D. Kyle

发表

Evidence for the shikimate pathway in apicomplexan parasites

D. Chakrabarti, F. Roberts, C. Roberts, 1998, Nature.

Epigenetic Tailoring for the Production of Anti-Infective Cytosporones from the Marine Fungus Leucostoma persoonii

D. Kyle, L. Shaw, B. Baker, 2012, Marine drugs.

Current treatment and drug discovery against Leishmania spp. and Plasmodium spp.: a review.

D. Kyle, A. Cruz, J. S. de Toledo, 2009, Current drug targets.

Discovery of Anti-Amoebic Inhibitors from Screening the MMV Pandemic Response Box on Balamuthia mandrillaris, Naegleria fowleri, and Acanthamoeba castellanii

D. Kyle, C. Rice, E. Troth, 2020, Pathogens.

Development and validation of flow cytometric measurement for parasitemia in cultures of P. falciparum vitally stained with YOYO‐1

Jing Zhang, Lisa Xie, Wilbur Milhous, 2007, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

Development and validation of flow cytometric measurement for parasitaemia using autofluorescence and YOYO-1 in rodent malaria

D. Kyle, W. Milhous, Qigui Li, 2007, Parasitology.

Convenient Access Both to Highly Antimalaria‐Active 10‐Arylaminoartemisinins, and to 10‐Alkyl Ethers Including Artemether, Arteether, and Artelinate

L. Gerena, D. Kyle, H. Chan, 2005, Chembiochem : a European journal of chemical biology.

Comparative bioavailability of oral, rectal, and intramuscular artemether in healthy subjects: use of simultaneous measurement by high performance liquid chromatography and bioassay.

D. Kyle, F. T. Ter Kuile, N. White, 1996, British journal of clinical pharmacology.

World Antimalarial Resistance Network (WARN) II: In vitro antimalarial drug susceptibility

Carol Hopkins Sibley, D. Kyle, J. Le bras, 2007, Malaria Journal.

Malaria: progress, perils, and prospects for eradication.

S. Kappe, D. Kyle, D. Fidock, 2008, The Journal of clinical investigation.

Microphysical space of a liver sinusoid device enables simplified long-term maintenance of chimeric mouse-expanded human hepatocytes

D. Kyle, W. Saadi, J. Cuiffi, 2014, Biomedical microdevices.

The transcriptome of Balamuthia mandrillaris trophozoites for structure-based drug design

P. Myler, D. Kyle, I. Phan, 2020, bioRxiv.

Regulation of leukocyte adhesion molecules CD11b/CD18 and leukocyte adhesion molecule-1 on phagocytic cells activated by malaria pigment.

H. Webster, D. Kyle, S. Pichyangkul, 1997, The American journal of tropical medicine and hygiene.

Poor efficacy of antimalarial biguanide-dapsone combinations in the treatment of acute, uncomplicated, falciparum malaria in Thailand.

D. Kyle, N. White, S. Looareesuwan, 1997, Annals of Tropical Medicine and Parasitology.

Effects of Artesunate on Parasite Recrudescence and Dormancy in the Rodent Malaria Model Plasmodium vinckei

Dennis E. Kyle, D. Kyle, Katherine Kennedy, 2011, PloS one.

4(1H)-Quinolones with Liver Stage Activity against Plasmodium berghei

D. Kyle, Tina S. Mutka, Roman Manetsch, 2012, Antimicrobial Agents and Chemotherapy.

Pharmacokinetics and pharmacodynamics of qinghaosu derivatives: how do they impact on the choice of drug and the dosage regimens?

D. Kyle, P. Teja-Isavadharm, Q. Li, 1998, Medecine tropicale : revue du Corps de sante colonial.

Artemisinin-induced parasite dormancy: a plausible mechanism for treatment failure

M. Gatton, Q. Cheng, D. Kyle, 2011, Malaria Journal.

Plasmodium falciparum: the effects of atovaquone resistance on respiration.

D. Kyle, N. Lang-Unnasch, E. Suswam, 2001, Experimental parasitology.

Confirmation of emergence of mutations associated with atovaquone-proguanil resistance in unexposed Plasmodium falciparum isolates from Africa

O. Sarr, D. Wirth, D. Kyle, 2006, Malaria Journal.

Ultrastructural study of the effects of chloroquine and verapamil on Plasmodium falciparum.

D. Kyle, W. Milhous, M. Aikawa, 1988, The American journal of tropical medicine and hygiene.

Leishmania spp.: development of pentostam-resistant clones in vitro by discontinuous drug exposure.

D. Kyle, A. Oduola, M. Grögl, 1989, Experimental parasitology.

New Class of Small Nonpeptidyl Compounds BlocksPlasmodium falciparum Development In Vitro by Inhibiting Plasmepsins

Dennis E. Kyle, John B. Dame, J. Dame, 2001, Antimicrobial Agents and Chemotherapy.

against Plasmodium berghei )-Quinolones with Liver Stage Activity H

D. Kyle, S. Mutka, Roman Manetsch, 2013 .

A novel multiple-stage antimalarial agent that inhibits protein synthesis

David W. Gray, E. Winzeler, S. Meister, 2015, Nature.

Cardiac effects of antimalarial treatment with halofantrine

D. Kyle, N. White, C. Woodrow, 1993, The Lancet.

Exploitation of Mangrove Endophytic Fungi for Infectious Disease Drug Discovery

D. Kyle, L. Shaw, B. Baker, 2018, Marine drugs.

Neurotoxicity and efficacy of arteether related to its exposure times and exposure levels in rodents.

D. Kyle, W. Milhous, Qigui Li, 2002, The American journal of tropical medicine and hygiene.

Dragonamide E, a modified linear lipopeptide from Lyngbya majuscula with antileishmanial activity.

Roger G. Linington, Marcy J. Balunas, D. Kyle, 2010, Journal of natural products.

Modelstant Malaria in a Rodent Effective Partner Drug for Treatment of Evidence for Pyronaridine as a Highly

D. Kyle, D. Fidock, Connor O'brien, 2014 .

Evidence for Pyronaridine as a Highly Effective Partner Drug for Treatment of Artemisinin-Resistant Malaria in a Rodent Model

S. Cremers, D. Kyle, D. Fidock, 2013, Antimicrobial Agents and Chemotherapy.

Endochin optimization: structure-activity and structure-property relationship studies of 3-substituted 2-methyl-4(1H)-quinolones with antimalarial activity.

D. Kyle, Tina S. Mutka, J. Burrows, 2010, Journal of medicinal chemistry.

Synthesis and antimalarial activity of sixteen dispiro-1,2,4, 5-tetraoxanes: alkyl-substituted 7,8,15,16-tetraoxadispiro[5.2.5. 2]hexadecanes.

J. K. Wood, S. M. Walters, James K. Wood, 2000, Journal of medicinal chemistry.

Orally Bioavailable 6-Chloro-7-methoxy-4(1H)-quinolones Efficacious against Multiple Stages of Plasmodium

David M. Shackleford, W. Guida, D. Kyle, 2014, Journal of medicinal chemistry.

Structure-activity and structure-property relationship studies of spirocyclic chromanes with antimalarial activity.

D. Chakrabarti, D. Kyle, L. Wojtas, 2022, Bioorganic & medicinal chemistry.

Synthesis and antimalarial activity of new isotebuquine analogues.

L. Gerena, D. Kyle, O. Miroshnikova, 2007, Journal of medicinal chemistry.

Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond Citation

Alessandro, Serge, Tyler B. Hughes, 2016 .

An adaptable soft-mold embossing process for fabricating optically-accessible, microfeature-based culture systems and application toward liver stage antimalarial compound testing.

D. Kyle, C. Andolina, Brice Campo, 2020, Lab on a chip.

Alkyne modified purines for assessment of activation of Plasmodium vivax hypnozoites and growth of pre-erythrocytic and erythrocytic stages in Plasmodium spp.

M. Cassera, E. F. Merino, D. Kyle, 2022, International journal for parasitology.

Single-cell RNA profiling of Plasmodium vivax-infected hepatocytes reveals parasite- and host- specific transcriptomic signatures and therapeutic targets

D. Kyle, I. Mueller, A. Jex, 2022, bioRxiv.

Phenotypic Changes in Artemisinin-Resistant Plasmodium falciparum Lines In Vitro: Evidence for Decreased Sensitivity to Dormancy and Growth Inhibition

M. Gatton, Q. Cheng, D. Kyle, 2011, Antimicrobial Agents and Chemotherapy.

evidence for decreased sensitivity to dormancy and growth inhibition 2

M. Gatton, Q. Cheng, D. Kyle, 2011 .

Antimalarial drugs reduce cytoadherence and rosetting Plasmodium falciparum.

D. Kyle, B. Angus, R. Udomsangpetch, 1996, Journal of Infectious Diseases.

Screening Mangrove Endophytic Fungi for Antimalarial Natural Products

D. Kyle, K. Pang, C. Pearce, 2013, Marine drugs.

Polychlorinated cyclopentenes from a marine derived Periconia sp. (strain G1144).

D. Kyle, H. Raja, N. Oberlies, 2022, Phytochemistry.

Protozoan persister-like cells and drug treatment failure

L. Sibley, M. Barrett, D. Kyle, 2019, Nature Reviews Microbiology.

Point mutations in the pfcrt and pfmdr-1 genes of Plasmodium falciparum and clinical response to chloroquine, among malaria patients from Nigeria

L. Gerena, D. Wirth, D. Kyle, 2003, Annals of tropical medicine and parasitology.

In vitro sensitivity of Plasmodium falciparum to artesunate in Thailand.

D. Kyle, C. Wongsrichanalai, W. Wernsdorfer, 1999, Bulletin of the World Health Organization.

Cover Picture: Artemisone—A Highly Active Antimalarial Drug of the Artemisinin Class (Angew. Chem. Int. Ed. 13/2006)

S. Croft, K. Rieckmann, D. Kyle, 2006 .

Titelbild: Artemisone—A Highly Active Antimalarial Drug of the Artemisinin Class (Angew. Chem. 13/2006)

S. Croft, K. Rieckmann, D. Kyle, 2006 .

Streamlining sporozoite isolation from mosquitoes by leveraging the dynamics of migration to the salivary glands

D. Kyle, C. Murdock, B. Franke-Fayard, 2022, Malaria Journal.

Plasmodium falciparum and Plasmodium vivax Demonstrate Contrasting Chloroquine Resistance Reversal Phenotypes

R. Price, Q. Cheng, E. Kenangalem, 2017, Antimicrobial Agents and Chemotherapy.

Coibacins A-D, antileishmanial marine cyanobacterial polyketides with intriguing biosynthetic origins.

Marcy J. Balunas, D. Kyle, W. Gerwick, 2012, Organic letters.

Probing the distinct chemosensitivity of Plasmodium vivax liver stage parasites and demonstration of 8-aminoquinoline radical cure activity in vitro

D. Kyle, C. Andolina, F. Nosten, 2021, Scientific Reports.

4(1H)-pyridone and 4(1H)-quinolone derivatives as antimalarials with erythrocytic, exoerythrocytic, and transmission blocking activities.

D. Kyle, Roman Manetsch, Andrii Monastyrskyi, 2014, Current topics in medicinal chemistry.

Clinical trial of halofantrine with modified doses for treatment of malaria in the hospital for tropical diseases.

D. Kyle, S. Krudsood, P. Singhasivanon, 2001, The Southeast Asian journal of tropical medicine and public health.

Optimal 10-Aminoartemisinins With Potent Transmission-Blocking Capabilities for New Artemisinin Combination Therapies–Activities Against Blood Stage P. falciparum Including PfKI3 C580Y Mutants and Liver Stage P. berghei Parasites

E. Winzeler, D. Kyle, W. Liebenberg, 2020, Frontiers in Chemistry.

Discovery of repurposing drug candidates for the treatment of diseases caused by pathogenic free-living amoebae

D. Kyle, M. Hull, C. Rice, 2020, bioRxiv.

Bastimolide A, a Potent Antimalarial Polyhydroxy Macrolide from the Marine Cyanobacterium Okeania hirsuta.

Roger G. Linington, Paul D. Boudreau, Marcy J. Balunas, 2015, The Journal of organic chemistry.

Blood flukes Cardicola parvus and C. laruei (Trematoda: Aporocotylidae): life cycles and cryptic infection in spotted seatrout, Cynoscion nebulosus (Teleost: Sciaenidae).

D. Kyle, Sasha V. Siegel, J. Oberstaller, 2018, Parasitology international.

Response of Soybean Accessions from Provinces in Southern China to Phytophthora sojae.

C. D. Nickell, D. Kyle, R. Nelson, 1998, Plant disease.

Clinical features cannot predict a diagnosis of malaria or differentiate the infecting species in children living in an area of low transmission.

D. Kyle, N. White, F. Nosten, 1998, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Linkage disequilibrium between two distinct loci in chromosomes 5 and 7 of Plasmodium falciparum and in vivo chloroquine resistance in Southwest Nigeria

D. Wirth, D. Kyle, W. Milhous, 2006, Parasitology Research.

Conservation of Ancient Genetic Pathways for Intracellular Persistence Among Animal Pathogenic Bordetellae

D. Kyle, B. Linz, E. Harvill, 2019, Front. Microbiol..

Microphysical space of a liver sinusoid device enables simplified long-term maintenance of chimeric mouse-expanded human hepatocytes

D. Kyle, W. Saadi, J. Cuiffi, 2014, Biomedical microdevices.

Antileishmanial Activity of a Series of N2,N4-Disubstituted Quinazoline-2,4-diamines

D. Kyle, S. Rijal, M. Vanaerschot, 2014, Journal of medicinal chemistry.

Optimization of 1,2,3,4-tetrahydroacridin-9(10H)-ones as antimalarials utilizing structure-activity and structure-property relationships.

D. Kyle, Tina S. Mutka, Roman Manetsch, 2011, Journal of medicinal chemistry.

Antimalarial activity and interactions between quinine, dihydroquinine and 3-hydroxyquinine against Plasmodium falciparum in vitro.

D. Kyle, S. Pukrittayakamee, N. White, 1996, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Efficacy of quinine-tetracycline for acute uncomplicated falciparum malaria in Thailand

D. Kyle, S. Looareesuwan, P. Wilairatana, 1992, The Lancet.

In vitro strategies for circumventing antimalarial drug resistance.

L. Gerena, D. Kyle, W. Milhous, 1989, Progress in clinical and biological research.

The Presence of Leukocytes in Ex Vivo Assays Significantly Increases the 50-Percent Inhibitory Concentrations of Artesunate and Chloroquine against Plasmodium vivax and Plasmodium falciparum

D. Kyle, L. Rénia, F. Nosten, 2010, Antimicrobial Agents and Chemotherapy.

Pharmacokinetics of oral artesunate in children with moderately severe Plasmodium falciparum malaria.

D. Kyle, N. Day, N. White, 1997, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Keikipukalides, Furanocembrane Diterpenes from the Antarctic Deep Sea Octocoral Plumarella delicatissima

D. Kyle, B. Baker, C. Rice, 2017, Journal of natural products.

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

Manuel Llinás, George Papadatos, Sundari Suresh, 2016, PLoS pathogens.

Differential Growth Rates and In Vitro Drug Susceptibility to Currently Used Drugs for Multiple Isolates of Naegleria fowleri

D. Kyle, A. C. Russell, 2021, bioRxiv.

EdU Incorporation To Assess Cell Proliferation and Drug Susceptibility in Naegleria fowleri

D. Kyle, E. Troth, 2021, Antimicrobial agents and chemotherapy.

EdU incorporation to assess cell proliferation and drug susceptibility for the brain-eating amoeba, Naegleria fowleri

D. Kyle, E. Troth, 2021, bioRxiv.

Running Head: Growth Rates and Drug Susceptibility of N. fowleri

D. Kyle, A. C. Russell, 2021 .

In Vitro Screening of the Open-Source Medicines for Malaria Venture Malaria and Pathogen Boxes To Discover Novel Compounds with Activity against Balamuthia mandrillaris

D. Kyle, C. Rice, F. Lares-Villa, 2020, Antimicrobial Agents and Chemotherapy.

Phenotypic Screens Reveal Posaconazole as a Rapidly Acting Amebicidal Combination Partner for Treatment of Primary Amoebic Meningoencephalitis

D. Kyle, R. Guy, C. Rice, 2018, The Journal of infectious diseases.

Oxindole-based compounds are selective inhibitors of Plasmodium falciparum cyclin dependent protein kinases.

Apurba K Bhattacharjee, S. Prigge, L. Gerena, 2003, Journal of medicinal chemistry.

Novel 4-Aminoquinoline Analogs Highly Active against the Blood and Sexual Stages of Plasmodium In Vivo and In Vitro

D. Kyle, A. Oduola, F. E. Sáenz, 2012, Antimicrobial Agents and Chemotherapy.

Bis-Benzimidazole Hits against Naegleria fowleri Discovered with New High-Throughput Screens

D. Kyle, D. Boykin, C. Rice, 2015, Antimicrobial Agents and Chemotherapy.

Metabolic, Pharmacokinetic, and Activity Profile of the Liver Stage Antimalarial (RC-12)

D. Kyle, S. Charman, C. Kocken, 2022, ACS omega.

Lead optimization of 3-carboxyl-4(1H)-quinolones to deliver orally bioavailable antimalarials.

D. Kyle, M. Phillips, J. Gow, 2012, Journal of medicinal chemistry.

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

Juan A. Bueren-Calabuig, Andrei V. Pisliakov, David W. Gray, 2019, Proceedings of the National Academy of Sciences.

Leishmanicidal activity of a daucane sesquiterpene isolated from Eryngium foetidum

D. Kyle, I. Raskin, A. Poulev, 2014, Pharmaceutical biology.

Spirocyclic chromanes exhibit antiplasmodial activities and inhibit all intraerythrocytic life cycle stages

D. Chakrabarti, D. Kyle, L. Ayong, 2016, International journal for parasitology. Drugs and drug resistance.

Spongian Diterpenoids Derived from the Antarctic Sponge Dendrilla antarctica Are Potent Inhibitors of the Leishmania Parasite.

D. Kyle, C. Amsler, B. Baker, 2020, Journal of natural products.

Clinical study of pyronaridine for the treatment of acute uncomplicated falciparum malaria in Thailand.

D. Kyle, W. Wernsdorfer, S. Looareesuwan, 1996, The American journal of tropical medicine and hygiene.

Clinical studies of atovaquone, alone or in combination with other antimalarial drugs, for treatment of acute uncomplicated malaria in Thailand.

H. Webster, D. Kyle, S. Looareesuwan, 1996, The American journal of tropical medicine and hygiene.

Cholic acid derivatives as 1,2,4,5-tetraoxane carriers: structure and antimalarial and antiproliferative activity.

D. Kyle, W. Milhous, B. Tinant, 2000, Journal of medicinal chemistry.

Synthesis, antimalarial activity, and structure-activity relationship of 7-(2-phenoxyethoxy)-4(1H)-quinolones.

D. Kyle, Roman Manetsch, R. M. Cross, 2011, Journal of medicinal chemistry.

Synthesis, characterization, and cellular localization of a fluorescent probe of the antimalarial 8-aminoquinoline primaquine.

D. Kyle, M. Kemp, R. Larsen, 2017, Bioorganic & medicinal chemistry letters.

Structure-activity relationships of analogs of pentamidine against Plasmodium falciparum and Leishmania mexicana amazonensis

D. Kyle, M. Grogl, J. Hall, 1990, Antimicrobial Agents and Chemotherapy.

Antimalarial peptides from marine cyanobacteria: isolation and structural elucidation of gallinamide A.

Roger G. Linington, D. Kyle, W. Gerwick, 2009, Journal of natural products.

Artemisone--a highly active antimalarial drug of the artemisinin class.

S. Croft, K. Rieckmann, D. Kyle, 2006, Angewandte Chemie.

Comparative pharmacokinetics and effect kinetics of orally administered artesunate in healthy volunteers and patients with uncomplicated falciparum malaria.

D. Kyle, T. Brewer, N. Sirisopana, 2001, The American journal of tropical medicine and hygiene.

Plasmodium falciparum: modulation by calcium antagonists of resistance to chloroquine, desethylchloroquine, quinine, and quinidine in vitro.

D. Kyle, W. Milhous, W K Milhous, 1990, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Efflux of chloroquine from Plasmodium falciparum: mechanism of chloroquine resistance.

I. Gluzman, D. Kyle, W. Milhous, 1987, Science.

In vitro and in vivo reversal of chloroquine resistance in Plasmodium falciparum with promethazine.

L. Gerena, D. Kyle, W. Milhous, 1998, The American journal of tropical medicine and hygiene.

Discovery of Anti-Amoebic Inhibitors from Screening the MMV Pandemic Response Box on Balamuthia mandrillaris, Naegleria fowleri, and Acanthamoeba castellanii

D. Kyle, C. Rice, E. Troth, 2020, bioRxiv.

Arteether-induced brain injury in Macaca mulatta. I. The precerebellar nuclei: the lateral reticular nuclei, paramedian reticular nuclei, and perihypoglossal nuclei

H. Webster, D. Kyle, R. Bauman, 2000, Anatomy and Embryology.

Arteether: risks of two-week administration in Macaca mulatta.

H. Webster, D. Kyle, R. Bauman, 1997, The American journal of tropical medicine and hygiene.

Mefloquine Pharmacokinetic-Pharmacodynamic Models: Implications for Dosing and Resistance

Leon Aarons, Dennis E. Kyle, Julie A. Simpson, 2000, Antimicrobial Agents and Chemotherapy.

Innate resistance to new antimalarial drugs in Plasmodium falciparum from Nigeria.

D. Kyle, W. Milhous, A. Sowunmi, 1992, Transactions of the Royal Society of Tropical Medicine and Hygiene.

SPf66 malaria vaccine is safe and immunogenic in malaria naive adults in Thailand.

D. Kyle, C. Wongsrichanalai, A. Brockman, 1997, Acta tropica.

Angiogenesis inhibitors specific for methionine aminopeptidase 2 as drugs for malaria and leishmaniasis.

X. Su, J. Bujnicki, P. Chiang, 2002 .

Angiogenesis Inhibitors Specific for Methionine Aminopeptidase 2 as Drugs for Malaria and Leishmaniasis

Janusz M. Bujnicki, Diarmuid E. Nicholson, Dennis E. Kyle, 2002, Journal of Biomedical Science.

Occurrence of Metacercariae (Trematoda: Gymnophallidae) on Amphitrite ornata (Annelida: Terebellidae)

D. Kyle, G. P. Noblet, 1985 .

Seasonal distribution of thermotolerant free-living amoebae. II. Lake Issaqueena.

D. Kyle, G. P. Noblet, 1987, The Journal of protozoology.

Seasonal distribution of thermotolerant free-living amoebae. I. Willard's Pond.

D. Kyle, G. P. Noblet, 1986, The Journal of protozoology.

Polymorphisms in Plasmodium falciparum dhfr and dhps genes and age related in vivo sulfadoxine-pyrimethamine resistance in malaria-infected patients from Nigeria.

D. Wirth, D. Kyle, W. Milhous, 2005, Acta tropica.

Flow cytometric assessment of hydroxypyridinone iron chelators on in vitro growth of drug-resistant malaria.

H. Webster, D. Kyle, R. Udomsangpetch, 1997, Cytometry.

First evidence of polychaete intermediate hosts for Neospirorchis spp. marine turtle blood flukes (Trematoda: Spirorchiidae).

D. Kyle, Sasha V. Siegel, J. Oberstaller, 2018, International journal for parasitology.

Syntheses and antimalarial activities of 10-substituted deoxoartemisinins.

D. Kyle, H. Ziffer, E. Katz, 2000, Journal of medicinal chemistry.

Artemisinin‐induced dormancy in plasmodium falciparum: duration, recovery rates, and implications in treatment failure.

M. Gatton, J. Peters, Q. Cheng, 2010, The Journal of infectious diseases.

Effects of hydroxypyridinone iron chelators in combination with antimalarial drugs on the in vitro growth of Plasmodium falciparum.

D. Kyle, K. Pattanapanyasat, D. Heppner, 2001, The Southeast Asian journal of tropical medicine and public health.

Adaptation of a Thai multidrug-resistant C2A clone of Plasmodium falciparum to Aotus monkeys and its preliminary in vivo antimalarial drug efficacy-resistance profile.

D. Kyle, W. Milhous, N. Obaldía, 2009, The American journal of tropical medicine and hygiene.

Artemisinin-Resistant Plasmodium falciparum Parasites Exhibit Altered Patterns of Development in Infected Erythrocytes

D. Kyle, A. Hott, L. Morton, 2015, Antimicrobial Agents and Chemotherapy.

Deamplification of pfmdr1-Containing Amplicon on Chromosome 5 in Plasmodium falciparum Is Associated with Reduced Resistance to Artelinic Acid In Vitro

M. Gatton, J. Peters, Q. Cheng, 2010, Antimicrobial Agents and Chemotherapy.

Several alleles of the multidrug-resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum

A. Cowman, D. Kyle, S. Foote, 1990, Nature.

pfcrt Allelic Types with Two Novel Amino Acid Mutations in Chloroquine-Resistant Plasmodium falciparum Isolates from the Philippines

J. Baker, J. Peters, Q. Cheng, 2003, Antimicrobial Agents and Chemotherapy.

Amplification of pfmdr 1 associated with mefloquine and halofantrine resistance in Plasmodium falciparum from Thailand.

C. Wilson, D. Wirth, D. Kyle, 1993, Molecular and biochemical parasitology.

Role of pfmdr1 Amplification and Expression in Induction of Resistance to Artemisinin Derivatives in Plasmodium falciparum

J. Peters, Q. Cheng, L. Gerena, 2010, Antimicrobial Agents and Chemotherapy.

Synthesis and antimalarial activities of base-catalyzed adducts of 11-azaartemisinin.

D. Kyle, B. Mekonnen, H. Ziffer, 2000, Bioorganic & medicinal chemistry.

Structure and antimalarial activity of adducts of 11-azaartemisinin with conjugated terminal acetylenes.

D. Kyle, H. Ziffer, E. Katz, 1999, Bioorganic & medicinal chemistry letters.

Design, synthesis, and evaluation of new chemosensitizers in multi-drug-resistant Plasmodium falciparum.

L. Gerena, D. Kyle, W. Milhous, 2002, Journal of medicinal chemistry.

Radical curative efficacy of tafenoquine combination regimens in Plasmodium cynomolgi-infected Rhesus monkeys (Macaca mulatta)

D. Kyle, W. Milhous, J. Sattabongkot, 2011, Malaria Journal.

CNS and antimalarial activity of synthetic meridianin and psammopemmin analogs.

D. Kyle, C. Amsler, B. Baker, 2011, Bioorganic & medicinal chemistry.

Miniaturized Cultivation of Microbiota for Antimalarial Drug Discovery

D. Kyle, K. Pang, C. Pearce, 2016, Medicinal research reviews.

Fitness of artemisinin-resistant Plasmodium falciparum in vitro.

D. Kyle, M. S. Tucker, A. Hott, 2015, The Journal of antimicrobial chemotherapy.

Effects of Point Mutations in Plasmodium falciparum Dihydrofolate Reductase and Dihydropterate Synthase Genes on Clinical Outcomes and In Vitro Susceptibility to Sulfadoxine and Pyrimethamine

L. Gerena, D. Kyle, A. Magill, 2009, PloS one.

Physical linkage to drug resistance genes results in conservation of var genes among West Pacific Plasmodium falciparum isolates.

M. Gatton, J. Peters, Q. Cheng, 2006, The Journal of infectious diseases.

Evolution of a unique Plasmodium falciparum chloroquine-resistance phenotype in association with pfcrt polymorphism in Papua New Guinea and South America

P. Roepe, D. Kyle, D. Fidock, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase of isolates from the Amazon region of Brazil.

D. Wirth, D. Kyle, C. Plowe, 2000, Memorias do Instituto Oswaldo Cruz.

Association between mutations in Plasmodium falciparum chloroquine resistance transporter and P. falciparum multidrug resistance 1 genes and in vivo amodiaquine resistance in P. falciparum malaria-infected children in Nigeria.

D. Wirth, D. Kyle, W. Milhous, 2006, The American journal of tropical medicine and hygiene.

Origin and Dissemination of Chloroquine-Resistant Plasmodium falciparum with Mutant pfcrt Alleles in the Philippines

Danny W. Wilson, Q. Cheng, D. Kyle, 2005, Antimicrobial Agents and Chemotherapy.

Serial analysis of gene expression (SAGE) in Plasmodium falciparum: application of the technique to A-T rich genomes.

L. M. Cummings, D. Wirth, D. Kyle, 2001, Molecular and biochemical parasitology.

Chemogenomic profiling of Plasmodium falciparum as a tool to aid antimalarial drug discovery

Geoffrey H. Siwo, D. Kyle, Asako Tan, 2015, Scientific Reports.

Phenotypic and Genotypic Analysis of In Vitro-Selected Artemisinin-Resistant Progeny of Plasmodium falciparum

D. Kyle, Janus Patel, M. S. Tucker, 2011, Antimicrobial Agents and Chemotherapy.

Randomised double-blind placebo-controlled trial of SPf66 malaria vaccine in children in northwestern Thailand

D. Kyle, J. Wittes, W. Ballou, 1996, The Lancet.

Molecular analysis of Plasmodium falciparum recrudescent malaria infections in children treated with chloroquine in Nigeria.

L. Gerena, D. Wirth, D. Kyle, 2004, The American journal of tropical medicine and hygiene.

Randomised trial of mefloquine-tetracycline and quinine-tetracycline for acute uncomplicated falciparum malaria.

H. Webster, D. Kyle, S. Looareesuwan, 1994, Acta tropica.

Technical Assessment of the Affymetrix Yeast Expression GeneChip YE6100 Platform in a Heterologous Model of Genes That Confer Resistance to Antimalarial Drugs in Yeast

Dyann F. Wirth, Martin E. Nau, Dennis E. Kyle, 2000, Journal of Clinical Microbiology.

Genetic diversity of Plasmodium falciparum histidine-rich protein 2 (PfHRP2) and its effect on the performance of PfHRP2-based rapid diagnostic tests.

J. Baker, M. Gatton, J. McCarthy, 2005, The Journal of infectious diseases.

Diagnostic Characteristics of Lactate Dehydrogenase on a Multiplex Assay for Malaria Detection Including the Zoonotic Parasite Plasmodium knowlesi.

D. Kyle, R. Moon, G. Domingo, 2021, The American journal of tropical medicine and hygiene.

Strict tropism for CD71+/CD234+ human reticulocytes limits the zoonotic potential of Plasmodium cynomolgi.

D. Kyle, L. Rénia, F. Nosten, 2017, Blood.

Characterization of the Tubovesicular Network in Plasmodium vivax Liver Stage Hypnozoites and Schizonts

D. Kyle, Kayla Sylvester, B. Witkowski, 2021, Frontiers in Cellular and Infection Microbiology.

The tubovesicular network in Plasmodium vivax liver-stage hypnozoites and schizonts associates with host aquaporin 3

D. Kyle, Kayla Sylvester, B. Witkowski, 2020, bioRxiv.

Robust continuous in vitro culture of the Plasmodium cynomolgi erythrocytic stages

M. Galinski, D. Kyle, L. Rénia, 2019, Nature Communications.

A recombinant antibody against Plasmodium vivax UIS4 for distinguishing replicating from dormant liver stages

S. Kappe, D. Kyle, D. Sather, 2018, Malaria Journal.

A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum

S. Kappe, D. Kyle, C. Andolina, 2018, Nature Communications.

The epidemiology of malaria in a Karen population on the western border of Thailand.

H. Webster, D. Kyle, N. White, 1996, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Chloroquine resistant Plasmodium falciparum in indigenous residents of Cameroon.

L. Gerena, D. Kyle, W. Milhous, 1989, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Reversal of chloroquine resistance in malaria parasite Plasmodium falciparum by desipramine.

A. Bitonti, P. McCann, A. Sjoerdsma, 1988, Science.

Quinolone-3-Diarylethers: A New Class of Antimalarial Drug

Yuexin Li, David M. Shackleford, Susan A Charman, 2013, Science Translational Medicine.

(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium

Hongshen Ma, Zheng Wang, Jeremy Horst, 2014, Proceedings of the National Academy of Sciences.

Dynamics of infection and pathology induced by the aporocotylid, Cardicola laruei, in Spotted Seatrout, Cynoscion nebulosus (Sciaenidae).

D. Kyle, V. Connors, B. Nowak, 2020, International journal for parasitology.

Efficacy of scopadulcic acid A against Plasmodium falciparum in vitro.

D. Kyle, W. Milhous, M. Riel, 2002, Journal of natural products.

Novel Arylimidamides for Treatment of Visceral Leishmaniasis

R. Madhubala, D. Kyle, W. Wilson, 2010, Antimicrobial Agents and Chemotherapy.

Randomized dose-ranging study of the safety and efficacy of WR 238605 (Tafenoquine) in the prevention of relapse of Plasmodium vivax malaria in Thailand.

D. Braitman, D. Kyle, W. Milhous, 1999, The Journal of infectious diseases.

Open randomized trial of oral artemether alone and a sequential combination with mefloquine for acute uncomplicated falciparum malaria.

D. Kyle, P. Pitisuttithum, S. Looareesuwan, 1997, The American journal of tropical medicine and hygiene.

TREATMENT OF PATIENTS WITH RECRUDESCENT FALCIPARUM MALARIA WITH A SEQUENTIAL COMBINATION OF ARTESUNATE AND MEFLOQUINE

H. Webster, D. Kyle, S. Looareesuwan, 1992, The American journal of tropical medicine and hygiene.

Treatment of acute uncomplicated falciparum malaria with a short course of artesunate followed by mefloquine.

D. Kyle, S. Looareesuwan, C. Canfield, 1993, The Southeast Asian journal of tropical medicine and public health.

Reversal of Plasmodium falciparum resistance to chloroquine in Panamanian Aotus monkeys.

D. Kyle, W. Milhous, R. Rossan, 1993, The American journal of tropical medicine and hygiene.

Mefloquine treatment of acute falciparum malaria: a prospective study of non-serious adverse effects in 3673 patients.

R. Price, D. Kyle, N. White, 1995, Bulletin of the World Health Organization.

Failure to detect a Plasmodium vivax-like malaria parasite in globally collected blood samples.

K. Kain, D. Kyle, C. Wongsrichanalai, 1994, The Journal of infectious diseases.

Plasmodium falciparum: evaluation of lactate dehydrogenase in monitoring therapeutic responses to standard antimalarial drugs in Nigeria.

D. Kyle, W. Milhous, R. Piper, 1997, Experimental parasitology.

Blood meals from ‘dead-end’ vertebrate hosts enhance transmission potential of malaria-infected mosquitoes

D. Kyle, A. Pathak, Justine C. Shiau, 2022, bioRxiv.

ICI 56,780 Optimization: Structure-Activity Relationship Studies of 7-(2-Phenoxyethoxy)-4(1H)-quinolones with Antimalarial Activity.

D. Kyle, J. Burrows, Roman Manetsch, 2016, Journal of medicinal chemistry.

Fluoxetine hydrochloride enhances in vitro susceptibility to chloroquine in resistant Plasmodium falciparum

L. Gerena, D. Kyle, W. Milhous, 1992, Antimicrobial Agents and Chemotherapy.

Quinolone-3-Diarylethers : A new class of drugs for a new era of malaria eradication

David M. Shackleford, R. Price, M. Mather, 2014 .

Almiramides A-C: discovery and development of a new class of leishmaniasis lead compounds.

Roger G Linington, Roger G. Linington, William H Gerwick, 2010, Journal of medicinal chemistry.

Real-Time PCR to Quantify Leishmania donovani in Hamsters

D. Kyle, Azliyati Azizan, B. Vesely, 2013, The Journal of parasitology.

A potent antimalarial trichothecene from hyphomycete species

D. Kyle, C. Pearce, B. Baker, 2014 .

Flow cytometric immunophenotyping of lymphocyte subsets in samples that contain a high proportion of non-lymphoid cells.

D. Kyle, S. Fucharoen, P. Tongtawe, 1994, Cytometry.

Pharmacokinetics, efficacy and toxicity of parenteral halofantrine in uncomplicated malaria.

D. Kyle, N. White, S. Pukrittayakamee, 1993, British journal of clinical pharmacology.

Stage specific detection and inhibition studies of Plasmodium falciparum telomerase.

D. Kyle, W. Aldous, R. K. Martin, 1998, Molecular and biochemical parasitology.

Chemistry and Bioactivity of the Deep-Water Antarctic Octocoral Alcyonium sp.

D. Kyle, Xingmin Sun, Hiran Malinda Lamabadu Warnakulasuriya Patabendige, 2022, Marine drugs.

Reversal of Chloroquine Resistance of Plasmodium vivax in Aotus Monkeys

D. Kyle, W. Milhous, N. Obaldía, 2018, Antimicrobial Agents and Chemotherapy.

Aminoalkoxycarbonyloxymethyl Ether Prodrugs with a pH-Triggered Release Mechanism: A Case Study Improving the Solubility, Bioavailability, and Efficacy of Antimalarial 4(1H)-Quinolones with Single Dose Cures.

D. Kyle, P. Parvatkar, Roman Manetsch, 2021, Journal of medicinal chemistry.

Lengthy Antimalarial Activity of Atovaquone in Human Plasma following Atovaquone-Proguanil Administration

K. Rieckmann, D. Kyle, M. Good, 2005, Antimicrobial Agents and Chemotherapy.

Bioactivity of Spongian Diterpenoid Scaffolds from the Antarctic Sponge Dendrilla antarctica

D. Kyle, C. Amsler, L. Shaw, 2020, Marine drugs.

Vertical distribution of potentially pathogenic free-living amoebae in freshwater lakes.

D. Kyle, G. P. Noblet, 1985, The Journal of protozoology.

The shikimate pathway and its branches in apicomplexan parasites.

J. Finnerty, R. Lyons, J. Dame, 2002, The Journal of infectious diseases.

Triclosan inhibits the growth of Plasmodium falciparum and Toxoplasma gondii by inhibition of apicomplexan Fab I.

R. Lyons, D. Rice, C. Roberts, 2001, International journal for parasitology.

Characteristics of multidrug resistance in Plasmodium and Leishmania: detection of P-glycoprotein-like components.

D. Kyle, W. Milhous, M. Grogl, 1991, The American journal of tropical medicine and hygiene.

Pharmacokinetics of proguanil in malaria patients treated with proguanil plus atovaquone.

D. Kyle, S. Looareesuwan, M. Edstein, 1996, The Southeast Asian journal of tropical medicine and public health.

Randomized trial of mefloquine-doxycycline, and artesunate-doxycycline for treatment of acute uncomplicated falciparum malaria.

D. Kyle, S. Looareesuwan, C. Canfield, 1994, The American journal of tropical medicine and hygiene.

Drug Susceptibility and Genetic Evaluation of Plasmodium falciparum Isolates Obtained in Four Distinct Geographical Regions of Kenya

N. Waters, D. Kyle, R. Achilla, 2004, Antimicrobial Agents and Chemotherapy.

Artemisinin resistance in Plasmodium falciparum: A process linked to dormancy?

Qin Cheng, Michelle L Gatton, M. Gatton, 2012, International journal for parasitology. Drugs and drug resistance.

Long-term malaria chemoprophylaxis with mefloquine in Dutch marines in Cambodia.

D. Kyle, H. Lobel, M. Green, 1996, Journal of Infectious Diseases.

Pharmacokinetics of quinine and 3-hydroxyquinine in severe falciparum malaria with acute renal failure.

P. Newton, D. Kyle, S. Pukrittayakamee, 1999, Transactions of the Royal Society of Tropical Medicine and Hygiene.

A study of the factors affecting the metabolic clearance of quinine in malaria

D. Kyle, N. White, A. Smith, 1997, European Journal of Clinical Pharmacology.

Plasmodium vivax: isotopic, PicoGreen, and microscopic assays for measuring chloroquine sensitivity in fresh and cryopreserved isolates.

R. Price, D. Kyle, F. Nosten, 2006, Experimental parasitology.

Reversal of mefloquine resistance with penfluridol in isolates of Plasmodium falciparum from south-west Nigeria.

L. Gerena, D. Kyle, W. Milhous, 1993, Transactions of the Royal Society of Tropical Medicine and Hygiene.

WR 238605, chloroquine, and their combinations as blood schizonticides against a chloroquine-resistant strain of Plasmodium vivax in Aotus monkeys.

K. Rieckmann, D. Kyle, G. Shanks, 1997, The American journal of tropical medicine and hygiene.

Alkyne modified purines for assessing activation of Plasmodium vivax hypnozoites and growth of pre-erythrocytic and erythrocytic stages in Plasmodium spp

M. Cassera, E. F. Merino, D. Kyle, 2021, bioRxiv.

Phytohormones, Isoprenoids, and Role of the Apicoplast in Recovery from Dihydroartemisinin-Induced Dormancy of Plasmodium falciparum

D. Kyle, Marvin Duvalsaint, 2018, Antimicrobial Agents and Chemotherapy.

Altered drug susceptibility during host adaptation of a Plasmodium falciparum strain in a non-human primate model

L. Childs, C. Buckee, L. Gerena, 2016, Scientific Reports.

4-(1H)-Quinolones and 1,2,3,4-Tetrahydroacridin-9(10H)-Ones Prevent the Transmission of Plasmodium falciparum to Anopheles freeborni

D. Kyle, Roman Manetsch, Alexis N Lacrue, 2013, Antimicrobial Agents and Chemotherapy.

Lead Optimization of Antimalarial Propafenone Analogues ■ Introduction

J. Derisi, L. Tang, D. Kyle, 2022 .

Phenotypic and Genotypic Analysis of In Vitro Selected Artemisinin-Resistant 1 Progeny of Plasmodium falciparum 2

D. Kyle, Janus Patel, M. S. Tucker, 2011 .

A Drug Repurposing Approach Reveals Targetable Epigenetic Pathways in Plasmodium vivax Hypnozoites

S. Lonardi, M. Galinski, K. L. Le Roch, 2023, bioRxiv.

Antimalarial and antiproliferative evaluation of bis-steroidal tetraoxanes.

D. Kyle, W. Milhous, Z. Zizak, 2003, Bioorganic & medicinal chemistry.

Methyl-substituted dispiro-1,2,4,5-tetraoxanes: correlations of structural studies with antimalarial activity.

J. K. Wood, James K. Wood, D. Kyle, 2000, Journal of medicinal chemistry.

Syntheses and bioactivities of substituted 9,10-dihydro-9,10-[1,2]benzenoanthracene-1,4,5,8-tetrones. Unusual reactivities with amines.

P. Chiang, D. Kyle, D. Hua, 2002, The Journal of organic chemistry.

Liver-stage fate determination in Plasmodium vivax parasites: Characterization of schizont growth and hypnozoite fating from patient isolates

D. Kyle, B. Witkowski, A. Vantaux, 2022, bioRxiv.

Direct type I interferon signaling in hepatocytes controls malaria

D. Kyle, R. Vijay, S. P. Kurup, 2022, bioRxiv.

Plasmodium vivax Liver and Blood Stages Recruit the Druggable Host Membrane Channel Aquaporin-3

D. Kyle, Kayla Sylvester, J. Popovici, 2020, Cell chemical biology.

A Phenotypic Screen for the Liver Stages of Plasmodium vivax.

D. Kyle, C. Joyner, B. Witkowski, 2021, Bio-protocol.

Cryopreservation of Plasmodium Sporozoites

D. Kyle, S. P. Kurup, L. Hancox, 2022, Pathogens.

Pod inoculation technique with Phytophthora sojae to evaluate soybean populations for RPS alleles in field plantings

C. D. Nickell, D. Kyle, J. Hegstad, 1996 .

Relationship between Chloroquine Toxicity and Iron Acquisition in Saccharomyces cerevisiae

D. Wirth, D. Kyle, M. Nau, 2002, Antimicrobial Agents and Chemotherapy.

Altered cleavage of Caspase-1 in hepatocytes limits control of malaria in the liver

D. Kyle, S. P. Kurup, L. Hancox, 2021, bioRxiv.

The effects of α1-acid glycoprotein on the reversal of chloroquine resistance in Plasmodium falciparum

D. Kyle, A. Sowunmi, A. Oduola, 2006 .

Phenotypic and Genotypic Analysis of In Vitro Selected Artemisinin-Resistant

D. Kyle, Janus Patel, M. S. Tucker, 2011 .

Shagenes A and B, new tricyclic sesquiterpenes produced by an undescribed Antarctic octocoral.

D. Kyle, B. Baker, B. Vesely, 2014, Organic Letters.

Efficacy of Proton Pump Inhibitor Drugs against Plasmodium falciparum In Vitro and Their Probable Pharmacophores

D. Kyle, W. Milhous, A. Bhattacharjee, 2002, Antimicrobial Agents and Chemotherapy.

Open-source discovery of chemical leads for next-generation chemoprotective antimalarials

Manuel Llinás, Yingyao Zhou, David A. Fidock, 2018, Science.

Synthesis and Activity of a New Series of Antileishmanial Agents.

D. Kyle, Benjamin J. Eduful, A. Azhari, 2017, ACS medicinal chemistry letters.

Acid catalyzed Michael additions to artemisitene.

D. Kyle, H. Ziffer, J. Ma, 2000, Bioorganic & medicinal chemistry letters.

Evidence for mitochondrial-derived alternative oxidase in the apicomplexan parasite Cryptosporidium parvum: a potential anti-microbial agent target.

F. Roberts, C. Roberts, D. Kyle, 2004, International journal for parasitology.

Antimalarial pharmacodynamics and pharmacokinetics of a third-generation antifolate--JPC2056--in cynomolgus monkeys using an in vivo in vitro model.

K. Rieckmann, D. Kyle, M. Edstein, 2007, The Journal of antimicrobial chemotherapy.

A recombinant antibody against Plasmodium vivax UIS4 for distinguishing replicating from dormant liver stages

S. Kappe, D. Kyle, D. Sather, 2018, Malaria Journal.

The effects of alpha1-acid glycoprotein on the reversal of chloroquine resistance in Plasmodium falciparum.

L. Gerena, D. Kyle, W. Milhous, 2006, Annals of Tropical Medicine and Parasitology.

Naegleria fowleri: Protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoeba

P. Myler, D. Kyle, I. Phan, 2020, bioRxiv.

Mefloquine treatment ofacutefalciparum malaria: aprospective studyofnon-serious adverse effects in3673patients

R. Price, D. Kyle, F. Nosten, 1995 .

Plasmodium falciparum-Based Bioassay for Measurement of Artemisinin Derivatives in Plasma or Serum

H. Webster, D. Kyle, N. White, 2004, Antimicrobial Agents and Chemotherapy.

Integrative Genetic Manipulation of Plasmodium cynomolgi Reveals Multidrug Resistance-1 Y976F Associated With Increased In Vitro Susceptibility to Mefloquine

D. Kyle, D. Fidock, L. Rénia, 2022, The Journal of infectious diseases.

Comparison of beta-artemether and beta-arteether against malaria parasites in vitro and in vivo.

D. Kyle, C. Canfield, A. Ager, 1993, The American journal of tropical medicine and hygiene.

Mitochondrial heteroplasmy is responsible for Atovaquone drug resistance in Plasmodium falciparum

D. Kyle, Chengqi Wang, R. Jiang, 2017, bioRxiv.

Synthesis of Mono- and Bisperoxide-Bridged Artemisinin Dimers to Elucidate the Contribution of Dimerization to Antimalarial Activity.

D. Kyle, Roman Manetsch, Victoria C Mendiola, 2021, ACS infectious diseases.

Erratum: (+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium (Proceedings of the National Academy of Sciences of the United States of America (2014) 111 (E5455-E5462) 1 DOI: 10.1073/pnas.1414221111)

Anang A. Shelat, Zheng Wang, Jeremy A. Horst, 2015 .

Synthesis and in vitro studies of novel pyrimidinyl peptidomimetics as potential antimalarial therapeutic agents.

D. Kyle, T. Hudson, A. Lin, 2002, Journal of medicinal chemistry.

A nonhuman primate model for human cerebral malaria: effects of artesunate (qinghaosu derivative) on rhesus monkeys experimentally infected with Plasmodium coatneyi.

H. Webster, D. Kyle, C. Ockenhouse, 1993, The American journal of tropical medicine and hygiene.

Fatty Acid Synthesis and Pyruvate Metabolism Pathways Remain Active in Dihydroartemisinin-Induced Dormant Ring Stages of Plasmodium falciparum

M. Gatton, Q. Cheng, N. Waters, 2014, Antimicrobial Agents and Chemotherapy.

Qualitative and semiquantitative polymerase chain reaction to predict Plasmodium falciparum treatment failure.

H. Webster, K. Kain, D. Kyle, 1994, The Journal of infectious diseases.

Randomized, controlled, double-blind trial of daily oral azithromycin in adults for the prophylaxis of Plasmodium vivax malaria in Western Thailand.

D. Kyle, C. Wongsrichanalai, Robert E. Miller, 2005, The American journal of tropical medicine and hygiene.

Evaluation of Artemisone Combinations in Aotus Monkeys Infected with Plasmodium falciparum

K. Rieckmann, D. Kyle, M. Edstein, 2009, Antimicrobial Agents and Chemotherapy.

Culture of malaria parasites in two different red blood cell populations using biotin and flow cytometry.

H. Webster, D. Kyle, P. Tongtawe, 1996, Cytometry.

Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis

E. Winzeler, S. Meister, J. Rayner, 2016, Nature.

Reply: Shikimate pathway in apicomplexan parasites

J. Finnerty, D. Chakrabarti, F. Roberts, 1999, Nature.

Multiple drug resistance of Plasmodium falciparum in Liberia.

D. Kyle, A. Oduola, P. Broadbent, 1989, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Identification of novel anti-amoebic pharmacophores from kinase inhibitor chemotypes

D. Kyle, F. Gamarro, D. González-Pacanowska, 2023, Frontiers in Microbiology.

AIM2 sensors mediate immunity to Plasmodium infection in hepatocytes

D. Kyle, S. P. Kurup, L. Hancox, 2023, Proceedings of the National Academy of Sciences of the United States of America.

Disposition of proguanil in Thai patients with uncomplicated falciparum malaria.

K. Rieckmann, D. Kyle, S. Looareesuwan, 1997, The American journal of tropical medicine and hygiene.

Efficacy comparison of intravenous artelinate and artesunate in Plasmodium berghei-infected Sprague-Dawley rats

D. Kyle, G. Dow, Y. Si, 2003, Parasitology.

Menoctone Resistance in Malaria Parasites Is Conferred by M133I Mutations in Cytochrome b That Are Transmissible through Mosquitoes

D. Kyle, Sasha V. Siegel, Roman Manetsch, 2017, Antimicrobial Agents and Chemotherapy.

Design and Synthesis of Orally Bioavailable Piperazine Substituted 4(1H)-Quinolones with Potent Antimalarial Activity: Structure-Activity and Structure-Property Relationship Studies.

D. Kyle, J. Burrows, Raghupathi Neelarapu, 2017, Journal of medicinal chemistry.

Field trials of an asexual blood stage malaria vaccine: studies of the synthetic peptide polymer SPf66 in Thailand and the analytic plan for a phase IIb efficacy study

D. Kyle, F. Nosten, P. Singhasivanon, 1995, Parasitology.

Proguanil polymorphism does not affect the antimalarial activity of proguanil combined with atovaquone in vitro.

A. E. Yeo, K. Rieckmann, D. Kyle, 1996, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Malaria causal prophylactic activity of imidazolidinedione derivatives.

D. Kyle, W. Milhous, A. Magill, 2007, Journal of medicinal chemistry.

Unambiguous synthesis and prophylactic antimalarial activities of imidazolidinedione derivatives.

J. Sacci, D. Kyle, W. Milhous, 2005, Journal of medicinal chemistry.

Title: A Drug Repurposing Approach Reveals Targetable Epigenetic Pathways in Plasmodium vivax Hypnozoites

S. Lonardi, M. Galinski, K. L. Le Roch, 2023 .

Adaptation of a Thai multidrug-resistant C2A clone of Plasmodium falciparum to Aotus monkeys and its preliminary in vivo antimalarial drug efficacy-resistance profile.

D. Kyle, W. Milhous, N. Obaldía, 2009, The American journal of tropical medicine and hygiene.

Synthesis, antimalarial activity, and structure-activity relationship of 7-(2-phenoxyethoxy)-4(1H)-quinolones.

D. Kyle, Roman Manetsch, R. M. Cross, 2011, Journal of medicinal chemistry.

Identification of a Hit Series of Antileishmanial Compounds through the Use of Mixture-Based Libraries.

D. Kyle, M. Giulianotti, R. Houghten, 2017, ACS medicinal chemistry letters.