J. Nettles

发表

"Bayes Affinity Fingerprints" Improve Retrieval Rates in Virtual Screening and Define Orthogonal Bioactivity Space: When Are Multitarget Drugs a Feasible Concept?

Andreas Bender, Meir Glick, Jeremy L. Jenkins, 2006, J. Chem. Inf. Model..

Bridging chemical and biological space: "target fishing" using 2D and 3D molecular descriptors.

Z. Deng, A. Bender, J. Jenkins, 2006, Journal of medicinal chemistry.

The tubulin binding mode of microtubule stabilizing agents studied by electron crystallography.

K. Downing, J. Nettles, 2009, Topics in current chemistry.

Conceptions of Potency, Purity, and Synergy-by-Design: Toward Developing a Sowa Rigpa Medical Theory-based Approach to Pharmaceutical Research

J. Nettles, Tawni Tidwell, Tawni L Tidwell, 2019 .

Approaches to hepatitis C treatment and cure using NS5A inhibitors

Richard A. Stanton, J. Nettles, R. Schinazi, 2014, Infection and Drug Resistance.

Understanding False Positives in Reporter Gene Assays: in Silico Chemogenomics Approaches To Prioritize Cell-Based HTS Data

Andreas Bender, Meir Glick, Jeremy L. Jenkins, 2007, J. Chem. Inf. Model..

Richard A. Stanton, J. Nettles, R. Schinazi, 2015, Journal of Molecular Modeling.

Selection and Characterization of HIV-1 with a Novel S68 Deletion in Reverse Transcriptase

Richard A. Stanton, J. Nettles, R. Schinazi, 2011, Antimicrobial Agents and Chemotherapy.

Asymmetric Binding to NS5A by Daclatasvir (BMS-790052) and Analogs Suggests Two Novel Modes of HCV Inhibition

Richard A. Stanton, J. Nettles, R. Schinazi, 2014, Journal of medicinal chemistry.

Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of β-tubulin (Asp26Glu) and less stable microtubules

J. Snyder, J. Nettles, F. Loganzo, 2006, Molecular Cancer Therapeutics.

Substrates and Inhibitors of SAMHD1

J. Nettles, R. Schinazi, Baek Kim, 2017, PloS one.

Substrate mimicry: HIV-1 reverse transcriptase recognizes 6-modified-3′-azido-2′,3′-dideoxyguanosine-5′-triphosphates as adenosine analogs

Richard A. Stanton, J. Nettles, J. Mellors, 2011, Nucleic acids research.

Comparative analysis of in vitro processivity of HIV-1 reverse transcriptases containing mutations 65R, 74V, 184V and 65R+74V.

J. Nettles, R. Schinazi, P. L. Sharma, 2009, Antiviral research.

The Binding Mode of Epothilone A on α,ß-Tubulin by Electron Crystallography

Ben Cornett, James P. Snyder, Huilin Li, 2004, Science.

Microtubule-interacting drugs for cancer treatment.

J. Snyder, J. Nettles, Jun Zhou, 2003, Trends in pharmacological sciences.

Design, synthesis and evaluation of novel anti-HCV molecules that deliver intracellularly three highly potent NS5A inhibitors.

Richard A. Stanton, J. Nettles, R. Schinazi, 2015, Bioorganic & medicinal chemistry letters.

Drugs that target dynamic microtubules: A new molecular perspective

Richard A. Stanton, J. Nettles, K. Gernert, 2011, Medicinal research reviews.

The oxetane ring in taxol.

J. Snyder, J. Nettles, B. Cornett, 2000, The Journal of organic chemistry.

The binding conformation of Taxol in β-tubulin: A model based on electron crystallographic density

J. Snyder, E. Nogales, K. Downing, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Polyoxometalate HIV-1 protease inhibitors. A new mode of protease inhibition.

R F Schinazi, J. Snyder, Neysa Nevins, 2001, Journal of the American Chemical Society.

Synthesis, antiviral activity, cytotoxicity and cellular pharmacology of l-3'-azido-2',3'-dideoxypurine nucleosides.

J. Nettles, J. Mellors, R. Schinazi, 2011, European journal of medicinal chemistry.

Approaches for the development of antiviral compounds: the case of hepatitis C virus.

J. Nettles, R. Schinazi, J. Lennerstrand, 2009, Handbook of experimental pharmacology.

Farnesyl transferase inhibitors impair chromosomal maintenance in cell lines and human tumors by compromising CENP-E and CENP-F function

J. Snyder, A. Marcus, F. Khuri, 2007, Molecular Cancer Therapeutics.

Combretastatin-like chalcones as inhibitors of microtubule polymerisation. Part 2: Structure-based discovery of alpha-aryl chalcones.

J. Snyder, J. Nettles, B. Greedy, 2009, Bioorganic & medicinal chemistry.

Rational design of the microtubule-targeting anti-breast cancer drug EM015.

J. Nettles, Meenakshi Gupta, R. Chandra, 2006, Cancer research.

Geopharmaceuticals of Himalayan Sowa Rigpa medicine: Ethnopharmacological uses, mineral diversity, chemical identification and current utilization in Bhutan.

J. Nettles, S. Craig, P. Wangchuk, 2018, Journal of ethnopharmacology.

“Plate Cherry Picking”: A Novel Semi-Sequential Screening Paradigm for Cheaper, Faster, Information-Rich Compound Selection

Andreas Bender, Meir Glick, Christian N Parker, 2007, Journal of biomolecular screening.

Variation of Human Immunodeficiency Virus Type-1 Reverse Transcriptase within the Simian Immunodeficiency Virus Genome of RT-SHIV

Richard A. Stanton, N. Pedersen, J. Nettles, 2014, PloS one.

Flexible 3D pharmacophores as descriptors of dynamic biological space.

Andreas Bender, Meir Glick, Alex M Clark, 2007, Journal of molecular graphics & modelling.

Enrichment of High-Throughput Screening Data with Increasing Levels of Noise Using Support Vector Machines, Recursive Partitioning, and Laplacian-Modified Naive Bayesian Classifiers

Meir Glick, Jeremy L. Jenkins, John W. Davies, 2006, J. Chem. Inf. Model..

Synthesis and evaluation of non-dimeric HCV NS5A inhibitors.

J. Nettles, R. Schinazi, F. Amblard, 2013, Bioorganic & medicinal chemistry letters.