C. Dardonville

发表

Validation of novel fluorescence assays for the routine screening of drug susceptibilities of Trichomonas vaginalis.

Manal J. Natto, F. Savioli, N. Quashie, 2012, The Journal of antimicrobial chemotherapy.

Prediction of Aqueous pKa Values for Guanidine-Containing Compounds Using Ab Initio Gas-Phase Equilibrium Bond Lengths

Beth A. Caine, C. Dardonville, P. Popelier, 2018, ACS omega.

Synthesis and biological evaluation of substrate-based inhibitors of 6-phosphogluconate dehydrogenase as potential drugs against African trypanosomiasis.

Stefania Hanau, Christophe Dardonville, Michael P Barrett, 2003, Bioorganic & medicinal chemistry.

A New Nonpolar N-Hydroxy Imidazoline Lead Compound with Improved Activity in a Murine Model of Late-Stage Trypanosoma brucei brucei Infection Is Not Cross-Resistant with Diamidines

C. Dardonville, H. D. de Koning, F. Miller, 2014, Antimicrobial Agents and Chemotherapy.

Synthesis and antiprotozoal activity of N-alkoxy analogues of the trypanocidal lead compound 4,4'-bis(imidazolinylamino)diphenylamine with improved human blood-brain barrier permeability.

C. Dardonville, A. Mascaraque, F. Miller, 2011, Journal of medicinal chemistry.

Recent advances in antitrypanosomal chemotherapy: patent literature 2002 – 2004

C. Dardonville, 2005 .

Bisimidazoline arylamides binding to the DNA minor groove: N1-hydroxylation enhances binding affinity and selectivity to AATT sites

C. Dardonville, Cristina Trujillo, L. Lagartera, 2015 .

Antiprotozoal activity and DNA binding of dicationic acridones.

C. Dardonville, M. Kaiser, A. Taladriz-Sender, 2015, Journal of medicinal chemistry.

The behavior of 5H-dibenz[b,f]azepine in sulfuric acid solution

C. Dardonville, J. Elguero, I. Alkorta, 2004 .

Aqueous pKa prediction for tautomerizable compounds using equilibrium bond lengths

Beth A. Caine, C. Dardonville, P. Popelier, 2019, Communications Chemistry.

The structure of fosfomycin salts in solution and in the solid state by nuclear magnetic resonance spectroscopy and DFT calculations

C. Dardonville, J. Elguero, I. Alkorta, 2018, Tetrahedron.

Inhibition of trypanosome alternative oxidase without its N-terminal mitochondrial targeting signal (ΔMTS-TAO) by cationic and non-cationic 4-hydroxybenzoate and 4-alkoxybenzaldehyde derivatives active against T. brucei and T. congolense.

C. Dardonville, H. D. de Koning, M. Kaiser, 2018, European journal of medicinal chemistry.

Bisguanidine, bis(2-aminoimidazoline), and polyamine derivatives as potent and selective chemotherapeutic agents against Trypanosoma brucei rhodesiense. Synthesis and in vitro evaluation.

C. Dardonville, R. Brun, 2004, Journal of medicinal chemistry.

Lowering the pKa of a bisimidazoline lead with halogen atoms results in improved activity and selectivity against Trypanosoma brucei in vitro.

C. Dardonville, H. D. de Koning, I. Alkorta, 2015, European journal of medicinal chemistry.

SAR Studies of Diphenyl Cationic Trypanocides: Superior Activity of Phosphonium over Ammonium Salts.

C. Dardonville, H. D. de Koning, Abdulsalam A. M. Alkhaldi, 2015, ACS medicinal chemistry letters.

Synthesis and pharmacological studies of new hybrid derivatives of fentanyl active at the mu-opioid receptor and I2-imidazoline binding sites.

C. Dardonville, Gary J. Ryan, L. Callado, 2006, Bioorganic & medicinal chemistry.

Imidazoline binding sites and their ligands: An overview of the different chemical structures

C. Dardonville, I. Rozas, 2004, Medicinal research reviews.

I(2)-imidazoline binding site affinity of a structurally different type of ligands.

C. Dardonville, L. Callado, J. Meana, 2002, Bioorganic & medicinal chemistry.

Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei

F. Svensson, C. Dardonville, H. D. de Koning, 2020, bioRxiv.

Homoheteroaromaticity: the case study of azepine and dibenzazepine.

C. Dardonville, J. Elguero, I. Alkorta, 2004, Organic & biomolecular chemistry.

Observation of diastereotopic signals in (15) N NMR spectroscopy.

C. Dardonville, J. Elguero, I. Alkorta, 2015, Angewandte Chemie.

An experimental (flash vacuum pyrolysis) and theoretical study of the tautomerism of pyrazolinones at high temperatures

C. Dardonville, J. Elguero, E. L. Moyano, 1999 .

Synthesis, biological, and photophysical studies of molecular rotor-based ﬂ uorescent inhibitors of the trypanosome alternative oxidase European Journal of Medicinal Chemistry

C. Dardonville, R. Salto, M. Girón, 2021 .

New benzophenone-derived bisphosphonium salts as leishmanicidal leads targeting mitochondria through inhibition of respiratory complex II.

C. Dardonville, L. Rivas, J. R. Luque-Ortega, 2010, Journal of medicinal chemistry.

DNA binding affinity of bisguanidine and bis(2-aminoimidazoline) derivatives with in vivo antitrypanosomal activity.

M. Barrett, C. Dardonville, W. Wilson, 2006, Journal of medicinal chemistry.

Synthesis of (R)-2-methyl-4-deoxy and (R)-2-methyl-4,5-dideoxy analogues of 6-phosphogluconate as potential inhibitors of 6-phosphogluconate dehydrogenase.

I. Gilbert, C. Dardonville, 2003, Organic & biomolecular chemistry.

Discovery of nitroheterocycles active against African trypanosomes. In vitro screening and preliminary SAR studies.

C. Dardonville, V. Arán, M. Kaiser, 2012, Bioorganic & medicinal chemistry letters.

Synthesis and analgesic activity of a series of new azaalkane bis-guanidinium and bis(2-aminoimidazolinium) compounds.

C. Dardonville, I. Rozas, C. Goicoechea, 2003, Bioorganic & medicinal chemistry.

New aromatic iminoimidazolidine derivatives as alpha1-adrenoceptor antagonists: a novel synthetic approach and pharmacological activity.

C. Dardonville, M. Borrego, I. Rozas, 2000, Bioorganic & medicinal chemistry.

New bis(2-aminoimidazoline) and bisguanidine DNA minor groove binders with potent in vivo antitrypanosomal and antiplasmodial activity.

Binh Nguyen, Marcel Kaiser, Christophe Dardonville, 2008, Journal of medicinal chemistry.

Tautomerism of 1-(2′,4′-dinitrophenyl)-3-methyl-2-pyrazolin-5-one: theoretical calculations, solid and solution NMR studies and X-ray crystallography

C. Dardonville, J. Elguero, I. Sobrados, 1998 .

Synthesis, biological, and photophysical studies of molecular rotor-based fluorescent inhibitors of the trypanosome alternative oxidase.

C. Dardonville, H. D. de Koning, R. Salto, 2021, European journal of medicinal chemistry.

SAR of 4-Alkoxybenzoic Acid Inhibitors of the Trypanosome Alternative Oxidase.

C. Dardonville, H. D. de Koning, G. Ebiloma, 2018, ACS medicinal chemistry letters.

Functional and structural analysis of AT-specific minor groove binders that disrupt DNA–protein interactions and cause disintegration of the Trypanosoma brucei kinetoplast

C. Dardonville, H. D. de Koning, N. Saperas, 2017, Nucleic acids research.

Conjugates of 2,4-Dihydroxybenzoate and Salicylhydroxamate and Lipocations Display Potent Antiparasite Effects by Efficiently Targeting the Trypanosoma brucei and Trypanosoma congolense Mitochondrion.

C. Dardonville, H. D. de Koning, K. Kita, 2017, Journal of medicinal chemistry.

Synthesis and structure-activity analysis of new phosphonium salts with potent activity against African trypanosomes.

C. Dardonville, H. D. de Koning, M. Kaiser, 2012, Journal of medicinal chemistry.

Synthesis and Structure-Activity Analysis of New Phosphonium Salts with Potent Activity Against

C. Dardonville, A. Healy, Antonio Chana, 2012 .

Alternative oxidase inhibitors: Mitochondrion‐targeting as a strategy for new drugs against pathogenic parasites and fungi

C. Dardonville, H. D. de Koning, G. Ebiloma, 2019, Medicinal research reviews.

Influence of ornithine decarboxylase antizymes and antizyme inhibitors on agmatine uptake by mammalian cells

C. Dardonville, B. Ramos-Molina, R. Peñafiel, 2015, Amino Acids.

Antiprotozoal Activity of 1-Phenethyl-4-Aminopiperidine Derivatives

C. Dardonville, R. Brun, Gary J. Ryan, 2009, Antimicrobial Agents and Chemotherapy.

6-phosphogluconate dehydrogenase: a target for drugs in African trypanosomes.

I. Gilbert, M. Barrett, C. Dardonville, 2004, Current medicinal chemistry.

Rapid Determination of Ionization Constants (pK a) by UV Spectroscopy Using 96-Well Microtiter Plates.

C. Dardonville, C. Martínez, 2013, ACS medicinal chemistry letters.

Crystal structure of a trypanocidal 4,4'-bis(imidazolinylamino)diphenylamine bound to DNA.

C. Dardonville, M. Georgiadis, W. Wilson, 2009, Biochemistry.

Discovery and pharmacological studies of 4-hydroxyphenyl-derived phosphonium salts active in a mouse model of visceral leishmaniasis.

C. Dardonville, F. Gamarro, J. Torrado, 2019, Journal of medicinal chemistry.

Trypanocidal action of bisphosphonium salts through a mitochondrial target in bloodstream form Trypanosoma brucei

C. Dardonville, H. D. de Koning, A. Zíková, 2015, International journal for parasitology. Drugs and drug resistance.

Positively selected modifications in the pore of TbAQP 2 allow pentamidine to enter 1

Mark C. Field, C. Dardonville, Arvind Kumar, 2022 .

Aqueous pKa prediction for tautomerizable compounds using equilibrium bond lengths

Beth A. Caine, C. Dardonville, P. Popelier, 2019, Communications Chemistry.

In and out of the minor groove: interaction of an AT-rich DNA with the drug CD27

Manal, Manal J. Natto, C. Dardonville, 2014, Acta crystallographica. Section D, Biological crystallography.

Fentanyl derivatives bearing aliphatic alkaneguanidinium moieties: a new series of hybrid molecules with significant binding affinity for mu-opioid receptors and I2-imidazoline binding sites.

C. Dardonville, L. Callado, J. Meana, 2004, Bioorganic & medicinal chemistry letters.

Substituent effects on the basicity (pKa) of aryl guanidines and 2-(arylimino)imidazolidines: correlations of pH-metric and UV-metric values with predictions from gas-phase ab initio bond lengths

Paul L. A. Popelier, Christophe Dardonville, Beth A. Caine, 2017 .

Fentanyl Derivatives Bearing Aliphatic Alkaneguanidinium Moieties: A New Series of Hybrid Molecules with Significant Binding Affinity for μ-Opioid Receptors and I2-Imidazoline Binding Sites.

C. Dardonville, L. Callado, J. Meana, 2004 .

A theoretical and spectroscopic (NMR and IR) study of indirubin in solution and in the solid state

C. Dardonville, J. Elguero, Marta Marín‐Luna, 2020 .

Antiprotozoal activity and DNA binding of N-substituted N-phenylbenzamide and 1,3-diphenylurea bisguanidines.

C. Dardonville, M. Kaiser, Carlos H Ríos Martínez, 2014, European journal of medicinal chemistry.

Influence of ornithine decarboxylase antizymes and antizyme inhibitors on agmatine uptake by mammalian cells

C. Dardonville, B. Ramos-Molina, R. Peñafiel, 2015, Amino Acids.

Automated techniques in pKa determination: Low, medium and high-throughput screening methods.

Christophe Dardonville, C. Dardonville, 2018, Drug discovery today. Technologies.

Asymmetric synthesis of the left hand portion of the azinomycins

C. Dardonville, M. Hursthouse, M. Shipman, 1998 .

Imidazoline- and Benzamidine-Based Trypanosome Alternative Oxidase Inhibitors: Synthesis and Structure–Activity Relationship Studies

C. Dardonville, H. D. de Koning, Marzuq A. Ungogo, 2022, ACS medicinal chemistry letters.

Bis(2-aminoimidazolines) and Bisguanidines: Synthetic Approaches, Antiparasitic Activity and DNA Binding Properties.

C. Dardonville, J. J. N. Martinez, 2017, Current medicinal chemistry.

Synthesis and SAR studies of a new trypanosome alternative oxidase inhibitors: imidazoline and benzamidine derivatives

C. Dardonville, H. D. de Koning, T. Bernal, 2021, Proceedings of 7th International Electronic Conference on Medicinal Chemistry.

Solving a chemical challenge in the synthesis of antiprotozoal agents targeting the DNA minor groove: A high yield synthesis of trans-azoxybenzene

C. Dardonville, I. Alkorta, J. J. Nué-Martínez, 2021, Proceedings of 7th International Electronic Conference on Medicinal Chemistry.

High yield synthesis of trans-azoxybenzene versus 2-isopropoxy-4-nitrobenzoic acid: influence of temperature and base concentration

C. Dardonville, I. Alkorta, J. J. Nué-Martínez, 2021 .

Synthesis and Biophysical and Biological Studies of N-Phenylbenzamide Derivatives Targeting Kinetoplastid Parasites

C. Dardonville, H. D. de Koning, F. Gamarro, 2023, Journal of medicinal chemistry.

Selective inhibition of Trypanosoma brucei 6-phosphogluconate dehydrogenase by high-energy intermediate and transition-state analogues.

I. Gilbert, M. Barrett, C. Dardonville, 2004, Journal of medicinal chemistry.