J. Cumming

发表

Effects of camptothecin, a topoisomerase I inhibitor, on Plasmodium falciparum.

A. Bodley, J. Cumming, T. Shapiro, 1998, Biochemical pharmacology.

Rational design of novel, potent piperazinone and imidazolidinone BACE1 inhibitors.

A. Stamford, J. Cumming, L. Zhang, 2008, Bioorganic & medicinal chemistry letters.

Structure based design of iminohydantoin BACE1 inhibitors: identification of an orally available, centrally active BACE1 inhibitor.

Lynn A. Hyde, W. Greenlee, A. Stamford, 2012, Bioorganic & medicinal chemistry letters.

Orally active antimalarial 3-substituted trioxanes: new synthetic methodology and biological evaluation.

J. Cumming, T. Shapiro, S. Woo, 1998, Journal of medicinal chemistry.

Antimalarial 1,2,4-Trioxanes Related to Artemisinin: Rules for Assignment of Relative Stereochemistry in Diversely Substituted Analogs

J. Cumming, G. Posner, C. Oh, 1997 .

Trioxane dimers have potent antimalarial, antiproliferative and antitumor activities in vitro.

J. Cumming, T. Shapiro, T. Kensler, 1997, Bioorganic & medicinal chemistry.

Unprecedented Reversal of Regioselectivity during Methanolysis and an Interception of Curtius Rearrangement

A. Stamford, J. Cumming, P. Orth, 2021, European Journal of Organic Chemistry.

Synthesis and in vitro antimalarial activity of sulfone endoperoxides.

J. Cumming, T. Shapiro, G. Posner, 1998, Bioorganic & medicinal chemistry letters.

Design, synthesis, derivatization, and structure-activity relationships of simplified, tricyclic, 1,2,4-trioxane alcohol analogues of the antimalarial artemisinin.

J. Cumming, T. Shapiro, G. Posner, 1998, Journal of medicinal chemistry.

STimulator of INterferon Genes Agonism Accelerates Antitumor Activity in Poorly Immunogenic Tumors

J. Cumming, Sarah Javaid, A. Tse, 2021, Molecular Cancer Therapeutics.

Discovery and Optimization of Rationally Designed Bicyclic Inhibitors of Human Arginase to Enhance Cancer Immunotherapy.

Theodore A. Martinot, J. O'neil, J. Cumming, 2020, ACS medicinal chemistry letters.

Synthesis and antimalarial activity of heteroatom-containing bicyclic endoperoxides

J. Cumming, T. Shapiro, G. Posner, 1997 .

Antimalarially potent, easily prepared, fluorinated endoperoxides

J. Cumming, T. Shapiro, G. Posner, 1996 .

Mechanism-based design of simple, symmetrical, easily prepared, potent antimalarial endoperoxides

J. Cumming, T. Shapiro, G. Posner, 1996 .

Potent pyrrolidine- and piperidine-based BACE-1 inhibitors.

A. Stamford, J. Cumming, C. Strickland, 2008, Bioorganic & medicinal chemistry letters.

Antimalarial activity of artemisinin (qinghaosu) and related trioxanes: mechanism(s) of action.

J. Cumming, G. Posner, P. Ploypradith, 1997, Advances in pharmacology.

Evidence for Fe(IV):O in the Molecular Mechanism of Action of the Trioxane Antimalarial Artemisinin

Poonsakdi Ploypradith, Chang Ho Oh, J. Cumming, 1995 .

EVIDENCE FOR THE IMPORTANCE OF HIGH-VALENT FE=O AND OF A DIKETONE IN THE MOLECULAR MECHANISM OF ACTION OF ANTIMALARIAL TRIOXANE ANALOGS OF ARTEMISININ

J. Cumming, T. Shapiro, G. Posner, 1996 .

Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer.

Andrew M Haidle, Matthew L. Maddess, J. Cumming, 2022, Journal of medicinal chemistry.

A kinase-cGAS cascade to synthesize a therapeutic STING activator

Steven P. Miller, Paul N. Devine, Matthew L. Maddess, 2022, Nature.

Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)-A β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer's Disease.

Qin Jiang, William J Greenlee, Xia Chen, 2016, Journal of medicinal chemistry.

Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors.

Theodore A. Martinot, J. Cumming, A. Palani, 2021, ACS medicinal chemistry letters.

Stereoselective Synthesis of 7R-Paeonimetabol ine-I; Stereoselective Route Towards Paeoniflorigenon e

Thomas E. Smith, J. Cumming, N. Raoof, 1997 .

BACE1 – but not BACE2 – function is critical for metabolic disorders induced by high-fat diets in C57BL/6N mice

Lynn A. Hyde, T. Sorg, J. Cumming, 2021, bioRxiv.

The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer’s disease patients

Michael Tanen, Matthew E. Kennedy, Wei Li, 2016, Science Translational Medicine.

Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization.

Andrew Stamford, William Greenlee, Guoqing Li, 2010, Bioorganic & medicinal chemistry letters.

Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology

J. O'neil, J. Cumming, A. Palani, 2021, ACS medicinal chemistry letters.

An orally available non-nucleotide STING agonist with antitumor activity

Andrew M Haidle, J. Cumming, I. Kariv, 2020, Science.

Further evidence supporting the importance of and the restrictions on a carbon-centered radical for high antimalarial activity of 1,2,4-trioxanes like artemisinin.

A. Bodley, J. Cumming, T. Shapiro, 1995, Journal of medicinal chemistry.

Design and validation of bicyclic iminopyrimidinones as beta amyloid cleaving enzyme-1 (BACE1) inhibitors: conformational constraint to favor a bioactive conformation.

William Greenlee, Lynn Hyde, Xia Chen, 2012, Journal of medicinal chemistry.

Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor that Affords Robust CNS Aβ Reduction.

Suresh Babu, William J Greenlee, Xia Chen, 2012, ACS medicinal chemistry letters.

Design and development of BACE-1 inhibitors.

J. Cumming, U. Iserloh, M. Kennedy, 2004, Current opinion in drug discovery & development.

Structure-Based Design of an Iminoheterocyclic β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aβ in Nonhuman Primates.

Lynn A. Hyde, W. Greenlee, A. Stamford, 2016, Journal of medicinal chemistry.

Antimalarial sulfone trioxanes

J. Cumming, T. Shapiro, G. Posner, 1998 .

Peptidomimetic BACE1 Inhibitors for Treatment of Alzheimer's Disease: Design and Evolution

J. Cumming, U. Iserloh, 2011 .

Discovery of cyclic acylguanidines as highly potent and selective beta-site amyloid cleaving enzyme (BACE) inhibitors: Part I--inhibitor design and validation.

Lingyan Wang, Andrew Stamford, Michael Czarniecki, 2010, Journal of medicinal chemistry.

Antimalarial cyclic peroxy ketals.

J. Cumming, T. Shapiro, G. Posner, 1998, Journal of Medicinal Chemistry.

Modeling a Crowdsourced Definition of Molecular Complexity

Robert P. Sheridan, Edward C. Sherer, Charlie Chang, 2014, J. Chem. Inf. Model..

Overcoming Time-Dependent Inhibition (TDI) of Cytochrome P450 3A4 (CYP3A4) Resulting from Bioactivation of a Fluoropyrimidine Moiety.

Lynn A. Hyde, A. Stamford, J. Cumming, 2018, Journal of medicinal chemistry.

A novel domino reaction for the preparation of substituted non-racemic β-proline derivatives

Jeffrey T. Kuethe, Jinsong Hao, J. Cumming, 2016 .