A. Sousa

发表

Stratification of asthma phenotypes by airway proteomic signatures.

C. Auffray, P. Howarth, James P R Schofield, 2019, The Journal of allergy and clinical immunology.

Exacerbations in Adults with Asthma: A Systematic Review and External Validation of Prediction Models.

Peter J Sterk, Kian Fan Chung, Thomas P A Debray, 2018, The journal of allergy and clinical immunology. In practice.

Identifying patients at risk for severe exacerbations of asthma: development and external validation of a multivariable prediction model

W. Assendelft, A. Sousa, K. Chung, 2016, Thorax.

Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort

Ioannis Pandis, Charles Auffray, Thomas Sandström, 2015, European Respiratory Journal.

U‐BIOPRED clinical adult asthma clusters linked to a subset of sputum omics

Frédéric Baribaud, Ioannis Pandis, Charles Auffray, 2017, The Journal of allergy and clinical immunology.

Clinical and transcriptomic features of persistent exacerbation‐prone severe asthma in U‐BIOPRED cohort

C. Auffray, P. Howarth, A. Bansal, 2022, Clinical and translational medicine.

Morse-clustering of a Topological Data Analysis Network Identifies Phenotypes of Asthma Based on Blood Gene Expression Profiles

Ioannis Pandis, Charles Auffray, Jeannette Bigler, 2019, bioRxiv.

Treatable traits in the European U‐BIOPRED adult asthma cohorts

G. Roberts, A. Bansal, D. Shaw, 2018, Allergy.

Pathway discovery using transcriptomic profiles in adult‐onset severe asthma

Stelios Pavlidis, Charles Auffray, Bertrand De Meulder, 2017, The Journal of allergy and clinical immunology.

“T2-high” in severe asthma related to blood eosinophil, exhaled nitric oxide and serum periostin

C. Auffray, P. Howarth, Yike Guo, 2018, European Respiratory Journal.

Large-Scale Label-Free Quantitative Mapping of the Sputum Proteome.

C. Auffray, P. Howarth, James P R Schofield, 2018, Journal of proteome research.

Expression of interleukin-1 beta (IL-1beta) and interleukin-1 receptor antagonist (IL-1ra) on asthmatic bronchial epithelium.

A. Sousa, T. Lee, S. Lane, 1996, American journal of respiratory and critical care medicine.

Effect of endobronchial aspirin challenge on inflammatory cells in bronchial biopsy samples from aspirin-sensitive asthmatic subjects.

A. Sousa, R. Pfister, T. Lee, 1996, Thorax.

Increased expression of the monocyte chemoattractant protein-1 in bronchial tissue from asthmatic subjects.

A. Sousa, T. Lee, T. Yoshimura, 1994, American journal of respiratory cell and molecular biology.

A Severe Asthma Disease Signature from Gene Expression Profiling of Peripheral Blood from U‐BIOPRED Cohorts

C. Auffray, G. Roberts, James P R Schofield, 2017, American journal of respiratory and critical care medicine.

Airway Elastin is increased in severe asthma and relates to proximal wall area: histological and computed tomography findings from the U‐BIOPRED severe asthma study

P. Howarth, Susan J Wilson, J. Ward, 2020, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Elevated sputum interleukin-5 and submucosal eosinophilia in obese individuals with severe asthma.

I. Pavord, F. Symon, A. Sousa, 2013, American journal of respiratory and critical care medicine.

Safety and efficacy of an oral CCR3 antagonist in patients with asthma and eosinophilic bronchitis: a randomized, placebo‐controlled clinical trial

L. Boulet, C. Lemière, A. Sousa, 2014, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

The role of the macrophage in asthma

A. Sousa, T. Lee, S. Lane, 1994, Allergy.

Inflammatory cell populations in bronchial biopsies from aspirin-sensitive asthmatic subjects.

A. Sousa, R. Pfister, T. Lee, 1996, American journal of respiratory and critical care medicine.

Leukotriene-receptor expression on nasal mucosal inflammatory cells in aspirin-sensitive rhinosinusitis.

G. Scadding, A. Sousa, C. Corrigan, 2002, The New England journal of medicine.

Enhanced expression of cyclo-oxygenase isoenzyme 2 (COX-2) in asthmatic airways and its cellular distribution in aspirin-sensitive asthma.

A. Sousa, R. Pfister, T. Lee, 1997, Thorax.

Sputum transcriptomics reveal upregulation of IL‐1 receptor family members in patients with severe asthma

C. Auffray, A. Bansal, A. Rowe, 2017, The Journal of allergy and clinical immunology.

Temporal assessment of airway remodeling in severe asthma using quantitative computed tomography.

I. Pavord, A. Sousa, D. Subramanian, 2015, American journal of respiratory and critical care medicine.

In vivo resistance to corticosteroids in bronchial asthma is associated with enhanced phosyphorylation of JUN N-terminal kinase and failure of prednisolone to inhibit JUN N-terminal kinase phosphorylation.

A. Sousa, T. Lee, S. Lane, 1999, The Journal of allergy and clinical immunology.

Enhanced oxidative stress in smoking and ex-smoking severe asthma in the U-BIOPRED cohort

C. Auffray, P. Howarth, A. Bansal, 2018, PloS one.

Urinary metabotype of severe asthma evidences decreased carnitine metabolism independent of oral corticosteroid treatment in the U-BIOPRED study

P. Howarth, D. Shaw, P. Bakke, 2021, European Respiratory Journal.

Glucocorticoid-resistant asthma

A. Sousa, C. Hawrylowicz, C. Corrigan, 2004 .

The first U-BIOPRED blood handprint of severe asthma

C. Auffray, J. Corfield, D. Shaw, 2015 .

Detection of GM-CSF in asthmatic bronchial epithelium and decrease by inhaled corticosteroids.

A. Sousa, T. Lee, S. Lane, 1993, The American review of respiratory disease.

Responsiveness to oral prednisolone in severe asthma is related to the degree of eosinophilic airway inflammation

A. Sousa, B. Hargadon, Richard Graham Knowles, 2017, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Expression of interleukin-5 and granulocyte-macrophage colony-stimulating factor in aspirin-sensitive and non-aspirin-sensitive asthmatic airways.

A. Sousa, R. Pfister, T. Lee, 1997, American journal of respiratory and critical care medicine.

The effects of prednisolone on the cutaneous tuberculin response in patients with corticosteroid-resistant bronchial asthma.

A. Sousa, T. Lee, S. Lane, 1996, The Journal of allergy and clinical immunology.

Urinary Leukotriene E4 and Prostaglandin D2 Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type 2 Inflammation. A Clinical Observational Study

P. Howarth, D. Shaw, P. Bakke, 2020, American journal of respiratory and critical care medicine.

Glucocorticoid-resistant asthma

A. Sousa, C. Corrigan, T. Loke, 2002, Current allergy and asthma reports.

Distinct pathways underlying neutrophilic inflammation in smoking-associated severe asthma in U-BIOPRED

C. Auffray, P. Howarth, J. Corfield, 2017 .

External validation of blood eosinophils, FENO and serum periostin as surrogates for sputum eosinophils in asthma

R. Lutter, A. Sousa, P. Sterk, 2014, Thorax.

Characteristics of the frequent exacerbator in U-BIOPRED adult severe asthma cohort

P. Howarth, G. Roberts, A. Bansal, 2015 .

Safety, tolerability and pharmacokinetics (PK) of single and repeat nebulised doses of a novel phosphoinositide 3-kinase δ inhibitor (PI3Kδ), GSK2269557, administered to healthy male subjects in a phase I study

A. Sousa, C. Rambaran, I. McSherry, 2013 .

Clustering analysis of clinical variables in U-BIOPRED adult asthma cohort

C. Auffray, G. Roberts, A. Bansal, 2014 .

Rapid communication Effect of inhaled glucocorticoids on IL-1b and IL-1 receptor antagonist (IL-1ra) expression in asthmatic bronchial epithelium

A. Sousa, S. Lane, Tak H. Lee, 1998 .

Relationship between lung function and quantitative computed tomographic parameters of airway remodeling, air trapping, and emphysema in patients with asthma and chronic obstructive pulmonary disease: A single-center study

A. Sousa, S. Gupta, C. Newby, 2016, The Journal of allergy and clinical immunology.

Glucocorticoid resistance in asthma is associated with elevated in vivo expression of the glucocorticoid receptor β-isoform

A. Sousa, J. Cidlowski, T. Lee, 2000 .

Identification and prospective stability of electronic nose (eNose)–derived inflammatory phenotypes in patients with severe asthma

T. J. Vink, C. Auffray, M. Santonico, 2019, The Journal of allergy and clinical immunology.

Monocytes and Macrophages in Asthma.

A. Sousa, J. Arm, S. Lane, 1992, International archives of allergy and immunology.

A Topological Data Analysis Network Model of Asthma Based on Blood Gene Expression Profiles

Ioannis Pandis, Charles Auffray, Ben D. MacArthur, 2019 .

Reduced need for surgery in severe nasal polyposis with mepolizumab: Randomized trial

C. Bachert, S. Durham, W. Fokkens, 2017, The Journal of allergy and clinical immunology.

Transcriptomic gene signatures associated with persistent airflow limitation in patients with severe asthma

C. Auffray, P. Howarth, A. Bansal, 2017, European Respiratory Journal.

The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohorts

H. Bisgaard, G. Roberts, A. Bansal, 2015, European Respiratory Journal.

Lipid phenotyping of lung epithelial lining fluid in healthy human volunteers

C. Auffray, K. Bønnelykke, H. Bisgaard, 2018, Metabolomics.

C. Auffray, K. Bønnelykke, H. Bisgaard, 2019, Respiratory medicine.

Mepolizumab and exacerbations of refractory eosinophilic asthma.

Ana Sousa, Christopher E Brightling, Peter Bradding, 2009, The New England journal of medicine.

Epithelial IL‐6 trans‐signaling defines a new asthma phenotype with increased airway inflammation

P. Howarth, J. Ward, D. Shaw, 2019, The Journal of allergy and clinical immunology.

HIV-1 infection on Follicular Helper T cells

A. Sousa, 2017 .

Effect of inhaled glucocorticoids on IL-1 beta and IL-1 receptor antagonist (IL-1 ra) expression in asthmatic bronchial epithelium.

A. Sousa, T. Lee, S. Lane, 1997, Thorax.

IL-17-high asthma with features of a psoriasis immunophenotype.

C. Auffray, P. Howarth, J. Ward, 2019, The Journal of allergy and clinical immunology.

Subepithelial immunopathology of the large airways in smokers with and without chronic obstructive pulmonary disease.

A. Sousa, T. Lee, P. Rees, 2000, The European respiratory journal.

Quantitative computed tomography–derived clusters: Redefining airway remodeling in asthmatic patients☆

Salman Siddiqui, Deepak Subramanian, Amisha Singapuri, 2014, The Journal of allergy and clinical immunology.

Severe asthma: Differential chemokine response of airway epithelial cells.

A. Sousa, P. Andrew, R. Hirst, 2017, The Journal of allergy and clinical immunology.

Discordant use of short‐acting β2 agonists in children and adults with severe, uncontrolled asthma from the U‐BIOPRED cohort

G. Roberts, A. Sousa, I. Adcock, 2020, Pediatric pulmonology.

Severe asthma exists despite suppressed tissue inflammation: findings of the U-BIOPRED study

C. Auffray, P. Howarth, A. Bansal, 2016, European Respiratory Journal.

Immunopathology of the small-airway submucosa in smokers with and without chronic obstructive pulmonary disease.

A. Sousa, T. Lee, B. Lams, 1998, American journal of respiratory and critical care medicine.

Epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux

C. Auffray, P. Howarth, Fabio Strazzeri, 2019, European Respiratory Journal.

Anti-allergic drug testing in an environmental challenge chamber is suitable both in and out of the relevant pollen season.

N. Krug, A. Sousa, J. Hohlfeld, 2011, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

Synthetic Response of Stimulated Respiratory Epithelium

A. Sousa, C. Brightling, R. Williamson, 2012, Chest.

Synthetic response of stimulated respiratory epithelium: Modulation by prednisolone and iKK2 inhibition

A. Sousa, C. Brightling, R. Williamson, 2012 .

Testing the protective effect of a candidate small molecule in a Drosophila model of Amyotrophic Lateral Sclerosis (ALS)

A. Sousa, 2019 .

Instability of sputum molecular phenotypes in U-BIOPRED severe asthma

C. Auffray, P. Howarth, J. Corfield, 2020, European Respiratory Journal.

Type 2‐low asthma phenotypes by integration of sputum transcriptomics and serum proteomics

C. Auffray, M. Saqi, S. Dahlén, 2020, Allergy.

Sputum proteomic signature of gastro-oesophageal reflux in patients with severe asthma.

C. Auffray, B. Dimitrov, P. Howarth, 2019, Respiratory medicine.