V. Saudek

发表

Solution structure of a neurotrophic ligand bound to FKBP12 and its effects on protein dynamics.

C. Sich, S. Improta, D. J. Cowley, 2000, European journal of biochemistry.

The human lipodystrophy protein seipin is an ER membrane adaptor for the adipogenic PA phosphatase lipin 1.

S. O’Rahilly, V. Saudek, D. Ito, 2013, Molecular metabolism.

Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations.

Philippe Froguel, David Meyre, Arnold Munnich, 2009, American journal of human genetics.

Gradient-Tailored Water Suppression for 1H-15N HSQC Experiments Optimized to Retain Full Sensitivity

Vladimir Sklenar, V. Saudek, V. Sklenar, 1993 .

Genome-wide scan and fine-mapping of rare nonsynonymous associations implicates intracellular lipolysis genes in fat distribution and cardio-metabolic risk

M. McCarthy, Satish Patel, J. Perry, 2018, bioRxiv.

GEI-8, a Homologue of Vertebrate Nuclear Receptor Corepressor NCoR/SMRT, Regulates Gonad Development and Neuronal Functions in Caenorhabditis elegans

V. Saudek, M. Krause, P. Mikolas, 2013, PloS one.

Structure activity relationship by NMR and by computer: a comparative study.

Nicolas Froloff, Finton Sirockin, Martin Karplus, 2002, Journal of the American Chemical Society.

Correlation between the sequence‐length distribution and structure of statistical copolymers of L‐valine and γ‐benzyl‐L‐glutamate

V. Saudek, J. Stejskal, P. Kratochvíl, 1987 .

The solution structure of a leucine-zipper motif peptide.

T. Gibson, A. Pastore, V. Saudek, 1991, Protein engineering.

Three-dimensional structure of echistatin, the smallest active RGD protein.

V. Saudek, R. Atkinson, J. Pelton, 1991, Biochemistry.

Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression

V. Saudek, J. Goodall, Changxing Wu, 2010, Proceedings of the National Academy of Sciences.

Dual binding motifs underpin the hierarchical association of perilipins1–3 with lipid droplets

V. Saudek, M. Mimmack, A. Thiam, 2019, Molecular biology of the cell.

Obesity-associated gene TMEM18 has a role in the central control of appetite and body weight regulation

S. O’Rahilly, V. Saudek, G. Yeo, 2017, Proceedings of the National Academy of Sciences.

Acute intermittent porphyria – impact of mutations found in the hydroxymethylbilane synthase gene on biochemical and enzymatic protein properties

V. Saudek, P. Martásek, M. Hrdinka, 2009, The FEBS journal.

A new mutation within the porphobilinogen deaminase gene leading to a truncated protein as a cause of acute intermittent porphyria in an extended Indian family.

V. Saudek, I. Verma, J. Zeman, 2007, Folia biologica.

Clinical and Molecular Characterization of a Novel PLIN1 Frameshift Mutation Identified in Patients With Familial Partial Lipodystrophy

S. O’Rahilly, V. Saudek, I. Barroso, 2014, Diabetes.

Identification of Rare Loss-of-Function Genetic Variation Regulating Body Fat Distribution

M. McCarthy, Satish Patel, C. A. Glastonbury, 2021, The Journal of clinical endocrinology and metabolism.

Human Frame Shift Mutations Affecting the Carboxyl Terminus of Perilipin Increase Lipolysis by Failing to Sequester the Adipose Triglyceride Lipase (ATGL) Coactivator AB-hydrolase-containing 5 (ABHD5)*

S. O’Rahilly, V. Saudek, S. Gandotra, 2011, The Journal of Biological Chemistry.

Deletion of V335 from the L2 domain of the insulin receptor results in a conformationally abnormal receptor that is unable to bind insulin and causes Donohue's syndrome in a human subject.

S. Gammeltoft, S. O’Rahilly, K. Siddle, 2003, Endocrinology.

Perilipins 2 and 3 lack a carboxy-terminal domain present in perilipin 1 involved in sequestering ABHD5 and suppressing basal lipolysis

V. Saudek, D. Savage, Wei Yang, 2014, Proceedings of the National Academy of Sciences.

PCYT1A Regulates Phosphatidylcholine Homeostasis from the Inner Nuclear Membrane in Response to Membrane Stored Curvature Elastic Stress

Marcus K. Dymond, V. Saudek, R. Hardie, 2018, Developmental cell.

Lichen sclerosus et atrophicus-like skin lesions in a patient carrying a novel hydroxymethylbilane synthase mutation.

L. French, V. Saudek, X. Schneider-Yin, 2010, Blood cells, molecules & diseases.

Cystinosin, MPDU1, SWEETs and KDELR Belong to a Well-Defined Protein Family with Putative Function of Cargo Receptors Involved in Vesicle Trafficking

V. Saudek, 2012, PloS one.

An echistatin C-terminal peptide activates GPIIbIIIa binding to fibrinogen, fibronectin, vitronectin and collagen type I and type IV.

A. Bitonti, P. Wright, V. Saudek, 1993, The Biochemical journal.

The nematode homologue of Mediator complex subunit 28, F28F8.5, is a critical regulator of C. elegans development

V. Saudek, A. Benda, M. Krause, 2017, PeerJ.

13C n.m.r. study of the structure of poly(aspartic acid)

V. Saudek, H. Pivcová, H. Drobnik, 1982 .

Nmr study of poly(aspartic acid). I. α‐ and β‐Peptide bonds in poly(aspartic acid) prepared by thermal polycondensation

V. Saudek, J. Vlasák, J. Drobník, 1981 .

Identification and description of alpha-helical regions in horse muscle acylphosphatase by 1H nuclear magnetic resonance spectroscopy.

R. J. Williams, V. Saudek, G. Ramponi, 1989, Journal of molecular biology.

Enzyme immobilization techniques on poly(glycidyl methacrylate‐co‐ethylene dimethacrylate) carrier with penicillin amidase as model

V. Saudek, J. Kálal, M. Bárta, 1979, Biotechnology and bioengineering.

Echistatin: the refined structure of a disintegrin in solution by 1H NMR and restrained molecular dynamics.

V. Saudek, R. Atkinson, J. Pelton, 2009, International journal of peptide and protein research.

The secondary structure of echistatin from 1H-NMR, circular-dichroism and Raman spectroscopy.

V. Saudek, R. Atkinson, P. Lepage, 1991, European journal of biochemistry.

Potential dual function of PQ-loop proteins such as cystinosin

V. Saudek, 2017, The Journal of Biological Chemistry.

Poly(N5-hydroxyalkylglutamines). IV. Enzymatic degradation of n5-(2-hydroxyethyl)-L-glutamine homopolymers and copolymers

V. Saudek, F. Rypáček, J. Drobník, 1989 .

High molecular weight derivative of trypsin-kallikrein inhibitor for potential medical use, 1. Preparation and characterization†

V. Saudek, D. Čechová, J. Drobník, 1982 .

Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions

V. Saudek, V. Sklenar, M. Piotto, 1992, Journal of biomolecular NMR.

Sequence Identification and Characterization of Human Carnosinase and a Closely Related Non-specific Dipeptidase*

D. Duverger, N. Cairns, D. J. Cowley, 2003, The Journal of Biological Chemistry.

Immobilization of DNA on poly(glycidyl methacrylate-co-ethylene dimethacrylate), bead cellulose and sepharose

V. Saudek, J. Kálal, J. Drobník, 1980 .

Use of potentiometric titration for determination of α‐ and ω‐peptide bonds in poly(aspartic acid) and poly(glutamic acid)

V. Saudek, 1981 .

Reaction of Pt(II) antitumor drugs with selected nucleophiles III. cis - [Pt(NH3)2Cl2] and diamminemalonato-Pt(II) complexes compared in the reaction with glycine and l-histidine

V. Saudek, J. Drobník, H. Pivcová, 1985 .

The reaction of Pt-antitumor drugs with selected nucleophiles. I. The reaction of cis-[Pt(NH3)2Cl2] with glycine.

V. Saudek, J. Drobník, H. Pivcová, 1985, Journal of inorganic biochemistry.

Hepatoerythropoietic Porphyria Caused by a Novel Homoallelic Mutation in Uroporphyrinogen Decarboxylase Gene in Egyptian Patients.

V. Saudek, E. Richard, I. Mikula, 2015, Folia biologica.

The reaction of Pt-antitumor drugs with selected nucleophiles. II. Preparation and characterization of coordination compounds of Pt(II) and L-histidine.

V. Saudek, J. Drobník, H. Pivcová, 1985, Journal of Inorganic Biochemistry.

The activation of hydroxy groups of carriers with 4-nitrophenyl and N-hydroxysuccinimidyl chloroformates.

V. Saudek, J. Labský, F. Švec, 1982, Biotechnology and bioengineering.

Stimulation of cGMP-dependent protein kinase Iα by a peptide from its own sequence

V. Saudek, R. Atkinson, J. Pelton, 1994 .

Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23

V. Saudek, Changxing Wu, L. McNeill, 2010 .

The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase

Chris P. Ponting, Christopher J. Schofield, Patrik Rorsman, 2007, Science.

PCYT1A Regulates Phosphatidylcholine Homeostasis from the Inner Nuclear Membrane in Response to Membrane Stored Curvature Elastic Stress

Marcus K. Dymond, V. Saudek, R. Hardie, 2018, Developmental cell.

SKIP is an indispensable factor for Caenorhabditis elegans development

V. Saudek, J. E. Rall, D. Housa, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Loss and gain of function experiments implicate TMEM18 as a mediator of the strong association between genetic variants at human Chromosome 2p25.3 and obesity

S. O’Rahilly, V. Saudek, G. Yeo, 2017, bioRxiv.

BIR-1, a Caenorhabditis elegans homologue of Survivin, regulates transcription and development

V. Saudek, J. Piatigorsky, J. E. Rall, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Human biallelic MFN2 mutations induce mitochondrial dysfunction, upper body adipose hyperplasia, and suppression of leptin expression

T. Hansen, O. Pedersen, S. O’Rahilly, 2017, eLife.

Mutations disrupting the Kennedy phosphatidylcholine pathway in humans with congenital lipodystrophy and fatty liver disease

S. O’Rahilly, Yali Xue, V. Saudek, 2014, Proceedings of the National Academy of Sciences.

Structure of neuropeptide Y dimer in solution.

D. J. Cowley, V. Saudek, J. Hoflack, 1992, European journal of biochemistry.

Sequence-specific 1H NMR assignment and secondary structure of neuropeptide Y in aqueous solution.

V. Saudek, J. Pelton, John T. Pelton, 1990, Biochemistry.

Prevalence of Loss-of-Function FTO Mutations in Lean and Obese Individuals

S. O’Rahilly, F. Horber, B. Balkau, 2009, Diabetes.

Identification of rare loss of function variation regulating body fat distribution

J. Perry, C. A. Glastonbury, K. Small, 2021, medRxiv.

Three-dimensional structure of acylphosphatase. Refinement and structure analysis.

R J Williams, R. J. Williams, V. Saudek, 1992, Journal of molecular biology.

Hypomorphism in human NSMCE 2 linked to primordial dwarfism and insulin resistance

S. O’Rahilly, V. Saudek, I. Barroso, 2014 .

1H NMR and circular dichroism studies of the N-terminal domain of cyclic GMP dependent protein kinase: a leucine/isoleucine zipper.

V. Saudek, R. Atkinson, J. Pelton, 1991, Biochemistry.

GDF15: A Hormone Conveying Somatic Distress to the Brain

S. O’Rahilly, V. Saudek, S. Lockhart, 2020, Endocrine reviews.

Hypomorphism in human NSMCE2 linked to primordial dwarfism and insulin resistance.

S. O’Rahilly, V. Saudek, I. Barroso, 2014, The Journal of clinical investigation.

The metabolic syndrome- associated small G protein ARL15 plays a role in adipocyte differentiation and adiponectin secretion

S. O’Rahilly, V. Saudek, I. Barroso, 2017, Scientific Reports.

Mapping the active site of factor Xa by selective inhibitors: An NMR and MD study

F. Fraternali, V. Saudek, P. Šafář, 1998, Proteins.

Phenotypic characterization of Adig null mice suggests roles for adipogenin in the regulation of fat mass accrual and leptin secretion

S. O’Rahilly, V. Saudek, D. Savage, 2021, Cell reports.

Conformation of poly(glutamic acid) and of poly(aspartic acid) in the solid state. X-ray diffraction, infra-red and 13C cross-polarization/magic angle spinning nuclear magnetic resonance spectroscopic study

V. Saudek, P. Schmidt, F. Lauprêtre, 1987 .

Topological mirror images in protein structure computation: An underestimated problem

R J Williams, V. Saudek, R. Atkinson, 1991, Proteins.

Identification and description of beta-structure in horse muscle acylphosphatase by nuclear magnetic resonance spectroscopy.

R. J. Williams, V. Saudek, G. Ramponi, 1989, Journal of molecular biology.

Conserved Amphipathic Helices Mediate Lipid Droplet Targeting of Perilipins 1–3

V. Saudek, M. Mimmack, A. Thiam, 2016, The Journal of Biological Chemistry.

The sequence-specific assignment of the 1H-NMR spectrum of an enzyme, horse-muscle acylphosphatase.

R. J. Williams, V. Saudek, G. Ramponi, 1989, European journal of biochemistry.

The structure and properties of horse muscle acylphosphatase in solution Mobility of antigenic and active site regions

V. Saudek, G. Ramponi, Robert J.P. Williams, 1989, FEBS letters.

FTO is necessary for the induction of leptin resistance by high-fat feeding

S. O’Rahilly, V. Saudek, G. Yeo, 2015, Molecular metabolism.

Polyglutamines‐versatile biodegradable carriers

V. Saudek, F. Rypáček, J. Drobník, 1985 .

Partial lipodystrophy and insulin resistant diabetes in a patient with a homozygous nonsense mutation in CIDEC

S. O’Rahilly, V. Saudek, P. Murgatroyd, 2009, EMBO molecular medicine.

DIRECT FITTING OF STRUCTURE AND CHEMICAL SHIFT TO NMR SPECTRA

V. Saudek, Vladimir Saudek, R. Andrew AtkinsonVladimirSaudek, 1997 .

SMED-TLX-1 (NR2E1) is critical for tissue and body plan maintenance in Schmidtea mediterranea in fasting/feeding cycles.

V. Saudek, O. Raška, M. Kostrouchová, 2011, Folia biologica.

Solution structure of salmon calcitonin

V. Saudek, J. Hoflack, Jean-Philippe Meyer, 1991, Biopolymers.

The relationship between chemical shift and secondary structure in proteins

A. Pastore, V. Saudek, 1990 .

Chromotest estimation of SOS functions as a screening method for antitumor platinum complexes.

V. Saudek, E. Koutecká, J. Drobník, 1987, Neoplasma.

ENZYMATIC CLEAVAGE OF SIDE CHAINS OF SYNTHETIC WATER-SOLUBLE POLYMERS.

V. Saudek, J. Labský, J. Kálal, 1976 .

7Li nuclear-magnetic-resonance study of lithium binding to myo-inositolmonophosphatase.

V. Saudek, V. Sklenar, R. Atkinson, 1996, European journal of biochemistry.

1H n.m.r. study of poly(α,β-[N(2-hydroxyethyl)-d,l-aspartamide]

V. Saudek, F. Rypáček, 1988 .

Correlation between biochemical findings, structural and enzymatic abnormalities in mutated HMBS identified in six Israeli families with acute intermittent porphyria.

V. Saudek, X. Schneider-Yin, E. Minder, 2009, Blood cells, molecules & diseases.

Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity

S. O’Rahilly, V. Saudek, G. Yeo, 2021, Scientific Reports.

Prorenin Receptor Homologue VHA-20 is Critical for Intestinal pH Regulation, Ion and Water Management and Larval Development in C. elegans.

V. Saudek, K. Sebková, M. Kostrouchová, 2015, Folia biologica.

V. Saudek, M. Krause, M. Kostrouchová, 2015, PeerJ.

The Direct Determination of Protein Structure from Multidimensional NMR Spectra without Assignment

V. Saudek, R. Atkinson, 1996 .

1H‐NMR study of endothelin, sequence‐specific assignment of the spectrum and a solution structure

V. Saudek, J. Hoflack, J. Pelton, 1989, FEBS letters.

Polyaspartamide — a potential drug carrier

V. Saudek, J. Kálal, J. Vlasák, 2007 .

Solution structure of the DNA-binding domain of the yeast transcriptional activator protein GCN4.

T. Gibson, A. Pastore, V. Saudek, 1990, Protein engineering.

Solution structure of the basic region from the transcriptional activator GCN4.

T. Gibson, A. Pastore, V. Saudek, 1991, Biochemistry.

Mobility of secondary structure units of horse-muscle acylphosphatase. Relation to antigenicity.

R. J. Williams, V. Saudek, G. Ramponi, 1989, European journal of biochemistry.

Secondary structure of acylphosphatase from rabbit skeletal muscle. A nuclear magnetic resonance study.

R. J. Williams, V. Saudek, G. Ramponi, 1988, Journal of molecular biology.

Conformational study of poly(α,β‐L‐aspartic acid)

V. Saudek, P. Schmidt, Štěpánka Štokrová, 1982 .

The metabolic syndrome- associated small G protein ARL15 plays a role in adipocyte differentiation and adiponectin secretion

S. O’Rahilly, V. Saudek, I. Barroso, 2017, Scientific Reports.

FICD acts bi-functionally to AMPylate and de-AMPylate the endoplasmic reticulum chaperone BiP

V. Saudek, D. Ron, C. Rato, 2016, Nature Structural &Molecular Biology.

Novel Mutation (T273R) in Thyroid Hormone Receptor β Gene Provides Further Insight into Cryptic Negative Regulation by Thyroid Hormone.

V. Saudek, V. Hána, M. Kostrouchová, 2017, Folia biologica.

Fetally-encoded GDF15 and maternal GDF15 sensitivity are major determinants of nausea and vomiting in human pregnancy

Cleo M. Meek, V. Saudek, C. Hayward, 2023, bioRxiv.

Solution conformation of endothelin-3 by 1H NMR and distance geometry calculations

V. Saudek, J. Hoflack, J. Pelton, 1991, Neurochemistry International.

13C n.m.r. relaxation study of poly(aspartic acid)

V. Saudek, H. Pivcová, 1985 .

Nmr study of poly(aspartic acid). II. α‐ and β‐Peptide bonds in poly(aspartic acid) prepared by common methods

V. Saudek, J. Drobník, H. Pivcová, 1981 .

FICD acts bi-functionally to AMPylate and de-AMPylate the endoplasmic reticulum chaperone BiP

V. Saudek, D. Ron, C. Rato, 2016, Nature Structural &Molecular Biology.