M. Phillips

发表

High-throughput Screening for Potent and Selective Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase*

P. Rathod, John White, J. Baldwin, 2005, Journal of Biological Chemistry.

Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export

C. Forst, D. Levy, M. Roth, 2012, The Journal of cell biology.

Chemical genetics of Plasmodium falciparum

Anang A. Shelat, David S. Roos, John S. Lazo, 2010, Nature.

Structure Prediction and Active Site Analysis of the Metal Binding Determinants in γ-Glutamylcysteine Synthetase*

Jimin Pei, Nick V. Grishin, Margaret A. Phillips, 2001, The Journal of Biological Chemistry.

Modeling of the spatial structure of eukaryotic ornithine decarboxylases

N. Grishin, E. Goldsmith, M. Phillips, 1995, Protein science : a publication of the Protein Society.

Advanced molecular design of biopolymers for transmucosal and intracellular delivery of chemotherapeutic agents and biological therapeutics.

William B. Liechty, M. Phillips, N. Peppas, 2011, Journal of controlled release : official journal of the Controlled Release Society.

Malarial Dihydroorotate Dehydrogenase

Pradipsinh K Rathod, P. Rathod, J. Baldwin, 2002, The Journal of Biological Chemistry.

A dual regulatory circuit consisting of S-adenosylmethionine decarboxylase protein and its reaction product controls expression of the paralogous activator prozyme in Trypanosoma brucei

M. Phillips, A. Lemoff, Manish M Patel, 2018, PLoS pathogens.

Target validation for drug discovery in parasitic organisms.

M. Phillips, L. Jackson, 2002, Current topics in medicinal chemistry.

An Alternative Polyamine Biosynthetic Pathway Is Widespread in Bacteria and Essential for Biofilm Formation in Vibrio cholerae*

V. Sperandio, M. Phillips, A. Camilli, 2009, Journal of Biological Chemistry.

Phylogenetic Diversity and the Structural Basis of Substrate Specificity in the β/α-Barrel Fold Basic Amino Acid Decarboxylases*

E. Goldsmith, M. Phillips, A. Michael, 2007, Journal of Biological Chemistry.

Polyamine Biosynthesis Provides Insight into Regulation of Trypanosoma brucei Synthase Genes in Ornithine Decarboxylase and Spermidine RNA Interference-Mediated Silencing of

M. Phillips, Yanjing Xiao, D. McCloskey, 2009 .

Deoxyhypusine Modification of Eukaryotic Translation Initiation Factor 5A (eIF5A) Is Essential for Trypanosoma brucei Growth and for Expression of Polyprolyl-containing Proteins*

N. Grishin, L. Kinch, M. Phillips, 2015, The Journal of Biological Chemistry.

Structural Plasticity of Malaria Dihydroorotate Dehydrogenase Allows Selective Binding of Diverse Chemical Scaffolds*

Werner Kaminsky, Pradipsinh K Rathod, Xiaoyi Deng, 2009, The Journal of Biological Chemistry.

Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity

P. Rathod, John White, M. Phillips, 2016, Journal of medicinal chemistry.

Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH)

Eloi P Coutant, Eloi P. Coutant, P. Vidalain, 2015, Journal of medicinal chemistry.

Anti-malarial Activity in the Mouse Model Dihydroorotate Dehydrogenase with Plasmodium falciparum Novel Inhibitors of Molecular Bases of Disease :

Margaret A. Phillips, Elizabeth J. Goldsmith, Dyann F. Wirth, 2010 .

Polyamine and glutathione biosynthetic enzymes from Trypanosoma brucei and Trypanosoma cruzi.

L. Kinch, M. Phillips, D. Brekken, 2000 .

Assessing drug efficacy against Plasmodium falciparum liver stages in vivo.

Erika L. Flannery, S. Kappe, Nelly Camargo, 2018, JCI insight.

Identification of Trypanosoma brucei AdoMetDC Inhibitors Using a High-Throughput Mass Spectrometry-Based Assay.

T. E. Richardson, M. Phillips, B. Posner, 2017, ACS infectious diseases.

X-ray structure of Paramecium bursaria Chlorella virus arginine decarboxylase: insight into the structural basis for substrate specificity.

E. Goldsmith, M. Phillips, R. Akella, 2007, Biochemistry.

Species-Selective Pyrimidineamine Inhibitors of Trypanosoma brucei S-Adenosylmethionine Decarboxylase.

M. Phillips, M. Peel, J. D. De Brabander, 2018, Journal of medicinal chemistry.

A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria.

David M. Shackleford, R. Price, P. Rathod, 2016, ACS infectious diseases.

Optimization of a non-radioactive high-throughput assay for decarboxylase enzymes.

J. Baldwin, M. Phillips, A. Shelat, 2010, Assay and drug development technologies.

Trypanosome ornithine decarboxylase is stable because it lacks sequences found in the carboxyl terminus of the mouse enzyme which target the latter for intracellular degradation.

M. Phillips, C. Wang, L. Ghoda, 1990, The Journal of biological chemistry.

Polyamines in protozoan pathogens

M. Phillips, 2018, The Journal of Biological Chemistry.

Trypanosoma brucei gamma-glutamylcysteine synthetase. Characterization of the kinetic mechanism and the role of Cys-319 in cystamine inactivation.

M. Phillips, D. Brekken, Deirdre Brekken, 1998, The Journal of biological chemistry.

A Trypanosoma brucei mutant resistant to α-difluoromethylornithine

M. Phillips, Ching C. Wang, C. C. Wang, 1987 .

Ornithine decarboxylase promotes catalysis by binding the carboxylate in a buried pocket containing phenylalanine 397.

M. Phillips, H. Brooks, L. Jackson, 2003, Biochemistry.

Multiple active site conformations revealed by distant site mutation in ornithine decarboxylase.

E. Goldsmith, J. Baldwin, M. Phillips, 2004, Biochemistry.

Pyrimidine Salvage Enzymes Are Essential for De Novo Biosynthesis of Deoxypyrimidine Nucleotides in Trypanosoma brucei

Jennifer J. Kohler, N. Grishin, L. Kinch, 2016, PLoS pathogens.

Evolution and Multifarious Horizontal Transfer of an Alternative Biosynthetic Pathway for the Alternative Polyamine sym-Homospermidine*♦

L. Kinch, M. Phillips, A. Michael, 2010, The Journal of Biological Chemistry.

State of the art in African trypanosome drug discovery.

M. Phillips, B. Nare, R. Jacobs, 2011, Current topics in medicinal chemistry.

Stoking the drug target pipeline for human African trypanosomiasis

M. Phillips, 2012, Molecular microbiology.

Phosphatidylinositol 4-Kinase III-β Is Required for Golgi Maintenance and Cytokinesis in Trypanosoma brucei

M. Phillips, J. Albanesi, M. J. Rodgers, 2007, Eukaryotic Cell.

Proteases

R. Fletterick, M. Phillips, 1992, Current Biology.

Discovery of Potent and Selective Inhibitors of Trypanosoma brucei Ornithine Decarboxylase*

M. Phillips, A. Shelat, R. Guy, 2010, The Journal of Biological Chemistry.

A fast-killing tyrosine amide ((S)-SW228703) with blood and liver-stage antimalarial activity associated with the Cyclic Amine Resistance Locus (PfCARL)

E. Winzeler, M. Phillips, F. Gamo, 2022, bioRxiv.

Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in Plasmodium falciparum.

E. Winzeler, D. Fidock, M. Phillips, 2021, Journal of medicinal chemistry.

A Gateway® compatible vector for gene silencing in bloodstream form Trypanosoma brucei.

M. Phillips, S. Kalidas, Qiong Li, 2011, Molecular and biochemical parasitology.

Total synthesis of (+)-spiroindimicin A and congeners unveils their antiparasitic activity

M. Phillips, P. Mallipeddi, H. Niederstrasser, 2021, Chemical science.

Formation of functional cross-species heterodimers of ornithine decarboxylase.

N. Grishin, L. Kinch, A. Osterman, 1994, Biochemistry.

Domain organization and a protease-sensitive loop in eukaryotic ornithine decarboxylase.

A. Osterman, M. Phillips, B. Canagarajah, 1995, Biochemistry.

Phylogenetic diversity and the structural basis of substrate specificity in the beta/alpha-barrel fold basic amino acid decarboxylases.

E. Goldsmith, M. Phillips, A. Michael, 2007, The Journal of biological chemistry.

Cloning and kinetic characterization of the Trypanosoma cruzi S-adenosylmethionine decarboxylase.

L. Kinch, M. Phillips, J. R. Scott, 1999, Molecular and biochemical parasitology.

Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif

Farah El Mazouni, I. Gilbert, M. Barrett, 2010, Bioorganic & medicinal chemistry letters.

Cross-species activation of trypanosome S-adenosylmethionine decarboxylase by the regulatory subunit prozyme.

M. Phillips, Erin K Willert, Erin K. Willert, 2009, Molecular and biochemical parasitology.

Crystallization and preliminary X‐ray studies of ornithine decarboxylase from Trypanosoma brucei

N. Grishin, E. Goldsmith, A. Osterman, 1996, Proteins.

Role of Arg-277 in the binding of pyridoxal 5'-phosphate to Trypanosoma brucei ornithine decarboxylase.

J. Rizo, A. Osterman, M. Phillips, 1997, Biochemistry.

Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study

J. McCarthy, D. Fidock, M. Phillips, 2017, The Lancet. Infectious diseases.

Development of a biomarker to monitor target engagement after treatment with dihydroorotate dehydrogenase inhibitors.

M. Phillips, Michael A. Pontikos, Jessica A. Kilgore, 2022, Biochemical pharmacology.

Evaluation of Antigens for Development of a Serological Test for Human African Trypanosomiasis

Richard McCulloch, Jean-Charles Sanchez, Mark Carrington, 2016, PloS one.

Mechanisms of allosteric regulation of Trypanosoma cruzi S-adenosylmethionine decarboxylase.

M. Phillips, T. Beswick, Erin K. Willert, 2006, Biochemistry.

Product feedback regulation implicated in translational control of the Trypanosoma brucei S‐adenosylmethionine decarboxylase regulatory subunit prozyme

M. Phillips, B. Tu, O. Volkov, 2013, Molecular microbiology.

Lead optimization of 3-carboxyl-4(1H)-quinolones to deliver orally bioavailable antimalarials.

D. Kyle, M. Phillips, J. Gow, 2012, Journal of medicinal chemistry.

Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity

David M. Shackleford, P. Rathod, John White, 2018, ACS omega.

Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors

Jeremy N. Burrows, Werner Kaminsky, Margaret A. Phillips, 2014, Journal of medicinal chemistry.

Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice.

David M. Shackleford, Pradipsinh K Rathod, Karen L White, 2009, Journal of medicinal chemistry.

Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum.

P. Rathod, John White, J. Baldwin, 2008, Journal of medicinal chemistry.

Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice.

David M. Shackleford, Susan A Charman, Pradipsinh K Rathod, 2011, Journal of medicinal chemistry.

Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase.

P. Rathod, F. Buckner, John White, 2012, Journal of medicinal chemistry.

Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential.

David M. Shackleford, Francisco-Javier Gamo, Xiaoyi Deng, 2011, Journal of medicinal chemistry.

Trypanosomatid Deoxyhypusine Synthase Activity Is Dependent on Shared Active-Site Complementation between Pseudoenzyme Paralogs.

M. Phillips, D. Tomchick, Gustavo A. Afanador, 2018, Structure.

Anticancer Properties of Distinct Antimalarial Drug Classes

K. Chibale, M. Phillips, R. Guy, 2013, PloS one.

Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy.

Pradipsinh K Rathod, P. Rathod, M. Phillips, 2010, Infectious disorders drug targets.

Alternative pathways utilize or circumvent putrescine for biosynthesis of putrescine-containing rhizoferrin

M. Phillips, D. Tomchick, A. Michael, 2020, The Journal of biological chemistry.

Altering the reaction specificity of eukaryotic ornithine decarboxylase.

E. Goldsmith, A. Osterman, M. Phillips, 2000, Biochemistry.

Targeting the Polyamine Biosynthetic Pathway in Parasitic Protozoa

M. Phillips, Nahir Velez, 2015 .

Regulation and function of polyamines in African trypanosomes.

M. Phillips, Erin K. Willert, 2012, Trends in parasitology.

IDENTIFICATION OF PROPRIETARY DRUGS

M. Phillips, 1960 .

Discovery of ancestral L-ornithine and L-lysine decarboxylases reveals parallel, pseudoconvergent evolution of polyamine biosynthesis

M. Phillips, A. Michael, Jue Liang, 2021, The Journal of biological chemistry.

Discovery of new S-adenosylmethionine decarboxylase inhibitors for the treatment of Human African Trypanosomiasis (HAT).

R. Barker, M. Phillips, B. Nare, 2009, Bioorganic & medicinal chemistry letters.

Regulated Expression of an Essential Allosteric Activator of Polyamine Biosynthesis in African Trypanosomes

M. Phillips, Erin K. Willert, 2008, PLoS pathogens.

Allosteric regulation of an essential trypanosome polyamine biosynthetic enzyme by a catalytically dead homolog

M. Phillips, R. Fitzpatrick, Erin K. Willert, 2007, Proceedings of the National Academy of Sciences.

Trypanosoma brucei S-Adenosylmethionine Decarboxylase N Terminus Is Essential for Allosteric Activation by the Regulatory Subunit Prozyme*

M. Phillips, C. Brautigam, Nahir Velez, 2013, The Journal of Biological Chemistry.

RNA Interference-Mediated Silencing of Ornithine Decarboxylase and Spermidine Synthase Genes in Trypanosoma brucei Provides Insight into Regulation of Polyamine Biosynthesis

M. Phillips, Yanjing Xiao, D. McCloskey, 2009, Eukaryotic Cell.

Crystal structure of human ornithine decarboxylase at 2.1 A resolution: structural insights to antizyme binding.

N. Grishin, A. Kern, M. Phillips, 2000, Journal of molecular biology.

GMP synthase is essential for viability and infectivity of Trypanosoma brucei despite a redundant purine salvage pathway

K. Stuart, M. Phillips, B. Tu, 2015, Molecular microbiology.

Characterization of Trypanosoma brucei pyridoxal kinase: purification, gene isolation and expression in Escherichia coli.

M. Phillips, T. Scott, 1997, Molecular and biochemical parasitology.

Acidic Residues Important for Substrate Binding and Cofactor Reactivity in Eukaryotic Ornithine Decarboxylase Identified by Alanine Scanning Mutagenesis (*)

N. Grishin, L. Kinch, A. Osterman, 1995, The Journal of Biological Chemistry.

Antizyme Ornithine Decarboxylase

M. Phillips, D. Myers, 2002 .

Asexual Populations of the Human Malaria Parasite, Plasmodium falciparum, Use a Two-Step Genomic Strategy to Acquire Accurate, Beneficial DNA Amplifications

Jennifer L. Guler, J. Derisi, P. Rathod, 2013, PLoS pathogens.

Yeast dihydroorotate dehydrogenase as a new selectable marker for Plasmodium falciparum transfection.

P. Rathod, M. Mather, A. Vaidya, 2011, Molecular and biochemical parasitology.

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

Farah El Mazouni, T. Laird, P. Rathod, 2015, Science Translational Medicine.

A Multiple Aminoacyl-tRNA Synthetase Complex That Enhances tRNA-Aminoacylation in African Trypanosomes

K. Stuart, M. Phillips, A. Anupama, 2013, Molecular and Cellular Biology.

Trypanosomesion in African Complex That Enhances A Multiple Aminoacyl-tRNA Synthetase

K. Stuart, M. Phillips, Igor Cestari, 2013 .

Characterization of Trypanosoma brucei γ-Glutamylcysteine Synthetase, an Essential Enzyme in the Biosynthesis of Trypanothione (Diglutathionylspermidine)*

M. Phillips, Deirdre V. Lueder, 1996, The Journal of Biological Chemistry.

Genetic Validation of Aminoacyl-tRNA Synthetases as Drug Targets in Trypanosoma brucei

K. Stuart, M. Phillips, M. Parsons, 2014, Eukaryotic Cell.

Novel S-Adenosylmethionine Decarboxylase Inhibitors for the Treatment of Human African Trypanosomiasis

R. Barker, M. Phillips, N. Yarlett, 2009, Antimicrobial Agents and Chemotherapy.

Alternative Spermidine Biosynthetic Route Is Critical for Growth of Campylobacter jejuni and Is the Dominant Polyamine Pathway in Human Gut Microbiota*

B. Pearson, M. Phillips, P. Woster, 2011, The Journal of Biological Chemistry.

Fluoroacetamide as a Systemic Insecticide

M. Phillips, C. Chapman, 1958, Nature.

Targeted Nanodelivery of Drugs and Diagnostics.

Nicholas A Peppas, M. Phillips, N. Peppas, 2010, Nano today.

Functional polyamine metabolic enzymes and pathways encoded by the virosphere

M. Phillips, A. Michael, Jue Liang, 2023, Proceedings of the National Academy of Sciences of the United States of America.

Cloning and sequencing of the ornithine decarboxylase gene from Trypanosoma brucei. Implications for enzyme turnover and selective difluoromethylornithine inhibition.

M. Phillips, C. Wang, P. Coffino, 1987, The Journal of biological chemistry.

Gene Knockdown of γ-Glutamylcysteine Synthetase by RNAi in the Parasitic Protozoa Trypanosoma brucei Demonstrates That It Is an Essential Enzyme*

M. Phillips, Van A T Huynh, T. Huynh, 2003, Journal of Biological Chemistry.

Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies

J. Luft, F. Buckner, C. Verlinde, 2008, Molecular microbiology.

Acid Hydrolysis of Sulphapyridines

M. Phillips, 1946, Nature.

Trypanosoma brucei: effects of methoprene and other isoprenoid compounds on procyclic and bloodstream forms in vitro and in mice.

Y. Li, M. Phillips, D. Mangelsdorf, 1997, Experimental parasitology.

Catalysis and regulationProteases

R. Fletterick, M. Phillips, 1992 .

The X-ray structure of Plasmodium falciparum dihydroorotate dehydrogenase bound to a potent and selective N-phenylbenzamide inhibitor reveals novel binding-site interactions.

P. Rathod, M. Phillips, D. Matthews, 2015, Acta crystallographica. Section F, Structural biology communications.

Long-range interactions in the dimer interface of ornithine decarboxylase are important for enzyme function.

G. Murphy, M. Phillips, L. Jackson, 2001, Biochemistry.

Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a study

E. Winzeler, D. Fidock, M. Phillips, 2018, The Lancet. Infectious diseases.

The mammalian oral toxicity of fluoroacetamide

M. Phillips, A. Worden, 1957 .

TOXICITY OF FLUOROACETAMIDE

M. Phillips, A. Worden, 1956 .

Assay of Cation-Active Antiseptics

M. Phillips, 1947, Nature.

Novel Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Anti-malarial Activity in the Mouse Model*

Bradley I. Coleman, E. Goldsmith, R. Barker, 2010, The Journal of Biological Chemistry.

Medicinal Chemistry Case History: Discovery of the Dihydroorate Dehydrogenase Inhibitor DSM265 as an Antimalarial Drug Candidate

P. Rathod, M. Phillips, S. Charman, 2017 .

Analysis of flavin oxidation and electron-transfer inhibition in Plasmodium falciparum dihydroorotate dehydrogenase.

P. Rathod, N. A. Malmquist, M. Phillips, 2008, Biochemistry.

Detergent-dependent Kinetics of Truncated Plasmodium falciparumDihydroorotate Dehydrogenase*

J. Baldwin, N. A. Malmquist, M. Phillips, 2007, Journal of Biological Chemistry.

SAR Based Optimization of a 4-Quinoline Carboxylic Acid Analog with Potent Anti-Viral Activity.

M. Roth, M. Phillips, B. Fontoura, 2013, ACS medicinal chemistry letters.

Cellular evaluation of synthesized insulin/transferrin bioconjugates for oral insulin delivery using intelligent complexation hydrogels.

Nicholas A Peppas, M. Phillips, N. Peppas, 2010, Macromolecular bioscience.

Genetic Validation of Trypanosoma brucei Glutathione Synthetase as an Essential Enzyme

M. Phillips, Suong T. T. Nguyen, Chelsea Pratt, 2014, Eukaryotic Cell.

Genetic validation of Trypanosoma brucei glutathione synthetase as an 1 essential enzyme 2 3

M. Phillips, Suong T. T. Nguyen, Chelsea Pratt, 2014 .

Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog

N. Grishin, L. Kinch, M. Phillips, 2016, eLife.

Identification of New Human Malaria Parasite Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors by Pharmacophore and Structure-Based Virtual Screening

Margaret A. Phillips, Kelly Chibale, Sergio Wittlin, 2016, J. Chem. Inf. Model..

Synthesis and evaluation of analogs of 5'-(((Z)-4-amino-2-butenyl)methylamino)-5'-deoxyadenosine (MDL 73811, or AbeAdo) - An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity.

T. E. Richardson, M. Phillips, M. Peel, 2017, Bioorganic & medicinal chemistry.

Fluoroacetamide as a rodenticide

M. Phillips, C. Chapman, 1955 .

X-ray structure of ornithine decarboxylase from Trypanosoma brucei: the native structure and the structure in complex with alpha-difluoromethylornithine.

N. Grishin, E. Goldsmith, A. Osterman, 1999, Biochemistry.

Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265.

Pradipsinh K Rathod, Xiaoyi Deng, P. Rathod, 2018, ACS infectious diseases.

Allosteric Activation of Trypanosomatid Deoxyhypusine Synthase by a Catalytically Dead Paralog

A. Fairlamb, M. Phillips, S. Wyllie, 2013, The Journal of Biological Chemistry.

Lead optimization of a pyrrole-based dihydroorotate dehydrogenase inhibitor series for the treatment of Malaria.

David M. Shackleford, P. Rathod, John White, 2020, Journal of medicinal chemistry.

The subunit interfaces of oligomeric enzymes are conserved to a similar extent to the overall protein sequences

N. Grishin, M. Phillips, N V Grishin, 1994, Protein science : a publication of the Protein Society.

Improved Synthesis of MDL 73811 – A Potent AdoMetDC Inhibitor and Anti-Trypanosomal Compound

M. Phillips, C. Cosner, J. D. De Brabander, 2016, Synthesis.

Guanidine derivatives restore activity to carboxypeptidase lacking arginine‐127

W. Rutter, M. Phillips, L. Hedstrom, 1992, Protein science : a publication of the Protein Society.

The thrH Gene Product of Pseudomonas aeruginosa Is a Dual Activity Enzyme with a Novel Phosphoserine:Homoserine Phosphotransferase Activity*

M. Phillips, Kun Yang, Hong Zhang, 2004, Journal of Biological Chemistry.

Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with novel Inhibitor Genz667348

M. Phillips, M. Booker, Xiao-Yi Deng, 2010 .

Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series.

David M. Shackleford, E. Winzeler, P. Rathod, 2021, Journal of medicinal chemistry.

Malarial dihydroorotate dehydrogenase: substrate and inhibitor specificity.

P. Rathod, N. A. Malmquist, M. Phillips, 2002 .

Paramecium bursaria Chlorella Virus-1 Encodes an Unusual Arginine Decarboxylase That Is a Close Homolog of Eukaryotic Ornithine Decarboxylases*

N. Grishin, J. V. Van Etten, J. Baldwin, 2004, Journal of Biological Chemistry.

Identification and assay of allosteric regulators of S-adenosylmethionine decarboxylase.

L. Kinch, M. Phillips, Erin K. Willert, 2011, Methods in molecular biology.

Single-turnover kinetic analysis of Trypanosoma cruzi S-adenosylmethionine decarboxylase.

L. Kinch, M. Phillips, 2000, Biochemistry.

Repurposed dihydroorotate dehydrogenase inhibitors with efficacy against drug-resistant Acinetobacter baumannii

P. Rathod, M. Phillips, B. Posner, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Neofunctionalization of S-adenosylmethionine decarboxylase into pyruvoyl-dependent L-ornithine and L-arginine decarboxylases is widespread in bacteria and archaea

M. Phillips, A. Michael, Jue Liang, 2023, The Journal of biological chemistry.

Discovery of Potent and Selective Inhibitors of Trypanosoma brucei Ornithine Decarboxylase*

M. Phillips, A. Shelat, R. Guy, 2010, The Journal of Biological Chemistry.

X-ray Structure Determination of Trypanosoma brucei Ornithine Decarboxylase Bound to d-Ornithine and to G418

E. Goldsmith, M. Phillips, L. Jackson, 2003, Journal of Biological Chemistry.

User Acceptability Patterns for Mefloquine and Doxycycline Malaria Chemoprophylaxis.

M. Phillips, Kåss, R. Kass, 1996, Journal of travel medicine.

Knockout of HD domain 5’-nucleotidase in T. brucei triggers cell death linked to DNA damage and downregulation of glutamine uptake

M. Phillips, Michael A. Pontikos, Noelle S. Williams, 2023, bioRxiv.

Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease

F. Supek, M. Phillips, M. Arkin, 2015, PLoS pathogens.

Putrescine activation of Trypanosoma cruzi S-adenosylmethionine decarboxylase.

L. Kinch, M. Phillips, T. Clyne, 2002, Biochemistry.

Evolution of substrate specificity within a diverse family of beta/alpha-barrel-fold basic amino acid decarboxylases: X-ray structure determination of enzymes with specificity for L-arginine and carboxynorspermidine.

Xiaoyi Deng, E. Goldsmith, M. Phillips, 2010, The Journal of biological chemistry.

Crystallization and preliminary X‐ray studies of ornithine decarboxylase from Trypanosoma brucei

N. Grishin, E. Goldsmith, A. Osterman, 1996, Proteins.

Structural and mechanistic studies of Trypanosoma brucei ornithine decarboxylase

M. Phillips, 2000 .

CRYSTAL STRUCTURE OF TRYPANOSOMA BRUCEI ORNITHINE DECARBOXYLASE

N. Grishin, E. Goldsmith, A. Osterman, 1999 .

Lysine-69 plays a key role in catalysis by ornithine decarboxylase through acceleration of the Schiff base formation, decarboxylation, and product release steps.

A. Osterman, M. Phillips, H. Brooks, 1999, Biochemistry.

Atovaquone Tolerance in Plasmodium falciparum Parasites Selected for High-Level Resistance to a Dihydroorotate Dehydrogenase Inhibitor

Jennifer L. Guler, P. Rathod, John White, 2014, Antimicrobial Agents and Chemotherapy.

The X-ray structure of Plasmodium falciparum dihydroorotate dehydrogenase bound to a potent and selective N-phenylbenzamide inhibitor reveals novel binding-site interactions.

P. Rathod, M. Phillips, D. Matthews, 2015, Acta crystallographica. Section F, Structural biology communications.

The translation initiation site of recombinant Trypanosoma brucei ornithine decarboxylase varies with different promoters.

M. Phillips, C. Wang, S. Craig, 1992, Molecular and biochemical parasitology.

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

Farah El Mazouni, T. Laird, P. Rathod, 2015, Science Translational Medicine.

X-ray Structure Determination of Trypanosoma brucei Ornithine Decarboxylase Bound to D-Ornithine and to G418 INSIGHTS INTO SUBSTRATE BINDING AND ODC CONFORMATIONAL FLEXIBILITY*

E. Goldsmith, M. Phillips, L. Jackson, 2003 .

Characterization of the reaction mechanism for Trypanosoma brucei ornithine decarboxylase by multiwavelength stopped-flow spectroscopy.

M. Phillips, H. Brooks, 1997, Biochemistry.

Carbon-13 isotope effect studies of Trypanosoma brucei ornithine decarboxylase.

A. Osterman, M. Phillips, H. Brooks, 1998, Biochemistry.

Circular dichroism assay for decarboxylation of optically pure amino acids: application to ornithine decarboxylase.

M. Phillips, H. Brooks, 1996, Analytical biochemistry.

Fast-Killing Tyrosine Amide ((S)-SW228703) with Blood- and Liver-Stage Antimalarial Activity Associated with the Cyclic Amine Resistance Locus (PfCARL).

E. Winzeler, M. Phillips, F. Gamo, 2023, ACS Infectious Diseases.