S. Kappe

发表

Malaria parasite pre-erythrocytic stage infection: gliding and hiding.

A. Vaughan, A. Aly, S. Kappe, 2008, Cell host & microbe.

A combined transcriptome and proteome survey of malaria parasite liver stages

Xinxia Peng, S. Kappe, A. Tarun, 2008, Proceedings of the National Academy of Sciences.

Protection against malaria at 1 year and immune correlates following PfSPZ vaccination

Mario Roederer, Sumana Chakravarty, Martha C Nason, 2016, Nature Medicine.

A public antibody lineage that potently inhibits malaria infection by dual binding to the circumsporozoite protein

S. Hoffman, I. Wilson, S. Kappe, 2018, Nature Medicine.

Humoral protection against mosquito bite-transmitted Plasmodium falciparum infection in humanized mice

Erika L. Flannery, S. Hoffman, A. Vaughan, 2017, npj Vaccines.

Malaria: progress, perils, and prospects for eradication.

S. Kappe, D. Kyle, D. Fidock, 2008, The Journal of clinical investigation.

Bulk Segregant Approaches to Nutritional Genomics in Plasmodium falciparum

A. Vaughan, S. Kappe, Nelly Camargo, 2020 .

Genetic mapping of fitness determinants across the malaria parasite Plasmodium falciparum life cycle

A. Vaughan, S. Kappe, F. Nosten, 2019, bioRxiv.

Towards functional antibody-based vaccines to prevent pre-erythrocytic malaria infection

S. Kappe, D. Sather, B. Sack, 2017, Expert review of vaccines.

CD40 Is Required for Protective Immunity against Liver Stage Plasmodium Infection

A. Vaughan, S. Kappe, I. N. Crispe, 2015, The Journal of Immunology.

Th1-like Plasmodium-Specific Memory CD4+ T Cells Support Humoral Immunity.

A. Vaughan, S. Kappe, R. Vijay, 2017, Cell reports.

Alterations in Phosphorylation of Hepatocyte Ribosomal Protein S6 Control Plasmodium Liver Stage Infection.

John D Aitchison, Elizabeth K. K. Glennon, S. Kappe, 2019, Cell reports.

Quantitative Bioluminescent Imaging of Pre-Erythrocytic Malaria Parasite Infection Using Luciferase-Expressing Plasmodium yoelii

A. Vaughan, S. Kappe, B. Sack, 2013, PloS one.

Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection

G. Superti-Furga, S. Kappe, M. Mota, 2013, Nature Medicine.

Host ER stress during malaria parasite infection

S. Kappe, A. Kaushansky, 2015, EMBO reports.

Malaria parasites target the hepatocyte receptor EphA2 for successful host infection

S. Kappe, D. Sather, V. Vigdorovich, 2015, Science.

Host-based Prophylaxis Successfully Targets Liver Stage Malaria Parasites.

S. Kappe, A. Kaushansky, S. Mikolajczak, 2015, Molecular therapy : the journal of the American Society of Gene Therapy.

Editorial introductions vii Editorial introductions. Tropical and travel-associated diseases 449 Etiology of travel-related fever.

Mary E. Wilson, A. Aly, S. Kappe, 2007 .

A replication-competent late liver stage-attenuated human malaria parasite.

A. Vaughan, S. Kappe, Nelly Camargo, 2020, JCI insight.

Extrahepatic Exoerythrocytic Forms of Rodent Malaria Parasites at the Site of Inoculation: Clearance after Immunization, Susceptibility to Primaquine, and Contribution to Blood-Stage Infection

S. Kappe, P. Sinnis, Jessica L Miller, 2012, Infection and Immunity.

Safety, pharmacokinetics and causal prophylactic efficacy of KAF156 in a Plasmodium falciparum human infection study.

J. Kublin, A. Vaughan, S. Kappe, 2020, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Assessing drug efficacy against Plasmodium falciparum liver stages in vivo.

Erika L. Flannery, S. Kappe, Nelly Camargo, 2018, JCI insight.

A human monoclonal antibody prevents malaria infection and defines a new site of vulnerability on Plasmodium falciparum circumsporozoite protein

Alex B. Miller, S. Hoffman, H. Liao, 2018, Nature Medicine.

AMINOACYLATION PATHWAY THE FIRST ENZYME IN AN INDIRECT Apicoplast: Plasmodium Synthetase in the A Nondiscriminating Glutamyl-tRNA Enzymology:

M. Gardner, S. Kappe, M. Peterson, 2014 .

Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes.

Steven M. Johnson, Dustin J Maly, C. Verlinde, 2014, European journal of medicinal chemistry.

Preerythrocytic, live-attenuatedPlasmodium falciparumvaccine candidates by design

A. Aly, S. Kappe, A. Cowman, 2009 .

A Malaria Parasite Cross Reveals Genetic Determinants of Plasmodium falciparum Growth in Different Culture Media

A. Vaughan, S. Kappe, Nelly Camargo, 2022, Frontiers in Cellular and Infection Microbiology.

An expanding toolkit for preclinical pre-erythrocytic malaria vaccine development: bridging traditional mouse malaria models and human trials.

S. Kappe, B. Sack, R. Steel, 2016, Future microbiology.

A rapid and scalable density gradient purification method for Plasmodium sporozoites

A. Vaughan, S. Kappe, J. Sattabongkot, 2012, Malaria Journal.

Extensive Transcriptional and Translational Regulation Occur During the Maturation of Malaria Parasite Sporozoites

Kristian E. Swearingen, R. Moritz, S. Kappe, 2019 .

The Plasmodium liver-specific protein 2 (LISP2) is an early marker of liver stage development

Erika L. Flannery, A. Vaughan, S. Kappe, 2019, eLife.

Plasmodium GPI-Anchored Micronemal Antigen is essential for parasite transmission through the mosquito host

Kristian E. Swearingen, R. Moritz, A. Vaughan, 2022, bioRxiv.

Coimmunization with Preerythrocytic Antigens alongside Circumsporozoite Protein Can Enhance Sterile Protection against Plasmodium Sporozoite Infection

S. Kappe, P. Edlefsen, D. Sather, 2022, bioRxiv.

SSP3 Is a Novel Plasmodium yoelii Sporozoite Surface Protein with a Role in Gliding Motility

S. Kappe, K. Hybiske, D. Sather, 2014, Infection and Immunity.

Innate immunity limits protective adaptive immune responses against pre-erythrocytic malaria parasites

A. Vaughan, S. Kappe, N. Minkah, 2019, Nature Communications.

Plasmodium falciparum Liver Stage Infection and Transition to Stable Blood Stage Infection in Liver-Humanized and Blood-Humanized FRGN KO Mice Enables Testing of Blood Stage Inhibitory Antibodies (Reticulocyte-Binding Protein Homolog 5) In Vivo

Erika L. Flannery, S. Kappe, Nelly Camargo, 2018, Front. Immunol..

Development of humanized mouse models to study human malaria parasite infection.

A. Vaughan, S. Kappe, A. Ploss, 2012, Future microbiology.

A specific inhibitor of PfCDPK4 blocks malaria transmission: chemical-genetic validation.

Dustin J Maly, X. Su, K. Comess, 2014, The Journal of infectious diseases.

Speci fi c Inhibitor of Pf CDPK 4 Blocks Malaria Transmission : Chemical-genetic Validation

X. Su, K. Comess, W. V. Voorhis, 2013 .

Natural variation within the principal adhesion domain of the Plasmodium vivax duffy binding protein

J. Adams, M. Alpers, S. Kappe, 1994, Infection and immunity.

This information is current as Infection Plasmodium against Liver Stage CD 40 Is Required for Protective Immunity

A. Vaughan, S. Kappe, Jessica L Miller, 2015 .

Transcriptome and histone epigenome of Plasmodium vivax

Erika L. Flannery, R. Moritz, S. Kappe, 2018 .

Conserved Protective Mechanisms in Radiation and Genetically Attenuated uis3(-) and uis4(-) Plasmodium Sporozoites

S. Kappe, V. Nussenzweig, A. Tarun, 2009, PloS one.

Correction: Corrigendum: Protection against malaria at 1 year and immune correlates following PfSPZ vaccination

Andrea A. Berry, S. Hoffman, S. Kappe, 2016, Nature Medicine.

Immunization of Mice with Live-Attenuated Late Liver Stage-Arresting Plasmodium yoelii Parasites Generates Protective Antibody Responses to Preerythrocytic Stages of Malaria

M. Vignali, A. Vaughan, S. Kappe, 2014, Infection and Immunity.

Genetically Attenuated Parasite Vaccines Induce Contact-Dependent CD8+ T Cell Killing of Plasmodium yoelii Liver Stage-Infected Hepatocytes1

S. Kappe, T. Richie, Ruobing Wang, 2009, The Journal of Immunology.

Stage-Infected Hepatocytes Liver Plasmodium yoelii Killing of T Cell + Induce Contact-Dependent CD 8 Genetically Attenuated Parasite Vaccines

S. Kappe, T. Richie, Ruobing Wang, 2009 .

A genetically engineered Plasmodium falciparum parasite vaccine provides protection from controlled human malaria infection

J. Kublin, A. Vaughan, S. Kappe, 2022, Science Translational Medicine.

Chemoprophylaxis vaccination: Phase 1 study to explore stage-specific immunity to Plasmodium falciparum in U.S. adults.

J. Kublin, K. Stuart, S. Kappe, 2019, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Beyond Blood Smears: Qualification of Plasmodium 18S rRNA as a Biomarker for Controlled Human Malaria Infections

S. Hoffman, J. Kublin, A. Vaughan, 2019, The American journal of tropical medicine and hygiene.

Designer Parasites: Genetically Engineered Plasmodium as Vaccines To Prevent Malaria Infection

S. Kappe, N. Minkah, Debashree Goswami, 2019, The Journal of Immunology.

Immunization of Malaria-Preexposed Volunteers With PfSPZ Vaccine Elicits Long-Lived IgM Invasion-Inhibitory and Complement-Fixing Antibodies

Erika L. Flannery, S. Hoffman, S. Kappe, 2018, The Journal of infectious diseases.

Genetically attenuated malaria parasites as vaccines

A. Vaughan, S. Kappe, 2017, Expert review of vaccines.

Colocalization of a CD1d-Binding Glycolipid with a Radiation-Attenuated Sporozoite Vaccine in Lymph Node–Resident Dendritic Cells for a Robust Adjuvant Effect

Min Zhang, D. Ho, Chi‐Huey Wong, 2015, The Journal of Immunology.

Measurement of Antibody-Mediated Reduction of Plasmodium yoelii Liver Burden by Bioluminescent Imaging.

A. Vaughan, S. Kappe, B. Sack, 2015, Methods in molecular biology.

Flow Cytometry-Based Assessment of Antibody Function Against Malaria Pre-erythrocytic Infection.

S. Kappe, A. Kaushansky, A. Douglass, 2015, Methods in molecular biology.

Author Correction: A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite

Alex B. Miller, S. Hoffman, H. Liao, 2018, Nature Medicine.

Partial protection against P. vivax infection diminishes hypnozoite burden and blood-stage relapses.

Erika L. Flannery, S. Kappe, D. Sather, 2021, Cell host & microbe.

A Humanized Mouse Model for Plasmodium vivax to Test Interventions that Block Liver Stage to Blood Stage Transition and Blood Stage Infection

Erika L. Flannery, S. Kappe, D. Sather, 2020, iScience.

A Plasmodium Parasite with Complete Late Liver Stage Arrest Protects against Preerythrocytic and Erythrocytic Stage Infection in Mice

A. Vaughan, S. Kappe, B. Sack, 2018, Infection and Immunity.

Surprising variation in the outcome of two malaria genetic crosses using humanized mice: implications for genetic mapping and malaria biology

A. Vaughan, S. Kappe, F. Nosten, 2019, bioRxiv.

Mass Spectrometry Identification of Biomarkers in Extracellular Vesicles From Plasmodium vivax Liver Hypnozoite Infections

Erika L. Flannery, S. Kappe, H. D. del Portillo, 2022, Molecular & cellular proteomics : MCP.

Short-Lived Effector CD8 T Cells Induced by Genetically Attenuated Malaria Parasite Vaccination Express CD11c

M. Gardner, S. Kappe, J. Aitchison, 2013, Infection and Immunity.

Genetically attenuated Plasmodium berghei liver stages induce sterile protracted protection that is mediated by major histocompatibility complex Class I-dependent interferon-gamma-producing CD8+ T cells.

S. Kappe, Hilda Silva-Rivera, K. Matuschewski, 2007, The Journal of infectious diseases.

The amino acid transporter pfaat1 modulates chloroquine resistance and fitness in malaria parasites

D. Kwiatkowski, D. Conway, R. Pearson, 2022, bioRxiv.

PfARID Regulates P. falciparum Malaria Parasite Male Gametogenesis and Female Fertility and Is Critical for Parasite Transmission to the Mosquito Vector

A. Vaughan, S. Kappe, V. Baranwal, 2022, mBio.

A scalable assessment of Plasmodium falciparum transmission in the standard membrane-feeding assay, using transgenic parasites expressing green fluorescent protein-luciferase.

A. Vaughan, S. Kappe, T. Bousema, 2014, The Journal of infectious diseases.

A Plasmodium falciparum ATP-binding cassette transporter is essential for liver stage entry into schizogony

A. Vaughan, S. Kappe, Debashree Goswami, 2022, iScience.

Plasmodium 18S rRNA of intravenously administered sporozoites does not persist in peripheral blood

S. Hoffman, S. Kappe, R. Seder, 2018, Malaria Journal.

Malaria vaccine development: persistent challenges.

A. Vaughan, S. Kappe, 2012, Current opinion in immunology.

Malaria parasites utilize two essential plasma membrane fusogens for gamete fertilization

A. Vaughan, S. Kappe, B. Podbilewicz, 2022, Cellular and Molecular Life Sciences.

Malaria parasite development in the mosquito and infection of the mammalian host.

A. Vaughan, A. Aly, S. Kappe, 2009, Annual review of microbiology.

Subcutaneous Immunization with Unaltered Axenic Malaria Parasite Liver Stages Induces Sterile Protection against Infectious Sporozoite Challenge

A. Aly, S. Kappe, M. Kamil, 2022, Vaccines.

The Micronemal Plasmodium Proteins P36 and P52 Act in Concert to Establish the Replication-Permissive Compartment Within Infected Hepatocytes

Kristian E. Swearingen, R. Moritz, A. Vaughan, 2018, Front. Cell. Infect. Microbiol..

Vaccination using radiation- or genetically attenuated live sporozoites.

A. Vaughan, S. Kappe, 2013, Methods in molecular biology.

An efficient strategy for gene targeting and phenotypic assessment in the Plasmodium yoelii rodent malaria model.

A. Vaughan, A. Aly, S. Kappe, 2008, Molecular and biochemical parasitology.

Sequence analysis of the apical membrane antigen-1 genes (ama-1) of Plasmodium yoelii yoelii and Plasmodium berghei.

J. Adams, S. Kappe, 1996, Molecular and biochemical parasitology.

A conserved Plasmodium protein that localizes to liver stage nuclei is critical for late liver stage development

A. Vaughan, S. Kappe, Silvia A. Arredondo, 2022, bioRxiv.

Malaria parasites harness Rho GTPase signaling and host cell membrane ruffling for productive invasion of hepatocytes.

S. Kappe, Sudhir Kumar, Antonino Schepis, 2022, Cell reports.

Malaria parasite liver stages render host hepatocytes susceptible to mitochondria-initiated apoptosis

S. Kappe, A. Kaushansky, S. Mikolajczak, 2013, Cell Death and Disease.

Humanized Mouse Models for the Study of Human Malaria Parasite Biology, Pathogenesis, and Immunity

S. Kappe, N. Minkah, Carola Schafer, 2018, Front. Immunol..

Differential transcriptome profiling identifies Plasmodium genes encoding pre‐erythrocytic stage‐specific proteins

S. Kappe, Nelly Camargo, K. Matuschewski, 2004, Molecular microbiology.

Conservation of a Gliding Motility and Cell Invasion Machinery in Apicomplexan Parasites

R. Ménard, S. Kappe, V. Nussenzweig, 1999, The Journal of cell biology.

Model for In Vivo Assessment of Humoral Protection against Malaria Sporozoite Challenge by Passive Transfer of Monoclonal Antibodies and Immune Serum

A. Vaughan, S. Kappe, P. Sinnis, 2013, Infection and Immunity.

Transformation of Sporozoites into Early Exoerythrocytic Malaria Parasites Does Not Require Host Cells

S. Kappe, Nelly Camargo, K. Kaiser, 2003, The Journal of experimental medicine.

A Plasmodium falciparum Cysteine Rich Secretory protein uniquely localizes to one end of male gametes

A. Vaughan, S. Kappe, Sudhir Kumar, 2022, Molecular and Biochemical Parasitology.

Advances and challenges in malaria vaccine development

Joseph D. Smith, S. Kappe, Ruobing Wang, 2009, Expert Reviews in Molecular Medicine.

A family of chimeric erythrocyte binding proteins of malaria parasites.

J. Adams, S. Kappe, P. Blair, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Interrogating the Plasmodium Sporozoite Surface: Identification of Surface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP by Mass Spectrometry-Based Proteomics

Kristian E. Swearingen, R. Moritz, A. Vaughan, 2016, PLoS pathogens.

Plasmodium liver stage developmental arrest by depletion of a protein at the parasite-host interface.

S. Kappe, Nelly Camargo, K. Matuschewski, 2005, Proceedings of the National Academy of Sciences of the United States of America.

A Nondiscriminating Glutamyl-tRNA Synthetase in the Plasmodium Apicoplast

P. Rathod, M. Gardner, S. Kappe, 2013, The Journal of Biological Chemistry.

Perturbations of Plasmodium Puf2 expression and RNA‐seq of Puf2‐deficient sporozoites reveal a critical role in maintaining RNA homeostasis and parasite transmissibility

A. Vaughan, S. Kappe, W. Moon, 2013, Cellular microbiology.

The primase domain of PfPrex is a proteolytically matured, essential enzyme of the apicoplast.

M. Llinás, S. Kappe, J. Keck, 2011, Molecular and biochemical parasitology.

SAP1 is a critical post‐transcriptional regulator of infectivity in malaria parasite sporozoite stages

Xinxia Peng, A. Aly, S. Kappe, 2011, Molecular microbiology.

2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections.

S. Kappe, A. Tarun, M. Zloh, 2010, Bioorganic & medicinal chemistry.

Plasmodium pyruvate dehydrogenase activity is only essential for the parasite's progression from liver infection to blood infection

A. Vaughan, S. Kappe, A. Tarun, 2010, Molecular microbiology.

Genetically engineered, attenuated whole-cell vaccine approaches for malaria

A. Vaughan, S. Kappe, Ruobing Wang, 2010, Human vaccines.

Type II fatty acid synthesis is essential only for malaria parasite late liver stage development

A. Vaughan, A. Aly, S. Kappe, 2008, Cellular microbiology.

Distinct Malaria Parasite Sporozoites Reveal Transcriptional Changes That Cause Differential Tissue Infection Competence in the Mosquito Vector and Mammalian Host

Xinxia Peng, S. Kappe, P. de la Vega, 2008, Molecular and Cellular Biology.

Assessment and improvement of the Plasmodium yoelii yoelii genome annotation through comparative analysis

Ling Li, Xinxia Peng, Gowthaman Ramasamy, 2008, ISMB.

Targeted deletion of SAP1 abolishes the expression of infectivity factors necessary for successful malaria parasite liver infection

I. Coppens, A. Aly, S. Kappe, 2008, Molecular microbiology.

Genetically modified Plasmodium parasites as a protective experimental malaria vaccine

S. Kappe, K. Matuschewski, A. Mueller, 2005, Nature.

Plasmodium sporozoite molecular cell biology.

S. Kappe, C. Buscaglia, V. Nussenzweig, 2004, Annual review of cell and developmental biology.

A member of a conserved Plasmodium protein family with membrane-attack complex/perforin (MACPF)-like domains localizes to the micronemes of sporozoites.

I. Coppens, A. Vaidya, J. Morrisey, 2004, Molecular and biochemical parasitology.

The Plasmodium sporozoite journey: a rite of passage.

S. Kappe, K. Matuschewski, K. Kaiser, 2003, Trends in parasitology.

Erythrocyte-binding activity of Plasmodium yoelii apical membrane antigen-1 expressed on the surface of transfected COS-7 cells.

J. Adams, S. Kappe, D. Narum, 2001, Molecular and biochemical parasitology.

That Was Then But This Is Now: Malaria Research in the Time of an Eradication Agenda

A. Vaughan, S. Kappe, A. Cowman, 2010, Science.

The s48/45 six-cysteine proteins: mediators of interaction throughout the Plasmodium life cycle.

S. Kappe, Silvia A. Arredondo, 2016, International journal for parasitology.

Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites

Kristian E. Swearingen, R. Moritz, S. Kappe, 2019, Nature Communications.

Proteogenomic analysis of the total and surface-exposed proteomes of Plasmodium vivax salivary gland sporozoites

Jetsumon Sattabongkot, Robert L Moritz, Kristian E. Swearingen, 2017, PLoS neglected tropical diseases.

Total and Putative Surface Proteomics of Malaria Parasite Salivary Gland Sporozoites*

Kristian E. Swearingen, R. Moritz, A. Vaughan, 2013, Molecular & Cellular Proteomics.

Depletion of the Plasmodium berghei thrombospondin-related sporozoite protein reveals a role in host cell entry by sporozoites.

S. Kappe, Nelly Camargo, M. Labaied, 2007, Molecular and biochemical parasitology.

Apicomplexan gliding motility and host cell invasion: overhauling the motor model.

I. Coppens, S. Kappe, C. Buscaglia, 2004, Trends in parasitology.

Myosin A tail domain interacting protein (MTIP) localizes to the inner membrane complex of Plasmodium sporozoites

I. Coppens, S. Kappe, V. Nussenzweig, 2003, Journal of Cell Science.

Identification of the class XIV myosins Pb-MyoA and Py-MyoA and expression in Plasmodium sporozoites.

S. Kappe, V. Nussenzweig, K. Matuschewski, 2001, Molecular and biochemical parasitology.

Malaria parasites utilize two essential plasma membrane fusogens for gamete fertilization

A. Vaughan, S. Kappe, Nelly Camargo, 2022, Cellular and Molecular Life Sciences.

Global gene expression of human malaria parasite liver stages throughout intrahepatocytic development

A. Vaughan, S. Kappe, Nelly Camargo, 2023, bioRxiv.

A recombinant antibody against Plasmodium vivax UIS4 for distinguishing replicating from dormant liver stages

S. Kappe, D. Kyle, D. Sather, 2018, Malaria Journal.

A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum

S. Kappe, D. Kyle, C. Andolina, 2018, Nature Communications.

A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite

Alex B. Miller, S. Hoffman, H. Liao, 2018, Nature Medicine.

Malaria Parasite Liver Infection and Exoerythrocytic Biology.

A. Vaughan, S. Kappe, 2017, Cold Spring Harbor perspectives in medicine.

Selection and refinement: the malaria parasite's infection and exploitation of host hepatocytes.

S. Kappe, A. Kaushansky, 2015, Current opinion in microbiology.

Plasmodium vivax liver stage development and hypnozoite persistence in human liver-chimeric mice.

A. Vaughan, S. Kappe, Nelly Camargo, 2015, Cell host & microbe.

Susceptibility to Plasmodium yoelii Preerythrocytic Infection in BALB/c Substrains Is Determined at the Point of Hepatocyte Invasion

M. Gardner, A. Vaughan, S. Kappe, 2014, Infection and Immunity.

Of men in mice: the success and promise of humanized mouse models for human malaria parasite infections

M. Vignali, S. Kappe, A. Kaushansky, 2014, Cellular microbiology.

Complete Plasmodium falciparum liver-stage development in liver-chimeric mice.

A. Vaughan, S. Kappe, Nelly Camargo, 2012, The Journal of clinical investigation.

Host cell transcriptional profiling during malaria liver stage infection reveals a coordinated and sequential set of biological events

Xinxia Peng, S. Kappe, M. Mota, 2009, BMC Genomics.

Heme oxygenase-1 is an anti-inflammatory host factor that promotes murine plasmodium liver infection.

Daniel G. Anderson, S. Kappe, M. Mota, 2008, Cell Host and Microbe.

Multiplex, DNase-free one-step reverse transcription PCR for Plasmodium 18S rRNA and spliced gametocyte-specific mRNAs

J. Kublin, S. Kappe, B. Greenhouse, 2017, Malaria Journal.

Exploring the transcriptome of the malaria sporozoite stage

J. Adams, John Quackenbush, M. Gardner, 2001, Proceedings of the National Academy of Sciences of the United States of America.

A Putative Plasmodium RNA-Binding Protein Plays a Critical Role in Female Gamete Fertility and Parasite Transmission to the Mosquito Vector

A. Vaughan, S. Kappe, Sudhir Kumar, 2022, Frontiers in Cell and Developmental Biology.

Plasmodium falciparum Calcium-Dependent Protein Kinase 4 is Critical for Male Gametogenesis and Transmission to the Mosquito Vector

Kristian E. Swearingen, U. Kusebauch, R. Moritz, 2021, bioRxiv.

Plasmodium falciparum genetic crosses in a humanized mouse model

A. Vaughan, S. Kappe, Nelly Camargo, 2015, Nature Methods.

Plasmodium yoelii Macrophage Migration Inhibitory Factor Is Necessary for Efficient Liver-Stage Development

S. Kappe, S. Mikolajczak, A. Harupa, 2012, Infection and Immunity.

Suppression of host p53 is critical for Plasmodium liver-stage infection.

A. S. Ye, G. MacBeath, A. Vaughan, 2013, Cell reports.

In Vitro Culture, Drug Sensitivity, and Transcriptome of Plasmodium Vivax Hypnozoites.

Vincent L. Butty, Alex B. Miller, S. Bhatia, 2018, Cell host & microbe.

A clash to conquer: the malaria parasite liver infection

S. Kappe, S. Mikolajczak, 2006, Molecular microbiology.

PfCap380 as a marker for Plasmodium falciparum oocyst development in vivo and in vitro

A. Vaughan, S. Kappe, A. Ghosh, 2018, Malaria Journal.

Release of Hepatic Plasmodium yoelii Merozoites into the Pulmonary Microvasculature

S. Kappe, C. Klotz, T. Schnieder, 2007, PLoS pathogens.

Natural Parasite Exposure Induces Protective Human Anti‐Malarial Antibodies

S. Kappe, H. Wardemann, E. Marois, 2017, Immunity.

Author Correction: A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite

Alex B. Miller, S. Hoffman, H. Liao, 2018, Nature Medicine.

cGAS-mediated control of blood-stage malaria promotes Plasmodium-specific germinal center responses.

S. Kappe, D. Sather, M. Gale, 2018, JCI insight.

A Plasmodium yoelii Mei2-Like RNA Binding Protein Is Essential for Completion of Liver Stage Schizogony

A. Vaughan, S. Kappe, Marshall Davis, 2016, Infection and Immunity.

Platelet derived growth factor receptor β (PDGFRβ) is a host receptor for the human malaria parasite adhesin TRAP

Kristian E. Swearingen, R. Moritz, S. Kappe, 2020, Scientific Reports.

Transcriptome and histone epigenome of Plasmodium vivax salivary-gland sporozoites point to tight regulatory control and mechanisms for liver-stage differentiation in relapsing malaria.

Kristian E. Swearingen, R. Moritz, S. Kappe, 2019, International journal for parasitology.

Transcriptome and histone epigenome of Plasmodium vivax salivary-gland sporozoites point to tight regulatory control and potential mechanisms for liver-stage differentiation

Kristian E. Swearingen, R. Moritz, S. Kappe, 2017, bioRxiv.

Whole parasite vaccination approaches for prevention of malaria infection.

A. Vaughan, S. Kappe, J. Harty, 2012, Trends in immunology.

Mechanisms of Stage-Transcending Protection Following Immunization of Mice with Late Liver Stage-Arresting Genetically Attenuated Malaria Parasites

A. Vaughan, S. Kappe, B. Sack, 2015, PLoS pathogens.

A method for the isolation and characterization of functional murine monoclonal antibodies by single B cell cloning.

S. Kappe, D. Sather, V. Vigdorovich, 2017, Journal of immunological methods.

Interferon-mediated innate immune responses against malaria parasite liver stages.

A. Vaughan, S. Kappe, B. Sack, 2014, Cell reports.

Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design

A. Aly, S. Kappe, A. Cowman, 2009, Proceedings of the National Academy of Sciences.

Anti-TRAP/SSP2 monoclonal antibodies can inhibit sporozoite infection and may enhance protection of anti-CSP monoclonal antibodies

S. Kappe, Nelly Camargo, D. Sather, 2022, npj Vaccines.

P. falciparum Enhances HIV Replication in an Experimental Malaria Challenge System

R. Schooley, F. Vaida, S. Kappe, 2012, PloS one.

Subpatent infection with nucleoside transporter 1‐deficient Plasmodium blood stage parasites confers sterile protection against lethal malaria in mice

A. Aly, S. Kappe, Megan J. Downie, 2010, Cellular microbiology.

Plasmodium falciparum Calcium-Dependent Protein Kinase 4 is Critical for Male Gametogenesis and Transmission to the Mosquito Vector

Kristian E. Swearingen, U. Kusebauch, R. Moritz, 2021, mBio.

A Tandem Mass Spectrometry Sequence Database Search Method for Identification of O-Fucosylated Proteins by Mass Spectrometry.

Luis Mendoza, Eric W Deutsch, Robert L Moritz, 2018, Journal of proteome research.

L-FABP is a critical host factor for successful malaria liver stage development.

S. Kappe, Nelly Camargo, Drew Mackellar, 2007, International journal for parasitology.

Susceptibility to Plasmodium liver stage infection is altered by hepatocyte polyploidy

S. Kappe, A. Kaushansky, Laura S. Austin, 2014, Cellular microbiology.

Neuroimmunological Blood Brain Barrier Opening in Experimental Cerebral Malaria

S. Kappe, U. Frevert, S. Mikolajczak, 2012, PLoS pathogens.

Identification of Novel Pre-Erythrocytic Malaria Antigen Candidates for Combination Vaccines with Circumsporozoite Protein

S. Kappe, R. Morrison, P. Duffy, 2016, PloS one.

Cyclic GMP Balance Is Critical for Malaria Parasite Transmission from the Mosquito to the Mammalian Host

A. Vaughan, S. Kappe, S. Mikolajczak, 2015, mBio.

Blood Stage Malaria Disrupts Humoral Immunity to the Pre-erythrocytic Stage Circumsporozoite Protein.

A. Vaughan, S. Kappe, D. Sather, 2016, Cell reports.

Anti-TRAP/SSP2 monoclonal antibodies can inhibit sporozoite infection and may enhance protection of anti-CSP monoclonal antibodies

S. Kappe, Nelly Camargo, D. Sather, 2021, bioRxiv.

Plasmodium yoelii S4/CelTOS is important for sporozoite gliding motility and cell traversal

A. Vaughan, S. Kappe, Nelly Camargo, 2018, Cellular microbiology.

Preerythrocytic malaria vaccine development

A. Aly, S. Kappe, S. Mikolajczak, 2007, Current opinion in infectious diseases.

Real-time quantitative reverse transcription PCR for monitoring of blood-stage Plasmodium falciparum infections in malaria human challenge trials.

S. Kappe, F. Fang, B. Cookson, 2012, The American journal of tropical medicine and hygiene.

Bulk segregant analysis reveals environment × genotype interactions determining malaria parasite growth

A. Vaughan, S. Kappe, Nelly Camargo, 2021 .

A Plasmodium α/β‐hydrolase modulates the development of invasive stages

A. Aly, S. Kappe, H. Kain, 2015, Cellular microbiology.

Optimizing bulk segregant analysis of drug resistance using Plasmodium falciparum genetic crosses conducted in humanized mice

A. Vaughan, S. Kappe, M. Ferdig, 2021, bioRxiv.

The power and promise of genetic mapping from Plasmodium falciparum crosses utilizing human liver-chimeric mice

A. Vaughan, S. Kappe, F. Nosten, 2021, Communications Biology.

The power and promise of genetic mapping from Plasmodium falciparum crosses utilizing human liver-chimeric mice

A. Vaughan, S. Kappe, F. Nosten, 2021, Communications biology.

Genetic engineering of attenuated malaria parasites for vaccination.

S. Kappe, C. Janse, Shahid M. Khan, 2012, Current opinion in biotechnology.

Malaria liver stage culture: in vitro veritas?

S. Kappe, P. Duffy, 2006, The American journal of tropical medicine and hygiene.

PfHMGB2 has a role in malaria parasite mosquito infection

S. Kappe, Sudhir Kumar, 2022, Frontiers in Cellular and Infection Microbiology.

Erythrocyte binding protein homologues of rodent malaria parasites.

J. Adams, S. Kappe, G. Curley, 1997, Molecular and biochemical parasitology.

Plasmodium vivax latent liver infection is characterized by persistent hypnozoites, hypnozoite-derived schizonts, and time-dependent efficacy of primaquine

S. Kappe, W. Roobsoong, S. Mikolajczak, 2022, Molecular therapy. Methods & clinical development.

Quantitative isolation and in vivo imaging of malaria parasite liver stages.

S. Kappe, A. Tarun, R. Dumpit, 2006, International journal for parasitology.

Plasmodium vivax Latent Liver Stage Infection and Relapse: Biological Insights and New Experimental Tools.

A. Vaughan, S. Kappe, C. Schäfer, 2021, Annual review of microbiology.

Safety and Comparability of Controlled Human Plasmodium falciparum Infection by Mosquito Bite in Malaria-Naïve Subjects at a New Facility for Sporozoite Challenge

J. Kublin, S. Kappe, P. Gilbert, 2014, PloS one.

Malaria parasite pre‐erythrocytic infection: preparation meets opportunity

S. Kappe, S. Lindner, Jessica L. Miller, 2012, Cellular microbiology.

Secretory Organelle Function in the Plasmodium Sporozoite.

S. Kappe, Silvia A. Arredondo, Antonino Schepis, 2021, Trends in parasitology.

An Opsonic Phagocytosis Assay for Plasmodium falciparum Sporozoites

S. Kappe, M. Navarro, B. Sack, 2016, Clinical and Vaccine Immunology.

A Randomized Trial Evaluating the Prophylactic Activity of DSM265 Against Preerythrocytic Plasmodium falciparum Infection During Controlled Human Malarial Infection by Mosquito Bites and Direct Venous Inoculation

J. Kublin, S. Kappe, Y. Fong, 2018, The Journal of infectious diseases.

In vitro production of infectious Plasmodium falciparum sporozoites

S. Hoffman, A. Aly, S. Kappe, 2022, Nature.

Disruption of the Plasmodium falciparum liver‐stage antigen‐1 locus causes a differentiation defect in late liver‐stage parasites

S. Kappe, A. Cowman, P. de la Vega, 2011, Cellular microbiology.

Infectivity-associated Changes in the Transcriptional Repertoire of the Malaria Parasite Sporozoite Stage*

Stuart M. Brown, S. Kappe, V. Nussenzweig, 2002, The Journal of Biological Chemistry.

Kinetic Flux Profiling Elucidates Two Independent Acetyl-CoA Biosynthetic Pathways in Plasmodium falciparum*

Manuel Llinás, David H Perlman, M. Llinás, 2013, The Journal of Biological Chemistry.

Superior antimalarial immunity after vaccination with late liver stage-arresting genetically attenuated parasites.

A. Vaughan, A. Aly, S. Kappe, 2011, Cell host & microbe.

Type II Fatty Acid Biosynthesis Is Essential for Plasmodium falciparum Sporozoite Development in the Midgut of Anopheles Mosquitoes

S. Hoffman, S. Hoffman, A. Vaughan, 2013, Eukaryotic Cell.

Protracted sterile protection with Plasmodium yoelii pre-erythrocytic genetically attenuated parasite malaria vaccines is independent of significant liver-stage persistence and is mediated by CD8+ T cells.

S. Kappe, A. Tarun, R. Dumpit, 2007, The Journal of infectious diseases.

Enzymes involved in plastid‐targeted phosphatidic acid synthesis are essential for Plasmodium yoelii liver‐stage development

R. Moritz, A. Vaughan, S. Kappe, 2014, Molecular microbiology.

PfSRPK1 Regulates Asexual Blood Stage Schizogony and Is Essential for Male Gamete Formation

A. Vaughan, S. Kappe, V. Baranwal, 2022, Microbiology spectrum.

A recombinant antibody against Plasmodium vivax UIS4 for distinguishing replicating from dormant liver stages

S. Kappe, D. Kyle, D. Sather, 2018, Malaria Journal.

Novel approaches to whole sporozoite vaccination against malaria✩

S. Kappe, B. Mordmüller, B. Sack, 2015, Vaccine.

First-in-human evaluation of genetically attenuated Plasmodium falciparum sporozoites administered by bite of Anopheles mosquitoes to adult volunteers.

S. Kappe, A. Cowman, P. de la Vega, 2013, Vaccine.

Malaria parasite liver stages.

S. Kappe, N. Minkah, Debashree Goswami, 2021, Journal of hepatology.

A next-generation genetically attenuated Plasmodium falciparum parasite created by triple gene deletion.

S. Kappe, A. Cowman, Nelly Camargo, 2014, Molecular therapy : the journal of the American Society of Gene Therapy.

Plasmodium yoelii Sporozoites with Simultaneous Deletion of P52 and P36 Are Completely Attenuated and Confer Sterile Immunity against Infection

I. Coppens, S. Kappe, R. Dumpit, 2007, Infection and Immunity.

Th1-like Plasmodium-Specific Memory CD4+ T Cells Support Humoral Immunity.

A. Vaughan, S. Kappe, R. Vijay, 2018, Cell reports.

Human Antibodies that Slow Erythrocyte Invasion Potentiate Malaria-Neutralizing Antibodies

S. Kappe, C. Robinson, P. Gilson, 2019, Cell.

Plasmodium falciparum PF10_0164 (ETRAMP10.3) Is an Essential Parasitophorous Vacuole and Exported Protein in Blood Stages

A. Aly, S. Kappe, A. Cowman, 2010, Eukaryotic Cell.

Plasmodium falciparum MAEBL is a unique member of the ebl family.

S. Kappe, P. Blair, J. Adams, 2002, Molecular and biochemical parasitology.

Redefining the role of de novo fatty acid synthesis in Plasmodium parasites.

A. Vaughan, S. Kappe, A. Tarun, 2009, Trends in parasitology.

A systematic analysis of the early transcribed membrane protein family throughout the life cycle of Plasmodium yoelii

A. Vaughan, A. Aly, S. Kappe, 2011, Cellular microbiology.

Genetically modified Plasmodium parasites as a protective experimental malaria vaccine

S. Kappe, K. Matuschewski, A. Mueller, 2007, Nature.

Plasmodium 18S rRNA of intravenously administered sporozoites does not persist in peripheral blood

S. Hoffman, S. Kappe, R. Seder, 2018, Malaria Journal.

Malaria's Stealth Shuttle

S. Kappe, A. Cowman, 2006, Science.

Characterization of Plasmodium vivax Proteins in Plasma-Derived Exosomes From Malaria-Infected Liver-Chimeric Humanized Mice

J. González, S. Kappe, H. D. del Portillo, 2018, Front. Microbiol..

Transmission of malaria to mosquitoes blocked by bumped kinase inhibitors.

Steven M. Johnson, Dustin J Maly, C. Verlinde, 2012, The Journal of clinical investigation.

Immunization with genetically attenuated P. falciparum parasites induces long-lived antibodies that efficiently block hepatocyte invasion by sporozoites.

S. Kappe, A. Kaushansky, Ruobing Wang, 2014, Vaccine.

A transgenic Plasmodium falciparum NF54 strain that expresses GFP-luciferase throughout the parasite life cycle.

A. Vaughan, S. Kappe, Nelly Camargo, 2012, Molecular and biochemical parasitology.

Plasmodium falciparum CRK5 Is Critical for Male Gametogenesis and Infection of the Mosquito

S. Kappe, Sudhir Kumar, Olivia R. Gargaro, 2022, mBio.

Plasmodium 18S Ribosomal RNA Biomarker Clearance After Food and Drug Administration–Approved Antimalarial Treatment in Controlled Human Malaria Infection Trials

S. Hoffman, J. Kublin, S. Kappe, 2023, Open forum infectious diseases.

Complete attenuation of genetically engineered Plasmodium falciparum sporozoites in human subjects

J. Kublin, A. Vaughan, S. Kappe, 2017, Science Translational Medicine.

Development of a quantitative flow cytometry-based assay to assess infection by Plasmodium falciparum sporozoites.

S. Kappe, A. Kaushansky, Nastaran Rezakhani, 2012, Molecular and biochemical parasitology.

Another Shot at a Malaria Vaccine

S. Kappe, S. Mikolajczak, 2011, Science.

Chloroquine resistance evolution in Plasmodium falciparum is mediated by the putative amino acid transporter AAT1

D. Conway, R. Pearson, A. Vaughan, 2023, Nature Microbiology.

An amino acid transporter AAT1 plays a pivotal role in chloroquine resistance evolution in malaria parasites

D. Kwiatkowski, D. Conway, R. Pearson, 2022, bioRxiv.

A Global Survey of ATPase Activity in Plasmodium falciparum Asexual Blood Stages and Gametocytes*

Richard D. Smith, S. Kappe, B. Webb-Robertson, 2017, Molecular & Cellular Proteomics.

Plasmodium microtubule-binding protein EB1 is critical for partitioning of nuclei in male gametogenesis

S. Kappe, Nelly Camargo, Sudhir Kumar, 2023, mBio.

Sporozoite immunization: innovative translational science to support the fight against malaria

Joana C. Silva, S. Hoffman, A. Dicko, 2023, Expert review of vaccines.

ELQ-331 as a prototype for extremely durable chemoprotection against malaria

S. Kappe, D. Koop, L. Bleyle, 2019, Malaria Journal.

A dispensable Plasmodium locus for stable transgene expression.

A. Vaughan, S. Kappe, S. Mikolajczak, 2010, Molecular and biochemical parasitology.

sporozoite development in the midgut of Anopheles mosquitoes 2

S. Hoffman, A. Vaughan, S. Kappe, 2013 .

Interferon-mediated innate immune responses against malaria parasite liver stages.

A. Vaughan, S. Kappe, B. Sack, 2014, Cell reports.

Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection

G. Superti-Furga, S. Kappe, M. Mota, 2013, Nature Medicine.

A specific inhibitor of PfCDPK4 blocks malaria transmission: chemical-genetic validation.

Dustin J Maly, X. Su, K. Comess, 2014, The Journal of infectious diseases.

Infection Plasmodium against Liver Stage Cd40 Is Required for Protective Immunity

A. Vaughan, S. Kappe, I. Mohar, 2022 .

Heme oxygenase-1 is an anti-inflammatory host factor that promotes murine plasmodium liver infection.

Daniel G. Anderson, S. Kappe, M. Mota, 2008, Cell host & microbe.

Plasmodium yoelii inhibitor of cysteine proteases is exported to exomembrane structures and interacts with yoelipain‐2 during asexual blood‐stage development

A. Vaughan, S. Kappe, S. Lindner, 2013, Cellular microbiology.

The crucial role of hepatocyte growth factor receptor during liver-stage infection is not conserved among Plasmodium species

S. Kappe, A. Kaushansky, 2011, Nature Medicine.

Alterations in Phosphorylation of Hepatocyte Ribosomal Protein S6 Control Plasmodium Liver Stage Infection.

Elizabeth K. K. Glennon, S. Kappe, Fred D. Mast, 2019, Cell reports.

A next-generation genetically attenuated Plasmodium falciparum parasite created by triple gene deletion.

S. Kappe, A. Cowman, Nelly Camargo, 2014, Molecular therapy : the journal of the American Society of Gene Therapy.

Susceptibility to Plasmodium yoelii Preerythrocytic Infection in BALB/c Substrains Is Determined at the Point of Hepatocyte Invasion

M. Gardner, A. Vaughan, S. Kappe, 2014, Infection and Immunity.

Plasmodium GPI-anchored micronemal antigen is essential for parasite transmission through the mosquito host.

Kristian E. Swearingen, A. Vaughan, S. Kappe, 2023, Molecular microbiology.

A Plasmodium yoelii Mei2-Like RNA Binding Protein Is Essential for Completion of Liver Stage Schizogony

A. Vaughan, S. Kappe, Marshall Davis, 2016, Infection and Immunity.

A Plasmodium falciparum genetic cross reveals the contributions of pfcrt and plasmepsin II/III to piperaquine drug resistance

A. Vaughan, S. Kappe, M. Ferdig, 2023, bioRxiv.

Type II fatty acid synthesis is essential only for malaria parasite late liver stage development

A. Vaughan, A. Aly, S. Kappe, 2008, Cellular Microbiology.

Transformation of Sporozoites into Early Exoerythrocytic Malaria Parasites Does Not Require Host Cells

S. Kappe, Nelly Camargo, K. Kaiser, 2003, The Journal of experimental medicine.

A replication competent Plasmodium falciparum parasite completely attenuated by dual gene deletion

A. Vaughan, S. Kappe, Nelly Camargo, 2024, EMBO molecular medicine.

Malaria blood stage infection suppresses liver stage infection via host-induced interferons but not hepcidin

S. Kappe, Nelly Camargo, N. Minkah, 2024, Nature communications.

A genetically attenuated parasite vaccine does not require liver stage persistence to elicit sterile protective immunity against sporozoite-induced malaria in mice.

A. Vaughan, S. Kappe, S. Mikolajczak, 2010, The Journal of infectious diseases.