C. Clayton

发表

Roles of triosephosphate isomerase and aerobic metabolism in Trypanosoma brucei.

Barbara M. Bakker, S. Helfert, A. Estévez, 2001, The Biochemical journal.

Effects of depletion and overexpression of the Trypanosoma brucei ribonuclease L inhibitor homologue.

Christine Clayton, Luis Quijada, A. Estévez, 2004, Molecular and biochemical parasitology.

The Genome of the Kinetoplastid Parasite, Leishmania major

Heather J Munden, B. Barrell, A. Goffeau, 2005, Science.

Post-transcriptional regulation of gene expression in trypanosomes and leishmanias.

C. Clayton, M. Shapira, 2007, Molecular and biochemical parasitology.

The miRNA and mRNA Signatures of Peripheral Blood Cells in Humans Infected with Trypanosoma brucei gambiense

J. Hoheisel, C. Clayton, S. Leong, 2013, PloS one.

University of Groningen The silicon trypanosome

Barbara M. Bakker, M. Girolami, R. Breitling, 2017 .

The silicon trypanosome

M. Girolami, R. Breitling, H. Westerhoff, 2010, Parasitology.

Regulation of gene expression in trypanosomatids: living with polycistronic transcription

C. Clayton, 2019, Open Biology.

Discovery of the Mechanism of Action of Novel Compounds That Target Unicellular Eukaryotic Parasites

C. Clayton, Daniela Begolo, 2016 .

Life without transcriptional control? From fly to man and back again

C. Clayton, Christine E. Clayton, 2002, The EMBO journal.

The Regulation of Trypanosome Gene Expression by RNA-Binding Proteins

Christine Clayton, C. Clayton, 2013, PLoS pathogens.

Ribose 5-Phosphate Isomerase B Knockdown Compromises Trypanosoma brucei Bloodstream Form Infectivity

C. Clayton, S. Macedo-Ribeiro, N. Roy, 2015, PLoS neglected tropical diseases.

Processing of a phosphoglycerate kinase reporter mRNA in Trypanosoma brucei is not coupled to transcription by RNA polymerase II.

C. Clayton, S. Haile, M. Cristodero, 2010, Molecular and biochemical parasitology.

3′ processing in protists

C. Clayton, S. Michaeli, 2011, Wiley interdisciplinary reviews. RNA.

Conservation of mitochondrial targeting sequence function in mitochondrial and hydrogenosomal proteins from the early-branching eukaryotes Crithidia, Trypanosoma and Trichomonas.

C. Clayton, Y. Stierhof, T. Häusler, 1997, European journal of cell biology.

The PARP promoter of Trypanosoma brucei is developmentally regulated in a chromosomal context.

C. Clayton, H. Hotz, J. Barry, 1996, Nucleic acids research.

Hierarchies of RNA-processing signals in a trypanosome surface antigen mRNA precursor

C. Clayton, H. Hotz, C. Hartmann, 1994 .

Protein trafficking in kinetoplastid protozoa

C. Clayton, T. Häusler, J. Blattner, 1995 .

Mechanisms of translation repression by the EIF4E1-4EIP cap-binding complex of Trypanosoma brucei: potential roles of the NOT complex and a terminal uridylyl transferase

C. Clayton, K. Marucha, Franz Falk, 2021, bioRxiv.

The suppressive cap-binding complex factor 4EIP is required for normal differentiation

C. Clayton, K. Marucha, M. Terrão, 2018, bioRxiv.

The suppressive cap-binding-complex factor 4EIP is required for normal differentiation

C. Clayton, M. Terrão, Elisha Mugo, 2018, bioRxiv.

Mitochondrial carrier family inventory of Trypanosoma brucei brucei: Identification, expression and subcellular localisation.

C. Clayton, F. Voncken, Claudia Colasante, 2009, Molecular and biochemical parasitology.

ADVANCES IN MICROBIAL SYSTEMS BIOLOGY

Barbara M. Bakker, Alejandro E Leroux, M. Girolami, 2014 .

Codon Usage in Trypanosomatids: The Bias of Expression.

C. Clayton, E. Erben, 2018, Trends in parasitology.

A Search for Trypanosoma brucei rhodesiense Diagnostic Antigens by Proteomic Screening and Targeted Cloning

C. Clayton, E. Matovu, F. Frank, 2010, PloS one.

Depletion of GIM5 Causes Cellular Fragility, a Decreased Glycosome Number, and Reduced Levels of Ether-linked Phospholipids in Trypanosomes*

C. Clayton, F. Voncken, A. Maier, 2003, Journal of Biological Chemistry.

The Trypanosoma brucei zinc finger protein ZC3H18 is involved in differentiation.

C. Clayton, Corinna Benz, J. Mulindwa, 2011, Molecular and biochemical parasitology.

Protein trafficking in kinetoplastid protozoa.

C. Clayton, T. Häusler, J. Blattner, 1995, Microbiological reviews.

The Cell Cycle Regulated Transcriptome of Trypanosoma brucei

C. Clayton, S. Archer, Diana Inchaustegui, 2011, PloS one.

Trypanosomes as a model to investigate mRNA decay pathways.

C. Clayton, S. Archer, M. Stewart, 2008, Methods in enzymology.

Functional analysis of Trypanosoma brucei PUF1.

J. Hoheisel, C. Clayton, V. Luu, 2006, Molecular and biochemical parasitology.

Elongation and clustering of glycosomes in Trypanosoma brucei overexpressing the glycosomal Pex11p

C. Clayton, A. Maier, E. Baumgart, 1998, The EMBO journal.

Blood signatures for second stage human African trypanosomiasis: a transcriptomic approach

C. Clayton, E. Matovu, J. Enyaru, 2019, BMC Medical Genomics.

Regulation of an amino acid transporter mRNA in Trypanosoma brucei.

C. Clayton, A. Robles, 2008, Molecular and biochemical parasitology.

The transcriptomes of Trypanosoma brucei Lister 427 and TREU927 bloodstream and procyclic trypomastigotes.

J. Hoheisel, C. Clayton, M. Schanné, 2005, Molecular and biochemical parasitology.

Post-Transcriptional Regulation of the Trypanosome Heat Shock Response by a Zinc Finger Protein

C. Clayton, Aditi Singh, Abeer A. Fadda, 2013, PLoS pathogens.

The procyclic acidic repetitive proteins of Trypanosoma brucei. Purification and post-translational modification.

C. Clayton, M. Mowatt, 1989, The Journal of biological chemistry.

Roles of a Trypanosoma brucei 5'->3' exoribonuclease homolog in mRNA degradation.

C. Clayton, S. Haile, Chi-Ho Li, 2006, RNA.

Substrate Specificity, Localization, and Essential Role of the Glutathione Peroxidase-type Tryparedoxin Peroxidases in Trypanosoma brucei*

C. Clayton, F. Voncken, R. Krauth-Siegel, 2005, Journal of Biological Chemistry.

Functional depletion of T- and B-memory cells and other lymphoid cell subpopulations-during trypanosomiasis.

C. Clayton, A. Corsini, B. Askonas, 1979, Immunology.

The exosomes of trypanosomes and other protists.

C. Clayton, A. Estévez, 2011, Advances in experimental medicine and biology.

Heat shock causes a decrease in polysomes and the appearance of stress granules in trypanosomes independently of eIF2α phosphorylation at Thr169

J. Hoheisel, C. Clayton, M. Carrington, 2008, Journal of Cell Science.

Control of mRNA degradation in trypanosomes.

C. Clayton, Corinna Benz, S. Archer, 2008, Biochemical Society transactions.

Functional analysis of a simian virus 40 super T-antigen

M. Lovett, P. Rigby, C. Clayton, 1982, Journal of virology.

Small Trypanosome RNA-Binding Proteins TbUBP1 and TbUBP2 Influence Expression of F-Box Protein mRNAs in Bloodstream Trypanosomes

J. Hoheisel, A. Frasch, C. Clayton, 2007, Eukaryotic Cell.

4E Interacting Protein as a Potential Novel Drug Target for Nucleoside Analogues in Trypanosoma brucei

C. Clayton, S. van Calenbergh, P. Takáč, 2021, Microorganisms.

Edinburgh Research Explorer The silicon trypanosome

Barbara M. Bakker, R. Breitling, H. Westerhoff, 2018 .

The roles of 3′-exoribonucleases and the exosome in trypanosome mRNA degradation

C. Clayton, Abeer A. Fadda, Dorothea Droll, 2013, RNA.

Characterization of the RNA binding protein RBP10 in Trypanosoma brucei

J. Hoheisel, C. Clayton, M. Stewart, 2011 .

The 3'-untranslated regions from the Trypanosoma brucei phosphoglycerate kinase-encoding genes mediate developmental regulation.

C. Clayton, J. Blattner, 1995, Gene.

Sequences and proteins that influence mRNA processing in Trypanosoma brucei: Evolutionary conservation of SR-domain and PTB protein functions

C. Clayton, D. Grimm, Albina Waithaka, 2022, bioRxiv.

The RNA helicase DHH1 is central to the correct expression of many developmentally regulated mRNAs in trypanosomes

J. Hoheisel, C. Clayton, M. Carrington, 2010, Journal of Cell Science.

Effect of multiple downstream splice sites on polyadenylation in Trypanosoma brucei.

C. Clayton, H. Hotz, C. Hartmann, 1998, Molecular and biochemical parasitology.

PARP gene expression: control at many levels.

C. Clayton, H. Hotz, S. Biebinger, 1998, Molecular and biochemical parasitology.

Post-transcriptional control of PARP gene expression.

C. Clayton, H. Hotz, 1996, Molecular and biochemical parasitology.

Post-transcriptional control of hsp70 mRNA in Trypanosoma brucei.

C. Clayton, T. Häusler, 1996, Molecular and biochemical parasitology.

Role of 3'-untranslated regions in the regulation of hexose transporter mRNAs in Trypanosoma brucei.

C. Clayton, H. Hotz, R. Fischer, 1995, Molecular and biochemical parasitology.

S0031182021000123jra 1..10

C. Clayton, Bin Liu, Diana Gil, 2021 .

Developmental regulation of a novel repetitive protein of Trypanosoma brucei

C. Clayton, M. Mowatt, Christine Clayton, 1987, Molecular and cellular biology.

Transcription of 'inactive' expression sites in African trypanosomes leads to expression of multiple transferrin receptor RNAs in bloodstream forms.

S. Melville, C. Clayton, D. Steverding, 1999, Molecular and biochemical parasitology.

Properties of single-step mutants of Syrian hamster cell lines resistant to N-(phosphonacetyl)-L-aspartate

G. Stark, C. Clayton, E. Giulotto, 1983, Molecular and cellular biology.

Structure and synthesis of a simian virus 40 super T-antigen

M. Lovett, P. Rigby, C. Clayton, 1982, Journal of virology.

Impaired dimerization and trafficking of ESAG6 lacking a glycosyl-phosphatidylinositol anchor.

S. Helfert, C. Clayton, D. Steverding, 2003, Molecular and biochemical parasitology.

Testing promoter activity in the trypanosome genome: isolation of a metacyclic-type VSG promoter, and unexpected insights into RNA polymerase II transcription.

C. Clayton, S. Graham, C. Hartmann, 1998, Experimental parasitology.

Characterisation of the growth and differentiation in vivo and in vitro-of bloodstream-form Trypanosoma brucei strain TREU 927.

C. Clayton, C. Turner, K. Matthews, 2001, Molecular and biochemical parasitology.

Proteins and lipids of glycosomal membranes from Leishmania tarentolae and Trypanosoma brucei

C. Clayton, F. Voncken, A. Tielens, 2013, F1000Research.

Proteins and lipids of glycosomal membranes from Leishmania tarentolae and Trypanosoma brucei

C. Clayton, F. Voncken, A. Tielens, 2013, F1000Research.

The role of the 5'-3' exoribonuclease XRNA in transcriptome-wide mRNA degradation.

C. Clayton, Abeer A. Fadda, Theresa Manful, 2011, RNA.

Depletion of 14-3-3 proteins in bloodstream-form Trypanosoma brucei inhibits variant surface glycoprotein recycling.

C. Clayton, M. Engstler, Corinna Benz, 2010, International journal for parasitology.

The F-box protein CFB2 is required for cytokinesis of bloodstream-form Trypanosoma brucei.

C. Clayton, Corinna Benz, 2007, Molecular and biochemical parasitology.

The coatomer of Trypanosoma brucei.

C. Clayton, M. Carrington, A. Maier, 2001, Molecular and biochemical parasitology.

The cell biology of disease.

C. Clayton, 1995, Trends in microbiology.

Variation of tandem repeats in the developmentally regulated procyclic acidic repetitive proteins of Trypanosoma brucei

C. Clayton, M. Mowatt, G. S. Wisdom, 1989, Molecular and cellular biology.

A domino effect in drug action: from metabolic assault towards parasite differentiation

Barbara M. Bakker, Christine Clayton, Jildau Bouwman, 2011, Molecular microbiology.

Stress susceptibility in Trypanosoma brucei lacking the RNA-binding protein ZC3H30

C. Clayton, Chaitali Chakraborty, 2018, PLoS neglected tropical diseases.

A plasmid shuttle vector bearing an rRNA promoter is extrachromosomally maintained in Crithidia fasciculata.

C. Clayton, S. Biebinger, 1996, Experimental parasitology.

A possible role for the 3'-untranslated region in developmental regulation in Trypanosoma brucei.

D. Sherman, C. Clayton, G. Cross, 1993, Molecular and biochemical parasitology.

Distinct mRNA and protein interactomes highlight functional differentiation of major eIF4F-like complexes from Trypanosoma brucei

Mark C. Field, C. Clayton, Christian R S Reis, 2022, Frontiers in Molecular Biosciences.

Roles and interactions of the specialized initiation factors EIF4E2, EIF4E5 and EIF4E6 in Trypanosoma brucei: EIF4E2 maintains the abundances of S-phase mRNAs

C. Clayton, Franz Falk, Albina Waithaka, 2022, bioRxiv.

Several different sequences are implicated in bloodstream-form-specific gene expression in Trypanosoma brucei

B. Liu, C. Clayton, L. Reichert, 2021, bioRxiv.

Roles of the Pumilio domain protein PUF3 in Trypanosoma brucei growth and differentiation

C. Clayton, K. Marucha, 2020, Parasitology.

The zinc finger proteins ZC3H20 and ZC3H21 stabilise mRNAs encoding membrane proteins and mitochondrial proteins in insect‐form Trypanosoma brucei

C. Clayton, B. Liu, K. Marucha, 2019, Molecular microbiology.

Expression of normal levels of the Pumilio domain protein PUF3 is required for optimal growth of Trypanosoma brucei

C. Clayton, K. Marucha, 2019, bioRxiv.

Interactions of CAF1-NOT complex components from Trypanosoma brucei

J. Hoheisel, C. Clayton, S. Lueong, 2017 .

The CAF1-NOT complex of trypanosomes

C. Clayton, Chaitali Chakraborty, E. Erben, 2014, Front. Genet..

Analysis of stage-specific gene expression in the bloodstream and the procyclic form of Trypanosoma brucei using a genomic DNA-microarray.

J. Hoheisel, C. Clayton, N. El-Sayed, 2002, Molecular and biochemical parasitology.

Mechanisms of developmental regulation in Trypanosoma brucei: a polypyrimidine tract in the 3'-untranslated region of a surface protein mRNA affects RNA abundance and translation.

C. Clayton, H. Hotz, C. Hartmann, 1997, Nucleic acids research.

Transcriptome analysis of differentiating trypanosomes reveals the existence of multiple post-transcriptional regulons

J. Hoheisel, C. Clayton, K. Fellenberg, 2009, BMC Genomics.

Import of fructose bisphosphate aldolase into the glycosomes of Trypanosoma brucei

C. Clayton, 1987, The Journal of cell biology.

Regulation of a transmembrane protein gene family by the small RNA-binding proteins TbUBP1 and TbUBP2.

C. Clayton, C. Hartmann, 2008, Molecular and biochemical parasitology.

Regulating a Post-Transcriptional Regulator: Protein Phosphorylation, Degradation and Translational Blockage in Control of the Trypanosome Stress-Response RNA-Binding Protein ZC3H11

C. Clayton, I. Minia, 2016, PLoS pathogens.

Clinically relevant benzoxaboroles inhibit mRNA processing in Trypanosoma brucei

C. Clayton, Albina Waithaka, 2022, BMC research notes.

Gel shift experiments with fragments of the Trypanosoma brucei RNA-binding protein RBP10

C. Clayton, Binghai Liu, 2022, BMC research notes.

The trypanosome Variant Surface Glycoprotein mRNA is stabilized by an essential unconventional RNA-binding protein

C. Clayton, F. Egler, E. Erben, 2020 .

Control and Regulation of Gene Expression

Barbara M. Bakker, H. Westerhoff, C. Clayton, 2008, Journal of Biological Chemistry.

Genetic nomenclature for Trypanosoma and Leishmania.

W Degrave, N. Biteau, F. Opperdoes, 1998, Molecular and biochemical parasitology.

The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing

Isabel M. Vincent, M. Barrett, C. Clayton, 2018, bioRxiv.

The role of Trypanosoma brucei MRPA in melarsoprol susceptibility.

V. Alibu, C. Clayton, F. Voncken, 2006, Molecular and biochemical parasitology.

Overexpression of the putative thiol conjugate transporter TbMRPA causes melarsoprol resistance in Trypanosoma brucei

C. Clayton, R. Krauth-Siegel, S. Shahi, 2002, Molecular microbiology.

Expression of the human RNA-binding protein HuR in Trypanosoma brucei increases the abundance of mRNAs containing AU-rich regulatory elements.

C. Ben-Dov, C. Clayton, L. Quijada, 2002, Nucleic acids research.

Vectors for inducible expression of toxic gene products in bloodstream and procyclic Trypanosoma brucei.

C. Clayton, S. Biebinger, L. Wirtz, 1997, Molecular and biochemical parasitology.

Inducible gene expression in trypanosomes mediated by a prokaryotic repressor.

C. Clayton, E. Wirtz, Elizabeth Wirtz, 1995, Science.

Tests of heterologous promoters and intergenic regions in Leishmania major.

C. Clayton, S. Beverley, S. Ha, 2000, Molecular and biochemical parasitology.

Genetic manipulation of kinetoplastida.

C. Clayton, 1999, Parasitology today.

A novel essential RNA-binding protein complex in Trypanosoma brucei

C. Clayton, E. Erben, Kevin Leiss, 2020, bioRxiv.

Suppressor cells and loss of B-cell potential in mice infected with Trypanosoma brucei.

C. Clayton, A. Corsini, B. Askonas, 1977, Clinical and experimental immunology.

A fragment of the SV40 large T-antigen gene transforms

M. Lovett, P. Rigby, C. Clayton, 1982, Nature.

RNA interference in trypanosomes transfected with sense and antisense plasmids.

C. Clayton, L. Quijada, M. Drozdz, 2002, Molecular and biochemical parasitology.

Cloning and characterization of the integrated viral DNA from three lines of SV40-transformed mouse cells

P. Rigby, C. Clayton, 1981, Cell.

Trypanosoma brucei PUF9 Regulates mRNAs for Proteins Involved in Replicative Processes over the Cell Cycle

C. Clayton, V. Luu, S. Archer, 2009, PLoS pathogens.

Compartmentation of phosphoglycerate kinase in Trypanosoma brucei plays a critical role in parasite energy metabolism.

S. Helfert, P. Michels, C. Clayton, 1998, Proceedings of the National Academy of Sciences of the United States of America.

The promoter for a variant surface glycoprotein gene expression site in Trypanosoma brucei.

M. Ouellette, C. Clayton, P. Borst, 1990, The EMBO journal.

Trypanosome CNOT10 is essential for the integrity of the NOT deadenylase complex and for degradation of many mRNAs.

C. Clayton, G. Stoecklin, Sahil Sharma, 2013, Nucleic acids research.

Toxoplasma gondii catalase: are there peroxisomes in toxoplasma?

C. Clayton, D. Soldati, D Soldati, 2000, Journal of cell science.

Glycosome assembly in trypanosomes: variations in the acceptable degeneracy of a COOH-terminal microbody targeting signal

C. Clayton, S. Subramani, T. Prospero, 1992, The Journal of cell biology.

Polymorphism in the procyclic acidic repetitive protein gene family of Trypanosoma brucei

C. Clayton, M. Mowatt, 1988 .

Polymorphism in the procyclic acidic repetitive protein gene family of Trypanosoma brucei.

C. Clayton, M. Mowatt, 1988, Molecular and cellular biology.

Polymorphism intheProcyclic Acidic Repetitive Protein Gene FamilyofTrypanosoma brucei

C. Clayton, M. Mowatt, 1988 .

Import of a DHFR hybrid protein into glycosomes in vivo is not inhibited by the folate-analogue aminopterin

C. Clayton, Y. Stierhof, E. Wirtz, 1996, The Journal of cell biology.

Phosphorylation of fructose bisphosphate aldolase in Trypanosoma brucei.

C. Clayton, J. Fox, 1989, Molecular and biochemical parasitology.

An essential dimeric membrane protein of trypanosome glycosomes

C. Clayton, F. Voncken, P. Lorenz, 2001, Molecular microbiology.

Expression of the RNA recognition motif protein RBP10 promotes a bloodstream‐form transcript pattern in Trypanosoma brucei

C. Clayton, Bhaskar Anand Jha, Martin Wurst, 2012, Molecular microbiology.

The antioxidant systems in Toxoplasma gondii and the role of cytosolic catalase in defence against oxidative injury

C. Clayton, D. Soldati, D. Schlüter, 2005, Molecular microbiology.

The antioxidant systems in Toxoplasma gondii and the role of cytosolic catalase in defence against oxidative injury

C. Clayton, D. Soldati, D. Schlüter, 2003 .

Purification of Messenger Ribonucleoprotein Particles via a Tagged Nascent Polypeptide

C. Clayton, Diana P. Inchaustegui Gil, 2016, PloS one.

Variations in the organization of repetitive DNA sequences in the genomes of Plasmodium falciparum clones.

C. Clayton, G. Cross, W. Trager, 1985, Molecular and biochemical parasitology.

Identification of core components of the exon junction complex in trypanosomes.

C. Clayton, M. Levin, Natalia Bercovich, 2009, Molecular and biochemical parasitology.

RNA-Binding Domain Proteins in Kinetoplastids: a Comparative Analysis

A. Frasch, C. Clayton, Javier G. De Gaudenzi, 2005, Eukaryotic Cell.

The exosome of Trypanosoma brucei

C. Clayton, T. Kempf, A. Estévez, 2001, The EMBO journal.

The Trypanosoma brucei RNA-binding protein DRBD18 ensures correct mRNA trans splicing and polyadenylation patterns

C. Clayton, Tania Bishola Tshitenge, 2022, bioRxiv.

The RNA-binding protein DRBD18 regulates processing and export of the mRNA encoding Trypanosoma brucei RNA-binding protein 10

C. Clayton, Bin Liu, T. B. Tshitenge, 2021, bioRxiv.

Gene expression in Kinetoplastids.

C. Clayton, 2016, Current opinion in microbiology.

Is There a Classical Nonsense-Mediated Decay Pathway in Trypanosomes?

C. Clayton, M. Carrington, Diana Inchaustegui, 2011, PloS one.

Examination of the mode of action of the almiramide family of natural products against the kinetoplastid parasite Trypanosoma brucei.

Roger G. Linington, C. Clayton, G. Knudsen, 2013, Journal of natural products.

The Roles of Intersubunit Interactions in Exosome Stability*

Ben Lehner, C. Clayton, C. Sanderson, 2003, Journal of Biological Chemistry.

The EIF4E1-4EIP cap-binding complex of Trypanosoma brucei interacts with the terminal uridylyl transferase TUT3

C. Clayton, Franz Falk, Kevin Kamanyi Marucha, 2021, PloS one.

Metabolic selection of a homologous recombination-mediated gene loss protects Trypanosoma brucei from ROS production by glycosomal fumarate reductase

C. Clayton, M. Biran, N. Plazolles, 2021, The Journal of biological chemistry.

Metabolic selection of a homologous recombination mediated loss of glycosomal fumarate reductase in Trypanosoma brucei

C. Clayton, M. Biran, N. Plazolles, 2020, bioRxiv.

The role of the zinc finger protein ZC3H32 in bloodstream-form Trypanosoma brucei

C. Clayton, M. Terrão, C. Klein, 2017, PloS one.

Integrative analysis of the Trypanosoma brucei gene expression cascade predicts differential regulation of mRNA processing and unusual control of ribosomal protein expression

P. Myler, C. Clayton, M. Parsons, 2016, BMC Genomics.

Transcriptome-wide analysis of trypanosome mRNA decay reveals complex degradation kinetics and suggests a role for co-transcriptional degradation in determining mRNA levels

Barbara M. Bakker, C. Clayton, K. Matthews, 2014, Molecular microbiology.

A Genome-Wide Tethering Screen Reveals Novel Potential Post-Transcriptional Regulators in Trypanosoma brucei

J. Hoheisel, C. Clayton, S. Lueong, 2014, PLoS pathogens.

Depletion of the Trypanosome Pumilio Domain Protein PUF2 or of Some Other Essential Proteins Causes Transcriptome Changes Related to Coding Region Length

C. Clayton, Abeer A. Fadda, Bhaskar Anand Jha, 2014, Eukaryotic Cell.

Trypanosome MKT1 and the RNA-binding protein ZC3H11: interactions and potential roles in post-transcriptional regulatory networks

C. Clayton, Aditi Singh, Abeer A. Fadda, 2014, Nucleic acids research.

Depletion of Trypanosome CTR9 Leads to Gene Expression Defects

C. Clayton, Abeer A. Fadda, M. Maleš, 2012, PloS one.

The role of deadenylation in the degradation of unstable mRNAs in trypanosomes

C. Clayton, M. Stewart, Mhairi L. Stewart, 2009, Nucleic acids research.

Transcriptomes of Trypanosoma brucei rhodesiense from sleeping sickness patients, rodents and culture: Effects of strain, growth conditions and RNA preparation methods

C. Clayton, K. Matthews, E. Matovu, 2018, PLoS neglected tropical diseases.

Transcriptomes of newly-isolated Trypanosoma brucei rhodesiense reveal hundreds of mRNAs that are co-regulated with stumpy-form markers

C. Clayton, E. Matovu, J. Enyaru, 2015, BMC Genomics.

Murine trypanosomiasis: cellular proliferation and functional depletion in the blood, peritoneum, and spleen related to changes in bone marrow stem cells.

C. Clayton, M. Selkirk, B. Askonas, 1980, Infection and immunity.

A doubly inducible system for RNA interference and rapid RNAi plasmid construction in Trypanosoma brucei.

Christine Clayton, David Horn, V. Alibu, 2005, Molecular and biochemical parasitology.

Methods to Determine the Transcriptomes of Trypanosomes in Mixtures with Mammalian Cells: The Effects of Parasite Purification and Selective cDNA Amplification

C. Clayton, J. Enyaru, Abeer A. Fadda, 2014, PLoS neglected tropical diseases.

Polysomes of Trypanosoma brucei: Association with Initiation Factors and RNA-Binding Proteins

C. Clayton, M. Terrão, C. Klein, 2015, PloS one.

Networks of gene expression regulation in Trypanosoma brucei.

C. Clayton, Christine Clayton, 2014, Molecular and biochemical parasitology.

Developmental regulation of nuclear gene expression in Trypanosoma brucei.

C. Clayton, 1992, Progress in nucleic acid research and molecular biology.

Post-transcriptional regulation

C. Clayton, 2003 .

Characterization and Developmentally Regulated Localization of the Mitochondrial Carrier Protein Homologue MCP6 from Trypanosoma brucei

V. Alibu, C. Clayton, F. Voncken, 2006, Eukaryotic Cell.

Trypanosoma brucei infection in nude mice: B lymphocyte function is suppressed in the absence of T lymphocytes

C. Clayton, B. Askonas, B. Ogilvie, 1979, Parasite immunology.

A culture system for in vitro studies of immunity to Trypanosoma (Herpetosoma) musculi.

C. Clayton, 1980, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Membrane fractions of trypanosomes mimic the immunosuppressive and mitogenic effects of living parasites on the host

C. Clayton, D. Sacks, B. Askonas, 1979, Parasite immunology.

Trypanosoma brucei: influence of host strain and parasite antigenic type on infections in mice.

C. Clayton, 1978, Experimental parasitology.

Trypanosomiasis leads to extensive proliferation of B, T and null cells in spleen and bone marrow.

C. Clayton, B. Askonas, G. Roelants, 1978, Clinical and experimental immunology.

The PARP and rRNA promoters of Trypanosoma brucei are composed of dissimilar sequence elements that are functionally interchangeable

C. Clayton, L. Janz, Lennart Janz, 1994, Molecular and cellular biology.

Factors that bind to RNA polymerase I promoter sequences of Trypanosoma brucei.

C. Clayton, M. Hug, L. Janz, 1994, Molecular and biochemical parasitology.

Transfection of Leishmania and Trypanosoma brucei by electroporation.

C. Clayton, S. Beverley, Stephen M. Beverley, 1993, Methods in molecular biology.

Transcription of the procyclic acidic repetitive protein genes of Trypanosoma brucei

D. Sherman, C. Clayton, M. Mowatt, 1990, Molecular and cellular biology.

The genes encoding fructose bisphosphate aldolase in Trypanosoma brucei are interspersed with unrelated genes.

D. Sherman, P. Michels, C. Clayton, 1990, Nucleic acids research.

Structure and regulated expression of genes encoding fructose biphosphate aldolase in Trypanosoma brucei.

C. Clayton, 1985, The EMBO journal.

Hierarchies of RNA-processing signals in a trypanosome surface antigen mRNA precursor

C. Clayton, H. Hotz, M Hug, 1994, Molecular and cellular biology.

Trypanosome MTR4 is involved in rRNA processing

C. Clayton, M. Cristodero, 2007, Nucleic acids research.

A Role for Caf1 in Mrna Deadenylation and Decay in Trypanosomes and Human Cells

C. Clayton, M. Carrington, J. Luther, 2022 .

A role for Caf1 in mRNA deadenylation and decay in trypanosomes and human cells

C. Clayton, M. Carrington, J. Luther, 2008, Nucleic acids research.

Degradation of the unstable EP1 mRNA in Trypanosoma brucei involves initial destruction of the 3'-untranslated region.

C. Clayton, H. Irmer, 2001, Nucleic acids research.

Repetitive elements in parasitic protozoa

C. Clayton, 2010, BMC Biology.

A role for the exosome in the in vivo degradation of unstable mRNAs.

C. Clayton, S. Haile, A. Estévez, 2003, RNA.

The RNA-associated proteins MKT1 and MKT1L form alternative PBP1-containing complexes in Trypanosoma brucei

C. Clayton, B. Liu, K. Marucha, 2020, The Journal of Biological Chemistry.

Essential PBP1-associated proteins of Trypanosoma brucei

C. Clayton, B. Liu, K. Marucha, 2020, bioRxiv.

The Leishmania tarentolae exosome: purification and structural analysis by electron microscopy.

C. Clayton, B. Böttcher, K. Scheffzek, 2008, Molecular and biochemical parasitology.

Interactions of the Trypanosoma brucei brucei zinc-finger-domain protein ZC3H28

C. Clayton, Tania Bishola, 2021, bioRxiv.

The role of Tb ZC 3 H 11 in the trypanosomal heat shock response

C. Clayton, 2012 .

SUMOylation in Trypanosoma brucei

C. Clayton, Dorothea Droll, C. Klein, 2013, PeerJ.

Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress

A. Fairlamb, W. Schwarz, C. Clayton, 2000, Molecular microbiology.

Functional insights from a surface antigen mRNA-bound proteome

C. Clayton, F. Egler, E. Erben, 2021, eLife.

Silencing of the thioredoxin gene in Trypanosoma brucei brucei.

C. Clayton, R. Krauth-Siegel, Armin Schmidt, 2002, Molecular and biochemical parasitology.

The trypanosome Pumilio-domain protein PUF7 associates with a nuclear cyclophilin and is involved in ribosomal RNA maturation

C. Clayton, K. Matthews, S. Archer, 2010, FEBS letters.

Metabolic compartmentation in African trypanosomes.

P. Michels, C. Clayton, 1996, Parasitology today.

An unambiguous nomenclature for the major surface glycoproteins of the procyclic form of Trypanosoma brucei.

C. Clayton, I. Roditi, Christine Clayton, 1999, Molecular and biochemical parasitology.

S0031182021000123jra 1186..1195

C. Clayton, Bin Liu, E. Erben, 2021 .

Expression of the RNA-binding protein RBP10 promotes the bloodstream-form differentiation state in Trypanosoma brucei

C. Clayton, Elisha Mugo, 2017, PLoS pathogens.

Why do we need standard genetic nomenclature for parasite genes and gene products?

C. Clayton, 2000, Acta tropica.

Structure of a regulatory 3' untranslated region from Trypanosoma brucei.

C. Clayton, M. Drozdz, 1999, RNA.

C O M M E N TA R Y Open Access

C. Clayton, 2010 .

Messenger RNA processing sites in Trypanosoma brucei.

Daniel Nilsson, Christine Clayton, Björn Andersson, 2005, Molecular and biochemical parasitology.

Anatomy of the parp gene promoter of Trypanosoma brucei.

C. Clayton, M. Hug, M. Hug, 1991, The EMBO journal.

An RNAi screen of the RRM-domain proteins of Trypanosoma brucei.

J. Hoheisel, C. Clayton, L. Quijada, 2009, Molecular and biochemical parasitology.

Down-regulating gene expression by RNA interference in Trypanosoma brucei.

Mark C. Field, V. Alibu, C. Clayton, 2005, Methods in molecular biology.

In vitro culture of freshly isolated Trypanosoma brucei brucei bloodstream forms results in gene copy-number changes

C. Clayton, E. Matovu, K. Marucha, 2021, bioRxiv.

The zinc finger proteins ZC3H20 and ZC3H21 stabilise mRNAs encoding membrane proteins and mitochondrial proteins in insect-form Trypanosoma brucei

Bin Liu, C. Clayton, B. Liu, 2019, bioRxiv.

Conversion of procyclic-form Trypanosoma brucei to the bloodstream form by transient expression of RBP10.

C. Clayton, Elisha Mugo, F. Egler, 2017, Molecular and biochemical parasitology.

mRNA Turnover in Trypanosomes

C. Clayton, 2012 .

Knockdown of Asparagine Synthetase A Renders Trypanosoma brucei Auxotrophic to Asparagine

C. Clayton, N. Roy, N. Santarém, 2013, PLoS neglected tropical diseases.

The endoplasmic reticulum-associated mRNA-binding proteins ERBP1 and ERBP2 interact in bloodstream-form Trypanosoma brucei

C. Clayton, E. Erben, Kevin Leiss, 2019, bioRxiv.

Regulated expression of glycosomal phosphoglycerate kinase in Trypanosoma brucei.

C. Clayton, F. Voncken, Corinna Benz, 2007, Molecular and biochemical parasitology.

Drug Target Identification Using a Trypanosome Overexpression Library

C. Clayton, Daniela Begolo, E. Erben, 2014, Antimicrobial Agents and Chemotherapy.

The RNA-binding protein RBP10 controls a regulatory cascade that defines bloodstream-form trypanosome identity

C. Clayton, Elisha Mugo, 2016, bioRxiv.

mRNA degradation-exoribonucleases and the exosome in trypanosome ′ The roles of 3 Material Supplemental

C. Clayton, Dorothea Droll, Valentin Färber, 2013 .

Compartmentation of enzymes in a microbody, the glycosome, is essential in Trypanosoma brucei.

C. Clayton, L. Quijada, C. Guerra-Giraldez, 2002, Journal of cell science.

A potential role for a novel ZC3H5 complex in regulating mRNA translation in Trypanosoma brucei

C. Clayton, E. Erben, Kevin Leiss, 2020, The Journal of Biological Chemistry.

Translation Regulation and RNA Granule Formation after Heat Shock of Procyclic Form Trypanosoma brucei: Many Heat-Induced mRNAs Are also Increased during Differentiation to Mammalian-Infective Forms

C. Clayton, M. Terrão, I. Minia, 2016, PLoS neglected tropical diseases.

TbMP81 is required for RNA editing in Trypanosoma brucei

Christine Clayton, Reza Salavati, Kenneth Stuart, 2002, The EMBO journal.

Composition of the editing complex of Trypanosoma brucei.

A. Schnaufer, K. Stuart, C. Clayton, 2002, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

The silicon trypanosome: a test case of iterative model extension in systems biology.

Mark Girolami, Rainer Breitling, Dong-Hyun Kim, 2014, Advances in microbial physiology.

Proteins Associated with SF3a60 in T. brucei

C. Clayton, D. Masiga, M. Levin, 2014, PloS one.

The Trypanosome Pumilio Domain Protein PUF5

C. Clayton, S. Archer, Bhaskar Anand Jha, 2013, PloS one.

The subcellular localisation of trypanosome RRP6 and its association with the exosome.

C. Clayton, S. Haile, M. Cristodero, 2007, Molecular and biochemical parasitology.

Gene expression mediated by bacteriophage T3 and T7 RNA polymerases in transgenic trypanosomes.

C. Clayton, E. Wirtz, C. Hartmann, 1994, Nucleic acids research.

Novel Observations Concerning Differentiation of Bloodstream-Form Trypanosomes to the Form That Is Adapted for Growth in Tsetse Flies

C. Clayton, 2018, mSphere.

Polysome Profiling and Metabolic Labeling Methods to Measure Translation in Trypanosoma brucei.

C. Clayton, Kathrin Bajak, 2020, Methods in molecular biology.

The expression level determines the surface distribution of the transferrin receptor in Trypanosoma brucei

C. Clayton, P. Borst, J. Calafat, 2002, Molecular microbiology.

Recognition of a peroxisomal tripeptide entry signal by the glycosomes of Trypanosoma brucei.

C. Clayton, K. Fung, 1991, Molecular and biochemical parasitology.

Insights into the functions and RNA binding of Trypanosoma brucei ZC3H22, RBP9 and DRBD7

C. Clayton, Bin Liu, E. Erben, 2021, Parasitology.

Transcription oftheProcyclic Acidic Repetitive Protein Genesof Trypanosoma brucei

D. Sherman, C. Clayton, S. Vijayasarathy, 1990 .

The Trypanosoma brucei CCCH zinc finger proteins ZC3H12 and ZC3H13.

Christine Clayton, C. Clayton, M. Stewart, 2012, Molecular and biochemical parasitology.

Most proteins, including fructose bisphosphate aldolase, are stable in the procyclic trypomastigote form of Trypanosoma brucei.

C. Clayton, 1988, Molecular and biochemical parasitology.

Binding of coatomer by the PEX11 C‐terminus is not required for function

C. Clayton, A. Maier, M. Bremser, 2000, FEBS letters.

Using transfection to study gene expression in trypanosomes.

D. Sherman, C. Clayton, G. Cross, 1990, Biochemical Society transactions.

The procyclic surface protein of Trypanosoma brucei.

C. Clayton, C. Wang, M. Mowatt, 1991 .

The exosomes of trypanosomes and other protists.

C. Clayton, A. Estévez, 2010, Advances in experimental medicine and biology.

DRBD1 is the Trypanosoma brucei homologue of the spliceosome-associated protein 49.

C. Clayton, M. Cristodero, Theresa Manful, 2009, Molecular and biochemical parasitology.

Post-Transcriptional Regulation of the Trypanosome Heat Shock Response by a Zinc Finger Protein

C. Clayton, Aditi Singh, Abeer A. Fadda, 2013, PLoS pathogens.

A role for Caf 1 in mRNA deadenylation and decay in trypanosomes and human cells

C. Clayton, M. Carrington, J. Luther, 2008 .

Transcriptome Remodeling in Trypanosoma cruzi and Human Cells during Intracellular Infection

C. Clayton, M. Temanni, N. El-Sayed, 2016, PLoS pathogens.

High-Throughput Sequencing for Trypanosome Transcriptome Characterization.

C. Clayton, J. Mulindwa, Kevin Leiss, 2020, Methods in molecular biology.

A Role for Caf1 in Mrna Deadenylation and Decay in Trypanosomes and Human Cells

C. Clayton, M. Carrington, J. Luther, 2022 .

Trypanosome Cnot10 Is Essential for the Integrity of the Not Deadenylase Complex and for Degradation of Many Mrnas

C. Clayton, G. Stoecklin, Sahil Sharma, 2022 .

Corrigendum to "Functional analysis of Trypanosoma brucei PUF1" [Mol. Biochem. Parasitol. 150 (2006) 340–349]

J. Hoheisel, C. Clayton, V. Luu, 2010 .

Gene expression changes after heat shock of procyclic-form Trypanosoma brucei suggest that stress has a role in differentiation to mammalian-infective forms

C. Clayton, M. Terrão, I. Minia, 2016, bioRxiv.

Faculty Opinions recommendation of Genome organization and DNA accessibility control antigenic variation in trypanosomes.

C. Clayton, 2018, Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature.