C. Smolke

发表

Higher-Order Cellular Information Processing with Synthetic RNA Devices

M. Win, C. Smolke, 2008, Science.

Engineering biological systems with synthetic RNA molecules.

Joe C. Liang, C. Smolke, R. Bloom, 2011, Molecular cell.

Programmable ligand-controlled riboregulators of eukaryotic gene expression

Travis S. Bayer, C. Smolke, 2005, Nature Biotechnology.

Model-guided design of ligand-regulated RNAi for programmable control of gene expression

Chase L. Beisel, Travis S. Bayer, C. Smolke, 2008, Molecular systems biology.

A modular and extensible RNA-based gene-regulatory platform for engineering cellular function

M. Win, C. Smolke, 2007, Proceedings of the National Academy of Sciences.

Realizing the potential of synthetic biology

Christopher A. Voigt, G. Church, R. Weiss, 2014, Nature Reviews Molecular Cell Biology.

High-Throughput, Data-Rich Cellular RNA Device Engineering

Christina D Smolke, Brent Townshend, C. Smolke, 2015, Nature Methods.

Synthetic control of a fitness tradeoff in yeast nitrogen metabolism

Chase L. Beisel, Chase L Beisel, Christina D Smolke, 2009, Journal of biological engineering.

The Regulatory Roles of the Galactose Permease and Kinase in the Induction Response of the GAL Network in Saccharomyces cerevisiae*

Kristy M. Hawkins, C. Smolke, 2006, Journal of Biological Chemistry.

Complete biosynthesis of opioids in yeast

C. Smolke, S. Galanie, Kate Thodey, 2015, Science.

The Metabolic Pathway Engineering Handbook : Fundamentals

C. Smolke, 2009 .

Advancing secondary metabolite biosynthesis in yeast with synthetic biology tools.

C. Smolke, Kate Thodey, Isis J Trenchard, 2012, FEMS yeast research.

Production of benzylisoquinoline alkaloids in Saccharomyces cerevisiae.

Kristy M. Hawkins, C. Smolke, 2008, Nature chemical biology.

A microbial biomanufacturing platform for natural and semi-synthetic opiates

C. Smolke, S. Galanie, Kate Thodey, 2014, Nature chemical biology.

De novo production of the key branch point benzylisoquinoline alkaloid reticuline in yeast.

C. Smolke, Kate Thodey, Isis J Trenchard, 2015, Metabolic engineering.

Engineering strategies for the fermentative production of plant alkaloids in yeast.

C. Smolke, Isis J Trenchard, 2015, Metabolic engineering.

Optimization of yeast-based production of medicinal protoberberine alkaloids

C. Smolke, S. Galanie, 2015, Microbial Cell Factories.

Engineering biosynthesis of the anticancer alkaloid noscapine in yeast

Yanran Li, C. Smolke, 2016, Nature Communications.

Complete biosynthesis of noscapine and halogenated alkaloids in yeast

Yanran Li, C. Smolke, Aaron Cravens, 2018, Proceedings of the National Academy of Sciences.

Engineering a microbial biosynthesis platform for de novo production of tropane alkaloids

C. Smolke, P. Srinivasan, 2019, Nature Communications.

Engineering cellular metabolite transport for biosynthesis of computationally predicted tropane alkaloid derivatives in yeast

C. Smolke, P. Srinivasan, 2021, Proceedings of the National Academy of Sciences.

Biosynthesis of medicinal tropane alkaloids in yeast

C. Smolke, P. Srinivasan, 2020, Nature.

Strategies for microbial synthesis of high-value phytochemicals

Yanran Li, C. Smolke, Sijin Li, 2018, Nature Chemistry.

Combinatorial engineering of intergenic regions in operons tunes expression of multiple genes

Brian F. Pfleger, J. Keasling, D. Pitera, 2006, Nature Biotechnology.

Model-driven generation of artificial yeast promoters

Benjamin J. Kotopka, C. Smolke, 2019, Nature Communications.

Codeine-binding RNA aptamers and rapid determination of their binding constants using a direct coupling surface plasmon resonance assay

M. Win, C. Smolke, Joshua S. Klein, 2006, Nucleic acids research.

Synthetic biology: emerging methodologies to catalyze the metabolic engineering design cycle.

Keith E. J. Tyo, C. Smolke, 2012, Metabolic engineering.

High-throughput enzyme evolution in Saccharomyces cerevisiae using a synthetic RNA switch.

Joshua K. Michener, Christina D Smolke, C. Smolke, 2012, Metabolic engineering.

A synthetic library of RNA control modules for predictable tuning of gene expression in yeast

Christina D Smolke, C. Smolke, A. Babiskin, 2011, Molecular systems biology.

Molecular tools for chemical biotechnology.

Christina D Smolke, C. Smolke, S. Galanie, 2013, Current opinion in biotechnology.

Applications of genetically-encoded biosensors for the construction and control of biosynthetic pathways.

Kate Thodey, Joe C. Liang, Joshua K. Michener, 2012, Metabolic engineering.

Synthetic biology: advancing biological frontiers by building synthetic systems

Christina D Smolke, Kate E Galloway, C. Smolke, 2012, Genome Biology.

Galloway Genetic Controllers Dynamically Reshaping Signaling Networks to Program Cell Fate via

C. Smolke, E. Franco, Kate E. Galloway, 2013 .

Dynamically Reshaping Signaling Networks to Program Cell Fate via Genetic Controllers

Elisa Franco, Christina D Smolke, Kate E Galloway, 2013, Science.

Engineering life: building a fab for biology.

Ron Weiss, Drew Endy, Christina Smolke, 2006, Scientific American.

Controlling the metabolic flux through the carotenoid pathway using directed mRNA processing and stabilization.

J. Keasling, V. Martin, C. Smolke, 2001, Metabolic engineering.

Frameworks for programming biological function through RNA parts and devices.

Maung Nyan Win, Joe C. Liang, Christina D Smolke, 2009, Chemistry & biology.

The Metabolic Pathway Engineering Handbook : Tools and Applications

Christina Smolke, C. Smolke, 2009 .

RNA as a Versatile and Powerful Platform for Engineering Genetic Regulatory Tools

Maung Nyan Win, Christina D Smolke, M. Win, 2007, Biotechnology & genetic engineering reviews.

Effect of gene location, mRNA secondary structures, and RNase sites on expression of two genes in an engineered operon.

Jay D Keasling, Christina D Smolke, J. Keasling, 2002, Biotechnology and bioengineering.

Coordinated, Differential Expression of Two Genes through Directed mRNA Cleavage and Stabilization by Secondary Structures

Christina D. Smolke, J. Keasling, C. Smolke, 2000, Applied and Environmental Microbiology.

Synthetic RNA switches as a tool for temporal and spatial control over gene expression.

Christina D Smolke, C. Smolke, Andrew L. Chang, 2012, Current opinion in biotechnology.

Regulation of T cell proliferation with drug-responsive microRNA switches

Christina D Smolke, Yvonne Y Chen, C. Smolke, 2017, Nucleic acids research.

Opportunities in the design and application of RNA for gene expression control

Christina D. Smolke, Maureen McKeague, C. Smolke, 2016, Nucleic acids research.

Kinetic and Equilibrium Binding Characterization of Aptamers to Small Molecules using a Label-Free, Sensitive, and Scalable Platform

Joe C. Liang, Christina D. Smolke, Maureen McKeague, 2014, Analytical chemistry.

Facile characterization of aptamer kinetic and equilibrium binding properties using surface plasmon resonance.

C. Smolke, M. McKeague, Andrew L. Chang, 2014, Methods in enzymology.

A yeast‐based rapid prototype platform for gene control elements in mammalian cells

Christina D Smolke, Kathy Y Wei, C. Smolke, 2013, Biotechnology and bioengineering.

Genetic control of mammalian T-cell proliferation with synthetic RNA regulatory systems

Christina D Smolke, Yvonne Y Chen, C. Smolke, 2010, Proceedings of the National Academy of Sciences.

Reprogramming Cellular Behavior with RNA Controllers Responsive to Endogenous Proteins

Christina D Smolke, Stephanie J. Culler, C. Smolke, 2010, Science.

Design of small molecule-responsive microRNAs based on structural requirements for Drosha processing

Chase L. Beisel, Christina D. Smolke, Stephanie J. Culler, 2010, Nucleic acids research.

Discovery of a previously unknown biosynthetic capacity of naringenin chalcone synthase by heterologous expression of a tomato gene cluster in yeast

C. Smolke, Sijin Li, Deze Kong, 2020, Science Advances.

Construction of ligand-responsive microRNAs that operate through inhibition of Drosha processing.

C. Smolke, R. Bloom, C. Beisel, 2014, Methods in molecular biology.

A versatile cis-blocking and trans-activation strategy for ribozyme characterization

Joe C. Liang, C. Smolke, Andrew B. Kennedy, 2012, Nucleic acids research.

Structure-Guided Engineering of a Scoulerine 9-O-Methyltransferase Enables the Biosynthesis of Tetrahydropalmatrubine and Tetrahydropalmatine in Yeast

C. Smolke, T. R. Valentic, J. Payne, 2020 .

Fluorescence Detection of a Protein‐Bound 2Fe2S Cluster

J. Silberg, C. Smolke, K. Hoff, 2009, Chembiochem : a European journal of chemical biology.

Terminal Developments in Ediacaran Embryology

C. Smolke, 2011, Science.

Complete biosynthesis of the bisbenzylisoquinoline alkaloids guattegaumerine and berbamunine in yeast

C. Smolke, T. R. Valentic, J. Payne, 2021, Proceedings of the National Academy of Sciences.

Informing Biological Design by Integration of Systems and Synthetic Biology

Pamela A. Silver, Christina D. Smolke, P. Silver, 2011, Cell.

Synthetic biology strategies for microbial biosynthesis of plant natural products

Christina D. Smolke, Aaron Cravens, James Payne, 2019, Nature Communications.

Synthetic biology strategies toward heterologous phytochemical production.

Benjamin J. Kotopka, Yanran Li, C. Smolke, 2018, Natural product reports.

Anti-CRISPR-mediated control of gene editing and synthetic circuits in eukaryotic cells

Antonia A. Dominguez, Lei S. Qi, C. Smolke, 2019, Nature Communications.

Synthetic biology strategies for microbial biosynthesis of plant natural products

C. Smolke, Aaron Cravens, J. Payne, 2019, Nature Communications.

From DNA to Targeted Therapeutics: Bringing Synthetic Biology to the Clinic

Christina D Smolke, C. Smolke, Yvonne Y. Chen, 2011, Science Translational Medicine.

Biosynthesis of tetrahydropapaverine and semisynthesis of papaverine in yeast

C. Smolke, Aaron Cravens, Colin Y. Kim, 2022, Proceedings of the National Academy of Sciences of the United States of America.

A computational workflow for the expansion of heterologous biosynthetic pathways to natural product derivatives

V. Hatzimanikatis, C. Smolke, Jasmin Hafner, 2021, Nature communications.

Massively parallel RNA device engineering in mammalian cells with RNA-Seq

Peter H. Dykstra, Christina D. Smolke, Maureen McKeague, 2019, Nature Communications.

Identification and treatment of heme depletion attributed to overexpression of a lineage of evolved P450 monooxygenases

Jens Nielsen, Christina D. Smolke, Joshua K. Michener, 2012, Proceedings of the National Academy of Sciences.

Programmable mutually exclusive alternative splicing for generating RNA and protein diversity

Christina D. Smolke, Sarah A. Munro, Melina Mathur, 2019, Nature Communications.

Building outside of the box: iGEM and the BioBricks Foundation

Christina D Smolke, C. Smolke, 2009, Nature Biotechnology.

Engineering synthetic RNA devices for cell control

C. Smolke, Matias Kaplan, Peter B Dykstra, 2022, Nature Reviews Genetics.

Engineering synthetic RNA devices for cell control

C. Smolke, Matias Kaplan, Peter B Dykstra, 2022, Nature Reviews Genetics.

Mammalian synthetic biology for studying the cell

C. Smolke, Joy S. Xiang, Melina Mathur, 2017, The Journal of cell biology.

Engineering dynamic cell cycle control with synthetic small molecule-responsive RNA devices

C. Smolke, K. Wei, 2015, Journal of biological engineering.

Synthetic biology: advancing the design of diverse genetic systems.

Yen-Hsiang Wang, Christina D Smolke, Kathy Y Wei, 2013, Annual review of chemical and biomolecular engineering.

Functional selection and systematic analysis of intronic splicing elements identify active sequence motifs and associated splicing factors

Stephanie J. Culler, C. Smolke, K. Hoff, 2010, Nucleic acids research.

Highly multiplexed selection of RNA aptamers against a small molecule library

C. Smolke, B. Townshend, Matias Kaplan, 2022, bioRxiv.

A system for multilocus chromosomal integration and transformation-free selection marker rescue.

C. Smolke, M. S. Siddiqui, Atri Choksi, 2014, FEMS yeast research.

A multiplexed, automated evolution pipeline enables scalable discovery and characterization of biosensors

Christina Smolke, Eric J. Hayden, Joy Xiang, 2020, Nature Communications.

Engineering a microbial platform for de novo biosynthesis of diverse methylxanthines.

M. Win, C. Smolke, Aaron Cravens, 2016, Metabolic engineering.

Design Principles for Riboswitch Function

Chase L. Beisel, Christina D. Smolke, C. Smolke, 2009, PLoS Comput. Biol..

A novel bivalent chromatin associates with rapid induction of camalexin biosynthesis genes in response to a pathogen signal in Arabidopsis

S. Rhee, C. Smolke, Deze Kong, 2021, eLife.

Polymerase-guided base editing enables in vivo mutagenesis and rapid protein engineering

C. Smolke, Aaron Cravens, Deze Kong, 2021, Nature Communications.

Design and Construction of Generalizable RNA-Protein Hybrid Controllers by Level-Matched Genetic Signal Amplification.

Christina D. Smolke, Maureen McKeague, Yen-Hsiang Wang, 2016, Cell systems.

Protein-responsive ribozyme switches in eukaryotic cells

Christina D. Smolke, C. Smolke, Andrew B. Kennedy, 2014, Nucleic acids research.

Frameworks for Programming RNA Devices

Maung Nyan Win, Joe C. Liang, Christina D. Smolke, 2010 .

Effect of copy number and mRNA processing and stabilization on transcript and protein levels from an engineered dual-gene operon.

Jay D Keasling, Christina D Smolke, J. Keasling, 2002, Biotechnology and bioengineering.

Biosynthesis of medicinal tropane alkaloids in yeast

C. Smolke, P. Srinivasan, 2020, Nature.

A Novel Chromatin-Opening Element for Stable Long-term Transgene Expression

Shireen S. Rudina, C. Smolke, 2019, bioRxiv.

Production of the cyanogenic glycoside dhurrin in yeast

Benjamin J. Kotopka, C. Smolke, 2019, Metabolic engineering communications.

In Vitro Screening and in Silico Modeling of RNA-Based Gene Expression Control.

C. Smolke, M. McKeague, Yen-Hsiang Wang, 2015, ACS chemical biology.

Effects of transcription induction homogeneity and transcript stability on expression of two genes in a constructed operon

J. Keasling, C. Smolke, A. Khlebnikov, 2001, Applied Microbiology and Biotechnology.

The metabolic pathway engineering handbook

Christina D. Smolke, C. Smolke, 2010 .

Biomedical Applications of RNA-Based Devices.

Christina D. Smolke, Cameron M. Kim, C. Smolke, 2017, Current opinion in biomedical engineering.

Elucidation of tropane alkaloid biosynthesis in Erythroxylum coca using a microbial pathway discovery platform

C. Smolke, J. D’Auria, L. Meinhardt, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Modulating myoblast differentiation with RNA-based controllers

C. Smolke, T. Rando, Peter B Dykstra, 2022, PloS one.

RNA Switches for Synthetic Biology.

Christina D Smolke, Calvin M Schmidt, C. Smolke, 2019, Cold Spring Harbor perspectives in biology.

Synthetic feedback control using an RNAi-based gene-regulatory device

Ryan J Bloom, Sally M Winkler, Christina D Smolke, 2015, Journal of Biological Engineering.

Molecular Switches for Cellular Sensors

Christina Smolke, C. Smolke, 2005 .

Anti-CRISPR-mediated control of gene editing and synthetic circuits in eukaryotic cells

Antonia A. Dominguez, Lei S. Qi, C. Smolke, 2019, Nature Communications.

Science Magazine

C. Smolke, 2011 .

A high-throughput, quantitative cell-based screen for efficient tailoring of RNA device activity

Joe C. Liang, Christina D. Smolke, C. Smolke, 2012, Nucleic acids research.

Fields to fermentors: Brewing botanical chemotherapeutic precursors using genetically engineered yeast.

C. Smolke, P. Srinivasan, 2022, i Medicina.

In vivo fluorescent detection of Fe-S clusters coordinated by human GRX2.

Stephanie J. Culler, J. Silberg, C. Smolke, 2009, Chemistry & biology.

Programmable mutually exclusive alternative splicing for generating RNA and protein diversity

Cameron M. Kim, Shireen S. Rudina, Eric M. Sawyer, 2019, Nature Communications.

A quantitative framework for the forward design of synthetic miRNA circuits

Ryan J Bloom, Sally M Winkler, Christina D Smolke, 2014, Nature Methods.

A convolutional neural network for the prediction and forward design of ribozyme-based gene-control elements

Calvin M Schmidt, C. Smolke, 2021, eLife.

Engineering dynamic cell cycle control with synthetic small molecule-responsive RNA devices

C. Smolke, K. Wei, 2015, Journal of Biological Engineering.

Engineering ligand-responsive RNA controllers in yeast through the assembly of RNase III tuning modules

Christina D. Smolke, C. Smolke, A. Babiskin, 2011, Nucleic acids research.

Control of alphavirus-based gene expression using engineered riboswitches.

C. Smolke, P. Mason, C. Beard, 2015, Virology.

A Bivalent Chromatin Controls Timing of Expression of Camalexin Biosynthesis Genes in Response to a Pathogen Signal in Arabidopsis

S. Rhee, C. Smolke, Deze Kong, 2021, bioRxiv.

Synthetic feedback control using an RNAi-based gene-regulatory device

Sally M Winkler, C. Smolke, R. Bloom, 2015, Journal of biological engineering.

Engineering biological systems with synthetic RNA molecules.

Joe C. Liang, C. Smolke, R. Bloom, 2011, Molecular cell.

High-Throughput, Data-Rich Cellular RNA Device Engineering

C. Smolke, Joy S. Xiang, A. B. Kennedy, 2016 .

Engineering a microbial platform for de novo biosynthesis of diverse methylxanthines.

M. Win, C. Smolke, Aaron Cravens, 2016, Metabolic engineering.

Synthetic RNA modules for fine-tuning gene expression levels in yeast by modulating RNase III activity

Christina D. Smolke, C. Smolke, A. Babiskin, 2011, Nucleic acids research.

Realizing the potential of synthetic biology

Christopher A. Voigt, G. Church, M. Elowitz, 2014, Nature Reviews Molecular Cell Biology.

Bringing It Together with RNA

C. Smolke, Kate Thodey, 2011, Science.

It's the DNA That Counts

C. Smolke, 2009, Science.