J. Wiesner

发表

The Methylerythritol Phosphate Pathway Is Functionally Active in All Intraerythrocytic Stages of Plasmodium falciparum*

M. Cassera, F. Gozzo, F. L. D’Alexandri, 2004, Journal of Biological Chemistry.

The plastid-like organelle of apicomplexan parasites as drug target.

J. Wiesner, H. Jomaa, A. Reichenberg, 2008, Current pharmaceutical design.

Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs.

H. Lichtenthaler, J. Wiesner, H. Jomaa, 1999, Science.

Antimicrobial peptides: The ancient arm of the human immune system

J. Wiesner, A. Vilcinskas, 2010, Virulence.

Therapeutic Potential of Anti-Microbial Peptides from Insects

J. Wiesner, A. Vilcinskas, 2011 .

Synthesis of the antimalarial drug FR900098 utilizing the nitroso-ene reaction.

A. A. Fokin, J. Wiesner, H. Jomaa, 2007, Organic letters.

Antimicrobial Peptides Expressed in Medicinal Maggots of the Blow Fly Lucilia sericata Show Combinatorial Activity against Bacteria

J. Wiesner, A. Vilcinskas, H. Vogel, 2015, Antimicrobial Agents and Chemotherapy.

Insect antimicrobial peptides show potentiating functional interactions against Gram-negative bacteria

J. Wiesner, R. Twyman, P. Schmid-Hempel, 2015, Proceedings of the Royal Society B: Biological Sciences.

Strategies for the construction of insect P450 fusion enzymes

J. Wiesner, A. Vilcinskas, L. Talmann, 2017, Zeitschrift fur Naturforschung. C, Journal of biosciences.

Identification of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gammadelta T cells in Escherichia coli.

J. Wiesner, H. Jomaa, A. Reichenberg, 2001, FEBS letters.

Isoprenoid biosynthesis of the apicoplast as drug target.

J. Wiesner, H. Jomaa, 2007, Current drug targets.

Harmonine, a defence compound from the harlequin ladybird, inhibits mycobacterial growth and demonstrates multi-stage antimalarial activity

J. Wiesner, R. Fischer, A. Vilcinskas, 2011, Biology Letters.

Determines Chloroquine Uptake in Plasmodium falciparum

J. Wiesner, M. Gekle, L. Grosse-Wortmann, 1998 .

In Vitro Antimicrobial Efficacy of Tobramycin Against Staphylococcus aureus Biofilms in Combination With or Without DNase I and/or Dispersin B: A Preliminary Investigation.

J. Wiesner, A. Vilcinskas, Dulantha Ulluwishewa, 2017, Microbial drug resistance.

Maggot excretion products from the blowfly Lucilia sericata contain contact phase/intrinsic pathway-like proteases with procoagulant functions

K. Preissner, J. Wiesner, A. Vilcinskas, 2015, Thrombosis and Haemostasis.

New antimalarial drugs.

Jochen Wiesner, J. Wiesner, H. Jomaa, 2003, Angewandte Chemie.

Synthesis of α-aryl-substituted and conformationally restricted fosmidomycin analogues as promising antimalarials

J. Wiesner, H. Jomaa, R. Busson, 2006 .

In Vitro and In Vivo Synergy of Fosmidomycin, a Novel Antimalarial Drug, with Clindamycin

J. Wiesner, H. Jomaa, E. Beck, 2002, Antimicrobial Agents and Chemotherapy.

Antimalarial activity of n(6)-substituted adenosine derivatives (part 2).

J. Wiesner, H. Jomaa, A. Link, 2002, Journal of combinatorial chemistry.

[Benzo[c][2,7]naphthyridine-5-yl-amines and benzo[h][1,6]naphthyridine-5-yl-amines--potential antimalarials].

J. Wiesner, H. Jomaa, P. Jones, 2007, Die Pharmazie.

Acyloxyalkyl ester prodrugs of FR900098 with improved in vivo anti-malarial activity.

J. Wiesner, H. Jomaa, A. Reichenberg, 2003, Bioorganic & medicinal chemistry letters.

Alkoxycarbonyloxyethyl Ester Prodrugs of FR900098 with Improved In Vivo Antimalarial Activity

J. Wiesner, H. Jomaa, A. Reichenberg, 2005, Archiv der Pharmazie.

Synthesis and evaluation of α,β-unsaturated α-aryl-substituted fosmidomycin analogues as DXR inhibitors

J. Wiesner, H. Jomaa, J. V. D. Eycken, 2007 .

Divergent strategy for the synthesis of α-aryl-substituted fosmidomycin analogues

J. Wiesner, H. Jomaa, J. Rozenski, 2007 .

Synthesis of alpha-substituted fosmidomycin analogues as highly potent Plasmodium falciparum growth inhibitors.

J. Wiesner, H. Jomaa, S. van Calenbergh, 2006, Bioorganic & medicinal chemistry letters.

Crystal Structure of 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase, a Crucial Enzyme in the Non-mevalonate Pathway of Isoprenoid Biosynthesis*

Gerhard Klebe, Klaus Reuter, Jochen Wiesner, 2002, The Journal of Biological Chemistry.

Towards New Antimalarial Drugs: Synthesis of Non‐Hydrolyzable Phosphate Mimics as Feed for a Predictive QSAR Study on 1‐Deoxy‐D‐xylulose‐5‐phosphate Reductoisomerase Inhibitors

J. Wiesner, H. Jomaa, A. Reichenberg, 2008, Chemistry & biodiversity.

Profiling antimicrobial peptides from the medical maggot Lucilia sericata as potential antibiotics for MDR Gram-negative bacteria

J. Wiesner, A. Vilcinskas, A. Bauer, 2018, The Journal of antimicrobial chemotherapy.

Antimalarial activity of N(6)-substituted adenosine derivatives. Part 3.

J. Wiesner, H. Jomaa, S. van Calenbergh, 2004, Bioorganic & medicinal chemistry.

Anti-malarial activity of N(6)-substituted adenosine derivatives. Part I.

J. Wiesner, H. Jomaa, A. Link, 2002, Bioorganic & medicinal chemistry.

Antimalarial activity of extracts of Abutilon grandiﬂorum G. Don – a traditional Tanzanian medicinal plant

J. Wiesner, M. Heinrich, M. Lanzer, 2004, Phytotherapy research : PTR.

Development of Benzophenone‐Based Farnesyltransferase Inhibitors as Novel Antimalarials

Gerhard Klebe, Katrin Silber, Alexander Hillebrecht, 2008, ChemMedChem.

Non-thiol farnesyltransferase inhibitors: N-(4-aminoacylamino-3-benzoylphenyl)-3-[5-(4-nitrophenyl)-2 furyl]acrylic acid amides and their antimalarial activity.

G. Klebe, J. Wiesner, H. Jomaa, 2005, European journal of medicinal chemistry.

The plastid-derived organelle ofprotozoan human parasites asa target of established and emerging drugs

J. Wiesner, F. Seeber, 2005, Expert opinion on therapeutic targets.

LytB protein catalyzes the terminal step of the 2‐C‐methyl‐D‐erythritol‐4‐phosphate pathway of isoprenoid biosynthesis

J. Wiesner, H. Jomaa, A. Reichenberg, 2002, FEBS letters.

Fosmidomycin, a Novel Chemotherapeutic Agent for Malaria

Jochen Wiesner, J. Wiesner, H. Jomaa, 2003, Antimicrobial Agents and Chemotherapy.

Structure of (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate reductase, the terminal enzyme of the non-mevalonate pathway.

E. Oldfield, J. Wiesner, H. Jomaa, 2008, Journal of the American Chemical Society.

Paramagnetic intermediates of (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase (GcpE/IspG) under steady-state and pre-steady-state conditions.

J. Wiesner, H. Jomaa, B. Hoffman, 2010, Journal of the American Chemical Society.

Reconstitution of an apicoplast‐localised electron transfer pathway involved in the isoprenoid biosynthesis of Plasmodium falciparum

Matthias Pfeiffer, Jochen Wiesner, Frank Seeber, 2005, FEBS letters.

Microbial isoprenoid biosynthesis and human γδ T cell activation

J. Wiesner, H. Jomaa, A. Reichenberg, 2003, FEBS letters.

Analysis of the Isoprenoid Biosynthesis Pathways in Listeria monocytogenes Reveals a Role for the Alternative 2-C-Methyl-d-Erythritol 4-Phosphate Pathway in Murine Infection

J. Wiesner, H. Jomaa, C. Hill, 2008, Infection and Immunity.

Biology of giant proteins of Plasmodium: resolution on polyacrylamide-agarose composite gels.

J. Wiesner, A. Scherf, M. Lanzer, 1998, Parasitology today.

Accumulation of a potent γδ T‐cell stimulator after deletion of the lytB gene in Escherichia coli

J. Wiesner, H. Jomaa, A. Reichenberg, 2002, Immunology.

GcpE Is Involved in the 2-C-Methyl-d-Erythritol 4-Phosphate Pathway of Isoprenoid Biosynthesis in Escherichia coli

J. Wiesner, H. Jomaa, S. Sanderbrand, 2001, Journal of bacteriology.

Synthesis and biological evaluation of cyclopropyl analogues of fosmidomycin as potent Plasmodium falciparum growth inhibitors.

J. Wiesner, H. Jomaa, S. van Calenbergh, 2006, Journal of medicinal chemistry.

Isoprenoid Pigments in Representatives of the Family Microbacteriaceae

J. Wiesner, H. Jomaa, M. Hintz, 2005, Microbiology.

Inhibition of the Non-Mevalonate 1-Deoxy-ᴅ-xylulose-5-phosphate Pathway of Plant Isoprenoid Biosynthesis by Fosmidomycin

J. Schwender, H. Lichtenthaler, J. Wiesner, 1998 .

Expression of var genes located within polymorphic subtelomeric domains of Plasmodium falciparum chromosomes

A. Camargo, J. Wiesner, S. Wünsch, 1997, Molecular and cellular biology.

Fosmidomycin plus Clindamycin for Treatment of Pediatric Patients Aged 1 to 14 Years with Plasmodium falciparum Malaria

J. Wiesner, H. Jomaa, A. Adegnika, 2006, Antimicrobial Agents and Chemotherapy.

Short-Course Regimens of Artesunate-Fosmidomycin in Treatment of Uncomplicated Plasmodium falciparum Malaria

J. Wiesner, H. Jomaa, A. Adegnika, 2005, Antimicrobial Agents and Chemotherapy.

Fosmidomycin for malaria

Jochen Wiesner, J. Wiesner, H. Jomaa, 2002, The Lancet.

Identification of (E)‐4‐hydroxy‐3‐methyl‐but‐2‐enyl pyrophosphate as a major activator for human γδ T cells in Escherichia coli

J. Wiesner, H. Jomaa, A. Reichenberg, 2001 .

Structure-activity relationships of novel anti-malarial agents. Part 2: cinnamic acid derivatives.

J. Wiesner, H. Jomaa, M. Schlitzer, 2001, Bioorganic & medicinal chemistry letters.

Two c-type lysozymes boost the innate immune system of the invasive ladybird Harmonia axyridis.

J. Wiesner, A. Vilcinskas, H. Vogel, 2015, Developmental and comparative immunology.

Tools for discovery of inhibitors of the 1-deoxy-D-xylulose 5-phosphate (DXP) synthase and DXP reductoisomerase: an approach with enzymes from the pathogenic bacterium Pseudomonas aeruginosa.

J. Wiesner, H. Jomaa, S. Sanderbrand, 2000, FEMS microbiology letters.

Farnesyltransferase inhibitors inhibit the growth of malaria parasites in vitro and in vivo.

G. Klebe, J. Wiesner, H. Jomaa, 2004, Angewandte Chemie.

Lucimycin, an antifungal peptide from the therapeutic maggot of the common green bottle fly Lucilia sericata

J. Wiesner, A. Vilcinskas, H. Vogel, 2014, Biological chemistry.

Fosmidomycin for the treatment of malaria

J. Wiesner, H. Jomaa, S. Borrmann, 2003, Parasitology Research.

A Jonah-like chymotrypsin from the therapeutic maggot Lucilia sericata plays a role in wound debridement and coagulation.

K. Preissner, J. Wiesner, A. Vilcinskas, 2016, Insect biochemistry and molecular biology.

Fosmidomycin Uptake into Plasmodium and Babesia-Infected Erythrocytes Is Facilitated by Parasite-Induced New Permeability Pathways

D. Roos, J. Wiesner, H. Jomaa, 2011, PloS one.

Double Ester Prodrugs of FR900098 Display Enhanced In‐Vitro Antimalarial Activity

J. Wiesner, H. Jomaa, M. Schlitzer, 2007, Archiv der Pharmazie.

Fosmidomycin-clindamycin for Plasmodium falciparum Infections in African children.

J. Wiesner, H. Jomaa, A. Adegnika, 2004, The Journal of infectious diseases.

Differential Stimulation of the Na+/H+ Exchanger Determines Chloroquine Uptake in Plasmodium falciparum

J. Wiesner, M. Gekle, L. Grosse-Wortmann, 1998, The Journal of cell biology.

Methods to identify enzymes that degrade the main extracellular polysaccharide component of Staphylococcus epidermidis biofilms

J. Wiesner, A. Vilcinskas, Anke Gökçen, 2013, Virulence.

LytB, a novel gene of the 2‐C‐methyl‐D‐erythritol 4‐phosphate pathway of isoprenoid biosynthesis in Escherichia coli

J. Wiesner, H. Jomaa, B. Altincicek, 2001, FEBS letters.

Functional characterization of GcpE, an essential enzyme of the non‐mevalonate pathway of isoprenoid biosynthesis

J. Wiesner, H. Jomaa, A. Reichenberg, 2002, FEBS letters.

Structure of the (E)‐4‐hydroxy‐3‐methyl‐but‐2‐enyl‐diphosphate reductase from Plasmodium falciparum

J. Wiesner, H. Jomaa, E. Warkentin, 2013, FEBS letters.

Possible direct involvement of the active‐site [4Fe–4S] cluster of the GcpE enzyme from Thermus thermophilus in the conversion of MEcPP

J. Wiesner, H. Jomaa, E. Duin, 2007, FEBS letters.

Structure of the E‐1‐hydroxy‐2‐methyl‐but‐2‐enyl‐4‐diphosphate synthase (GcpE) from Thermus thermophilus

J. Wiesner, H. Jomaa, E. Warkentin, 2011, FEBS letters.

Synthesis of β- and γ-oxa isosteres of fosmidomycin and FR900098 as antimalarial candidates

J. Wiesner, H. Jomaa, M. Schlitzer, 2008 .

Synthesis of beta- and gamma-oxa isosteres of fosmidomycin and FR900098 as antimalarial candidates.

J. Wiesner, H. Jomaa, M. Schlitzer, 2008, Bioorganic & medicinal chemistry.

Synthesis of α-Substituted Fosmidomycin Analogues as Highly Potent Plasmodium falciparum Growth Inhibitors.

J. Wiesner, H. Jomaa, J. Goeman, 2006 .

Diaryl ester prodrugs of FR900098 with improved in vivo antimalarial activity.

J. Wiesner, H. Jomaa, A. Reichenberg, 2001, Bioorganic & medicinal chemistry letters.

RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA.

J. Wiesner, H. Jomaa, A. Mankin, 2010, Journal of the American Chemical Society.

Studies Addressing the Importance of Charge in the Binding of Fosmidomycin‐Like Molecules to Deoxyxylulosephosphate Reductoisomerase

G. Klebe, J. Wiesner, H. Jomaa, 2008, ChemMedChem.

Fosmidomycin as an Antimalarial Agent

J. Wiesner, H. Jomaa, A. Reichenberg, 2012 .

Plasmodium falciparum: detection of the deoxyxylulose 5-phosphate reductoisomerase activity.

J. Wiesner, H. Jomaa, S. Sanderbrand, 2000, Experimental parasitology.

Changes in the transcriptome of the malaria parasite Plasmodium falciparum during the initial phase of transmission from the human to the mosquito

J. Wiesner, R. Fischer, A. Vilcinskas, 2013, BMC Genomics.

Crystallographic structures of two bisphosphonate:1-deoxyxylulose-5-phosphate reductoisomerase complexes.

Shunsuke Yajima, Jochen Wiesner, Eric Oldfield, 2004, Journal of the American Chemical Society.

NMR Studies of DOXP Reductoisomerase and its Inhibitor Complex

H. Schwalbe, J. Wiesner, H. Jomaa, 2011, Chembiochem : a European journal of chemical biology.

Occurrence of nonmevalonate and mevalonate pathways for isoprenoid biosynthesis in bacteria of different taxonomic groups

J. Wiesner, H. Jomaa, M. Hintz, 2005, Microbiology.

FR-900098, an antimalarial development candidate that inhibits the non-mevalonate isoprenoid biosynthesis pathway, shows no evidence of acute toxicity and genotoxicity

J. Wiesner, H. Jomaa, A. Reichenberg, 2016, Virulence.

Expression and characterization of a recombinant i‐type lysozyme from the harlequin ladybird beetle Harmonia axyridis

J. Wiesner, A. Vilcinskas, H. Vogel, 2016, Insect molecular biology.

Seeking new targets for antiparasitic agents.

J. Wiesner, H. Jomaa, S. Sanderbrand, 2001, Trends in parasitology.

1-deoxy-D-xylulose-5-phosphate reductoisomerase

G. Klebe, J. Wiesner, H. Jomaa, 2002 .

Antimicrobial Peptides from Rat-Tailed Maggots of the Drone Fly Eristalis tenax Show Potent Activity against Multidrug-Resistant Gram-Negative Bacteria

J. Wiesner, A. Vilcinskas, H. Vogel, 2020, Microorganisms.

Biological Profiling of Coleoptericins and Coleoptericin-Like Antimicrobial Peptides from the Invasive Harlequin Ladybird Harmonia axyridis.

J. Wiesner, A. Vilcinskas, A. Bauer, 2018, Advances in experimental medicine and biology.

Biofilm-degrading enzymes from Lysobacter gummosus

Jochen Wiesner, Andreas Vilcinskas, J. Wiesner, 2014, Virulence.

Structure-activity relationships of novel anti-malarial agents. Part 7: N-(3-benzoyl-4-tolylacetylaminophenyl)-3-(5-aryl-2-furyl)acrylic acid amides with polar moieties.

J. Wiesner, H. Jomaa, M. Schlitzer, 2003, Bioorganic & medicinal chemistry letters.

Structure-activity relationships of novel anti-malarial agents: part 5. N-(4-acylamino-3-benzoylphenyl)-[5-(4-nitrophenyl)-2-furyl]acrylic acid amides.

J. Wiesner, H. Jomaa, M. Schlitzer, 2003, Bioorganic & medicinal chemistry letters.

Structure-activity relationships of novel anti-malarial agents. Part 4: N-(3-benzoyl-4-tolylacetylaminophenyl)-3-(5-aryl-2-furyl)acrylic acid amides.

J. Wiesner, H. Jomaa, M. Schlitzer, 2002, Bioorganic & medicinal chemistry letters.

Minireview Microbial isoprenoid biosynthesis and human QN T cell activation

J. Wiesner, H. Jomaa, A. Reichenberg, 2003 .

Delayed parasite elimination in human infections treated with clindamycin parallels 'delayed death' of Plasmodium falciparum in vitro.

J. Wiesner, H. Jomaa, S. Issifou, 2007, International journal for parasitology.

Host cell factor CD59 restricts complement lysis of Plasmodium falciparum‐infected erythrocytes

J. Wiesner, H. Jomaa, P. Kremsner, 1997, European journal of immunology.