H. Jomaa

A. Dilthey, H. Jomaa, K. Pfeffer, 2022, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

Tools for discovery of inhibitors of the 1-deoxy-D-xylulose 5-phosphate (DXP) synthase and DXP reductoisomerase: an approach with enzymes from the pathogenic bacterium Pseudomonas aeruginosa.

J. Wiesner, H. Jomaa, S. Sanderbrand, 2000, FEMS microbiology letters.

Phosphoantigen/IL2 Expansion and Differentiation of Vγ2Vδ2 T Cells Increase Resistance to Tuberculosis in Nonhuman Primates

H. Jomaa, W. Jacobs, N. Letvin, 2013, PLoS pathogens.

Sex‐specific phenotypical and functional differences in peripheral human Vγ9/Vδ2 T cells

H. Jomaa, M. Eberl, F. Dieli, 2006 .

Farnesyltransferase inhibitors inhibit the growth of malaria parasites in vitro and in vivo.

G. Klebe, J. Wiesner, H. Jomaa, 2004, Angewandte Chemie.

Fosmidomycin for the treatment of malaria

J. Wiesner, H. Jomaa, S. Borrmann, 2003, Parasitology Research.

Fosmidomycin Uptake into Plasmodium and Babesia-Infected Erythrocytes Is Facilitated by Parasite-Induced New Permeability Pathways

D. Roos, J. Wiesner, H. Jomaa, 2011, PloS one.

Double Ester Prodrugs of FR900098 Display Enhanced In‐Vitro Antimalarial Activity

J. Wiesner, H. Jomaa, M. Schlitzer, 2007, Archiv der Pharmazie.

Fosmidomycin-clindamycin for Plasmodium falciparum Infections in African children.

J. Wiesner, H. Jomaa, A. Adegnika, 2004, The Journal of infectious diseases.

LytB, a novel gene of the 2‐C‐methyl‐D‐erythritol 4‐phosphate pathway of isoprenoid biosynthesis in Escherichia coli

J. Wiesner, H. Jomaa, B. Altincicek, 2001, FEBS letters.

Functional characterization of GcpE, an essential enzyme of the non‐mevalonate pathway of isoprenoid biosynthesis

J. Wiesner, H. Jomaa, A. Reichenberg, 2002, FEBS letters.

Structure of the (E)‐4‐hydroxy‐3‐methyl‐but‐2‐enyl‐diphosphate reductase from Plasmodium falciparum

J. Wiesner, H. Jomaa, E. Warkentin, 2013, FEBS letters.

Primary MHC-Class II+ Cells Are Necessary To Promote Resting Vδ2 Cell Expansion in Response to (E)-4-Hydroxy-3-Methyl-But-2-Enyl-Pyrophosphate and Isopentenyl Pyrophosphate

H. Jomaa, H. Hackstein, G. Bein, 2012, The Journal of Immunology.

Structure of the GcpE (IspG)–MEcPP complex from Thermus thermophilus

H. Jomaa, U. Ermler, Ingo Rekittke, 2012, FEBS letters.

Possible direct involvement of the active‐site [4Fe–4S] cluster of the GcpE enzyme from Thermus thermophilus in the conversion of MEcPP

J. Wiesner, H. Jomaa, E. Duin, 2007, FEBS letters.

Structure of the GcpE-HMBPP complex from Thermus thermophilius.

H. Jomaa, E. Warkentin, U. Ermler, 2015, Biochemical and biophysical research communications.

Structure of the E‐1‐hydroxy‐2‐methyl‐but‐2‐enyl‐4‐diphosphate synthase (GcpE) from Thermus thermophilus

J. Wiesner, H. Jomaa, E. Warkentin, 2011, FEBS letters.

Synthesis of β- and γ-oxa isosteres of fosmidomycin and FR900098 as antimalarial candidates

J. Wiesner, H. Jomaa, M. Schlitzer, 2008 .

Synthesis of beta- and gamma-oxa isosteres of fosmidomycin and FR900098 as antimalarial candidates.

J. Wiesner, H. Jomaa, M. Schlitzer, 2008, Bioorganic & medicinal chemistry.

Synthesis of α-Substituted Fosmidomycin Analogues as Highly Potent Plasmodium falciparum Growth Inhibitors.

J. Wiesner, H. Jomaa, J. Goeman, 2006 .

Diaryl ester prodrugs of FR900098 with improved in vivo antimalarial activity.

J. Wiesner, H. Jomaa, A. Reichenberg, 2001, Bioorganic & medicinal chemistry letters.

RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA.

J. Wiesner, H. Jomaa, A. Mankin, 2010, Journal of the American Chemical Society.

Studies Addressing the Importance of Charge in the Binding of Fosmidomycin‐Like Molecules to Deoxyxylulosephosphate Reductoisomerase

G. Klebe, J. Wiesner, H. Jomaa, 2008, ChemMedChem.

Fosmidomycin as an Antimalarial Agent

J. Wiesner, H. Jomaa, A. Reichenberg, 2012 .

Plasmodium falciparum: detection of the deoxyxylulose 5-phosphate reductoisomerase activity.

J. Wiesner, H. Jomaa, S. Sanderbrand, 2000, Experimental parasitology.

Crystallographic structures of two bisphosphonate:1-deoxyxylulose-5-phosphate reductoisomerase complexes.

Shunsuke Yajima, Jochen Wiesner, Eric Oldfield, 2004, Journal of the American Chemical Society.

NMR Studies of DOXP Reductoisomerase and its Inhibitor Complex

H. Schwalbe, J. Wiesner, H. Jomaa, 2011, Chembiochem : a European journal of chemical biology.

Occurrence of nonmevalonate and mevalonate pathways for isoprenoid biosynthesis in bacteria of different taxonomic groups

J. Wiesner, H. Jomaa, M. Hintz, 2005, Microbiology.

FR-900098, an antimalarial development candidate that inhibits the non-mevalonate isoprenoid biosynthesis pathway, shows no evidence of acute toxicity and genotoxicity

J. Wiesner, H. Jomaa, A. Reichenberg, 2016, Virulence.

The interplay between classical and alternative isoprenoid biosynthesis controls γδ T cell bioactivity of Listeria monocytogenes

H. Jomaa, M. Hintz, M. Eberl, 2004 .

Sex-specific phenotypical and functional differences in peripheral human Vgamma9/Vdelta2 T cells.

H. Jomaa, M. Eberl, F. Dieli, 2006, Journal of leukocyte biology.

Seeking new targets for antiparasitic agents.

J. Wiesner, H. Jomaa, S. Sanderbrand, 2001, Trends in parasitology.

1-deoxy-D-xylulose-5-phosphate reductoisomerase

G. Klebe, J. Wiesner, H. Jomaa, 2002 .

Interferon-beta therapy reduces CD4+ and CD8+ T-cell reactivity in multiple sclerosis.

H. Jomaa, M. Eberl, P. Oschmann, 2007, Immunology.

Structure-activity relationships of novel anti-malarial agents. Part 7: N-(3-benzoyl-4-tolylacetylaminophenyl)-3-(5-aryl-2-furyl)acrylic acid amides with polar moieties.

J. Wiesner, H. Jomaa, M. Schlitzer, 2003, Bioorganic & medicinal chemistry letters.

Structure-activity relationships of novel anti-malarial agents: part 5. N-(4-acylamino-3-benzoylphenyl)-[5-(4-nitrophenyl)-2-furyl]acrylic acid amides.

J. Wiesner, H. Jomaa, M. Schlitzer, 2003, Bioorganic & medicinal chemistry letters.

Structure-activity relationships of novel anti-malarial agents. Part 4: N-(3-benzoyl-4-tolylacetylaminophenyl)-3-(5-aryl-2-furyl)acrylic acid amides.

J. Wiesner, H. Jomaa, M. Schlitzer, 2002, Bioorganic & medicinal chemistry letters.

Prolonged (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate-driven antimicrobial and cytotoxic responses of pulmonary and systemic Vgamma2Vdelta2 T cells in macaques.

H. Jomaa, A. Reichenberg, M. Hintz, 2007, Journal of immunology.

Minireview Microbial isoprenoid biosynthesis and human QN T cell activation

J. Wiesner, H. Jomaa, A. Reichenberg, 2003 .

Human Vγ9/Vδ2 effector memory T cells express the killer cell lectin‐like receptor G1 (KLRG1)

H. Pircher, H. Jomaa, M. Eberl, 2005 .

Human Vgamma9/Vdelta2 effector memory T cells express the killer cell lectin-like receptor G1 (KLRG1).

H. Pircher, H. Jomaa, M. Eberl, 2005, Journal of leukocyte biology.

Integrated immune responses to infection - cross-talk between human gammadelta T cells and dendritic cells.

H. Jomaa, M. Eberl, A. Hayday, 2004, Immunology.

The interplay between classical and alternative isoprenoid biosynthesis controls gammadelta T cell bioactivity of Listeria monocytogenes.

H. Jomaa, M. Hintz, M. Eberl, 2004, FEBS letters.

Gammadelta T cell immune manipulation during chronic phase of simian-human immunodeficiency virus infection [corrected] confers immunological benefits.

H. Jomaa, A. Reichenberg, M. Hintz, 2009, Journal of immunology.

Mycoplasma penetrans is capable of activating V gamma 9/V delta 2 T cells while other human pathogenic mycoplasmas fail to do so.

H. Jomaa, M. Hintz, M. Eberl, 2004, Infection and immunity.

Delayed parasite elimination in human infections treated with clindamycin parallels 'delayed death' of Plasmodium falciparum in vitro.

J. Wiesner, H. Jomaa, S. Issifou, 2007, International journal for parasitology.

Host cell factor CD59 restricts complement lysis of Plasmodium falciparum‐infected erythrocytes

J. Wiesner, H. Jomaa, P. Kremsner, 1997, European journal of immunology.

A genetic basis for human gammadelta T-cell reactivity towards microbial pathogens.

H. Jomaa, M. Eberl, 2003, Trends in immunology.

γδ T Cell Immune Manipulation during Chronic Phase of Simian HIV Infection Confers Immunological Benefits1

H. Jomaa, A. Reichenberg, M. Hintz, 2009, The Journal of Immunology.

NMR Studies of DOXP Reductoisomerase and its Inhibitor Complex

H. Schwalbe, J. Wiesner, H. Jomaa, 2011, Chembiochem : a European journal of chemical biology.

Paramagnetic intermediates of (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase (GcpE/IspG) under steady-state and pre-steady-state conditions.

J. Wiesner, H. Jomaa, B. Hoffman, 2010, Journal of the American Chemical Society.

Structure of the GcpE-HMBPP complex from Thermus thermophilius.

H. Jomaa, E. Warkentin, U. Ermler, 2015, Biochemical and biophysical research communications.

Novel Deoxyxylulosephosphate‐Reductoisomerase Inhibitors: Fosmidomycin Derivatives with Spacious Acyl Residues

G. Klebe, J. Wiesner, H. Jomaa, 2007, Archiv der Pharmazie.

Left ventricular hemodynamic parameters in the course of acute experimental coxsackievirus B 3 myocarditis.

H. Jomaa, M. Herzum, H. Jomaa, 1995, Journal of molecular and cellular cardiology.

Replacing the pyrophosphate group of HMB-PP by a diphosphonate function abrogates Its potential to activate human gammadelta T cells but does not lead to competitive antagonism.

H. Jomaa, A. Reichenberg, M. Hintz, 2003, Bioorganic & medicinal chemistry letters.