2017, Nature Structural & Molecular Biology.

Modulating RNA Alignment Using Directional Dynamic Kinks: Application in Determining an Atomic-Resolution Ensemble for a Hairpin using NMR Residual Dipolar Couplings.

D. Case, Loïc Salmon, H. Al‐Hashimi, 2015, Journal of the American Chemical Society.

Unveiling Inherent Degeneracies in Determining Population-Weighted Ensembles of Interdomain Orientational Distributions Using NMR Residual Dipolar Couplings: Application to RNA Helix Junction Helix Motifs.

H. Al‐Hashimi, Shan Yang, 2015, The journal of physical chemistry. B.

An RNA dynamic ensemble at atomic resolution

D. Case, D. Herschlag, H. Al‐Hashimi, 2020, bioRxiv.

Impact of static and dynamic A-form heterogeneity on the determination of RNA global structural dynamics using NMR residual dipolar couplings

I. Andricioaei, H. Al‐Hashimi, C. Musselman, 2006, Journal of biomolecular NMR.

Evidence that electrostatic interactions dictate the ligand-induced arrest of RNA global flexibility.

D. Patel, H. Al‐Hashimi, Qi Zhang, 2005, Angewandte Chemie.

Modulating protein structure with fluorous amino acids: increased stability and native-like structure conferred on a 4-helix bundle protein by hexafluoroleucine.

H. Al‐Hashimi, E. Marsh, Kyung-Hoon Lee, 2006, Journal of the American Chemical Society.

Using fluorine nuclear magnetic resonance to probe the interaction of membrane-active peptides with the lipid bilayer.

H. Al‐Hashimi, B. Buer, J. Chugh, 2010, Biochemistry.

Revealing the high propensity of RNAs to non-specifically bind drug-like small molecules

Laura R. Ganser, B. Cullen, H. Al‐Hashimi, 2020, bioRxiv.

Unraveling the structural complexity in a single-stranded RNA tail: implications for efficient ligand binding in the prequeuosine riboswitch

C. Brooks, H. Al‐Hashimi, N. Walter, 2011, Nucleic acids research.

Structural and Functional Characterization of Sulfonium Carbon-Oxygen Hydrogen Bonding in the Deoxyamino Sugar Methyltransferase TylM1.

H. Al‐Hashimi, Mary C. Clay, R. Mehl, 2019, Biochemistry.

Referencing strategy for the direct comparison of nuclear magnetic resonance and molecular dynamics motional parameters in RNA.

I. Andricioaei, H. Al‐Hashimi, C. Musselman, 2010, The journal of physical chemistry. B.

Measuring thermodynamic preferences to form non-native conformations in nucleic acids using ultraviolet melting

H. Al‐Hashimi, Huiqing Zhou, Honglue Shi, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Probing Na(+)-induced changes in the HIV-1 TAR conformational dynamics using NMR residual dipolar couplings: new insights into the role of counterions and electrostatic interactions in adaptive recognition.

H. Al‐Hashimi, Anette Casiano-Negroni, Xiaoyan Sun, 2007, Biochemistry.

Field- and phage-induced dipolar couplings in a homodimeric DNA quadruplex: relative orientation of G.(C-A) triad and G-tetrad motifs and direct determination of C2 symmetry axis orientation.

D. Patel, H. Al‐Hashimi, E. Skripkin, 2001, Journal of the American Chemical Society.

Determining stoichiometry in homomultimeric nucleic acid complexes using magnetic field induced residual dipolar couplings.

D. Patel, H. Al‐Hashimi, A. Majumdar, 2001, Journal of the American Chemical Society.

Using fluorine nuclear magnetic resonance to probe changes in the structure and dynamics of membrane-active peptides interacting with lipid bilayers.

H. Al‐Hashimi, B. Buer, Yuta Suzuki, 2011, Biochemistry.

RBM45 is an m6A-binding protein that affects neuronal differentiation and the splicing of a subset of mRNAs

H. Al‐Hashimi, Kate D. Meyer, C. Holley, 2022, Cell reports.

Probing Watson-Crick and Hoogsteen base pairing in duplex DNA using dynamic nuclear polarization solid-state NMR spectroscopy

C. Jaroniec, H. Al‐Hashimi, Honglue Shi, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Hoogsteen base pairs increase the susceptibility of double-stranded DNA to cytotoxic damage

H. Al‐Hashimi, Honglue Shi, Yu Xu, 2020, The Journal of Biological Chemistry.

Amphipathic small molecules mimic the binding mode and function of endogenous transcription factors.

Chinmay Y. Majmudar, H. Al‐Hashimi, D. Wemmer, 2009, ACS chemical biology.

Characterizing Watson-Crick versus Hoogsteen base-pairing in a DNA-protein complex using NMR and site-specifically 13 C/ 15 N labeled DNA

D. Case, H. Al‐Hashimi, P. Rice, 2021 .

Development and application of aromatic [13C, 1H] SOFAST-HMQC NMR experiment for nucleic acids

Laura R. Ganser, Janghyun Lee, H. Al‐Hashimi, 2014, Journal of Biomolecular NMR.

Shortening the HIV-1 TAR RNA Bulge by a Single Nucleotide Preserves Motional Modes over a Broad Range of Time Scales.

H. Al‐Hashimi, Mary C. Clay, Anisha Shakya, 2016, Biochemistry.

Utility of 1H NMR chemical shifts in determining RNA structure and dynamics.

I. Andricioaei, A. Frank, H. Al‐Hashimi, 2013, The journal of physical chemistry. B.

New insights into the fundamental role of topological constraints as a determinant of two-way junction conformation

C. Brooks, H. Al‐Hashimi, M. H. Bailor, 2011, Nucleic acids research.

Development and application of aromatic [13C, 1H] SOFAST-HMQC NMR experiment for nucleic acids

Laura R. Ganser, Janghyun Lee, H. Al‐Hashimi, 2014, Journal of Biomolecular NMR.

Direct Evidence for Methyl Group Coordination by Carbon-Oxygen Hydrogen Bonds in the Lysine Methyltransferase SET7/9*

H. Al‐Hashimi, R. Trievel, S. Horowitz, 2011, The Journal of Biological Chemistry.

Understanding the characteristics of nonspecific binding of drug-like compounds to canonical stem–loop RNAs and their implications for functional cellular assays

Laura R. Ganser, B. Cullen, H. Al‐Hashimi, 2020, RNA.

Why are Hoogsteen base pairs energetically disfavored in A-RNA compared to B-DNA?

H. Al‐Hashimi, Huiqing Zhou, Honglue Shi, 2018, Nucleic acids research.

Coarse Grained Models Reveal Essential Contributions of Topological Constraints to the Conformational Free Energy of RNA Bulges

Hashim M. Al-Hashimi, Charles L. Brooks, C. Brooks, 2014, The journal of physical chemistry. B.

Probing conformational transitions towards mutagenic Watson–Crick-like G·T mismatches using off-resonance sugar carbon R1ρ relaxation dispersion

H. Al‐Hashimi, Honglue Shi, A. Rangadurai, 2020, Journal of biomolecular NMR.

Direct evidence for (G)O6···H2-N4(C)+ hydrogen bonding in transient G(syn)-C+ and G(syn)-m5C+ Hoogsteen base pairs in duplex DNA from cytosine amino nitrogen off-resonance R1ρ relaxation dispersion measurements.

H. Al‐Hashimi, Honglue Shi, A. Rangadurai, 2019, Journal of magnetic resonance.

Characterizing RNA dynamics at atomic resolution using solution-state NMR spectroscopy

Jeetender Chugh, H. Al‐Hashimi, Jameson R Bothe, 2011, Nature Methods.

Ultrahigh resolution characterization of domain motions and correlations by multialignment and multireference residual dipolar coupling NMR.

Charles K. Fisher, A. Stelzer, H. Al‐Hashimi, 2008, The journal of physical chemistry. B.

Residual dipolar coupling derived orientational constraints on ligand geometry in a 53 kDa protein-ligand complex.

J H Prestegard, J. Prestegard, H. Al‐Hashimi, 1999, Journal of molecular biology.

Structural and dynamic analysis of residual dipolar coupling data for proteins.

J H Prestegard, L. Kay, J. Prestegard, 2001, Journal of the American Chemical Society.

Rapid determination of protein folds using residual dipolar couplings.

J H Prestegard, J. Prestegard, H. Al‐Hashimi, 2000, Journal of molecular biology.

NMR structures of biomolecules using field oriented media and residual dipolar couplings

J H Prestegard, J. Prestegard, H. Al‐Hashimi, 2000, Quarterly Reviews of Biophysics.

Robust IR‐based detection of stable and fractionally populated G‐C+ and A‐T Hoogsteen base pairs in duplex DNA

H. Al‐Hashimi, Huiqing Zhou, Yu Xu, 2017, FEBS letters.

A quantitative model predicts how m6A reshapes the kinetic landscape of nucleic acid hybridization and conformational transitions

D. Case, H. Al‐Hashimi, Honglue Shi, 2020, Nature Communications.

Visualizing transient Watson–Crick-like mispairs in DNA and RNA duplexes

H. Al‐Hashimi, Katja Petzold, Isaac J. Kimsey, 2015, Nature.

Characterizing RNA Excited States Using NMR Relaxation Dispersion.

H. Al‐Hashimi, Yi Xue, Isaac J. Kimsey, 2015, Methods in enzymology.

Rapid assessment of Watson–Crick to Hoogsteen exchange in unlabeled DNA duplexes using high-power SELOPE imino 1H CEST

H. Al‐Hashimi, Honglue Shi, A. Rangadurai, 2021, Magnetic resonance.

Revealing A-T and G-C Hoogsteen base pairs in stressed protein-bound duplex DNA

H. Al‐Hashimi, M. Schumacher, Honglue Shi, 2021, bioRxiv.

delta-Melt: Nucleic acid conformational penalties from melting experiments

H. Al‐Hashimi, Huiqing Zhou, Honglue Shi, 2021 .

Measuring thermodynamic preferences to form non-native conformations in nucleic acids using melting experiments reveals a rich sequence-specific DNA conformational landscape

H. Al‐Hashimi, Huiqing Zhou, Honglue Shi, 2020, bioRxiv.

Atomic structures of excited state A–T Hoogsteen base pairs in duplex DNA by combining NMR relaxation dispersion, mutagenesis, and chemical shift calculations

D. Case, H. Al‐Hashimi, Honglue Shi, 2018, Journal of Biomolecular NMR.

Widespread transient Hoogsteen base pairs in canonical duplex DNA with variable energetics

H. Al‐Hashimi, Heidi Alvey, E. N. Nikolova, 2014, Nature Communications.

Probing sequence-specific DNA flexibility in a-tracts and pyrimidine-purine steps by nuclear magnetic resonance (13)C relaxation and molecular dynamics simulations.

Ioan Andricioaei, I. Andricioaei, H. Al‐Hashimi, 2012, Biochemistry.

Preparation, resonance assignment, and preliminary dynamics characterization of residue specific 13C/15N-labeled elongated DNA for the study of sequence-directed dynamics by NMR

H. Al‐Hashimi, E. N. Nikolova, 2009, Journal of biomolecular NMR.

Flipping of the ribosomal A-site adenines provides a basis for tRNA selection.

C. Brooks, H. Al‐Hashimi, Anette Casiano-Negroni, 2014, Journal of molecular biology.

Increasing occurrences and functional roles for high energy purine-pyrimidine base-pairs in nucleic acids.

H. Al‐Hashimi, Isaac J. Kimsey, 2014, Current opinion in structural biology.

5‐Oxyacetic Acid Modification Destabilizes Double Helical Stem Structures and Favors Anionic Watson–Crick like cmo5U‐G Base Pairs

H. Al‐Hashimi, M. Tollinger, A. Rangadurai, 2018, Chemistry.

NMR chemical exchange measurements reveal that N6-methyladenosine slows RNA annealing.

H. Al‐Hashimi, Honglue Shi, A. Rangadurai, 2019, Journal of the American Chemical Society.

Direct NMR Evidence that Transient Tautomeric and Anionic States in dG·dT Form Watson-Crick-like Base Pairs.

H. Al‐Hashimi, Isaac J. Kimsey, E. S. Szymanski, 2017, Journal of the American Chemical Society.

New insights into Hoogsteen base pairs in DNA duplexes from a structure-based survey

J. Richardson, H. Al‐Hashimi, Huiqing Zhou, 2015, Nucleic acids research.

A historical account of Hoogsteen base-pairs in duplex DNA.

H. Al‐Hashimi, Huiqing Zhou, Isaac J. Kimsey, 2013, Biopolymers.

NMR studies of an immunomodulatory benzodiazepine binding to its molecular target on the mitochondrial F(1)F(0)-ATPase.

A. Stelzer, H. Al‐Hashimi, G. Glick, 2010, Biopolymers.

DNA mismatches reveal conformational penalties in protein–DNA recognition

R. Gordân, H. Al‐Hashimi, M. Schumacher, 2020, Nature.

Evaluating the uncertainty in exchange parameters determined from off-resonance R1ρ relaxation dispersion for systems in fast exchange.

H. Al‐Hashimi, J. Bothe, Zachary W Stein, 2014, Journal of magnetic resonance.

2′-O-Methylation can increase the abundance and lifetime of alternative RNA conformational states

H. Al‐Hashimi, Honglue Shi, A. Rangadurai, 2020, Nucleic acids research.

Infrared spectroscopic observation of a G-C+ Hoogsteen base pair in the DNA:TATA box binding protein complex under solution conditions.

H. Al‐Hashimi, M. Schumacher, R. Salinas, 2019, Angewandte Chemie.

Topology Links RNA Secondary Structure with Global Conformation, Dynamics, and Adaptation

H. Al‐Hashimi, M. H. Bailor, Hashim M Al-Hashimi, 2010, Science.

NMR Studies of Biomolecular Dynamics and Structural Plasticity Using Residual Dipolar Couplings

H. Al‐Hashimi, J. R. Tolman, 2003 .

Dynamic ensemble of HIV-1 RRE stem IIB reveals non-native conformations that disrupt the Rev-binding site

H. Al‐Hashimi, C. Kreutz, R. Plangger, 2018, bioRxiv.

Beyond static structures of RNA by NMR: Folding, refolding, and dynamics at atomic resolution

H. Al‐Hashimi, 2007, Biopolymers.

Dynamics‐Based Amplification of RNA Function and Its Characterization by Using NMR Spectroscopy

H. Al‐Hashimi, 2005, Chembiochem : a European journal of chemical biology.

The roles of structural dynamics in the cellular functions of RNAs

Daniel Herschlag, Laura R. Ganser, Hashim M. Al-Hashimi, 2019, Nature Reviews Molecular Cell Biology.

Structural basis for impaired 5′ processing of a mutant tRNA associated with defects in neuronal homeostasis

S. Ackerman, H. Al‐Hashimi, V. Gopalan, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Dynamic motions of the HIV-1 frameshift site RNA.

S. Butcher, H. Al‐Hashimi, Elizabeth A. Dethoff, 2015, Biophysical journal.

Probing RNA conformational equilibria within the functional cellular context

Laura R. Ganser, B. Cullen, H. Al‐Hashimi, 2019, bioRxiv.

Invisible RNA state dynamically couples distant motifs

Janghyun Lee, Janghyun Lee, H. Al‐Hashimi, 2014, Proceedings of the National Academy of Sciences.

A rare example of lock-and-key RNA recognition.

H. Al‐Hashimi, Elizabeth A. Dethoff, 2010, Journal of molecular biology.

The roles of structural dynamics in the cellular functions of RNAs

Laura R. Ganser, D. Herschlag, H. Al‐Hashimi, 2019, Nature Reviews Molecular Cell Biology.

2’-O-methylation alters the RNA secondary structural ensemble

H. Al‐Hashimi, Honglue Shi, Mary C. Clay, 2020, bioRxiv.

Dynamic Basis for dG•dT misincorporation via tautomerization and ionization

H. Al‐Hashimi, Z. Suo, Anisha Shakya, 2018, Nature.

The RRM of the kRNA-editing protein TbRGG2 uses multiple surfaces to bind and remodel RNA

H. Al‐Hashimi, M. Schumacher, B. Travis, 2018, Nucleic acids research.

Single transcriptional and translational preQ1 riboswitches adopt similar pre-folded ensembles that follow distinct folding pathways into the same ligand-bound structure

J. Wedekind, C. Brooks, H. Al‐Hashimi, 2013, Nucleic acids research.

A general method for constructing atomic-resolution RNA ensembles using NMR residual dipolar couplings: the basis for interhelical motions revealed.

I. Andricioaei, Loïc Salmon, H. Al‐Hashimi, 2013, Journal of the American Chemical Society.

mRNA interactions with disordered regions control protein activity

C. Mayr, H. Al‐Hashimi, A. Mey, 2023, bioRxiv.

Hierarchy of RNA functional dynamics.

C. Brooks, H. Al‐Hashimi, Charles L Brooks, 2014, Annual review of biochemistry.

Demonstration that small molecules can bind and stabilize low-abundance short-lived RNA excited conformational states.

Laura R. Ganser, H. Al‐Hashimi, A. Hargrove, 2019, Journal of molecular biology.

Probing transient Hoogsteen hydrogen bonds in canonical duplex DNA using NMR relaxation dispersion and single-atom substitution.

H. Al‐Hashimi, E. N. Nikolova, Federico L Gottardo, 2012, Journal of the American Chemical Society.

Anomalous reverse transcription through chemical modifications in polyadenosine stretches

Rhiju Das, Wipapat Kladwang, Rhiju Das, 2020, bioRxiv.

Incorporation of CC steps into Z-DNA: interplay between B-Z junction and Z-DNA helical formation.

H. Al‐Hashimi, K. Lowenhaupt, J. Bothe, 2012, Biochemistry.

Hidden Structural Modules in a Cooperative RNA Folding Transition

D. Herschlag, Rhiju Das, H. Al‐Hashimi, 2018, Cell reports.

Pseudouridine and N6-methyladenosine modifications weaken PUF protein/RNA interactions.

D. Herschlag, H. Al‐Hashimi, P. Vaidyanathan, 2017, RNA.

m6A minimally impacts the structure, dynamics, and Rev ARM binding properties of HIV-1 RRE stem IIB

H. Al‐Hashimi, C. Kreutz, R. Plangger, 2019, bioRxiv.

A potentially abundant junctional RNA motif stabilized by m6A and Mg2+

H. Al‐Hashimi, M. Schumacher, Kate D. Meyer, 2018, Nature Communications.

Topological constraints are major determinants of tRNA tertiary structure and dynamics and provide basis for tertiary folding cooperativity

Hashim M. Al-Hashimi, Charles L. Brooks, C. Brooks, 2014, Nucleic acids research.

Inter-helical conformational preferences of HIV-1 TAR-RNA from maximum occurrence analysis of NMR data and molecular dynamics simulations.

Loïc Salmon, H. Al‐Hashimi, C. Luchinat, 2016, Physical chemistry chemical physics : PCCP.

Structural dynamics of a single-stranded RNA–helix junction using NMR

H. Al‐Hashimi, C. D. Eichhorn, 2014, RNA.

Domain-elongation NMR spectroscopy yields new insights into RNA dynamics and adaptive recognition.

H. Al‐Hashimi, Qi Zhang, 2009, RNA.

Characterizing complex dynamics in the transactivation response element apical loop and motional correlations with the bulge by NMR, molecular dynamics, and mutagenesis.

Ioan Andricioaei, I. Andricioaei, H. Al‐Hashimi, 2008, Biophysical journal.

Extending the NMR spatial resolution limit for RNA by motional couplings

H. Al‐Hashimi, Qi Zhang, 2008, Nature Methods.

Resolving fast and slow motions in the internal loop containing stem-loop 1 of HIV-1 that are modulated by Mg2+ binding: role in the kissing–duplex structural transition

H. Al‐Hashimi, Xiaoyan Sun, Qi Zhang, 2007, Nucleic acids research.

Structural plasticity and Mg2+ binding properties of RNase P P4 from combined analysis of NMR residual dipolar couplings and motionally decoupled spin relaxation.

H. Al‐Hashimi, C. Fierke, A. Andrews, 2006, RNA.

Resolving the Motional Modes That Code for RNA Adaptation

Qi Zhang, H. Al‐Hashimi, Hashim M Al-Hashimi, 2006, Science.

Amiloride as a new RNA-binding scaffold with activity against HIV-1 TAR.

Laura R. Ganser, Gary J. Kapral, Janghyun Lee, 2017, MedChemComm.

Structural and Dynamic Basis for Low-Affinity, High-Selectivity Binding of L-Glutamine by the Glutamine Riboswitch.

Yi Xue, A. Serganov, D. Patel, 2015, Cell reports.

Slowdown of Interhelical Motions Induces a Glass Transition in RNA.

I. Andricioaei, A. Frank, H. Al‐Hashimi, 2015, Biophysical journal.

The RRM of the kRNA-editing protein TbRGG2 uses multiple surfaces to bind and remodel RNA.

Schumacher, H. Al‐Hashimi, B. Travis, 2018 .

Influence of dimethylsulfoxide on RNA structure and ligand binding.

Janghyun Lee, H. Al‐Hashimi, Mitchell McBrairty, 2013, Analytical chemistry.

Conformational analysis of a flexible oligosaccharide using residual dipolar couplings.

J H Prestegard, J. Prestegard, H. Al‐Hashimi, 2001, Journal of the American Chemical Society.

Insights into Domain–Domain Motions in Proteins and RNA from Solution NMR

Claudio Luchinat, Giacomo Parigi, Enrico Ravera, 2014, Accounts of chemical research.

Dynamic basis for dA•dGTP and dA•d8OGTP misincorporation via Hoogsteen base pairs

H. Al‐Hashimi, Honglue Shi, A. Rangadurai, 2023, Nature Chemical Biology.

Concerted motions in HIV-1 TAR RNA may allow access to bound state conformations: RNA dynamics from NMR residual dipolar couplings.

D. Patel, H. Al‐Hashimi, Weidong Hu, 2002, Journal of molecular biology.

Extending the Sensitivity of CEST NMR Spectroscopy to Micro‐to‐Millisecond Dynamics in Nucleic Acids Using High‐Power Radio‐Frequency Fields

H. Al‐Hashimi, Honglue Shi, A. Rangadurai, 2020, Angewandte Chemie.

Extending the Sensitivity of CEST to Micro-to-Millisecond Dynamics in Nucleic Acids Using High Power Radio-Frequency Fields.

H. Al‐Hashimi, Honglue Shi, A. Rangadurai, 2020, Angewandte Chemie.

Water-Mediated Carbon-Oxygen Hydrogen Bonding Facilitates S-Adenosylmethionine Recognition in the Reactivation Domain of Cobalamin-Dependent Methionine Synthase.

H. Al‐Hashimi, Mary C. Clay, S. Scheiner, 2018, Biochemistry.

Exciting Structures

H. Al‐Hashimi, 2010, Science.

Probing conformational transitions towards mutagenic Watson–Crick-like G·T mismatches using off-resonance sugar carbon R1ρ relaxation dispersion

H. Al‐Hashimi, Honglue Shi, A. Rangadurai, 2020, Journal of Biomolecular NMR.

Exposing hidden high-affinity RNA conformational states.

T. Oas, H. Al‐Hashimi, N. I. Orlovsky, 2019, Journal of the American Chemical Society.

Visualizing spatially correlated dynamics that directs RNA conformational transitions

Charles K. Fisher, Hashim M. Al-Hashimi, Qi Zhang, 2007, Nature.

Developments in solution-state NMR yield broader and deeper views of the dynamic ensembles of nucleic acids.

H. Al‐Hashimi, Honglue Shi, Bei Liu, 2021, Current opinion in structural biology.

Molecular symmetry as an aid to geometry determination in ligand protein complexes.

J H Prestegard, J. Prestegard, H. Al‐Hashimi, 2000, Journal of magnetic resonance.

Residual dipolar couplings: Synergy between NMR and structural genomics

Hashim M. Al-Hashimi, Dinshaw J. Patel, D. Patel, 2002, Journal of biomolecular NMR.

The Mechanism of HdeA Unfolding and Chaperone Activation.

Logan S. Ahlstrom, E. Eisenmesser, Loïc Salmon, 2018, Journal of molecular biology.

RNA dynamics by design: biasing ensembles towards the ligand-bound state.

A. Stelzer, J. Kratz, H. Al‐Hashimi, 2010, Angewandte Chemie.

Modulation of Hoogsteen dynamics on DNA recognition

I. Andricioaei, H. Al‐Hashimi, Yu Xu, 2018, Nature Communications.

Characterizing Watson-Crick versus Hoogsteen Base Pairing in a DNA-Protein Complex Using Nuclear Magnetic Resonance and Site-Specifically 13C- and 15N-Labeled DNA.

D. Case, H. Al‐Hashimi, P. Rice, 2019, Biochemistry.

Extending the range of microsecond-to-millisecond chemical exchange detected in labeled and unlabeled nucleic acids by selective carbon R(1rho) NMR spectroscopy.

H. Al‐Hashimi, Anette Casiano-Negroni, Alexandar L. Hansen, 2009, Journal of the American Chemical Society.

A potentially abundant junctional RNA motif stabilized by m6A and Mg2+

H. Al‐Hashimi, M. Schumacher, Kate D. Meyer, 2018, Nature Communications.

Manipulating unconventional CH-based hydrogen bonding in a methyltransferase via noncanonical amino acid mutagenesis.

H. Al‐Hashimi, R. Mehl, S. Scheiner, 2014, ACS chemical biology.

Topological constraints: using RNA secondary structure to model 3D conformation, folding pathways, and dynamic adaptation.

C. Brooks, H. Al‐Hashimi, M. H. Bailor, 2011, Current opinion in structural biology.

HIV-1 leader RNA dimeric interface revealed by NMR

Laura R. Ganser, H. Al‐Hashimi, 2016, Proceedings of the National Academy of Sciences.

Rapid Exchange Between Free and Bound States in RNA-Dendrimer Polyplexes: Implications on the Mechanism of Delivery and Release.

H. Al‐Hashimi, M. B. Banaszak Holl, C. Dougherty, 2016, Biomacromolecules.

Resolving sugar puckers in RNA excited states exposes slow modes of repuckering dynamics

Laura R. Ganser, H. Al‐Hashimi, Mary C. Clay, 2017, Nucleic acids research.

Noncanonical secondary structure stabilizes mitochondrial tRNA(Ser(UCN)) by reducing the entropic cost of tertiary folding.

C. Brooks, H. Al‐Hashimi, C. Fierke, 2015, Journal of the American Chemical Society.

Sequence-specific B-DNA flexibility modulates Z-DNA formation.

H. Al‐Hashimi, K. Lowenhaupt, Jameson R Bothe, 2011, Journal of the American Chemical Society.

RNA conformational propensities determine cellular activity

Laura R. Ganser, B. Cullen, D. Herschlag, 2022, bioRxiv.

Probing motions between equivalent RNA domains using magnetic field induced residual dipolar couplings: accounting for correlations between motions and alignment.

Qi Zhang, A. Serganov, H. Al‐Hashimi, 2003, Journal of the American Chemical Society.

Intrinsic dynamics of DNA-polymer complexes: a mechanism for DNA release.

H. Al‐Hashimi, M. B. Banaszak Holl, Lisa E. Prevette, 2012, Molecular pharmaceutics.

Variable helix elongation as a tool to modulate RNA alignment and motional couplings.

H. Al‐Hashimi, Elizabeth A. Dethoff, Alexandar L. Hansen, 2010, Journal of magnetic resonance.

Insight into the CSA tensors of nucleobase carbons in RNA polynucleotides from solution measurements of residual CSA: towards new long-range orientational constraints.

H. Al‐Hashimi, Alexandar L. Hansen, 2006, Journal of magnetic resonance.

Argininamide binding arrests global motions in HIV-1 TAR RNA: comparison with Mg2+-induced conformational stabilization.

A. Serganov, D. Patel, H. Al‐Hashimi, 2004, Journal of molecular biology.

Mg2+-induced variations in the conformation and dynamics of HIV-1 TAR RNA probed using NMR residual dipolar couplings.

D. Patel, H. Al‐Hashimi, A. Majumdar, 2003, Journal of molecular biology.

Towards structural genomics of RNA: rapid NMR resonance assignment and simultaneous RNA tertiary structure determination using residual dipolar couplings.

D. Patel, H. Al‐Hashimi, A. Majumdar, 2002, Journal of molecular biology.

Dynamic ensemble of HIV-1 RRE stem IIB reveals non-native conformations that disrupt the Rev binding site

H. Al‐Hashimi, C. Kreutz, R. Plangger, 2018, bioRxiv.

Water-Mediated Carbon − Oxygen Hydrogen Bonding Facilitates

H. Al‐Hashimi, Mary C. Clay, S. Scheiner, 2018 .

Dynamics of large elongated RNA by NMR carbon relaxation.

H. Al‐Hashimi, Alexandar L. Hansen, 2007, Journal of the American Chemical Society.

RNA structure: Adding a second dimension.

H. Al‐Hashimi, Katja Petzold, 2011, Nature chemistry.

NMR measurements of transient low-populated tautomeric and anionic Watson-Crick-like G·T/U in RNA:DNA hybrids: Implications for the fidelity of transcription and CRISPR/Cas9 gene editing

H. Al‐Hashimi, A. Rangadurai, Or Szekely, 2023, bioRxiv.

Advances in the determination of nucleic acid conformational ensembles.

Loïc Salmon, H. Al‐Hashimi, Shan Yang, 2014, Annual review of physical chemistry.

Influence of dimethylsulfoxide on RNA structure and ligand binding.

Janghyun Lee, H. Al‐Hashimi, Mitchell McBrairty, 2013, Analytical chemistry.

Intrinsic dynamics of DNA-polymer complexes: a mechanism for DNA release.

H. Al‐Hashimi, Lisa E. Prevette, E. N. Nikolova, 2012, Molecular pharmaceutics.

Characterizing RNA Excited States Using NMR Relaxation Dispersion.

H. Al‐Hashimi, Yi Xue, Isaac J. Kimsey, 2015, Methods in enzymology.

RNA conformational propensities determine cellular activity

Laura R. Ganser, B. Cullen, D. Herschlag, 2023, Nature.

Referencing strategy for the direct comparison of nuclear magnetic resonance and molecular dynamics motional parameters in RNA.

I. Andricioaei, H. Al‐Hashimi, C. Musselman, 2010, The journal of physical chemistry. B.

Topology Links RNA Secondary Structure with Global Conformation, Dynamics, and Adaptation

H. Al‐Hashimi, M. H. Bailor, Xiaoyan Sun, 2010, Science.

NMR studies of RNA dynamics and structural plasticity using NMR residual dipolar couplings.

Qi Zhang, H. Al‐Hashimi, Anette Casiano-Negroni, 2007, Biopolymers.

Biological Magnetic Resonance

L. Berliner, Praveen B. Srinivas, H. Al‐Hashimi, 2002, Biological Magnetic Resonance.