Lanlan Shen

发表

Silencing of bidirectional promoters by DNA methylation in tumorigenesis.

J. Issa, J. Shu, J. Jelinek, 2006, Cancer research.

DNA methylation changes after 5-aza-2'-deoxycytidine therapy in patients with leukemia.

J. Issa, Lanlan Shen, A. Rashid, 2006, Cancer research.

IGFBP7 is a p53-responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype.

Hiroyuki Yamamoto, Hirofumi Akashi, Kohzoh Imai, 2010, Carcinogenesis.

Comparison and quantitative verification of mapping algorithms for whole-genome bisulfite sequencing

A. Milosavljevic, C. Coarfa, R. Harris, 2014, Nucleic acids research.

HLTF gene silencing in human colon cancer

C. Plass, J. Minna, J. Issa, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation

D. Gold, J. Issa, Lanlan Shen, 2008, Nature Genetics.

Regulation of AURKC expression by CpG island methylation in human cancer cells

Kaori Sasai, H. Katayama, S. Sen, 2015, Tumor Biology.

Genome-Wide Profiling of DNA Methylation Reveals a Class of Normally Methylated CpG Island Promoters

Li Zhang, Yi Guo, J. Issa, 2007, PLoS genetics.

High-throughput methylation profiling by MCA coupled to CpG island microarray.

Pearlly S Yan, J. Issa, Lanlan Shen, 2007, Genome research.

Histone deacetylase inhibition elicits an evolutionarily conserved self-renewal program in embryonic stem cells.

Paul Pavlidis, Muneesh Tewari, Zhijun Duan, 2009, Cell stem cell.

Correlation between CpG methylation profiles and hormone receptor status in breast cancers

Xin Hu, Sijin Wen, Yinhua Yu, 2007, Breast Cancer Research.

Rare CpG island methylator phenotype in ulcerative colitis-associated neoplasias.

J. Issa, Lanlan Shen, Suna Wang, 2007, Gastroenterology.

Epigenetic-Genetic Interactions in the APC/WNT, RAS/RAF, and P53 Pathways in Colorectal Carcinoma

Jeffrey S. Morris, Tsung-Teh Wu, Suet Yi Leung, 2008, Clinical Cancer Research.

Chromatin immunoprecipitation microarrays for identification of genes silenced by histone H3 lysine 9 methylation.

Tim Hui-Ming Huang, Pearlly S Yan, J. Issa, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Study of Environmental Enteropathy and Malnutrition (SEEM) in Pakistan: protocols for biopsy based biomarker discovery and validation

Michael J. Barratt, Donald E. Brown, C. Moskaluk, 2019, BMC Pediatrics.

Comprehensive Promoter Methylation Analysis of Genes on 5q31.1 in MDS and AML.

J. Issa, J. Jelinek, Lanlan Shen, 2005 .

Induction of hypomethylation and molecular response after decitabine therapy in patients with chronic myelomonocytic leukemia.

J. Issa, J. Jelinek, Lanlan Shen, 2008, Blood.

Repetitive elements and enforced transcriptional repression co-operate to enhance DNA methylation spreading into a promoter CpG-island

J. Issa, J. Shu, Lanlan Shen, 2012, Nucleic acids research.

Identification of Novel Tumor Markers in Prostate, Colon and Breast Cancer by Unbiased Methylation Profiling

J. Issa, J. Jelinek, Lanlan Shen, 2008, PLoS ONE.

Predict multicategory causes of death in lung cancer patients using clinicopathologic factors.

Lanlan Shen, Yong Lin, Lanjing Zhang, 2020, Computers in biology and medicine.

Identification of Novel Tumor Markers in Prostate, Colon and Breast Cancer by Unbiased Methylation Profiling

Michael Ittmann, Yinhua Yu, J. Issa, 2008, PloS one.

The Competition between DNA Methylation and Demethylation is Associated with Transcription Regulation and Tumorigenesis

J. Li, Lanlan Shen, Jiejun Shi, 2021 .

On the meaning of the word 'epimutation': a comment.

Lanlan Shen, R. Waterland, Da-Hai Yu, 2015, Trends in genetics : TIG.

Lack of p21CIP1 DNA methylation in acute lymphocytic leukemia

J. Issa, Lanlan Shen, Y. Kondo, 2002 .

P14 methylation in human colon cancer is associated with microsatellite instability and wild-type p53.

J. Issa, Lanlan Shen, A. Rashid, 2003, Gastroenterology.

Downregulation of Histone H3 Lysine 9 Methyltransferase G9a Induces Centrosome Disruption and Chromosome Instability in Cancer Cells

J. Issa, Lanlan Shen, Y. Kondo, 2008, PloS one.

Season of Conception in Rural Gambia Affects DNA Methylation at Putative Human Metastable Epialleles

A. Prentice, R. Harris, M. Travisano, 2010, PLoS genetics.

CpG island methylation profiling in human melanoma cell lines

J. Issa, J. Jelinek, Lanlan Shen, 2009, Melanoma research.

Drug sensitivity prediction by CpG island methylation profile in the NCI-60 cancer cell line panel.

Yi Guo, J. Issa, Lanlan Shen, 2007, Cancer research.

Sensitive and specific detection of early gastric cancer with DNA methylation analysis of gastric washes.

Yi Guo, M. Toyota, J. Issa, 2009, Gastroenterology.

Foxa1 Functions as a Pioneer Transcription Factor at Transposable Elements to Activate Afp during Differentiation of Embryonic Stem Cells*

Lanlan Shen, M. Barton, S. Duncan, 2010, The Journal of Biological Chemistry.

Decitabine improves patient outcomes in myelodysplastic syndromes

John M Bennett, J. Issa, Lanlan Shen, 2006, Cancer.

Tumour vasculature: On the verge of collapse

Gary L Rosner, David S Alberts, Stanley R Hamilton, 2005, Nature Reviews Cancer.

Epigenome - A mediator for host-microbiome crosstalk.

Lanlan Shen, E. Claud, M. Pammi, 2021, Seminars in perinatology.

DNA methylation and environmental exposures in human hepatocellular carcinoma.

Nita Ahuja, Minoru Toyota, N. Ahuja, 2002, Journal of the National Cancer Institute.

Targeted p16(Ink4a) epimutation causes tumorigenesis and reduces survival in mice.

Lanlan Shen, R. Waterland, Yongtao Guan, 2014, The Journal of clinical investigation.

The concurrence of DNA methylation and demethylation is associated with transcription regulation

Lanlan Shen, Wei Li, Jiejun Shi, 2021, Nature Communications.

Characterization of microRNAs involved in embryonic stem cell states.

Hannele Ruohola-Baker, Julie Mathieu, Angelique Nelson, 2010, Stem cells and development.

CDC42 inhibition suppresses progression of incipient intestinal tumors.

Lanlan Shen, F. Walker, M. Taketo, 2014, Cancer research.

Understanding the development of human bladder cancer by using a whole-organ genomic mapping strategy

K. Baggerly, D. Yoon, S. Scherer, 2008, Laboratory Investigation.

Delta DNMT3B variants regulate DNA methylation in a promoter-specific manner.

J. Issa, J. Jelinek, Lanlan Shen, 2007, Cancer research.

Developmentally Programmed 3′ CpG Island Methylation Confers Tissue- and Cell-Type-Specific Transcriptional Activation

Manasi Gadkari, Robert A. Waterland, C. Ware, 2013, Molecular and Cellular Biology.

LINE-1 Hypomethylation in Cancer Is Highly Variable and Inversely Correlated with Microsatellite Instability

J. Issa, J. Jelinek, Lanlan Shen, 2007, PloS one.

Genome architecture marked by retrotransposons modulates predisposition to DNA methylation in cancer.

B. Czerniak, J. Issa, J. Jelinek, 2010, Genome research.

Epigenomic profiling indicates a role for DNA methylation in early postnatal liver development.

Lanlan Shen, Jiexin Zhang, R. Waterland, 2009, Human molecular genetics.

Effects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia

J. Issa, J. Jelinek, Lanlan Shen, 2012, Epigenetics.

Maternal folate genes and aberrant DNA hypermethylation in pediatric acute lymphoblastic leukemia

Lanlan Shen, S. Tsavachidis, M. Bondy, 2018, PloS one.

J. Issa, J. Jelinek, Lanlan Shen, 2007, Clinical Cancer Research.

Epigenetic profiles distinguish malignant pleural mesothelioma from lung adenocarcinoma.

M. Toyota, J. Issa, Lanlan Shen, 2009, Cancer research.

Enhanced inflammation and attenuated tumor suppressor pathways are associated with oncogene‐induced lung tumors in aged mice

L. Donehower, Lanlan Shen, Neha Parikh, 2017, Aging cell.

Epigenetic maturation in colonic mucosa continues beyond infancy in mice.

Lanlan Shen, C. Smith, R. Waterland, 2010, Human molecular genetics.

Hypomethylation of long interspersed nuclear element-1 in hepatocellular carcinomas

J. Issa, Lanlan Shen, A. Rashid, 2009, Modern Pathology.

DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes.

D. Berry, E. Estey, Yi Guo, 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Critical Role of Histone Methylation in Tumor Suppressor Gene Silencing in Colorectal Cancer

J. Issa, Lanlan Shen, Y. Kondo, 2003, Molecular and Cellular Biology.

RIL, a LIM gene on 5q31, is silenced by methylation in cancer and sensitizes cancer cells to apoptosis.

E. Estey, J. Issa, Lanlan Shen, 2007, Cancer research.

Widespread and Tissue Specific Age-related Dna Methylation Material Supplemental Related Content a Hallmark of Cancer Age-dependent Dna Methylation of Genes That Are Suppressed in Stem Cells Is

Nianxiang Zhang, Shoudan Liang, L. Donehower, 2022 .

Variable DNA methylation patterns associated with progression of disease in hepatocellular carcinomas.

J. Issa, Lanlan Shen, Jiexin Zhang, 2008, Carcinogenesis.

Methods of DNA methylation analysis

Lanlan Shen, R. Waterland, 2007, Current opinion in clinical nutrition and metabolic care.

changes in mice Widespread and tissue specific age-related DNA methylation Material Supplemental

L. Donehower, Nianxiang Zhang, J. Issa, 2010 .

An Sp1/Sp3 Binding Polymorphism Confers Methylation Protection

Yi Guo, J. Issa, Lanlan Shen, 2008, PLoS genetics.

Concordant DNA Methylation in Synchronous Colorectal Carcinomas

J. Issa, J. Jelinek, Lanlan Shen, 2009, Cancer Prevention Research.

Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer

Minoru Toyota, Stanley R Hamilton, Yi Guo, 2007, Proceedings of the National Academy of Sciences.

DNA Methylation Profiles of Primary Colorectal Carcinoma and Matched Liver Metastasis

Yi Guo, J. Issa, J. Jelinek, 2011, PloS one.

Characteristic methylation profile in CpG island methylator phenotype‐negative distal colorectal cancers

Lanlan Shen, K. Matsuo, Y. Yatabe, 2010, International journal of cancer.

Association between DNA Methylation and Shortened Survival in Patients with Advanced Colorectal Cancer Treated with 5-Fluorouracil–Based Chemotherapy

P. Catalano, A. Benson, J. Issa, 2007, Clinical Cancer Research.

CIMP, at last.

M. Toyota, Lanlan Shen, J. Issa, 2005, Gastroenterology.

Alterations of DNA methylation and histone modifications contribute to gene silencing in hepatocellular carcinomas

Hideaki Kato, Ryuzo Ueda, Yoshiki Mizuno, 2007, Hepatology research : the official journal of the Japan Society of Hepatology.

Vascular endothelial growth factor receptor-1 activation mediates epithelial to mesenchymal transition in human pancreatic carcinoma cells.

L. Ellis, Wenbiao Liu, F. Fan, 2006, Cancer research.

Frequent Alteration of MLL3 Frameshift Mutations in Microsatellite Deficient Colorectal Cancer

M. Toyota, J. Issa, J. Jelinek, 2011, PloS one.

Postnatal epigenetic regulation of intestinal stem cells requires DNA methylation and is guided by the microbiome

Lanlan Shen, L. Bry, Rui Chen, 2015, Genome Biology.

Association between Folate Levels and CpG Island Hypermethylation in Normal Colorectal Mucosa

Elizabeth L. Barry, J. Issa, Lanlan Shen, 2010, Cancer Prevention Research.

Optimizing annealing temperature overcomes bias in bisulfite PCR methylation analysis.

J. Issa, Lanlan Shen, Xinli Chen, 2007, BioTechniques.

Forerunner genes contiguous to RB1 contribute to the development of in situ neoplasia

K. Baggerly, S. Scherer, Xifeng Wu, 2007, Proceedings of the National Academy of Sciences.

Major epigenetic development distinguishing neuronal and non-neuronal cells occurs postnatally in the murine hypothalamus.

Lanlan Shen, R. Waterland, Wenjuan Zhang, 2014, Human molecular genetics.

Aberrant CpG island methylation in acute myeloid leukemia is accentuated at relapse.

J. Issa, J. Jelinek, Lanlan Shen, 2008, Blood.

Aberrant DNA methylation of p57KIP2 identifies a cell-cycle regulatory pathway with prognostic impact in adult acute lymphocytic leukemia.

Kohzoh Imai, Minoru Toyota, Guillermo Garcia-Manero, 2003, Blood.

Global DNA Hypomethylation (LINE-1) in the Normal Colon and Lifestyle Characteristics and Dietary and Genetic Factors

J. Issa, Lanlan Shen, J. Baron, 2009, Cancer Epidemiology Biomarkers & Prevention.

Epigenetic inactivation of EGFR by CpG island hypermethylation in cancer

J. Issa, Lanlan Shen, M. Estecio, 2006, Cancer biology & therapy.

15‐Lipoxygenase‐1 transcriptional silencing by DNA methyltransferase‐1 independently of DNA methylation

S. Lippman, J. Issa, Lanlan Shen, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Discovery of benzo[d]isothiazole derivatives as novel scaffold inhibitors targeting the programmed cell death-1/programmed cell death-ligand 1 (PD-1/PD-L1) interaction through "ring fusion" strategy.

Lanlan Shen, M. Cheng, Yinli Gao, 2022, Bioorganic chemistry.

Classify multicategory outcome in patients with lung adenocarcinoma using clinical, transcriptomic and clinico-transcriptomic data: machine learning versus multinomial models.

Lanlan Shen, He Wang, Lanjing Zhang, 2020, American journal of cancer research.

Postnatal epigenetic regulation of intestinal stem cells requires DNA methylation and is guided by the microbiome

R. Chen, Lanlan Shen, L. Bry, 2015, Genome Biology.

Phenotype of Microsatellite-Stable Colorectal Carcinomas With CpG Island Methylation

P. Catalano, L. Chirieac, J. Issa, 2005, The American journal of surgical pathology.

CpG Island Methylation Is a Poor Prognostic Factors in Myelodysplastic Syndrome Patients and Is Reversed by Decitabine Therapy-Results of a Phase III Randomized Study.

D. Berry, J. Issa, J. Jelinek, 2005 .

Drug discovery targeting p21-activated kinase 4 (PAK4): a patent review

Lanlan Shen, Jian Wang, M. Cheng, 2021, Expert opinion on therapeutic patents.

Murine Methyl Donor Deficiency Impairs Early Growth in Association with Dysmorphic Small Intestinal Crypts and Reduced Gut Microbial Community Diversity

Lanlan Shen, R. Ley, S. Moore, 2018, Current developments in nutrition.

Lack of p21(CIP1) DNA methylation in acute lymphocytic leukemia.

J. Issa, Lanlan Shen, Y. Kondo, 2002, Blood.

Functional characterization of age-dependent p16 epimutation reveals biological drivers and therapeutic targets for colorectal cancer

C. Creighton, Lanlan Shen, S. Jung, 2023, Journal of Experimental & Clinical Cancer Research.

CpG island methylation in colorectal adenomas.

Jeffrey S. Morris, J. Issa, Lanlan Shen, 2001, The American journal of pathology.

Aberrant methylation of the Cyclooxygenase 2 CpG island in colorectal tumors.

M. Toyota, M. Ohe-Toyota, J. Issa, 2000, Cancer research.

Epigenetics in colorectal cancer.

J. Issa, Lanlan Shen, J. Issa, 2002, Current opinion in gastroenterology.

Correlation between DNA methylation and pathological changes in human hepatocellular carcinoma.

Lanlan Shen, Jiamei Yang, J. Yang, 1998, Hepato-gastroenterology.

Cell-autonomous activation of Hedgehog signaling inhibits brown adipose tissue development

Lanlan Shen, Q. Tong, Eric J. Jaehnig, 2015, Proceedings of the National Academy of Sciences.

Murine Methyl Donor Deficiency Impairs Early Growth in Association with Dysmorphic Small Intestinal Crypts and Reduced Gut Microbial Community Diversity

Lanlan Shen, R. Ley, S. Moore, 2018, Current developments in nutrition.

Characterization of microRNAs involved in embryonic stem cell states.

Daniel G. Miller, M. Cleary, Angelique M. Nelson, 2010, Stem cells and development.

Aberrant DNA methylation associated with silencing BNIP3 gene expression in haematopoietic tumours

M. Toyota, J. Issa, Lanlan Shen, 2005, British Journal of Cancer.