Y. Wataya

发表

New neplanocin analogues. 12. Alternative synthesis and antimalarial effect of (6'R)-6'-C-methylneplanocin A, a potent AdoHcy hydrolase inhibitor.

S. Shuto, N. Minakawa, S. Niizuma, 2002, Journal of medicinal chemistry.

Reaction of sodium bisulfite with uracil, cytosine, and their derivatives.

Y. Wataya, H. Hayatsu, K. Kai, 1970, Biochemistry.

Rhodacyanine dyes as antimalarials. 1. Preliminary evaluation of their activity and toxicity.

Hye-Sook Kim, Y. Wataya, H. Inoue, 2002, Journal of medicinal chemistry.

Species-specific PCR detection of malaria parasites by microtiter plate hybridization: clinical study with malaria patients

Hye-Sook Kim, Y. Wataya, M. Kimura, 1995, Journal of clinical microbiology.

Identification of the four species of human malaria parasites by nested PCR that targets variant sequences in the small subunit rRNA gene

Y. Wataya, O. Kaneko, M. Kimura, 1997 .

Thymidylate synthetase. Catalysis of dehalogenation of 5-bromo- and 5-iodo-2'-deoxyuridylate.

Y. Wataya, D. Santi, C. Garrett, 1979, Biochemistry.

Chromanone Derivatives from the Pericarps of Calophyllum polyanthum

Y. Wataya, Chun-lin Long, Yue-Hu Wang, 2010 .

Antimalarial effect of bis-pyridinium salts, N,N'-hexamethylenebis(4-carbamoyl-1-alkylpyridinium bromide).

Y. Wataya, H. Kourai, Munehiro Yoshida, 2006, Bioorganic & medicinal chemistry letters.

Improvement of Oral Bioavailability of N-251, a Novel Antimalarial Drug, by Increasing Lymphatic Transport with Long-Chain Fatty Acid-Based Self-Nanoemulsifying Drug Delivery System

Hye-Sook Kim, Y. Wataya, M. Kuramoto, 2015, Pharmaceutical Research.

Potent in vivo antimalarial activity of 3,15-di-O-acetylbruceolide against Plasmodium berghei infection in mice.

Y. Wataya, Y. Ishizuka, N. Murakami, 2000, Parasitology international.

Fecal mutagenicity arising from ingestion of fried ground beef in the human.

Y. Wataya, H. Hayatsu, H. Mower, 1985, Mutation research.

Potent Antimalarial Activity of Two Arenes Linked with Triamine Designed To Have Multiple Interactions with Heme.

Hye-Sook Kim, Y. Wataya, Yuko Kobayashi, 2018, ACS medicinal chemistry letters.

Antimalarial activity of endoperoxide compound 6-(1,2,6,7-tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol.

Hye-Sook Kim, Y. Wataya, H. Hayatsu, 2011, Parasitology international.

Antisense oligodeoxynucleotides: useful tool for search and assessment of new targets for anti-malarial drugs.

S. Shuto, Y. Wataya, A. Matsuda, 1999, Nucleic acids symposium series.

Toxoplasma gondii: a simple high-throughput assay for drug screening in vitro.

Hye-Sook Kim, Y. Wataya, Hyun Park, 2009, Experimental parasitology.

Molecular Mechanism of 5-Fluoro-2′-deoxyuridine-induced dNTP Imbalance Cell Death: Purification of an Endonuclease Involved in DNA Double Strand Breaks During dNTP Imbalance Death

Y. Wataya, H. Hwang, T. Igaki, 1995 .

Imbalance of Deoxyribonucleoside Triphosphates and DNA Double‐strand Breaks in Mouse Mammary Tumor FM3A Cells Treated in vitro with an Antineoplastic Tropolone Derivative

Y. Wataya, H. Hayatsu, T. Morita, 1992, Japanese journal of cancer research : Gann.

Imbalance of deoxyribonucleoside triphosphates, DNA double-strand breaks, and cell death caused by 2-chlorodeoxyadenosine in mouse FM3A cells.

Y. Wataya, A. Matsuda, K. Watanabe, 1989, Cancer research.

The mechanism of 2-chlorodeoxyadenosine-induced cell death.

Y. Wataya, A. Matsuda, J. Minowada, 1989, Advances in experimental medicine and biology.

A specialized form of chromosomal DNA degradation induced by thymidylate stress in mouse FM3A cells.

Y. Wataya, T. Seno, D. Ayusawa, 1988, Mutation research.

Antimalarial activity of 6-(1,2,6,7-tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol (N-251) and its carboxylic acid derivatives.

Hye-Sook Kim, Y. Wataya, H. Hayatsu, 2011, Parasitology international.

Role of activating transcription factor 3 protein ATF3 in necrosis and apoptosis induced by 5‐fluoro‐2′‐deoxyuridine

Hye-Sook Kim, Y. Wataya, M. Masutani, 2014, The FEBS journal.

Association of Nuclear Membrane Protein Lamin B1 with Necrosis and Apoptosis in Cell Death Induced by 5-Fluoro-2′-Deoxyuridine

Hye-Sook Kim, Y. Wataya, Akira Sato, 2008, Nucleosides, nucleotides & nucleic acids.

Preparation of quinoline hexose analogs as novel chloroquine-resistant malaria treatments (1). Synthesis of 4-hydroxyquinoline-beta-glucosides.

Hye-Sook Kim, Y. Wataya, I. Tamai, 2007, Chemical & pharmaceutical bulletin.

DNA strand cleavage in vitro by 3-hydroxyamino-1-methyl-5H-pyrido[4,3-b]-indole, a direct-acting mutagen formed in the metabolism of carcinogenic 3-amino-1-methyl-5H-pyrido[4,3-b]indole.

Y. Wataya, A. Wakata, H. Hayatsu, 1985, Cancer research.

Co-catalyzed autoxidation of alkene in the presence of silane. The effect of the structure of silanes on the efficiency of the reaction and on the product distribution

Hye-Sook Kim, Y. Wataya, T. Tokuyasu, 2005 .

Yingzhaosu A analogues: synthesis by the ozonolysis of unsaturated hydroperoxides, structural analysis and determination of anti-malarial activity

Hye-Sook Kim, Y. Wataya, T. Tokuyasu, 2001 .

Synthesis, crystal structure and antimalarial activity of novel 1,2,5,6-tetraoxacycloalkanes from 2,3-dihydroperoxy-2-phenylnorbornane

Hye-Sook Kim, Y. Wataya, A. Masuyama, 1999 .

Synthetic methods for unsymmetrically-substituted 1,2,4,5-tetroxanes and of 1,2,4,5,7-pentoxocanes

Hye-Sook Kim, Y. Wataya, Yoshihiro Ushigoe, 1999 .

Anti-parasite activity of nucleoside analogues in Leishmania tropica promastigotes.

Y. Wataya, A. Matsuda, M. Saneyoshi, 1984, Nucleic acids symposium series.

Activation of c-jun and c-fos genes in dNTP imbalance cell death induced with 5-fluoro-2'-deoxyuridine in mouse mammary tumor FM3A cell line.

Y. Wataya, K. Takahashi, T. Kakutani, 1998, Nucleosides & nucleotides.

Conformation of Escherichia coli glutamic acid tRNA II as studied by hydrogen-tritium exchange catalyzed by cysteine methyl ester.

Y. Wataya, H. Takagi, H. Hayatsu, 1976, European journal of biochemistry.

Epidemiological and clinical aspects of malaria in Japan.

Y. Wataya, K. Nakajima, H. Ohtomo, 2006, Journal of travel medicine.

Role of bisulfite in the deamination and the hydrogen isotope exchange of cytidylic acid.

Y. Wataya, H. Hayatsu, M. Sono, 1973, Journal of the American Chemical Society.

Evaluation of preclinical antimalarial drugs, which can overcome direct-acting antivirals-resistant hepatitis C viruses, using the viral reporter assay systems.

Hye-Sook Kim, Y. Wataya, N. Kato, 2017, Virus research.

New Preclinical Antimalarial Drugs Potently Inhibit Hepatitis C Virus Genotype 1b RNA Replication

Hye-Sook Kim, Y. Wataya, N. Kato, 2013, PloS one.

Different modes of cell death induced by 5-fluoro-2'-deoxyuridine in two clones of the mouse mammary tumor FM3A cell line.

Y. Wataya, Y. Matsumoto, M. Hidaka, 1998, Biochemical and biophysical research communications.

Synthesis of novel ferrocenyl sugars and their antimalarial activities.

Y. Wataya, H. S. Kim, Y. Yamashita, 2000, Bioorganic & medicinal chemistry letters.

GENERATION OF INTRACELLULAR ACTIVE OXYGENS IN MOUSE FM3A CELLS BY 3‐HYDROXYAMINO‐1‐METHYL‐5H‐PYRIDO[4,3‐b]INDOLE, THE ACTIVATED TRP‐P‐2

Y. Wataya, H. Hayatsu, K. Negishi, 1988, Japanese journal of cancer research : Gann.

Synthesis and notable antimalarial activity of acyclic peroxides, L-(alkyldioxy)-L-(methyldioxy)cyclododecanes.

Hye-Sook Kim, Y. Wataya, A. Masuyama, 2002, Journal of medicinal chemistry.

Antimalarial and Cytotoxic Activities of Bicyclo[6.4.0]dodecenones

Hye-Sook Kim, Y. Wataya, Takuma Sasaki, 2001 .

Different behavior of artemisinin and tetraoxane in the oxidative degradation of phospholipid.

Hye-Sook Kim, Y. Wataya, Minoru Izumi, 2009, Chemistry and physics of lipids.

Synthesis of Novel Conjugates of Tetraoxane Endoperoxide with Bis(Quaternary Ammonium Salts)

Hye-Sook Kim, Y. Wataya, Minoru Izumi, 2009, Bioscience, biotechnology, and biochemistry.

[6] Use of secondary α-hydrogen isotope effects in reactions of pyrimidine nucleoside/nucleotide metabolism: Thymidylate synthetase

Y. Wataya, D. Santi, T. W. Bruice, 1980 .

Cycloprodigiosin hydrochloride obtained from Pseudoalteromonas denitrificans is a potent antimalarial agent.

T. Mitamura, Y. Wataya, Y. Moriyama, 1999, Biological & pharmaceutical bulletin.

Synthesis of 2-fluoronoraristeromycin and its inhibitory activity against Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase.

Y. Kitade, Hye-Sook Kim, Y. Wataya, 2003, Bioorganic & medicinal chemistry letters.

New type of febrifugine analogues, bearing a quinolizidine moiety, show potent antimalarial activity against Plasmodium malaria parasite.

Y. Wataya, Y. Oshima, H. S. Kim, 1999, Journal of medicinal chemistry.

Synthesis and evaluation of beta-carbolinium cations as new antimalarial agents based on pi-delocalized lipophilic cation (DLC) hypothesis.

Hye-Sook Kim, Y. Wataya, R. Brun, 2005, Chemical & pharmaceutical bulletin.

In vitro antimalarial activity of metalloporphyrins against Plasmodium falciparum

Hye-Sook Kim, Y. Wataya, I. Stojiljković, 2003, Parasitology Research.

Potent antimalarial febrifugine analogues against the plasmodium malaria parasite.

Hye-Sook Kim, Y. Wataya, H. Kikuchi, 2002, Journal of medicinal chemistry.

New type of febrifugine analogues, bearing a quinolizidine moiety, show potent antimalarial activity against Plasmodium malaria parasite.

Y. Wataya, Y. Oshima, H. S. Kim, 1999, Journal of medicinal chemistry.

Synthesis, crystal structure and anti-malarial activity of novel spiro- 1,2,4,5-tetraoxacycloalkanes

Hye-Sook Kim, Y. Wataya, A. Masuyama, 1999 .

Structure-activity relationships of quaternary protoberberine alkaloids having an antimalarial activity

Hye-Sook Kim, Y. Wataya, T. Yamori, 1999 .

Synthesis and antitumor activity of tropolone derivatives. 7. Bistropolones containing connecting methylene chains.

T. Tsuruo, Y. Wataya, K. Sakaki, 1992, Journal of medicinal chemistry.

Catalytic Asymmetric Synthesis of Antimalarial Alkaloids Febrifugine and Isofebrifugine and Their Biological Activity.

Hye-Sook Kim, Y. Wataya, M. Ueno, 1999, The Journal of organic chemistry.

Synthesis and antimalarial activity of febrifugine derivatives.

Y. Wataya, H. S. Kim, H. Abe, 2001, Chemical & pharmaceutical bulletin.

Asymmetric synthesis of (+)-febrifugine and (+)-isofebrifugine using yeast reduction

Hye-Sook Kim, Y. Wataya, H. Abe, 2001 .

Metabolites of febrifugine and its synthetic analogue by mouse liver S9 and their antimalarial activity against Plasmodium malaria parasite.

Hye-Sook Kim, Y. Wataya, H. Kikuchi, 2003, Journal of medicinal chemistry.

Catalytic Asymmetric Synthesis of Antimalarial Alkaloids Febrifugine and Isofebrifugine and Their Biological Activity.

Hye-Sook Kim, Y. Wataya, M. Ueno, 1999, The Journal of organic chemistry.

Synthesis and Antimalarial Activity of dl-Deoxyfebrifugine

Hye-Sook Kim, Y. Wataya, S. Tokuda, 1999 .

Novel Guaiane Endoperoxides, Nardoguaianone A–D, from Nardostachys chinensis Roots and their Antinociceptive and Antimalarial Activities

Hye-Sook Kim, Y. Wataya, Y. Oshima, 2000 .

Novel antimalarial guaiane-type sesquiterpenoids from Nardostachys chinensis roots

Hye-Sook Kim, Y. Wataya, Y. Oshima, 1998 .

Simple isoquinoline and benzylisoquinoline alkaloids as potential antimicrobial, antimalarial, cytotoxic, and anti-HIV agents.

Y. Wataya, K. Lee, M. Kozuka, 2001, Bioorganic & medicinal chemistry.

Antimalarial 4-quinazolinone alkaloids from Dichroa febrifuga (JOH-ZAN)

Y. Wataya, Y. Oshima, Y. Takaya, 1998 .

ChemInform Abstract: Potent Antimalarial Febrifugine (V) Analogues Against the Plasmodium Malaria Parasite.

Hye-Sook Kim, Y. Wataya, H. Kikuchi, 2002 .

Synthesis and antimalarial activity of cyclic peroxides, 1,2,4,5, 7-pentoxocanes and 1,2,4,5-tetroxanes.

Y. Wataya, H. S. Kim, Y. Shibata, 1999, Journal of medicinal chemistry.

Applications of triphenylpyrylium salt-sensitized electron-transfer photo-oxygenation reactions to the synthesis of benzo-fused 1,4-diaryl-2,3-dioxabicyclo[2.2.2]octanes as new antimalarial cyclic peroxides

Hye-Sook Kim, Y. Wataya, M. Kamata, 2012, Research on Chemical Intermediates.

Synthesis, crystal structure and anti-malarial activity of functionalized spiro-1,2,4,5-tetraoxacycloalkanes from unsaturated hydroperoxy peracetals

Hye-Sook Kim, Y. Wataya, T. Tokuyasu, 2000 .

Synthesis and antimalarial activity of novel medium-sized 1,2,4,5-tetraoxacycloalkanes.

Y. Wataya, H. S. Kim, A. Masuyama, 2001, Journal of medicinal chemistry.

Iron(II)-promoted rearrangement of 1,4-diaryl-2,3-dioxabicyclo[2.2.2]oct-5-enes: a mechanism distinct from that postulated previously

Hye-Sook Kim, Y. Wataya, M. Kamata, 2002 .

π-Delocalized β-carbolinium cations as potential antimalarials

Hye-Sook Kim, Y. Wataya, K. Takasu, 2004 .

Thymidine phosphorylase. Substrate specificity for 5-substituted 2'-deoxyuridines.

Y. Wataya, D. Santi, M. Saneyoshi, 1980, Journal of medicinal chemistry.

Thymidylate synthetase: fluorine-19 nmr characterization of the active site peptide covalently bound to 5-fluoro-2'-deoxyuridylate and 5,10-methylenetetrahydrofolate.

Y. Wataya, D. Santi, T. James, 1976, Biochemical and biophysical research communications.

INHIBITORS OF THYMIDYLATE SYNTHETASE

Y. Wataya, A. Matsuda, D. Santi, 1979 .

Andirolides H–P from the flower of andiroba (Carapa guianensis, Meliaceae)

Hye-Sook Kim, Y. Wataya, Takanobu Inoue, 2012 .

In vitro antiplasmodial activity of antimalarial medicinal plants used in Vietnamese traditional medicine.

Shigetoshi Kadota, Yasuhiro Tezuka, Jun-ya Ueda, 2003, Journal of ethnopharmacology.

Antimalarial activity and structure-activity relationships of protoberberine alkaloids

Hye-Sook Kim, Y. Wataya, Dong-Ung Lee, 1998 .

Interaction of thymidylate synthetase with 5-nitro-2'-deoxyuridylate.

Y. Wataya, A. Matsuda, D. Santi, 1980, The Journal of biological chemistry.

5-Nitro-2'-deoxyuridylate: a mechanism-based inhibitor of thymidylate synthetase.

Y. Wataya, A. Matsuda, D. Santi, 1978, Biochemical and biophysical research communications.

Inhibition of Lactobacillus casei thymidylate synthetase by 5-substituted 2'-deoxyuridylates. Preliminary quantitative structure-activity relationship.

C. Hansch, Y. Wataya, D. Santi, 1977, Journal of medicinal chemistry.

An improved method for the quantitative determination of deoxyribonucleoside triphosphates in cell extracts.

Y. Wataya, K. Tanaka, A. Yoshioka, 1984, Analytical biochemistry.

Schistosomicidal and antifecundity effects of oral treatment of synthetic endoperoxide N-89.

S. Ichinose, Hye-Sook Kim, Y. Wataya, 2011, Parasitology international.

Transformation of Cinchona alkaloids into 1-N-oxide derivatives by endophytic Xylaria sp isolated from Cinchona pubescens.

Hye-Sook Kim, Y. Wataya, P. Simanjuntak, 2003, Chemical & pharmaceutical bulletin.

Effect of amines on the bisulfite-catalyzed hydrogen isotope exchange at the 5 position of uridine.

Y. Wataya, H. Hayatsu, 1972, Biochemistry.

Cysteine-catalyzed hydrogen isotope exchange at position 5 of uridylic acid.

Y. Wataya, H. Hayatsu, Y. Kawazoe, 1973, Journal of biochemistry.

Cysteine-catalyzed hydrogen isotope exchange at the 5 position of uridylic acid.

Y. Wataya, H. Hayatsu, Y. Kawazoe, 1972, Journal of the American Chemical Society.

Bisulfite-catalyzed isotope labeling of cytidine 5'-phosphate at its 5 position.

Y. Wataya, H. Hayatsu, K. Kai, 1971, Journal of the American Chemical Society.

Clinical characteristics of imported malaria in Japan: analysis at a referral hospital.

T. Miura, Y. Wataya, Tetsuya Nakamura, 2005, The American journal of tropical medicine and hygiene.

Chemical modification of tRNAyeastTyr with bisulfite. A new method to modify isopentenyladenosine residue

Y. Wataya, Y. Furuichi, H. Hayatsu, 1970 .

Antimalarial activity of lavandulyl flavanones isolated from the roots of Sophora flavescens.

Hye-Sook Kim, Y. Wataya, D. Sohn, 2004, Biological & pharmaceutical bulletin.

Antitumor mechanisms and metabolism of the novel antitumor nucleoside analogues, 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine and 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)uracil

M. Fukushima, Y. Wataya, A. Matsuda, 1999, Cancer Chemotherapy and Pharmacology.

Thymidylate synthetase catalyzed dehalogenation of 5-bromo-and 5-iodo-2'-deoxyuridylate.

Y. Wataya, D. Santi, 1975, Biochemical and biophysical research communications.

Debromination of 5-bromo-2'-deoxyuridine by cysteine. Formation of deoxyuridine and S-(5-(2'-deoxyuridyl))cysteine.

Y. Wataya, H. Hayatsu, K. Negishi, 1973, Biochemistry.

Carbocyclic inosine as a potent anti-leishmanial agent: the metabolism and selective cytotoxic effects of carbocyclic inosine in promastigotes of Leishmania tropica and Leishmania donovani.

Y. Wataya, A. Matsuda, O. Hiraoka, 1986, Biochemical and biophysical research communications.

Synthesis of 5'-methylenearisteromycin and its 2-fluoro derivative with potent antimalarial activity due to inhibition of the parasite S-adenosylhomocysteine hydrolase.

Y. Kitade, S. Shuto, Hye-Sook Kim, 2005, Organic & biomolecular chemistry.

Role of RNase L in apoptosis induced by 1-(3-C-ethynyl-β-d-ribo-pentofuranosyl)cytosine

M. Fukushima, Y. Kitade, Hye-Sook Kim, 2009, Cancer Chemotherapy and Pharmacology.

A novel apoptotic pathway of 3'-Ethynylcytidine(ECyd) involving the inhibition of RNA synthesis--the possibility of RNase L activated pathway as a target of ECyd.

M. Fukushima, Y. Kitade, Hye-Sook Kim, 2007, Nucleic acids symposium series.

Continuous spectrophotometric assay of thymidine phosphorylase using 5-nitro-2'-deoxyuridine as substrate.

Y. Wataya, D. Santi, 1981, Analytical Biochemistry.

3′-Deoxy-3′-fluoroinosine as a potent antileishmanial agent

Y. Wataya, Y. Morizawa, I. Shin, 1995, Parasitology Research.

Leishmania donovani: pilot study for evaluation of therapeutic effects of inosine analogs against amastigotes in vitro and in vivo.

Y. Wataya, A. Ishii, T. Aji, 1995, Experimental parasitology.

Antitumor activity and novel DNA‐self‐strand‐breaking mechanism of CNDAC (1‐(2‐C‐cyano‐2‐deoxy‐β‐d‐ARABINO‐Pentofuranosyl) cytosine) and its N4‐palmitoyl derivative (CS‐682)

A. Tomida, T. Tsuruo, Y. Wataya, 1999, International journal of cancer.

A new antitumor nucleoside, 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine (ECyd), is a potent inhibitor of RNA synthesis.

M. Fukushima, Y. Wataya, A. Matsuda, 1999, Nucleosides & nucleotides.

1-(3-C-Ethynyl-beta-D-ribo-pentofuranosyl)cytosine (ECyd, TAS-106), a novel potent inhibitor of RNA polymerase, potentiates the cytotoxicity of CDDP in human cancer cells both in vitro and in vivo.

A. Fujioka, M. Fukushima, Y. Wataya, 2009, International Journal of Oncology.

Rapid, Stepwise Substitution of Fluorines In 5-Trifluoromethyl-2′-Deoxyuridine by Bisulfite

Y. Wataya, A. Matsuda, H. Hayatsu, 1994 .

trans-5-(3,3,3-Trifluoro-1-propenyl-)-2'-deoxyuridylate: a mechanism-based inhibitor of thymidylate synthetase.

Y. Wataya, A. Matsuda, D. Santi, 1979, Journal of medicinal chemistry.

Antitumor activity of FTC-092, a masked 5-trifluoromethyl-2′-deoxyuridine derivative

Y. Wataya, J. Uchida, Yuji Yamada, 2004, Cancer Chemotherapy and Pharmacology.

The addition of sodium bisulfite to uracil and to cytosine.

Y. Wataya, H. Hayatsu, K. Kai, 1970, Journal of the American Chemical Society.

Different Mechanisms of Inhibition of DNA Synthesis by (E)-5-(2-Bromovinyl)-2′-deoxyuridine in Cells Transfected with Gene for Thymidine Kinase of Herpes Simplex Virus Type 1 and in Cells Infected with the Virus

Y. Wataya, Y. Arao, Y. Hirota, 1995 .

A secondary isotope effect in the cysteine-Promoted dehalogenation of 5-bromo-2'-deoxyuridine. evidence for transient 5,6-dihydropyrimidine intermediates.

Y. Wataya, D. Santi, 1977, Journal of the American Chemical Society.

Thymidylate Synthetase: Interaction with 5-Fluoro and 5-Trifluoromethyl-2′-Deoxyuridylic Acid

Y. Wataya, D. Santi, T. James, 1976 .

Anticancer Strategy Targeting Cell Death Regulators: Switching the Mechanism of Anticancer Floxuridine-Induced Cell Death from Necrosis to Apoptosis

Hye-Sook Kim, Y. Wataya, Akira Sato, 2020, International journal of molecular sciences.

Active-site labeling of thymidylate synthetase with 5-fluoro-2'-deoxyuridylate.

Y. Wataya, D. Santi, 1977, Methods in enzymology.

Reaction of bisulphite with N6-(Δ2-isopentenyl)adenosine

Y. Wataya, Y. Furuichi, H. Hayatsu, 1972 .

The characterization of cell death induced by 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl) cytosine (ECyd) in FM3A cells.

M. Fukushima, Y. Wataya, A. Matsuda, 1998, Nucleosides & nucleotides.

Synthesis of novel siRNAs having thymidine dimers consisting of a carbamate or a urea linkage at their 3' overhang regions and their ability to suppress human RNase L protein expression.

Y. Kitade, Hye-Sook Kim, Y. Wataya, 2005, Biochemical and biophysical research communications.

THERAPEUTIC EFFECT OF INOSINE ANALOGS IN MICE INFECTED WITH LEISHMANIA DONO-VANI OR TR YPANOSOMA GAMBIENSE

Y. Wataya, A. Matsuda, T. Ueda, 1988 .

3'-Deoxyinosine as an anti-leishmanial agent: the metabolism and cytotoxic effects of 3'-deoxyinosine in Leishmania tropica promastigotes.

Y. Wataya, O. Hiraoka, 1984, Biochemical and biophysical research communications.

Cloning and expression of uridine/cytidine kinase cDNA from human fibrosarcoma cells.

M. Fukushima, Y. Wataya, A. Matsuda, 2001, International journal of molecular medicine.

Role of the uridine/cytidine kinase 2 mutation in cellular sensitiveness toward 3′-ethynylcytidine treatment of human cancer cells

M. Fukushima, Hye-Sook Kim, Y. Wataya, 2017, Anti-cancer drugs.

Analysis of single nucleotide polymorphisms in uridine/cytidine kinase gene encoding metabolic enzyme of 3'-ethynylcytidine.

Y. Wataya, A. Matsuda, Hey-Sook Kim, 2002, Nucleic acids research. Supplement.

A New Antitumor Nucleoside, 1-(3-C-Ethynyl-β-D-ribo-pentofuranosyl)cytosine (ECyd), is a Potent Inhibitor of RNA Synthesis

M. Fukushima, Y. Wataya, A. Matsuda, 1999 .

Geranyl Derivatives of Isoquinoline Alkaloids Show Increased Biological Activities

S. Takeuchi, Hye-Sook Kim, Y. Wataya, 2010 .

Characterization of Nucleoside Phosphotransferase from Leishmania Tropica

Y. Wataya, I. Shin, 1995 .

Potentiation of the antitumor activity of 5-trifluoromethyl-2′-deoxyuridine by the use of depot forms of the parent compound

Y. Wataya, K. Wierzba, Yuji Yamada, 2004, Cancer Chemotherapy and Pharmacology.

Synthesis and silencing properties of siRNAs possessing lipophilic groups at their 3'-termini.

Y. Kitade, Hye-Sook Kim, Y. Wataya, 2008, Bioorganic & medicinal chemistry.

Adenosine kinase is a key determinant for the anti‐HCV activity of ribavirin

Y. Wataya, N. Kato, M. Ikeda, 2013, Hepatology.

Association of RNase L with a Ras GTPase‐activating‐like protein IQGAP1 in mediating the apoptosis of a human cancer cell‐line

Yukio Kitade, Akiko Hiramoto, M. Fukushima, 2010, The FEBS journal.

(ECyd, TAS-106), a novel potent inhibitor of RNA polymerase, potentiates the cytotoxicity of CDDP in human cancer cells both in vitro and in vivo

A. Fujioka, M. Fukushima, Y. Wataya, 2009 .

Mechanisms of cell death induced by 5-fluoro-2'-deoxyuridine (FUdR)--necrosis or apoptosis after treated with FUdR.

Hye-Sook Kim, Y. Wataya, S. Mitani, 2002, Nucleic acids research. Supplement.

Deoxyribonucleoside triphosphate imbalance. 5-Fluorodeoxyuridine-induced DNA double strand breaks in mouse FM3A cells and the mechanism of cell death.

Y. Wataya, T. Seno, D. Ayusawa, 1987, The Journal of biological chemistry.

Deoxyribonucleoside-triphosphate imbalance death: deoxyadenosine-induced dNTP imbalance and DNA double strand breaks in mouse FM3A cells and the mechanism of cell death.

Y. Wataya, O. Hiraoka, Y. Hirota, 1987, Biochemical and biophysical research communications.

Reaction of 5-trifluoromethyl-2′-deoxyuridine and 1-methyl-5-trifluoromethyluracil with methoxyamine: model studies for the interaction between thymidylate synthetase and 5-trifluoromethyl-2′-deoxyuridine 5′-phosphate

M. Aida, Y. Wataya, D. Santi, 1987 .

TRANS-5-(3,3,3-TRIFLUORO-1-PROPENYL)-2′-DEOXYURIDYLATE: A MECHANISM-BASED INHIBITOR OF THYMIDYLATE SYNTHETASE

Y. Wataya, A. Matsuda, D. Santi, 1979 .

Gene expression profiles of necrosis and apoptosis induced by 5-fluoro-2'-deoxyuridine.

T. Miyake, Hye-Sook Kim, Y. Wataya, 2008, Genomics.

Sequence variation in the 18S rRNA gene, a target for PCR-based malaria diagnosis, in Plasmodium ovale from southern Vietnam

Y. Wataya, O. Kaneko, S. Isomura, 1996, Journal of clinical microbiology.

Use of blue cotton for detection of mutagenicity in human feces excreted after ingestion of cooked meat.

Y. Wataya, H. Hayatsu, T. Hayatsu, 1986, Environmental health perspectives.

Plasmodium falciparum endoplasmic reticulum-resident calcium binding protein is a possible target of synthetic antimalarial endoperoxides, N-89 and N-251.

Hye-Sook Kim, Y. Wataya, O. Kaneko, 2012, Journal of proteome research.

A Colorimetric DNA Diagnostic Method for Falciparum Malaria and Vivax Malaria: A Field Trial in the Solomon Islands

Hye-Sook Kim, Y. Wataya, H. Miyake, 1996 .

DNA diagnosis of ovale malaria and malariae malaria using microtiter plate-hybridization

Y. Wataya, M. Arai, M. Kimura, 1994 .

MicroRNA-351 Regulates Two-Types of Cell Death, Necrosis and Apoptosis, Induced by 5-fluoro-2'-deoxyuridine

Hye-Sook Kim, Y. Wataya, M. Masutani, 2016, PloS one.

Parasite infection and cancer: with special emphasis on Schistosoma japonicum infections (Trematoda). A review.

Y. Wataya, H. Hayatsu, N. Ohta, 1994, Mutation research.

Novel Guaiane Endoperoxides, Nardoguaianone A—D, from Nardostachys chinensis Roots and Their Antinociceptive and Antimalarial Activities.

Hye-Sook Kim, Y. Wataya, Y. Oshima, 2001 .

Detection of malaria parasites in mosquitoes from the malaria-endemic area of Chakaria, Bangladesh.

Hye-Sook Kim, Y. Wataya, Y. Wagatsuma, 2008, Biological & pharmaceutical bulletin.

A trial for a DNA diagnosis of Plasmodium vivax malaria recently reemerging in the Republic of Korea using microtiter plate hybridization assay.

H. S. Kim, Y. Wataya, K. Oh, 2000, The American journal of tropical medicine and hygiene.

Modified metabolism of a carcinogen, 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2), by liver S9 from Schistosoma japonicum-infected mice.

Y. Wataya, H. Hayatsu, S. Arimoto, 1992, Mutation research.

Reduced levels of mutagen processing potential in the Schistosoma japonicum-infected mouse liver.

Y. Wataya, H. Hayatsu, S. Arimoto, 1989, Mutation research.

Evaluation of the mutagenicity and the tumor-promoting activity of parasite extracts: Schistosoma japonicum and Clonorchis sinensis.

Y. Wataya, H. Tokuda, H. Hayatsu, 1989, Mutation research.

Acute disseminated encephalomyelitis following Plasmodium vivax malaria

T. Miura, Hye-Sook Kim, Y. Wataya, 2003, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.

Duffy antigen is important for the lethal effect of the lethal strain of Plasmodium yoelii 17XL

Hye-Sook Kim, Y. Wataya, N. Akimitsu, 2004, Parasitology Research.

Sequence Analysis of the 5′-Flanking Regions of Human Dihydropyrimidine Dehydrogenase Gene: Identification of a New Polymorphism Related with Effects of 5-Fluorouracil

M. Fukushima, Hye-Sook Kim, Y. Wataya, 2005, Nucleosides, nucleotides & nucleic acids.

DEOXYRIBONUCLEOSIDE TRIPHOSPHATES IN MOUSE FETAL LIVER CELLS ASSAYED BY HIGH-PRESSURE LIQUID CHROMATOGRAPHY

Y. Wataya, H. Hayatsu, Minoru Nakamura, 1998 .

Synthesis of antimalarial yingzhaosu A analogues by the peroxidation of dienes with Co(II)/O2/Et3SiH.

Hye-Sook Kim, Y. Wataya, M. Abe, 2003, The Journal of organic chemistry.

DNA diagnosis of falciparum malaria using a double PCR technique: a field trial in the Solomon Islands.

Y. Wataya, N. Ohta, M. Arai, 1993, Molecular and biochemical parasitology.

Proteome analysis of new antimalarial endoperoxide against Plasmodium falciparum

Hye-Sook Kim, Y. Wataya, H. Kataoka, 2007, Parasitology Research.

Selective accumulation of rhodacyanine in plasmodial mitochondria is related to the growth inhibition of malaria parasites

S. Kuge, A. Naganuma, Hye-Sook Kim, 2010 .

Anti-malarial activities of acylated bruceolide derivatives.

Y. Wataya, T. Mahmud, N. Murakami, 1998, Bioorganic & medicinal chemistry letters.

Design, synthesis and in vitro antimalarial activity of spiroperoxides

Hye-Sook Kim, Y. Wataya, Qi Zhang, 2006 .

Genomic and biological features of Plasmodium falciparum resistance against antimalarial endoperoxide N-89.

Hye-Sook Kim, Y. Wataya, S. Miyoshi, 2019, Gene.

Stage specific activity of synthetic antimalarial endoperoxides, N-89 and N-251, against Plasmodium falciparum.

Hye-Sook Kim, Y. Wataya, Akira Sato, 2015, Parasitology international.

A Homologue ofN-Ethylmaleimide-sensitive Factor in the Malaria ParasitePlasmodium falciparum Is Exported and Localized in Vesicular Structures in the Cytoplasm of Infected Erythrocytes in the Brefeldin A-sensitive Pathway*

Hye-Sook Kim, Y. Wataya, Y. Moriyama, 2001, The Journal of Biological Chemistry.

New semisynthetic quassinoids with in vivo antimalarial activity.

Hye-Sook Kim, Y. Wataya, Motomasa Kobayashi, 2003, Journal of medicinal chemistry.

Antimalarial activity and nucleoside transport inhibitory activity of the triterpenic constituents of Cimicifuga spp.

Y. Wataya, H. S. Kim, G. Kusano, 1998, Biological and Pharmaceutical Bulletin.

1,2,4,5-Tetraoxacycloalkanes: synthesis and antimalarial activity.

Y. Wataya, A. Masuyama, M. Nojima, 2005, Mini reviews in medicinal chemistry.

Synthesis and in vitro antimalarial activity of several simple analogues of peroxyplakoric acid

Hye-Sook Kim, Y. Wataya, Qi Zhang, 2005 .

Synthesis of carbocyclic and acyclic nucleosides possessing 2-fluoroadenine derivatives and their inhibitory activities against Plasmodium falciparum SAH hydrolase.

Y. Kitade, M. Nakanishi, Hye-Sook Kim, 2003, Nucleic acids research. Supplement.

Molecular mechanism of cell death induced dNTP pool imbalance.

Y. Wataya, H. Hwang, K. Takahashi, 1993, Nucleic acids symposium series.

Mutagenicity of (p-nitrophenyl)adenines in Salmonella typhimurium.

Y. Wataya, A. Matsuda, H. Hayatsu, 1991, Mutation research.

Detection of Plasmodium falciparum in human blood by a nested polymerase chain reaction.

Y. Wataya, M. Arai, T. Kakutani, 1994, The American journal of tropical medicine and hygiene.

Genetic analysis of mefloquine-resistant mechanism of Plasmodium falciparum.

Hye-Sook Kim, Y. Wataya, Yuko Nishiyama, 2004, Nucleic acids symposium series.

Improvement of Oral Bioavailability of N-251, a Novel Antimalarial Drug, by Increasing Lymphatic Transport with Long-Chain Fatty Acid-Based Self-Nanoemulsifying Drug Delivery System

Hye-Sook Kim, Y. Wataya, M. Kuramoto, 2015, Pharmaceutical Research.

Mechanism-based inhibition of thymidylate synthase by 5-(trifluoromethyl)-2'-deoxyuridine 5'-monophosphate.

J. Finer-Moore, Y. Wataya, D. Santi, 1994, Biochemistry.

Cytotoxic mechanisms of new antitumor nucleoside analogues, 3'-ethynylcytidine (ECyd) and 3'-ethynyluridine (EUrd).

M. Fukushima, Y. Wataya, A. Matsuda, 1997, Nucleic acids symposium series.

Parallel synthesis of antimalarial rhodacyanine dyes by the combination of three components in one pot.

Hye-Sook Kim, Y. Wataya, H. Inoue, 2003, Journal of combinatorial chemistry.

Pi-delocalized beta-carbolinium cations as potential antimalarials.

Hye-Sook Kim, Y. Wataya, K. Takasu, 2004, Bioorganic & medicinal chemistry letters.

Analysis of Pfmdr 1 gene in mefloquine-resistant Plasmodium falciparum.

Y. Wataya, H. S. Kim, K. Begum, 2001, Nucleic acids research. Supplement.

Inhibition of the mutagenicity of cooked-beef basic fraction by its acidic fraction.

Y. Wataya, H. Ohta, H. Hayatsu, 1981, Mutation research.

A potent antimalarial activity of 5-fluoroorotate in combination with sulfamonomethoxine against Plasmodium falciparum in vitro and Plasmodium berghei in mice

Hye-Sook Kim, Y. Wataya, H. Miyake, 1998 .

DNA diagnosis of falciparum malaria.

Y. Wataya, K. Watanabe, M. Arai, 1991, Nucleic Acids Symposium Series.

Synthesis, Fe(II)-induced degradation, and antimalarial activities of 1,5-diaryl-6,7-dioxabicyclo[3.2.2]nonanes: direct evidence for nucleophilic O-1,2-aryl shifts

Hye-Sook Kim, Y. Wataya, M. Kamata, 2002 .

Fe(II)-mediated fragmentation of 1,4-diaryl-2,3-dioxabicyclo[2.2.2]octanes through competitive single electron transfer pathway and Lewis acid pathway

Hye-Sook Kim, Y. Wataya, M. Kamata, 2002 .

π-Delocalized β-Carbolinium Cations as Potential Antimalarials.

Hye-Sook Kim, Y. Wataya, K. Takasu, 2004 .

Synthesis and Biological Activity of Fatty Acid Derivatives of Quinine

Hye-Sook Kim, Y. Wataya, Minoru Izumi, 2005, Bioscience, biotechnology, and biochemistry.

Direct interaction analysis of microRNA-351-5p and nuclear scaffold lamin B1 mRNA by the cell-free in vitro mRNA/miRNA binding evaluation system

Hye-Sook Kim, Y. Wataya, Akira Sato, 2020, Nucleosides, nucleotides & nucleic acids.

Unique properties of respiratory chain in Plasmodium falciparum mitochondria.

Hye-Sook Kim, Y. Wataya, A. Matsuda, 2003, Advances in experimental medicine and biology.

Inhibitory Mechanisms of 1-(3-C-Ethynyl-β-d-ribo-Pentofuranosyl)Uracil (EUrd) on RNA Synthesis

M. Fukushima, Hye-Sook Kim, Y. Wataya, 2005 .