S. Prigge

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The initiating steps of a type II fatty acid synthase in Plasmodium falciparum are catalyzed by pfACP, pfMCAT, and pfKASIII.

S. Prigge, Xin He, L. Gerena, 2003, Biochemistry.

Malaria pulls a FASt one.

S. Prigge, Maroya D. Spalding, 2008, Cell host & microbe.

Structure, evolution, and inhibitor interaction of S‐adenosyl‐L‐homocysteine hydrolase from Plasmodium falciparum

S. Prigge, J. Bujnicki, D. Caridha, 2003, Proteins.

Using a genome-scale metabolic network model to elucidate the mechanism of chloroquine action in Plasmodium falciparum

J. Reifman, A. Wallqvist, S. Prigge, 2017, International journal for parasitology. Drugs and drug resistance.

Static SIMS Studies of Metal-Covered W(110) Surfaces

S. Prigge, E. Bauer, 1979 .

Cyclin H activation and drug susceptibility of the Pfmrk cyclin dependent protein kinase from Plasmodium falciparum.

S. Prigge, N. Waters, C. Woodard, 2000, Molecular and biochemical parasitology.

Short-term metabolic adjustments in Plasmodium falciparum counter hypoxanthine deprivation at the expense of long-term viability

J. Reifman, A. Wallqvist, S. Prigge, 2019, Malaria journal.

Studies of Toxoplasma gondii and Plasmodium falciparum enoyl acyl carrier protein reductase and implications for the development of antiparasitic agents

D. Rice, S. Prigge, C. Roberts, 2007, Acta crystallographica. Section D, Biological crystallography.

Relation between positional specificity and chirality in mammalian lipoxygenases

S. Prigge, L. Amzel, B. J. Gaffney, 1998, Nature Structural Biology.

New Class of Small Nonpeptidyl Compounds BlocksPlasmodium falciparum Development In Vitro by Inhibiting Plasmepsins

Dennis E. Kyle, John B. Dame, J. Dame, 2001, Antimicrobial Agents and Chemotherapy.

Novel Type II Fatty Acid Biosynthesis (FAS II) Inhibitors as Multistage Antimalarial Agents

G. Klebe, S. Prigge, M. Schlitzer, 2013, ChemMedChem.

Redox‐dependent lipoylation of mitochondrial proteins in Plasmodium falciparum

S. Prigge, C. F. Freel Meyers, K. Matthews, 2014, Molecular microbiology.

Influence of human p16(INK4) and p21(CIP1) on the in vitro activity of recombinant Plasmodium falciparum cyclin-dependent protein kinases.

S. Prigge, N. Waters, K. L. Le Roch, 2001, Biochemical and biophysical research communications.

Plasmodium falciparum acyl carrier protein crystal structures in disulfide‐linked and reduced states and their prevalence during blood stage growth

S. Prigge, J. Gallagher, 2010, Proteins.

Expression, purification and crystallization of the Plasmodium falciparum enoyl reductase.

D. Rice, S. Prigge, R. McLeod, 2003, Acta crystallographica. Section D, Biological crystallography.

Structure and mechanism of lipoxygenases.

S. Prigge, L. Amzel, J. Boyington, 1997, Biochimie.

The ferredoxin redox system - an essential electron distributing hub in the apicoplast of Apicomplexa.

S. Prigge, F. Seeber, Rubayet Elahi, 2022, Trends in parasitology.

Crystal structure of lipoate‐bound lipoate ligase 1, LipL1, from Plasmodium falciparum

S. Prigge, Alfredo J. Guerra, Gustavo A. Afanador, 2017, Proteins.

Amidation of bioactive peptides: the structure of peptidylglycine alpha-hydroxylating monooxygenase.

S. Prigge, R. Mains, L. Amzel, 1997, Science.

Development of a conditional localization approach to control apicoplast protein trafficking in malaria parasites

S. Prigge, Alfredo J. Guerra, S. Nair, 2019, Traffic.

Ceramide and Cerebroside from the stem bark of Ficus mucuso (Moraceae).

S. Prigge, A. E. Nkengfack, M. I. Choudhary, 2010, Chemical & pharmaceutical bulletin.

Fatty Acid Synthesis in Protozoan Parasites

S. Prigge, M. Allary, 2008 .

Oxindole-based compounds are selective inhibitors of Plasmodium falciparum cyclin dependent protein kinases.

Apurba K Bhattacharjee, S. Prigge, L. Gerena, 2003, Journal of medicinal chemistry.

Differential reactivity between two copper sites in peptidylglycine α-hydroxylating monooxygenase.

S. Prigge, R. Mains, L. Amzel, 2010, Journal of the American Chemical Society.

Amidation of bioactive peptides: The structure of peptidylglycine α-hydroxylating monooxygenase

S. Prigge, R. Mains, L. Amzel, 1998 .

Dioxygen Binds End-On to Mononuclear Copper in a Precatalytic Enzyme Complex

S. Prigge, R. Mains, L. Amzel, 2004, Science.

New insights into copper monooxygenases and peptide amidation: structure, mechanism and function

S. Prigge, R. Mains, L. Amzel, 2000, Cellular and Molecular Life Sciences CMLS.

Substrate-mediated electron transfer in peptidylglycine α-hydroxylating monooxygenase

S. Prigge, R. Mains, L. Amzel, 1999, Nature Structural Biology.

Modification of Triclosan Scaffold in Search of Improved Inhibitors for Enoyl‐Acyl Carrier Protein (ACP) Reductase in Toxoplasma gondii

D. Rice, S. Prigge, C. Roberts, 2013, ChemMedChem.

Lipoxygenases: Structure and Function

S. Prigge, L. Amzel, J. Boyington, 1996 .

Structure conservation in lipoxygenases: Structural analysis of soybean lipoxygenase‐1 and modeling of human lipoxygenases

S. Prigge, L. Amzel, J. Boyington, 1996, Proteins.

Isoflavone dimers and other bioactive constituents from the figs of Ficus mucuso.

S. Prigge, A. E. Nkengfack, M. Ali, 2011, Journal of natural products.

Specific heat of (BiPb)2Sr2Ca2Cu3O10−y from 78 to 300 K

J. E. Gordon, S. J. Collocott, S. Prigge, 1991 .

Lipoic Acid Metabolism in Microbial Pathogens

S. Prigge, Maroya D. Spalding, Sean T. Prigge, 2010, Microbiology and Molecular Biology Reviews.

Scavenging of the cofactor lipoate is essential for the survival of the malaria parasite Plasmodium falciparum

S. Prigge, Jeff Zhiqiang Lu, Liqun Zhu, 2007, Molecular microbiology.

Overexpression of biotin synthase and biotin ligase is required for efficient generation of sulfur-35 labeled biotin in E. coli

S. Prigge, Maroya D. Spalding, Teegan Delli-Bovi, 2010, BMC biotechnology.

Enzymes of type II fatty acid synthesis and apicoplast differentiation and division in Eimeria tenella.

D. Rice, S. Prigge, C. Roberts, 2007, International journal for parasitology.

The catalytic copper of peptidylglycine alpha-hydroxylating monooxygenase also plays a critical structural role.

S. Prigge, R. Mains, L. Amzel, 2005, Biophysical journal.

Metabolic responses in blood-stage malaria parasites associated with increased and decreased sensitivity to PfATP4 inhibitors

J. Reifman, A. Vaidya, A. Wallqvist, 2023, Malaria Journal.

Metabolic adjustments of blood-stage Plasmodium falciparum in response to sublethal pyrazoleamide exposure

J. Reifman, A. Vaidya, A. Wallqvist, 2022, Scientific Reports.

Transmissibility of clinically relevant atovaquone-resistant Plasmodium falciparum by anopheline mosquitoes

T. Shapiro, S. Prigge, P. Sinnis, 2023, bioRxiv.

The Amidase Domain of Lipoamidase Specifically Inactivates Lipoylated Proteins In Vivo

S. Prigge, Maroya D. Spalding, 2009, PloS one.

Maternal Inheritance and Stage-Specific Variation of the Apicoplast in Toxoplasma gondii during Development in the Intermediate and Definitive Host

D. Rice, S. Prigge, C. Roberts, 2005, Eukaryotic Cell.

Dephospho‐CoA kinase, a nuclear‐encoded apicoplast protein, remains active and essential after Plasmodium falciparum apicoplast disruption

S. Prigge, Krithika Rajaram, Russell P. Swift, 2021, The EMBO journal.

The NTP generating activity of pyruvate kinase II is critical for apicoplast maintenance in Plasmodium falciparum

S. Prigge, A. Jedlicka, Krithika Rajaram, 2020, eLife.

An update on the rapid advances in malaria parasite cell biology.

I. Coppens, D. Sullivan, S. Prigge, 2010, Trends in parasitology.

Ion Dose Effect in Thin Film Formation on Nb(100)

S. Prigge, E. Bauer, T. Koshikawa, 1984 .

Pd layers on A W(100) surface

S. Prigge, E. Bauer, H. Roux, 1981 .

Electron stimulated desorption ion energy distribution (ESDIED) and surface structure: O on W(100)

S. Prigge, E. Bauer, H. Niehus, 1978 .

Ion scattering spectroscopy of oxygen on tungsten (100)

S. Prigge, E. Bauer, H. Niehus, 1977 .

The condensation of lead on a gold {100} surface

S. Prigge, E. Bauer, A. Green, 1978 .

Identification of an effector protein and gain-of-function mutants that activate Pfmrk, a malarial cyclin-dependent protein kinase.

S. Prigge, N. Waters, D. Caridha, 2006, Molecular and biochemical parasitology.

Metabolic alterations in the erythrocyte during blood-stage development of the malaria parasite

J. Reifman, A. Wallqvist, S. Prigge, 2020, Malaria Journal.

Targeting malaria with specific CDK inhibitors.

S. Prigge, N. Waters, J. Geyer, 2005, Biochimica et biophysica acta.

Screening the Pathogen Box Compounds for Activity Against Plasmodium falciparum Sporozoite Motility

S. Prigge, P. Sinnis, Sachie Kanatani, 2022, bioRxiv.

Validation of a modified method for Bxb1 mycobacteriophage integrase-mediated recombination in Plasmodium falciparum by localization of the H-protein of the glycine cleavage complex to the mitochondrion.

S. Prigge, Maroya D. Spalding, J. Gallagher, 2010, Molecular and biochemical parasitology.

Roles of Ferredoxin-Dependent Proteins in the Apicoplast of Plasmodium falciparum Parasites

S. Prigge, Krithika Rajaram, Russell P. Swift, 2022, mBio.

Critical role for isoprenoids in apicoplast biogenesis by malaria parasites

S. Prigge, Krithika Rajaram, Russell P. Swift, 2021, bioRxiv.

Inter-study and time-dependent variability of metabolite abundance in cultured red blood cells

J. Reifman, A. Wallqvist, S. Prigge, 2021, Malaria journal.

Targeting the fatty acid biosynthesis enzyme, beta-ketoacyl-acyl carrier protein synthase III (PfKASIII), in the identification of novel antimalarial agents.

S. Prigge, L. Gerena, N. Waters, 2009, Journal of medicinal chemistry.

Identification and development of novel inhibitors of Toxoplasma gondii enoyl reductase.

D. Rice, S. Prigge, C. Roberts, 2010, Journal of medicinal chemistry.

Metabolic Survival Adaptations of Plasmodium falciparum Exposed to Sublethal Doses of Fosmidomycin

J. Reifman, A. Wallqvist, S. Prigge, 2021, Antimicrobial Agents and Chemotherapy.

Short-term metabolic adjustments in Plasmodium falciparum counter hypoxanthine deprivation at the expense of long-term viability

J. Reifman, A. Wallqvist, S. Prigge, 2019, Malaria journal.

The Suf Iron-Sulfur Cluster Synthesis Pathway Is Required for Apicoplast Maintenance in Malaria Parasites

S. Prigge, K. Matthews, Gundula Bosch, 2013, PLoS pathogens.

Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay.

Joel S. Freundlich, D. Rice, C. Fishwick, 2013, Biochemistry.

The mitochondrion of Plasmodium falciparum is required for cellular acetyl-CoA metabolism and protein acetylation

M. Llinás, S. Prigge, J. Munro, 2022, bioRxiv.

A three-dimensional in silico pharmacophore model for inhibition of Plasmodium falciparum cyclin-dependent kinases and discovery of different classes of novel Pfmrk specific inhibitors.

S. Prigge, N. Waters, J. Geyer, 2004, Journal of medicinal chemistry.

Novel N-Benzoyl-2-Hydroxybenzamide Disrupts Unique Parasite Secretory Pathway

D. Rice, S. Prigge, W. Witola, 2012, Antimicrobial Agents and Chemotherapy.

Lipoxygenase structure and mechanism.

S. Prigge, L. Amzel, J. Boyington, 1995, Advances in prostaglandin, thromboxane, and leukotriene research.

Targeting the lipid metabolic pathways for the treatment of malaria

Choukri Ben Mamoun, H. Vial, S. Prigge, 2009, Drug development research.

Type I and type II fatty acid biosynthesis in Eimeria tenella: enoyl reductase activity and structure

D. Rice, S. Prigge, C. Roberts, 2007, Parasitology.

Increased prevalence of the pfdhfr/phdhps quintuple mutant and rapid emergence of pfdhps resistance mutations at codons 581 and 613 in Kisumu, Kenya

S. Prigge, N. Waters, Maroya D. Spalding, 2010, Malaria Journal.

New insights into apicoplast metabolism in blood-stage malaria parasites.

S. Prigge, Rubayet Elahi, 2022, Current opinion in microbiology.

Substrate-mediated electron transfer in peptidylglycine alpha-hydroxylating monooxygenase.

S. Prigge, R. Mains, L. Amzel, 1999, Nature structural biology.

Parasites FeS Up: Iron-Sulfur Cluster Biogenesis in Eukaryotic Pathogens

S. Prigge, Jolyn E. Gisselberg, Teegan A. Dellibovi-Ragheb, 2013, PLoS pathogens.

A key role for lipoic acid synthesis during Plasmodium liver stage development

E. Winzeler, S. Prigge, D. Fidock, 2013, Cellular microbiology.

Design, synthesis, and biological activity of diaryl ether inhibitors of Toxoplasma gondii enoyl reductase.

D. Rice, S. Prigge, C. Roberts, 2013, Bioorganic & medicinal chemistry letters.

Metabolic adjustments of blood-stage Plasmodium falciparum in response to sublethal pyrazoleamide exposure

J. Reifman, A. Vaidya, A. Wallqvist, 2022, Scientific Reports.

A mevalonate bypass system facilitates elucidation of plastid biology in malaria parasites

A. Wallqvist, S. Prigge, Shivendra G. Tewari, 2020, PLoS pathogens.

Host biotin is required for liver stage development in malaria parasites

G. McFadden, S. Prigge, P. Sinnis, 2018, Proceedings of the National Academy of Sciences.

Metabolic alterations in the erythrocyte during blood-stage development of the malaria parasite

J. Reifman, A. Wallqvist, S. Prigge, 2020, Malaria Journal.

A redesigned TetR-aptamer system to control gene expression in Plasmodium falciparum

S. Prigge, Krithika Rajaram, Hans B. Liu, 2020, bioRxiv.

Screening the Pathogen Box for Inhibition of Plasmodium falciparum Sporozoite Motility Reveals a Critical Role for Kinases in Transmission Stages

S. Prigge, P. Sinnis, Sachie Kanatani, 2022, Antimicrobial agents and chemotherapy.

A novel lipoate attachment enzyme is shared by Plasmodium and Chlamydia species

S. Prigge, E. Freire, A. Schön, 2017, Molecular microbiology.

Metabolic changes accompanying the loss of fumarate hydratase and malate–quinone oxidoreductase in the asexual blood stage of Plasmodium falciparum

A. Wallqvist, S. Prigge, Shivendra G. Tewari, 2022, The Journal of biological chemistry.

The mitochondrion of Plasmodium falciparum is required for cellular acetyl-CoA metabolism and protein acetylation.

M. Llinás, S. Prigge, J. Munro, 2023, Proceedings of the National Academy of Sciences of the United States of America.

Redesigned TetR-Aptamer System To Control Gene Expression in Plasmodium falciparum

S. Prigge, Krithika Rajaram, Hans B. Liu, 2020, mSphere.

Functional characterization of the acyl carrier protein (PfACP) and beta-ketoacyl ACP synthase III (PfKASIII) from Plasmodium falciparum.

M. Gardner, S. Shallom, S. Prigge, 2002, Molecular and biochemical parasitology.

Delivery of antimicrobials into parasites

D. Rice, S. Prigge, C. Roberts, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Fatty Acid synthesis as a target for antimalarial drug discovery.

S. Prigge, N. Waters, Jeff Zhiqiang Lu, 2005, Combinatorial chemistry & high throughput screening.

Studies of Toxoplasma gondii and Plasmodium falciparum enoyl acyl carrier protein reductase and implications for the development of antiparasitic agents.

D. Rice, S. Prigge, C. Roberts, 2007 .

The Plasmodium falciparum apicoplast cysteine desulfurase provides sulfur for both iron-sulfur cluster assembly and tRNA modification

S. Prigge, Krithika Rajaram, Russell P. Swift, 2022, bioRxiv.

Plasmodium falciparum Apicoplast Transit Peptides are Unstructured in vitro and During Apicoplast Import

S. Prigge, J. Gallagher, K. Matthews, 2011, Traffic.

The benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme target.

D. Rice, C. Fishwick, S. Prigge, 2014, Bioorganic & medicinal chemistry letters.

A key role for lipoic acid synthesis during Plasmodium liver stage development

E. Winzeler, S. Prigge, D. Fidock, 2013, Cellular microbiology.

Using Lipoamidase as a Novel Probe To Interrogate the Importance of Lipoylation in Plasmodium falciparum

S. Prigge, M. Walters, Hugo Jhun, 2018, mBio.

Modification of Triclosan Scaffold in Search of Improved Inhibitors for Enoyl‐Acyl Carrier Protein (ACP) Reductase in Toxoplasma gondii

D. Rice, S. Prigge, C. Roberts, 2013, ChemMedChem.

Novel Type II Fatty Acid Biosynthesis (FAS II) Inhibitors as Multistage Antimalarial Agents

G. Klebe, S. Prigge, M. Schlitzer, 2013, ChemMedChem.

Development of a triclosan scaffold which allows for adaptations on both the A- and B-ring for transport peptides.

D. Rice, S. Prigge, R. McLeod, 2013, Bioorganic & medicinal chemistry letters.

Lipoxygenases: Structure and Function

S. Prigge, J. Boyington, B. J. Gaffney, 1996 .

Single Crystal Surface Structure Studies with Static SIMS

S. Prigge, E. Bauer, 1984 .

The tail of mycolic acids.

S. Prigge, Jeff Zhiqiang Lu, 2008, Chemistry & biology.

Lactococcus lactis fabH, Encoding β-Ketoacyl-Acyl Carrier Protein Synthase, Can Be Functionally Replaced by the Plasmodium falciparum Congener

S. Prigge, B. Bachmann, Jacob D. Johnson, 2010, Applied and Environmental Microbiology.

Lactococcus lactis fabH , Encoding (cid:1) -Ketoacyl-Acyl Carrier Protein Synthase, Can Be Functionally Replaced by the Plasmodium falciparum Congener (cid:1)

S. Prigge, B. Bachmann, Jacob D. Johnson, 2010 .