B. Snedecor

发表

Application of dynamic flux balance analysis to an industrial Escherichia coli fermentation.

Adam L. Meadows, R. Karnik, H. Lam, 2010, Metabolic engineering.

Slashing the timelines: Opting to generate high‐titer clonal lines faster via viability‐based single cell sorting

B. Snedecor, David Shaw, S. Misaghi, 2016, Biotechnology progress.

High Level Escherichia coli Expression and Production of a Bivalent Humanized Antibody Fragment

Brad Snedecor, B. Snedecor, P. Carter, 1992, Bio/Technology.

High‐level accumulation of a recombinant antibody fragment in the periplasm of Escherichia coli requires a triple‐mutant (degP prc spr) host strain

John C Joly, Brad Snedecor, B. Snedecor, 2004, Biotechnology and bioengineering.

Thermophilic mixed culture of bacteria utilizing methanol for growth.

B. Snedecor, C. Cooney, 1974, Applied microbiology.

Decreasing lactate level and increasing antibody production in Chinese Hamster Ovary cells (CHO) by reducing the expression of lactate dehydrogenase and pyruvate dehydrogenase kinases.

N. Vijayasankaran, B. Snedecor, J. Joly, 2011, Journal of biotechnology.

Maximizing Antibody Production in a Targeted Integration Host by Optimization of Subunit Gene Dosage and Position.

B. Snedecor, David Shaw, Michael W. Laird, 2020, Biotechnology progress.

Fast identification of reliable hosts for targeted cell line development from a limited‐genome screening using combined φC31 integrase and CRE‐Lox technologies

B. Snedecor, J. Joly, Zhilan Hu, 2013, Biotechnology progress.

Controlling glycation of recombinant antibody in fed‐batch cell cultures

N. Vijayasankaran, B. Snedecor, J. Joly, 2011, Biotechnology and bioengineering.

Evaluation of heavy chain C‐terminal deletions on productivity and product quality of monoclonal antibodies in Chinese hamster ovary (CHO) cells

B. Snedecor, Michael W. Laird, S. Misaghi, 2017, Biotechnology progress.

Methode de production d'anticorps presentant une fonction amelioree

B. Snedecor, Domingos Ng, Amy Shen, 2006 .

Insulin Degrading Enzyme (IDE) Expressed by Chinese Hamster Ovary (CHO) Cells Is Responsible for Degradation of Insulin in Culture Media.

B. Snedecor, S. Misaghi, S. Louie, 2020, Journal of biotechnology.

Endothelial intercellular cell adhesion molecule 1 contributes to cell aggregate formation in CHO cells cultured in serum‐free media

B. Snedecor, W. Sandoval, David Shaw, 2019, Biotechnology progress.

Probing the importance of clonality: Single cell subcloning of clonally derived CHO cell lines yields widely diverse clones differing in growth, productivity, and product quality

B. Snedecor, David Shaw, Michael W. Laird, 2018, Biotechnology progress.

A strategy to accelerate protein production from a pool of clones in Chinese hamster ovary cells for toxicology studies

B. Snedecor, Michael W. Laird, J. Joly, 2017, Biotechnology progress.

UBR E3 ligases and the PDIA3 protease control degradation of unfolded antibody heavy chain by ERAD

B. Snedecor, Deepankar Roy, Peter S Liu, 2020, The Journal of cell biology.

High Intracellular Seed Train BiP Levels Correlate With Poor Production Culture Performance in CHO Cells.

B. Snedecor, S. Misaghi, Szu-Han Wang, 2018, Biotechnology journal.

Engineered Cytochrome P450-Catalyzed Oxidative Biaryl Coupling Reaction Provides a Scalable Entry into Arylomycin Antibiotics.

B. Snedecor, F. Gosselin, Y. Kawasaki, 2022, Journal of the American Chemical Society.

Development and characterization of an automated imaging workflow to generate clonally‐derived cell lines for therapeutic proteins

Andy Lin, Mandy Yim, Joni Tsukuda, 2018, Biotechnology progress.

Growth inhibition of Clostridium thermocellum by carboxylic acids: A mechanism based on uncoupling by weak acids

B. Snedecor, M. Roberts, A. Herrero, 1985, Applied Microbiology and Biotechnology.

Antigen binding thermodynamics and antiproliferative effects of chimeric and humanized anti-p185HER2 antibody Fab fragments.

L. Presta, B. Snedecor, P. Carter, 1992, Biochemistry.

High Level Secretion of a Humanized Bispecific Diabody from Escherichia coli

B. Snedecor, P. Carter, Zhen-ping Zhu, 1996, Bio/Technology.

Supplementation of Nucleosides During Selection can Reduce Sequence Variant Levels in CHO Cells Using GS/MSX Selection System

B. Snedecor, K. H. Hoi, David Shaw, 2018, Biotechnology journal.

Mechanisms of unintended amino acid sequence changes in recombinant monoclonal antibodies expressed in Chinese Hamster Ovary (CHO) cells

B. Snedecor, Michael W. Laird, J. Joly, 2010, Biotechnology and bioengineering.

Development of a targeted integration Chinese hamster ovary host directly targeting either one or two vectors simultaneously to a single locus using the Cre/Lox recombinase‐mediated cassette exchange system

B. Snedecor, Z. Modrušan, Michael W. Laird, 2021, Biotechnology progress.

Beating the odds: The poisson distribution of all input cells during limiting dilution grossly underestimates whether a cell line is clonally‐derived or not

Y. Zhou, B. Snedecor, David Shaw, 2018, Biotechnology progress.

Carboxypeptidase D is the only enzyme responsible for antibody C‐terminal lysine cleavage in Chinese hamster ovary (CHO) cells

B. Snedecor, J. Joly, S. Misaghi, 2016, Biotechnology and bioengineering.

Réduction du niveau de lactate et augmentation de la production de polypeptides par régulation négative de l'expression de la lactate déshydrogénase et de la pyruvate déshydrogénase kinase

B. Snedecor, Meixia Zhou, Amy Shen, 2011 .

Concurrent transfection of randomized transgene configurations into targeted integration CHO host is an advantageous and cost‐effective method for expression of complex molecules

B. Snedecor, S. Misaghi, S. Louie, 2020, Biotechnology journal.

Utilizing a regulated targeted integration cell line development approach to systematically investigate what makes an antibody difficult to express

Y. Zhou, B. Snedecor, S. Misaghi, 2019, Biotechnology progress.

Taming hyperactive hDNase I: Stable inducible expression of a hyperactive salt‐ and actin‐resistant variant of human deoxyribonuclease I in CHO cells

B. Snedecor, S. Misaghi, S. Louie, 2017, Biotechnology progress.

It's time to regulate: Coping with product‐induced nongenetic clonal instability in CHO cell lines via regulated protein expression

B. Snedecor, S. Misaghi, Jennifer C. Chang, 2014, Biotechnology progress.

Preventing pyruvate kinase muscle expression in Chinese hamster ovary cells curbs lactogenic behavior by altering glycolysis, gating pyruvate generation, and increasing pyruvate flux into the TCA cycle

B. Snedecor, W. Sandoval, S. Misaghi, 2021, Biotechnology progress.

FX knockout CHO hosts can express desired ratios of fucosylated or afucosylated antibodies with high titers and comparable product quality

B. Snedecor, David Shaw, S. Misaghi, 2017, Biotechnology and bioengineering.

Expressing antigen binding fragments with high titers in a targeted integration CHO host by optimizing expression vector gene copy numbers and position: A case study

B. Snedecor, S. Misaghi, Amy Shen, 2022, Biotechnology progress.

Adapting pharmacokinetic properties of a humanized anti-interleukin-8 antibody for therapeutic applications using site-specific pegylation.

L. Presta, B. Snedecor, Z. Shahrokh, 2001, Cytokine.

Chinese hamster ovary K1 host cell enables stable cell line development for antibody molecules which are difficult to express in DUXB11‐derived dihydrofolate reductase deficient host cell

B. Snedecor, J. Joly, S. Misaghi, 2013, Biotechnology progress.

Resilient immortals, characterizing and utilizing Bax/Bak deficient Chinese hamster ovary (CHO) cells for high titer antibody production

B. Snedecor, S. Misaghi, A. Snowden, 2013, Biotechnology progress.

Selection, expression, and nucleotide sequencing of the glutamate dehydrogenase gene of Peptostreptococcus asaccharolyticus

B. Snedecor, E. Chen, H. Chu, 1991, Journal of bacteriology.

Complete Knockout of the Lactate Dehydrogenase A Gene is Lethal in Pyruvate Dehydrogenase Kinase 1, 2, 3 Down-Regulated CHO Cells

B. Snedecor, J. Joly, Meixia Zhou, 2014, Molecular Biotechnology.

Characterization of Humanized Anti-p185HER2Antibody Fab Fragments Produced inEscherichia coli

L. Presta, B. Snedecor, P. Carter, 1993 .

Activation of the PERK branch of the unfolded protein response during production reduces specific productivity in CHO cells via downregulation of PDGFRa and IRE1a signaling.

B. Snedecor, W. Sandoval, S. Misaghi, 2023, Biotechnology progress.

Metabolic oscillations in an E. coli fermentation.

B. Snedecor, T. Ryll, J. Swartz, 2001, Biotechnology and bioengineering.

Pyruvate Kinase Muscle-1 Expression Appears to Drive Lactogenic Behavior in CHO Cell Lines, Triggering Lower Viability and Productivity: A Case Study.

B. Snedecor, W. Sandoval, Michael W. Laird, 2018, Biotechnology journal.

Fast identification of reliable hosts for targeted cell line development from a limited‐genome screening using combined φC31 integrase and CRE‐Lox technologies

B. Snedecor, J. Joly, Zhilan Hu, 2013, Biotechnology progress.

Engineering Fab' fragments for efficient F(ab)2 formation in Escherichia coli and for improved in vivo stability.

B. Snedecor, P. Carter, W. L. Wong, 1993, Journal of immunology.