M. Schlitzer

发表

The plastid-like organelle of apicomplexan parasites as drug target.

J. Wiesner, H. Jomaa, A. Reichenberg, 2008, Current pharmaceutical design.

A Novel Short and Efficient Synthetic Route to the Antimalarial Agent FR900098 and Derivatives

M. Schlitzer, J. Perruchon, R. Ortmann, 2007 .

Derivatives of biarylalkyl carboxylic acid induce pleiotropic phenotypes in adult Schistosoma mansoni in vitro

M. Schlitzer, C. Grevelding, Zhigang Lu, 2016, Parasitology Research.

Novel Type II Fatty Acid Biosynthesis (FAS II) Inhibitors as Multistage Antimalarial Agents

G. Klebe, S. Prigge, M. Schlitzer, 2013, ChemMedChem.

Chemotherapy for Fighting Schistosomiasis: Past, Present and Future

M. Schlitzer, C. Grevelding, P. Mäder, 2018, ChemMedChem.

N‐Acyl Derivatives of 4‐Phenoxyaniline as Neuroprotective Agents

C. Culmsee, M. Schlitzer, S. Oppermann, 2014, ChemMedChem.

Non‐Thiol Farnesyltransferase Inhibitors: Utilization of the Far Aryl Binding Site by Arylthienylacryloylaminobenzophenones

M. Schlitzer, I. Sattler, A. Mitsch, 2005, Archiv der Pharmazie.

Non-thiol farnesyltransferase inhibitors: N-(4-acylamino-3-benzoylphenyl)-3-[5-(4-nitrophenyl)-2-furyl]acrylic acid amides.

G. Klebe, M. Schlitzer, I. Sattler, 2003, Bioorganic & medicinal chemistry.

Non-thiol farnesyltransferase inhibitors: utilization of an aryl binding site by 5-arylacryloylaminobenzophenones.

M. Schlitzer, I. Sattler, M. Böhm, 2002, Bioorganic & medicinal chemistry.

Synthesis and evaluation of homofarnesoyl-substituted CAAX-peptidomimetics as farnesyltransferase inhibitors and antiproliferative agents.

M. Schlitzer, I. Sattler, H. Dahse, 1999, Bioorganic & medicinal chemistry.

Disulfiram and dithiocarbamate analogues demonstrate promising antischistosomal effects.

M. Schlitzer, C. Grevelding, A. Grünweller, 2022, European journal of medicinal chemistry.

Development of Biarylalkyl Carboxylic Acid Amides with Improved Anti‐schistosomal Activity

M. Schlitzer, C. Grevelding, R. Hartmann, 2019, ChemMedChem.

Biarylalkyl Carboxylic Acid Derivatives as Novel Antischistosomal Agents

M. Schlitzer, C. Grevelding, R. Hartmann, 2016, ChemMedChem.

Non-thiol farnesyltransferase inhibitors: structure-activity relationships of benzophenone-based bisubstrate analogue farnesyltransferase inhibitors.

M. Schlitzer, I. Sattler, M. Böhm, 2002, Bioorganic & medicinal chemistry.

Aromatic carboxylic acids as farnesyl surrogates in farnesylpyrophosphate-based farnesyltransferase inhibitors.

M. Schlitzer, I. Sattler, 1999, Bioorganic & medicinal chemistry.

Non-thiol farnesyltransferase inhibitors: N-(4-Acylamino-3-benzoylphenyl)-4-nitrocinnamic acid amides.

M. Schlitzer, I. Sattler, J. Sakowski, 2002, Bioorganic & Medicinal Chemistry.

New antimalarial drugs.

Jochen Wiesner, J. Wiesner, H. Jomaa, 2003, Angewandte Chemie.

Synthesis, molecular modeling, and structure-activity relationship of benzophenone-based CAAX-peptidomimetic farnesyltransferase inhibitors.

M. Schlitzer, I. Sattler, H. Dahse, 2001, Journal of medicinal chemistry.

Acyloxyalkyl ester prodrugs of FR900098 with improved in vivo anti-malarial activity.

J. Wiesner, H. Jomaa, A. Reichenberg, 2003, Bioorganic & medicinal chemistry letters.

First In Silico Screening of Insect Molecules for Identification of Novel Anti-Parasitic Compounds

M. Schlitzer, A. Grünweller, C. Unverzagt, 2022, Pharmaceuticals.

Alkoxycarbonyloxyethyl Ester Prodrugs of FR900098 with Improved In Vivo Antimalarial Activity

J. Wiesner, H. Jomaa, A. Reichenberg, 2005, Archiv der Pharmazie.

Antimalarial Drugs – What is in Use and What is in the Pipeline

M. Schlitzer, 2008, Archiv der Pharmazie.

Development of Benzophenone‐Based Farnesyltransferase Inhibitors as Novel Antimalarials

Gerhard Klebe, Katrin Silber, Alexander Hillebrecht, 2008, ChemMedChem.

Non-thiol farnesyltransferase inhibitors: N-(4-aminoacylamino-3-benzoylphenyl)-3-[5-(4-nitrophenyl)-2 furyl]acrylic acid amides and their antimalarial activity.

G. Klebe, J. Wiesner, H. Jomaa, 2005, European journal of medicinal chemistry.

Non-thiol farnesyltransferase inhibitors: N-(4-tolylacetylamino-3-benzoylphenyl)-3-arylfurylacrylic acid amides.

G. Klebe, M. Schlitzer, I. Sattler, 2004, Bioorganic & medicinal chemistry.

Non-peptidic, non-prenylic bisubstrate farnesyltransferase inhibitors. Part 3: structural requirements of the central moiety for farnesyltransferase inhibitory activity.

M. Schlitzer, I. Sattler, M. Böhm, 2000, Bioorganic & medicinal chemistry.

Design, synthesis and early structure-activity relationship of farnesyltransferase inhibitors which mimic both the peptidic and the prenylic substrate.

M. Schlitzer, I. Sattler, H. Dahse, 2000, Bioorganic & medicinal chemistry.

From dithiocarbamates to branched dithiocarbazates: Compounds with potent antischistosomal activity

M. Schlitzer, C. Grevelding, A. Grünweller, 2022, Archiv der Pharmazie.

Benzophenone-based farnesyltransferase inhibitors with high activity against Trypanosoma cruzi.

G. Klebe, M. Schlitzer, E. Bontempi, 2005, Journal of medicinal chemistry.

Drug Discovery and Development for Schistosomiasis

K. Becker, M. Schlitzer, D. Drewry, 2019, Neglected Tropical Diseases.

Novel N-Phenyl–Substituted Thiazolidinediones Protect Neural Cells against Glutamate- and tBid-Induced Toxicity

C. Culmsee, M. Schlitzer, A. Dolga, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Identification and characterisation of the tegument-expressed aldehyde dehydrogenase SmALDH_312 of Schistosoma mansoni, a target of disulfiram.

D. Salzig, P. Czermak, S. Rahlfs, 2023, European journal of medicinal chemistry.

Structure-activity relationships of novel anti-malarial agents. Part 2: cinnamic acid derivatives.

J. Wiesner, H. Jomaa, M. Schlitzer, 2001, Bioorganic & medicinal chemistry letters.

Farnesyltransferase inhibitors inhibit the growth of malaria parasites in vitro and in vivo.

G. Klebe, J. Wiesner, H. Jomaa, 2004, Angewandte Chemie.

Antimalarial Drugs – What is in Use and What is in the Pipeline

M. Schlitzer, 2008, Archiv der Pharmazie.

Double Ester Prodrugs of FR900098 Display Enhanced In‐Vitro Antimalarial Activity

J. Wiesner, H. Jomaa, M. Schlitzer, 2007, Archiv der Pharmazie.

2-Acylamino-5-chlorobenzophenones with enhanced selectivity towards malaria parasites.

S. Heinrich, M. Schlitzer, M. Lanzer, 2011, European journal of medicinal chemistry.

Antimalarial and antitrypanosomal activity of a series of amide and sulfonamide derivatives of a 2,5-diaminobenzophenone.

S. Heinrich, M. Schlitzer, P. Chiba, 2009, Bioorganic & medicinal chemistry.

Malaria Chemotherapeutics Part I: History of Antimalarial Drug Development, Currently Used Therapeutics, and Drugs in Clinical Development

M. Schlitzer, Martin Schlitzer, 2007, ChemMedChem.

IMPROVED SYNTHESIS OF 2-SUBSTITUTED 4-CHLOROTHIAZOLE-5-CARBALDEHYDES

M. Schlitzer, W. Hanefeld, N. Debski, 1997 .

Improved Synthesis of 2-Substituted 4-Chlorothiazole-5-carbaldehydes.

M. Schlitzer, W. Hanefeld, N. Debski, 1998 .

Iminium carbonic acid derivative salts. IX. Synthesis of N,S‐containing heterobicycles from N‐protected 2‐methylthio‐1,3‐thiazinium and 2‐methylthiothiazolium salts part 1. Preparation of N‐protected 2‐methylthio‐1,3‐thiazinium and 2‐methylthiothiazolium salts and their reaction with CH‐acidic compo

M. Schlitzer, W. Hanefeld, M. Naeeni, 1996 .

Non‐Thiol Farnesyltransferase Inhibitors: Structure‐Activity Relationships of Aralkylsubsituted Benzophenones

M. Schlitzer, I. Sattler, A. Mitsch, 2001, Archiv der Pharmazie.

Synthesis of β- and γ-oxa isosteres of fosmidomycin and FR900098 as antimalarial candidates

J. Wiesner, H. Jomaa, M. Schlitzer, 2008 .

Synthesis of beta- and gamma-oxa isosteres of fosmidomycin and FR900098 as antimalarial candidates.

J. Wiesner, H. Jomaa, M. Schlitzer, 2008, Bioorganic & medicinal chemistry.

Diaryl ester prodrugs of FR900098 with improved in vivo antimalarial activity.

J. Wiesner, H. Jomaa, A. Reichenberg, 2001, Bioorganic & medicinal chemistry letters.

Studies Addressing the Importance of Charge in the Binding of Fosmidomycin‐Like Molecules to Deoxyxylulosephosphate Reductoisomerase

G. Klebe, J. Wiesner, H. Jomaa, 2008, ChemMedChem.

Fosmidomycin as an Antimalarial Agent

J. Wiesner, H. Jomaa, A. Reichenberg, 2012 .

Non-thiol farnesyltransferase inhibitors: the concept of benzophenone-based bisubstrate analogue farnesyltransferase inhibitors.

M. Schlitzer, I. Sattler, 2000, European journal of medicinal chemistry.

Non-Thiol Farnesyltransferase Inhibitors: Structure—Activity Relationships of Aralkylsubstituted Benzophenones.

M. Schlitzer, I. Sattler, A. Mitsch, 2001 .

Different Amino Acid Replacements in CAAX‐Tetrapeptide Based Peptidomimetic Farnesyltransferase Inhibitors

M. Schlitzer, I. Sattler, H. Dahse, 1999, Archiv der Pharmazie.

FR-900098, an antimalarial development candidate that inhibits the non-mevalonate isoprenoid biosynthesis pathway, shows no evidence of acute toxicity and genotoxicity

J. Wiesner, H. Jomaa, A. Reichenberg, 2016, Virulence.

Structure‐Based Optimization of Aldose Reductase Inhibitors Originating from Virtual Screening

Gerhard Klebe, Matthias Zentgraf, G. Klebe, 2009, ChemMedChem.

3-(Thiazolidin-3-yl)rhodanines. A novel class of rhodanine derivatives

M. Schlitzer, W. Hanefeld, 1994 .

The antimalarial pipeline--an update.

M. Schlitzer, R. Ortmann, Florian C. Schrader, 2012, International journal of medical microbiology : IJMM.

[Drugs against malaria: What's in the pipeline? Little new in the fight against malaria].

M. Schlitzer, 2009, Pharmazie in unserer Zeit.

Telithromycin and Quinupristin-Dalfopristin Induce Delayed Death in Plasmodium falciparum

M. Schlitzer, G. Pradel, Diana Barthel, 2007, Antimicrobial Agents and Chemotherapy.

Characterization of Novel Diphenylamine Compounds as Ferroptosis Inhibitors

C. Culmsee, M. Schlitzer, L. Hinder, 2021, The Journal of Pharmacology and Experimental Therapeutics.

Inhibition of Farnesyltransferase as a Strategy for the Development of Novel Anti-Malarials

M. Schlitzer, 2005 .

Structure-activity relationships of novel anti-malarial agents. Part 7: N-(3-benzoyl-4-tolylacetylaminophenyl)-3-(5-aryl-2-furyl)acrylic acid amides with polar moieties.

J. Wiesner, H. Jomaa, M. Schlitzer, 2003, Bioorganic & medicinal chemistry letters.

Structure-activity relationships of novel anti-malarial agents: part 5. N-(4-acylamino-3-benzoylphenyl)-[5-(4-nitrophenyl)-2-furyl]acrylic acid amides.

J. Wiesner, H. Jomaa, M. Schlitzer, 2003, Bioorganic & medicinal chemistry letters.

Structure-activity relationships of novel anti-malarial agents. Part 4: N-(3-benzoyl-4-tolylacetylaminophenyl)-3-(5-aryl-2-furyl)acrylic acid amides.

J. Wiesner, H. Jomaa, M. Schlitzer, 2002, Bioorganic & medicinal chemistry letters.

Structure based design of benzophenone-based non-thiol farnesyltransferase inhibitors.

M. Schlitzer, 2002, Current pharmaceutical design.

Exploration of novel aryl binding sites of farnesyltransferase using molecular modeling and benzophenone-based farnesyltransferase inhibitors.

M. Schlitzer, I. Sattler, M. Böhm, 2001, Journal of medicinal chemistry.

Non-peptidic, non-prenylic inhibitors of the prenyl protein-specific protease Rce1.

P. Casey, A. Winter-Vann, M. Schlitzer, 2001, Bioorganic & medicinal chemistry letters.

Antibiotics in malaria therapy and their effect on the parasite apicoplast.

M. Schlitzer, G Pradel, G. Pradel, 2010, Current molecular medicine.

N‐Acyl Derivatives of 4‐Phenoxyaniline as Neuroprotective Agents

C. Culmsee, M. Schlitzer, S. Oppermann, 2014, ChemMedChem.

Novel Type II Fatty Acid Biosynthesis (FAS II) Inhibitors as Multistage Antimalarial Agents

G. Klebe, S. Prigge, M. Schlitzer, 2013, ChemMedChem.

An Inexpensive Procedure for Reductive Aminations Using Dimethylamineborane on Millimolar and Molar Scale

M. Schlitzer, R. Ortmann, 2009 .

3-(2,5-Dioxopyrrolidin-1-yl), 3-(2,6-Dioxopiperidin-1-yl), and 3-(1,3- Dioxoisoindolin-2-yl)rhodanines. A Novel Type of Rhodanine Derivatives.

M. Schlitzer, W. Hanefeld, N. Debski, 1997 .

Novel Deoxyxylulosephosphate‐Reductoisomerase Inhibitors: Fosmidomycin Derivatives with Spacious Acyl Residues

G. Klebe, J. Wiesner, H. Jomaa, 2007, Archiv der Pharmazie.

RNase P Inhibitors Identified as Aggregators

M. Schlitzer, R. Hartmann, T. Steinmetzer, 2021, Antimicrobial agents and chemotherapy.