P. McCann

发表

Bis(benzyl)polyamine analogs inhibit the growth of chloroquine-resistant human malaria parasites (Plasmodium falciparum) in vitro and in combination with alpha-difluoromethylornithine cure murine malaria.

A. Bitonti, J. Dumont, T. Bush, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Irreversible inhibition of S-adenosylmethionine decarboxylase in Plasmodium falciparum-infected erythrocytes: growth inhibition in vitro.

A. Bitonti, P. McCann, P. Wright, 1991, Biochemical pharmacology.

Experimental Fecal Transmission of Human Cryptosporidia to Pigs, and Attempted Treatment with an Ornithine Decarboxylase Inhibitor

P. McCann, M. Welch, H. Moon, 1982, Veterinary pathology.

Cure of murine Trypanosoma brucei rhodesiense infections with an S-adenosylmethionine decarboxylase inhibitor

A. Bitonti, P. McCann, A. Sjoerdsma, 1992, Antimicrobial Agents and Chemotherapy.

Altered intracellular polyamines in bloodstream form Trypanosoma brucei brucei: transformation to procyclic trypomastigotes.

P. McCann, B. F. Giffin, B. Giffin, 1993, Acta tropica.

Inhibition of polyamine metabolism : biological significance and basis for new therapies

P. McCann, A. Sjoerdsma, A. Pegg, 1987 .

Inhibition of ornithine or arginine decarboxylase as an experimental approach to African or American trypanosomiasis.

A. Bitonti, P. McCann, A. Sjoerdsma, 1988, Advances in experimental medicine and biology.

Arginine decarboxylase inhibitors reduce the capacity of Trypanosoma cruzi to infect and multiply in mammalian host cells.

P. McCann, A. Sjoerdsma, F. Kierszenbaum, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Uptake of α-difluoromethylornithine by Trypanosoma brucei brucei

A. Bitonti, P. McCann, A. Sjoerdsma, 1986 .

Necessity of antibody response in the treatment of African trypanosomiasis with alpha-difluoromethylornithine.

A. Bitonti, P. McCann, A. Sjoerdsma, 1986, Biochemical pharmacology.

Systemic absorption of insulin and glucagon applied topically to the eyes of rats and a diabetic dog.

P. McCann, E. Meezan, D. Pillion, 1995, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.

Antitrypanosomal effects of polyamine biosynthesis inhibitors correlate with increases in Trypanosoma brucei brucei S-adenosyl-L-methionine.

A. Bitonti, T. Bush, P. McCann, 1991, The Biochemical journal.

Two distinct mechanisms for ornithine decarboxylase regulation by polyamines in rat hepatoma cells

P. McCann, C. Tardif, P. Böhlen, 1979, Journal of cellular physiology.

Alpha-methyl ornithine, a potent competitive inhibitor of ornithine decarboxylase, blocks proliferation of rat hepatoma cells in culture.

P. McCann, C. Tardif, F. Schuber, 1976, Proceedings of the National Academy of Sciences of the United States of America.

Antihuman Immunodeficiency Virus (HIV-1) Activities of Inhibitors of Polyamine Pathways.

D. Burke, P. McCann, P. Chiang, 1996, Journal of biomedical science.

Polyamine depletion following exposure to DL-alpha-difluoromethylornithine both in vivo and in vitro initiates morphological alterations and mitochondrial activation in a monomorphic strain of Trypanosoma brucei brucei.

A. Bitonti, P. McCann, C. Bacchi, 1986, The Journal of protozoology.

DL-alpha-(Difluoromethyl)arginine: a potent enzyme-activated irreversible inhibitor of bacterial decarboxylases.

P. McCann, P. Bey, A. Kallio, 1981, Biochemistry.

In vivo effects of α-dl-Difluoromethylornithine on the metabolism and morphology of Trypanosoma brucei brucei

P. McCann, A. Sjoerdsma, A. Pegg, 1983 .

Difluoromethylornithine irreversibly inactivates ornithine decarboxylase of Pseudomonas aeruginosa, but does not inhibit the enzymes of Escherichia coli.

P. McCann, A. Kallio, 1981, Biochemical Journal.

Assaying ornithine and arginine decarboxylases in some plant species.

A. Bitonti, P. McCann, H. Birecka, 1985, Plant physiology.

Catalytic irreversible inhibition of bacterial and plant arginine decarboxylase activities by novel substrate and product analogues.

A. Bitonti, P. McCann, P. Casara, 1987, The Biochemical journal.

Polyamine metabolism and function.

P. McCann, A E Pegg, P P McCann, 1982, The American journal of physiology.

Long-Term Maintenance Therapy of Established Human Small Cell Variant Lung Carcinoma Implants in Athymic Mice with a Cyclic Regimen of Difluoromethylornithine1

Stephen, P. McCann, A. Sjoerdsma, 2006 .

Long-Term Maintenance Therapy of Established Human Small Cell Variant Lung Carcinoma Implants in Athymic Mice with a Cyclic Regimen of Difluoromethylornithine 1

P. McCann, A. Sjoerdsma, M. Abeloff, 2006 .

Alpha-difluoromethylornithine resistance in Leishmania donovani is associated with increased ornithine decarboxylase activity.

A. Bitonti, P. McCann, B. Ullman, 1990, Molecular and biochemical parasitology.

Trypanosoma brucei brucei: regulation of ornithine decarboxylase in procyclic forms and trypomastigotes.

A. Bitonti, P. McCann, C. Bacchi, 1989, Experimental parasitology.

Impairment of macrophage function by inhibitors of ornithine decarboxylase activity

P. McCann, A. Sjoerdsma, F. Kierszenbaum, 1987, Infection and immunity.

Enzyme-Activated Irreversible Inhibition of Bacterial and Plant Arginine Decarboxylase, by Either Substrate or Product Analogues

P. McCann, P. Casara, P. Bey, 1987 .

Effects of DL-alpha-difluoromethylornithine on Leishmania donovani promastigotes.

P. McCann, A. Sjoerdsma, B. Ullman, 1986, The Journal of protozoology.

Inhibition of Ornithine Decarboxylase and Growth of the Fungus Helminthosporium maydis.

P. McCann, M. Garraway, H. Birecka, 1986, Plant physiology.

Identification of polyamines in the cochlea of the rat and their potential role in hearing

J. H. Casseday, P. McCann, A. Sjoerdsma, 1986, Brain Research Bulletin.

Alterations in polyamine metabolism during embryonal carcinoma cell differentiation in vitro.

P. McCann, M. Kelly, J. Schindler, 1985, Developmental biology.

Activities of arginine and ornithine decarboxylases in various plant species.

A. Bitonti, P. McCann, H. Birecka, 1985, Plant physiology.

The response of several murine embryonal carcinoma cell lines to stimulation of differentiation by α‐difluoromethylornithine

P. McCann, M. Kelly, J. Schindler, 1985, Journal of cellular physiology.

Induction of ornithine decarboxylase in Leptomonas seymouri.

P. McCann, C. Bacchi, J. C. Hannan, 1984, Molecular and biochemical parasitology.

Inhibition of growth of Giardia lamblia by difluoromethylornithine, a specific inhibitor of polyamine biosynthesis.

D. S. Reiner, P. McCann, F. Gillin, 1984, The Journal of protozoology.

Intestinal changes caused by DL-alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase.

P. McCann, D. E. Loudy, J. Yarrington, 1983, Experimental and molecular pathology.

Divergent effects of ornithine decarboxylase inhibition on murine erythropoietic precursor cell proliferation and differentiation.

P. McCann, E. Niskanen, A. Thornhill, 1983, Cancer research.

Potentiation of the antitumor therapeutic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea by alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor.

P. McCann, A. Sjoerdsma, L. Marton, 1981, Cancer research.

Biphasic induction of ornithine decarboxylase and putrescine levels in growing HTC cells.

P. McCann, F. Schuber, P. Mamont, 1975, Biochemical and biophysical research communications.

Characterization of spermidine synthase from Trypanosoma brucei brucei.

A. Bitonti, P. McCann, S. Kelly, 1984, Molecular and biochemical parasitology.

Regulation of growth and macromolecular synthesis by putrescine and spermidine in Pseudomonas aeruginosa.

A. Bitonti, P. McCann, S. Kelly, 1984, Life sciences.

Resistance to DL-alpha-difluoromethylornithine by clinical isolates of Trypanosoma brucei rhodesiense. Role of S-adenosylmethionine.

P. McCann, N. Yarlett, D. Rattendi, 1993, Biochemical pharmacology.

Nuclease digestion of the DNA-protein complex from simian virus 40 virions.

P. McCann, R. Martin, 1975, Biochimica et biophysica acta.

Enzymes as Targets for Drug Design

P. McCann, M. Palfreyman, W. Lovenberg, 1990 .

dl-α-difluoromethyl[3,4-3H]arginine metabolism in tobacco and mammalian cells. Inhibition of ornithine decarboxylase activity after arginase-mediated hydrolysis of dl-α-difluoromethylarginine to dl-α-difluoromethylornithine

A. Bitonti, P. McCann, R. P. Feirer, 1988 .

Regulation of ornithine decarboxylase by ODC-antizyme in HTC cells.

P. McCann, C. Tardif, P. Mamont, 1977, Biochemical and biophysical research communications.

Inhibition of polyamine metabolism

P. McCann, A. Sjoerdsma, A. Pegg, 1988, Plant Growth Regulation.

Ornithine decarboxylase, polyamines, and pyrrolizidine alkaloids in senecio and crotalaria.

A. Bitonti, P. McCann, E. Cohen, 1988, Plant physiology.

Synergism between 9-deazainosine and DL-alpha-difluoromethylornithine in treatment of experimental African trypanosomiasis

P. McCann, R. Klein, C. Bacchi, 1987, Antimicrobial Agents and Chemotherapy.

Inhibition of Trypanosoma brucei brucei peptidyl transferase activity by sparsomycin analogs and effects on trypanosome protein synthesis and proliferation.

A. Bitonti, P. McCann, G. Flynn, 1985, Biochemical pharmacology.

Inhibition of ornithine decarboxylase with 2-difluoromethylornithine: reduced incidence of dimethylhydrazine-induced colon tumors in mice.

P. McCann, R. Malt, A. Kingsnorth, 1983, Cancer research.

S‐Adenosylmetliionine and methylation

R K Gordon, P K Chiang, P. McCann, 1996, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Antimalarial polyamine analogues.

A. Bitonti, J. Dumont, M. L. Edwards, 1991, Journal of medicinal chemistry.

Efficacy of combinations of difluoromethylornithine and bleomycin in a mouse model of central nervous system African trypanosomiasis.

P. McCann, A. Sjoerdsma, C. Bacchi, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Plasmodium falciparum and Plasmodium berghei: effects of ornithine decarboxylase inhibitors on erythrocytic schizogony.

A. Bitonti, P. McCann, A. Sjoerdsma, 1987, Experimental parasitology.

Suppression of Leishmania donovani by oral administration of a bis(benzyl)polyamine analog

A. Bitonti, P. McCann, R. J. Baumann, 1991, Antimicrobial Agents and Chemotherapy.

15 – Parasitic Protozoa and Polyamines

P. McCann, C. Bacchi, 1987 .

Polyamine metabolism: a potential therapeutic target in trypanosomes.

P. McCann, A. Sjoerdsma, S. Hutner, 1980, Science.

Novel combination chemotherapy of experimental trypanosomiasis by using bleomycin and DL-alpha-difluoromethylornithine; reversal by polyamines.

P. McCann, A. Sjoerdsma, S. Hutner, 1982, Biochemical pharmacology.

Inhibition of multiplication in Acanthamoeba castellanii by specific inhibitors of ornithine decarboxylase.

P. McCann, T. J. Byers, B. -. Kim, 1987, The Journal of protozoology.

Physiological activation of the mitochondrion and the transformation capacity of DFMO induced intermediate and short stumpy bloodstream form trypanosomes.

P. McCann, B. Giffin, 1989, The American journal of tropical medicine and hygiene.

12 – Inhibition of Polyamine Biosynthesis in Microorganisms

A. Bitonti, P. McCann, 1987 .

Inhibition of growth of Mycoplasma dispar by DL-alpha-difluoromethyllsine, a selective irreversible inhibitor of lysine decarboxylase, and reversal by cadaverine (1,5-diaminopentane).

P. McCann, A. Sjoerdsma, H. Pösö, 1984, Biochemical and biophysical research communications.

Antimalarial activity of a 4',5'-unsaturated 5'-fluoroadenosine mechanism-based inhibitor of S-adenosyl-L-homocysteine hydrolase.

A. Bitonti, P. McCann, J. Mccarthy, 1990, Biochemical pharmacology.

Trophic Responses of the Pancreas Differ in Aging Rats

P. McCann, P. Holt, Ronald E. Greenberg, 1988, Pancreas.

Ehndogenous polyamine levels and dark-induced leaf senescence

A. Bitonti, P. McCann, K. Ireton, 1991 .

Catalytic irreversible inhibition of Trypanosoma brucei brucei ornithine decarboxylase by substrate and product analogs and their effects on murine trypanosomiasis.

A. Bitonti, P. McCann, A. Sjoerdsma, 1985, Biochemical pharmacology.

Regulation of hematopoiesis II: the role of polyamine inhibition on helper or suppressor influences of the thymus.

P. McCann, M. Collector, S. Sharkis, 1983, Blood.

DL-a-Monofluoromethylputrescine is a potent irreversible inhibitor of Escherichia coli ornithine decarboxylase.

P. McCann, P. Bey, A. Kallio, 1982, The Biochemical journal.

The effects of polyamine analogues on malaria parasites in vitro and in vivo.

A. Bitonti, P. McCann, A. Sjoerdsma, 1988, Advances in experimental medicine and biology.

Apparent ornithine decarboxylase activity, measured by 14CO2 trapping, after frozen storage of rat tissue and rat tissue supernatants.

P. McCann, D. Gaines, L. Friedman, 1988, Analytical biochemistry.

Effects of α-Difluoromethylornithine and 5-Fluorouracil on the Proliferation of a Human Colon Adenocarcinoma Cell Line

P. McCann, W. Russell, R. Malt, 1983 .

S-adenosylmethionine decarboxylase as an enzyme target for therapy.

P. McCann, A. Pegg, 1992, Pharmacology & therapeutics.

Cure of Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense infections in mice with an irreversible inhibitor of S-adenosylmethionine decarboxylase

A. Bitonti, T. Bush, P. McCann, 1990, Antimicrobial Agents and Chemotherapy.

Dicyclohexylamine effects on HTC cell polyamine content and ornithine decarboxylase activity.

P. McCann, P. Qasba, J. L. Mitchell, 1985, Biochimica et biophysica acta.

Regulatory interrelations between GABA and polyamines. II. Effect of GABA on ornithine decarboxylase and putrescine levels in cell culture

P. McCann, N. Seiler, J. Hornsperger, 1979, Neurochemical Research.

Effect of alpha-methyl ornithine on ornithine decarboxylase activity of rat hepatoma cells in culture.

P. McCann, C. Tardif, P. Mamont, 1977, Biochemical and biophysical research communications.

Ornithine decarboxylase as an enzyme target for therapy.

P. McCann, A. Pegg, P P McCann, 1992, Pharmacology & therapeutics.

bis(benzyl)polyamine analogues are substrates for a mammalian cell-transport system which is distinct from the polyamine-transport system.

A. Bitonti, P. McCann, T. Byers, 1990, The Biochemical journal.

Characterization of Trypanosoma brucei brucei S-adenosyl-L-methionine decarboxylase and its inhibition by Berenil, pentamidine and methylglyoxal bis(guanylhydrazone).

A. Bitonti, J. Dumont, P. McCann, 1986, The Biochemical journal.

Uptake of antimalarial bis(benzyl)polyamine analogs by human erythrocytes.

A. Bitonti, J. Dumont, P. McCann, 1989, Biochemical pharmacology.

DESIPRAMINE AND CYPROHEPTADINE FOR REVERSAL OF CHLOROQUINE RESISTANCE IN PLASMODIUM FALCIPARUM

A. Bitonti, P. McCann, 1989, The Lancet.

Reversal of chloroquine resistance in malaria parasite Plasmodium falciparum by desipramine.

A. Bitonti, P. McCann, A. Sjoerdsma, 1988, Science.

Matrix metalloproteinase inhibition as a novel anticancer strategy: a review with special focus on batimastat and marimastat.

P. McCann, H. Rasmussen, 1997, Pharmacology & therapeutics.

Role of antibody in the elimination of trypanosomes after DL-alpha-difluoromethylornithine chemotherapy.

P. McCann, A. L. D. de Gee, J. M. Mansfield, 1983, The Journal of parasitology.

Combination chemotherapy of drug-resistant Trypanosoma brucei rhodesiense infections in mice using DL-alpha-difluoromethylornithine and standard trypanocides

P. McCann, A. Sjoerdsma, N. Yarlett, 1994, Antimicrobial Agents and Chemotherapy.

Polyamine metabolism in Acanthamoeba: polyamine content and synthesis of ornithine, putrescine, and diaminopropane.

A. Bitonti, P. McCann, A. Sobota, 1987, The Journal of protozoology.

Effect of bis(benzyl)polyamine derivatives on polyamine transport and survival ofBrugia pahangi

S. Müller, P. McCann, R. D. Walter, 2004, Parasitology Research.

Morphological changes in Trypanosoma brucei rhodesiense following inhibition of polyamine biosynthesis in vivo.

P. McCann, A. L. D. de Gee, J. M. Mansfield, 1984, Tissue & cell.

Effect of putrescine on the respiration of Trypanosoma brucei brucei.

P. McCann, C. Bacchi, B. Giffin, 1986, Molecular and biochemical parasitology.

Regulation of polyamine biosynthesis in rat hepatoma (HTC) cells by a bisbenzyl polyamine analogue.

A. Bitonti, T. Bush, P. McCann, 1989, The Biochemical journal.

Inhibition of ileal and colonic ornithine decarboxylase activity by alpha-difluoromethylornithine in rats: transient atrophic changes and loss of postresectional adaptive growth.

P. McCann, G. LaMuraglia, R. Malt, 1986, Surgery.

Bis(benzyl)polyamine analogs as novel substrates for polyamine oxidase.

A. Bitonti, J. Dumont, T. Bush, 1990, The Journal of biological chemistry.

Haematological Cell Proliferation and Differentiation Responses to Perturbations of Polyamine Biosynthesis

P. McCann, E. Niskanen, G. O'Conor, 1986, Cell and tissue kinetics.

Inhibition of arginine, ornithine and lysine decarboxylases in pea seedlings

A. Bitonti, P. McCann, H. Birecka, 1991 .

Inhibition of ornithine decarboxylase induces embryonal carcinoma cell differentiation.

P. McCann, M. Kelly, J. Schindler, 1983, Biochemical and biophysical research communications.

Regulatory mutants of the tryptophan operon of Salmonella typhimurium.

P. McCann, A. Smith, R. Callahan, 1970, Genetics.

New drug combination for experimental late-stage African trypanosomiasis: DL-alpha-difluoromethylornithine (DFMO) with suramin.

P. McCann, A. Sjoerdsma, S. Hutner, 1984, The American journal of tropical medicine and hygiene.

Effects of the ornithine decarboxylase inhibitors DL-alpha-difluoromethylornithine and alpha-monofluoromethyldehydroornithine methyl ester alone and in combination with suramin against Trypanosoma brucei brucei central nervous system models.

A. Bitonti, P. McCann, A. Sjoerdsma, 1987, The American journal of tropical medicine and hygiene.

Suppression of both antimony-susceptible and antimony-resistant Leishmania donovani by a bis(benzyl)polyamine analog

A. Bitonti, P. McCann, A. Sjoerdsma, 1990, Antimicrobial Agents and Chemotherapy.

Methods for the study of the treatment of protozoan diseases by inhibitors of ornithine decarboxylase.

P. McCann, A. Sjoerdsma, S. Hutner, 1983, Methods in enzymology.

Further studies on difluoromethylornithine in African trypanosomes.

P. McCann, A. Sjoerdsma, J. Seed, 1981, Medical biology.

Inhibition of bacterial aminopropyltransferases by S‐adenosyl‐1,8‐diamino‐3‐thiooctane and by dicyclohexylamine

A. Bitonti, P. McCann, A. Pegg, 1983, FEBS letters.

alpha-Difluoromethylornithine: a promising lead for preventive chemotherapy for coccidiosis.

P. McCann, A. Sjoerdsma, M. M. Bradford, 1982, American journal of veterinary research.

Disruption of Plasmodium falciparum-infected erythrocyte cytoadherence to human melanoma cells with inhibitors of glycoprotein processing.

A. Bitonti, P. McCann, P. Wright, 1991, Biochemical pharmacology.

Plasmodium falciparum: a rapid assay for cytoadherence of [3H]hypoxanthine-labeled infected erythrocytes to human melanoma cells.

A. Bitonti, P. McCann, P. Wright, 1990, Experimental parasitology.

Restriction of bacterial growth by inhibition of polyamine biosynthesis by using monofluoromethylornithine, difluoromethylarginine and dicyclohexylammonium sulphate.

A. Bitonti, P. McCann, A. Sjoerdsma, 1982, The Biochemical journal.

Effects of alpha-difluoromethylornithine on the growth of experimental Wilms' tumor and renal adenocarcinoma.

P. McCann, R. Malt, A. Kingsnorth, 1983, Cancer research.

Effects of a-Difluoromethylornithine on the Growth of Experimental Wilms' Tumor and Renal Adenocarcinoma1

P. McCann, R. Malt, A. Kingsnorth, 2006 .

Curative effect of alpha-difluoromethylornithine on fatal Trypanosoma congolense infection in mice.

P. McCann, A. Sjoerdsma, E. Karbe, 1982, Tropenmedizin und Parasitologie.

Effects of α-difluoromethylornithine on protein synthesis and synthesis of the variant-specific glycoprotein (VSG) in Trypanosoma brucei brucei

A. Bitonti, P. McCann, D. Cross-Doersen, 1988 .

Plasmodium berghei: inhibitors of ornithine decarboxylase block exoerythrocytic schizogony.

P. McCann, A. Sjoerdsma, M. Hollingdale, 1985, Experimental parasitology.

Inhibition of polyamine biosynthesis by alpha-difluoromethylornithine in African trypanosomes and Pneumocystis carinii as a basis of chemotherapy: biochemical and clinical aspects.

P. McCann, A. Sjoerdsma, P. Walzer, 1986, The American journal of tropical medicine and hygiene.

The role of polyamine biosynthesis in hematopoietic precursor cell proliferation in mice.

P. McCann, D. Baker, E. Niskanen, 1983, Blood.

Long-term maintenance therapy of established human small cell variant lung carcinoma implants in athymic mice with a cyclic regimen of difluoromethylornithine.

P. McCann, A. Sjoerdsma, M. Abeloff, 1986, Cancer research.

Effect of GABA and isogabaculine on ornithine decarboxylase and putrescine metabolism.

P. McCann, B. Lippert, K. Diekema, 1982, The American journal of physiology.