C. Sergheraert

发表

Screening of Plasmodium falciparum iron superoxide dismutase inhibitors and accuracy of the SOD-assays.

E. Davioud‐Charvet, L. Soulère, P. Delplace, 2003, Bioorganic & medicinal chemistry.

Direct evidence of cytoplasmic delivery of PKC-alpha, -epsilon and -zeta pseudosubstrate lipopeptides: study of their implication in the induction of apoptosis.

C. Sergheraert, C. Auriault, H. Gras-masse, 1999, FEBS letters.

Mycobacterial heparin-binding hemagglutinin and laminin-binding protein share antigenic methyllysines that confer resistance to proteolysis

C. Locht, C. Sergheraert, H. Drobecq, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Antitrypanosomal activities and cytotoxicity of 5-nitro-2-furancarbohydrazides.

E. Davioud‐Charvet, C. Sergheraert, L. Maes, 2002, Bioorganic & medicinal chemistry letters.

Synthesis of 5,5'-dithiobis(2-nitrobenzamides) as alternative substrates for trypanothione reductase and thioredoxin reductase: a microtiter colorimetric assay for inhibitor screening.

K. Becker, E. Davioud‐Charvet, C. Sergheraert, 1999, Analytical biochemistry.

Synthesis of non reducible inhibitors for trypanothione reductase from Trypanosoma cruzi.

C. Sergheraert, M. Aumercier, A. Tromelin, 1993 .

A role for MAP kinase in regulating ectodomain shedding of APLP2 in corneal epithelial cells.

C. Sergheraert, E. Loing, D. Zoukhri, 2001, American journal of physiology. Cell physiology.

Synthetic hispidin, a PKC inhibitor, is more cytotoxic toward cancer cells than normal cells in vitro

C. Sergheraert, E. Hollande, L. Chavant, 1997, Cell Biology and Toxicology.

Design and synthesis of new leads for PKC bisubstrate inhibitors.

C. Sergheraert, E. Buisine, A. Tartar, 1994 .

Phorbol ester-stimulated exocytosis in lacrimal gland: PKC might not be the sole effector.

C. Sergheraert, D. Zoukhri, B. Rossignol, 1993, The American journal of physiology.

Glucose regulates LXRα subcellular localization and function in rat pancreatic β-cells

C. Sergheraert, F. Pattou, J. Fruchart, 2006, Cell Research.

Design of potent protein kinase inhibitors using the bisubstrate approach.

C. Sergheraert, A. Tartar, J. Gesquiere, 1991, Journal of medicinal chemistry.

Synthesis and biological evaluation of benzimidazole derivatives as potent AMP-activated protein kinase activators.

C. Sergheraert, F. Foufelle, D. Caignard, 2006, Bioorganic & medicinal chemistry.

New spermine and spermidine derivatives as potent inhibitors of Trypanosoma cruzi trypanothione reductase.

E. Davioud‐Charvet, C. Sergheraert, B. Bonnet, 1997, Bioorganic & medicinal chemistry.

2-Amino diphenylsulfides as inhibitors of trypanothione reductase: modification of the side chain.

C. Sergheraert, B. Bonnet, D. Horvath, 1996, Bioorganic & medicinal chemistry.

2-Amino diphenylsulfides as new inhibitors of trypanothione reductase.

C. Sergheraert, M. Aumercier, A. Tartar, 1995, International journal of antimicrobial agents.

Solid phase synthesis of trypanothione disulfide

C. Sergheraert, A. Tartar, L. Bourel, 1994 .

Protein kinase C isoforms differentially control lacrimal gland functions.

C. Sergheraert, D. Zoukhri, R. Hodges, 1998, Advances in experimental medicine and biology.

Evidence for an endocannabinoid system in the central nervous system of the leech Hirudo medicinalis.

C. Sergheraert, T. Bisogno, C. Breton, 2001, Brain research. Molecular brain research.

Chloroquine and chloroquinoline derivatives as models for the design of modulators of amyloid Peptide precursor metabolism.

A. Delacourte, L. Buée, C. Sergheraert, 2015, ACS chemical neuroscience.

Cholinergic-induced Ca2+ elevation in rat lacrimal gland acini is negatively modulated by PKCdelta and PKCepsilon.

C. Sergheraert, D. Zoukhri, R. Hodges, 2000, Investigative ophthalmology & visual science.

Antiplasmodial activity and cytotoxicity of bis-, tris-, and tetraquinolines with linear or cyclic amino linkers.

E. Davioud‐Charvet, C. Sergheraert, L. Maes, 2001, Journal of medicinal chemistry.

Lacrimal gland PKC isoforms are differentially involved in agonist-induced protein secretion.

A. Toker, C. Sergheraert, D. Zoukhri, 1997, The American journal of physiology.

The rat lacrimal gland expresses the alpha isoform of PKC. Further evidence for the PMA-activated and phospholipid-independent protein kinase activity.

C. Sergheraert, E. Chambaz, D. Zoukhri, 1992, Cellular signalling.

Potent and specific inhibitors of trypanothione reductase from Trypanosoma cruzi: bis(2-aminodiphenylsulfides) for fluorescent labeling studies.

C. Sergheraert, L. Maes, J. Dubremetz, 2001, Bioorganic & medicinal chemistry.

New potent inhibitors of trypanothione reductase from Trypanosoma cruzi in the 2-aminodiphenylsulfide series

E. Davioud‐Charvet, C. Sergheraert, D. Horvath, 1997 .

Characterization of boar sperm cytoskeletal cylicin II as an actin-binding protein.

C. Sergheraert, H. Drobecq, C. Lécuyer, 2003, Biochemical and biophysical research communications.

Synthesis and antimalarial evaluation of new N1-(7-chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine derivatives.

C. Sergheraert, P. Melnyk, P. Grellier, 2005, Bioorganic & medicinal chemistry letters.

Parallel synthesis of a library of 1,4-naphthoquinones and automated screening of potential inhibitors of trypanothione reductase from Trypanosoma cruzi.

E. Davioud‐Charvet, C. Sergheraert, B. Déprez, 2000, Bioorganic & medicinal chemistry letters.

Structure-activity relationships in 2-aminodiphenylsulfides against trypanothione reductase from Trypanosoma cruzi.

E. Davioud‐Charvet, C. Sergheraert, A. Berecibar, 1998, Bioorganic & medicinal chemistry letters.

Trypanosoma cruzi Prolyl Oligopeptidase Tc80 Is Involved in Nonphagocytic Mammalian Cell Invasion by Trypomastigotes*

E. Davioud‐Charvet, C. Sergheraert, H. Drobecq, 2001, The Journal of Biological Chemistry.

Solid phase synthesis of 5′ non radioactive multiple labelled oligodesoxyribonucleotides.

C. Sergheraert, C. Pierlot, 1992 .

Synthesis and in vitro and in vivo antimalarial activity of N1-(7-chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine derivatives.

C. Sergheraert, L. Maes, P. Grellier, 2003, Journal of medicinal chemistry.

"One-pot" synthesis and antimalarial activity of formamidine derivatives of 4-anilinoquinoline.

C. Sergheraert, L. Maes, P. Grellier, 2001, Chemical & pharmaceutical bulletin.

PYBROP: A CONVENIENT ACTIVATOR FOR THE SYNTHESIS OF FORMAMIDINES

C. Sergheraert, S. Delarue, 1999 .

Design, synthesis and in vitro antimalarial activity of an acylhydrazone library.

C. Sergheraert, P. Melnyk, P. Grellier, 2006, Bioorganic & medicinal chemistry letters.

Optimized synthesis of tetrahydroisoquinoline-hydantoins

C. Sergheraert, P. Melnyk, Julie Charton, 2004 .

Convenient synthesis of tetrahydroisoquinoline-hydantoins

C. Sergheraert, Julie Charton, S. Vendeville, 2001 .

Antimalarial, antitrypanosomal, and antileishmanial activities and cytotoxicity of bis(9-amino-6-chloro-2-methoxyacridines): influence of the linker.

E. Davioud‐Charvet, C. Sergheraert, L. Maes, 2000, Journal of medicinal chemistry.

Synthesis, antimalarial activity, and molecular modeling of new pyrrolo[1,2-a]quinoxalines, bispyrrolo[1,2-a]quinoxalines, bispyrido[3,2-e]pyrrolo[1,2-a]pyrazines, and bispyrrolo[1,2-a]thieno[3,2-e]pyrazines.

C. Sergheraert, J. Leger, C. Jarry, 2004, Journal of medicinal chemistry.

Conversion of sterically hindered diacylated 1,2-phenylenediamines into 2-substituted benzimidazoles.

C. Sergheraert, Julie Charton, Sophie Girault-Mizzi, 2005, Chemical & pharmaceutical bulletin.

Derives soufres du methylcymantrene

C. Sergheraert, P. Marcincal, E. Cuingnet, 1977 .

Design, synthesis and antimalarial activity of novel, quinoline-based, zinc metallo-aminopeptidase inhibitors.

C. Sergheraert, P. Grellier, R. Deprez-Poulain, 2003, Bioorganic & medicinal chemistry letters.

Synthesis and antimalarial activity of new analogues of amodiaquine.

Philippe Grellier, C. Sergheraert, L. Maes, 2008, European journal of medicinal chemistry.

Design, synthesis and antimalarial activity of a glyoxylylhydrazone library.

C. Sergheraert, O. Melnyk, P. Melnyk, 2004, Bioorganic & medicinal chemistry letters.

Synthesis and antimalarial evaluation of new 1,4-bis(3-aminopropyl)piperazine derivatives.

C. Sergheraert, P. Grellier, R. Deprez-Poulain, 2003, Bioorganic & medicinal chemistry letters.

Vasopressin trisulphide : Synthesis, NMR study and affinity studies with V1 and V2 subtypes receptors

C. Sergheraert, G. Lippens, A. Tartar, 1997 .

Incorporation of the tricarbonylchromium ligand in aqueous media on the side chain of aromatic amino-acids

C. Sergheraert, A. Tartar, J. Brunet, 1982 .

Synthesis and in vitro and in vivo antimalarial activity of new 4-anilinoquinolines.

C. Sergheraert, L. Maes, P. Grellier, 2001, Journal of medicinal chemistry.

Preparation du [2.1.2.1] paracyclophane

C. Sergheraert, P. Marcincal, E. Cuingnet, 1977 .

2- and 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: synthesis and correlation between redox cycling activities and in vitro cytotoxicity.

V. Yardley, S. Croft, E. Davioud‐Charvet, 2001, Journal of medicinal chemistry.

New metallocenic phenylalanine analogs

C. Sergheraert, A. Tartar, H. Gras, 1981 .

Synthesis and pharmacological evaluation of Tic-hydantoin derivatives as selective sigma1 ligands. Part 2.

C. Sergheraert, P. Melnyk, Julie Charton, 2005, Bioorganic & medicinal chemistry letters.

Biochemical properties and cellular localization of Plasmodium falciparum protein disulfide isomerase.

C. Sergheraert, P. Grellier, M. Moutiez, 2007, Biochimie.

Preparation of trisulfide derivatives of cystine and their formation as by-products during peptide synthesis

C. Sergheraert, A. Tartar, M. Moutiez, 1994 .

Tricarbonylchromium tryptophan derivatives and their use in peptide synthesis

C. Sergheraert, A. Tartar, 1982 .

Synthesis and anti-HIV evaluation of D4T and D4T 5'-monophosphate prodrugs.

C. Sergheraert, A. Tartar, M. Lemaitre, 1993, Journal of medicinal chemistry.

Inhibition of protein kinase C by retro-inverso pseudosubstrate analogues.

C. Sergheraert, A. Tartar, A. Ricouart, 1989, Biochemical and biophysical research communications.

Comparison of the inhibition of human and Trypanosoma cruzi prolyl endopeptidases.

E. Davioud‐Charvet, C. Sergheraert, P. Grellier, 2002, Bioorganic & medicinal chemistry.

Automated parallel synthesis of a tetrahydroisoquinolin-based library: potential prolyl endopeptidase inhibitors.

E. Davioud‐Charvet, C. Sergheraert, B. Déprez, 1999, Bioorganic & medicinal chemistry letters.

Expression of protein kinase C isoforms in various steroidogenic cell types

C. Sergheraert, E. Chambaz, M. Benahmed, 1991, Molecular and Cellular Endocrinology.

Different protein kinase C isozymes mediate lower esophageal sphincter tone and phasic contraction of esophageal circular smooth muscle.

C. Sergheraert, U. Sohn, K. Harnett, 1997, Molecular pharmacology.

Inhibition of protein kinases by bis-ATP mimics

C. Sergheraert, M. Houdin, 1992 .

Truncated beta‐amyloid peptide species in pre‐clinical Alzheimer's disease as new targets for the vaccination approach

A. Delacourte, J. David, A. Wattez, 2003, Journal of neurochemistry.

Comparative efficiency of simple lipopeptide constructs for in vivo induction of virus-specific CTL.

C. Sergheraert, J. Guillet, A. Tartar, 1996, Vaccine.

Cloning of Plasmodium falciparum protein disulfide isomerase homologue by affinity purification using the antiplasmodial inhibitor 1,4‐bis{3‐[N‐(cyclohexyl methyl)amino]propyl}piperazine 1

C. Sergheraert, H. Drobecq, P. Grellier, 2000, FEBS letters.

Characterization of aggregates of hepatitis C virus glycoproteins.

C. Sergheraert, J. Dubuisson, H. Drobecq, 1999, The Journal of general virology.

Trypanosoma cruzi: a 52-kDa protein sharing sequence homology with glutathione S-transferase is localized in parasite organelles morphologically resembling reservosomes.

C. Sergheraert, J. Dubremetz, A. Tartar, 1995, Experimental parasitology.

Purification and characterization of a trypanothione-glutathione thioltransferase from Trypanosoma cruzi.

C. Sergheraert, M. Aumercier, A. Tartar, 1995, Biochemical Journal.

Synthesis of polyamine derivatives for the preparation of affinity chromatography columns for the search of new Trypanosoma cruzi targets.

E. Davioud‐Charvet, C. Sergheraert, H. Drobecq, 1999, Bioorganic & medicinal chemistry letters.

Trypanosoma cruzi: immunolocalization of trypanothione reductase.

C. Sergheraert, M. Aumercier, J. Dubremetz, 1994, Experimental parasitology.

Reduction of a trisulfide derivative of glutathione by glutathione reductase.

C. Sergheraert, M. Aumercier, A. Tartar, 1994, Biochemical and biophysical research communications.

Compared recognition of di- and trisulfide substrates by glutathione and trypanothione reductases.

C. Sergheraert, M. Aumercier, A. Tartar, 1995, Biochimica et biophysica acta.

Glucose regulates LXRalpha subcellular localization and function in rat pancreatic beta-cells.

C. Sergheraert, F. Pattou, J. Fruchart, 2006, Cell Research.

Identification of vasoactive intestinal peptide receptor subtypes in the lacrimal gland and their signal-transducing components.

C. Sergheraert, J. Zieske, D. Zoukhri, 1997, Investigative ophthalmology & visual science.

Novel N-(4-Piperidinyl)benzamide antimalarials with mammalian protein farnesyltransferase inhibitory activity.

C. Sergheraert, A. Lemoine, N. Pommery, 2005, Chemical & pharmaceutical bulletin.

A general approach to the synthesis of polyamine linked-monoindolylmaleimides, a new series of trypanothione reductase inhibitors.

E. Davioud‐Charvet, C. Sergheraert, O. Melnyk, 1998, Chemical and pharmaceutical bulletin.

Methylation-dependent T cell immunity to Mycobacterium tuberculosis heparin-binding hemagglutinin

C. Locht, C. Sergheraert, F. Mascart, 2004, Nature Medicine.

A prodrug form of a Plasmodium falciparum glutathione reductase inhibitor conjugated with a 4-anilinoquinoline.

R. Schirmer, K. Becker, C. Biot, 2001, Journal of medicinal chemistry.

Photosubstitution of cymantrenylalanine as a tool in peptide chemistry. Synthesis and biological activity of new GnRH analogs.

C. Sergheraert, B. Kerdelhué, P. Maes, 2009, International journal of peptide and protein research.

Trypanothione reductase inhibition/trypanocidal activity relationships in a 1,4-bis(3-aminopropyl)piperazine series.

E. Davioud‐Charvet, C. Sergheraert, B. Bonnet, 2000, Bioorganic & medicinal chemistry.

Synthesis and antimalarial activity of carbamate and amide derivatives of 4-anilinoquinoline.

C. Sergheraert, L. Maes, P. Melnyk, 2008, European journal of medicinal chemistry.

Cholinergic-Induced Ca2+ Elevation in Rat Lacrimal Gland Acini Is Negatively Modulated by PKCδ and PKCε

C. Sergheraert, D. Zoukhri, R. Hodges, 2000 .

Synthesis and pharmacological evaluation of Tic-hydantoin derivatives as selective sigma1 ligands. Part 1.

C. Sergheraert, P. Melnyk, Julie Charton, 2005, Bioorganic & Medicinal Chemistry Letters.

Synthesis and antimalarial evaluation of new 1,4-bis(3-aminopropyl)piperazine derivatives.

C. Sergheraert, P. Grellier, R. Deprez-Poulain, 2003, Bioorganic & medicinal chemistry letters.

TETRAAROMATIC MACROCYCLES DERIVED FROM (2.1.2.1)PARACYCLOPHANE

C. Sergheraert, P. Marcincal, E. Cuingnet, 1979 .

Glutathione-dependent activities of Trypanosoma cruzi p52 makes it a new member of the thiol:disulphide oxidoreductase family.

E. Davioud‐Charvet, C. Sergheraert, A. Tartar, 1997, The Biochemical journal.

β-ferrocenylalanyl peptides : I. Synthesis of [Fer4, Leu5] enkephalin

C. Sergheraert, A. Tartar, M. Dautrevaux, 1980 .

Direct evidence of cytoplasmic delivery of PKC‐α, ‐ϵ and ‐ζ pseudosubstrate lipopeptides: study of their implication in the induction of apoptosis

C. Sergheraert, C. Auriault, H. Gras-masse, 1999 .