C. Rock

发表

Enoyl-Acyl Carrier Protein Reductase (fabI) Plays a Determinant Role in Completing Cycles of Fatty Acid Elongation in Escherichia coli(*)

R. Heath, C. Rock, 1995, The Journal of Biological Chemistry.

Atg8 transfer from Atg7 to Atg3: a distinctive E1-E2 architecture and mechanism in the autophagy pathway.

Michal Hammel, D. Green, C. Rock, 2011, Molecular cell.

RhlA Converts β-Hydroxyacyl-Acyl Carrier Protein Intermediates in Fatty Acid Synthesis to the β-Hydroxydecanoyl-β-Hydroxydecanoate Component of Rhamnolipids in Pseudomonas aeruginosa

C. Rock, Kun Zhu, 2008, Journal of bacteriology.

Regulation of fatty acid biosynthesis in Escherichia coli.

C. Rock, J. Cronan, S. Jackowski, 1993, Microbiological reviews.

Prediction of Mechanisms of Action of Antibacterial Compounds by Gene Expression Profiling

C. Rock, H. Loferer, C. Schaab, 2004, Antimicrobial Agents and Chemotherapy.

Microbiology: A triclosan-resistant bacterial enzyme

Charles O. Rock, Richard J. Heath, R. Heath, 2000, Nature.

Cloning of a Novel Phosphoprotein Regulated by Colony-stimulating Factor 1 Shares a Domain with the Drosophiladisabled Gene Product (*)

C. Rock, Xiang-Xi Xu, S. Jackowski, 1995, The Journal of Biological Chemistry.

Transformation by the v‐fms oncogene product: An analog of the CSF‐1 receptor

M. Roussel, C. Rock, C. Sherr, 1987, Journal of cellular biochemistry.

Fatty acid metabolism in sn-glycerol-3-phosphate acyltransferase (plsB) mutants

C. Rock, S. Jackowski, C. L. Cooper, 1987, Journal of bacteriology.

Altered molecular form of acyl carrier protein associated with beta-ketoacyl-acyl carrier protein synthase II (fabF) mutants

C. Rock, S. Jackowski, 1987, Journal of bacteriology.

Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.

C. Rock, S. Jackowski, L. Hsu, 1991, The Journal of biological chemistry.

Overproduction of beta-ketoacyl-acyl carrier protein synthase I imparts thiolactomycin resistance to Escherichia coli K-12

C. Rock, S. Jackowski, J. Tsay, 1992, Journal of bacteriology.

Isolation and characterization of the beta-ketoacyl-acyl carrier protein synthase III gene (fabH) from Escherichia coli K-12.

C. Rock, T. Larson, S. Jackowski, 1992, The Journal of biological chemistry.

The dedB (usg) open reading frame of Escherichia coli encodes a subunit of acetyl-coenzyme A carboxylase

C. Rock, J. Cronan, S. J. Li, 1992, Journal of bacteriology.

Thiolactomycin resistance in Escherichia coli is associated with the multidrug resistance efflux pump encoded by emrAB

C. Rock, S. Jackowski, J. Tsay, 1993, Journal of bacteriology.

Regulation of fatty acid biosynthesis in Escherichia coli

C. Rock, J. Cronan, S. Jackowski, 1993 .

A Pseudomonas aeruginosa transcription factor that senses fatty acid structure

C. Rock, Yong-mei Zhang, Kun Zhu, 2007, Molecular microbiology.

Structural Basis for the Transcriptional Regulation of Membrane Lipid Homeostasis

C. Rock, C. Subramanian, Yong-mei Zhang, 2010, Nature Structural &Molecular Biology.

Regulation of cytosolic phospholipase A2 phosphorylation and eicosanoid production by colony-stimulating factor 1.

C. Leslie, C. Rock, S. Jackowski, 1994, The Journal of biological chemistry.

Host Fatty Acid Utilization by Staphylococcus aureus at the Infection Site

C. Rock, C. Subramanian, J. Rosch, 2020, mBio.

A fatty acid-binding protein of Streptococcus pneumoniae facilitates the acquisition of host polyunsaturated fatty acids

C. Rock, S. White, J. Gullett, 2019, The Journal of Biological Chemistry.

Identification of a two-component fatty acid kinase responsible for host fatty acid incorporation by Staphylococcus aureus

C. Rock, C. Subramanian, J. Rosch, 2014, Proceedings of the National Academy of Sciences.

Auxotrophs Do Not Proliferate in Mice Staphylococcus aureus Fatty Acid

C. Rock, J. Rosch, Joshua B Parsons, 2014 .

FabH Mutations Confer Resistance to FabF-Directed Antibiotics in Staphylococcus aureus

C. Rock, Joshua B Parsons, Matthew W. Frank, 2014, Antimicrobial Agents and Chemotherapy.

Staphylococcus aureus Fatty Acid Auxotrophs Do Not Proliferate in Mice

C. Rock, J. Rosch, Joshua B Parsons, 2013, Antimicrobial Agents and Chemotherapy.

Perturbation of Staphylococcus aureus Gene Expression by the Enoyl-Acyl Carrier Protein Reductase Inhibitor AFN-1252

C. Rock, N. Kaplan, Joshua B Parsons, 2013, Antimicrobial Agents and Chemotherapy.

Membrane Disruption by Antimicrobial Fatty Acids Releases Low-Molecular-Weight Proteins from Staphylococcus aureus

C. Rock, Joshua B Parsons, Matthew W. Frank, 2012, Journal of bacteriology.

erratum: A triclosan-resistant bacterial enzyme

Charles O. Rock, Richard J. Heath, R. Heath, 2000, Nature.

Feedback Regulation of Murine Pantothenate Kinase 3 by Coenzyme A and Coenzyme A Thioesters*

C. Rock, Yong-mei Zhang, S. Jackowski, 2005, Journal of Biological Chemistry.

Localization and regulation of mouse pantothenate kinase 2

C. Rock, A. Lykidis, Yong-mei Zhang, 2007, FEBS letters.

Consequences of reduced intracellular coenzyme A content in Escherichia coli

C. Rock, S. Jackowski, 1986, Journal of bacteriology.

Turnover of fatty acids in the 1-position of phosphatidylethanolamine in Escherichia coli.

C. Rock, 1984, The Journal of biological chemistry.

Crystal structure and allosteric regulation of the cytoplasmic Escherichia coli L-asparaginase I.

R. Heath, C. Rock, A. Nourse, 2007, Journal of molecular biology.

Role of Fatty Acid Kinase in Cellular Lipid Homeostasis and SaeRS-Dependent Virulence Factor Expression in Staphylococcus aureus

C. Rock, C. Subramanian, Matthew W. Frank, 2017, mBio.

Acyl Carrier Protein Reductase Inhibitor AFN-1252

C. Rock, N. Kaplan, Joshua B Parsons, 2013 .

Phospholipid synthesis in Escherichia coli. Characteristics of fatty acid transfer from acyl-acyl carrier protein to sn-glycerol 3-phosphate.

C. Rock, J. Cronan, S. Goelz, 1981, The Journal of biological chemistry.

Lysophosphatidylcholine attenuates the cytotoxic effects of the antineoplastic phospholipid 1-O-octadecyl-2-O-methyl-rac-glycero-3- phosphocholine

C. Rock, K. Boggs, S. Jackowski, 1995, The Journal of Biological Chemistry.

Lysophosphatidylcholine and 1-O-Octadecyl-2-O-Methyl-rac- Glycero-3-Phosphocholine Inhibit the CDP-Choline Pathway of Phosphatidylcholine Synthesis at the CTP:Phosphocholine Cytidylyltransferase Step (*)

C. Rock, K. Boggs, S. Jackowski, 1995, The Journal of Biological Chemistry.

Two aerobic pathways for the formation of unsaturated fatty acids in Pseudomonas aeruginosa

C. Rock, H. Schweizer, Yong-mei Zhang, 2006, Molecular microbiology.

DesT Coordinates the Expression of Anaerobic and Aerobic Pathways for Unsaturated Fatty Acid Biosynthesis in Pseudomonas aeruginosa

C. Rock, C. Subramanian, Yong-mei Zhang, 2009, Journal of bacteriology.

Branched-chain amino acid metabolism controls membrane phospholipid structure in Staphylococcus aureus

C. Rock, Matthew W. Frank, S. Whaley, 2021, The Journal of biological chemistry.

Discovery of novel bacterial elongation condensing enzyme inhibitors by virtual screening.

C. Rock, Weixing Zhang, Richard E. Lee, 2014, Bioorganic & medicinal chemistry letters.

Biochemical Roles for Conserved Residues in the Bacterial Fatty Acid-binding Protein Family*

C. Rock, A. Nourse, S. White, 2016, The Journal of Biological Chemistry.

Domain architecture and catalysis of the Staphylococcus aureus fatty acid kinase

C. Rock, C. Subramanian, S. White, 2022, The Journal of biological chemistry.

Competence-Associated Peptide BriC Alters Fatty Acid Biosynthesis in Streptococcus pneumoniae

C. Rock, Surya D. Aggarwal, J. Gullett, 2021 .

Competence-Associated Peptide BriC Alters Fatty Acid Biosynthesis in Streptococcus pneumoniae

C. Rock, Surya D. Aggarwal, N. Hiller, 2021, bioRxiv.

Pank1 deletion in leptin-deficient mice reduces hyperglycaemia and hyperinsulinaemia and modifies global metabolism without affecting insulin resistance

C. Rock, S. Jackowski, Roberta Leonardi, 2014, Diabetologia.

Serum Opacity Factor, a Streptococcal Virulence Factor That Binds to Apolipoproteins A-I and A-II and Disrupts High Density Lipoprotein Structure*

C. Rock, Yong-mei Zhang, H. Courtney, 2006, Journal of Biological Chemistry.

Elimination of the CDP-ethanolamine Pathway Disrupts Hepatic Lipid Homeostasis*

C. Rock, S. Jackowski, Matthew W. Frank, 2009, The Journal of Biological Chemistry.

Phosphatidylcholine hydrolysis and c-myc expression are in collaborating mitogenic pathways activated by colony-stimulating factor 1

C. Rock, S. Jackowski, X. X. Xu, 1993, Molecular and cellular biology.

Pantothenate Kinase 1 Is Required to Support the Metabolic Transition from the Fed to the Fasted State

C. Rock, J. Rehg, S. Jackowski, 2010, PloS one.

Stimulation of phosphatidylinositol 4,5-bisphosphate phospholipase C activity by phosphatidic acid.

C. Rock, S. Jackowski, 1989, Archives of biochemistry and biophysics.

Macrophage growth arrest by cyclic AMP defines a distinct checkpoint in the mid-G1 stage of the cell cycle and overrides constitutive c-myc expression

C. Rock, J. Cleveland, S. Jackowski, 1992, Molecular and cellular biology.

Oleate Hydratase (OhyA) Is a Virulence Determinant in Staphylococcus aureus

C. Rock, J. Rosch, Matthew W. Frank, 2021, Microbiology spectrum.

Competence-Associated Peptide BriC Alters Fatty Acid Biosynthesis in Streptococcus pneumoniae

C. Rock, Surya D. Aggarwal, N. Hiller, 2021, bioRxiv.

Sonic Hedgehog Activates Phospholipase A2 to Enhance Smoothened Ciliary Translocation.

C. Rock, S. Ogden, Miriam E. Dillard, 2017, Cell reports.

Complementation of growth factor receptor-dependent mitogenic signaling by a truncated type I phosphatidylinositol 4-phosphate 5-kinase

M. Roussel, C. Rock, R. Ashmun, 1997, Molecular and cellular biology.

Maternal bile acid transporter deficiency promotes neonatal demise

C. Rock, Fei Li, G. Neale, 2015, Nature Communications.

Metabolic adaptations underpin resistance to histone acetyltransferase inhibition

Christopher J. Ott, C. Rock, C. Subramanian, 2022, bioRxiv.

Homeostasis Pathway Disrupts Hepatic Lipid Elimination of the CDP-ethanolamine Regulation , and Signaling : Lipids and Lipoproteins : Metabolism

C. Rock, Matthew W. Frank, Pamela, 2009 .

b -Ketoacyl-Acyl Carrier Protein Synthase III (FabH) Is a Determining Factor in Branched-Chain Fatty Acid Biosynthesis

R. Heath, C. Rock, Keum-Hwa Choi, 1999 .

Molecular properties of acyl carrier protein derivatives.

C. Rock, J. Cronan, I. Armitage, 1981, The Journal of biological chemistry.

Asymmetric localization of alkyldihydroxyacetone-P synthase and acyldihydroxyacetone-P acyltransferase in microsomal vesicles.

C. Rock, F. Snyder, 1978, Advances in experimental medicine and biology.

Activation of alkyldihydroxyacetone phosphate synthase by detergents.

C. Rock, F. Snyder, V. Fitzgerald, 1977, Archives of biochemistry and biophysics.

The antiproliferative effect of hexadecylphosphocholine toward HL60 cells is prevented by exogenous lysophosphatidylcholine.

C. Rock, K. Boggs, S. Jackowski, 1998, Biochimica et biophysica acta.

Rapid purification of phospholipase A2 from Crotalus adamanteus venom by affinity chromatography.

C. Rock, F. Snyder, 1975, The Journal of biological chemistry.

Thrombin- and nucleotide-activated phosphatidylinositol 4,5-bisphosphate phospholipase C in human platelet membranes.

C. Rock, S. Jackowski, 1987, The Journal of biological chemistry.

Biochemical characterization of the first step in sulfonolipid biosynthesis in Alistipes finegoldii

C. Rock, Darcie J. Miller, Matthew W. Frank, 2022, The Journal of biological chemistry.

A guanine nucleotide-dependent phosphatidylinositol 4,5-diphosphate phospholipase C in cells transformed by the v-fms and v-fes oncogenes.

C. Rock, C. Sherr, S. Jackowski, 1986, The Journal of biological chemistry.

Structural features of the colony‐stimulating factor 1 receptor that affect its association with phosphatidylinositol 3‐kinase.

J. Downing, S. Shurtleff, C. Rock, 1990, The EMBO journal.

The FadRzDNA Complex TRANSCRIPTIONAL CONTROL OF FATTY ACID METABOLISM IN ESCHERICHIA COLI*

R. Heath, C. Rock, S. White, 2001 .

Structural basis for the feedback regulation of Escherichia coli pantothenate kinase by coenzyme A.

C. Rock, S. Jackowski, C. Park, 2000, The Journal of biological chemistry.

Activation of human mitochondrial pantothenate kinase 2 by palmitoylcarnitine

C. Rock, Yong-mei Zhang, S. Jackowski, 2007, Proceedings of the National Academy of Sciences.

Biochemical characterization of the ﬁ rst step in sulfonolipid biosynthesis in Alistipes ﬁ negoldii

C. Rock, Darcie J. Miller, Matthew W. Frank, 2022 .

PqsD Is Responsible for the Synthesis of 2,4-Dihydroxyquinoline, an Extracellular Metabolite Produced by Pseudomonas aeruginosa*

C. Rock, Yong-mei Zhang, Kun Zhu, 2008, Journal of Biological Chemistry.

Transcriptional regulation in bacterial membrane lipid synthesis This work was supported by National Institutes of Health Grant GM-34496, Cancer Center Support Grant (CORE) Grant CA21765, and the American Lebanese Associated Charities. Published, JLR Papers in Press, October 21, 2008.

C. Rock, Yong-mei Zhang, 2009, Journal of Lipid Research.

The PanK2 Genes of Mouse and Human Specify Proteins with DistinctSubcellular Locations

C. Rock, O. Ilkayeva, C. Newgard, 2007 .

The FadR.DNA complex. Transcriptional control of fatty acid metabolism in

R. Heath, C. Rock, S. White, 2001 .

Acyl-sulfamates target the essential glycerol-phosphate acyltransferase (PlsY) in Gram-positive bacteria.

C. Rock, V. Luna, Richard E. Lee, 2012, Bioorganic & medicinal chemistry.

RhlA Converts (cid:2) -Hydroxyacyl-Acyl Carrier Protein Intermediates in Fatty Acid Synthesis to the (cid:2) -Hydroxydecanoyl- (cid:2) -Hydroxydecanoate Component of Rhamnolipids in Pseudomonas aeruginosa (cid:1)

C. Rock, Kun Zhu, 2008 .

Lysophospholipid Flipping across the Escherichia coli Inner Membrane Catalyzed by a Transporter (LplT) Belonging to the Major Facilitator Superfamily*

C. Rock, M. Saier, Zhongge Zhang, 2005, Journal of Biological Chemistry.

The Role of CDP-Diacylglycerol Synthetase and Phosphatidylinositol Synthase Activity Levels in the Regulation of Cellular Phosphatidylinositol Content*

C. Rock, A. Lykidis, S. Jackowski, 1997, The Journal of Biological Chemistry.

Chlamydia trachomatis Scavenges Host Fatty Acids for Phospholipid Synthesis via an Acyl-Acyl Carrier Protein Synthetase*

C. Rock, Matthew W. Frank, Jiangwei Yao, 2015, The Journal of Biological Chemistry.

Structure-activity relationships at the 5-position of thiolactomycin: an intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli.

C. Rock, Yong-mei Zhang, S. White, 2006, Journal of medicinal chemistry.

Deregulated c-myc expression overrides IFN gamma-induced macrophage growth arrest.

C. Rock, S. Rockman, P. Vadiveloo, 1995, Oncogene.

The gene for murine CTP:phosphocholine cytidylyltransferase (Ctpct) is located on mouse chromosome 16.

N. Copeland, D. Gilbert, N. Jenkins, 1993, Genomics.

Erratum: Cloning of a novel phosphoprotein regulated by colony-stimulating factor 1 shares a domain with the Drosophila disabled gene product (Journal of Biological Chemistry (1995) 270 (14184-14191))

Xiang Xu, C. Rock, S. Jackowski, 1996 .

Roles of the Active Site Water, Histidine 303, and Phenylalanine 396 in the Catalytic Mechanism of the Elongation Condensing Enzyme of Streptococcus pneumoniae*

C. Rock, Yong-mei Zhang, S. White, 2006, Journal of Biological Chemistry.

The Structure of (3R)-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ) from Pseudomonas aeruginosa*

K. Fiebig, C. Rock, M. Vedadi, 2004, Journal of Biological Chemistry.

Cofactor-induced conformational rearrangements establish a catalytically competent active site and a proton relay conduit in FabG.

C. Rock, Yong-mei Zhang, S. White, 2004, Structure.

The Claisen condensation in biology.

Charles O. Rock, Richard J. Heath, R. Heath, 2002, Natural product reports.

Structure of RhlG, an Essential β-Ketoacyl Reductase in the Rhamnolipid Biosynthetic Pathway of Pseudomonas aeruginosa*

C. Rock, Yong-mei Zhang, S. White, 2006, Journal of Biological Chemistry.

The 1.8 A crystal structure and active-site architecture of beta-ketoacyl-acyl carrier protein synthase III (FabH) from escherichia coli.

R. Heath, C. Rock, S. White, 2000, Structure.

Inhibition of β-Ketoacyl-Acyl Carrier Protein Synthases by Thiolactomycin and Cerulenin

R. Heath, C. Rock, S. White, 2001, The Journal of Biological Chemistry.

A High-Throughput Screen Reveals New Small-Molecule Activators and Inhibitors of Pantothenate Kinases

Asli N. Goktug, C. Rock, Taosheng Chen, 2015, Journal of medicinal chemistry.

Chemical Exchanges between Multilateral Symbionts.

C. Rock, J. Clardy, D. Andes, 2021, Organic letters.

Regulation of Bacterial Membrane Lipid Synthesis

C. Rock, J. Cronan, 1982 .

Inhibition of the Staphylococcus aureusNADPH-dependent Enoyl-Acyl Carrier Protein Reductase by Triclosan and Hexachlorophene*

R. Heath, C. Rock, G. E. Roland, 2000, The Journal of Biological Chemistry.

Lipid biosynthesis as a target for antibacterial agents.

R J Heath, R. Heath, C. Rock, 2001, Progress in lipid research.

Mechanism of Triclosan Inhibition of Bacterial Fatty Acid Synthesis*

R J Heath, D. R. Holland, R. Heath, 1999, The Journal of Biological Chemistry.

Identification and substrate specificity of beta -ketoacyl (acyl carrier protein) synthase III (mtFabH) from Mycobacterium tuberculosis.

C. Rock, G. Besra, L. Kremer, 2000, The Journal of biological chemistry.

Fatty acid activation and utilization by Alistipes finegoldii, a representative Bacteroidetes resident of the human gut microbiome

C. Rock, Matthew W. Frank, Jiangwei Yao, 2019, Molecular microbiology.

Regulation of Malonyl-CoA Metabolism by Acyl-Acyl Carrier Protein and β-Ketoacyl-Acyl Carrier Protein Synthases in Escherichia coli(*)

R J Heath, R. Heath, C. Rock, 1995, The Journal of Biological Chemistry.

Evaluation of Epigallocatechin Gallate and Related Plant Polyphenols as Inhibitors of the FabG and FabI Reductases of Bacterial Type II Fatty-acid Synthase*

C. Rock, Yong-mei Zhang, 2004, Journal of Biological Chemistry.

Forty years of bacterial fatty acid synthesis.

C. Rock, S. Jackowski, Suzanne Jackowski, 2002, Biochemical and biophysical research communications.

Structure of beta-ketoacyl-[acyl carrier protein] reductase from Escherichia coli: negative cooperativity and its structural basis.

C. Rock, S. White, S W White, 2001, Biochemistry.

Escherichia coli as a model for the regulation of dissociable (type II) fatty acid biosynthesis.

C. Rock, J. Cronan, Charles O. Rock, 1996, Biochimica et biophysica acta.

Inhibition of -Ketoacyl-Acyl Carrier Protein Synthase III (FabH) by Acyl-Acyl Carrier Protein in Escherichia coli(*)

R. Heath, C. Rock, 1996, The Journal of Biological Chemistry.

Regulation of Fatty Acid Elongation and Initiation by Acyl-Acyl Carrier Protein in Escherichia coli(*)

R. Heath, C. Rock, 1996, The Journal of Biological Chemistry.

Bacterial lipids: metabolism and membrane homeostasis.

C. Rock, Joshua B Parsons, Joshua B. Parsons, 2013, Progress in lipid research.

Coenzyme A: back in action.

C. Rock, Yong-mei Zhang, S. Jackowski, 2005, Progress in lipid research.

Relief of CoA sequestration and restoration of mitochondrial function in a mouse model of propionic acidemia

C. Rock, C. Subramanian, S. White, 2022, Journal of inherited metabolic disease.

Pantothenate kinase activation relieves coenzyme A sequestration and improves mitochondrial function in mice with propionic acidemia

C. Rock, C. Subramanian, S. White, 2021, Science Translational Medicine.

Role of spermidine in the activity of sn-glycerol-3-phosphate acyltransferase from Escherichia coli.

C. Rock, D. Vallari, 1982, Archives of biochemistry and biophysics.

ATP stimulation of the sn-glycerol-3-phosphate acyltransferase of Escherichia coli.

C. Rock, J. Cronan, S. Goelz, 1981, Archives of biochemistry and biophysics.

Product diversity and regulation of type II fatty acid synthases.

C. Rock, Yong-mei Zhang, Ying-Jie Lu, 2004, Biochemistry and cell biology = Biochimie et biologie cellulaire.

Localization of acyl carrier protein in Escherichia coli

C. Rock, S. Jackowski, H. Edwards, 1985, Journal of bacteriology.

Pyruvate Oxidase as a Critical Link between Metabolism and Capsule Biosynthesis in Streptococcus pneumoniae

C. Rock, Ti-Cheng Chang, A. Iverson, 2016, PLoS pathogens.

Inhibiting Bacterial Fatty Acid Synthesis*

C. Rock, Yong-mei Zhang, S. White, 2006, Journal of Biological Chemistry.

Identification of a Soluble Diacylglycerol Kinase Required for Lipoteichoic Acid Production in Bacillus subtilis*

C. Rock, D. de Mendoza, G. Schujman, 2007, Journal of Biological Chemistry.

Regulation of coenzyme A biosynthesis

C. Rock, S. Jackowski, 1981, Journal of bacteriology.

Environment of the aromatic chromophores of acyl carrier protein.

C. Rock, C O Rock, 1983, Archives of biochemistry and biophysics.

Improved purification of acyl carrier protein.

C. Rock, J. Cronan, 1980, Analytical biochemistry.

Fatty acid and phospholipid metabolism in prokaryotes

C. Rock, 2008 .

Chapter 3 Fatty acid and phospholipid metabolism in prokaryotes

R. Heath, C. Rock, S. Jackowski, 2002 .

Phosphatidic acid synthesis in bacteria.

C. Rock, Jiangwei Yao, 2013, Biochimica et biophysica acta.

Transcriptional Regulation of Membrane Lipid Homeostasis in Escherichia coli*

C. Rock, Yong-mei Zhang, Kun Zhu, 2009, The Journal of Biological Chemistry.

Domain Swapping between Enterococcus faecalis FabN and FabZ Proteins Localizes the Structural Determinants for Isomerase Activity*

C. Rock, S. White, Ying-Jie Lu, 2005, Journal of Biological Chemistry.

The application of computational methods to explore the diversity and structure of bacterial fatty acid synthase Published, JLR Papers in Press, November 4, 2002. DOI 10.1194/jlr.R200016-JLR200

C. Rock, Yong-mei Zhang, S. White, 2003, Journal of Lipid Research.

A New Mechanism for Anaerobic Unsaturated Fatty Acid Formation inStreptococcus pneumoniae *

Charles O. Rock, C. Rock, H. Marrakchi, 2002, The Journal of Biological Chemistry.

Metabolism of 4'-phosphopantetheine in Escherichia coli

C. Rock, S. Jackowski, 1984, Journal of bacteriology.

Mixed disulfides of acyl carrier protein and coenzyme A with specific soluble proteins in Escherichia coli

C. Rock, 1982, Journal of bacteriology.

Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis.

C. Rock, O. Ilkayeva, C. Newgard, 2007, Chemistry & biology.

Structure-activity relationships and enzyme inhibition of pantothenamide-type pantothenate kinase inhibitors.

C. Rock, K. Hevener, Yong-mei Zhang, 2006, Bioorganic & medicinal chemistry.

A Pantothenate Kinase from Staphylococcus aureus Refractory to Feedback Regulation by Coenzyme A*

C. Rock, Yong-mei Zhang, S. Jackowski, 2005, Journal of Biological Chemistry.

Role of Feedback Regulation of Pantothenate Kinase (CoaA) in Control of Coenzyme A Levels in Escherichia coli

C. Rock, S. Jackowski, Hee-won Park, 2003, Journal of bacteriology.

Pantothenate transport in Escherichia coli

C. Rock, D. Vallari, 1985, Journal of bacteriology.

Acyl Carrier Protein Is a Cellular Target for the Antibacterial Action of the Pantothenamide Class of Pantothenate Antimetabolites*

C. Rock, Yong-mei Zhang, S. Jackowski, 2004, Journal of Biological Chemistry.

[41] Acyl carrier protein from Escherichia coli☆

C. Rock, J. Cronan, 1981 .

Acyl carrier protein from Escherichia coli.

C. Rock, J. Cronan, 1981, Methods in enzymology.

Re-evaluation of the solution structure of acyl carrier protein.

C. Rock, J. Cronan, 1979, The Journal of biological chemistry.

Transfer of fatty acids from the 1-position of phosphatidylethanolamine to the major outer membrane lipoprotein of Escherichia coli.

C. Rock, S. Jackowski, 1986, The Journal of biological chemistry.

Therapeutic Targets in Chlamydial Fatty Acid and Phospholipid Synthesis

C. Rock, Jiangwei Yao, 2018, Front. Microbiol..

Exogenous fatty acid metabolism in bacteria.

C. Rock, Jiangwei Yao, 2017, Biochimie.

Chlamydia trachomatis Relies on Autonomous Phospholipid Synthesis for Membrane Biogenesis*♦

C. Rock, Matthew W. Frank, Jiangwei Yao, 2015, The Journal of Biological Chemistry.

Incorporation and turnover of fatty acids in Escherichia coli membrane phospholipids

C. Rock, S. Jackowski, 1996 .

[13] 2-Acylglycerophosphoethanolamine acyltransferase/ acyl-[acyl-carrier-protein] synthetase from Escherichia coli

C. Rock, S. Jackowski, L. Hsu, 1992 .

Chapter 2 Lipid metabolism in procrayotes

C. Rock, J. Cronan, S. Jackowski, 1991 .

Uptake and acylation of 2-acyl-lysophospholipids by Escherichia coli

C. Rock, S. Jackowski, L. Hsu, 1989, Journal of bacteriology.

Membrane lipid homeostasis in bacteria

C. Rock, Yong-mei Zhang, 2008, Nature Reviews Microbiology.

Inositol metabolism and cell growth in a Chinese hamster ovary cell myo-inositol auxotroph.

C. Rock, D. Voelker, S. Jackowski, 1988, The Journal of biological chemistry.

Broad Spectrum Antimicrobial Biocides Target the FabI Component of Fatty Acid Synthesis*

R. Heath, C. Rock, M. Shapiro, 1998, The Journal of Biological Chemistry.

Properties of dihydroxyacetone phosphate acyltransferase in the harderian gland.

C. Rock, F. Snyder, V. Fitzgerald, 1977, The Journal of biological chemistry.

Biosynthesis of Membrane Lipids.

C. Rock, J. Cronan, 2008, EcoSal Plus.

Roles of the FabA and FabZ β-Hydroxyacyl-Acyl Carrier Protein Dehydratases in Escherichia coli Fatty Acid Biosynthesis*

R. Heath, C. Rock, 1996, The Journal of Biological Chemistry.

2-Acylglycerolphosphoethanolamine acyltransferase/acyl-acyl carrier protein synthetase is a membrane-associated acyl carrier protein binding protein.

C. Rock, S. Jackowski, C. L. Cooper, 1989, The Journal of biological chemistry.

Pathways for the incorporation of exogenous fatty acids into phosphatidylethanolamine in Escherichia coli.

C. Rock, S. Jackowski, 1985, The Journal of biological chemistry.

Solubilization, purification, and salt activation of acyl-acyl carrier protein synthetase from Escherichia coli.

C. Rock, J. Cronan, 1979, The Journal of biological chemistry.

Preparative enzymatic synthesis and hydrophobic chromatography of acyl-acyl carrier protein.

C. Rock, J. Garwin, 1979, The Journal of biological chemistry.

A thioesterase bypasses the requirement for exogenous fatty acids in the plsX deletion of Streptococcus pneumoniae

C. Rock, J. Schalkwijk, M. Jonge, 2015, Molecular microbiology.

Disabled‐2 is transcriptionally regulated by ICSBP and augments macrophage spreading and adhesion

F. Rosenbauer, K. Knobeloch, C. Rock, 2002, The EMBO journal.

The presence of linoleic acid in Escherichia coli cannot be confirmed

C. Rock, J. Cronan, 1994, Journal of bacteriology.

FabH selectivity for anteiso branched-chain fatty acid precursors in low-temperature adaptation in Listeria monocytogenes.

C. Rock, A. Singh, C. Subramanian, 2009, FEMS microbiology letters.

RelA Mutant Enterococcus faecium with Multiantibiotic Tolerance Arising in an Immunocompromised Host

C. Rock, V. Cooper, J. Rubnitz, 2017, mBio.

Activation of Exogenous Fatty Acids to Acyl-Acyl Carrier Protein Cannot Bypass FabI Inhibition in Neisseria*

C. Rock, Richard E. Lee, Matthew W. Frank, 2015, The Journal of Biological Chemistry.

Opening a New Path to Lipoic Acid

C. Rock, 2009, Journal of bacteriology.

A Conserved Histidine Is Essential for Glycerolipid Acyltransferase Catalysis

R. Heath, C. Rock, 1998, Journal of bacteriology.

Colony-stimulating factor 1 regulates CTP: phosphocholine cytidylyltransferase mRNA levels.

C. Rock, S. Jackowski, R. Cornell, 1991, The Journal of biological chemistry.

Dual roles for the Dab2 adaptor protein in embryonic development and kidney transport

Jonathan A. Cooper, C. Rock, M. Tallquist, 2002, The EMBO journal.

A genome-wide atlas of antibiotic susceptibility targets and pathways to tolerance

C. Rock, J. Rosch, B. Jana, 2022, Nature Communications.

Human pantothenate kinase 4 is a pseudo‐pantothenate kinase

C. Rock, C. Subramanian, S. Jackowski, 2019, Protein science : a publication of the Protein Society.

Acyl-phosphates initiate membrane phospholipid synthesis in Gram-positive pathogens.

C. Rock, Yong-mei Zhang, Richard E. Lee, 2006, Molecular cell.

A bacterial pan-genome makes gene essentiality strain-dependent and evolvable

C. Rock, Defne Surujon, J. Rosch, 2022, bioRxiv.

Cancer-associated Isocitrate Dehydrogenase Mutations Inactivate NADPH-dependent Reductive Carboxylation*

C. Rock, C. Subramanian, S. Jackowski, 2012, The Journal of Biological Chemistry.

Characterization of Streptococcus pneumoniae enoyl-(acyl-carrier protein) reductase (FabK).

R. Heath, C. Rock, N. Wallis, 2003, The Biochemical journal.

Acyl-chain selectivity and physiological roles of Staphylococcus aureus fatty acid–binding proteins

C. Rock, C. Subramanian, S. White, 2018, The Journal of Biological Chemistry.

Phosphatidylcholine signaling in response to CSF‐1

C. Rock, Xiang-Xi Xu, S. Jackowski, 1997, Molecular reproduction and development.

Isolation and characterization of temperature-sensitive pantothenate kinase (coaA) mutants of Escherichia coli

C. Rock, D. Vallari, 1987, Journal of bacteriology.

Movement of triglycerides and monoglycerides across the intestine of Ascaris suum.

H. H. Bailey, C. Rock, C. G. Beames, 1974, Comparative biochemistry and physiology. A, Comparative physiology.

Movement of cholesterol and β-sitosterol across the intestine of Ascaris suum☆

H. H. Bailey, C. Rock, C. G. Beames, 1974 .

Sustained generation of nitric oxide and control of mycobacterial infection requires argininosuccinate synthase 1.

C. Rock, A. Smith, T. Decker, 2012, Cell host & microbe.

Acyl-Acyl Carrier Protein Regulates Transcription of Fatty Acid Biosynthetic Genes via the FabT Repressor in Streptococcus pneumoniae*

C. Rock, A. Jerga, Agoston Jerga, 2009, The Journal of Biological Chemistry.

Transcriptional regulation of fatty acid biosynthesis in Streptococcus pneumoniae

C. Rock, Ying-Jie Lu, 2006, Molecular microbiology.

The murine pantothenate kinase (Pank1) gene encodes two differentially regulated pantothenate kinase isozymes.

C. Rock, Yong-mei Zhang, S. Jackowski, 2002, Gene.

Disruption of Glycolysis by Nutritional Immunity Activates a Two-Component System That Coordinates a Metabolic and Antihost Response by Staphylococcus aureus

C. Rock, T. Kehl-Fie, Jiangwei Yao, 2019, mBio.

β-Ketoacyl-Acyl Carrier Protein Synthase III (FabH) Is a Determining Factor in Branched-Chain Fatty Acid Biosynthesis

Charles O. Rock, Richard J. Heath, R. Heath, 2000, Journal of bacteriology.

Is bacterial fatty acid synthesis a valid target for antibacterial drug discovery?

C. Rock, Joshua B. Parsons, 2011, Current opinion in microbiology.

Guanosine tetraphosphate inhibition of fatty acid and phospholipid synthesis in Escherichia coli is relieved by overexpression of glycerol-3-phosphate acyltransferase (plsB).

R. Heath, C. Rock, S. Jackowski, 1994, The Journal of biological chemistry.

Biochemical Properties of Human Pantothenate Kinase 2 Isoforms and Mutations Linked to Pantothenate Kinase-associated Neurodegeneration*

C. Rock, Yong-mei Zhang, S. Jackowski, 2006, Journal of Biological Chemistry.

A Missense Mutation Accounts for the Defect in the Glycerol-3-Phosphate Acyltransferase Expressed in theplsB26 Mutant

R. Heath, C. Rock, 1999, Journal of bacteriology.

Response of Bacillus subtilis to Cerulenin and Acquisition of Resistance

C. Rock, D. de Mendoza, S. Altabe, 2001, Journal of bacteriology.

Malonyl-acyl carrier protein decarboxylase activity promotes fatty acid and cell envelope biosynthesis in Proteobacteria

C. Rock, C. Subramanian, Matthew W. Frank, 2021, The Journal of biological chemistry.

Fatty acid biosynthesis as a target for novel antibacterials.

R. Heath, C. Rock, 2004, Current opinion in investigational drugs.

Topology and Active Site of PlsY

C. Rock, Richard E. Lee, Fan Zhang, 2007, Journal of Biological Chemistry.

A gene (plsD) from Clostridium butyricum that functionally substitutes for the sn-glycerol-3-phosphate acyltransferase gene (plsB) of Escherichia coli

R. Heath, C. Rock, H. Goldfine, 1997, Journal of bacteriology.

Sequence and function of the aas gene in Escherichia coli.

C. Rock, S. Jackowski, P. Jackson, 1994, The Journal of biological chemistry.

Regulation of pantothenate kinase by coenzyme A and its thioesters.

C. Rock, S. Jackowski, D. Vallari, 1987, The Journal of biological chemistry.

Crystal Structures of the Dab Homology Domains of Mouse Disabled 1 and 2*

Jie J. Zheng, C. Rock, T. Curran, 2003, Journal of Biological Chemistry.

T Cells Encountering Myeloid Cells Programmed for Amino Acid-dependent Immunosuppression Use Rictor/mTORC2 Protein for Proliferative Checkpoint Decisions*

C. Rock, A. Smith, G. Neale, 2016, The Journal of Biological Chemistry.

Prostaglandin E2 inhibition of growth in a colony-stimulating factor 1-dependent macrophage cell line.

C. Rock, S. Jackowski, C. W. Rettenmier, 1990, The Journal of biological chemistry.

Resistance to AFN-1252 Arises from Missense Mutations in Staphylococcus aureus Enoyl-acyl Carrier Protein Reductase (FabI)*

C. Rock, Jiangwei Yao, J. B. Maxwell, 2013, The Journal of Biological Chemistry.

A Missense Mutation in the fabB (β-Ketoacyl-Acyl Carrier Protein Synthase I) Gene Confers Thiolactomycin Resistance to Escherichia coli

C. Rock, Yong-mei Zhang, S. White, 2002, Antimicrobial Agents and Chemotherapy.

Acetoacetyl-acyl carrier protein synthase. A target for the antibiotic thiolactomycin.

C. Rock, J. Cronan, S. Jackowski, 1989, The Journal of biological chemistry.

The FadR·DNA Complex

R. Heath, C. Rock, S. White, 2001, The Journal of Biological Chemistry.

Bacterial fatty acid metabolism in modern antibiotic discovery.

C. Rock, Jiangwei Yao, 2017, Biochimica et biophysica acta. Molecular and cell biology of lipids.

A Pathogen-Selective Antibiotic Minimizes Disturbance to the Microbiome

C. Rock, J. Rosch, R. Carter, 2016, Antimicrobial Agents and Chemotherapy.

Resistance Mechanisms and the Future of Bacterial Enoyl-Acyl Carrier Protein Reductase (FabI) Antibiotics.

C. Rock, Jiangwei Yao, 2016, Cold Spring Harbor perspectives in medicine.

How Bacterial Pathogens Eat Host Lipids: Implications for the Development of Fatty Acid Synthesis Therapeutics*

Charles O. Rock, C. Rock, Jiangwei Yao, 2015, The Journal of Biological Chemistry.

Crystal structure and allosteric regulation of the cytoplasmic Escherichia coli L-asparaginase I.

R. Heath, C. Rock, A. Nourse, 2007, Journal of molecular biology.

Analysis of the Staphylococcus aureus DgkB structure reveals a common catalytic mechanism for the soluble diacylglycerol kinases.

C. Rock, S. White, Darcie J. Miller, 2008, Structure.

Molecular Determinants for Interfacial Binding and Conformational Change in a Soluble Diacylglycerol Kinase*

C. Rock, S. White, Darcie J. Miller, 2009, Journal of Biological Chemistry.

Identification of structural transitions in bacterial fatty acid binding proteins that permit ligand entry and exit at membranes

E. Tajkhorshid, C. Rock, C. Subramanian, 2022, The Journal of biological chemistry.

Structural transitions permitting ligand entry and exit in bacterial fatty acid binding proteins

E. Tajkhorshid, C. Rock, C. Subramanian, 2021, bioRxiv.

Structure and mechanism of Staphylococcus aureus oleate hydratase (OhyA)

C. Rock, B. Young, Matthew W. Frank, 2020, The Journal of biological chemistry.

The genome of a Bacteroidetes inhabitant of the human gut encodes a structurally distinct enoyl-acyl carrier protein reductase (FabI)

C. Rock, J. Seetharaman, Darcie J. Miller, 2020, The Journal of Biological Chemistry.

Coupling of Fatty Acid and Phospholipid Synthesis in Bacillus subtilis

C. Rock, D. de Mendoza, Luciana Paoletti, 2007, Journal of bacteriology.

The Enoyl-[acyl-carrier-protein] Reductases FabI and FabL fromBacillus subtilis *

R. Heath, C. Rock, Nancy Su, 2000, The Journal of Biological Chemistry.

Phosphotransferase-mediated Transport of the Osmolyte 2-O-α-Mannosyl-d-glycerate in Escherichia coli Occurs by the Product of the mngA (hrsA) Gene and Is Regulated by the mngR (farR) Gene Product Acting as Repressor*

C. Rock, W. Boos, Maria-Manuel Sampaio, 2004, Journal of Biological Chemistry.

A σW‐dependent stress response in Bacillus subtilis that reduces membrane fluidity

C. Rock, J. Helmann, C. Subramanian, 2011, Molecular microbiology.

Metabolic basis for the differential susceptibility of Gram-positive pathogens to fatty acid synthesis inhibitors

Chitra Subramanian, C. Rock, C. Subramanian, 2011, Proceedings of the National Academy of Sciences.

Placental Thrombosis and Spontaneous Fetal Death in Mice Deficient in Ethanolamine Kinase 2*

C. Rock, S. Jackowski, Jina Wang, 2006, Journal of Biological Chemistry.

A therapeutic approach to pantothenate kinase associated neurodegeneration

C. Rock, C. Subramanian, S. White, 2018, Nature Communications.

Discovery of Bacterial Fatty Acid Synthase Type II Inhibitors Using a Novel Cellular Bioluminescent Reporter Assay

C. Rock, D. Moir, D. M. Mills, 2015, Antimicrobial Agents and Chemotherapy.

The 1.3-Angstrom-Resolution Crystal Structure of β-Ketoacyl-Acyl Carrier Protein Synthase II from Streptococcus pneumoniae

C. Rock, S. White, A. Price, 2003, Journal of bacteriology.

LipE guided discovery of isopropylphenyl pyridazines as pantothenate kinase modulators

C. Rock, C. Subramanian, S. White, 2021, Bioorganic & medicinal chemistry.

Allosteric Regulation of Mammalian Pantothenate Kinase*

C. Rock, C. Subramanian, S. White, 2016, The Journal of Biological Chemistry.

Ratio of active to inactive forms of acyl carrier protein in Escherichia coli.

C. Rock, S. Jackowski, 1983, The Journal of biological chemistry.

Pantothenate Kinase Regulation of the Intracellular Concentration of Coenzyme A*

C. Rock, S. Jackowski, R. B. Calder, 2000, The Journal of Biological Chemistry.

Observations on the Ligule of Selaginella fraiponti

C. Rock, R. Segal, 1973 .

Preparative enzymatic synthesis of acyl-acyl carrier protein.

C. Rock, J. Cronan, J. Garwin, 1981, Methods in enzymology.

Excess coenzyme A reduces skeletal muscle performance and strength in mice overexpressing human PANK2.

P. Stoilov, C. Rock, J. Rehg, 2017, Molecular genetics and metabolism.

Membrane Formation and Regulation

C. Rock, M. Ericson, 2016 .

The FabR (YijC) Transcription Factor Regulates Unsaturated Fatty Acid Biosynthesis in Escherichia coli *

C. Rock, Yong-mei Zhang, H. Marrakchi, 2002, The Journal of Biological Chemistry.

Fatty acid and phospholipid biosynthesis in prokaryotes

C. Rock, Yong-mei Zhang, 2021, Biochemistry of Lipids, Lipoproteins and Membranes.

Mechanistic diversity and regulation of Type II fatty acid synthesis.

C. Rock, H. Marrakchi, Y. Zhang, 2002, Biochemical Society transactions.

Will the Initiator of Fatty Acid Synthesis in Pseudomonas aeruginosa Please Stand Up?

C. Rock, Yong-mei Zhang, 2012, Journal of bacteriology.

Identification and Analysis of the Acyl Carrier Protein (ACP) Docking Site on β-Ketoacyl-ACP Synthase III*

R J Heath, A J Olson, A. Olson, 2001, The Journal of Biological Chemistry.

[21] Acyl-acyl carrier protein synthetase from Escherichia coli☆

C. Rock, J. Cronan, 1981 .

Incorporation of extracellular fatty acids by a fatty acid kinase‐dependent pathway in Staphylococcus aureus

C. Rock, C. Subramanian, Joshua B Parsons, 2014, Molecular microbiology.

Acyltransferases in bacterial glycerophospholipid synthesis

C. Rock, Yong-mei Zhang, 2008 .

The reductase steps of the type II fatty acid synthase as antimicrobial targets

C. Rock, Yong-mei Zhang, Ying-Jie Lu, 2004, Lipids.

Type II Fatty Acid Synthesis Is Essential for the Replication of Chlamydia trachomatis*

C. Rock, S. White, J. Cox, 2014, The Journal of Biological Chemistry.

The Solution Structure of Acyl Carrier Protein from Mycobacterium tuberculosis *

Jie J. Zheng, Gaohua Liu, C. Rock, 2002, The Journal of Biological Chemistry.

A two-helix motif positions the lysophosphatidic acid acyltransferase active site for catalysis within the membrane bilayer

C. Rock, E. Martin, S. White, 2017, Nature Structural &Molecular Biology.

A rainbow coalition of lipid transcriptional regulators

C. Rock, Yong-mei Zhang, 2010, Molecular microbiology.

Oleate hydratase from Staphylococcus aureus protects against palmitoleic acid, the major antimicrobial fatty acid produced by mammalian skin

C. Rock, C. Subramanian, Matthew W. Frank, 2019, The Journal of Biological Chemistry.

A short-chain acyl-CoA: 1-alkyl-2-acyl-sn-glycerol acyltrasnferase from a microsomal fraction of the rabbit Harderian gland.

C. Rock, F. Snyder, 1975, Biochimica et biophysica acta.

The Structural and Functional Basis for Recurring Sulfa Drug Resistance Mutations in Staphylococcus aureus Dihydropteroate Synthase

C. Rock, S. White, G. Kumar, 2018, Front. Microbiol..

Stimulation of the microsomal alkylglycerol monooxygenase by catalase.

C. Rock, F. Snyder, R. Baker, 1976, Biochimica et biophysica acta.

Cloning and Characterization of a Eukaryotic Pantothenate Kinase Gene (panK) from Aspergillus nidulans *

C. Rock, S. Jackowski, S. Unkles, 1999, The Journal of Biological Chemistry.

Mass spectral identification of 2-(O-acyl)hydroxy fatty acid esters in the white portion of the rabbit Harderian gland.

C. Rock, F. Snyder, W. T. Rainey, 1976, Chemistry and physics of lipids.

Metabolic interrelations of hydroxy-substituted ether-linked glycerolipids in the pink portion of the rabbit harderian gland.

C. Rock, F. Snyder, 1975, Archives of biochemistry and biophysics.

Acetoacetyl-acyl carrier protein synthase, a potential regulator of fatty acid biosynthesis in bacteria.

C. Rock, S. Jackowski, 1987, The Journal of biological chemistry.

A pantothenate kinase-deficient mouse model reveals a gene expression program associated with brain coenzyme a reduction.

C. Rock, C. Subramanian, S. Jackowski, 2020, Biochimica et biophysica acta. Molecular basis of disease.

Modulation of pantothenate kinase 3 activity by small molecules that interact with the substrate/allosteric regulatory domain.

C. Rock, Taosheng Chen, Yong-mei Zhang, 2010, Chemistry & biology.

Coupling of the biosynthesis of fatty acids and fatty alcohols.

C. Rock, F. Snyder, V. Fitzgerald, 1978, Archives of biochemistry and biophysics.

Mining Fatty Acid Biosynthesis for New Antimicrobials.

C. Rock, C. Radka, 2022, Annual review of microbiology.

Glycerolipid Acyltransferase Catalysis A Conserved Histidine Is Essential for

R. Heath, C. Rock, Charles O. Rock, 1997 .

Crystal Structures of Human Pantothenate Kinases

C. Rock, M. Vedadi, Yong-mei Zhang, 2007, Journal of Biological Chemistry.

Role of the pyruvate metabolic network on carbohydrate metabolism and virulence in Streptococcus pneumoniae

C. Rock, H. Echlin, J. Rosch, 2020, Molecular microbiology.

Correction of a genetic deficiency in pantothenate kinase 1 using phosphopantothenate replacement therapy.

C. Rock, S. Jackowski, Matthew W. Frank, 2015, Molecular genetics and metabolism.

Key Residues Responsible for Acyl Carrier Protein and β-Ketoacyl-Acyl Carrier Protein Reductase (FabG) Interaction*

Bainan Wu, Charles O. Rock, Jie J. Zheng, 2003, Journal of Biological Chemistry.

The Structure of the Pantothenate Kinase·ADP·Pantothenate Ternary Complex Reveals the Relationship between the Binding Sites for Substrate, Allosteric Regulator, and Antimetabolites*

C. Rock, K. Hevener, Yong-mei Zhang, 2004, Journal of Biological Chemistry.

Biosynthesis of 1-alkyl-sn-glycero-3-phosphate via adenosine triphosphate:1-alkyl-sn-glycerol phosphotransferase.

C. Rock, F. Snyder, 1974, The Journal of biological chemistry.

The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.

C. Rock, M. B. Waddell, S. White, 2014, Bioorganic & medicinal chemistry.

Lysophosphatidylglycerol (LPG) phospholipase D maintains membrane homeostasis in Staphylococcus aureus by converting LPG to lysophosphatidic acid

C. Rock, C. Subramanian, M. Yun, 2023, The Journal of biological chemistry.

A short-chain acyl-CoA synthetase that supports branched-chain fatty acid synthesis in Staphylococcus aureus

C. Rock, Matthew W. Frank, S. Whaley, 2023, The Journal of biological chemistry.

The Structural and Functional Basis for Recurring Sulfa Drug Resistance Mutations inStaphylococcus aureusDihydropteroate Synthase.

C. Rock, S. White, G. Kumar, 2018 .

Isolation and characterization of Escherichia coli pantothenate permease (panF) mutants

C. Rock, D. Vallari, 1985, Journal of bacteriology.

Turnover of the 4'-phosphopantetheine prosthetic group of acyl carrier protein.

C. Rock, S. Jackowski, 1984, The Journal of biological chemistry.

Lipid metabolism in prokaryotes

C. Rock, J. Cronan, S. Jackowski, 1996 .

A therapeutic approach to pantothenate kinase associated neurodegeneration

C. Rock, C. Subramanian, S. White, 2018, Nature Communications.

The structural biology of type II fatty acid biosynthesis.

Jie J. Zheng, C. Rock, Yong-mei Zhang, 2005, Annual review of biochemistry.

Acetyl-CoA biosynthesis drives resistance to histone acetyltransferase inhibition

Christopher J. Ott, C. Rock, C. Subramanian, 2023, Nature Chemical Biology.

Quantification of Coenzyme A in Cells and Tissues.

C. Rock, C. Subramanian, S. Jackowski, 2019, Journal of visualized experiments : JoVE.

Structure and Mechanism of CTP:Phosphocholine Cytidylyltransferase (LicC) from Streptococcus pneumoniae *

R. Heath, C. Rock, Yong-mei Zhang, 2002, The Journal of Biological Chemistry.

The licC Gene ofStreptococcus pneumoniae Encodes a CTP:Phosphocholine Cytidylyltransferase

R. Heath, C. Rock, S. Jackowski, 2001, Journal of bacteriology.

Enoyl-Acyl Carrier Protein Reductase I (FabI) Is Essential for the Intracellular Growth of Listeria monocytogenes

C. Rock, Matthew W. Frank, Jiangwei Yao, 2016, Infection and Immunity.

Proton magnetic resonance spectroscopy detects cerebral metabolic derangement in a mouse model of brain coenzyme a deficiency

C. Rock, C. Subramanian, P. Bagga, 2022, Journal of translational medicine.

C. Rock, Yong-mei Zhang, 2009, Journal of Lipid Research.

Staphylococcus aureus Dihydropteroate Synthase (saDHPS) F17L E208K double mutant structure

C. Rock, S. White, G. Kumar, 2018 .

Resistance to AFN-1252 Arises from Missense Mutations in Staphylococcus aureus Enoyl-acyl Carrier Protein Reductase (FabI)*

C. Rock, Jiangwei Yao, J. B. Maxwell, 2013, The Journal of Biological Chemistry.

How Bacterial Pathogens Eat Host Lipids: Implications for the Development of Fatty Acid Synthesis Therapeutics*

C. Rock, Jiangwei Yao, 2015, The Journal of Biological Chemistry.

Phosphatidic acid synthesis in bacteria.

C. Rock, Jiangwei Yao, 2013, Biochimica et biophysica acta.

Molecular Determinants for Interfacial Binding and Conformational Change in a Soluble Diacylglycerol Kinase*

C. Rock, S. White, Darcie J. Miller, 2009, Journal of Biological Chemistry.

Bacterial fatty acid metabolism in modern antibiotic discovery.

C. Rock, Jiangwei Yao, 2017, Biochimica et biophysica acta. Molecular and cell biology of lipids.

Activation of Exogenous Fatty Acids to Acyl-Acyl Carrier Protein Cannot Bypass FabI Inhibition in Neisseria*

C. Rock, Richard E. Lee, Matthew W. Frank, 2015, The Journal of Biological Chemistry.

Novel Acyl Phosphate Mimics that Target PlsY, an Essential Acyltransferase in Gram‐Positive Bacteria

C. Rock, Yong-mei Zhang, V. Luna, 2008, ChemMedChem.

Solution Structure of Acyl Carrier Protein

C. Rock, J. Cronan, 1982 .

Supplemental Data Prokaryotic Type II and Type III Pantothenate Kinases : The Same Monomer Fold Creates Dimers with Distinct Catalytic Properties

C. Rock, Yong-mei Zhang, S. White, 2006 .