D. Davies

发表

Cigarette Smoke Causes Caspase-Independent Apoptosis of Bronchial Epithelial Cells from Asthmatic Donors

P. Howarth, F. Bucchieri, A. Marino Gammazza, 2015, PloS one.

Three-dimensional characterization of fibroblast foci in idiopathic pulmonary fibrosis

Mark G. Jones, A. Nicholson, D. Hansell, 2016, JCI insight.

Spiruchostatin A inhibits proliferation and differentiation of fibroblasts from patients with pulmonary fibrosis.

A. Ganesan, D. Davies, K. O'Reilly, 2012, American journal of respiratory cell and molecular biology.

Label-Free Differential Leukocyte Counts Using a Microfabricated, Single-Cell Impedance Spectrometer

D. Davies, D. Holmes, J. Holloway, 2007, 2007 IEEE Sensors.

Role of deficient type III interferon-lambda production in asthma exacerbations.

S. Johnston, S. Holgate, D. Davies, 2006, Nature medicine.

Leukocyte analysis and differentiation using high speed microfluidic single cell impedance cytometry.

Christian H. Reccius, D. Davies, D. Holmes, 2009, Lab on a chip.

Tumour necrosis factor (TNFalpha) as a novel therapeutic target in symptomatic corticosteroid dependent asthma.

P. Howarth, S. Holgate, D. Davies, 2005, Thorax.

β-Catenin/T-cell factor-mediated transcription is modulated by cell density in human bronchial epithelial cells

Robert M. Powell, Stephen T. Holgate, John W. Holloway, 2005 .

TNF-α-mediated bronchial barrier disruption and regulation by src-family kinase activation.

P. Howarth, S. Holgate, D. Davies, 2013, The Journal of allergy and clinical immunology.

Paracrine SPARC signaling dysregulates alveolar epithelial barrier integrity and function in lung fibrosis

Mark G. Jones, P. Skipp, D. Davies, 2020, Cell Death Discovery.

Effect of bronchoconstriction on airway remodeling in asthma.

P. Howarth, Susan J Wilson, S. Holgate, 2011, The New England journal of medicine.

Osteopontin is expressed and functional in human eosinophils

P. Howarth, D. Ribatti, D. Davies, 2010, Allergy.

Ligand-induced translocation of epidermal growth factor receptor to the nucleus of NR6/HER fibroblasts is serum dependent.

S. J. Holt, D. Davies, C. Inman, 1995, Experimental cell research.

Allergenic proteases cleave the chemokine CX3CL1 directly from the surface of airway epithelium and augment the effect of rhinovirus

P. Howarth, S. Holgate, D. Davies, 2017, Mucosal Immunology.

Invited Lecture: Activation of the Epithelial Mesenchymal Trophic Unit in the Pathogenesis of Asthma

P. Howarth, Susan J Wilson, S. Holgate, 2001, International Archives of Allergy and Immunology.

Epidermal growth factor induced tyrosine phosphorylation of nuclear proteins associated with translocation of epidermal growth factor receptor into the nucleus.

S. J. Holt, D. Davies, C. Inman, 1994, Biochemical pharmacology.

Targeting the networks that underpin contiguous immunity in asthma and chronic obstructive pulmonary disease.

D. Davies, S. Dower, M. Whyte, 2007, American journal of respiratory and critical care medicine.

Medium-term culture of normal human oral mucosa: a novel three-dimensional model to study the effectiveness of drugs administration.

F. Bucchieri, A. Marino Gammazza, A. Pitruzzella, 2012, Current pharmaceutical design.

IL-4 Receptor α Is an Important Modulator of IL-4 and IL-13 Receptor Binding: Implications for the Development of Therapeutic Targets1

S. Holgate, D. Davies, J. Holloway, 2006, The Journal of Immunology.

Understanding the pathophysiology of severe asthma to generate new therapeutic opportunities.

P. Howarth, Susan J Wilson, S. Holgate, 2006, The Journal of allergy and clinical immunology.

The soluble form of a disintegrin and metalloprotease 33 promotes angiogenesis: implications for airway remodeling in asthma.

David I. Wilson, P. Howarth, D. Ribatti, 2008, The Journal of allergy and clinical immunology.

Contribution of the Transforming Growth Factor B-loop -Sheet to Binding and Activation of the Epidermal Growth Factor Receptor (*)

D. Davies, S. G. Chamberlin, D. Drummond, 1995, The Journal of Biological Chemistry.

Regulation of a disintegrin and metalloprotease-33 expression by transforming growth factor-β.

P. Howarth, S. Holgate, D. Davies, 2012, American journal of respiratory cell and molecular biology.

Epithelial injury and repair in airways diseases.

D. Davies, C. Grainge, 2013, Chest.

Expression of c-erbB receptors and ligands in the bronchial epithelium of asthmatic subjects.

P. Howarth, S. Holgate, D. Davies, 2002, The Journal of allergy and clinical immunology.

Cooperative Effects of Th2 Cytokines and Allergen on Normal and Asthmatic Bronchial Epithelial Cells1

Susan J Wilson, R. Djukanović, F. Bucchieri, 2002, The Journal of Immunology.

The contribution of transforming growth factor-β and epidermal growth factor signalling to airway remodelling in chronic asthma

S. Holgate, D. Davies, C. Boxall, 2006, European Respiratory Journal.

Engineering multi-layered tissue constructs using acoustic levitation

D. Davies, P. Glynne-Jones, M. Hill, 2019, Scientific Reports.

Local genetic and environmental factors in asthma disease pathogenesis: chronicity and persistence mechanisms

P. Howarth, S. Holgate, D. Davies, 2007, European Respiratory Journal.

Identification of lipocalin and apolipoprotein A1 as biomarkers of chronic obstructive pulmonary disease.

P. Howarth, Dave Singh, B. Nicholas, 2010, American journal of respiratory and critical care medicine.

A unified model of c-erbB receptor homo- and heterodimerisation.

D. Davies, S. G. Chamberlin, 1998, Biochimica et biophysica acta.

Transforming Growth Factor-Beta Promotes Rhinovirus Replication in Bronchial Epithelial Cells by Suppressing the Innate Immune Response

P. Howarth, S. Holgate, D. Davies, 2012, PloS one.

Epithelial-mesenchymal communication in the pathogenesis of chronic asthma.

Susan J Wilson, F. Bucchieri, S. Holgate, 2004, Proceedings of the American Thoracic Society.

Induction of the epidermal growth factor receptor and its ligands in nasal epithelium by ozone.

P. Howarth, S. Holgate, D. Davies, 2004, The Journal of allergy and clinical immunology.

Contribution of host-derived growth factors to in vivo growth of a transplantable murine mammary carcinoma.

D. Davies, S. Warnes, P. Alexander, 1994, British Journal of Cancer.

Cysteinyl leukotrienes synergize with growth factors to induce proliferation of human bronchial fibroblasts.

S. Holgate, D. Davies, E. Healy, 2007, The Journal of allergy and clinical immunology.

The role of ADAM33 in the pathogenesis of asthma

S. Holgate, D. Davies, T. Keith, 2004, Springer Seminars in Immunopathology.

The role of a soluble TNFα receptor fusion protein (etanercept) in corticosteroid refractory asthma: a double blind, randomised, placebo controlled trial

S. Holgate, D. Davies, R. Polosa, 2008, Thorax.

Altered Epithelial Gene Expression in Peripheral Airways of Severe Asthma

P. Howarth, D. Davies, A. Singhania, 2017, PloS one.

Effects Of IL-13 And IL-17 On Fibroblasts Derived From The Proximal And Distal Airways

D. Davies, J. Warner, A. Andrews, 2011, ATS 2011.

Oxidative stress–induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease

A. Bittner, M. Polkey, I. Adcock, 2015, The Journal of allergy and clinical immunology.

ADAM33 expression in asthmatic airways and human embryonic lungs.

David I. Wilson, P. Howarth, Susan J Wilson, 2005, American journal of respiratory and critical care medicine.

A disintegrin and metalloprotease 33 expression in asthmatic airways and human embryonic lungs

David I. Wilson, P. Howarth, Susan J Wilson, 2005 .

Superresolved polarization-enhanced second-harmonic generation for direct imaging of nanoscale changes in collagen architecture

Mark G. Jones, O. Muskens, D. Davies, 2021, Optica.

Mechanisms of airway epithelial damage: epithelial-mesenchymal interactions in the pathogenesis of asthma

P. Howarth, S. Holgate, D. Davies, 2003, European Respiratory Journal.

Epithelial barrier function and immunity in asthma.

D. Davies, 2014, Annals of the American Thoracic Society.

Temporal Monitoring of Differentiated Human Airway Epithelial Cells Using Microfluidics

D. Davies, J. Collins, T. Millar, 2015, PloS one.

Double-stranded RNA induces disproportionate expression of thymic stromal lymphopoietin versus interferon-β in bronchial epithelial cells from donors with asthma

P. Howarth, S. Holgate, D. Davies, 2010, Thorax.

Role of tumor necrosis factor alpha in asthma.

S. Holgate, D. Davies, K. S. Babu, 2004, Immunology and allergy clinics of North America.

Epigenetic mechanisms silence a disintegrin and metalloprotease 33 expression in bronchial epithelial cells.

P. Howarth, S. Holgate, D. Davies, 2008, The Journal of allergy and clinical immunology.

Mast cells are permissive for rhinovirus replication: potential implications for asthma exacerbations

D. Davies, E. Swindle, C. Akoto, 2017, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

IFN-γ–induced protein 10 is a novel biomarker of rhinovirus-induced asthma exacerbations

S. Johnston, F. Bucchieri, S. Holgate, 2007, Journal of Allergy and Clinical Immunology.

Altered protein tyrosine phosphorylation in asthmatic bronchial epithelium

P. Howarth, T. Sandström, S. Holgate, 2005, European Respiratory Journal.

The role of the epidermal growth factor receptor in sustaining neutrophil inflammation in severe asthma

R. Djukanović, S. Holgate, D. Davies, 2003, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Asthmatic bronchial epithelium is more susceptible to oxidant-induced apoptosis.

P. Howarth, Susan J Wilson, R. Djukanović, 2002, American journal of respiratory cell and molecular biology.

The role of CD28-B7 costimulation in allergen-induced cytokine release by bronchial mucosa from patients with moderately severe asthma.

R. Djukanović, S. Holgate, D. Davies, 2001, The Journal of allergy and clinical immunology.

The contribution of interleukin (IL)-4 and IL-13 to the epithelial-mesenchymal trophic unit in asthma.

R. Djukanović, F. Bucchieri, S. Holgate, 2001, American journal of respiratory cell and molecular biology.

Enhancement of neutrophil function by the bronchial epithelium stimulated by epidermal growth factor

R. Djukanović, D. Davies, G. Seumois, 2008, European Respiratory Journal.

Enhancement of neutrophil function by the bronchial epithelium stimulated by EGF

D. Davies, G. Seumois, L. Lau, 2007 .

Super-resolved polarisation-enhanced second harmonic generation for direct imaging of nanoscale changes in collagen architecture

Mark G. Jones, O. Muskens, D. Davies, 2020, bioRxiv.

On the generation of allergic airway diseases: from GM-CSF to Kyoto.

M. Jordana, S. Holgate, D. Davies, 2002, Trends in immunology.

Analysis of novel disease-related genes in bronchial asthma.

K. Arai, S. Holgate, D. Davies, 2002, Cytokine.

Mechanical Strain Causes Adaptive Change in Bronchial Fibroblasts Enhancing Profibrotic and Inflammatory Responses

P. Howarth, F. Bucchieri, S. Holgate, 2016, PloS one.

Neutrophil influx and interleukin-8 release after segmental allergen or saline challenge in asthmatics.

P. Howarth, S. Holgate, D. Davies, 1995, International archives of allergy and immunology.

Leukocyte recruitment after local endobronchial allergen challenge in asthma. Relationship to procedure and to airway interleukin-8 release.

P. Howarth, S. Holgate, D. Davies, 1996, American journal of respiratory and critical care medicine.

Eosinophil recruitment following allergen challenge is associated with the release of the chemokine RANTES into asthmatic airways.

S. Holgate, D. Davies, J. Schröder, 1996, Journal of immunology.

The genetics of asthma: ADAM33 as an example of a susceptibility gene.

S. Holgate, D. Davies, H. Haitchi, 2006, Proceedings of the American Thoracic Society.

Contribution of eotaxin-1 to eosinophil chemotactic activity of moderate and severe asthmatic sputum.

R. Djukanović, D. Davies, R. Louis, 2004, American journal of respiratory and critical care medicine.

Artificial airways for the study of respiratory disease

D. Davies, E. Swindle, 2011, Expert review of respiratory medicine.

A disintegrin and metalloprotease (ADAM) 33 protein in patients with pulmonary sarcoidosis

Mark G. Jones, P. Howarth, D. Davies, 2012, Respirology.

Induction of a disintegrin and metalloprotease 33 during embryonic lung development and the influence of IL-13 or maternal allergy.

David I. Wilson, F. Bucchieri, S. Holgate, 2009, The Journal of allergy and clinical immunology.

The bronchial epithelium in chronic and severe asthma

D. Davies, 2001, Current allergy and asthma reports.

The innate antiviral response upregulates IL-13 receptor α2 in bronchial fibroblasts.

S. Holgate, D. Davies, N. Bedke, 2013, The Journal of allergy and clinical immunology.

Sputum IL-6 concentrations in severe asthma and its relationship with FEV1

S. Holgate, D. Davies, P. Vijayanand, 2010, Thorax.

Viral Stimuli Trigger Exaggerated Thymic Stromal Lymphopoietin Expression by Chronic Obstructive Pulmonary Disease Epithelium: Role of Endosomal TLR3 and Cytosolic RIG-I-Like Helicases

D. Davies, G. Westergren-Thorsson, O. Hallgren, 2011, Journal of Innate Immunity.

In vitro models of bronchialepithelial cell infection

S. Holgate, D. Davies, P. Wark, 2007 .

The role of the airway epithelium and its interaction with environmental factors in asthma pathogenesis.

P. Howarth, G. Roberts, S. Holgate, 2009, Proceedings of the American Thoracic Society.

Asthma: the importance of epithelial mesenchymal communication in pathogenesis. Inflammation and the airway epithelium in asthma.

S. Holgate, D. Davies, 2002, The international journal of biochemistry & cell biology.

Safety and efficacy of inhaled nebulised interferon beta-1a (SNG001) for treatment of SARS-CoV-2 infection: a randomised, double-blind, placebo-controlled, phase 2 trial

Dave Singh, R. Djukanović, S. Holgate, 2020, The Lancet Respiratory Medicine.

The epidermal growth factor receptor and its ligand family: their potential role in repair and remodelling in asthma.

S. Holgate, D. Davies, R. Polosa, 1999, Allergy.

Measurement of eotaxin (CCL11) in induced sputum supernatants: validation and detection in asthma.

R. Djukanović, D. Davies, G. Dent, 2004, The Journal of allergy and clinical immunology.

Contribution of Bronchial Fibroblasts to the Antiviral Response in Asthma1

S. Holgate, D. Davies, H. Haitchi, 2009, The Journal of Immunology.

IL-13 receptor α 2: A regulator of IL-13 and IL-4 signal transduction in primary human fibroblasts

F. Bucchieri, S. Holgate, D. Davies, 2006 .

Barrier Disrupting Effects of Alternaria Alternata Extract on Bronchial Epithelium from Asthmatic Donors

P. Howarth, S. Holgate, D. Davies, 2013, PloS one.

Bronchial epithelium as a key regulator of airway allergen sensitization and remodeling in asthma.

S. Holgate, D. Davies, P. Lackie, 2000, American journal of respiratory and critical care medicine.

Expression of c-erbB receptors and ligands in human bronchial mucosa.

S. Holgate, D. Davies, P. Lackie, 1999, American journal of respiratory cell and molecular biology.

The chemokines: their potential role in allergic inflammation

D. Davies, L. Teran, 1996, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Poster Presentation

D. G. Kim, H. Gurbuz, N. Apaydın, 2022, Surgical and Radiologic Anatomy.

Epithelial Cells Allergen on Normal and Asthmatic Bronchial Cooperative Effects of Th2 Cytokines and

Susan J Wilson, R. Djukanović, F. Bucchieri, 2002 .

IL-1α mediates cellular cross-talk in the airway epithelial mesenchymal trophic unit

P. Howarth, D. Davies, C. Grainge, 2016, Tissue barriers.

The role of eosinophil major basic protein in angiogenesis

D. Ribatti, D. Davies, F. Levi-Schaffer, 2009, Allergy.

The bronchial epithelium: translating gene and environment interactions in asthma

D. Davies, 2001, Current opinion in allergy and clinical immunology.

Establishment of a pulmonary epithelial barrier on biodegradable poly-L-lactic-acid membranes

F. Bucchieri, D. Davies, V. Brucato, 2019, PloS one.

Modulation of Human Airway Barrier Functions during Burkholderia thailandensis and Francisella tularensis Infection Running Title: Airway Barrier Functions during Bacterial Infections

D. Davies, R. E. Bell, R. Read, 2016, Pathogens.

Differential roles of IL-16 and CD28/B7 costimulation in the generation of T-lymphocyte chemotactic activity in the bronchial mucosa of mild and moderate asthmatic individuals.

R. Djukanović, S. Holgate, D. Davies, 2002, The Journal of allergy and clinical immunology.

Particle and Fibre Toxicology Diesel Exhaust Increases Egfr and Phosphorylated C-terminal Tyr 1173 in the Bronchial Epithelium

Susan J Wilson, T. Sandström, S. Holgate, 2022 .

Characterization of CBE1, a ciliated cell-associated gene induced during mucociliary differentiation

David I. Wilson, S. Holgate, D. Davies, 2004 .

Chronological expression of Ciliated Bronchial Epithelium 1 during pulmonary development

F. Bucchieri, S. Holgate, G. Zummo, 2009, European Respiratory Journal.

Induction of anchorage-independent growth by amphiregulin.

D. Davies, S. G. Chamberlin, R. Adam, 1996, Growth factors.

Pollen exposure weakens innate defense against respiratory viruses

C. Akdis, D. Davies, A. Neumann, 2019, Allergy.

Identification of neutrophil chemotactie factors in bronchoalveolar lavage fluid of asthmatic patients

R. Djukanović, S. Holgate, D. Davies, 1997, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

S128 Soluble ADAM33 Causes Airway Remodelling To Promote Allergic Airway Inflammation

D. Davies, J. Whitsett, Elizabeth R. Davies, 2015 .

The bronchial epithelium in asthma--much more than a passive barrier.

S. Holgate, D. Davies, I. Kimber, 2001, Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace.

A method for the generation of large numbers of dendritic cells from CD34+ hematopoietic stem cells from cord blood

G. Roberts, S. Holgate, D. Davies, 2019, Journal of immunological methods.

Effects of anthralin and hypericin on growth factor signalling and cell proliferation in vitro.

D. Davies, A. Richter, 1995, Biochemical pharmacology.

Cellular localization of interleukin 13 receptor alpha2 in human primary bronchial epithelial cells and fibroblasts.

S. Holgate, D. Davies, J. Holloway, 2008, Journal of investigational allergology & clinical immunology.

Airway remodeling in asthma: new insights.

S. Holgate, D. Davies, S. Puddicombe, 2003, The Journal of allergy and clinical immunology.

The splicing and fate of ADAM33 transcripts in primary human airways fibroblasts.

S. Holgate, D. Davies, J. Holloway, 2004, American journal of respiratory cell and molecular biology.

Autophagy inhibition-mediated epithelial–mesenchymal transition augments local myofibroblast differentiation in pulmonary fibrosis

Mark G. Jones, D. Davies, D. Hancock, 2019, Cell Death & Disease.

Enhanced upregulation of smooth muscle related transcripts by TGFβ2 in asthmatic (myo) fibroblasts

S. Holgate, D. Davies, H. Haitchi, 2006, Thorax.

Inhibition of Pim1 kinase reduces viral replication in primary bronchial epithelial cells

P. Howarth, M. Nawijn, D. Davies, 2015, European Respiratory Journal.

Expression of c-erbB receptors and ligands in human nasal epithelium.

P. Howarth, S. Holgate, D. Davies, 2000, The Journal of allergy and clinical immunology.

The Severe Heterogeneous Asthma Research collaboration, Patient-centred (SHARP) ERS Clinical Research Collaboration: a new dawn in asthma research

G. Canonica, I. Adcock, K. Chung, 2018, European Respiratory Journal.

human embryonic lungs.

David I. Wilson, P. Howarth, Susan J Wilson, 2005 .

Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus

S. Johnston, F. Bucchieri, S. Holgate, 2005, The Journal of experimental medicine.

Molecular mechanisms of the synergy between cysteinyl-leukotrienes and receptor tyrosine kinase growth factors on human bronchial fibroblast proliferation

S. Holgate, D. Davies, A. Sampson, 2006, European Respiratory Review.

The effect of inhaled IFN-β on worsening of asthma symptoms caused by viral infections. A randomized trial.

N. Thomson, S. Johnston, Dave Singh, 2014, American journal of respiratory and critical care medicine.

Resistin‐like molecule‐β is induced following bronchoconstriction of asthmatic airways

P. Howarth, J. Ward, D. Davies, 2012, Respirology.

Cytoplasmic tail of IL-13Ralpha2 regulates IL-4 signal transduction.

S. Holgate, D. Davies, J. Holloway, 2009, Biochemical Society transactions.

Effect of IL-13 receptor alpha2 levels on the biological activity of IL-13 variant R110Q.

F. Bucchieri, S. Holgate, D. Davies, 2007, The Journal of allergy and clinical immunology.

Increased expression of p21(waf) cyclin-dependent kinase inhibitor in asthmatic bronchial epithelium.

P. Howarth, Susan J Wilson, R. Djukanović, 2003, American journal of respiratory cell and molecular biology.

Asthmatic and normal respiratory epithelial cells respond differently to mechanical apical stress.

P. Howarth, D. Davies, L. Lau, 2014, American journal of respiratory and critical care medicine.

Genetics of Asthma

S. Holgate, D. Davies, H. Haitchi, 1993 .

Biocompatibility of poly(2-alkyl-2-oxazoline) brush surfaces for adherent lung cell lines.

D. Davies, P. Glynne-Jones, M. Hill, 2015, Biomaterials.

Soluble tumor necrosis factor alpha (TNF-alpha) receptor (Enbrel) as an effective therapeutic strategy in chronic severe asthma*

P. Howarth, S. Holgate, D. Davies, 2003 .

Regulation of ectodomain shedding of ADAM33 in vitro and in vivo

D. Davies, Elizabeth R. Davies, H. Haitchi, 2019, The Journal of allergy and clinical immunology.

Low molecular weight components of pollen alter bronchial epithelial barrier functions

D. Davies, C. Traidl‐Hoffmann, C. Blume, 2015, Tissue barriers.

Defective epithelial barrier function in asthma.

P. Howarth, R. Djukanović, S. Holgate, 2011, The Journal of allergy and clinical immunology.

Urinary epidermal growth factor (hEGF) levels in patients with carcinomas of the breast, colon and rectum.

D. Davies, J. Sweetenham, S. Warnes, 1990, British Journal of Cancer.

Synthesis of fragments of transforming growth factor alpha incorporating exo-2-Azabicyclo[2,2,1]heptane-3-carboxylic acids as proline substitutes

D. Davies, S. G. Chamberlin, N. Richards, 1995 .

Structural studies on bioactive compounds. 23. Synthesis of polyhydroxylated 2-phenylbenzothiazoles and a comparison of their cytotoxicities and pharmacological properties with genistein and quercetin.

D. Davies, M. Stevens, P. Alexander, 1994, Journal of medicinal chemistry.

Deconvolution of RNA-Seq Analysis of Hyperbaric Oxygen-Treated Mice Lungs Reveals Mesenchymal Cell Subtype Changes

Mark G. Jones, D. Davies, R. Ewing, 2020, International journal of molecular sciences.

A synthesis of 18-O-methyl mycalamide B

Justin K Davis, D. Davies, P. Kocieňski, 1996 .

The in vitro biological activities of synthetic 18-O-methyl mycalamide B, 10-epi-18-O-methyl mycalamide B and pederin.

D. Davies, P. Kocieňski, P. Raubo, 1997, Anti-cancer drug design.

Upregulation of epithelial metallothioneins by metal-rich ultrafine particulate matter from an underground railway.

D. Davies, F. Cassee, G. Packham, 2020, Metallomics : integrated biometal science.

Medium-term culture of primary oral squamous cell carcinoma in a three- dimensional model: effects on cell survival following topical 5-fluororacile delivery by drug-loaded matrix tablets.

F. Bucchieri, A. Marino Gammazza, A. Pitruzzella, 2012, Current pharmaceutical design.

Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology.

Sangeeta Khare, Carsten Kneuer, Uwe Marx, 2015, ALTEX.

Involvement of the epidermal growth factor receptor in epithelial repair in asthma

P. Howarth, S. Holgate, D. Davies, 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Long Term Culture of the A549 Cancer Cell Line Promotes Multilamellar Body Formation and Differentiation towards an Alveolar Type II Pneumocyte Phenotype

D. Davies, J. Collins, J. Cooper, 2016, PloS one.

Autocrine ligands for the epidermal growth factor receptor mediate interleukin-8 release from bronchial epithelial cells in response to cigarette smoke.

R. Djukanović, S. Holgate, D. Davies, 2002, American journal of respiratory cell and molecular biology.

Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis

Mark G. Jones, D. Davies, N. Kaminski, 2021, bioRxiv.

EGF-Induced Bronchial Epithelial Cells Drive Neutrophil Chemotactic and Anti-Apoptotic Activity in Asthma

P. Dorinsky, R. Djukanović, D. Davies, 2013, PloS one.

Differential effects of EGF and amphiregulin on adhesion molecule expression and migration of colon carcinoma cells.

D. Davies, N. Solic, Donna E. Davies, 1997, Experimental cell research.

A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations

Thomas Blicher, David Torrents, Adnan Custovic, 2013, Nature Genetics.

Epithelial-mesenchymal interactions in the pathogenesis of asthma

P. Howarth, S. Holgate, D. Davies, 2003 .

Regarding epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux

R. Djukanović, D. Davies, J. Perotin, 2019, European Respiratory Journal.

Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life

David I. Wilson, Jeffrey A. Whitsett, Stephen T. Holgate, 2016, JCI insight.

Epithelial stress and structural remodelling in childhood asthma

S. Holgate, D. Davies, S. Wilson, 2005, Thorax.

Bidirectional epithelial–mesenchymal crosstalk provides self-sustaining profibrotic signals in pulmonary fibrosis

Mark G. Jones, P. Skipp, D. Davies, 2021, The Journal of biological chemistry.

Characterization of ciliated bronchial epithelium 1, a ciliated cell-associated gene induced during mucociliary differentiation.

David I. Wilson, S. Holgate, D. Davies, 2004, American journal of respiratory cell and molecular biology.

A novel ACE2 isoform is expressed in human respiratory epithelia and is upregulated in response to interferons and RNA respiratory virus infection

D. Baralle, P. Skipp, R. Djukanović, 2021, Nature Genetics.

A novel ACE2 isoform is expressed in human respiratory epithelia and is upregulated in response to interferons and RNA respiratory virus infection

D. Baralle, P. Skipp, R. Djukanović, 2021, Nature Genetics.

Quantitative Proteomic Analysis in Alveolar Type II Cells Reveals the Different Capacities of RAS and TGF-β to Induce Epithelial–Mesenchymal Transition

Mark G. Jones, P. Skipp, D. Davies, 2021, Frontiers in Molecular Biosciences.

Epithelial function and dysfunction in asthma

D. Davies, M. Loxham, C. Blume, 2014, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

The role of the epithelium in airway remodeling in asthma.

D. Davies, 2009, Proceedings of the American Thoracic Society.

A MicroRNA Network Dysregulated in Asthma Controls IL-6 Production in Bronchial Epithelial Cells

P. Howarth, S. Holgate, D. Davies, 2014, PloS one.

Identification of host miRNAs that may limit human rhinovirus replication.

D. Davies, T. Sanchez-Elsner, N. Bedke, 2014, World journal of biological chemistry.

Targeting the epidermal growth factor receptor for therapy of carcinomas.

D. Davies, S. G. Chamberlin, 1996, Biochemical pharmacology.

Cellular crosstalk between airway epithelial and endothelial cells regulates barrier functions during exposure to double‐stranded RNA

Matthew Loxham, Timothy M. Millar, Marie Held, 2017, Immunity, inflammation and disease.

In vitro and ex vivo models of human asthma.

D. Davies, C. Blume, 2013, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

On-chip epithelial barrier function assays using electrical impedance spectroscopy.

Hywel Morgan, Judith A Holloway, D. Davies, 2010, Lab on a chip.

Phenotypic and genetic aspects of epithelial barrier function in asthmatic patients

D. Davies, M. Loxham, 2017, The Journal of allergy and clinical immunology.

Breakdown in epithelial barrier function in patients with asthma: identification of novel therapeutic approaches.

D. Davies, J. Collins, E. Swindle, 2009, The Journal of allergy and clinical immunology.

The Effects on Bronchial Epithelial Mucociliary Cultures of Coarse, Fine, and Ultrafine Particulate Matter From an Underground Railway Station

Matthew Loxham, Flemming R. Cassee, Martin R. Palmer, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

Physicochemical Characterization of Airborne Particulate Matter at a Mainline Underground Railway Station

Matthew Loxham, Flemming R. Cassee, Martin R. Palmer, 2013, Environmental science & technology.

Asthmatic bronchial epithelium is more susceptible to oxidant-induced apoptosis.

P. Howarth, R. Djukanović, F. Bucchieri, 2001, American journal of respiratory cell and molecular biology.

Rhinovirus 2A is the key protease responsible for instigating the early block to gene expression in infected cells

D. Davies, I. Filippi, C. McCormick, 2019, Journal of Cell Science.

Rhinovirus 2A is the predominant protease responsible for instigating the early block to gene expression encountered in infected cells

D. Davies, I. Filippi, C. McCormick, 2019, bioRxiv.

Involvement of the epidermal growth factor receptor in IL‐13–mediated corticosteroid‐resistant airway inflammation

R. Djukanović, D. Davies, Elizabeth R. Davies, 2020, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Modulation of the receptor binding affinity of amphiregulin by modification of its carboxyl terminal tail.

S. J. Holt, D. Davies, S. G. Chamberlin, 1995, Biochimica et biophysica acta.

ADAM33: a newly identified protease involved in airway remodelling.

S. Holgate, D. Davies, J. Holloway, 2006, Pulmonary pharmacology & therapeutics.

ADAM33: a newly identified gene in the pathogenesis of asthma.

S. Holgate, D. Davies, J. Holloway, 2005, Immunology and allergy clinics of North America.

Identification and possible functions of ADAM33 as an asthma susceptibility gene

S. Holgate, D. Davies, J. Holloway, 2004 .

The discovery and role of ADAM33, a new candidate gene for asthma

S. Holgate, D. Davies, T. Keith, 2004, Expert Reviews in Molecular Medicine.

Adam 33 and its association with airway remodeling and hyperresponsiveness in asthma

S. Holgate, D. Davies, J. Holloway, 2004, Clinical reviews in allergy & immunology.

ADAM33: a novel therapeutic target for asthma

S. Holgate, D. Davies, J. Holloway, 2003, Expert opinion on therapeutic targets.

ADAM 33: just another asthma gene or a breakthrough in understanding the origins of bronchial hyperresponsiveness?

S. Holgate, D. Davies, J. Holloway, 2003, Thorax.

Squamous Metaplasia Is Increased in the Bronchial Epithelium of Smokers with Chronic Obstructive Pulmonary Disease

R. Djukanović, D. Davies, T. Havelock, 2016, PloS one.

The Significance of Valine 33 as a Ligand-specific Epitope of Transforming Growth Factor α*

D. Davies, S. G. Chamberlin, D. Drummond, 1996, The Journal of Biological Chemistry.

Chapter 7 – Airway Remodeling

S. Holgate, D. Davies, R. O'Donnell, 2002 .

A validated hypoxia-inducible factor (HIF) signature across tissue compartments predicts clinical outcome in human lung fibrosis

D. Davies, R. Ewing, M. Jones, 2022, medRxiv.

Multidomain binding of transforming growth factor alpha to the epidermal growth factor receptor.

D. Davies, S. G. Chamberlin, N. Richards, 1992, Biochemistry.

Exogenous IFN-β has antiviral and anti-inflammatory properties in primary bronchial epithelial cells from asthmatic subjects exposed to rhinovirus.

P. Howarth, S. Holgate, D. Davies, 2011, The Journal of allergy and clinical immunology.

Growth inhibitory effects of FK506 and cyclosporin A independent of inhibition of calcineurin.

D. Davies, P. Alexander, A. Richter, 1995, Biochemical pharmacology.

A Disintegrin and Metalloproteinase Domain‐9: A Novel Proteinase Culprit with Multifarious Contributions to Chronic Obstructive Pulmonary Disease

Dave Singh, R. Djukanović, D. Davies, 2018, American journal of respiratory and critical care medicine.

Role of deficient type III interferon-λ production in asthma exacerbations

Stephen T Holgate, Louise Slater, S. Johnston, 2006, Nature Medicine.

Epithelial-mesenchymal transition contributes to pulmonary fibrosis via aberrant epithelial/fibroblastic cross-talk.

Mark G. Jones, D. Davies, Yihua Wang, 2019, Journal of lung health and diseases.

CD40 ligation protects bronchial epithelium against oxidant-induced caspase-independent cell death.

F. Bucchieri, F. Farina, D. Davies, 2006, American journal of respiratory cell and molecular biology.

Kinetic Analysis of the Interleukin-13 Receptor Complex*

Stephen T. Holgate, John W. Holloway, Donna E. Davies, 2002, The Journal of Biological Chemistry.

EGF-Receptor Binding Peptides from Transforming Growth Factor Alpha (TGF Alpha): Evidence for a Multi-Domain Interaction,

D. Davies, M. Ward, C. Higginbotham, 1992 .

Preliminary study of the cellular characteristics of primary bronchial fibroblasts in patients with asthma: expression of alpha-smooth muscle actin, fibronectin containing extra type III domain A, and smoothelin.

P. Howarth, D. Davies, D. Sammut, 2012, Journal of investigational allergology & clinical immunology.

Application of functional genomics to study of inflammatory airways disease

R. Djukanović, S. Holgate, D. Davies, 1999, Thorax.

Rethinking the pathogenesis of asthma.

S. Holgate, D. Davies, 2009, Immunity.

A new look at the pathogenesis of asthma

P. Howarth, G. Roberts, S. Holgate, 2009, Clinical science.

Relationship between peripheral airway dysfunction, airway obstruction, and neutrophilic inflammation in COPD

R. Djukanović, S. Holgate, D. Davies, 2004, Thorax.

Two newly established cell lines derived from the same colonic adenocarcinoma exhibit differences in EGF‐receptor ligand and adhesion molecule expression

D. Davies, I. Campbell, J. Collins, 1995, International journal of cancer.

The association of the cytoplasmic domains of interleukin 4 receptor alpha and interleukin 13 receptor alpha 2 regulates interleukin 4 signaling.

S. Holgate, D. Davies, J. Holloway, 2013, Molecular bioSystems.

Expression of genes involved in oxidative stress responses in airway epithelial cells of smokers with chronic obstructive pulmonary disease.

Stephen T Holgate, Ratko Djukanovic, Per Broberg, 2007, American journal of respiratory and critical care medicine.

Signal transducer and activator of transcription 6 (STAT-6) expression and function in asthmatic bronchial epithelium.

P. Howarth, R. Djukanović, F. Bucchieri, 2001, The Journal of allergy and clinical immunology.

The histone deacetylase inhibitor, romidepsin, as a potential treatment for pulmonary fibrosis

Mark G. Jones, A. Ganesan, P. Skipp, 2017, Oncotarget.

Autocrine ligands of the epithelial growth factor receptor mediate inflammatory responses to diesel exhaust particles

S. Holgate, D. Davies, A. Frew, 2014, Respiratory Research.

Paracrine signalling during ZEB1-mediated epithelial–mesenchymal transition augments local myofibroblast differentiation in lung fibrosis

Mark G. Jones, P. Skipp, D. Davies, 2018, Cell Death & Differentiation.

Rhinovirus-16 Induced Release of IP-10 and IL-8 Is Augmented by Th2 Cytokines in a Pediatric Bronchial Epithelial Cell Model

G. Roberts, S. Holgate, D. Davies, 2014, PloS one.

Inhibition of Pim1 kinase, new therapeutic approach in virus-induced asthma exacerbations

P. Howarth, M. Nawijn, D. Davies, 2016, European Respiratory Journal.

Nanoscale dysregulation of collagen structure-function disrupts mechano-homeostasis and mediates pulmonary fibrosis

Mark G. Jones, D. Davies, P. Thurner, 2018, eLife.

Expression of ErbB receptors and mucins in the airways of long term current smokers

J. Ward, R. Djukanović, S. Holgate, 2004, Thorax.

Nanomechanical assessment of human and murine collagen fibrils via atomic force microscopy cantilever-based nanoindentation.

P. Howarth, D. Davies, P. Thurner, 2014, Journal of the mechanical behavior of biomedical materials.

Shotgun proteomic analysis of human‐induced sputum

B. Nicholas, P. Skipp, R. Djukanović, 2006, Proteomics.

Airway epithelial transcription factor NK2 homeobox 1 inhibits mucous cell metaplasia and Th2 inflammation.

P. Howarth, S. Holgate, D. Davies, 2011, American journal of respiratory and critical care medicine.

Thin film polycrystalline silicon nanowire biosensors.

Kai Sun, Hywel Morgan, Peter Ashburn, 2012, Nano letters.

Epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux

C. Auffray, P. Howarth, Fabio Strazzeri, 2019, European Respiratory Journal.

The Interaction of an Epidermal Growth Factor/Transforming Growth Factor α Tail Chimera with the Human Epidermal Growth Factor Receptor Reveals Unexpected Complexities*

D. Davies, S. G. Chamberlin, S. Puddicombe, 1996, The Journal of Biological Chemistry.

Beta-catenin/T-cell factor-mediated transcription is modulated by cell density in human bronchial epithelial cells.

Stephen T Holgate, John W Holloway, S. Holgate, 2005, The international journal of biochemistry & cell biology.

Constrained peptide analogues of transforming growth factor-alpha residues cysteine 21-32 are mitogenically active. Use of proline mimetics to enhance biological potency.

D. W. Anderson, D. Davies, S. G. Chamberlin, 1995, The Journal of biological chemistry.

Defective Epithelial Barrier Function In Asthma

S. Holgate, D. Davies, J. Haywood, 2011, Asian Test Symposium.

AIRWAY INFLAMMATION AND REMODELLING IN ASTHMA – CAUSE AND EFFECT ?

S. Holgate, D. Davies, 2022 .

Hydration and nanomechanical changes in collagen fibrils bearing advanced glycation end-products.

D. Davies, P. Thurner, K. Elsayad, 2019, Biomedical optics express.

Solution structure of the mEGF/TGFα44−50 chimeric growth factor

Lorraine Brennan, Donna E. Davies, D. Davies, 2001 .

Structure-function studies of ligand-induced epidermal growth factor receptor dimerization.

D. Davies, S. G. Chamberlin, K. Nandagopal, 1998, Biochemistry.

A novel isoform of ACE2 is expressed in human nasal and bronchial respiratory epithelia and is upregulated in response to RNA respiratory virus infection

D. Baralle, P. Skipp, R. Djukanović, 2020, bioRxiv.

Examining lysyl oxidase-like modulation of collagen architecture in 3D spheroid models of idiopathic pulmonary fibrosis via second-harmonic generation microscopy

Paul J. Campagnola, Darian S. James, Christopher J. Brereton, 2021, Journal of biomedical optics.

Vulnerability to acid reflux of the airway epithelium in severe asthma

P. Howarth, J. Ward, R. Djukanović, 2022, European Respiratory Journal.

Barrier responses of human bronchial epithelial cells to grass pollen exposure

Stephen T. Holgate, Claudia Traidl-Hoffmann, Donna E. Davies, 2012, European Respiratory Journal.

Frmd7 expression in developing mouse brain

S. Holgate, D. Davies, H. Haitchi, 2010, Eye.

Tumor necrosis factor alpha (TNF-α) autoregulates its expression and induces adhesion molecule expression in asthma.

J. Ward, S. Holgate, D. Davies, 2011, Clinical immunology.

Structure–mechanics relationships of collagen fibrils in the osteogenesis imperfecta mouse model

S. J. Shefelbine, P. H. Howarth, P. Howarth, 2015, Journal of The Royal Society Interface.

IL-33 Induces an Antiviral Signature in Mast Cells but Enhances Their Permissiveness for Human Rhinovirus Infection

D. Davies, D. Bryant, C. Blume, 2022, Viruses.

Real-time monitoring of epithelial barrier function by impedance spectroscopy in a microfluidic platform.

J. Fernandes, D. Davies, C. Blume, 2022, Lab on a chip.

Relationship between peripheral airway dysfunction, airway obstruction, and neutrophilic inflammation in COPD

R. Djukanović, S. Holgate, D. Davies, 2004, Thorax.

T-helper cell type-2 regulation in allergic disease

M. Gorospe, I. Adcock, D. Davies, 2005, European Respiratory Journal.

Paracrine signalling during ZEB1-mediated epithelial–mesenchymal transition augments local myofibroblast differentiation in lung fibrosis

Mark G. Jones, P. Skipp, D. Davies, 2018, Cell Death & Differentiation.

CHRONIC OBSTRUCTIVE PULMONARY DISEASE Relationship between peripheral airway dysfunction, airway obstruction, and neutrophilic inflammation in COPD

S. Holgate, D. Davies, S. Pierrou, 2004 .

The bronchial epithelium as a key regulator of airway inflammation and remodelling in asthma

S. Holgate, D. Davies, P. Lackie, 1999, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.