P. Casey

发表

Time-dependent inhibition of isoprenylcysteine carboxyl methyltransferase by indole-based small molecules.

R. Baron, Y. Peterson, J. Otto, 2007, Biochemistry.

A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells.

R. Baron, P. Casey, A. Winter-Vann, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Overview of the Alliance for Cellular Signaling

Temple F. Smith, D. Botstein, A. Arkin, 2002, Nature.

Activation of Rap1 promotes prostate cancer metastasis.

P. Casey, C. Bailey, P. Kelly, 2009, Cancer research.

The GNA13-RhoA signaling axis suppresses expression of tumor protective Kallikreins.

S. A. K. Rasheed, P. Casey, Cui Rong Teo, 2016, Cellular signalling.

Protein prenylation: unique fats make their mark on biology

P. Casey, Mei Wang, 2016, Nature Reviews Molecular Cell Biology.

Enzymology and biology of CaaX protein prenylation.

P. Casey, H. Fu, P J Casey, 1999, Recent progress in hormone research.

Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity.

P. Casey, L. Beese, T. Reid, 2004, Journal of molecular biology.

Post-prenylation-processing enzymes as new targets in oncogenesis

P. Casey, A. Winter-Vann, Ann M. Winter-Vann, 2005, Nature Reviews Cancer.

Site-specific analysis of protein S-acylation by resin-assisted capture[S]

Rainbo Hultman, J. Stamler, P. Casey, 2011, Journal of Lipid Research.

Prenylation of CaaX-type proteins: Basic principles through clinical applications

P. Casey, H. Hurwitz, 2002 .

[2] Isolation of protein prenyltransferases from bovine brain and baculovirus expression system

P. Casey, J. Moomaw, Fang L. Zhang, 1995 .

Rap1 Promotes Multiple Pancreatic Islet Cell Functions and Signals through Mammalian Target of Rapamycin Complex 1 to Enhance Proliferation*

P. Casey, C. Newgard, C. Bailey, 2010, The Journal of Biological Chemistry.

Kinetic studies of protein farnesyltransferase mutants establish active substrate conformation.

P. Casey, C. Fierke, K. Bowers, 2003, Biochemistry.

Lysine164α of protein farnesyltransferase is important for both CaaX substrate binding and catalysis

R. A. Spence, P. Casey, C. Weinbaum, 2001 .

Farnesyltransferase Inhibitors Alter the Prenylation and Growth-stimulating Function of RhoB*

P. Casey, G. Prendergast, P. Lebowitz, 1997, The Journal of Biological Chemistry.

High Affinity for Farnesyltransferase and Alternative Prenylation Contribute Individually to K-Ras4B Resistance to Farnesyltransferase Inhibitors*

P. Casey, A. Cox, J. Fiordalisi, 2003, Journal of Biological Chemistry.

Automated morphometric analysis of stallion spermatozoa.

P. Casey, C. Gravance, R. Davis, 1993, American journal of veterinary research.

Quantification of normal head morphometry of stallion spermatozoa.

P. Casey, J. P. Hughes, C. Gravance, 1996, Journal of reproduction and fertility.

Morphometric differences in sperm head dimensions of fertile and subfertile stallions.

P. Casey, C. Gravance, R. Davis, 1997, Theriogenology.

Sperm head morphometry analysis of ejaculate and dismount stallion semen samples.

P. Casey, C. Gravance, I. Liu, 1997, Animal reproduction science.

Phosphorylation and Nuclear Translocation of a Regulator of G Protein Signaling (RGS10)*

P. Casey, A. Nixon, E. Peralta, 2001, The Journal of Biological Chemistry.

RGSZ1, a Gz-selective Regulator of G Protein Signaling Whose Action Is Sensitive to the Phosphorylation State of Gzα*

P. Casey, A. Miron, T. E. Meigs, 1998, The Journal of Biological Chemistry.

Activation of MAPK/ERK signaling by Burkholderia pseudomallei cycle inhibiting factor (Cif)

P. Casey, Mei Wang, T. Hagen, 2017, PloS one.

Prenylcysteine Lyase Deficiency in Mice Results in the Accumulation of Farnesylcysteine and Geranylgeranylcysteine in Brain and Liver*

S. Griffey, P. Casey, M. Bergo, 2002, The Journal of Biological Chemistry.

Protein Prenyltransferases (*)

P. Casey, M. Seabra, 1996, The Journal of Biological Chemistry.

Prenylation-dependent Association of Ki-Ras with Microtubules

P. Casey, T. Meyer, K. Subramanian, 1997, The Journal of Biological Chemistry.

Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases

P. Casey, S. Pervaiz, A. Kumar, 2013, Cell Death and Disease.

Reciprocal Signaling between the Transcriptional Co-Factor Eya2 and Specific Members of the Gαi Family

P. Casey, M. Linder, J. Glick, 2004, Molecular Pharmacology.

The effects of systemic hypothermia on a murine model of thoracic aortic ischemia reperfusion.

M. Watkins, P. Casey, H. Albadawi, 2010, Journal of vascular surgery.

PJ34, a poly-ADP-ribose polymerase inhibitor, modulates visceral mitochondrial activity and CD14 expression following thoracic aortic ischemia-reperfusion.

M. Watkins, P. Casey, H. Albadawi, 2009, American journal of surgery.

GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer.

P. Casey, M. Bergo, S. Young, 2007, The Journal of clinical investigation.

Pharmacological Targeting of the Mitochondrial Phosphatase PTPMT1

J. Dixon, P. Casey, D. Pagliarini, 2010, Journal of Pharmacology and Experimental Therapeutics.

Mammalian protein geranylgeranyltransferase. Subunit composition and metal requirements.

P. Casey, J. Moomaw, 1992, The Journal of biological chemistry.

High level expression of mammalian protein farnesyltransferase in a baculovirus system. The purified protein contains zinc.

P. Casey, T. Kost, W. J. Chen, 1993, The Journal of biological chemistry.

Functional Interaction between Gαz and Rap1GAP Suggests a Novel Form of Cellular Cross-talk*

P. Casey, J. Meng, P. Polakis, 1999, The Journal of Biological Chemistry.

Activation of Gz Attenuates Rap1-mediated Differentiation of PC12 Cells*

P. Casey, J. Meng, Jingwei Meng, 2002, The Journal of Biological Chemistry.

The COOH-terminal domain of the Rap1A (Krev-1) protein is isoprenylated and supports transformation by an H-Ras:Rap1A chimeric protein

P. Casey, C. Der, F. McCormick, 1991, Molecular and cellular biology.

RGS10 is a selective activator of G alpha i GTPase activity.

T. Hunt, P. Casey, T. Fields, 1996, Nature.

Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release.

P. Casey, T. Fields, D. D. Mckee, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Identification of a Cysteine Residue Essential for Activity of Protein Farnesyltransferase

P. Casey, H. Fu, C. Moomaw, 1996, The Journal of Biological Chemistry.

Prenylation and G protein signaling.

P. Casey, J. Moomaw, J. Thissen, 1994, Recent progress in hormone research.

Biochemistry of protein prenylation.

P. Casey, Patrick J. Casey, 1992, Journal of lipid research.

Chapter 1 – The Enzymology of CAAX Protein Prenylation

P. Casey, K. Hightower, 2011 .

1 Mechanism of catalysis by protein farnesyltransferase

R. A. Spence, P. Casey, 2001 .

cDNA cloning and expression of rat and human protein geranylgeranyltransferase type-I.

B. Giros, P. Casey, R. Diehl, 1994, The Journal of biological chemistry.

Prenylated peptides in identification of specific binding proteins.

M. G. Barrett, P. Casey, J. Thissen, 1995, Methods in enzymology.

Lysine(164)alpha of protein farnesyltransferase is important for both CaaX substrate binding and catalysis.

R. A. Spence, P. Casey, C. Weinbaum, 2001, The Biochemical journal.

Evidence for a Catalytic Role of Zinc in Protein Farnesyltransferase

P. Casey, C. Fierke, Chih‐chin Huang, 1997, The Journal of Biological Chemistry.

A G-protein beta gamma-subunit-responsive phosphoinositide 3-kinase activity in human platelet cytosol.

P. Casey, C. Downes, P. Thomason, 1994, The Journal of biological chemistry.

Microsomal membranes contain a high affinity binding site for prenylated peptides.

P. Casey, J. Thissen, 1993, The Journal of biological chemistry.

Evidence of a role for heterotrimeric GTP-binding proteins in endosome fusion.

P. Casey, M. Colombo, P. Stahl, 1992, Science.

The involvement of growth hormone in equine oocyte maturation, receptor localization and steroid production by cumulus-oocyte complexes in vitro.

P. Casey, S. Bilodeau-Goeseels, J. Kastelic, 2013, Research in veterinary science.

Lipid Modifications of GTP-Binding Regulatory Proteins

P. Casey, 1993 .

(cid:1) -Catenin is a Nek2 substrate involved in centrosome separation

P. Casey, E. Salmon, E. O'Toole, 2007 .

c-Jun Contributes to Transcriptional Control of GNA12 Expression in Prostate Cancer Cells

P. Casey, Udhaya Kumari Udayappan, 2017, Molecules.

Gαz Negatively Regulates Insulin Secretion and Glucose Clearance*

P. Casey, C. Newgard, C. Bailey, 2008, Journal of Biological Chemistry.

A Role for Gz in Pancreatic Islet β-Cell Biology*

P. Casey, T. Fields, A. Nixon, 2005, Journal of Biological Chemistry.

Cyclosporin A--a chemoprotectant against microcystin-LR toxicity.

P. Casey, S. Stohs, S. Hermansky, 1990, Toxicology letters.

Growth hormone (GH) therapy markedly increases the motility of spermatozoa and the concentration of insulin-like growth factor-I in seminal vesicle fluid in the male GH-deficient dwarf rat.

P. Casey, B. Breier, M. Vickers, 1996, Endocrinology.

Rap1 GTPase Inhibits Leukocyte Transmigration by Promoting Endothelial Barrier Function*

P. Casey, L. Quilliam, P. Kelly, 2005, Journal of Biological Chemistry.

Kinetic analysis of zinc ligand mutants of mammalian protein farnesyltransferase.

P. Casey, L. Beese, H. Fu, 1998, Biochemistry.

Protein farnesyltransferase and geranylgeranyltransferase share a common alpha subunit.

P. Casey, Y. Reiss, M. Brown, 1991, Cell.

Analysis of the kinetic mechanism of recombinant human isoprenylcysteine carboxylmethyltransferase (Icmt)

R. Baron, P. Casey, 2004, BMC Biochemistry.

Cocrystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate substrate.

P. Casey, L. Beese, S. Long, 1998, Biochemistry.

RAB4A GTPase regulates epithelial-to-mesenchymal transition by modulating RAC1 activation

P. Casey, Mei Wang, S. Karthikeyan, 2022, Breast Cancer Research.

Therapy with growth hormone: major prospects for the treatment of male subfertility?

P. Casey, B. Breier, M. Vickers, 1998, Endocrine journal.

Therapy with Growth Hormone : Major Prospects for the pY wit Treatment of Male Subfertility ?

P. Casey, B. Breier, M. Vickers, 2022 .

Expression of cDNAs for G proteins in Escherichia coli. Two forms of Gs alpha stimulate adenylate cyclase.

P. Casey, A. Gilman, M. Graziano, 1987, The Journal of biological chemistry.

Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors.

J. B. Higgins, M. Caron, P. Casey, 1992, Science.

[8] Assays for G protein βγ subunit activity

P. Casey, Joyce B. Higgins, 1996 .

p21ras is modified by a farnesyl isoprenoid.

P. Casey, C. Der, J. Buss, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Lysosomal Prenylcysteine Lyase Is a FAD-dependent Thioether Oxidase*

P. Casey, W. Tschantz, R. Coates, 2001, The Journal of Biological Chemistry.

Distinct Regions of the Cadherin Cytoplasmic Domain Are Essential for Functional Interaction with Gα12 and β-Catenin*

P. Casey, D. D. Kaplan, T. Meigs, 2001, The Journal of Biological Chemistry.

Properties and kinetic mechanism of recombinant mammalian protein geranylgeranyltransferase type I.

P. Casey, J. Moomaw, F. L. Zhang, 1994, The Journal of biological chemistry.

Blood plasma concentrations of insulin-like growth factor-I (IGF-I) in resting standardbred horses.

P. Casey, T. Tobin, Z. Champion, 2002, Veterinary journal.

Distinct regions of the cadherin cytoplasmic domain are essential for functional interaction with Galpha 12 and beta-catenin.

P. Casey, D. D. Kaplan, T. Meigs, 2001, The Journal of biological chemistry.

Isolation of protein prenyltransferases from bovine brain and baculovirus expression system.

P. Casey, J. Moomaw, F. L. Zhang, 1995, Methods in enzymology.

The Regulator of G Protein Signaling Domain of Axin Selectively Interacts with Gα12 but Not Gα13

P. Casey, T. Fields, Laura N. Stemmle, 2006, Molecular Pharmacology.

Interaction of Gα12 and Gα13 with the cytoplasmic domain of cadherin provides a mechanism for β-catenin release

P. Casey, T. Fields, D. D. Mckee, 2001 .

Protein prenylation: molecular mechanisms and functional consequences.

P. Casey, P J Casey, F L Zhang, 1996, Annual review of biochemistry.

Stereospecificity and Kinetic Mechanism of Human Prenylcysteine Lyase, an Unusual Thioether Oxidase* 210

P. Casey, R. Coates, H. Pyun, 2002, The Journal of Biological Chemistry.

Substrate Binding Is Required for Release of Product from Mammalian Protein Farnesyltransferase*

P. Casey, E. Furfine, P J Casey, 1997, The Journal of Biological Chemistry.

Characterization of Prenylcysteines That Interact with P-glycoprotein and Inhibit Drug Transport in Tumor Cells (*)

P. Casey, R. Fine, Lili Zhang, 1995, The Journal of Biological Chemistry.

A Novel Protein Geranylgeranyltransferase-I Inhibitor with High Potency, Selectivity, and Cellular Activity*

Yuri K Peterson, Y. Peterson, P. Casey, 2006, Journal of Biological Chemistry.

H-Ras peptide and protein substrates bind protein farnesyltransferase as an ionized thiolate.

P. Casey, C. Fierke, C. Huang, 1998, Biochemistry.

Crystal Structure of Protein Farnesyltransferase at 2.25 Angstrom Resolution

P. Casey, L. Beese, Hee-won Park, 1997, Science.

Reaction path of protein farnesyltransferase at atomic resolution

Stephen B. Long, P. Casey, L. Beese, 2002, Nature.

The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures.

P. Casey, L. Beese, S. Long, 2000, Structure.

The Biochemistry of Farnesyltransferase and Geranylgeranyltransferase I 2

P. Casey, C. Fierke, Chih‐chin Huang, 2019 .

Structure of mammalian protein geranylgeranyltransferase type‐I

P. Casey, L. Beese, T. Reid, 2003, The EMBO journal.

Protein farnesyltransferase exhibits pH-dependent activity towards H-Ras peptide substrates

P. Casey, C. Fierke, K. Hightower, 2002 .

The Biochemistry of Farnesyltransferase and Geranylgeranyltransferase I

P. Casey, C. Fierke, Chih‐chin Huang, 2001 .

Protein farnesyltransferase, beta subunit

P. Casey, 2004 .

IGF-I treatment increases motility and improves morphology of immature spermatozoa in the GH-deficient dwarf (dw/dw) rat.

P. Casey, M. Vickers, C. Gravance, 1999, Growth Hormone & IGF Research.

Column separation of motile sperm from stallion semen.

P. Casey, E. Drobnis, I. Liu, 1993, Journal of andrology.

Growth hormone or insulin-like growth factor-I extends longevity of equine spermatozoa in vitro.

P. Casey, M. Vickers, C. Gravance, 2002, Theriogenology.

Impaired sperm characteristics in postpubertal growth-hormone-deficient dwarf (dw/dw) rats.

P. Casey, B. Breier, M. Vickers, 1997, Animal reproduction science.

Validation of an acrosomal stain for equine sperm that differentiates between living and dead sperm.

A. I. Yudin, P. Casey, E. Drobnis, 1993, Journal of Andrology.

Effects of cryopreservation on bull sperm head morphometry.

P. Casey, R. Vishwanath, D. Garner, 1998, Journal of andrology.

Control of RhoA Methylation by Carboxylesterase I*

P. Casey, P. Potter, I. Cushman, 2013, The Journal of Biological Chemistry.

G protein involvement in receptor-effector coupling.

P. Casey, A. Gilman, A G Gilman, 1988, The Journal of biological chemistry.

Targeting Ras signaling through inhibition of carboxyl methylation: An unexpected property of methotrexate

P. Casey, A. Winter-Vann, M. Bergo, 2003, Proceedings of the National Academy of Sciences of the United States of America.

G proteins control diverse pathways of transmembrane signaling 1

P. Casey, A. Gilman, M. Freissmuth, 1989, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Inhibition of adenylosuccinate lyase by L-alanosyl-5-aminoimidazole-4-carboxylic acid ribonucleotide (alanosyl-AICOR).

P. Casey, J. Lowenstein, 1987, Biochemical pharmacology.

Subtype-specific binding of azidoanilido-GTP by purified G protein alpha subunits.

P. Casey, T. Fields, M. Linder, 1994, Biochemistry.

Protein lipidation in cell signaling.

P. Casey, Patrick J. Casey, 1995, Science.

In vitro processing of recombinant G protein gamma subunits. Requirements for assembly of an active beta gamma complex.

J. B. Higgins, P. Casey, Joyce B. Higgins, 1994, The Journal of biological chemistry.

Percentage of normal sperm heads is significantly increased by Percoll separation of semen.

P. Casey, C. Gravance, Z. Champion, 2002, International journal of andrology.

Computer-assisted sperm head morphometry analysis (ASMA) of cryopreserved ram spermatozoa.

P. Casey, C. Gravance, Z. Champion, 1998, Theriogenology.

Computer automated morphometric analysis of bull sperm heads.

P. Casey, R. Vishwanath, C. Pitt, 1996, Theriogenology.

Computer automated sperm head morphometry analysis (ASMA) of goat spermatozoa.

P. Casey, K. M. Lewis, C. Gravance, 1995, Theriogenology.

EFFECTS OF PITUITARY HORMONES AND NADPH ON ACETATE UTILIZATION IN OVARIAN AND ADRENOCORTICAL TISSUES.

P. Casey, K. Savard, 1964, Endocrinology.

Isoprenylcysteine carboxylmethyltransferase function is essential for RAB4A-mediated integrin β3 recycling, cell migration and cancer metastasis

P. Casey, M. Wang, M. Do, 2017, Oncogene.

Topology of Mammalian Isoprenylcysteine Carboxyl Methyltransferase Determined in Live Cells with a Fluorescent Probe

P. Casey, M. Philips, Ian M Ahearn, 2009, Molecular and Cellular Biology.

Genetic and pharmacologic analyses of the role of Icmt in Ras membrane association and function.

P. Casey, M. Bergo, S. Young, 2006, Methods in enzymology.

Isoprenylcysteine Carboxyl Methyltransferase Deficiency in Mice*

J. Otto, P. Casey, M. Bergo, 2001, The Journal of Biological Chemistry.

Arachidonate and Related Unsaturated Fatty Acids Selectively Inactivate the Guanine Nucleotide-binding Regulatory Protein, G(*)

P. Casey, J. Glick, G. Santoyo, 1996, The Journal of Biological Chemistry.

A Prenylated p47phox-p67phox-Rac1 Chimera Is a Quintessential NADPH Oxidase Activator

P. Casey, Y. Berdichevsky, E. Pick, 2010, The Journal of Biological Chemistry.

Enzymatic modification of proteins with a geranylgeranyl isoprenoid.

P. Casey, J. Moomaw, J. Thissen, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Inhibitory G proteins and their receptors: emerging therapeutic targets for obesity and diabetes

P. Casey, A. Linnemann, M. Kimple, 2014, Experimental & Molecular Medicine.

Analysis of the molecular interaction of the farnesyl moiety of transducin through the use of a photoreactive farnesyl analogue.

Y. Fukada, Y. Ohya, P. Casey, 2004, Biochemistry.

ROLE OF VITAMIN A IN GAMMA GLOBULIN BIOSYNTHESIS AND URIC ACID METABOLISM OF MONGOLOIDS.

M. D. Appleton, P. Casey, F. Castellino, 1964, American journal of mental deficiency.

Isoprenylcysteine carboxylmethyltransferase is required for the impact of mutant KRAS on TAZ protein level and cancer cell self-renewal

P. Casey, Mei Wang, K. A. Manu, 2020, Oncogene.

Influence of metal ions on substrate binding and catalytic activity of mammalian protein geranylgeranyltransferase type-I.

P. Casey, Fang L. Zhang, F. L. Zhang, 1996, The Biochemical journal.

G-Protein Subunit Lipidation in Membrane Association and Signaling

P. Casey, J. Thissen, 1993 .

GNA13 loss in germinal center B cells leads to impaired apoptosis and promotes lymphoma in vivo.

I. Lossos, S. Dave, S. A. K. Rasheed, 2016, Blood.

Role of G12 proteins in oncogenesis and metastasis

P. Casey, J. Juneja, Juhi Juneja, 2009, British journal of pharmacology.

The emerging roles of Gα12/13 proteins on the hallmarks of cancer in solid tumors

S. A. K. Rasheed, P. Casey, Mei Wang, 2021, Oncogene.

Isoprenylcysteine carboxylmethyltransferase is critical for malignant transformation and tumor maintenance by all RAS isoforms

P. Casey, Mei Wang, J. Tang, 2017, Oncogene.

Amino derivatives of indole as potent inhibitors of isoprenylcysteine carboxyl methyltransferase.

P. Casey, Mei Wang, A. Schüller, 2010, Journal of medicinal chemistry.

A Small Molecule Inhibitor of Isoprenylcysteine Carboxymethyltransferase Induces Autophagic Cell Death in PC3 Prostate Cancer Cells*♦

P. Casey, Mei Wang, J. Leow, 2008, Journal of Biological Chemistry.

Inhibition of purified p21 ras farnesyl:protein transferase by Cys-AAX tetrapeptides

P. Casey, Y. Reiss, J. Goldstein, 1990, Cell.

A Role for the G12 Family of Heterotrimeric G Proteins in Prostate Cancer Invasion*

P. Casey, J. Madden, T. Fields, 2006, Journal of Biological Chemistry.

The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis.

M. Dewhirst, P. Casey, C. Der, 2006, Proceedings of the National Academy of Sciences of the United States of America.

beta-Catenin is a Nek2 substrate involved in centrosome separation.

P. Casey, E. Salmon, E. O'Toole, 2008, Genes & development.

Cloning, Expression, and Cellular Localization of a Human Prenylcysteine Lyase*

P. Casey, Lili Zhang, W. Tschantz, 1999, The Journal of Biological Chemistry.

Isolation and Characterization of a Prenylcysteine Lyase from Bovine Brain*

P. Casey, Lili Zhang, W. Tschantz, 1997, The Journal of Biological Chemistry.

p21cip1/waf1 Coordinates Autophagy, Proliferation and Apoptosis in Response to Metabolic Stress

P. Casey, Mei Wang, K. A. Manu, 2019, Cancers.

Gα-13 induces CXC motif chemokine ligand 5 expression in prostate cancer cells by transactivating NF-κB

S. A. K. Rasheed, P. Casey, Debleena Ray, 2019, The Journal of Biological Chemistry.

Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development.

M. Barbacid, P. Casey, P. Dubus, 2005, Cancer cell.

A Role for Rac3 GTPase in the Regulation of Autophagy*

P. Casey, W. Zhu, Honglian Tong, 2011, The Journal of Biological Chemistry.

Rho GTPase activity modulates Wnt3a/beta-catenin signaling.

P. Casey, S. McCall, T. Fields, 2009, Cellular signalling.

Androgen Receptor Activation by Gs Signaling in Prostate Cancer Cells*

P. Casey, Y. Daaka, P. Kelly, 2005, Journal of Biological Chemistry.

Absence of the CAAX Endoprotease Rce1: Effects on Cell Growth and Transformation

A. Balmain, J. Otto, P. Casey, 2002, Molecular and Cellular Biology.

Signalling functions and biochemical properties of pertussis toxin-resistant G-proteins.

P. Casey, T. Fields, P J Casey, 1997, The Biochemical journal.

Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf.

P. Casey, M. Bergo, S. Young, 2004, The Journal of clinical investigation.

MicroRNA-31 controls G protein alpha-13 (GNA13) expression and cell invasion in breast cancer cells

S. A. K. Rasheed, Wei Zhou, P. Casey, 2015, Molecular Cancer.

Bovine Colostrum Supplementation Does Not Influence Serum Insulin-like Growth Factor-1 in Horses in Race Training

P. Casey, D. Haines, T. Tobin, 2014 .

The effects of bovine recombinant growth hormone administration on insulin-like growth factor-I and the haemopoietic system in thoroughbred geldings.

P. Casey, M. Vickers, Z. Champion, 2000, Veterinary journal.

Inhibition of Isoprenylcysteine Carboxylmethyltransferase Induces Cell-Cycle Arrest and Apoptosis through p21 and p21-Regulated BNIP3 Induction in Pancreatic Cancer

P. Casey, W. Zhu, J. T. Teh, 2017, Molecular Cancer Therapeutics.

Replicate and technician variation associated with computer aided bull sperm head morphometry analysis (ASMA).

R Vishwanath, P. Casey, R. Vishwanath, 1999, International journal of andrology.

The effects of cryopreservation on the morphometric dimensions of caprine sperm heads.

P. Casey, C. Gravance, Z. Champion, 1997, Animal reproduction science.

Pre-freeze bull sperm head morphometry related to post-thaw fertility.

P. Casey, M. Casey, C. Gravance, 2009, Animal reproduction science.

Prenylated C17orf37 Induces Filopodia Formation to Promote Cell Migration and Metastasis*

P. Casey, J. Vishwanatha, I. Cushman, 2011, The Journal of Biological Chemistry.

Poly adenosine diphosphate-ribose polymerase inhibitor PJ34 abolishes systemic proinflammatory responses to thoracic aortic ischemia and reperfusion.

M. Watkins, P. Casey, J. Black, 2006, Journal of the American College of Surgeons.

Deletion of GαZ Protein Protects against Diet-induced Glucose Intolerance via Expansion of β-Cell Mass*

P. Casey, C. Newgard, J. B. Moss, 2012, The Journal of Biological Chemistry.

Evaluating the Epithelial-Mesenchymal Program in Human Breast Epithelial Cells Cultured in Soft Agar Using a Novel Macromolecule Extraction Protocol

P. Casey, Mei Wang, H. Lau, 2021, Cancers.

The C-terminal Polylysine Region and Methylation of K-Ras Are Critical for the Interaction between K-Ras and Microtubules*

J. Otto, P. Casey, M. Bergo, 2000, The Journal of Biological Chemistry.

RGS10 is a selective activator of Gαi GTPase activity

T. Hunt, P. Casey, T. Fields, 1996, Nature.

Galpha12 and Galpha13 negatively regulate the adhesive functions of cadherin.

P. Casey, M. Fedor-Chaiken, R. Brackenbury, 2002, The Journal of biological chemistry.

Pertussis-toxin-sensitive Gα subunits selectively bind to C-terminal domain of neuronal GIRK channels: evidence for a heterotrimeric G-protein-channel complex

P. Casey, P. Slesinger, C. Arrabit, 2005, Molecular and Cellular Neuroscience.

Evidence that direct binding of Gβγ to the GIRK1 G protein-gated inwardly rectifying K+ channel is important for channel activation

Y. Jan, L. Jan, P. Casey, 1995, Neuron.

Evidence that direct binding of G beta gamma to the GIRK1 G protein-gated inwardly rectifying K+ channel is important for channel activation.

Y. Jan, L. Jan, P. Casey, 1995, Neuron.

Analysis of the regulation of microtubule dynamics by interaction of RGSZ1 (RGS20) with the neuronal stathmin, SCG10.

P. Casey, A. Nixon, 2004, Methods in enzymology.

G protein gamma subunits contain a 20-carbon isoprenoid.

P. Casey, A. Gilman, P. Sternweis, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Can prenylcysteines be exploited as ligands for mammalian multidrug-resistance transporters?

P. Casey, L. Hurwitz, 1997, Chemistry & biology.

Lipid modifications of G proteins.

P. Casey, P J Casey, Patrick J. Casey, 1994, Current opinion in cell biology.

Protein farnesyltransferase and geranylgeranyltransferase share a common α subunit

P. Casey, Y. Reiss, J. Goldstein, 1991, Cell.

Interacting Targets of the Farnesyl of Transducin γ-Subunit

Y. Fukada, P. Casey, M. Umeda, 2008, Biochemistry.

Targeted Inactivation of the Isoprenylcysteine Carboxyl Methyltransferase Gene Causes Mislocalization of K-Ras in Mammalian Cells*

J. Otto, P. Casey, M. Bergo, 2000, The Journal of Biological Chemistry.

Disruption of the Mouse Rce1 Gene Results in Defective Ras Processing and Mislocalization of Ras within Cells*

J. Otto, P. Casey, S. Young, 1999, The Journal of Biological Chemistry.

Rac1, a low-molecular-mass GTP-binding-protein with high intrinsic GTPase activity and distinct biochemical properties.

P. Casey, R. Snyderman, E. Tomhave, 1992, European journal of biochemistry.

Farnesylation of YDJ1p is required for function at elevated growth temperatures in Saccharomyces cerevisiae.

P. Casey, A. Caplan, M. Douglas, 1992, The Journal of biological chemistry.

Biologic functions of the G12 subfamily of heterotrimeric g proteins: growth, migration, and metastasis.

P. Casey, P. Kelly, Patrick Kelly, 2007, Biochemistry.

Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells.

Jesse R. Dixon, C. Worby, P. Casey, 2005, Molecular cell.

The effect of combined arterial hemodynamics on saphenous venous endothelial nitric oxide production.

P. Casey, W. Abbott, G. Dai, 2001, Journal of vascular surgery.

Biochemical and morphological correlation of oxidant-induced pulmonary injury: low dose exposure to paraquat, oxygen, and ozone.

M. Cosio, D. Niewoehner, P. Casey, 1979, Archives of environmental health.

Respiratory Capacity and Reserve Predict Cell Sensitivity to Mitochondria Inhibitors: Mechanism-Based Markers to Identify Metformin-Responsive Cancers

P. Casey, C. Newgard, W. Zhu, 2019, Molecular Cancer Therapeutics.

Gz, a guanine nucleotide-binding protein with unique biochemical properties.

M. Simon, P. Casey, A. Gilman, 1990, The Journal of biological chemistry.

Suppression of isoprenylcysteine carboxylmethyltransferase compromises DNA damage repair

P. Casey, Mei Wang, Jingyi Tang, 2021, Life science alliance.

G12 Signaling through c-Jun NH2-Terminal Kinase Promotes Breast Cancer Cell Invasion

P. Casey, J. Juneja, I. Cushman, 2011, PloS one.

Assay of G-protein beta gamma-subunit complex by catalytic support of ADP-ribosylation of Go alpha.

P. Casey, A. Gilman, I. Pang, 1991, Methods in enzymology.

Role of G proteins in transmembrane signaling.

P. Casey, A. Gilman, M. Freissmuth, 1988, Cold Spring Harbor symposia on quantitative biology.

An improved isoprenylcysteine carboxylmethyltransferase inhibitor induces cancer cell death and attenuates tumor growth in vivo

P. Casey, Mei Wang, Tianming Yang, 2014, Cancer biology & therapy.

Myristoylated alpha subunits of guanine nucleotide-binding regulatory proteins.

P. Casey, A. Gilman, S. Mumby, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Gα12 and Gα13 Negatively Regulate the Adhesive Functions of Cadherin*

P. Casey, M. Fedor-Chaiken, R. Brackenbury, 2002, The Journal of Biological Chemistry.

Effects of pharmacologic inhibition of protein geranylgeranyltransferase type I on aqueous humor outflow through the trabecular meshwork.

Y. Peterson, P. Casey, P. Rao, 2008, Investigative ophthalmology & visual science.

A Role for Gαz in regulating seizure susceptibility

K. Dzirasa, P. Casey, Rainbo Hultman, 2019, bioRxiv.

Signaling Through Gz

P. Casey, Rainbo Hultman, M. Kimple, 2009 .

Chapter 219 - Signaling Through G z

P. Casey, Jingwei Meng, 2003 .

Phosphorylation of Gzα by Protein Kinase C Blocks Interaction with the βγ Complex (*)

P. Casey, T. Fields, 1995, The Journal of Biological Chemistry.

Cloning and Characterization of a Mammalian Prenyl Protein-specific Protease*

J. Otto, P. Casey, S. Young, 1999, The Journal of Biological Chemistry.

G protein beta gamma subunits from bovine brain and retina: equivalent catalytic support of ADP-ribosylation of alpha subunits by pertussis toxin but differential interactions with Gs alpha.

P. Casey, A. Gilman, M. Graziano, 1989, Biochemistry.

The role of prenylation in G-protein assembly and function.

J. B. Higgins, J B Higgins, P. Casey, 1996, Cellular signalling.

The effect of growth hormone (GH) and insulin-like growth factor-I (IGF-I) on in vitro maturation of equine oocytes

P. Casey, S. Bilodeau-Goeseels, J. Kastelic, 2011, Zygote.

Identification of a Role for β-Catenin in the Establishment of a Bipolar Mitotic Spindle*

P. Casey, P. Kelly, D. D. Kaplan, 2004, Journal of Biological Chemistry.

Protein farnesyltransferase: kinetics of farnesyl pyrophosphate binding and product release.

P. Casey, E. Furfine, J. Leban, 1995, Biochemistry.

Purification of adenylosuccinate lyase from rat skeletal muscle by a novel affinity column. Stabilization of the enzyme, and effects of anions and fluoro analogues of the substrate.

P. Casey, J. Lowenstein, 1987, The Biochemical journal.

Conversion of protein farnesyltransferase to a geranylgeranyltransferase.

P. Casey, L. Beese, K. L. Terry, 2006, Biochemistry.

GNA13 expression promotes drug resistance and tumor-initiating phenotypes in squamous cell cancers

S. A. K. Rasheed, F. Chong, P. Casey, 2017, Oncogene.

MicroRNA-182 and MicroRNA-200a Control G-protein Subunit α-13 (GNA13) Expression and Cell Invasion Synergistically in Prostate Cancer Cells

S. A. K. Rasheed, P. Casey, P. M. Voorhoeve, 2013, The Journal of Biological Chemistry.

Selective Uncoupling of Gα12 from Rho-mediated Signaling*

P. Casey, J. Juneja, D. D. Kaplan, 2005, Journal of Biological Chemistry.

Testicular and spermatozoan parameters in the pukeko (Porphyrio porphyrio melanotus).

P. Casey, M. Casey, P. Teal, 2008, Animal reproduction science.

Role of Isoprenylcysteine Carboxylmethyltransferase-catalyzed Methylation in Rho Function and Migration*

P. Casey, I. Cushman, 2009, The Journal of Biological Chemistry.

Breast cancer cell invasion mediated by Gα12 signaling involves expression of interleukins-6 and −8, and matrix metalloproteinase-2

P. Casey, Udhaya Kumari, Crystal Y. Chia, 2014, Journal of molecular signaling.

Review of the Current Status of Thresholds/Withdrawal Time Guidelines for Therapeutic Medications in Performance Horses

P. Casey, W. Karpiesiuk, C. Hughes, 2008 .

On the Physiological Importance of Endoproteolysis of CAAX Proteins

J. Otto, P. Casey, M. Bergo, 2004, Journal of Biological Chemistry.

Gαz regulates BDNF-induction of axon growth in cortical neurons

P. Casey, Rainbo Hultman, Nadine Michel, 2014, Molecular and Cellular Neuroscience.

Phosphorylation of Gz in human platelets. Selectivity and site of modification.

P. Casey, L. Brass, D. Manning, 1991, The Journal of biological chemistry.

Structural characterization of prenyl groups attached to proteins

M. Gelb, P. Casey, W. Howald, 1990 .

RHO methylation matters

P. Casey, I. Cushman, 2011, Cell adhesion & migration.

Enhanced Bovine Colostrum Supplementation Shortens the Duration of Respiratory Disease in Thoroughbred Yearlings

P. Casey, D. Haines, T. Tobin, 2016 .

Discovery of geranylgeranyltransferase-I inhibitors with novel scaffolds by the means of quantitative structure-activity relationship modeling, virtual screening, and experimental validation.

Alexander Tropsha, Yuri K Peterson, A. Tropsha, 2009, Journal of medicinal chemistry.

Poly(adenosine diphosphate ribose) polymerase inhibition modulates spinal cord dysfunction after thoracoabdominal aortic ischemia-reperfusion.

M. Frosch, M. Watkins, P. Casey, 2005, Journal of vascular surgery.

MicroRNA-31 controls G protein alpha-13 (GNA13) expression and cell invasion in breast cancer cells

S. A. K. Rasheed, P. Casey, W. Zhou, 2015, Molecular Cancer.

RHO GTPASE ACTIVITY MODULATES WNT3A/ β -CATENIN SIGNALING

P. Casey, S. McCall, T. Fields, 2009 .

Non-peptidic, non-prenylic inhibitors of the prenyl protein-specific protease Rce1.

P. Casey, A. Winter-Vann, M. Schlitzer, 2001, Bioorganic & medicinal chemistry letters.

The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis.

M. Dewhirst, P. Casey, C. Der, 2006, Proceedings of the National Academy of Sciences of the United States of America.

The Hepatitis Delta Virus Large Antigen Is Farnesylated Both in Vitro and in Animal Cells (*)

P. Casey, J. Otto, 1996, The Journal of Biological Chemistry.

Bovine colostrum supplementation optimises earnings, performance and recovery in racing Thoroughbreds

P. Casey, D. Haines, T. Tobin, 2014 .

Substitution of cadmium for zinc in farnesyl:protein transferase alters its substrate specificity.

W. R. Bishop, P. Casey, H. Fu, 1996, Biochemistry.

Inhibition of isoprenylcysteine carboxylmethyltransferase augments BCR-ABL1 tyrosine kinase inhibition-induced apoptosis in chronic myeloid leukemia.

B. Ng, P. Casey, C. Chuah, 2016, Experimental hematology.

Farnesylation of nonpeptidic thiol compounds by protein farnesyltransferase.

P. Casey, C. Fierke, K. Hightower, 2001, Biochemistry.

Functionalized indoleamines as potent, drug-like inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt).

Mei Wang, P. Casey, S. Yap, 2013, European journal of medicinal chemistry.

Quantitative structure-activity relationship (QSAR) of indoloacetamides as inhibitors of human isoprenylcysteine carboxyl methyltransferase.

R. Baron, P. Casey, J. Leow, 2007, Bioorganic & medicinal chemistry letters.

Expression of Mammalian Protein Farnesyltransferase in a Baculovirus System

P. Casey, J. Moomaw, 1994 .

Chemical Analysis of Fatty Acids Covalently Attached to Proteins

P. Casey, J. Buss, 1988 .

The regulator of G protein signaling domain of axin selectively interacts with Galpha12 but not Galpha13.

P. Casey, T. Fields, Laura N. Stemmle, 2006, Molecular pharmacology.

A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells.

R. Baron, P. Casey, A. Winter-Vann, 2005, Proceedings of the National Academy of Sciences of the United States of America.

GNA13 loss in germinal center B cells leads to impaired apoptosis and promotes lymphoma in vivo.

I. Lossos, S. Dave, S. A. K. Rasheed, 2016, Blood.

Pertussis-toxin-sensitive Galpha subunits selectively bind to C-terminal domain of neuronal GIRK channels: evidence for a heterotrimeric G-protein-channel complex.

P. Casey, P. Slesinger, C. Arrabit, 2005, Molecular and cellular neurosciences.

Deletion of GαZ Protein Protects against Diet-induced Glucose Intolerance via Expansion of β-Cell Mass*

P. Casey, C. Newgard, J. B. Moss, 2012, The Journal of Biological Chemistry.

A Small Molecule Inhibitor of Isoprenylcysteine Carboxymethyltransferase Induces Autophagic Cell Death in PC3 Prostate Cancer Cells*♦

P. Casey, Mei Wang, J. Leow, 2008, Journal of Biological Chemistry.

A Prenylated p47phox-p67phox-Rac1 Chimera Is a Quintessential NADPH Oxidase Activator

P. Casey, Y. Berdichevsky, E. Pick, 2010, The Journal of Biological Chemistry.

An improved isoprenylcysteine carboxylmethyltransferase inhibitor induces cancer cell death and attenuates tumor growth in vivo

P. Casey, Mei Wang, Tianming Yang, 2014, Cancer biology & therapy.

The effect of growth hormone (GH) and insulin-like growth factor-I (IGF-I) on in vitro maturation of equine oocytes

P. Casey, J. Kastelic, B. Ball, 2011, Zygote.

Amino derivatives of indole as potent inhibitors of isoprenylcysteine carboxyl methyltransferase.

P. Casey, Mei Wang, A. Schüller, 2010, Journal of medicinal chemistry.

The Interaction of RGSZ1 with SCG10 Attenuates the Ability of SCG10 to Promote Microtubule Disassembly*

P. Casey, A. Nixon, G. Grenningloh, 2002, The Journal of Biological Chemistry.

A high-performance liquid chromatography method for the quantification of cysmethynil, an inhibitor of isoprenylcysteine carboxylmethyl transferase, in mouse plasma.

P. Casey, Mei Wang, How-sung Lee, 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.