C. Lukas

发表

RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins

J. Ellenberg, R. Pepperkok, D. Durocher, 2009, Cell.

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

T. Ørntoft, J. Nesland, J. Bartek, 2005, Nature.

Mammalian cell cycle checkpoints: signalling pathways and their organization in space and time.

J. Bartek, J. Lukas, C. Lukas, 2004, DNA repair.

RNF8 Ubiquitylates Histones at DNA Double-Strand Breaks and Promotes Assembly of Repair Proteins

Jiri Bartek, Helene Faustrup, Fredrik Melander, 2007, Cell.

Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

Jiri Bartek, Risa Kitagawa, Fredrik Melander, 2006, The Journal of cell biology.

Rapid destruction of human Cdc25A in response to DNA damage.

N. Mailand, J. Bartek, J. Lukas, 2000, Science.

p16INK4a, but not constitutively active pRb, can impose a sustained G1 arrest: molecular mechanisms and implications for oncogenesis

J. Bartek, J. Lukas, C. Lukas, 1999, Oncogene.

Immunohistochemical analysis of the D-type cyclin-dependent kinases Cdk4 and Cdk6, using a series of monoclonal antibodies.

J. Bartek, J. Lukas, C. Lukas, 1999, Hybridoma.

Nucleoporin NUP153 guards genome integrity by promoting nuclear import of 53BP1

J. Ellenberg, R. Pepperkok, B. Neumann, 2011, Cell Death and Differentiation.

DVC1 (C1orf124) is a DNA damage–targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks

S. V. Nielsen, R. Hartmann-Petersen, N. Mailand, 2012, Nature Structural &Molecular Biology.

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

Jiri Bartek, Ali Jazayeri, Stephen P. Jackson, 2006, Nature Cell Biology.

Human CtIP promotes DNA end resection

Jiri Bartek, Stephen P. Jackson, J. Bartek, 2007, Nature.

TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes

Jiri Bartek, Darren Saunders, Beate Neumann, 2014, Cell.

A Conserved Cyclin-Binding Domain Determines Functional Interplay between Anaphase-Promoting Complex–Cdh1 and Cyclin A-Cdk2 during Cell Cycle Progression

J. Peters, J. Bartek, J. Lukas, 2001, Molecular and Cellular Biology.

Mutations in ELANE and COH1 ( VPS13B ) Genes Cause Severe Neutropenia in a Patient with Cohen Syndrome

C. Lukas, B. Xin, Heng Wang, 2015 .

Advances in Brief DNA Damage-activated Kinase Chk 2 Is Independent of Proliferation or Differentiation Yet Correlates with Tissue Biology 1

N. Mailand, J. Bartek, J. Lukas, 2001 .

Stabilization of chromatin topology safeguards genome integrity

G. Karemore, J. Lukas, C. Lukas, 2019, Nature.

Deep Visual Proteomics defines single-cell identity and heterogeneity

A. Brunner, E. Lengyel, E. Lundberg, 2022, Nature Biotechnology.

19-Induced Dendritic Cell Migration Receptor 1 in C-C Motif Chemokine Ligand Novel Regulator of Sphingosine 1-Phosphate Four and a Half LIM Domain Protein 2 Is a

C. Lukas, P. Knolle, T. Quast, 2010 .

Deregulation of the RB pathway in human testicular germ cell tumours

J. Bartek, J. Lukas, C. Lukas, 2003, The Journal of pathology.

ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA

N. Mailand, S. Bekker-Jensen, D. H. Larsen, 2013, Cell.

Integrating Proteomic and Functional Genomic Technologies in Discovery-driven Translational Breast Cancer Research*

Lars Bolund, Jiri Bartek, Peter Roepstorff, 2003, Molecular & Cellular Proteomics.

The regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome

C. Lukas, I. Ahel, M. L. Nielsen, 2021, Nature Communications.

Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex

Jiri Bartek, Jan-Michael Peters, Claus Storgaard Sørensen, 1999, Nature.

Homozygous deficiency of ubiquitin-ligase ring-finger protein RNF168 mimics the radiosensitivity syndrome of ataxia-telangiectasia

C. Doil, J. Bartek, J. Lukas, 2011, Cell Death and Differentiation.

Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway

Y. Shiloh, S. Bekker-Jensen, J. Bartek, 2006, Nature Cell Biology.

Mdc1 couples DNA double‐strand break recognition by Nbs1 with its H2AX‐dependent chromatin retention

Jiri Bartek, Michal Goldberg, Fredrik Melander, 2004, The EMBO journal.

The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage

P. Ménard, D. H. Larsen, J. Bartek, 2010, The Journal of cell biology.

Checking on DNA damage in S phase

Jiri Bartek, J. Bartek, J. Lukas, 2004, Nature Reviews Molecular Cell Biology.

Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability

L. Scorrano, Z. Livneh, J. Bartek, 2017, Genome Biology.

Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks

J. Lukas, C. Lukas, Fena Ochs, 2016, Molecular cell.

53BP1 fosters fidelity of homology-directed DNA repair

J. Lukas, C. Lukas, Kumar Somyajit, 2016, Nature Structural &Molecular Biology.

LEDGF (p75) promotes DNA-end resection and homologous recombination

P. Sorensen, J. Bartek, J. Lukas, 2012, Nature Structural &Molecular Biology.

Ectopic expression of RNF168 and 53BP1 increases mutagenic but not physiological non-homologous end joining

J. Lukas, C. Lukas, A. Nussenzweig, 2015, Nucleic acids research.

Ubiquitin-activating enzyme UBA1 is required for cellular response to DNA damage

J. Bartek, J. Lukas, C. Lukas, 2012, Cell cycle.

The NBS1–Treacle complex controls ribosomal RNA transcription in response to DNA damage

S. Smerdon, D. H. Larsen, J. Lukas, 2014, Nature Cell Biology.

ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA

N. Mailand, S. Bekker-Jensen, D. H. Larsen, 2013, Cell.

TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes

B. Neumann, J. Hériché, N. Mailand, 2012, Cell.

DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology.

N. Mailand, J. Bartek, J. Lukas, 2001, Cancer research.

ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA

N. Mailand, S. Bekker-Jensen, D. H. Larsen, 2013, Cell.

Nonperiodic Activity of the Human Anaphase-Promoting Complex–Cdh1 Ubiquitin Ligase Results in Continuous DNA Synthesis Uncoupled from Mitosis

J. Peters, J. Bartek, J. Lukas, 2000, Molecular and Cellular Biology.

HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes

N. Mailand, S. Bekker-Jensen, J. Bartek, 2010, Nature Cell Biology.

Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage

J. Bartek, J. Lukas, C. Lukas, 2003, Nature Cell Biology.

Inhibition of Chk1 by CEP-3891 Accelerates Mitotic Nuclear Fragmentation in Response to Ionizing Radiation

J. Bartek, J. Lukas, C. Lukas, 2004, Cancer Research.

Inhibition of Chk 1 by CEP-3891 Accelerates Mitotic Nuclear Fragmentation in Response to Ionizing Radiation

J. Bartek, J. Lukas, C. Lukas, 2004 .

Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1

S. Bekker-Jensen, J. Bartek, J. Lukas, 2005, The Journal of cell biology.

53BP1 nuclear bodies enforce replication timing at under-replicated DNA to limit heritable DNA damage

Julian Spies, J. Lukas, C. Lukas, 2019, Nature Cell Biology.

53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

B. Neumann, C. Doil, S. Bekker-Jensen, 2011, Nature Cell Biology.

Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation

N. Mailand, J. Bartek, J. Lukas, 2002, Nature Cell Biology.

More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance

J. Bartek, J. Lukas, C. Lukas, 2011, Nature Cell Biology.

Profiling DNA damage response following mitotic perturbations

J. Ellenberg, R. Pepperkok, G. Karemore, 2016, Nature Communications.

A Conserved Cyclin-Binding Domain Determines Functional Interplay between Anaphase-Promoting Complex–Cdh1 and Cyclin A-Cdk2 during Cell Cycle Progression

J. Peters, J. Bartek, J. Lukas, 2001, Molecular and Cellular Biology.

Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks

N. Mailand, S. Bekker-Jensen, J. Lukas, 2012, The Journal of cell biology.

Human RNF 169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks

N. Mailand, S. Bekker-Jensen, J. Lukas, 2022 .

Imaging of protein movement induced by chromosomal breakage: tiny ‘local’ lesions pose great ‘global’ challenges

J. Bartek, J. Lukas, C. Lukas, 2005, Chromosoma.

53BP1 nuclear bodies enforce replication timing at under-replicated DNA to limit heritable DNA damage

Julian Spies, J. Lukas, C. Lukas, 2019, Nature Cell Biology.

The Deubiquitylating Enzyme USP44 Counteracts the DNA Double-strand Break Response Mediated by the RNF8 and RNF168 Ubiquitin Ligases*

N. Mailand, S. Bekker-Jensen, C. Lukas, 2013, Journal of Biological Chemistry.

Centrosome-associated Chk1 prevents premature activation of cyclin-B–Cdk1 kinase

N. Mailand, J. Bartek, J. Lukas, 2004, Nature Cell Biology.

Year : 2010 The chromatin-remodeling factor CHD 4 coordinates signaling and repair after DNA damage

P. Ménard, D. H. Larsen, J. Bartek, 2010 .

Claspin Operates Downstream of TopBP1 To Direct ATR Signaling towards Chk1 Activation

N. Mailand, S. Bekker-Jensen, J. Bartek, 2006, Molecular and Cellular Biology.

Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway

M. Protopopova, J. Bartek, J. Lukas, 2001, Oncogene.

The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator

S. Smerdon, D. H. Larsen, J. Lukas, 2012, Nucleic acids research.

AI-driven Deep Visual Proteomics defines cell identity and heterogeneity

M. Mann, E. Lundberg, P. Horváth, 2021, bioRxiv.

The chromatin scaffold protein SAFB1 renders chromatin permissive for DNA damage signaling.

B. Blagoev, J. Bartek, J. Lukas, 2013, Molecular cell.

The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage

D. H. Larsen, J. Bartek, J. Lukas, 2010, The Journal of cell biology.

Shielding Broken DNA for a Quick Fix

J. Lukas, C. Lukas, Jiri Lukas, 2013, Science.

Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

J. Bartek, J. Lukas, C. Lukas, 2006, The Journal of cell biology.

The Deubiquitylating Enzyme USP44 Counteracts the DNA Double-strand Break Response Mediated by the RNF8 and RNF168 Ubiquitin Ligases*

C. Lukas, Anna Mosbech, Simon Bekker-Jensen, 2013, The Journal of Biological Chemistry.