M. Disney

发表

Incorporating chemical modification constraints into a dynamic programming algorithm for prediction of RNA secondary structure.

D. Turner, D. Mathews, M. Zuker, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Using Genome Sequence to Enable the Design of Medicines and Chemical Probes.

Jonathan L Chen, Jessica L. Childs-Disney, M. Disney, 2018, Chemical reviews.

The use of carbohydrate microarrays to study carbohydrate-cell interactions and to detect pathogens.

M. Disney, P. Seeberger, 2004, Chemistry & biology.

Detection of bacteria with carbohydrate-functionalized fluorescent polymers.

Matthew D Disney, Peter H Seeberger, M. Disney, 2004, Journal of the American Chemical Society.

Design of a bioactive small molecule that targets the myotonic dystrophy type 1 RNA via an RNA motif-ligand database and chemical similarity searching.

Eric T. Wang, Matthew D Disney, David Housman, 2012, Journal of the American Chemical Society.

RNA Structures as Mediators of Neurological Diseases and as Drug Targets

Viachaslau Bernat, Matthew D. Disney, M. Disney, 2015, Neuron.

Methods to enable the design of bioactive small molecules targeting RNA.

Jessica L. Childs-Disney, Ilyas Yildirim, M. Disney, 2014, Organic & biomolecular chemistry.

A Toxic RNA Templates the Synthesis of Its Own Fluorogenic Inhibitor by Using a Bio-orthogonal Tetrazine Ligation in Cells and Tissues.

M. Disney, Alicia J. Angelbello, 2020, ACS chemical biology.

Precise small-molecule recognition of a toxic CUG RNA repeat expansion.

M. Disney, R. Yasuda, D. Furling, 2017, Nature chemical biology.

Development of pharmacophore models for small molecules targeting RNA: Application to the RNA repeat expansion in myotonic dystrophy type 1.

M. Disney, Alicia J. Angelbello, Suzanne G. Rzuczek, 2016, Bioorganic & medicinal chemistry letters.

Studying a Drug-like, RNA-Focused Small Molecule Library Identifies Compounds That Inhibit RNA Toxicity in Myotonic Dystrophy.

M. Disney, M. Southern, Suzanne G. Rzuczek, 2015, ACS chemical biology.

Small Molecule Inhibition of miR-544 Biogenesis Disrupts Adaptive Responses to Hypoxia by Modulating ATM-mTOR Signaling.

Matthew D Disney, Donald G Phinney, M. Disney, 2015, ACS chemical biology.

Recent advances in developing small molecules targeting RNA.

M. Disney, L. Guan, 2012, ACS chemical biology.

Characterizing RNA– Ligand Interactions Using Two- Dimensional Combinatorial Screening

M. Disney, S. P. Velagapudi, 2011 .

Report of the National Institutes of Health SARS-CoV-2 Antiviral Therapeutics Summit

Mindy I. Davis, D. Baker, D. Hazuda, 2021, The Journal of infectious diseases.

Targeting the r(CGG) Repeats That Cause FXTAS with Modularly Assembled Small Molecules and Oligonucleotides

Jessica L. Childs-Disney, M. Disney, T. Tran, 2014, ACS chemical biology.

The RNA encoding the microtubule-associated protein tau has extensive structure that affects its biology

Jonathan L Chen, Jessica L. Childs-Disney, M. Disney, 2019, PloS one.

Approved Anti-cancer Drugs Target Oncogenic Non-coding RNAs.

Hafeez S Haniff, Jessica L. Childs-Disney, M. Disney, 2018, Cell chemical biology.

Chemical correction of pre-mRNA splicing defects associated with sequestration of muscleblind-like 1 protein by expanded r(CAG)-containing transcripts.

Matthew D Disney, Raman Parkesh, Krzysztof Sobczak, 2012, ACS chemical biology.

A Massively Parallel Selection of Small Molecule-RNA Motif Binding Partners Informs Design of an Antiviral from Sequence.

Hafeez S Haniff, Jessica L. Childs-Disney, M. Disney, 2018, Chem.

Bottom‐up Design of Small Molecules that Stimulate Exon 10 Skipping in Mutant MAPT Pre‐mRNA

M. Disney, Yiling Luo, 2014, Chembiochem : a European journal of chemical biology.

Hoechst 33258 Selectively Inhibits Group I Intron Self‐Splicing by Affecting RNA Folding

D. Turner, M. Disney, Jessica L Childs, 2004, Chembiochem : a European journal of chemical biology.

Methods to identify and optimize small molecules interacting with RNA (SMIRNAS).

M. Disney, Simon Vezina-Dawod, Andrei Ursu, 2019, Drug discovery today.

Structure-activity relationships through sequencing (StARTS) defines optimal and suboptimal RNA motif targets for small molecules.

Steven J. Seedhouse, M. Disney, S. P. Velagapudi, 2010, Angewandte Chemie.

The Privileged Chemical Space Predictor (PCSP): a computer program that identifies privileged chemical space from screens of modularly assembled chemical libraries.

Steven J. Seedhouse, M. Disney, Lucas P Labuda, 2010, Bioorganic & medicinal chemistry letters.

Controlled dehydration improves the diffraction quality of two RNA crystals

M. Disney, Hajeung Park, J. Lee, 2016, BMC Structural Biology.

Targeting RNA with Small Molecules To Capture Opportunities at the Intersection of Chemistry, Biology, and Medicine.

M. Disney, 2019, Journal of the American Chemical Society.

Rational design of chemical genetic probes of RNA function and lead therapeutics targeting repeating transcripts.

M. Disney, 2013, Drug discovery today.

Two-dimensional combinatorial screening of a bacterial rRNA A-site-like motif library: defining privileged asymmetric internal loops that bind aminoglycosides.

M. Disney, T. Tran, 2010, Biochemistry.

Carbohydrate arrays as tools for the glycomics revolution

M. Disney, P. Seeberger, 2004, Drug Discovery Today: TARGETS.

Rapid Generation of miRNA Inhibitor Leads by Bioinformatics and Efficient High-Throughput Screening Methods.

Jessica L. Childs-Disney, M. Disney, D. Phinney, 2017, Methods in molecular biology.

Contributions of individual nucleotides to tertiary binding of substrate by a Pneumocystis carinii group I intron.

D. Turner, M. Disney, S. Gryaznov, 2000, Biochemistry.

Tools for Glycomics: Mapping Interactions of Carbohydrates in Biological Systems

M. Disney, P. Seeberger, D. Ratner, 2004, Chembiochem : a European journal of chemical biology.

Aminoglycoside microarrays to study antibiotic resistance.

M. Disney, J. Blanchard, P. Seeberger, 2004, Angewandte Chemie.

RNA structural analysis of the MYC mRNA reveals conserved motifs that affect gene expression

Jonathan L Chen, Walter N. Moss, Jessica L. Childs-Disney, 2019, PloS one.

Scans of the MYC mRNA reveal multiple stable secondary structures—including a 3′ UTR motif, conserved across vertebrates, that can affect gene expression

Jonathan L Chen, Jessica L. Childs-Disney, Collin A O'Leary, 2019, bioRxiv.

Selective Small Molecule Recognition of RNA Base Pairs.

Hafeez S Haniff, M. Disney, Amanda M. Graves, 2018, ACS combinatorial science.

Structure and Dynamics of RNA Repeat Expansions That Cause Huntington's Disease and Myotonic Dystrophy Type 1.

Jonathan L Chen, Ilyas Yildirim, M. Disney, 2017, Biochemistry.

Drugging the RNAWorld

Jessica L. Childs-Disney, M. Disney, Brendan G. Dwyer, 2018 .

Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing.

Jonathan L Chen, Jessica L. Childs-Disney, G. Rumbaugh, 2020, Journal of the American Chemical Society.

A cross-linking approach to map small molecule-RNA binding sites in cells.

M. Disney, S. P. Velagapudi, Yue Li, 2019, Bioorganic & medicinal chemistry letters.

Transcriptome-Wide Mapping of Small-Molecule RNA-Binding Sites in Cells Informs an Isoform-Specific Degrader of QSOX1 mRNA.

Jessica L. Childs-Disney, M. Disney, A. Adibekian, 2022, Journal of the American Chemical Society.

Targeted small molecule degradation of a hypoxia-associated non-coding RNA enhances the selectivity of an RNA targeted small molecule

M. Disney, Matthew G. Costales, B. Suresh, 2019 .

Targeting RNA structures with small molecules

Jessica L. Childs-Disney, M. Disney, R. Batey, 2022, Nature Reviews Drug Discovery.

"Supra"molecular recognition of Galectin 1.

Jessica L. Childs-Disney, M. Disney, 2007, Chemistry & biology.

Induction and Reversal of Myotonic Dystrophy Type 1 Pre-mRNA Splicing Defects by Small Molecules

Juan J. Marugan, Noel Southall, Wei Zheng, 2013, Nature Communications.

NMR spectroscopy and molecular dynamics simulation of r(CCGCUGCGG)₂ reveal a dynamic UU internal loop found in myotonic dystrophy type 1.

M. Disney, R. Parkesh, M. Fountain, 2011, Biochemistry.

Structure of the myotonic dystrophy type 2 RNA and designed small molecules that reduce toxicity.

George C Schatz, Matthew D Disney, HaJeung Park, 2014, ACS chemical biology.

A toxic RNA catalyzes the in cellulo synthesis of its own inhibitor.

M. Disney, Hajeung Park, Suzanne G. Rzuczek, 2014, Angewandte Chemie.

A dynamic structural model of expanded RNA CAG repeats: a refined X-ray structure and computational investigations using molecular dynamics and umbrella sampling simulations.

George C Schatz, Matthew D Disney, HaJeung Park, 2013, Journal of the American Chemical Society.

Activity of Hoechst 33258 against Pneumocystis carinii f. sp. muris, Candida albicans, and Candida dubliniensis

D. Turner, M. Disney, C. Haidaris, 2005, Antimicrobial Agents and Chemotherapy.

Hexanucleotide Repeat Expansions in c9FTD/ALS and SCA36 Confer Selective Patterns of Neurodegeneration In Vivo.

L. Petrucelli, D. Dickson, M. Disney, 2020, Cell reports.

Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathy

L. Petrucelli, D. Dickson, M. Disney, 2019, Molecular Neurodegeneration.

Small molecule 1a reduces FMRpolyG-mediated toxicity in in vitro and in vivo models for FMR1 premutation

M. Disney, R. Willemsen, M. Cameron, 2021, Human molecular genetics.

Small Molecule Recognition and Tools to Study Modulation of r(CGG)(exp) in Fragile X-Associated Tremor Ataxia Syndrome.

M. Disney, R. Strack, S. Jaffrey, 2016, ACS chemical biology.

Targeting the SARS-CoV-2 RNA Genome with Small Molecule Binders and Ribonuclease Targeting Chimera (RIBOTAC) Degraders

Hafeez S Haniff, Jonathan L Chen, Collin A O'Leary, 2020, ACS central science.

Design of a Small Molecule That Stimulates VEGFA Informed from an Expanded Encyclopedia of RNA Fold-Small Molecule Interactions

Hafeez S Haniff, M. Disney, Malin Lemurell, 2019 .

Molecular recognition by the Candida albicans group I intron: tertiary interactions with an imino G.A pair facilitate binding of the 5' exon and lower the KM for guanosine.

D. Turner, M. Disney, 2002, Biochemistry.

Binding enhancement by tertiary interactions and suicide inhibition of a Candida albicans group I intron by phosphoramidate and 2'-O-methyl hexanucleotides.

D. Turner, M. Disney, S. Gryaznov, 2001, Biochemistry.

Recognition elements for 5' exon substrate binding to the Candida albicans group I intron.

D. Turner, M. Disney, C. Haidaris, 2001, Biochemistry.

Discovery of a Biomarker and Lead Small Molecules to Target r(GGGGCC)-Associated Defects in c9FTD/ALS

Robert H. Brown, L. Petrucelli, B. Boeve, 2014, Neuron.

Rational design of bioactive, modularly assembled aminoglycosides targeting the RNA that causes myotonic dystrophy type 1.

Jessica L. Childs-Disney, M. Disney, R. Parkesh, 2012, ACS chemical biology.

Rational design of ligands targeting triplet repeating transcripts that cause RNA dominant disease: application to myotonic muscular dystrophy type 1 and spinocerebellar ataxia type 3.

Jessica L. Childs-Disney, M. Disney, K. Sobczak, 2009, Journal of the American Chemical Society.

Studying modification of aminoglycoside antibiotics by resistance-causing enzymes via microarray.

M. Disney, 2012, Methods in molecular biology.

Study of an RNA-Focused DNA-Encoded Library Informs Design of a Degrader of a r(CUG) Repeat Expansion.

M. Disney, A. Taghavi, H. Aikawa, 2022, Journal of the American Chemical Society.

A Crystal Structure of a Model of the Repeating r(CGG) Transcript Found in Fragile X Syndrome

M. Disney, K. Nettles, P. Fang, 2011, Chembiochem : a European journal of chemical biology.

Myotonic dystrophy type 1 RNA crystal structures reveal heterogeneous 1 × 1 nucleotide UU internal loop conformations.

M. Disney, K. Nettles, R. Parkesh, 2011, Biochemistry.

NMR Spectroscopy and Molecular Dynamics Simulation of r(CCGCUGCGG)2 Reveal a Dynamic UU Internal Loop Found in Myotonic Dystrophy Type 1 - UU pair with zero hydrogen bond pairs

M. Disney, R. Parkesh, M. Fountain, 2011 .

Low-Molecular Weight Small Molecules Can Potently Bind RNA and Affect Oncogenic Pathways in Cells.

M. Disney, Gogce Crynen, A. Taghavi, 2022, Journal of the American Chemical Society.

A meditation on accelerating the development of small molecule medicines targeting RNA

Jessica L. Childs-Disney, M. Disney, Xueyi Yang, 2022, Expert opinion on drug discovery.

Inhibiting Translation One Protein at a Time.

M. Disney, 2017, Trends in biochemical sciences.

Aminoglycoside microarrays to explore interactions of antibiotics with RNAs and proteins.

M. Disney, P. Seeberger, 2004, Chemistry.

Uptake and antifungal activity of oligonucleotides in Candida albicans

D. Turner, M. Disney, C. Haidaris, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Promoter-Bound Trinucleotide Repeat mRNA Drives Epigenetic Silencing in Fragile X Syndrome

M. Disney, S. Jaffrey, N. Zaninovic, 2014, Science.

A small molecule that binds an RNA repeat expansion stimulates its decay via the exosome complex

Jonathan L Chen, Ilyas Yildirim, M. Disney, 2020, bioRxiv.

Precise Targeted Cleavage of a r(CUG) Repeat Expansion in Cells by Using a Small-Molecule-Deglycobleomycin Conjugate.

D. Boger, M. Disney, Alicia J. Angelbello, 2020, ACS chemical biology.

Target-Directed Approaches for Screening Small Molecules against RNA Targets

Hafeez S Haniff, Laurent Knerr, Jonathan L Chen, 2020, SLAS discovery : advancing life sciences R & D.

Rational and modular design of potent ligands targeting the RNA that causes myotonic dystrophy 2.

M. Disney, A. Pushechnikov, Melissa M. Lee, 2009, ACS chemical biology.

Small molecule microarrays of RNA-focused peptoids help identify inhibitors of a pathogenic group I intron.

M. Disney, Lucas P Labuda, A. Pushechnikov, 2009, ACS chemical biology.

A small molecule microarray platform to select RNA internal loop-ligand interactions.

Matthew D Disney, Jessica L. Childs-Disney, Olga Aminova, 2007, ACS chemical biology.

Using Selection to Identify and Chemical Microarray to Study the RNA Internal Loops Recognized by 6′‐N‐Acylated Kanamycin A

Jessica L. Childs-Disney, M. Disney, Jessica L. Childs‐Disney, 2007, Chembiochem : a European journal of chemical biology.

N‐Linked Glycosylated β‐Peptides Are Resistant to Degradation by Glycoamidase A

M. Disney, D. Seebach, P. Seeberger, 2005 .

Controlling the specificity of modularly assembled small molecules for RNA via ligand module spacing: targeting the RNAs that cause myotonic muscular dystrophy.

Jessica L. Childs-Disney, M. Disney, K. Sobczak, 2009, Journal of the American Chemical Society.

Influencing uptake and localization of aminoglycoside-functionalized peptoids.

M. Disney, Jonathan M. French, Melissa M. Lee, 2011, Molecular bioSystems.

Inforna 2.0: A Platform for the Sequence-Based Design of Small Molecules Targeting Structured RNAs.

Matthew D Disney, Mohammad Fallahi, Mark Southern, 2016, ACS chemical biology.

Sequence-based design of bioactive small molecules that target precursor microRNAs

Steven M. Gallo, Matthew D. Disney, M. Disney, 2014, Nature chemical biology.

Structural Features of Small Molecules Targeting the RNA Repeat Expansion That Causes Genetically Defined ALS/FTD.

Jonathan L Chen, L. Petrucelli, Ilyas Yildirim, 2020, ACS chemical biology.

Precise Small Molecule Degradation of a Noncoding RNA Identifies Cellular Binding Sites and Modulates an Oncogenic Phenotype.

M. Disney, Yue Li, 2018, ACS chemical biology.

Thermodynamics of RNA-RNA duplexes with 2- or 4-thiouridines: implications for antisense design and targeting a group I intron.

D. Turner, R. Kierzek, M. Disney, 1999, Biochemistry.

Small molecule recognition of disease-relevant RNA structures.

Jessica L. Childs-Disney, M. Disney, Toru Tanaka, 2020, Chemical Society reviews.

Design of a small molecule that stimulates vascular endothelial growth factor A enabled by screening RNA fold–small molecule interactions

Hafeez S Haniff, Ilyas Yildirim, M. Disney, 2020, Nature Chemistry.

How We Think about Targeting RNA with Small Molecules.

Hafeez S Haniff, Jessica L. Childs-Disney, M. Disney, 2020, Journal of medicinal chemistry.

A Designed Small Molecule Inhibitor of a Non-Coding RNA Sensitizes HER2 Negative Cancers to Herceptin.

Jessica L. Childs-Disney, M. Disney, A. Adibekian, 2019, Journal of the American Chemical Society.

Drugging the RNA World.

Jessica L. Childs-Disney, M. Disney, Brendan G. Dwyer, 2018, Cold Spring Harbor perspectives in biology.

Computational Tools for Design of Selective Small Molecules Targeting RNA: From Small Molecule Microarrays to Chemical Similarity Searching

Jessica L. Childs-Disney, M. Disney, Matthew G. Costales, 2017 .

Defining RNA motif-aminoglycoside interactions via two-dimensional combinatorial screening and structure-activity relationships through sequencing.

M. Disney, S. P. Velagapudi, 2013, Bioorganic & medicinal chemistry.

Two-dimensional combinatorial screening identifies specific 6'-acylated kanamycin A- and 6'-acylated neamine-RNA hairpin interactions.

Matthew D Disney, Jessica L. Childs-Disney, Olga Aminova, 2008, Biochemistry.

Studying aminoglycoside modification by the acetyltransferase class of resistance-causing enzymes via microarray.

M. Disney, Meilan Wu, A. Pushechnikov, 2008, Carbohydrate research.

Approaches to Validate and Manipulate RNA Targets with Small Molecules in Cells.

Jessica L. Childs-Disney, M. Disney, Jessica L. Childs‐Disney, 2016, Annual review of pharmacology and toxicology.

Gini coefficients as a single value metric to define chemical probe selectivity.

Jessica L. Childs-Disney, M. Disney, Alicia J. Angelbello, 2020, ACS chemical biology.

Small Molecule Targeting of a MicroRNA Associated with Hepatocellular Carcinoma.

Jessica L. Childs-Disney, M. Disney, Jessica L. Childs‐Disney, 2016, ACS chemical biology.

Sequestration of DROSHA and DGCR8 by expanded CGG RNA repeats alters microRNA processing in fragile X-associated tremor/ataxia syndrome.

Peter K. Todd, M. Disney, P. Hagerman, 2013, Cell reports.

Inhibition of Non-ATG Translational Events in Cells via Covalent Small Molecules Targeting RNA.

Henry D. Wilson, M. Disney, S. P. Velagapudi, 2015, Journal of the American Chemical Society.

Analysis of secondary structural elements in human microRNA hairpin precursors

Dan Wang, Brent M. Znosko, Steven M. Gallo, 2016, BMC Bioinformatics.

A mannan binding lectin is involved in cell–cell attachment in a toxic strain of Microcystis aeruginosa

E. Dittmann, M. Disney, P. Seeberger, 2006, Molecular microbiology.

Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathy

L. Petrucelli, D. Dickson, M. Disney, 2019, Molecular Neurodegeneration.

Progress toward the development of the small molecule equivalent of small interfering RNA.

Jessica L. Childs-Disney, M. Disney, R. I. Benhamou, 2020, Current opinion in chemical biology.

Small molecule targeting of RNA structures in neurological disorders

Jonathan L Chen, M. Disney, Alicia J. Angelbello, 2020, Annals of the New York Academy of Sciences.

Design of a bioactive small molecule that targets r(AUUCU) repeats in spinocerebellar ataxia 10

M. Disney, M. Southern, Wang-Yong Yang, 2016, Nature Communications.

Targeted Degradation of a Hypoxia-Associated Non-coding RNA Enhances the Selectivity of a Small Molecule Interacting with RNA.

M. Disney, Matthew G. Costales, B. Suresh, 2019, Cell chemical biology.

Small Molecule Inhibition of microRNA-210 Reprograms an Oncogenic Hypoxic Circuit.

Matthew D Disney, Donald G Phinney, Jessica L. Childs-Disney, 2017, Journal of the American Chemical Society.

Small molecule chemical probes of microRNA function.

M. Disney, S. P. Velagapudi, Balayeshwanth R. Vummidi, 2015, Current opinion in chemical biology.

Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer

Eric T. Wang, Jessica L. Childs-Disney, E. Wang, 2020, Proceedings of the National Academy of Sciences.

A small molecule that targets r(CGG)(exp) and improves defects in fragile X-associated tremor ataxia syndrome.

Matthew D Disney, Jessica L. Childs-Disney, Jessica L Childs-Disney, 2012, ACS chemical biology.

New approaches to targeting RNA with oligonucleotides: inhibition of group I intron self-splicing.

D. Turner, M. Disney, Jessica L. Childs, 2004, Biopolymers.

Reprogramming of Protein-Targeted Small-Molecule Medicines to RNA by Ribonuclease Recruitment.

Jessica L. Childs-Disney, M. Disney, Toru Tanaka, 2021, Journal of the American Chemical Society.

Two-dimensional combinatorial screening enables the bottom-up design of a microRNA-10b inhibitor.

M. Disney, S. P. Velagapudi, 2014, Chemical communications.

A general fragment-based approach to identify and optimize bioactive ligands targeting RNA

Ilyas Yildirim, M. Disney, Christopher G. Parker, 2020, Proceedings of the National Academy of Sciences.

Defining RNA–Small Molecule Affinity Landscapes Enables Design of a Small Molecule Inhibitor of an Oncogenic Noncoding RNA

Hafeez S Haniff, Jessica L. Childs-Disney, M. Disney, 2017, ACS central science.

Rational Design of Small Molecules Targeting Oncogenic Noncoding RNAs from Sequence.

M. Disney, Alicia J. Angelbello, 2016, Accounts of chemical research.

Design of a small molecule against an oncogenic noncoding RNA

Matthew D Disney, Donald G Phinney, M. Disney, 2016, Proceedings of the National Academy of Sciences.

A map of the SARS-CoV-2 RNA structurome

Hafeez S Haniff, Walter N. Moss, Collin A O'Leary, 2021, NAR genomics and bioinformatics.

An in silico map of the SARS-CoV-2 RNA Structurome

Hafeez S Haniff, Jonathan L Chen, Walter N. Moss, 2020, bioRxiv.

The RNA encoding the microtubule-associated protein tau has extensive structure that affects its biology

Jonathan L Chen, Walter N. Moss, Jessica L. Childs-Disney, 2019, bioRxiv.

Design of small molecules targeting RNA structure from sequence.

Matthew D Disney, Andrei Ursu, Walter N. Moss, 2020, Chemical Society reviews.

Progress towards the development of the small molecule equivalent of small interfering RNA (siRNA)

Jessica L. Childs-Disney, M. Disney, R. I. Benhamou, 2020 .

Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA

Walter N. Moss, Jessica L. Childs-Disney, M. Disney, 2020, Proceedings of the National Academy of Sciences.

Oligonucleotide directed misfolding of RNA inhibits Candida albicans group I intron splicing

Douglas H. Turner, Matthew D. Disney, D. Turner, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Lomofungin and dilomofungin: inhibitors of MBNL1-CUG RNA binding with distinct cellular effects

Catherine Z. Chen, Noel Southall, C. Austin, 2014, Nucleic acids research.

Rationally designed small molecules targeting the RNA that causes myotonic dystrophy type 1 are potently bioactive.

Jessica L. Childs-Disney, M. Disney, C. Thornton, 2012, ACS chemical biology.

Structure-Specific Cleavage of an RNA Repeat Expansion with a Dimeric Small Molecule Is Advantageous over Sequence-Specific Recognition by an Oligonucleotide.

E. Wang, M. Disney, W. Moss, 2020, ACS chemical biology.

Two-dimensional combinatorial screening and the RNA Privileged Space Predictor program efficiently identify aminoglycoside–RNA hairpin loop interactions

Steven J. Seedhouse, M. Disney, Dustin J. Paul, 2009, Nucleic acids research.

A Druglike Small Molecule that Targets r(CCUG) Repeats in Myotonic Dystrophy Type 2 Facilitates Degradation by RNA Quality Control Pathways.

Jonathan L Chen, Jessica L. Childs-Disney, M. Disney, 2021, Journal of medicinal chemistry.

A Toxic RNA Catalyzes the Cellular Synthesis of Its Own Inhibitor, Shunting It to Endogenous Decay Pathways

E. Wang, M. Disney, R. I. Benhamou, 2019, bioRxiv.

Small Molecule Targeted Recruitment of a Nuclease to RNA.

M. Disney, S. P. Velagapudi, Matthew G. Costales, 2018, Journal of the American Chemical Society.

Affecting RNA biology genome-wide by binding small molecules and chemically induced proximity.

Jessica L. Childs-Disney, M. Disney, Jared T. Baisden, 2021, Current opinion in chemical biology.

Covalent small-molecule-RNA complex formation enables cellular profiling of small-molecule-RNA interactions.

M. Disney, L. Guan, 2013, Angewandte Chemie.

DNA-encoded library versus RNA-encoded library selection enables design of an oncogenic noncoding RNA inhibitor

Jessica L. Childs-Disney, M. Disney, Valerie Cavett, 2022, Proceedings of the National Academy of Sciences.

Poly(Gp) Proteins Are A Useful Pharmacodynamic Marker For C9Orf72-Associated Amyotrophic Lateral Sclerosis

William T. Hu, Robert H. Brown, L. Petrucelli, 2017 .

Bioinformatic Searching for Optimal RNA Targets of Dimeric Compounds Informs Design of a MicroRNA-27a Inhibitor.

M. Disney, R. I. Benhamou, S. Choudhary, 2021, ACS chemical biology.

The Hairpin Form of r(G4C2)exp in c9ALS/FTD Is Repeat-Associated Non-ATG Translated and a Target for Bioactive Small Molecules.

Jessica L. Childs-Disney, L. Petrucelli, Ilyas Yildirim, 2019, Cell chemical biology.

Targeted Degradation of the Oncogenic MicroRNA 17-92 Cluster by Structure-Targeting Ligands.

Hafeez S Haniff, Jessica L. Childs-Disney, M. Disney, 2020, Journal of the American Chemical Society.

Dihydro‐2(3H)‐thiophenimine Hydrochloride

M. Disney, A. Pushechnikov, 2009 .

A superfolding Spinach2 reveals the dynamic nature of trinucleotide repeat RNA

Samie R. Jaffrey, Matthew D. Disney, M. Disney, 2013, Nature Methods.

Miniaturization of Microwave‐Assisted Carbohydrate Functionalization to Create Oligosaccharide Microarrays

M. Disney, P. Seeberger, M. Brun, 2006, Chembiochem : a European journal of chemical biology.

Molecular recognition of 6'-N-5-hexynoate kanamycin A and RNA 1x1 internal loops containing CA mismatches.

M. Disney, T. Tran, 2011, Biochemistry.

A blood–brain penetrant RNA-targeted small molecule triggers elimination of r(G4C2)exp in c9ALS/FTD via the nuclear RNA exosome

Jessica L. Childs-Disney, L. Petrucelli, M. Disney, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G4C2) repeat expansion in vitro and in vivo ALS models

Eric T. Wang, Jonathan L Chen, Jessica L. Childs-Disney, 2021, Science Translational Medicine.

DNA-Encoded Library Screening To Inform Design of a Ribonuclease Targeting Chimera (RiboTAC).

M. Disney, A. Adibekian, M. Cameron, 2022, Journal of the American Chemical Society.

Two-dimensional combinatorial screening identifies specific aminoglycoside-RNA internal loop partners.

Matthew D Disney, Jessica L. Childs-Disney, Jessica L Childs-Disney, 2008, Journal of the American Chemical Society.

Discovery of a Biomarker and Lead Small Molecules to Target r(GGGGCC)-Associated Defects in c9FTD/ALS

Peter K. Todd, Robert H. Brown, L. Petrucelli, 2014, Neuron.

Hybridization-based unquenching of DNA hairpins on au surfaces: prototypical "molecular beacon" biosensors.

Matthew D Disney, Benjamin L Miller, Hui Du, 2003, Journal of the American Chemical Society.

Optimization of the Linker Domain in a Dimeric Compound that Degrades an r(CUG) Repeat Expansion in Cells.

M. Disney, R. I. Benhamou, Alicia J. Angelbello, 2020, Journal of medicinal chemistry.

Crystallographic and Computational Analyses of AUUCU Repeating RNA That Causes Spinocerebellar Ataxia Type 10 (SCA10).

Ilyas Yildirim, M. Disney, P. Fang, 2015, Biochemistry.

Computational Investigation of RNA A-Bulges Related to the Microtubule-Associated Protein Tau Causing Frontotemporal Dementia and Parkinsonism.

D. Wales, Ilyas Yildirim, M. Disney, 2018, The journal of physical chemistry. B.

Chemical Microarrays to Identify Ligands that Bind Pathogenic Cells

M. Disney, Jessica L. Childs, Olivia J Barrett, 2006, Chembiochem : a European journal of chemical biology.

Precise small-molecule cleavage of an r(CUG) repeat expansion in a myotonic dystrophy mouse model

Eric T. Wang, Jonathan L Chen, Walter N. Moss, 2019, Proceedings of the National Academy of Sciences.

Development of MAPT S305 mutation models exhibiting elevated 4R tau expression, resulting in altered neuronal and astrocytic function

M. Disney, A. Goate, Y. Liu, 2023, bioRxiv.

Small-molecule-mediated cleavage of RNA in living cells.

M. Disney, L. Guan, 2013, Angewandte Chemie.

A structure-specific small molecule inhibits a miRNA-200 family member precursor and reverses a type 2 diabetes phenotype.

Hafeez S Haniff, M. Disney, Malin Lemurell, 2021, Cell chemical biology.

Small molecules exploiting structural differences within microRNA-200 precursors family members reverse a type 2 diabetes phenotype

Hafeez S Haniff, M. Disney, Malin Lemurell, 2020, bioRxiv.

Computational Investigation of RNA CUG Repeats Responsible for Myotonic Dystrophy 1

George C. Schatz, David J. Wales, Debayan Chakraborty, 2015, Journal of chemical theory and computation.

Features of modularly assembled compounds that impart bioactivity against an RNA target.

M. Disney, T. Kodadek, C. Thornton, 2013, ACS chemical biology.

The Role of Flexibility in the Rational Design of Modularly Assembled Ligands Targeting the RNAs that Cause the Myotonic Dystrophies

Jessica L. Childs-Disney, M. Disney, A. Pushechnikov, 2010, Chembiochem : a European journal of chemical biology.

Conformational dynamics of RNA G4C2 and G2C4 repeat expansions causing ALS/FTD using NMR and molecular dynamics studies

Jessica L. Childs-Disney, Ilyas Yildirim, M. Disney, 2023, Nucleic acids research.

A Small Molecule Exploits Hidden Structural Features within the RNA Repeat Expansion That Causes c9ALS/FTD and Rescues Pathological Hallmarks.

L. Petrucelli, Ilyas Yildirim, M. Disney, 2021, ACS chemical neuroscience.

Identifying and validating small molecules interacting with RNA (SMIRNAs).

Jessica L. Childs-Disney, M. Disney, S. P. Velagapudi, 2019, Methods in enzymology.

Fragment-Based Approaches to Identify RNA Binders.

M. Disney, A. Taghavi, B. Suresh, 2023, Journal of medicinal chemistry.

Identifying the Preferred RNA Motifs and Chemotypes that Interact by Probing Millions of Combinations

Matthew D. Disney, M. Disney, Tuan Tran, 2012, Nature Communications.

Defining the RNA internal loops preferred by benzimidazole derivatives via 2D combinatorial screening and computational analysis.

Steven J. Seedhouse, M. Disney, S. P. Velagapudi, 2011, Journal of the American Chemical Society.

Probing a 2-aminobenzimidazole library for binding to RNA internal loops via two-dimensional combinatorial screening.

M. Disney, Lucas P Labuda, S. P. Velagapudi, 2012, ACS chemical biology.

An aminoglycoside microarray platform for directly monitoring and studying antibiotic resistance.

M. Disney, Olivia J Barrett, 2007, Biochemistry.

Bleomycin Can Cleave an Oncogenic Noncoding RNA

M. Disney, Alicia J. Angelbello, 2018, Chembiochem : a European journal of chemical biology.

Systematically Studying the Effect of Small Molecules Interacting with RNA in Cellular and Preclinical Models.

Hafeez S Haniff, M. Disney, Yuquan Tong, 2021, ACS chemical biology.

Programming inactive RNA-binding small molecules into bioactive degraders

Hafeez S Haniff, F. Glorius, M. Disney, 2023, Nature.

Macrocyclization of a Ligand Targeting a Toxic RNA Dramatically Improves Potency

Ilyas Yildirim, M. Disney, Simon Vezina-Dawod, 2020, Chembiochem : a European journal of chemical biology.

DNA‐Encoded Libraries and Their Application to RNA

M. Disney, Xueyi Yang, Jessica L. Childs‐Disney, 2023, Israel Journal of Chemistry.

Inhibition of Non-ATG Translational Events in Cells via Covalent Small Molecules Targeting RNA.

Henry D. Wilson, M. Disney, S. P. Velagapudi, 2015, Journal of the American Chemical Society.

Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis

Timothy A. Miller, L. Petrucelli, J. Trojanowski, 2017, Science Translational Medicine.

Roadmap for C9ORF72 in Frontotemporal Dementia and Amyotrophic Lateral Sclerosis: Report on the C9ORF72 FTD/ALS Summit

B. Traynor, M. Disney, J. Shefner, 2023, Neurology and Therapy.

Short-circuiting RNA splicing.

M. Disney, 2008, Nature chemical biology.

A simple ligation-based method to increase the information density in sequencing reactions used to deconvolute nucleic acid selections.

M. Disney, Jessica L. Childs‐Disney, 2007, RNA.

Small Molecule Inhibition of microRNA-210 Reprograms an Oncogenic Hypoxic Circuit.

M. Disney, D. Phinney, C. L. Haga, 2017, Journal of the American Chemical Society.