P. Herdewijn

发表

Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.

H. Munier-Lehmann, V. Vanheusden, Philippe van Rompaey, 2003, Bioorganic & medicinal chemistry letters.

Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.

H. Munier-Lehmann, V. Vanheusden, P. Herdewijn, 2004, Journal of medicinal chemistry.

Synthesis and evaluation of thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.

H. Munier-Lehmann, V. Vanheusden, S. Pochet, 2002, Bioorganic & medicinal chemistry letters.

Characterization of modification sites during peptide synthesis using liquid secondary ion/collision-induced dissociation mass spectrometry and a computer program

P. Herdewijn, R. Busson, J. Rozenski, 1994 .

Identification of a novel resistance mutation for benzimidazole inhibitors of the HCV RNA-dependent RNA polymerase.

P. Herdewijn, L. Delang, M. Froeyen, 2012, Antiviral research.

Polyethylenimine but not cationic lipid improves antisense activity of 3'-capped phosphodiester oligonucleotides.

P. Herdewijn, T. Bettinger, J. Rémy, 1999, Antisense & nucleic acid drug development.

Complexation of lipofectamine and cholesterol-modified DNA sequences studied by single-molecule fluorescence techniques.

P. Herdewijn, J. Hofkens, F. D. De Schryver, 2007, Biomacromolecules.

Welcome Home, Systems Chemists!

P. Herdewijn, S. Otto, G. Kiedrowski, 2018 .

Welcome Home, Systems Chemists!

P. Herdewijn, S. Otto, G. von Kiedrowski, 2010 .

Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y(1) receptor ligands.

S. Moro, K. Jacobson, P. Herdewijn, 2000, Journal of medicinal chemistry.

ANTISENSE OLIGONUCLEOTIDES

S. Ferrari, P. Herdewijn, G. Martinelli, 2005 .

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

J. Kjems, Eugenio Fava, M. Zerial, 2009, Nucleic acids research.

Isolation and purification of a new kalimantacin/batumin-related polyketide antibiotic and elucidation of its biosynthesis gene cluster.

G. Volckaert, P. Herdewijn, R. Lavigne, 2010, Chemistry & biology.

Aminoacyl-tRNA synthetase inhibitors as potent and synergistic immunosuppressants.

P. Herdewijn, B. Sproat, A. Van Aerschot, 2008, Journal of medicinal chemistry.

Selective inhibition of trypanosomal glyceraldehyde-3-phosphate dehydrogenase by protein structure-based design: toward new drugs for the treatment of sleeping sickness.

F. Opperdoes, C. Verlinde, P. Herdewijn, 1994, Journal of medicinal chemistry.

Synthesis and structure-activity relationships of analogs of 2'-deoxy-2'-(3-methoxybenzamido)adenosine, a selective inhibitor of trypanosomal glycosomal glyceraldehyde-3-phosphate dehydrogenase.

P. Herdewijn, S. van Calenbergh, J. Rozenski, 1995, Journal of medicinal chemistry.

Hybridization properties of base-modified oligonucleotides within the double and triple helix motif

P. Herdewijn, I. Luyten, 1998 .

Imidazo[4,5-c]pyridines inhibit the in vitro replication of the classical swine fever virus and target the viral polymerase.

P. Herdewijn, M. Froeyen, J. Neyts, 2008, Antiviral research.

A pyrazolotriazolopyrimidinamine inhibitor of bovine viral diarrhea virus replication that targets the viral RNA-dependent RNA polymerase.

E. De Clercq, P. Herdewijn, M. Froeyen, 2009, Antiviral research.

Investigation of the DNA-dependent cyclohexenyl nucleic acid polymerization and the cyclohexenyl nucleic acid-dependent DNA polymerization

Piet Herdewijn, Matheus Froeyen, P. Herdewijn, 2005, Nucleic acids research.

Recognition of HNA and 1,5-anhydrohexitol nucleotides by DNA metabolizing enzymes.

P. Herdewijn, J. Rozenski, A. Van Aerschot, 2002, Biochimica et biophysica acta.

The naturally occurring N6-threonyl adenine in anticodon loop of Schizosaccharomyces pombe tRNAi causes formation of a unique U-turn motif

P. Herdewijn, K. Zanier, M. Sattler, 2006, Nucleic acids research.

Synthesis and evaluation of 5-substituted-2'-deoxyuridine monophosphate analogues as inhibitors of flavin-dependent thymidylate synthase in Mycobacterium tuberculosis

P. Herdewijn, J. Rozenski, M. Kögler, 2015 .

Synthesis and evaluation of 5-substituted 2'-deoxyuridine monophosphate analogues as inhibitors of flavin-dependent thymidylate synthase in Mycobacterium tuberculosis.

P. Herdewijn, J. Rozenski, C. Sibley, 2011, Journal of medicinal chemistry.

Discovery of a new Mycobacterium tuberculosis thymidylate synthase X inhibitor with a unique inhibition profile

P. Herdewijn, A. Marchand, H. Myllykallio, 2017, Biochemical pharmacology.

Title : Random-sequence genetic oligomer pools display an innate potential 1 for ligation and recombination

P. Herdewijn, B. T. Porebski, M. Abramov, 2022 .

Synthesis and in vitro evaluation of 2-amino-4-N-piperazinyl-6-(3,4-dimethoxyphenyl)-pteridines as dual immunosuppressive and anti-inflammatory agents.

P. Herdewijn, A. Marchand, Ling-Jie Gao, 2011, Bioorganic & medicinal chemistry letters.

Delivery of antisense oligonucleotides using cholesterol-modified sense dendrimers and cationic lipids.

P. Herdewijn, J. Rozenski, F. D. De Schryver, 2005, Bioconjugate chemistry.

Noncanonical DNA polymerization by aminoadenine-based siphoviruses

P. Marlière, S. Pochet, P. Herdewijn, 2021, Science.

Beneath the XNA world: Tools and targets to build novel biology

Vitor B. Pinheiro, P. Marlière, P. Herdewijn, 2020 .

Invading Escherichia coli Genetics with a Xenobiotic Nucleic Acid Carrying an Acyclic Phosphonate Backbone (ZNA).

P. Marlière, P. Herdewijn, J. Rozenski, 2019, Journal of the American Chemical Society.

Towards the enzymatic formation of artificial metal base pairs with a carboxy-imidazole-modified nucleotide.

P. Marlière, P. Herdewijn, F. Levi‐Acobas, 2019, Journal of inorganic biochemistry.

What is XNA?

P. Herdewijn, J. Chaput, 2019, Angewandte Chemie.

Reprint of: Non Canonical Genetic Material.

P. Herdewijn, E. Eremeeva, 2019, Current opinion in biotechnology.

Methylated Nucleobases: Synthesis and Evaluation for Base Pairing In Vitro and In Vivo.

Vitor B. Pinheiro, P. Marlière, P. Herdewijn, 2018, Chemistry.

Modulation of BACE1 Activity by Chemically Modified Aptamers

P. Marlière, B. de Strooper, P. Herdewijn, 2018, Chembiochem : a European journal of chemical biology.

A Single Amino Acid Substitution in Therminator DNA Polymerase Increases Incorporation Efficiency of Deoxyxylonucleotides

J. Robben, P. Herdewijn, J. Rozenski, 2018, Chembiochem : a European journal of chemical biology.

Non canonical genetic material.

P. Herdewijn, E. Eremeeva, 2019, Current opinion in biotechnology.

Metabolic Recruitment and Directed Evolution of Nucleoside Triphosphate Uptake in Escherichia coli.

P. Marlière, P. Herdewijn, B. Sargueil, 2018, ACS synthetic biology.

Base-Modified Nucleic Acids as a Powerful Tool for Synthetic Biology and Biotechnology.

P. Herdewijn, E. Eremeeva, L. Margamuljana, 2017, Chemistry.

Overcoming the membrane barrier: Recruitment of γ-glutamyl transferase for intracellular release of metabolic cargo from peptide vectors.

P. Marlière, S. Panke, P. Herdewijn, 2017, Metabolic engineering.

Chemical Morphing of DNA Containing Four Noncanonical Bases.

P. Marlière, P. Herdewijn, J. Rozenski, 2016, Angewandte Chemie.

Base pairing involving artificial bases in vitro and in vivo

P. Marlière, P. Herdewijn, J. Rozenski, 2015, Chemical science.

Synthesis of new biocarrier-nucleotide systems for cellular delivery in bacterial auxotrophic strains

P. Marlière, P. Herdewijn, V. Pezo, 2014 .

Molecular Dynamics of Double Stranded Xylo-Nucleic Acid.

P. Herdewijn, A. Ceulemans, Amutha Ramaswamy, 2017, Journal of chemical theory and computation.

A PKS/NRPS/FAS Hybrid Gene Cluster from Serratia plymuthica RVH1 Encoding the Biosynthesis of Three Broad Spectrum, Zeamine-Related Antibiotics

A. Aertsen, P. Herdewijn, J. Rozenski, 2013, PloS one.

The Kalimantacin Polyketide Antibiotics Inhibit Fatty Acid Biosynthesis in Staphylococcus aureus by Targeting the Enoyl‐Acyl Carrier Protein Binding Site of FabI

P. Herdewijn, Simone Kosol, Michiel Vanmeert, 2020, Angewandte Chemie.

The kalimantacin polyketide antibiotics inhibit fatty acid biosynthesis in Staphylococcus aureus by targeting the enoyl-acyl carrier protein binding site of FabI.

P. Herdewijn, Simone Kosol, Michiel Vanmeert, 2020, Angewandte Chemie.

Structural characterization of N-linked oligosaccharides from cellobiohydrolase I secreted by the filamentous fungus Trichoderma reesei RUTC 30.

R. Contreras, W. Fiers, P. Herdewijn, 1997, European journal of biochemistry.

Strategies in the Design of Antiviral Drugs

P. Herdewijn, E. Clercq, 2010 .

Cyclohexene Nucleic Acids (CeNA): Serum Stable Oligonucleotides that Activate RNase H and Increase Duplex Stability with Complementary RNA

P. Herdewijn, I. Luyten, A. Van Aerschot, 2000 .

3'-substituted 2',3'-dideoxynucleoside analogues as potential anti-HIV (HTLV-III/LAV) agents.

E. De Clercq, R. Pauwels, P. Herdewijn, 1987, Journal of medicinal chemistry.

Structural and binding study of modified siRNAs with the Argonaute 2 PAZ domain by NMR spectroscopy.

P. Herdewijn, E. Lescrinier, K. Nauwelaerts, 2011, Chemistry.

Nucleosides with Transposed Base or 4'-Hydroxymethyl Moieties and Their Corresponding Oligonucleotides.

P. Herdewijn, S. van Calenbergh, M. Renders, 2015, Chemical reviews.

Synthesis of 2'-O-α-D-ribofuranosyladenosine, monomeric unit of poly(ADP-ribose)

P. Herdewijn, S. Mikhailov, K. Nauwelaerts, 2008 .

Synthesis and Properties of Phosphorylated 3′-O-β-D-Ribofuranosyl-2′-deoxythymidine

P. Herdewijn, J. Rozenski, S. Mikhailov, 2003, Nucleosides, nucleotides & nucleic acids.

Anti-Hiv-1 Activity of 2′,3′-Dideoxinucleoside Analogues : Structure-Activity Relationship

R. Pauwels, P. Herdewijn, A. Aerschot, 1989 .

Enzymatically Catalyzed DNA Synthesis Using L‐Asp‐dGMP, L‐Asp‐dCMP, and L‐Asp‐dTMP

Philippe Marlière, Piet Herdewijn, Montserrat Terrazas, 2008, Chemistry & biodiversity.

Redesigning the leaving group in nucleic acid polymerization

P. Marlière, P. Herdewijn, 2012, FEBS letters.

Phosphoadenosine phosphate PPi : pyrophosphate RNA : ribonucleic acid RT : reverse transcriptase TPI : Triphosphoiminodicarboxylate tRNA : transfer-RNA UDP : uridine diphosphate Vmax : maximum rate XNA : xenobiotic nucleic acids

P. Marlière, P. Herdewijn, 2012 .

Synthesis and in vitro enzymatic and antiviral evaluation of phosphoramidate d4T derivatives as chain terminators.

C. Pannecouque, P. Herdewijn, E. Lescrinier, 2012, Organic & biomolecular chemistry.

Iminodipropionic Acid as the Leaving Group for DNA Polymerization by HIV‐1 Reverse Transcriptase

P. Herdewijn, E. Lescrinier, Camille Bouillon, 2011, Chembiochem : a European journal of chemical biology.

Polymerase-Dependent DNA Synthesis from Phosphoramidate-Activated Nucleotides

P. Herdewijn, Shiqiong Yang, 2011, Nucleosides, nucleotides & nucleic acids.

1',5'-anhydrohexitol oligonucleotides: Hybridisation and strand displacement with oligoribonucleotides, interaction with RNase H and HIV reverse transcriptase

Piet Herdewijn, Frank Seela, P. Herdewijn, 1997 .

Synthesis of Protected Amino Hexitol Nucleosides as Building Blocks for Oligonucleotide Synthesis.

P. Herdewijn, L. Beigelman, S. de Jonghe, 2018, The Journal of organic chemistry.

Uncommon Three-, Four-, and Six-Membered Nucleosides

P. Herdewijn, E. Groaz, 2013 .

Nucleic Acids with a Six‐Membered ‘Carbohydrate’ Mimic in the Backbone

P. Herdewijn, 2010, Chemistry & biodiversity.

Synthesis and base pairing properties of 1',5'-anhydro-L-hexitol nucleic acids (L-HNA).

P. Herdewijn, J. Rozenski, A. Van Aerschot, 2009, Chemistry.

ENZYMATIC RESOLUTION AND BASE PAIRING PROPERTIES OF D- AND L-CYCLOHEXENYL NUCLEIC ACIDS (CeNA)

P. Herdewijn, J. Rozenski, A. Van Aerschot, 2005, Nucleosides, nucleotides & nucleic acids.

Synthesis of enantiomeric-pure cyclohexenyl nucleoside building blocks for oligonucleotide synthesis

P. Herdewijn, R. Busson, J. Rozenski, 2004 .

Synthesis of 1,5‐Anhydrohexitol Building Blocks for Oligonucleotide Synthesis

P. Herdewijn, A. Aerschot, A. Marchand, 2003, Current protocols in nucleic acid chemistry.

CYCLOHEXENE NUCLEIC ACIDS (CeNA) FORM STABLE DUPLEXES WITH RNA AND INDUCE RNASE H ACTIVITY

P. Herdewijn, I. Luyten, M. Froeyen, 2001, Nucleosides, nucleotides & nucleic acids.

Improved hybridisation potential of oligonucleotides comprising O-methylated anhydrohexitol nucleoside congeners.

P. Herdewijn, R. Busson, J. Rozenski, 2001, Nucleic acids research.

INCREASED RNA AFFINITY OF HNA ANALOGUES BY INTRODUCING ALKOXY SUBSTITUENTS AT THE C-1 OR C-3 POSITION

P. Herdewijn, J. Rozenski, A. Van Aerschot, 2001, Nucleosides, nucleotides & nucleic acids.

RNase H mediated cleavage of RNA by cyclohexene nucleic acid (CeNA).

P. Herdewijn, B. Verbeure, J. Wang, 2001, Nucleic acids research.

Synthesis of protected D-altritol nucleosides as building blocks for oligonucleotide synthesis

P. Herdewijn, R. Busson, J. Rozenski, 1999 .

Replicative capability of anhydrohexitol analogues of nucleotides

P. Marlière, S. Pochet, P. Herdewijn, 1999 .

Properties of Oligonucleotides with Six Membered Carbohydrate Mimics and a 1,4-Relationship Between the Base Moiety and the Hydroxymethyl Group

P. Herdewijn, A. Aerschot, B. Allart, 1999 .

Incorporation of hexose nucleoside analogues into oligonucleotides: synthesis, base-pairing properties and enzymatic stability.

P. Herdewijn, R. Busson, A. Aerschot, 1992, Nucleic acids research.

Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.

E. De Clercq, P. Herdewijn, G. Janssen, 1993, Journal of medicinal chemistry.

1,5-ANHYDROHEXITOL NUCLEIC ACIDS, A NEW PROMISING ANTISENSE CONSTRUCT

P. Herdewijn, C. Hendrix, I. Verheggen, 1995 .

Synthesis and antiviral activity of 2-deoxy-1,5-anhydro-D-mannitol nucleosides containing a pyrimidine base moiety

P. Herdewijn, E. Clercq, M. Pérez-Pérez, 1996 .

A novel helper phage for HaloTag-mediated co-display of enzyme and substrate on phage.

J. Robben, P. Herdewijn, Wouter Delespaul, 2015, Biochemical and biophysical research communications.

Synthesis of 3′-Deoxy-3′-C-Hydroxymethyl-aldopentopyranosyl Nucleosides and their Incorporation in Oligonucleotides. Part II 1.

P. Herdewijn, A. Aerschot, H. D. Winter, 1995 .

2-Hydroxyethoxyethylated Bases as Acyclic Analogues of 1,5-Anhydrohexitol Nucleoside Derivatives

P. Herdewijn, J. Rozenski, A. Aerschot, 1994 .

The anti-HTLV-III (anti-HIV) and cytotoxic activity of 2',3'-didehydro-2',3'-dideoxyribonucleosides: a comparison with their parental 2',3'-dideoxyribonucleosides.

E. De Clercq, P. Herdewijn, S. Broder, 1987, Molecular pharmacology.

Cooperative dynamics of a DNA polymerase replicating complex.

Samuel L. C. Moors, J. Robben, P. Herdewijn, 2013, Biochimica et biophysica acta.

Synthesis of Poly(ADP‐ribose) Monomer Containing 2′‐O‐α‐D‐Ribofuranosyl Adenosine

P. Herdewijn, S. Mikhailov, V. Oslovsky, 2019, Current protocols in nucleic acid chemistry.

Ribavirin antagonizes inhibitory effects of pyrimidine 2',3'-dideoxynucleosides but enhances inhibitory effects of purine 2',3'-dideoxynucleosides on replication of human immunodeficiency virus in vitro

E. De Clercq, R. Pauwels, P. Herdewijn, 1987, Antimicrobial Agents and Chemotherapy.

Xylonucleic acid: synthesis, structure, and orthogonal pairing properties

P. Herdewijn, A. Ceulemans, E. Lescrinier, 2015, Nucleic acids research.

Oligodeoxynucleotides Containing N1‐Methyl‐2′‐Deoxyadenosine and N6‐Methyl‐2′‐Deoxyadenosine

Eric B. Roesch, P. Herdewijn, E. Timofeev, 2009, Current protocols in nucleic acid chemistry.

Characterization of synthetic human granulocyte chemotactic protein 2: usage of chemokine receptors CXCR1 and CXCR2 and in vivo inflammatory properties.

P. Herdewijn, I. Samson, P. Proost, 1997, Biochemistry.

Nucleotide analogues containing 2-oxa-bicyclo[2.2.1]heptane and l-alpha-threofuranosyl ring systems: interactions with P2Y receptors.

T Kendall Harden, Stefano Costanzi, Piet Herdewijn, 2004, Bioorganic & medicinal chemistry.

Structure-activity relationships of bisphosphate nucleotide derivatives as P2Y1 receptor antagonists and partial agonists.

K. Jacobson, P. Herdewijn, T. K. Harden, 1999, Journal of medicinal chemistry.

Influence of Threose Nucleoside Units on the Catalytic Activity of a Hammerhead Ribozyme

P. Herdewijn, Veerle Kempeneers, K. Vastmans, 2004, Chemistry & biodiversity.

Phenolic Profiling of Caffeic Acid O-Methyltransferase-Deficient Poplar Reveals Novel Benzodioxane Oligolignols1

P. Herdewijn, R. Busson, W. Boerjan, 2004, Plant Physiology.

Incorporation of a disaccharide nucleoside into the backbone of double-stranded DNA: crystallization and preliminary X-ray diffraction.

P. Herdewijn, K. V. Hecke, S. Mikhailov, 2005, Acta Crystallographica. Section F : Structural Biology and Crystallization Communications.

Practical method for the parallel synthesis of 2′-amido-2′-deoxyadenosines

P. Herdewijn, A. Link, S. V. Calenbergh, 1998 .

alpha-L-ribo-configured locked nucleic acid (alpha-L-LNA): synthesis and properties.

P. Herdewijn, J. Wengel, B. Verbeure, 2002, Journal of the American Chemical Society.

Synthesis and Structure–Activity Relationship Studies of Benzo[b][1,4]oxazin‐3(4H)‐one Analogues as Inhibitors of Mycobacterial Thymidylate Synthase X

P. Herdewijn, J. Rozenski, Michiel Vanmeert, 2019, ChemMedChem.

Intracellular metabolism and mechanism of anti-retrovirus action of 9-(2-phosphonylmethoxyethyl)adenine, a potent anti-human immunodeficiency virus compound.

E. De Clercq, P. Herdewijn, J. Balzarini, 1991, Proceedings of the National Academy of Sciences of the United States of America.

3-Deoxy-1,2-O-isopropylidene-3-C-methyl-5-O-(p-tolylsulfonyl)-d-ribofuranose

P. Herdewijn, N. Blaton, B. Doboszewski, 2007 .

Anti-norovirus activity of C7-modified 4-amino-pyrrolo[2,1-f][1,2,4]triazine C-nucleosides.

P. Herdewijn, J. Neyts, E. Groaz, 2020, European journal of medicinal chemistry.

Structure-Activity Relationship Study of a Potent α-Thrombin Binding Aptamer Incorporating Hexitol Nucleotides.

P. Herdewijn, F. Sica, A. Esposito, 2020, Chemistry.

Lipophilic nalmefene prodrugs to achieve a one-month sustained release.

J. Leysen, A. Megens, P. Herdewijn, 2016, Journal of controlled release : official journal of the Controlled Release Society.

Synthesis and Properties of Oligonucleotides Containing 2,4-Dihydroxycyclohexyl Nucleosides

P. Herdewijn, J. Rozenski, A. Aerschot, 2005 .

Antisense PNA tridecamers targeted to the coding region of Ha-ras mRNA arrest polypeptide chain elongation.

P. Herdewijn, A. Aerschot, P. Nielsen, 1999, Journal of molecular biology.

IDENTIFICATION OF THE EXOPOLYSACCHARIDE AMYLOVORAN BY NMR[1]

P. Herdewijn, R. Busson, E. Messens, 2001 .

Synthesis of 4-Deoxy-4-C-hydroxymethyl-α-L-Lyxo-Pyranosyl Thymine

P. Herdewijn, B. Doboszewski, 1996 .

Stereoelectronic properties of five anti-HSV-1 2'-deoxynucleosides analogues with heterocyclic substituents in the 5-position: a comparison with BVDU.

P. Herdewijn, A. Van Aerschot, F. Durant, 1994, Antiviral research.

5-Substituted-2′-deoxyuridines as anti-HSV-1 Agents: Synthesis and Structure Activity Relationship

P. Herdewijn, 1994 .

Hybridization properties of base-modified oligonucleotides within the double and triple helix motif

P. Herdewijn, I. Luyten, 1998 .

In vivo synthesis of complex N‐glycans by expression of human N‐acetylglucosaminyltransferase I in the filamentous fungus Trichoderma reesei

R. Contreras, M. Penttilä, P. Herdewijn, 1999, FEBS letters.

Synthesis and structure-activity relationships of 3,5-disubstituted-pyrrolo[2,3-b]pyridines as inhibitors of adaptor associated kinase 1 (AAK1) with antiviral activity

Jie Ying Gao, S. Knapp, J. Dye, 2019 .

Antibacterial 5'-O-(N-dipeptidyl)-sulfamoyladenosines.

P. Herdewijn, J. Rozenski, A. Van Aerschot, 2009, Bioorganic & medicinal chemistry.

Ajuga remota Benth.: from ethnopharmacology to phytomedical perspective in the treatment of malaria.

P. Herdewijn, P. E. Van den Steen, L. Maes, 2011, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Molecular simulation of cyclohexanyl nucleic acid (CNA) duplexes with CNA, DNA and RNA and CNA triloop and tetraloop hairpin structures.

P. Herdewijn, M. Froeyen, M. Abramov, 2016, Bioorganic & medicinal chemistry.

Characterization and sequence confirmation of unnatural amino acid containing peptide libraries using electrospray ionization mass spectrometry.

P. Herdewijn, J. Rozenski, A. Aerschot, 2002, Rapid communications in mass spectrometry : RCM.

HNA and ANA high-affinity arrays for detections of DNA and RNA single-base mismatches.

P. Herdewijn, M. Abramov, A. Van Aerschot, 2008, Biosensors & bioelectronics.

Oligonucleotides with 3-hydroxy-N-acetylprolinol as sugar substitute

P. Herdewijn, J. Rozenski, A. Aerschot, 1997 .

Acyclic oligonucleotides: possibilities and limitations

J. Hoogmartens, P. Herdewijn, R. Busson, 1993 .

Synthesis, enzymatic stability and base-pairing properties of oligothymidylates containing thymidine dimers with different N-substituted guanidine linkages

J. Hoogmartens, P. Herdewijn, R. Busson, 1993 .

Phosphoramidite building blocks for efficient incorporation of 2′-O-aminoethoxy(and propoxy)methyl nucleosides into oligonucleotides

P. Herdewijn, A. Aerschot, S. Mikhailov, 2008 .

Synthesis and Structure of 2′,3′-Dideoxy-3′-fluoro-5-cyanouridine

P. Herdewijn, A. Aerschot, N. Blaton, 1990 .

Synthesis of a Threosyl-C-nucleoside Phosphonate

P. Herdewijn, Pengju Nie, E. Groaz, 2019, European Journal of Organic Chemistry.

Xylo-C-nucleosides with a pyrrolo[2,1-f][1,2,4]triazin-4-amine heterocyclic base: Synthesis and antiproliferative properties.

P. Herdewijn, D. Daelemans, Pengju Nie, 2019, Bioorganic & medicinal chemistry letters.

Synthesis of a 3′-Deoxy-C -Nucleoside Phosphonate Bearing 9-Deazaadenine as Base Moiety

P. Herdewijn, G. Andrei, Pengju Nie, 2018, European Journal of Organic Chemistry.

Synthesis and Biological Evaluation of Pyrrolo[2,1‐f][1,2,4]triazine C‐Nucleosides with a Ribose, 2′‐Deoxyribose, and 2′,3′‐Dideoxyribose Sugar Moiety

P. Herdewijn, D. Daelemans, E. Lescrinier, 2018, ChemMedChem.

Bifunctional aryloxyphosphoramidate prodrugs of 2'-C-Me-uridine: synthesis and anti-HCV activity.

R. Ptak, P. Herdewijn, M. Murray, 2016, Organic & biomolecular chemistry.

An Overview of Marketed Nucleoside and Nucleotide Analogs

P. Herdewijn, S. de Jonghe, 2022, Current protocols.

Probing Ambiguous Base‐Pairs by Genetic Transformation with XNA Templates

P. Marlière, P. Herdewijn, C. Lambertucci, 2014, Chembiochem : a European journal of chemical biology.

1-O-Hexadecyl-2-desoxy-2-amino-sn-glycerol, a substrate for human sphingosine kinase.

P. Herdewijn, P. V. Van Veldhoven, S. Gijsbers, 2002, Biochimica et biophysica acta.

3′-Amidated 3′-Deoxyxylofuranose Analogues of N 6-−Cyclopentyladenosines: a New Class of Non-Xanthine Antagonists at the Adenosine A1 Receptor.

A. IJzerman, P. Herdewijn, S. V. Calenbergh, 1998 .

Synthesis of homo-N-nucleosides, a series of C1' branched-chain nucleosides

P. Herdewijn, J. Rozenski, N. Blaton, 1996 .

Use of Cyclohexene Epoxides in the Preparation of Carbocyclic Nucleosides

P. Herdewijn, J. Rozenski, J. Balzarini, 1996 .

XNA ligation using T4 DNA ligase in crowding conditions.

Vitor B. Pinheiro, P. Herdewijn, J. Rozenski, 2018, Chemical communications.

Neoglycoproteins as carriers for antiviral drugs: synthesis and analysis of protein-drug conjugates.

P. Herdewijn, G. Molema, D. Meijer, 1991, Journal of medicinal chemistry.

Inhibition of hepatitis B virus replication in vivo using lipoplexes containing altritol-modified antiviral siRNAs

Eric B. Roesch, P. Herdewijn, P. Marion, 2010, Artificial DNA, PNA & XNA.

TARGETING RNA WITH CONFORMATIONALLY RESTRICTED OLIGONUCLEOTIDES

P. Herdewijn, 1996 .

Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent.

E. De Clercq, R. Pauwels, L. Naesens, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis of (E)-3'-phosphonoalkenyl modified nucleoside phosphonates via a highly stereoselective olefin cross-metathesis reaction.

P. Herdewijn, Qiuya Huang, 2011, The Journal of organic chemistry.

Chemical incorporation of 1-methyladenosine into oligonucleotides.

P. Herdewijn, R. Busson, J. Rozenski, 2002, Nucleic acids research.

Synthesis, and in vitro Enzymatic and Antiviral Evaluation of d4T Polyphosphate Derivatives as Chain Terminators

C. Pannecouque, P. Herdewijn, Shiqiong Yang, 2012, Chemistry & biodiversity.

Reshaping an Acyclic Nucleoside Phosphonate into a Selective Anti-hepatitis B Virus Compound.

R. Ptak, P. Herdewijn, B. Korba, 2022, Journal of medicinal chemistry.

Carbohydrate chiral-pool approach to four enantiomerically pure 2-naphthylmethyl 3-hydroxy-2-methylbutanoates

P. Herdewijn, B. Doboszewski, 2008 .

Design and synthesis of nucleolipids as possible activated precursors for oligomer formation via intramolecular catalysis: stability study and supramolecular organization

P. Herdewijn, J. Rozenski, W. Dehaen, 2014, Journal of systems chemistry.

Synthesis of α-L-threose nucleoside phosphonates via regioselective sugar protection.

P. Herdewijn, Miyeon Jang, S. Dumbre, 2013, The Journal of organic chemistry.

Hybridization specificity, enzymatic activity and biological (Ha-ras) activity of oligonucleotides containing 2,4-dideoxy-beta-D-erythro-hexopyranosyl nucleosides.

P. Herdewijn, J. Rozenski, A. Van Aerschot, 1993, Nucleic acids research.

Further biological and molecular characterization of actinophage VWB.

P. Herdewijn, L. Mellaert, A. Aerschot, 1990, Journal of general microbiology.

New dsDNA‐Binding Hybrid Molecules Combining an Unnatural Peptide and an Intercalating Moiety

P. Herdewijn, J. Rozenski, A. Aerschot, 2003 .

Mutant Variants of the Substrate-Binding Protein DppA from Escherichia coli Enhance Growth on Nonstandard γ-Glutamyl Amide-Containing Peptides

T. Sharpe, S. Panke, P. Herdewijn, 2018, Applied and Environmental Microbiology.

A heterogeneous collection of novel antiviral pyrimidines

P. Herdewijn, S. V. Calenbergh, S. Calenbergh, 2000 .

A two-residue nascent-strand steric gate controls synthesis of 2′-O-methyl- and 2′-O-(2-methoxyethyl)-RNA

P. Herdewijn, M. Abramov, P. Holliger, 2022, Nature Chemistry.

Innate potential of random genetic oligomer pools for recombination

P. Herdewijn, M. Abramov, P. Holliger, 2018, bioRxiv.

Synthesis of Phosphonoglycine Backbone Units for the Development of Phosphono Peptide Nucleic Acids

P. Herdewijn, E. Groaz, B. Doboszewski, 2013 .

Improved Synthesis of Anhydrohexitol Building Blocks for Oligonucleotide Synthesis

P. Herdewijn, R. Busson, J. Rozenski, 1997 .

Hexitol Nucleic Acids (HNA): Synthesis and Properties

P. Herdewijn, A. Vanaerschot, G. Schepers, 1997 .

Mixed oligonucleotide analogues with an acyclic carbohydrate moiety and a N-cyanoguanidine functionality

C. Pannecouque, P. Herdewijn, J. Rozenski, 1994 .

Imidazopyridine- and purine-thioacetamide derivatives: potent inhibitors of nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1).

C. Müller, P. Herdewijn, J. Rozenski, 2014, Journal of medicinal chemistry.

Influence of the nucleobase and anchimeric assistance of the carboxyl acid groups in the hydrolysis of amino acid nucleoside phosphoramidates.

P. Herdewijn, A. Ceulemans, Servaas Michielssens, 2012, Chemistry.

Hydrolysis of aspartic acid phosphoramidate nucleotides: a comparative quantum chemical study.

P. Herdewijn, M. Froeyen, A. Ceulemans, 2009, Physical chemistry chemical physics : PCCP.

Synthesis and Antiviral Evaluation of 3′-Substituted Thymidine Analogues Derived from 3′-Amino-3′-deoxythymidine

C. Pannecouque, P. Herdewijn, J. Balzarini, 1995 .

Synthesis of 3′-C-branched 1′,5′-anhydromannitol nucleosides as new antiherpes agents

E. De Clercq, P. Herdewijn, E. Clercq, 1998 .

Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1 RT/DNA complexed with inhibitors doravirine and rilpivirine

C. Pannecouque, E. Arnold, P. Herdewijn, 2022, Proceedings of the National Academy of Sciences of the United States of America.

AFFINITY MODIFICATION OF EcoRII DNA METHYLTRANSFERASE BY THE DIALDEHYDE-SUBSTITUTED DNA DUPLEXES: MAPPING THE ENZYME REGION THAT INTERACTS WITH DNA

P. Herdewijn, A. Aerschot, E. V. Koudan, 2002, Nucleosides, nucleotides & nucleic acids.

Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral.

X. de Lamballerie, P. Herdewijn, L. Delang, 2014, The Journal of antimicrobial chemotherapy.

Theoretical Analysis of a Self-Replicator With Reduced Template Inhibition Based on an Informational Leaving Group

P. Herdewijn, Erwan Bigan, H. Mattelaer, 2016, Journal of Molecular Evolution.

Chimeric XNA: An Unconventional Design for Orthogonal Informational Systems.

P. Herdewijn, M. Froeyen, F. De Riccardis, 2018, Chemistry.

Comparison between the orthorhombic and tetragonal forms of the heptamer sequence d[GCG(xT)GCG]/d(CGCACGC).

P. Herdewijn, K. Robeyns, L. Van Meervelt, 2010, Acta crystallographica. Section F, Structural biology and crystallization communications.

Synthesis of trans(±)6-phenoxyacetamido-1-methylene-3,3-dicarboxymethyl-1-carbapenam

P. Herdewijn, P. Claes, H. Vanderhaeghe, 1982 .

Synthesis and biological evaluation of ceramide analogues with substituted aromatic rings or an allylic fluoride in the sphingoid moiety.

P. Herdewijn, S. van Calenbergh, A. Futerman, 2000, Journal of medicinal chemistry.

Efficient transfer of information from hexitol nucleic acids to RNA during nonenzymatic oligomerization.

L. Orgel, P. Herdewijn, A. Van Aerschot, 1999, Journal of the American Chemical Society.

Rational design of an XNA ligase through docking of unbound nucleic acids to toroidal proteins

Vitor B. Pinheiro, M. U. Mirza, P. Herdewijn, 2019, Nucleic acids research.

Rational design of an XNA ligase through docking of unbound nucleic acids to toroidal proteins

Vitor B. Pinheiro, M. U. Mirza, P. Herdewijn, 2019, Nucleic acids research.

Oligonucleotides containing a ribo-configured cyclohexanyl nucleoside: probing the role of sugar conformation in base pairing selectivity.

P. Herdewijn, A. Van Aerschot, G. Di Fabio, 2015, Organic & biomolecular chemistry.

Enantiomeric selection properties of β-homoDNA: enhanced pairing for heterochiral complexes.

P. Herdewijn, M. Froeyen, A. Van Aerschot, 2013, Angewandte Chemie.

Influence of the Incorporation of 1-(2,3-Dideoxy-β-D-Erythro-Hexopyranosyl)-Thymine on the Enzymatic Stability and Base-Pairing Properties of Oligodeoxynucleotides

P. Herdewijn, A. Aerschot, C. Urbanke, 2010 .

Recognition of threosyl nucleotides by DNA and RNA polymerases.

P. Herdewijn, J. Rozenski, Veerle Kempeneers, 2003, Nucleic acids research.

TNA as a Potential Alternative to Natural Nucleic Acids.

P. Herdewijn, 2001, Angewandte Chemie.

Structure of 1-(2-deoxy-β-D-ribopyranosyl)-5-iodouracil

P. Herdewijn, A. Aerschot, N. Blaton, 1991 .

The 5-chlorouracil:7-deazaadenine base pair as an alternative to the dT:dA base pair.

P. Marlière, P. Herdewijn, M. Abramov, 2016, Organic & biomolecular chemistry.

Structural characterization and biological evaluation of small interfering RNAs containing cyclohexenyl nucleosides.

P. Herdewijn, M. Froeyen, A. Aerschot, 2007, Journal of the American Chemical Society.

Heterocyclic modifications of oligonucleotides and antisense technology.

P. Herdewijn, 2000, Antisense & nucleic acid drug development.

Synthesis of 2′-N-Formamido Nucleosides and Biological Evaluation

P. Herdewijn, M. Abramov, M. Renders, 2009, Nucleosides, nucleotides & nucleic acids.

Reactivity of amino acid nucleoside phosphoramidates: a mechanistic quantum chemical study.

P. Herdewijn, A. Ceulemans, Servaas Michielssens, 2012, The journal of physical chemistry. A.

Structure-activity relationship study of the pyridine moiety of isothiazolo[4,3-b]pyridines as antiviral agents targeting cyclin G-associated kinase.

P. Herdewijn, M. Froeyen, Szu-Yuan Pu, 2019, Bioorganic & medicinal chemistry.

Base pairing properties of D- and L-cyclohexene nucleic acids (CeNA).

P. Herdewijn, J. Rozenski, A. Van Aerschot, 2003, Oligonucleotides.

2-Deoxy-2-α-C-(hydroxymethyl)adenosine as Potential anti-HCV Agent

P. Herdewijn, N. Chavain, 2011 .

Substrate-Dependence of Competitive Nucleotide Pyrophosphatase/Phosphodiesterase1 (NPP1) Inhibitors

C. Müller, P. Herdewijn, H. Stephan, 2017, Front. Pharmacol..

Positive cooperativity between acceptor and donor sites of the peptidoglycan glycosyltransferase.

P. Herdewijn, M. Petz, E. Breukink, 2015, Biochemical pharmacology.

Epimerization During Coupling to the Unnatural Amino Acid in Solid Phase Peptide Synthesis

P. Herdewijn, R. Busson, A. Aerschot, 2001 .

Synthesis and apoptogenic activity of fluorinated ceramide and dihydroceramide analogues.

P. Herdewijn, S. van Calenbergh, R. Busson, 1999, Bioorganic & medicinal chemistry letters.

Evaluation of anhydrohexitol nucleic acid, cyclohexenyl nucleic acid and d-altritol nucleic acid-modified 2'-O-methyl RNA mixmer antisense oligonucleotides for exon skipping in vitro.

P. Herdewijn, M. Abramov, R. Veedu, 2016, Chemical communications.

Synthesis and Antitumor Activity of C-7-Alkynylated and Arylated Pyrrolotriazine C-Ribonucleosides.

P. Herdewijn, D. Daelemans, L. Persoons, 2020, ACS medicinal chemistry letters.

Synthesis and Antibacterial Evaluation of a Novel Series of 2‐(1,2‐Dihydro‐3‐oxo‐3H‐pyrazol‐2‐yl)benzothiazoles

P. Herdewijn, J. Rozenski, K. Segers, 2011, Chemistry & biodiversity.

Enzymatic Formation of an Artificial Base Pair Using a Modified Purine Nucleoside Triphosphate.

P. Marlière, P. Herdewijn, L. Cavallo, 2019, ACS chemical biology.

Solution conformations and hydrolytic stability of 2′ ‐ and 3′ ‐substituted 2′,3′‐dideoxyribonucleosides, including some potential inhibitors of human immunodeficiency virus

P. Herdewijn, A. Aerschot, H. Hakala, 1992 .

Kinetics of the hydrolysis of 2′,3′-dideoxyguanosine: a potent anti-HIV agent

E. Roets, J. Hoogmartens, P. Herdewijn, 1991 .

Iron/Copper Co-Catalyzed Cross-Coupling Reaction for the Synthesis of 6-Substituted 7-Deazapurines and the Corresponding Nucleosides.

P. Herdewijn, D. Daelemans, L. Persoons, 2019, The Journal of organic chemistry.

Amidate Prodrugs of Deoxythreosyl Nucleoside Phosphonates as Dual Inhibitors of HIV and HBV Replication.

R. Ptak, C. Pannecouque, P. Herdewijn, 2016, Journal of medicinal chemistry.

Deoxythreosyl phosphonate nucleosides as selective anti-HIV agents.

E. De Clercq, C. Pannecouque, P. Herdewijn, 2005, Journal of the American Chemical Society.

Synthesis of tetradialdose phosphonate nucleosides as mimics of l-nucleotides

P. Herdewijn, E. Groaz, Qingfeng Li, 2019, Tetrahedron.

Synthesis and antiviral evaluation of base-modified deoxythreosyl nucleoside phosphonates.

C. Pannecouque, P. Herdewijn, Chao Liu, 2017, Organic & biomolecular chemistry.

SYNTHESIS AND ANTI-HIV ACTIVITY OF NEW 3'-O-PHOSPHONOMETHYL NUCLEOSIDES

P. Herdewijn, Michal Česnek, 2010 .

Synthesis of 3′-O-Phosphonoethyl Nucleosides with an Adenine and a Thymine Base Moiety

P. Herdewijn, Qiuya Huang, 2009, Nucleosides, nucleotides & nucleic acids.

Synthesis and antiviral evaluation of cyclopentyl nucleoside phosphonates.

P. Herdewijn, G. Andrei, Chao Liu, 2018, European journal of medicinal chemistry.

Amidate Prodrugs of Cyclic 9-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]adenine with Potent Anti-Herpesvirus Activity.

P. Herdewijn, M. Luo, G. Andrei, 2018, ACS medicinal chemistry letters.

Synthesis of a 3'-Fluoro-3'-deoxytetrose Adenine Phosphonate.

P. Herdewijn, S. de Jonghe, S. De, 2017, The Journal of organic chemistry.

L-Aspartic and l-glutamic acid ester-based ProTides of anticancer nucleosides: Synthesis and antitumoral evaluation.

P. Herdewijn, D. Daelemans, Ling-Jie Gao, 2016, Bioorganic & medicinal chemistry letters.

Synthesis and in Vitro Antiviral Activities of [(Dihydrofuran‐2‐yl)oxy]methyl‐phosphonate Nucleosides with 2‐Substituted Adenine as Base

C. Pannecouque, P. Herdewijn, Fei Liu, 2015, Chemistry & biodiversity.

Synthesis and biological evaluation of inosine phosphonates

P. Herdewijn, M. Abramov, 2010 .

Synthesis of 2-Amino-6-acetamidomethyl-9-(β-D-ribofuranosyl) purine

P. Herdewijn, A. Aerschot, W. Pfleiderer, 1989 .

9-[(2RS)-3-fluoro-2-phosphonylmethoxypropyl] derivatives of purines: a class of highly selective antiretroviral agents in vitro and in vivo.

E. De Clercq, P. Herdewijn, J. Balzarini, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis of 3′‐S‐Phosphonomethyl‐Modified Nucleoside Phosphonates with a 3′‐Deoxy‐3′‐thio‐α‐L‐threosyl Sugar Moiety

P. Herdewijn, Qiuya Huang, 2011 .

Synthesis and antiviral evaluation of some β-l-2′,3′-dideoxy-5-chloropyrimidine nucleosides and pronucleotides☆

E. De Clercq, P. Herdewijn, A. Aerschot, 2000 .

Modifications in Lignin and Accumulation of Phenolic Glucosides in Poplar Xylem upon Down-regulation of Caffeoyl-Coenzyme A O-Methyltransferase, an Enzyme Involved in Lignin Biosynthesis*

M. Van Montagu, P. Herdewijn, R. Busson, 2000, The Journal of Biological Chemistry.

Synthesis of a 2,4,6-trisubstituted 5-cyano-pyrimidine library and evaluation of its immunosuppressive activity in a Mixed Lymphocyte Reaction assay.

P. Herdewijn, J. Rozenski, M. Waer, 2013, Bioorganic & medicinal chemistry.

Comparative stability study of thymidine and (dideoxy-d-erythro-hexopyranosyl)thymine analogues monitored by capillary electrophoresis

E. Roets, J. Hoogmartens, P. Herdewijn, 1994 .

Double Protection of the Heterocyclic Base of Xanthosine and 2′-Deoxyxanthosine

P. Herdewijn, A. Aerschot, H. Vanderhaeghe, 1989 .

Protection of the Lactam Function of 2′-Deoxyinosine with A 2-(4-Nitrophenyl)-Ethyl Moiety

P. Herdewijn, G. Janssen, A. Aerschot, 1988 .

Silica Gel Functionalised with Different Spacers as Solid Support for Oligonucleotide Synthesis

P. Herdewijn, A. Aerschot, H. Vanderhaeghe, 1988 .

Tailoring Peptide–Nucleotide Conjugates (PNCs) for Nucleotide Delivery in Bacterial Cells

P. Herdewijn, E. Groaz, S. De, 2014 .

Incorporation of a disaccharide nucleoside into the backbone of double-stranded DNA: crystallization and preliminary X-ray diffraction.

P. Herdewijn, S. Mikhailov, K. Van Hecke, 2005, Acta crystallographica. Section F, Structural biology and crystallization communications.

Gelatin degradation assay reveals MMP-9 inhibitors and function of O-glycosylated domain.

P. Herdewijn, P. E. Van den Steen, G. Opdenakker, 2011, World journal of biological chemistry.

1,2,4-Triazole derivatives inhibiting the human immunodeficiency virus type 1 (HIV-1) in vitro

C. Pannecouque, P. Herdewijn, M. Froeyen, 2002 .

5-Hydroxytryptophan as a building block in oligopeptides using Fmoc/tBu SPPS

P. Herdewijn, R. Busson, J. Rozenski, 1995, Letters in Peptide Science.

Incorporation of 5-hydroxytryptophan in oligopeptides

P. Herdewijn, R. Busson, J. Rozenski, 1996 .

Synthesis of 3′-fluoromethylthio-, 3′-fluoromethylsulfinyl- and 3′-fluoromethylsulfonyl-substituted 3′-deoxythymidine

P. Herdewijn, R. Busson, J. Rozenski, 1994 .

Enzymatic Incorporation of Modified Purine Nucleotides in DNA

P. Herdewijn, M. Abramov, S. Agnello, 2017, Chembiochem : a European journal of chemical biology.

Strategy for the synthesis of pyridazine heterocycles and their derivatives.

P. Herdewijn, G. Van Lommen, Oscar Mammoliti, 2013, The Journal of organic chemistry.

A short and straightforward approach towards 6-amino and 6-aminoalkyl thiazolo[4,5-c]pyridazines

P. Herdewijn, K. Segers, S. D. Jonghe, 2013 .

Reverse transcriptase incorporation of 1,5-anhydrohexitol nucleotides.

S. Pochet, P. Herdewijn, K. Vastmans, 2001, Nucleic acids research.

Enzymatic incorporation in DNA of 1,5-anhydrohexitol nucleotides.

P. Marlière, S. Pochet, P. Herdewijn, 2000, Biochemistry.

Discovery of dual death-associated protein related apoptosis inducing protein kinase 1 and 2 inhibitors by a scaffold hopping approach.

P. Herdewijn, Ling-Jie Gao, S. de Jonghe, 2014, Journal of medicinal chemistry.

Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds.

J Desmyter, E. De Clercq, R. Pauwels, 1988, Journal of virological methods.

Both 2',3'-dideoxythymidine and its 2',3'-unsaturated derivative (2',3'-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro.

J Desmyter, E. De Clercq, R. Pauwels, 1987, Biochemical and biophysical research communications.

Enantioselective synthesis and conformational study of cyclohexene carbocyclic nucleosides

P. Herdewijn, Jing Wang, 1999 .

Synthesis of Peptidoglycan Units with UDP at the Anomeric Position

J. Frère, P. Herdewijn, R. Busson, 2005 .

Synthesis and leukemia cell growth inhibition of a series of 1,3-dithiazolylbenzene derivatives

P. Herdewijn, C. Bailly, C. Bal-Mahieu, 2004 .

Organophosphorus-catalyzed diaza-Wittig reaction: application to the synthesis of pyridazines.

P. Herdewijn, G. Van Lommen, Oscar Mammoliti, 2014, Organic & biomolecular chemistry.

A short and convenient strategy for the synthesis of pyridazines via Diaza–Wittig reaction

P. Herdewijn, Hassen Bel Abed, Oscar Mammoliti, 2012 .

Simple approach to the synthesis of 3-fluoro pyrazolo[1,5-a]pyrimidine analogues

P. Herdewijn, Hassen Bel Abed, Oscar Mammoliti, 2013 .

A novel and convenient strategy for the synthesis of phthalazines from an aryne precursor

P. Herdewijn, Hassen Bel Abed, Oscar Mammoliti, 2013 .

Synthesis and Biological Activity of the Mono- and Diamino Analogues of 2′-Deoxyadenosine, Cordycepin, 9-(3-Deoxy-α-D-Threo-Pentofuranosyl)-Adenine (A Structural Component of Agrocin 84) and 9-(2-Deoxy-α-D-Threo-Pentofuranosyl)Adenine

R. Pauwels, P. Herdewijn, G. Janssen, 1989 .

Toward L-homo-DNA: stereoselective de novo synthesis of β-L-erythro-hexopyranosyl nucleosides.

P. Herdewijn, A. Van Aerschot, Annalisa Guaragna, 2010, The Journal of organic chemistry.

Synthesis and Antiviral Evaluation of 3'-C -Hydroxymethyl-3'-O -Phosphonomethyl-β-D-5'-deoxyxylose Nucleosides

P. Herdewijn, Feng-Wu Liu, Wenke Xu, 2020 .

Cyclohexenyl nucleic acids: conformationally flexible oligonucleotides

Gert Sclep, Piet Herdewijn, P. Herdewijn, 2005, Nucleic acids research.

Synthesis and Structure–Activity Relationship Studies of 2‐(1,3,4‐Oxadiazole‐2(3H)‐thione)‐3‐amino‐5‐arylthieno[2,3‐b]pyridines as Inhibitors of DRAK2

P. Herdewijn, J. Rozenski, Ling-Jie Gao, 2014, ChemMedChem.

Synthesis of 5′-O-phosphonomethyl-2′,3′-didehydro-2′,3′-dideoxyuridine by use of P-methoxybenzyl as a N3-protecting group.

P. Herdewijn, L. Jie, A. V. Aeroschot, 1991 .

Relationship between structural properties and affinity for herpes simplex virus type 1 thymidine kinase of bromine substituted 5-heteroaromatic 2'-deoxyuridines.

P. Herdewijn, A. Van Aerschot, F. Durant, 1996, Antiviral research.

Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues.

E. De Clercq, P. Herdewijn, R. Snoeck, 1993, Journal of medicinal chemistry.

5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication.

E. De Clercq, C. Pannecouque, P. Herdewijn, 1991, Journal of medicinal chemistry.

Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.

E. De Clercq, P. Herdewijn, J. Balzarini, 1985, Journal of medicinal chemistry.

Anhydrohexitols as Conformationally Constrained Furanose Mimics, Design of an RNA‐Receptor

P. Herdewijn, 2005 .

Synthesis of Pyranose Nucleosides

P. Herdewijn, A. Aerschot, J. Balzarini, 1991 .

Synthesis of 3'-amino-3'-deoxyadenosine derivatives as potential-drugs for the treatment of malaria

P. Herdewijn, J. Soenens, G. François, 1995 .

Synthesis and anti-HIV activity of different sugar-modified pyrimidine and purine nucleosides.

E. De Clercq, R. Pauwels, P. Herdewijn, 1988, Journal of medicinal chemistry.

Synthesis and conformational analysis of 1-[2,4-dideoxy-4-C-hydroxymethyl-alpha-l-lyxopyranosyl]thymine.

V. Vanheusden, P. Herdewijn, S. van Calenbergh, 2004, The Journal of organic chemistry.

Synthesis of Pyranose Nucleosides and Related Nucleosides with a Six-Membered Carbohydrate Mimic

P. Herdewijn, 2003 .

5-Substituted pyrimidine 1,5-anhydrohexitols: conformational analysis and interaction with viral thymidine kinase.

P. Herdewijn, J. Wouters, 1999, Bioorganic & medicinal chemistry letters.

5-Substituted pyrimidines with a 1,5-anhydro-2, 3-dideoxy-D-arabino-hexitol moiety at N-1: synthesis, antiviral activity, conformational analysis, and interaction with viral thymidine kinase.

J. Champness, E. De Clercq, P. Herdewijn, 1998, Journal of medicinal chemistry.

N6-cyclopentyl-3'-substituted-xylofuranosyladenosines: a new class of non-xanthine adenosine A1 receptor antagonists.

A. IJzerman, J. K. von Frijtag Drabbe Künzel, P. Herdewijn, 1997, Journal of medicinal chemistry.

Synthesis of 2,4-dideoxy-.beta.-D-erythro-hexopyranosyl nucleosides

P. Herdewijn, J. Rozenski, G. Janssen, 1993 .

Studies on disaccharide nucleoside synthesis. Mechanism of the formation of trisaccharide purine nucleosides.

P. Herdewijn, N. Padyukova, S. Mikhailov, 1999, Nucleosides & nucleotides.

Thiazolo[3,2-a]benzimidazol-3(2H)-one derivatives: Structure-activity relationships of selective nucleotide pyrophosphatase/phosphodiesterase1 (NPP1) inhibitors.

Piet Herdewijn, C. Müller, P. Herdewijn, 2016, Bioorganic & medicinal chemistry.

Synthesis and antiviral activity of phosphonate derivatives of enantiomeric dihydro-2H-pyranyl nucleosides.

P. Herdewijn, J. Rozenski, J. Balzarini, 1995 .

Comprar Modified Nucleosides: in Biochemistry, Biotechnology and Medicine | Piet Herdewijn | 9783527318209 | Wiley

P. Herdewijn, 2008 .

Synthesis and Conformational Study of 3-Hydroxy-4-(Hydroxymethyl)-1-Cyclohexanyl Purines and Pyrimidines.

E. De Clercq, P. Herdewijn, R. Busson, 1997, The Journal of organic chemistry.

Synthesis of Deoxygenated Disaccharide Precursors for Modified Lipid II Synthesis

P. Herdewijn, R. Busson, De-qun Sun, 2006 .

Synthesis of homoceramides, novel ceramide analogues, and their lack of effect on the growth of hippocampal neurons.

P. Herdewijn, S. van Calenbergh, R. Busson, 2002, The Journal of organic chemistry.

A Scaffold‐Hopping Strategy toward the Identification of Inhibitors of Cyclin G Associated Kinase

P. Herdewijn, Junjun Tian, S. de Jonghe, 2018, ChemMedChem.

Synthesis of D‐Altritol Nucleosides with a 3′‐O‐Tert‐Butyldimethylsilyl Protecting Group

P. Herdewijn, A. Marchand, M. Abramov, 2004, Nucleosides, nucleotides & nucleic acids.

Synthesis, immunosuppressive activity and structure-activity relationship study of a new series of 4-N-piperazinyl-thieno[2,3-d]pyrimidine analogues.

P. Herdewijn, M. Waer, S. de Jonghe, 2010, Bioorganic & medicinal chemistry letters.

Development of synthetic strategies for the construction of pyrido[4,3-d]-pyrimidine libraries - the discovery of a new class of PDE-4 inhibitors

P. Herdewijn, J. Rozenski, Ling-Jie Gao, 2006 .

Synthesis and Leukemia Cell Growth Inhibition of a Series of 1,3-Dithiazolylbenzene Derivatives.

P. Herdewijn, C. Bailly, M. Pasqualini, 2004 .

N-aminoimidazole derivatives inhibiting retroviral replication via a yet unidentified mode of action.

E. De Clercq, C. Pannecouque, P. Herdewijn, 2003, Journal of medicinal chemistry.

Effect of (E)-5-(2-bromovinyl)uracil on the catabolism and antitumor activity of 5-fluorouracil in rats and leukemic mice.

E. De Clercq, P. Herdewijn, J. Balzarini, 1986, Cancer research.

Synthesis of new acyclic nucleoside phosphonates (ANPs) substituted on the 1′ and/or 2′ positions

P. Herdewijn, D. Marchand, S. Dumbre, 2011 .

Stereocontrolled synthesis of phosphonate derivatives of tetrahydro- and dihydro-2H-pyranyl nucleosides: The selectivity of the Ferrier rearrangement

P. Herdewijn, J. Rozenski, M. Pérez-Pérez, 1995 .

Isothiazolo[4,3-b]pyridines as inhibitors of cyclin G associated kinase : synthesis, structure-activity relationship studies and antiviral activity.

P. Herdewijn, J. Rozenski, S. Einav, 2015, MedChemComm.

Synthesis and Anti‐herpetic Activity of Phosphoramidate ProTides

P. Herdewijn, J. Balzarini, G. Andrei, 2013, ChemMedChem.

The synthesis of modified D- and L-anhydrohexitol nucleosides

P. Herdewijn, M. Andersen, S. Daluge, 1996 .

Six-membered Carbocyclic Nucleosides

P. Herdewijn, M. Froeyen, Jing Wang, 2003 .

The cyclohexene ring as bioisostere of a furanose ring: synthesis and antiviral activity of cyclohexenyl nucleosides.

E. De Clercq, P. Herdewijn, 2001, Bioorganic & medicinal chemistry letters.

Synthesis, enzymatic stability and physicochemical properties of oligonucleotides containing a N-cyanoguanidine linkage.

C. Pannecouque, P. Herdewijn, R. Busson, 1994 .

FULLY SELECTIVE INTRAMOLECULAR ORTHO PHOTOCYCLOADDITION OF 4-(4-METHOXY-PHENOXY)-3-(N3-BENZOYLTHYMIN-1-YL)BUT-1-ENE: AN UNPRECEDENTED BENZENE-THYMINE PHOTOCYCLOADDITION

P. Herdewijn, R. Busson, D. Keukeleire, 1997 .

γ-Hydroxyethyl piperidine iminosugar and N-alkylated derivatives: a study of their activity as glycosidase inhibitors and as immunosuppressive agents.

P. Herdewijn, Sougata Ghosh, D. Dhavale, 2014, Bioorganic & medicinal chemistry.

Synthesis of delta 3-1-methylene-1-carbacephems.

P. Herdewijn, P. Claes, H. Vanderhaeghe, 1986, Journal of medicinal chemistry.

Stereoselective synthesis of (−)-ara-cyclohexenyl-adenine

P. Herdewijn, B. Ruttens, A. Horvath, 2007 .

Resolution of aristeromycin enantiomers.

E. De Clercq, P. Herdewijn, J. Balzarini, 1985, Journal of medicinal chemistry.

A Convenient Route for the Synthesis of 3‐Deazaspongosine

P. Herdewijn, Omprakash Bande, 2014 .

1,2;3,4-Di-O-isopropylidene-l-galactose synthesis from its d-enantiomer

P. Herdewijn, B. Doboszewski, 2012 .

The in vitro and in vivo anti-retrovirus activity, and intracellular metabolism of 3'-azido-2',3'-dideoxythymidine and 2',3'-dideoxycytidine are highly dependent on the cell species.

E. De Clercq, R. Pauwels, P. Herdewijn, 1988, Biochemical pharmacology.

Reaction of adenine nucleosides, tosylated in the carbohydrate moiety, with lithium triethylborohydride

P. Herdewijn, 1989 .

A Novel and Convenient Strategy for the Synthesis of Phthalazines from an Aryne Precursor.

P. Herdewijn, Hassen Bel Abed, Oscar Mammoliti, 2014 .

Delta-di-carboxybutyl phosphoramidate of 2'-deoxycytidine-5'-monophosphate as substrate for DNA polymerization by HIV-1 reverse transcriptase.

P. Herdewijn, J. Vasseur, F. Morvan, 2009, Bioorganic & medicinal chemistry.

Discovery of 7-N-piperazinylthiazolo[5,4-d]pyrimidine analogues as a novel class of immunosuppressive agents with in vivo biological activity.

P. Herdewijn, J. Rozenski, M. Froeyen, 2011, Journal of medicinal chemistry.

Investigations on the anti-HIV activity of 2',3'-dideoxyadenosine analogues with modifications in either the pentose or purine moiety. Potent and selective anti-HIV activity of 2,6-diaminopurine 2',3'-dideoxyriboside.

E. De Clercq, R. Pauwels, P. Herdewijn, 1988, Biochemical pharmacology.

Synthesis and biological activity of 3'-azido- and 3'-amino substituted nucleoside analogs

P. Herdewijn, J. Balzarini, E. Clercq, 1985 .

Some 6-aza-5-substituted-2'-deoxyuridines show potent and selective inhibition of herpes simplex virus type 1 thymidine kinase.

R. T. Walker, P. Herdewijn, Ming Sun, 1998, Nucleosides & nucleotides.

Liquid chromatographic separation of diamino analogues of 2′- or 3′-deoxyadenosine from adenine on a poly(styrene-divinylbenzene) polymer column

E. Roets, J. Hoogmartens, P. Herdewijn, 1995 .

SYNTHESIS OF AN UNCHARGED CAMP-ANALOGUE

P. Herdewijn, J. Rozenski, F. Vandendriessche, 1995 .

Evaluation of the Kinetics of Hydrolysis of Monoamino Analogues of 2′- or 3′-Deoxyadenosine and of 9-(2-Deoxy-β-D-Threo-pentofuranosyl)Adenine or 9-(3-Deoxy-β-D-threo-pentofuranosyl)Adenine by Liquid Chromatography

E. Roets, J. Hoogmartens, P. Herdewijn, 1995 .

Liquid chromatographic separation of monoamino analogues of dideoxyadenosine and 9-(dideoxy-β-D-lyxo-pentofuranosyl)adenine from adenine

E. Roets, J. Hoogmartens, P. Herdewijn, 1993 .

Synthesis and anti-HIV activity of various 2'- and 3'-substituted 2',3'-dideoxyadenosines: a structure-activity analysis.

E. De Clercq, R. Pauwels, P. Herdewijn, 1987, Journal of medicinal chemistry.

Sensitive and rapid assay on MT-4 cells for detection of antiviral compounds against the AIDS virus.

E. De Clercq, R. Pauwels, P. Herdewijn, 1987, Journal of virological methods.

The 2',3'-dideoxyriboside of 2,6-diaminopurine selectively inhibits human immunodeficiency virus (HIV) replication in vitro.

E. De Clercq, R. Pauwels, P. Herdewijn, 1987, Biochemical and biophysical research communications.

Novel nucleoside strategies for anti-HIV and anti-HSV therapy.

P. Herdewijn, Piet Herdewijn, 1992, Antiviral research.

Synthesis of thymidine from 5-iodo-2'-deoxyuridine

P. Herdewijn, A. Aerschot, P. Wigerinck, 1991 .

Synthesis of Nucleosides Fluorinated in the Sugar Moiety. The Application of Diethylaminosulfur Trifluoride to the Synthesis of Fluorinated Nucleosides

P. Herdewijn, A. Aerschot, L. Kerremans, 1989 .

Access to a new type of homo-C-nucleosides with a ''split'' 8-deazapurine via a 1,3-dipolar cycloaddition reaction

P. Herdewijn, N. Blaton, O. Peeters, 1997 .

3′-Deoxy-3′-hydroxymethyl-aldopentopyranosyl nucleoside synthesis. Part I

P. Herdewijn, J. Rozenski, N. Blaton, 1995 .

Synthesis of β configured 2′,3′-unsaturated pentopyranosyl nucleosides

P. Herdewijn, N. Blaton, B. Doboszewski, 1995 .

Synthesis of a new branched chain hexopyranosyl nucleoside: 1-[2′,3′-dideoxy-3′-C-(hydroxymethyl)-α-D-erythro-pentopyranosyl]-thymine

P. Herdewijn, R. Busson, J. Rozenski, 1994 .

5-(thien-2-yl) uracil analogs: 5-(5-methylthien-2-yl)-2′-deoxyuridine, 5-(5-thien-2-yl)-2′-deoxyuridine, and 5-(5-bromothien-2-yl)-2′-deoxyuridine

P. Herdewijn, B. Norberg, F. Durant, 1996 .

Phosphorus Pentachloride Promoted gem-Dichlorination of 2′- and 3′-Deoxynucleosides

P. Herdewijn, E. Groaz, Fabio da Paixao Soares, 2018, Molecules.

Synthesis and Antiviral Activity of the alpha-Analogues of 1,5-Anhydrohexitol Nucleosides (1,5-Anhydro-2,3-dideoxy-D-ribohexitol Nucleosides).

E. De Clercq, P. Herdewijn, J. Rozenski, 1997, The Journal of organic chemistry.

3'-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.

Piet Herdewijn, Veerle Vanheusden, Hélène Munier-Lehmann, 2003, Journal of medicinal chemistry.

Synthesis of modified peptidoglycan precursor analogues for the inhibition of glycosyltransferase.

P. Herdewijn, B. Joris, M. Terrak, 2012, Journal of the American Chemical Society.

Synthesis of nicotinamide adenine dinucleotide (NAD) analogues with a sugar modified nicotinamide moiety

P. Herdewijn, R. Busson, D. Marchand, 2007 .

Synthetic Genetic Polymers Capable of Heredity and Evolution

John C. Chaput, Vitor B. Pinheiro, Piet Herdewijn, 2012, Science.

Phospho-carboxylic anhydride of a homologated nucleoside leads to primer degradation in the presence of a polymerase.

P. Herdewijn, Xiao-ping Song, Dhuldeo D. Kachare, 2014, Bioorganic & medicinal chemistry letters.

Differential patterns of intracellular metabolism of 2',3'-didehydro-2',3'-dideoxythymidine and 3'-azido-2',3'-dideoxythymidine, two potent anti-human immunodeficiency virus compounds.

E. De Clercq, P. Herdewijn, J. Balzarini, 1989, The Journal of biological chemistry.

2',3'-Dideoxynucleoside analogues as anti-HIV agents

P. Herdewijn, J. Balzarini, E. Clercq, 1993 .

The cyclohexene ring system as a furanose mimic: synthesis and antiviral activity of both enantiomers of cyclohexenylguanine.

E. De Clercq, P. Herdewijn, R. Snoeck, 2000, Journal of medicinal chemistry.

Isoguanine and 5-Methyl-Isocytosine Bases, In Vitro and In Vivo

Vitor B. Pinheiro, P. Marlière, P. Herdewijn, 2015, Chemistry.

Fmoc‐Protected Altritol Phosphoramidite Building Blocks and Their Application in the Synthesis of Altritol Nucleic Acids (ANAs)

P. Herdewijn, A. Aerschot, M. Abramov, 2007 .

Detection of RNA Hybridization by Pyrene‐Labeled Probes

P. Herdewijn, J. Rozenski, M. van der Auweraer, 2009, Chembiochem : a European journal of chemical biology.

A straightforward stereoselective synthesis of D- and L-5-hydroxy-4-hydroxymethyl-2-cyclohexenylguanine.

P. Herdewijn, J. Morral, C. Hendrix, 2001, The Journal of organic chemistry.

D-ALTRITOL NUCLEIC ACIDS (ANA) : HYBRIDISATION PROPERTIES, STABILITY, AND INITIAL STRUCTURAL ANALYSIS

P. Herdewijn, A. Aerschot, A. Van Aerschot, 1999 .

Anchimeric assistance of a 5'-O-carbonyl function for inversion of configuration at the 3'-carbon atom of 2'-deoxyadenosine. Synthesis of 3'-azido-2',3'-dideoxyadenosine and 3'-azido-2',3'-dideoxyinosine

P. Herdewijn, 1988 .

In Vivo Expression of Genetic Information from Phosphoramidate–DNA

P. Herdewijn, M. Abramov, E. Eremeeva, 2019, Chembiochem : a European journal of chemical biology.

Phosphonomethyl Oligonucleotides as Backbone-Modified Artificial Genetic Polymers.

Vitor B. Pinheiro, P. Marlière, P. Herdewijn, 2018, Journal of the American Chemical Society.

Synthesis of Alanine and Proline Amino Acids with Amino or Guanidinium Substitution on the Side Chain

P. Herdewijn, R. Busson, A. Aerschot, 2000 .

A Potential Prebiotic Route to Adenine from Hypoxanthine

P. Herdewijn, I. Lagoja, 2005, Chemistry & biodiversity.

Structural basis for the role of LYS220 as proton donor for nucleotidyl transfer in HIV-1 reverse transcriptase.

Samuel L. C. Moors, P. Herdewijn, A. Ceulemans, 2011, Biophysical chemistry.

SYNTHESIS AND ANTIVIRAL ACTIVITY OF ACYCLIC ANALOGUES OF 1,5-ANHYDROHEXITOL NUCLEOSIDES USING MITSUNOBU REACTION

P. Herdewijn, J. Rozenski, E. Clercq, 1996 .

Exploring the active site of herpes simplex virus type‐1 thymidine kinase by X‐ray crystallography of complexes with aciclovir and other ligands

Frank Wien, Piet Herdewijn, Tomasz Ostrowski, 1998, Proteins.

3-Phosphono-L-alanine as pyrophosphate mimic for DNA synthesis using HIV-1 reverse transcriptase.

P. Marlière, P. Herdewijn, M. Froeyen, 2011, Organic & biomolecular chemistry.

Influence of the Linkage between Leaving Group and Nucleoside on Substrate Efficiency for Incorporation in DNA Catalyzed by Reverse Transcriptase

P. Herdewijn, A. Giraut, 2010, Chembiochem : a European journal of chemical biology.

Iminodiacetic-phosphoramidates as metabolic prototypes for diversifying nucleic acid polymerization in vivo

P. Marlière, P. Herdewijn, M. Froeyen, 2010, Nucleic acids research.

Synthesis and Antiviral Activity of a Series of New Cyclohexenyl Nucleosides

E. De Clercq, P. Herdewijn, R. Busson, 2003, Antiviral chemistry & chemotherapy.

Synthesis and conformational behavior of purine and pyrimidine β-d-threo-hex-3'-enopyranosyl nucleosides

P. Herdewijn, I. Luyten, 1996 .

O-2-Alkylated Cytosine Acyclic Nucleoside Phosphonamidate Prodrugs Display Pan-Genotype Antiviral Activity against African Swine Fever Virus

Maohui Luo, P. Herdewijn, R. Vrancken, 2022, mSphere.

The Imidazopyrrolopyridine Analogue AG110 Is a Novel, Highly Selective Inhibitor of Pestiviruses That Targets the Viral RNA-Dependent RNA Polymerase at a Hot Spot for Inhibition of Viral Replication

E. De Clercq, P. Herdewijn, M. Froeyen, 2007, Journal of Virology.

Substituted 5-benzyl-2-phenyl-5H-imidazo[4,5-c]pyridines: a new class of pestivirus inhibitors.

E. De Clercq, P. Herdewijn, J. Rozenski, 2006, Bioorganic & medicinal chemistry letters.

A Novel, Highly Selective Inhibitor of Pestivirus Replication That Targets the Viral RNA-Dependent RNA Polymerase

E. De Clercq, P. Herdewijn, M. Froeyen, 2006, Journal of Virology.

3′‐(1,2,3‐Triazol‐1‐yl)‐2′,3′‐dideoxythymidine and 3′‐(1,2,3‐triazol‐1‐yl)‐2′,3′‐dideoxyuridine

P. Herdewijn, A. Aerschot, J. Balzarini, 2009 .

Syntheses of 5'-Nucleoside Monophosphate Derivatives with Unique Aminal, Hemiaminal, and Hemithioaminal Functionalities: A New Class of 5'-Peptidyl Nucleotides.

P. Herdewijn, L. Margamuljana, E. Groaz, 2016, Chemistry.

Comparative Liquid Chromatographic Stability Study of Thymidine and 1- (2-Deoxy-α-D-Erythro-Pentofuranosyl) Thymine

E. Roets, J. Hoogmartens, P. Herdewijn, 1994 .

Stability study of 2′-deoxyuridine by liquid chromatography

E. Roets, J. Hoogmartens, P. Herdewijn, 1993 .

d(GCGTAGC), an equilibrium between a hairpin structure and an unusual duplex

P. Herdewijn, R. Busson, J. Schraml, 1999 .

Nucleoside Analogues with a 1,4‐Dioxane, 1,4‐Oxathiane or 1,4‐Oxazine Ring Structure as the Carbohydrate Fragment

P. Herdewijn, G. Janssen, A. Aerschot, 2010 .

Difference in conformational diversity between nucleic acids with a six-membered 'sugar' unit and natural 'furanose' nucleic acids.

P. Herdewijn, M. Froeyen, E. Lescrinier, 2003, Nucleic acids research.

An easy and fast method for the evaluation of Staphylococcus epidermidis type I signal peptidase inhibitors.

P. Herdewijn, A. Van Aerschot, J. Anné, 2009, Journal of microbiological methods.

Modified nucleosides : in biochemistry, biotechnology and medicine

P. Herdewijn, 2008 .

Asymmetric Synthesis of New β-Lactam Lipopeptides as Bacterial Signal Peptidase I Inhibitors

P. Herdewijn, M. Froeyen, J. Anné, 2011 .

Peroxisomal β‐oxidation of 2‐methyl‐branched acyl‐CoA esters stereospecific recognition of the 2S‐methyl compounds by trihydroxycoprostanoyl‐CoA oxidase and pristanoyl‐CoA oxidase

P. Herdewijn, G. Mannaerts, P. V. Van Veldhoven, 1996, FEBS letters.

Synthesis of N-methyl-d-ribopyranuronamide nucleosides

P. Herdewijn, R. Busson, Shiqiong Yang, 2008, Tetrahedron.

Synthesis and antisense properties of fluoro cyclohexenyl nucleic acid (F-CeNA), a nuclease stable mimic of 2'-fluoro RNA.

P. Herdewijn, M. Egli, A. Jazayeri, 2012, The Journal of organic chemistry.

Antiviral activity of C-alkylated purine nucleosides obtained by cross-coupling with tetraalkyltin reagents.

E. De Clercq, P. Herdewijn, S. Ikeda, 1993, Journal of medicinal chemistry.

Straightforward C-8 alkylation of adenosine analogues with tetraalkyltin reagents

P. Herdewijn, A. Aerschot, P. Mamos, 1992 .

Ribosylation of pyrimidine 2'-deoxynucleosides

P. Herdewijn, E. Clercq, S. Mikhailov, 1996 .

Evaluation of the type I signal peptidase as antibacterial target for biofilm-associated infections of Staphylococcus epidermidis.

P. Herdewijn, A. Van Aerschot, J. Anné, 2009, Microbiology.

Regeneration of the antiviral drug (E)-5-(2-bromovinyl)-2'-deoxyuridine in vivo.

E. De Clercq, P. Herdewijn, C. Desgranges, 1984, Nucleic acids research.

Protection of 2,6-Diaminopurine 2′-Deoxyriboside

P. Herdewijn, R. Busson, J. Rozenski, 1997 .

Base pairing of anhydrohexitol nucleosides with 2,6-diaminopurine, 5-methylcytosine and uracil asbase moiety.

P. Herdewijn, R. Busson, A. Aerschot, 1999, Nucleic acids research.

Mapping of T7 RNA polymerase active site with novel reagents – oligonucleotides with reactive dialdehyde groups

P. Herdewijn, A. Van Aerschot, S. Kochetkov, 1999, FEBS letters.

DNA duplexes with reactive dialdehyde groups as novel reagents for cross-linking to restriction- modification enzymes.

P. Herdewijn, A. Van Aerschot, S. Mikhailov, 1997, Nucleic acids research.

AN EFFICIENT SYNTHESIS AND PHYSICO-CHEMICAL PROPERTIES OF 2'-O-D-RIBOFURANOSYLNUCLEOSIDES, MINOR TRNA COMPONENTS

P. Herdewijn, J. Rozenski, G. Janssen, 1997 .

Synthesis and Properties of Some 2′-O-d-Ribofuranosyl-nucleosides

P. Herdewijn, S. Mikhailov, A. D. Bruyn, 1995 .

Synthesis of Oligoribonucleotides Containing Pyrimidine 2'- O -[(Hydroxyalkoxy)methyl]ribonucleosides

P. Herdewijn, J. Rozenski, A. Aerschot, 2006 .

Synthesis and antiviral activity evaluation of 3'-fluoro-3'-deoxyribonucleosides: broad-spectrum antiviral activity of 3'-fluoro-3'-deoxyadenosine.

E. De Clercq, P. Herdewijn, G. Janssen, 1989, Antiviral research.

Synthesis of RNA Containing O‐β‐D‐Ribofuranosyl‐(1″2′)‐adenosine‐5″‐phosphate and 1‐Methyladenosine, Minor Components of tRNA

P. Herdewijn, J. Rozenski, S. Mikhailov, 2005, Chemistry & biodiversity.

Synthesis and cleavage experiments of oligonucleotide conjugates with a diimidazole-derived catalytic center.

P. Herdewijn, J. Rozenski, B. Verbeure, 2002, Bioconjugate chemistry.

Enzymatic Synthesis Using Polymerases of Modified Nucleic Acids and Genes

P. Herdewijn, E. Eremeeva, 2018, Enzymatic and Chemical Synthesis of Nucleic Acid Derivatives.

An Efficient Synthesis and Physico‐Chemical Properties of 2′‐O‐D‐ Ribofuranosylnucleosides, Minor tRNA Components.

P. Herdewijn, J. Rozenski, G. Janssen, 1997 .

3'-Fluoro-2',3'-dideoxy-5-chlorouridine: most selective anti-HIV-1 agent among a series of new 2'- and 3'-fluorinated 2',3'-dideoxynucleoside analogues.

E. De Clercq, R. Pauwels, P. Herdewijn, 1989, Journal of medicinal chemistry.

Anti-retrovirus activity of 3'-fluoro- and 3'-azido-substituted pyrimidine 2',3'-dideoxynucleoside analogues.

R. Pauwels, P. Herdewijn, M. Baba, 1988, Biochemical pharmacology.

Selective antiherpetic activity of carbocyclic analogues of (E)-5-(2-halogenovinyl)-2'-deoxyuridines: dependence on specific phosphorylation by viral thymidine kinase.

E. De Clercq, P. Herdewijn, A. Verbruggen, 1985, Biochemical and biophysical research communications.

Database Searching for Thymidine and Thymidylate Kinase Inhibitors Using Three-dimensional Structure-based Methods

M. Delarue, D. Manallack, E. De Clercq, 2002, Journal of enzyme inhibition and medicinal chemistry.

Synthesis of 3′-O-phosphonomethyl nucleosides with an adenine base moiety

P. Herdewijn, M. Renders, D. Viña, 2007 .

Synthesis and antiviral activity of 3'-heterocyclic substituted 3'-deoxythymidines.

E. De Clercq, P. Herdewijn, G. Janssen, 1990, Journal of medicinal chemistry.

Oligodeoxynucleotides containing 2'-deoxy-1-methyladenosine and Dimroth rearrangement

P. Herdewijn, E. Timofeev, S. Mikhailov, 2007 .

Mycobacterium tuberculosis Thymidine Monophosphate Kinase Inhibitors: Biological Evaluation and Conformational Analysis of 2′‐ and 3′‐Modified Thymidine Analogues

H. Munier-Lehmann, V. Vanheusden, P. Herdewijn, 2003 .

Synthesis and Antiviral Activity of 3-O-Phosphonomethyl Nucleosides

P. Herdewijn, Michal Česnek, 2010 .

Synthesis of 2'-chloro-2',3'-dideoxy-2',3'-didehydro nucleosides

P. Herdewijn, A. Aerschot, 2010 .

Amidate Prodrugs of O-2-Alkylated Pyrimidine Acyclic Nucleosides Display Potent Anti-Herpesvirus Activity.

P. Herdewijn, M. Luo, G. Andrei, 2020, ACS medicinal chemistry letters.

Synthesis and Antiviral Activity of 3′‐Heterocyclic Substituted 3′‐Deoxythymidines.

P. Herdewijn, G. Janssen, A. Aerschot, 1990 .

Oligodeoxynucleotides Containing 2′-Deoxy-1-methyladenosine and Dimroth Rearrangement.

P. Herdewijn, E. Timofeev, S. Mikhailov, 2007 .

Synthesis of Ribonucleosides by Condensation Using Trimethylsilyl Triflate

P. Herdewijn, H. Vorbrüggen, I. Lagoja, 2006, Current protocols in nucleic acid chemistry.

Structure-activity relationship of short-chain sphingoid bases as inhibitors of sphingosine kinase.

P. Herdewijn, S. van Calenbergh, R. Busson, 1999, Bioorganic & medicinal chemistry letters.

Pharmacology and Mechanisms of Action of Antiviral Drugs: Polymerase Inhibitors

P. Herdewijn, L. Delang, M. Froeyen, 2011 .

Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.

R. T. Walker, E. De Clercq, P. Herdewijn, 1986, Journal of medicinal chemistry.

SYNTHESIS AND ANTIVIRAL ACTIVITY OF THE CARBOCYCLIC ANALOGS OF (E)‐5‐(2‐HALOVINYL)‐2′‐DEOXYURIDINES AND (E)‐5‐(2‐HALOVINYL)‐2′‐DEOXYCYTIDINES

P. Herdewijn, J. Balzarini, E. Clercq, 1985 .

Alpha, beta- and beta, gamma-methylene 5'-phosphonate derivatives of 3'-azido-2',3'-dideoxythymidine-5'-triphosphate. Correlation between affinity for reverse transcriptase, susceptibility to hydrolysis by phosphodiesterases and anti-retrovirus activity.

E. De Clercq, R. Pauwels, P. Herdewijn, 1988, Biochemical pharmacology.

Synthesis of trideoxyhexopyranosylated and hexenopyranosylated nucleoside analogues as potential anti‐HIV agents

P. Herdewijn, A. Aerschot, 2010 .

Alpha-homo-DNA and RNA form a parallel oriented non-A, non-B-type double helical structure.

P. Herdewijn, R. Busson, J. Rozenski, 2001, Chemistry.

Glycosylation of 1-Aminoimidazole-2(3H)-thiones

P. Herdewijn, A. Aerschot, C. Hendrix, 2000 .

Synthesis and Anti‐HIV Activity of Guanine Modified Fluorinated Acyclic Nucleoside Phosphonate Derivatives

P. Herdewijn, M. Luo, D. Schols, 2019, Chemistry & biodiversity.

Expanding the Antiviral Spectrum of 3-Fluoro-2-(phosphonomethoxy)propyl Acyclic Nucleoside Phosphonates: Diamyl Aspartate Amidate Prodrugs.

R. Ptak, P. Herdewijn, M. Luo, 2017, Journal of medicinal chemistry.

SYNTHESIS OF N 6-ALKYLATED ADENOSINE DERIVATIVES

C. Pannecouque, P. Herdewijn, J. Rozenski, 1996 .

Homo-N-nucleosides: Incorporation into oligonucleotides and antiviral activity

P. Herdewijn, R. Busson, A. Aerschot, 1996 .

Anno 2021: Which antivirals for the coming decade?

E. De Clercq, P. Herdewijn, E. Groaz, 2021, Annual Reports in Medicinal Chemistry.

Structural requirements for antiviral activity in nucleosides

P. Herdewijn, 1997 .

Role of thymidine kinase and thymidylate synthetase in the cytostatic, antimetabolic, and antitumor effects of the carbocyclic analogue of 5-nitro-2'-deoxyuridine. A comparison with 5-nitro-2'-deoxyuridine.

E. De Clercq, P. Herdewijn, J. Balzarini, 1985, Molecular pharmacology.

Oligonucleotide promoted peptide bond formation using a tRNA mimicking approach.

P. Herdewijn, W. Dehaen, N. Papastavrou, 2017, Chemical communications.

Achiral, acyclic nucleic acids: synthesis and biophysical studies of a possible prebiotic polymer.

P. Herdewijn, J. Rozenski, P. Srivastava, 2015, Organic & biomolecular chemistry.

Enzymatic and Structural Analysis of Inhibitors Designed against Mycobacterium tuberculosis Thymidylate Kinase

Marc Delarue, Piet Herdewijn, Ahmed Haouz, 2003, The Journal of Biological Chemistry.

α-l-ribo-Configured Locked Nucleic Acid (α-L-LNA): Synthesis and Properties

Piet Herdewijn, Birgit Verbeure, P. Herdewijn, 2002 .

Synthesis and conformational analysis of a ribo-type cyclohexenyl nucleoside.

P. Herdewijn, A. Van Aerschot, K. Nauwelaerts, 2005, Journal of Organic Chemistry.

Structure—Activity Relationship of Short-Chain Sphingoid Bases as Inhibitors of Sphingosine Kinase.

P. Herdewijn, R. Busson, S. Spiegel, 2000 .

Effect of aromatic short-chain analogues of ceramide on axonal growth in hippocampal neurons.

G. Slegers, P. Herdewijn, S. van Calenbergh, 1999, Journal of medicinal chemistry.

Synthesis of a Nucleobase-Modified ProTide Library.

P. Herdewijn, Ling-Jie Gao, S. D. Jonghe, 2016, Organic letters.

Mechanism of the potentiating effect of ribavirin on the activity of 2',3'-dideoxyinosine against human immunodeficiency virus.

E. De Clercq, P. Herdewijn, J. Balzarini, 1991, The Journal of biological chemistry.

2',3'-didehydro-2',3'-dideoxy-5-chlorocytidine is a selective anti-retrovirus agent.

E. De Clercq, P. Herdewijn, A. Aerschot, 1989, Biochemical and biophysical research communications.

5-Chloro-substituted derivatives of 2', 3'-didehydro-2',3'-dideoxyuridine, 3'-fluoro-2',3'-dideoxyuridine and 3'-azido-2',3'-dideoxyuridine as anti-HIV agents.

E. De Clercq, P. Herdewijn, J. Balzarini, 1989, Biochemical pharmacology.

Introduction of a cyano group at the 2-position of an (R,S)-3-hydroxy-2-(phosphonomethoxy)propyl (HPMP) derivative of thymine elicits selective anti-HBV activity.

R. Ptak, P. Herdewijn, M. Prichard, 2021, RSC medicinal chemistry.

Potent and selective anti-HTLV-III/LAV activity of 2',3'-dideoxycytidinene, the 2',3'-unsaturated derivative of 2',3'-dideoxycytidine.

E. De Clercq, R. Pauwels, P. Herdewijn, 1986, Biochemical and biophysical research communications.

Synthesis of 2′-Deoxy-2′ -Fluoro-D-Arabinopyranopyranosyl Nucleosides and Their 3′,4′-Seco analogues

P. Herdewijn, R. Busson, A. Aerschot, 1991 .

Comparative In Vitro Anti-Hepatitis C Virus Activities of a Selected Series of Polymerase, Protease, and Helicase Inhibitors

P. Herdewijn, R. Bartenschlager, J. Neyts, 2008, Antimicrobial Agents and Chemotherapy.

Differential inhibitory effects of several pyrimidine 2',3'-dideoxynucleoside 5'-triphosphates on the activities of reverse transcriptase and various cellular DNA polymerases.

E. De Clercq, P. Herdewijn, J. Balzarini, 1989, Molecular Pharmacology.

Structural Study of Two 5-Heteroaromatic-2′ deoxyuridines and Their 5-Bromine-heteroaromatic Analogues: Theoretical Conformational Analysis and NMR Experiments

P. Herdewijn, R. Busson, F. Durant, 1997 .

The 2',3'-dideoxyriboside of 2,6-diaminopurine and its 2',3'-didehydro derivative inhibit the deamination of 2',3'-dideoxyadenosine, an inhibitor of human immunodeficiency virus (HIV) replication.

E. De Clercq, P. Herdewijn, J. Balzarini, 1987, Biochemical and biophysical research communications.

Divers Stereoisomers of N-Acetylhydroxyprolinol as Sugar Substitute in Oligonucleotides

P. Herdewijn, A. Aerschot, G. Ceulemans, 1998 .

Oligonucleotide analogues with 4-hydroxy-N-acetylprolinol as sugar substitute

P. Herdewijn, J. Rozenski, A. Aerschot, 1997 .

TARGETING RNA WITH CONFORMATIONALLY RESTRICTED OLIGONUCLEOTIDES

P. Herdewijn, 1996 .

Synthesis of 2′‐Deoxy‐5‐(isothiazol‐5‐yl)uridine and Its Interaction with the HSV‐1 Thymidine Kinase

P. Herdewijn, R. Busson, I. Luyten, 1996 .

Amino acid phosphoramidate nucleotides as alternative substrates for HIV-1 reverse transcriptase.

P. Herdewijn, O. Adelfinskaya, 2007, Angewandte Chemie.

5'-O-phosphonomethyl-2',3'-dideoxynucleosides: synthesis and anti-HIV activity.

J. Hoogmartens, E. De Clercq, P. Herdewijn, 1990, Journal of medicinal chemistry.

Understanding the binding of 5-substituted 2'-deoxyuridine substrates to thymidine kinase of herpes simplex virus type-1.

P. Herdewijn, H. De Winter, 1996, Journal of medicinal chemistry.

Straightforward Synthesis of Labeled and Unlabeled Pyrimidine d4Ns via 2′,3′‐Diyne seco Analogues through Olefin Metathesis Reactions

P. Herdewijn, J. Rozenski, S. Nolan, 2003 .

Nucleotides. Part XXXIVSynthesis of Modified Oligomeric 2′–5′A Analogues: Potential Antiviral Agents

P. Herdewijn, W. Pfleiderer, K. Ruf, 1991 .

Hydroxy fatty acids for the delivery of dideoxynucleosides as anti-HIV agents.

C. Pannecouque, P. Herdewijn, E. Lescrinier, 2014, Bioorganic & Medicinal Chemistry Letters.

Selective inhibition of human immunodeficiency virus (HIV) by 3'-azido-2', 3'-dideoxyguanosine in vitro.

E. De Clercq, R. Pauwels, P. Herdewijn, 1987, Biochemical and biophysical research communications.

5-Halogeno-3'-fluoro-2',3'-dideoxyuridines as inhibitors of human immunodeficiency virus (HIV): potent and selective anti-HIV activity of 3'-fluoro-2',3'-dideoxy-5-chlorouridine.

E. De Clercq, R. Pauwels, P. Herdewijn, 1989, Molecular pharmacology.

Synthesis and Evaluation of 6‐Aza‐2′‐deoxyuridine Monophosphate Analogs as Inhibitors of Thymidylate Synthases, and as Substrates or Inhibitors of Thymidine Monophosphate Kinase in Mycobacterium tuberculosis

H. Munier-Lehmann, P. Herdewijn, R. Busson, 2012, Chemistry & biodiversity.

Synthesis of 3′-fluoro-4′-amino-hexitol nucleosides with a pyrimidine nucleobase as building blocks for oligonucleotides

P. Herdewijn, E. Lescrinier, L. Beigelman, 2019, Tetrahedron.

Structure of the alpha-homo-DNA:RNA duplex and the function of twist and slide to catalogue nucleic acid duplexes.

P. Herdewijn, E. Lescrinier, K. Nauwelaerts, 2007, Chemistry.

Dimeric building blocks with N-cyanoguanidine linkage for oligonucleotide synthesis

C. Pannecouque, P. Herdewijn, A. Aerschot, 1992 .

Incorporation of carbocyclic (E)-5-(2-iodovinyl)-2'-deoxyuridine (C-IVDU) into DNA of herpes simplex virus-infected cells.

E. De Clercq, P. Herdewijn, A. Verbruggen, 1985, Antiviral research.

Facile Synthesis of 3′-C-Branched 1,5-Anhydrohexitol Nucleosides

P. Herdewijn, N. Hossain, 1998 .

N8-Glycosylated 8-Azapurine and Methylated Purine Nucleobases: Synthesis and Study of Base Pairing Properties.

P. Herdewijn, P. Srivastava, E. Lescrinier, 2019, The Journal of organic chemistry.

1′, 5′ ‐Anhydrohexitol Oligonucleotides: Synthesis, Base Pairing and Recognition by Regular Oligodeoxyribonucleotides and Oligoribonucleotides

P. Herdewijn, A. Aerschot, A. Van Aerschot, 1997 .

Dimeric Building Blocks with N-Cyanoguanidine Linkage for Oligonucleotide Synthesis.

C. Pannecouque, P. Herdewijn, A. Aerschot, 1993 .

Synthesis of Thymidine Analogues with a Cyanoimido Substituent

P. Herdewijn, A. Aerschot, J. Balzarini, 1991 .

Facile Synthesis of 3′-C-Branched 1,5-Anhydrohexitol Nucleosides.

P. Herdewijn, N. Hossain, 1999 .

An acyclic 5-nitroindazole nucleoside analogue as ambiguous nucleoside.

P. Herdewijn, J. Rozenski, A. Van Aerschot, 1995, Nucleic acids research.

Conjugation of Oligonucleotides to 3′‐Polar Moieties

P. Herdewijn, J. Rozenski, G. Verhoeven, 2010 .

Incorporation of 2'-amido-nucleosides in oligodeoxynucleotides and oligoribonucleotides as a model for 2'-linked conjugates

Jef Rozenski, Piet Herdewijn, Bart Devreese, 1995, Nucleic Acids Res..

SOLID PHASE SYNTHESIS OF 2',5'-OLIGOADENYLATES CONTAINING 3'-FLUORINATED RIBOSE

P. Herdewijn, A. Aerschot, P. Torrence, 1995 .

Inhibition of MDR1 gene expression by chimeric HNA antisense oligonucleotides.

P. Herdewijn, A. Marchand, Dong Xu, 2004, Nucleic acids research.

Nucleotides. Part XXXI. Modified Oligomeric 2′–5′ A Analogues: Synthesis of 2′–5′ oligonucleotides with 9‐(3′‐azido‐3′‐deoxy‐β‐D‐xylofuranosyl)adenine and 9‐(3′‐amino‐3′‐deoxy‐β‐D‐xylofuranosyl)adenine as modified nucleosides

P. Herdewijn, W. Pfleiderer, R. Charubala, 1989 .

Simple approach to 1-O-protected (R)- and (S)-glycerols from l- and d-arabinose for glycerol nucleic acids (GNA) monomers research

P. Herdewijn, B. Doboszewski, 2011 .

Replication of hexitol oligonucleotides as a prelude to the propagation of a third type of nucleic acid in vivo.

Philippe Marlière, Piet Herdewijn, Sylvie Pochet, 2003, Comptes rendus biologies.

Structure Determination of the Top‐Loop of the Conserved 3′‐Terminal Secondary Structure in the Genome of Flaviviruses

Roger A. Jones, P. Herdewijn, N. Dyubankova, 2010, Chembiochem : a European journal of chemical biology.

Orthogonal Genetic Systems

Marcel Hollenstein, John C Chaput, Piet Herdewijn, 2019, Chembiochem : a European journal of chemical biology.

Discovery of an Acyclic Nucleoside Phosphonate that Inhibits Mycobacterium tuberculosis ThyX Based on the Binding Mode of a 5‐Alkynyl Substrate Analogue

P. Herdewijn, M. Froeyen, J. Rozenski, 2013, ChemMedChem.

Conformational Analysis of Substituent Effects on the Sugar Puckering Mode and the anti-HIV Activity of 2′,3′-Dideoxypyrimidine Nucleosides

P. Herdewijn, A. Aerschot, A. Van Aerschot, 1993 .

Branched-chain nucleosides: Synthesis of 3′-deoxy-3′-C- hydroxymethyl-α-l-lyxopyranosyl thymine and 3′-deoxy- 3′-C-hydroxymethyl-α-l-threofuranosyl thymine.

P. Herdewijn, B. Doboszewski, 1996 .

Synthesis of Novel N-substituted guanidine linked nucleoside dimers and their incorporation into oligonucleotides

J. Hoogmartens, P. Herdewijn, A. Aerschot, 1993 .

Synthesis and antiviral activity of 5-heteroaryl-substituted 2'-deoxyuridines.

E. De Clercq, P. Herdewijn, R. Snoeck, 1991, Journal of medicinal chemistry.

2′-O-Hydroxyalkoxymethylribonucleosides and their Incorporation into Oligoribonucleotides

P. Herdewijn, J. Rozenski, R. Juliano, 2006, Nucleosides, nucleotides & nucleic acids.

Synthesis and antiviral activity of acyclic nucleosides with a 3(S),5-dihydroxypentyl or 4(R)-methoxy-3(S),5-dihydroxypentyl side chain.

J. Hoogmartens, E. De Clercq, P. Herdewijn, 1992, Journal of medicinal chemistry.

Potent and selective activity of 3'-azido-2,6-diaminopurine-2',3'-dideoxyriboside, 3'-fluoro-2,6-diaminopurine-2',3'-dideoxyriboside, and 3'-fluoro-2',3'-dideoxyguanosine against human immunodeficiency virus.

E. De Clercq, R. Pauwels, P. Herdewijn, 1988, Molecular pharmacology.

Synthesis and Conformational Analysis of 2′‐Deoxy‐2′‐(3‐methoxybenzamido)adenosine, a rational‐designed inhibitor of trypanosomal glyceraldehyde phosphate dehydrogenase (GAPDH)

C. Verlinde, W. Hol, P. Herdewijn, 1994 .

Synthesis of an apionucleoside family and discovery of a prodrug with anti-HIV activity.

Davy Sinnaeve, P. Herdewijn, S. van Calenbergh, 2014, The Journal of organic chemistry.

Glycosylation of 1‐Aminoimidazole‐2(3H)‐thiones.

P. Herdewijn, A. Aerschot, C. Hendrix, 2001 .

Unexpected Shift to a 4-Imino Tautomer Upon N4-Acylation of 5-Methylcytosin-1-yl Nucleoside Analogues

P. Herdewijn, R. Busson, A. Aerschot, 1999 .

Synthesis and evaluation of C-5 modified 2'-deoxyuridine monophosphates as inhibitors of M. tuberculosis thymidylate synthase.

P. Herdewijn, S. Kochetkov, L. Alexandrova, 2015, Bioorganic & medicinal chemistry.

Liquid chromatographic study of the stability of 5-halogeno-2'-deoxyuridines.

A. Van Schepdael, E. Roets, J. Hoogmartens, 1993, Journal of pharmaceutical and biomedical analysis.

On the Enzymatic Formation of Metal Base Pairs with Thiolated and pKa‐Perturbed Nucleotides

P. Marlière, P. Herdewijn, F. Levi‐Acobas, 2019, Chembiochem : a European journal of chemical biology.

2′-Deoxyuridines with a 5-Heteroaromatic Substituent: Synthesis and Biological Evaluation

E. De Clercq, C. Pannecouque, P. Herdewijn, 1995 .

Synthesis of nucleoside analogues with a 1,5-anhydrohexitol moiety

P. Herdewijn, A. Aerschot, I. Verheggen, 1993 .

Conformationally restricted carbohydrate-modified nucleic acids and antisense technology.

P. Herdewijn, P Herdewijn, 1999, Biochimica et biophysica acta.

Enzymatic Polymerization of Phosphonate Nucleosides

P. Herdewijn, M. Renders, A. Holý, 2008, Chembiochem : a European journal of chemical biology.

Enzymatic synthesis of phosphonomethyl oligonucleotides by therminator polymerase.

P. Herdewijn, J. Rozenski, M. Renders, 2007, Angewandte Chemie.

Synthesis of N6‐Alkylated Adenosine Derivatives.

C. Pannecouque, P. Herdewijn, J. Rozenski, 1997 .

Oligonucleotides: Molecular Versions for Optimal use in Vivo

P. Herdewijn, A. Aerschot, E. Saison-Behmoaras, 1996 .

ENANTIOSELECTIVE APPROACH TO THE SYNTHESIS OF CYCLOHEXANE CARBOCYCLIC NUCLEOSIDES

P. Herdewijn, R. Busson, J. Rozenski, 1998 .

The interplay between antiviral activity, oligonucleotide hybridisation and nucleic acids incorporation studies.

P. Herdewijn, 2006, Antiviral research.

Metabolism of the Carbocyclic Analogue of (E)-5-(2-Iodovinyl)-Z'- deoxyuridine in Herpes Simplex Virus-infected Cells

P. Herdewijn, J. Balzarini, R. Bernaerts, 1985 .

Metabolism of the carbocyclic analogue of (E)-5-(2-iodovinyl)-2'-deoxyuridine in herpes simplex virus-infected cells. Incorporation of C-IVDU into DNA.

E. De Clercq, P. Herdewijn, A. Verbruggen, 1985, The Journal of biological chemistry.

Influence of Fluorination of the Sugar Moiety on the Anti-HIV-1 Activity of 2′,3′-Dideoxynucleosides

R. Pauwels, P. Herdewijn, A. Aerschot, 1989 .

Enzymatic synthesis of DNA employing pyrophosphate-linked dinucleotide substrates

P. Herdewijn, Mohitosh Maiti, Xiaoyan Song, 2011 .

INVESTIGATIONS ON SARCOSINE AND ISONIPECOTIC ACID CONTAINING PEPTIDE NUCLEIC ACIDS

P. Herdewijn, C. Hendrix, T. Lescrinier, 1999 .

CYCLOHEXENE NUCLEIC ACIDS (CeNA) FORM STABLE DUPLEXES WITH RNA AND INDUCE RNASE H ACTIVITY

P. Herdewijn, I. Luyten, M. Froeyen, 2001 .

Enantioselective Synthesis and Conformational Analysis of Cyclohexene Carbocyclic Nucleosides

P. Herdewijn, Jing Wang, 1999 .

Synthesis and Pairing Properties of Oligonucleotides Containing 3‐Hydroxy‐4‐hydroxymethyl‐1‐cyclohexanyl Nucleosides

R. Esnouf, P. Herdewijn, R. Busson, 1999 .

A Novel and Enantioselective Approach to the Synthesis of Cyclohexane Carbocyclic Nucleosides Starting from (-)-Carvone

P. Herdewijn, Jing Wang, 1999 .

Application of the Mitsunobu-Type Condensation Reaction to the Synthesis of Phosphonate Derivatives of Cyclohexenyl and Cyclohexanyl Nucleosides

P. Herdewijn, R. Busson, J. Rozenski, 1995 .

Stereocontrolled synthesis of ara-type cyclohexenyl nucleosides.

P. Herdewijn, R. Busson, D. Viña, 2003, The Journal of organic chemistry.

Nonenzymatic template-directed reactions on altritol oligomers, preorganized analogues of oligonucleotides.

L. Orgel, P. Herdewijn, R. Busson, 2000, Chemistry.

Nucleosides modifies pour interference arn

P. Herdewijn, R. Juliano, Jing Wang, 2005 .

Selection of New Sequence‐Selective Unnatural Peptides Binding to Double‐Stranded Deoxyribonucleic Acids (dsDNA) by Means of a Gel‐Retardation Experiment for Library Analysis

P. Herdewijn, R. Busson, J. Rozenski, 2002 .

DNA-Binding Ligands from Peptide Libraries Containing Unnatural Amino Acids

P. Herdewijn, J. Rozenski, R. Eritja, 1998 .

Synthesis and evaluation of hexitol nucleoside congeners as ambiguous nucleosides

P. Herdewijn, A. Aerschot, G. Cristalli, 2007 .

Synthesis and Properties of Aminopropyl Nucleic Acids

P. Herdewijn, R. Busson, J. Rozenski, 2005, Chembiochem : a European journal of chemical biology.

Influence of the incorporation of (S)-9-(3,4-dihydroxybutyl)adenine on the enzymatic stability and base-pairing properties of oligodeoxynucleotides.

A. Van Schepdael, P. Herdewijn, C. Urbanke, 1991, Nucleic acids research.

E. De Clercq, P. Herdewijn, J. Balzarini, 1989, Journal of medicinal chemistry.

Ribavirin Derivatives with a Hexitol Moiety: Synthesis and Antiviral Evaluation

E. De Clercq, P. Herdewijn, R. Busson, 2003, Antiviral chemistry & chemotherapy.

Preface

A. Matsuda, P. Herdewijn, M. Egli, 2012 .

Nucleolipids as Potential Organogelators

P. Herdewijn, H. Rosemeyer, E. Stürenberg, 2007, Nucleosides, nucleotides & nucleic acids.

Aspartic acid based nucleoside phosphoramidate prodrugs as potent inhibitors of hepatitis C virus replication.

P. Herdewijn, J. Rozenski, S. de Jonghe, 2015, Organic & biomolecular chemistry.

5'-Deoxy congeners of 9-(3-amido-3-deoxy-beta-D-xylofuranosyl)-N(6)-cyclopentyladenine: new adenosine A(1) receptor antagonists and inverse agonists.

A. IJzerman, V. Vanheusden, P. Herdewijn, 2002, Journal of medicinal chemistry.

Facile immobilization of DNA using an enzymatic his-tag mimic.

P. Marlière, P. Herdewijn, B. Baron, 2017, Chemical communications.

Crystallization and preliminary X-ray study of the D-altritol oligonucleotide GTGTACAC.

P. Herdewijn, M. Abramov, A. Van Aerschot, 2010, Acta crystallographica. Section F, Structural biology and crystallization communications.

Synthesis and Biological Activity of 3′-Modified 2′-5′ Adenylate Trimers

R. Pauwels, P. Herdewijn, E. Clercq, 1987 .

2′–5′-Oligoadenylates (2–5A) As Mediators of Interferon Action. Synthesis and Biological Activity of New 2–5A Analogues

R. Pauwels, P. Herdewijn, E. Clercq, 1987 .

Synthesis of 2′-5′ Adenylate Trimers Containing 3′-Modified β-D-Xylofuranosyl-Adenine Derivatives at the 2′-End

P. Herdewijn, W. Pfleiderer, K. Ruf, 1987 .

The biolabile 2'-O-pivaloyloxymethyl modification in an RNA helix: an NMR solution structure.

T. Lavergne, P. Herdewijn, J. Vasseur, 2013, Organic & biomolecular chemistry.

Nucleotides. Part. XXXII. Synthesis of 2′–5′ Connected oligonucleotides. Prodrugs for antiviral and antitumoral nucleosides†

P. Herdewijn, E. Clercq, W. Pfleiderer, 1989 .

Nucleotides. Part 31. Modified Oligomeric 2′-5′ A Analogues: Synthesis of 2′-5′ Oligonucleotides with 9-(3′-Azido-3′-deoxy-β-D-xylofuranosyl)adenine and 9-(3′-Amino-3′-deoxy-β-D-xylofuranosyl)adenine as Modified Nucleosides.

P. Herdewijn, W. Pfleiderer, R. Charubala, 1990 .

Oligonucleotides with cyclohexene-nucleoside building blocks: crystallization and preliminary X-ray studies of a left-handed sequence GTGTACAC.

P. Herdewijn, K. Robeyns, L. Van Meervelt, 2005, Acta crystallographica. Section F, Structural biology and crystallization communications.

Crystal structure of double helical hexitol nucleic acids.

Randy J Read, Piet Herdewijn, Luc Van Meervelt, 2002, Journal of the American Chemical Society.

Hydrolytic stability of potential antiviral nucleoside analogues: 3'-substituted 2',3'-dideoxy- and 2',3'-didehydro-2',3'-dideoxyribonucleosides

P. Herdewijn, A. Aerschot, H. Lönnberg, 1990 .

Synthesis and Anti-HIV Evaluation of 2′,3′-Dideoxyribo-5-chloropyrimidine Analogues: Reduced Toxicity of 5-Chlorinated 2′,3′-Dideoxynucleosides.

P. Herdewijn, G. Janssen, A. Aerschot, 1990 .

2'-Azido-2',3'-dideoxythymidine: synthesis and crystal structure of a 2'-substituted dideoxynucleoside.

E. De Clercq, P. Herdewijn, J. Balzarini, 1990, Antiviral Research.

Potentiating effect of ribavirin on the anti-retrovirus activity of 3'-azido-2,6-diaminopurine-2',3'-dideoxyriboside in vitro and in vivo.

E. De Clercq, P. Herdewijn, J. Balzarini, 1989, Antiviral research.

Separation of the anomers and isomers of 2′-deoxyuridine and thymidine by capillary zone electrophoresis

E. Roets, J. Hoogmartens, P. Herdewijn, 1993 .

Direct observation of two cyclohexenyl (CeNA) ring conformations in duplex DNA

P. Herdewijn, K. Robeyns, L. Van Meervelt, 2010, Artificial DNA, PNA & XNA.

Use of RNA in drug design

P. Herdewijn, I. Lagoja, 2007, Expert opinion on drug discovery.

NMR-based conformational analysis of 2',6-disubstituted uridines and antiviral evaluation of new phosphoramidate prodrugs.

P. Herdewijn, J. Neyts, P. Leyssen, 2015, Bioorganic & medicinal chemistry.

Synthesis of Aminopropyl Phosphonate Nucleosides with Purine and Pyrimidine Bases

P. Herdewijn, A. Aerschot, I. Lagoja, 2006 .

Chemical Synthesis of 13C and 15N Labeled Nucleosides

P. Herdewijn, I. Lagoja, 2002 .

Synthesis and stability of oligonucleotides containing acyclic achiral nucleoside analogues with two base moieties.

P. Herdewijn, M. Froeyen, R. Busson, 2004, Organic letters.

Bromovinyluracil nucleoside analogues as antiherpes agents

R. T. Walker, P. Herdewijn, C. Desgranges, 1984 .

Mechanism of cytostatic action of novel 5-(thien-2-yl)- and 5-(furan-2-yl)-substituted pyrimidine nucleoside analogues against tumor cells transfected by the thymidine kinase gene of herpes simplex virus.

E. De Clercq, P. Herdewijn, J. Balzarini, 1994, The Journal of biological chemistry.

Investigation of The Kinetics of Degradation of Hexopyranosylated Cytosine Nucleosides Using Liquid Chromatography

E. Roets, J. Hoogmartens, P. Herdewijn, 2000, Nucleosides, nucleotides & nucleic acids.

Easy Synthesis and Different Conformational Behavior of Purine and Pyrimidine .beta.-D-glycero-Pent-2'-enopyranosyl Nucleosides

P. Herdewijn, N. Blaton, B. Doboszewski, 1995 .

Hexopyranosyl-like oligonucleotides

P. Herdewijn, A. Aerschot, K. Augustyns, 1994 .

In Search of Antiviral Compounds Against the AIDS Virus

R. Pauwels, P. Herdewijn, M. Baba, 1987 .

Some 6-Aza-5-substituted-2′-deoxyuridines Show Potent and Selective Inhibition of Herpes Simplex Virus Type 1 Thymidine Kinase

R. T. Walker, P. Herdewijn, B. Wroblowski, 1998 .

5′-O-Phosphonomethyl-2′,3′-dideoxynucleosides: Synthesis and Anti-HIV Activity.

J. Hoogmartens, P. Herdewijn, R. Busson, 1991 .

Synthesis and conformational analysis of 1,5-anhydro-2,4-dideoxy-D-mannitol nucleosides

P. Herdewijn, R. Busson, I. Luyten, 1999 .

Highly potent and selective inhibition of bovine viral diarrhea virus replication by γ-carboline derivatives.

P. Herdewijn, M. Froeyen, Y. Hashimoto, 2010, Antiviral research.

Nucleotides. Part 34. Synthesis of Modified Oligomeric 2′‐5′A Analogues: Potential Antiviral Agents.

P. Herdewijn, W. Pfleiderer, K. Ruf, 1991 .

Synthesis of 3′-Fluoro-3′-deoxy-N6-cyclopentyladenosine

A. IJzerman, P. Herdewijn, R. Busson, 1994 .

Self-complementary sequence context in mature miRNAs.

Piet Herdewijn, P. Herdewijn, F. Schuit, 2010, Biochemical and biophysical research communications.

Toward Safe Genetically Modified Organisms through the Chemical Diversification of Nucleic Acids

Philippe Marlière, Piet Herdewijn, P. Marlière, 2009, Chemistry & biodiversity.

A Derivate of the Antibiotic Doxorubicin Is a Selective Inhibitor of Dengue and Yellow Fever Virus Replication In Vitro

P. Herdewijn, A. Gamarnik, M. Froeyen, 2010, Antimicrobial Agents and Chemotherapy.

Kinetic analysis of N-alkylaryl carboxamide hexitol nucleotides as substrates for evolved polymerases

Vitor B. Pinheiro, J. Frère, P. Herdewijn, 2019, Nucleic acids research.

Characterization of the Posttranscriptional Modifications in Legionella pneumophila Small‐Subunit Ribosomal RNA

P. Herdewijn, J. Rozenski, J. Anné, 2008, Chemistry & biodiversity.

T. cruzi OligoC-TesT: A Simplified and Standardized Polymerase Chain Reaction Format for Diagnosis of Chagas Disease

P. Herdewijn, J. Dujardin, P. Büscher, 2009, PLoS neglected tropical diseases.

A Simplified and Standardized Polymerase Chain Reaction Format for the Diagnosis of Leishmaniasis

P. Herdewijn, G. Van der Auwera, J. Dujardin, 2008, The Journal of infectious diseases.

Pre-microRNA binding aminoglycosides and antitumor drugs as inhibitors of Dicer catalyzed microRNA processing.

P. Herdewijn, K. Nauwelaerts, Mohitosh Maiti, 2012, Bioorganic & medicinal chemistry letters.

Chimeric siRNAs with chemically modified pentofuranose and hexopyranose nucleotides: altritol-nucleotide (ANA) containing GalNAc–siRNA conjugates: in vitro and in vivo RNAi activity and resistance to 5′-exonuclease

M. Manoharan, P. Herdewijn, M. Egli, 2020, Nucleic acids research.

How does hydroxyl introduction influence the double helical structure: the stabilization of an altritol nucleic acid:ribonucleic acid duplex

P. Herdewijn, J. Šponer, J. Šponer, 2012, Nucleic acids research.

A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects

J. Kjems, P. Herdewijn, J. Wengel, 2010, Nucleic acids research.

Biological effects of hexitol and altritol-modified siRNAs targeting B-Raf.

P. Herdewijn, J. Rozenski, M. Abramov, 2009, European journal of pharmacology.

Inhibition of MDR1 expression with altritol-modified siRNAs

P. Herdewijn, M. Abramov, Dong Xu, 2007, Nucleic acids research.

Increased uptake of antisense oligonucleotides by delivery as double stranded complexes.

Piet Herdewijn, Rudy Juliano, P. Herdewijn, 2004, Biochemical pharmacology.

The crystal structure of the CeNA:RNA hybrid ce(GCGTAGCG):r(CGCUACGC).

P. Herdewijn, L. Van Meervelt, Margriet Ovaere, 2011, Chemistry.

Influence of the incorporation of a cyclohexenyl nucleic acid (CeNA) residue onto the sequence d(CGCGAATTCGCG)

P. Herdewijn, K. Robeyns, L. Van Meervelt, 2007, Nucleic acids research.

Chemical fidelity of an RNA polymerase ribozyme

Kyle V. Butler, P. Herdewijn, E. Kool, 2013 .

Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects

J. Dye, M. Diamond, P. Herdewijn, 2017, The Journal of clinical investigation.

Diagnostic accuracy of a new Leishmania PCR for clinical visceral leishmaniasis in Nepal and its role in diagnosis of disease

P. Herdewijn, S. Rijal, M. Boelaert, 2008, Tropical medicine & international health : TM & IH.

Selective Inhibitors of Cyclin G Associated Kinase (GAK) as Anti-Hepatitis C Agents.

S. Knapp, P. Herdewijn, Lei Chang, 2015, Journal of medicinal chemistry.

Enzymatic Synthesis of Backbone‐Modified Oligonucleotides Using T4 DNA Ligase

P. Herdewijn, M. Renders, Donaat Kestemont, 2019, Current protocols in chemical biology.

A methyl group controls conformational equilibrium in human mitochondrial tRNA(Lys).

Piet Herdewijn, G Ulrich Nienhaus, Mark Helm, 2007, Journal of the American Chemical Society.

Molecular analysis of archived blood slides reveals an atypical human Trypanosoma infection.

P. Herdewijn, V. Jamonneau, M. Koffi, 2008, Diagnostic microbiology and infectious disease.

Inhibition of human immunodeficiency virus type 1 transcription by N-aminoimidazole derivatives.

E. De Clercq, C. Pannecouque, P. Herdewijn, 2007, Virology.

Sliding of HIV-1 reverse transcriptase over DNA creates a transient P pocket – targeting P-pocket by fragment screening

P. Herdewijn, K. Das, D. Schols, 2021, Nature Communications.

Where cone snails and spiders meet: design of small cyclic sodium‐channel inhibitors

D. Craik, P. Herdewijn, S. Heinemann, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Binary genetic cassettes for selecting XNA-templated DNA synthesis in vivo.

P. Marlière, P. Herdewijn, F. Liu, 2013, Angewandte Chemie.

Synthesis and Conformation of Pentopyranoside Nucleoside Phosphonates.

P. Herdewijn, E. Lescrinier, E. Groaz, 2019, The Journal of organic chemistry.

On the enzymatic incorporation of an imidazole nucleotide into DNA.

P. Marlière, P. Herdewijn, F. Levi‐Acobas, 2017, Organic & biomolecular chemistry.

1',5'-Anhydro-L-ribo-hexitol Adenine Nucleic Acids (α-L-HNA-A): Synthesis and Chiral Selection Properties in the Mirror Image World.

P. Herdewijn, M. Froeyen, A. Van Aerschot, 2015, The Journal of organic chemistry.

Chemical evolution of a bacterium's genome.

Philippe Marlière, Piet Herdewijn, Stéphane Cruveiller, 2011, Angewandte Chemie.

Catalysts from synthetic genetic polymers

Vitor B. Pinheiro, Piet Herdewijn, Christopher Cozens, 2014, Nature.

Solution structure of a HNA-RNA hybrid.

R. Esnouf, H. Heus, C. Hilbers, 2000, Chemistry & biology.

1,5-anhydro-2,3-dideoxy-2-(guanin-9-yl)-D-arabino-hexitol

P. Herdewijn, L. Meervelt, R. Declercq, 1996 .

Phosphonates Derivatives of 2′,3′-Dideoxy-2′,3′-didehydro-pentopyranosyl Nucleosides

P. Herdewijn, E. Clercq, B. Doboszewski, 1995 .

Stereospecific synthesis of a pentopyranosyl analogue of d4T monophosphate

P. Herdewijn, J. Rozenski, M. Pérez-Pérez, 1994 .

Random-sequence genetic oligomer pools display an innate potential for ligation and recombination

Benjamin T. Porebski, P. Herdewijn, B. T. Porebski, 2018, eLife.

1,5-Anhydro-2,3-dideoxy-2-(guanin-9-yl)-D-arabino-hexitol.

P. Herdewijn, L. Meervelt, R. Declercq, 2010 .

Formation of a 2‐methyl‐branched fatty aldehyde during peroxisomal α‐oxidation

P. Herdewijn, G. Mannaerts, P. V. Van Veldhoven, 1997 .

PCR Amplification of Base‐Modified DNA

P. Herdewijn, E. Eremeeva, 2018, Current protocols in chemical biology.

A short path synthesis of [13C/15N] multilabeled pyrimidine nucleosides starting from glucopyranose nucleosides.

S. Pochet, P. Herdewijn, J. Rozenski, 2003, The Journal of organic chemistry.

Structure-Function Elucidation of a New α-Conotoxin, Lo1a, from Conus longurionis

P. Herdewijn, J. Tytgat, C. Ulens, 2013, The Journal of Biological Chemistry.

Post-transcriptional modification mapping in the Clostridium acetobutylicum 16S rRNA by mass spectrometry and reverse transcriptase assays

P. Herdewijn, J. Rozenski, J. Anné, 2007, Nucleic acids research.

Radical-induced cyclization of the S-methyl dithiocarbonate of 1,2-O-isopropylidene-α-xylose

P. Herdewijn, A. Aerschot, E. Esmans, 1991 .

A synthetic substrate of DNA polymerase deviating from the bases, sugar, and leaving group of canonical deoxynucleoside triphosphates.

P. Marlière, P. Herdewijn, J. Rozenski, 2013, Chemistry & biology.

Comparison of library screening techniques used in the development of dsDNA ligands.

P. Herdewijn, A. Van Aerschot, P. Chaltin, 2003, Bioorganic & Medicinal Chemistry Letters.

Emimycin and its nucleoside derivatives: Synthesis and antiviral activity.

P. Herdewijn, G. Andrei, R. Snoeck, 2018, European journal of medicinal chemistry.

Poly(2-acrylamido-2-methyl-1-propanamide) (PAMPA): A Neutral, Water-Soluble Synthetic Polymer with Double-Stranded Helix Conformation

R. Esnouf, P. Herdewijn, R. Busson, 2001 .

The kalimantacin/batumin biosynthesis operon encodes a self-resistance isoform of the FabI bacterial target.

G. Volckaert, P. Herdewijn, R. Lavigne, 2010, Chemistry & biology.

Synthetic dsDNA-binding peptides using natural compounds as model

P. Herdewijn, J. Rozenski, A. Aerschot, 2006 .

Gas chromatographic determination of alkyl lysophospholipids after solid-phase extraction from cell culture media.

P. Herdewijn, P. Sandra, J. Coene, 1993, Journal of chromatography.

Capillary GC analysis of alkyl lysophospholipids after derivatization with trimethylsilylbromide

P. Herdewijn, W. Bossche, J. Coene, 1991 .

Design of Bioactive Peptides from Naturally Occurring μ-Conotoxin Structures*

P. Herdewijn, J. Tytgat, S. Peigneur, 2012, The Journal of Biological Chemistry.

Discovery of a new subclass of α-conotoxins in the venom of Conus australis.

P. Herdewijn, J. Tytgat, E. Waelkens, 2014, Toxicon : official journal of the International Society on Toxinology.

Structure, stability and function of 5-chlorouracil modified A:U and G:U base pairs

P. Herdewijn, M. Egli, M. Abramov, 2012, Nucleic acids research.

Analysis of the γ-secretase interactome and validation of its association with tetraspanin-enriched microdomains

B. Strooper, P. Herdewijn, K. Gevaert, 2009, Nature Cell Biology.

2′‐Deoxyribonucleoside Phosphoramidate Triphosphate Analogues as Alternative Substrates for E. coli Polymerase III

P. Marlière, M. Delarue, P. Herdewijn, 2012, Chembiochem : a European journal of chemical biology.

Cryo-EM structures of Doravirine and Rilpivirine with HIV-1 Reverse Transcriptase/DNA Aptamer – Nonnucleoside Inhibitor Resistance by E138K and M184I Mutations

C. Pannecouque, E. Arnold, P. Herdewijn, 2022, bioRxiv.

Molecular Dipstick Test for Diagnosis of Sleeping Sickness

P. Herdewijn, J. Dujardin, P. Büscher, 2006, Journal of Clinical Microbiology.

Polymerase-catalyzed synthesis of DNA from phosphoramidate conjugates of deoxynucleotides and amino acids

P. Marlière, P. Herdewijn, K. Nauwelaerts, 2007, Nucleic acids research.

Synthesis of novel 5-amino-thiazolo[4,5-d]pyrimidines as E. coli and S. aureus SecA inhibitors.

P. Herdewijn, K. Segers, J. Anné, 2011, Bioorganic & medicinal chemistry.

Nanostructures from Synthetic Genetic Polymers

P. Herdewijn, P. Holliger, F. Beuron, 2016, Chembiochem : a European journal of chemical biology.

Helical structure of xylose-DNA.

P. Herdewijn, A. Ceulemans, Amutha Ramaswamy, 2010, Journal of the American Chemical Society.

Conformational and Chiral Selection of Oligonucleotides

P. Herdewijn, M. Froeyen, J. Vasseur, 2007, Chemistry & biodiversity.

Identification of Polyphenol Derivatives as Novel SARS-CoV-2 and DENV Non-Nucleoside RdRp Inhibitors

Dongwei Kang, P. Zhan, Xinyong Liu, 2022, Molecules.

Optimization of Isothiazolo[4,3- b]pyridine-Based Inhibitors of Cyclin G Associated Kinase (GAK) with Broad-Spectrum Antiviral Activity.

J. Dye, P. Herdewijn, J. Rozenski, 2018, Journal of medicinal chemistry.

Complete NMR characterization of lychnose from Stellaria media (L.) Vill.

P. Herdewijn, E. Lescrinier, W. Van den Ende, 2006, Carbohydrate research.

Synthesis and Evaluation of Thymidine-5′-O-monophosphate Analogues as Inhibitors of Mycobacterium tuberculosis Thymidylate Kinase.

Piet Herdewijn, Veerle Vanheusden, Hélène Munier-Lehmann, 2003 .

Conformational Analysis, Solvent-Accessible Surface and Geometric Extent of Inhibitors and Substrates

P. Herdewijn, M. Froeyen, H. D. Winter, 2006 .

Discovery of a Potent, Orally Bioavailable PI4KIIIβ Inhibitor (UCB9608) Able To Significantly Prolong Allogeneic Organ Engraftment in Vivo.

S. Steinbacher, T. Ceska, W. Pitt, 2018, Journal of medicinal chemistry.

Influence of amylovoran production on virulence of Erwinia amylovora and a different amylovoran structure in E. amylovora isolates from Rubus

P. Herdewijn, R. Busson, J. V. Van Beeumen, 2004, European Journal of Plant Pathology.

Vitamin-guanosine monophosphate conjugates for in vitro transcription priming.

P. Marlière, P. Herdewijn, Omprakash Bande, 2020, Chemical communications.

Influence of 4′-Substitution on the Activity of Gemcitabine and Its ProTide Against VZV and SARS-CoV-2

P. Herdewijn, G. Andrei, R. Snoeck, 2020, ACS medicinal chemistry letters.

Interaction of HIV-1 Reverse Transcriptase with Modified Oligonucleotide Primers Containing 2′-O-β-D-Ribofuranosyladenosine

P. Herdewijn, A. Van Aerschot, S. Mikhailov, 2004, Biochemistry (Moscow).

An additional 2'-ribofuranose residue at a specific position of the DNA primer prevents Its elongation by HIV-1 reverse transcriptase.

P. Herdewijn, A. Van Aerschot, S. Kochetkov, 2002, Bioorganic & medicinal chemistry letters.

Incorporation of a minimal nucleotide into DNA

P. Marlière, P. Herdewijn, J. Mahy, 2018, Tetrahedron Letters.

Functional Comparison of Laboratory-Evolved XNA Polymerases for Synthetic Biology.

P. Herdewijn, J. Chaput, Eric J. Yik, 2021, ACS synthetic biology.

Oligonucleotides with ability to inhibit cytomegalovirus

P. Herdewijn, 1996 .

Highly stable hexitol based XNA aptamers targeting the vascular endothelial growth factor

P. Herdewijn, M. Abramov, D. Schols, 2019, Nucleic acids research.

Identification of a peptide inhibitor against glycosomal phosphoglycerate kinase of Trypanosoma brucei by a synthetic peptide library approach.

P. Herdewijn, J. Rozenski, J. V. Van Beeumen, 1995, Bioorganic & medicinal chemistry.

Chemical Etiology of Nucleic Acids: Aminopropyl Nucleic Acids (APNAs)

P. Herdewijn, M. Froeyen, J. Rozenski, 2007, Chemistry & biodiversity.

Synthesis and Structure-Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3- b]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity.

S. Knapp, J. Dye, P. Herdewijn, 2019, Journal of medicinal chemistry.

Design of Bioactive Peptides from Naturally Occurring

P. Herdewijn, J. Tytgat, S. Peigneur, 2012 .

Nonenzymatic synthesis of RNA and DNA oligomers on hexitol nucleic acid templates: the importance of the A structure.

L. Orgel, P. Herdewijn, R. Busson, 1999, Journal of the American Chemical Society.

Structural and Functional Elucidation of Peptide Ts11 Shows Evidence of a Novel Subfamily of Scorpion Venom Toxins

P. Herdewijn, J. Tytgat, J. Cassoli, 2016, Toxins.

Pc16a, the first characterized peptide from Conus pictus venom, shows a novel disulfide connectivity

P. Herdewijn, J. Tytgat, S. Peigneur, 2012, Peptides.

Comparative structural dynamics of Tyrosyl-tRNA synthetase complexed with different substrates explored by molecular dynamics

P. Herdewijn, M. Froeyen, Tong Li, 2008, European Biophysics Journal.

Structure of 1‐(2‐deoxy‐2‐fluoro‐α‐d‐arabinopyranosyl)‐5‐iodouracil

P. Herdewijn, A. Aerschot, N. Blaton, 1991 .

Synthesis of 2′‐O‐β‐d‐Ribofuranosylnucleosides

P. Herdewijn, S. Mikhailov, G. V. Bobkov, 2006, Current protocols in nucleic acid chemistry.

3′-(1,2,3-Triazol-1-yl)-2′,3′-dideoxythymidine and 3′-(1,2,3-Triazol-1-yl)-2′,3′-dideoxyuridine.

P. Herdewijn, A. Aerschot, J. Balzarini, 1990 .

Preface

A. Matsuda, P. Herdewijn, M. Egli, 2010 .

Probing the MvaI Methyltransferase Region that Interacts with DNA: Affinity Labeling with the Dialdehyde-Containing DNA Duplexes

P. Herdewijn, A. Aerschot, S. Mikhailov, 2000, Nucleosides, nucleotides & nucleic acids.

Astemizole analogues with reduced hERG inhibition as potent antimalarial compounds.

Jef Rozenski, Piet Herdewijn, Steve Peigneur, 2017, Bioorganic & medicinal chemistry.

alpha-Amino acids derived from ornithine as building blocks for peptide synthesis.

C. Pannecouque, P. Herdewijn, R. Busson, 2009, The journal of peptide research : official journal of the American Peptide Society.

Base-base interactions in the minor groove of double-stranded DNA.

P. Herdewijn, M. Froeyen, A. Van Aerschot, 2006, The Journal of organic chemistry.

Amino acids derived from ornithine

C. Pannecouque, P. Herdewijn, J. Rozenski, 1995, Letters in Peptide Science.

Disaccharide Nucleosides And Their Enzymatic And Chemical Incorporation Into Oligonucleotides

P. Herdewijn, A. Aerschot, S. Mikhailov, 1998 .

Liquid chromatographic separation of the anomers and isomers of 2′-deoxyuridine

E. Roets, J. Hoogmartens, P. Herdewijn, 1992 .

Disaccharide Nucleosides and Their Enzymatic and Chemical Incorporation into Oligonucleotides.

P. Herdewijn, A. Aerschot, S. Mikhailov, 2010 .

Synthesis of disaccharide nucleosides and their incorporation into oligonucleotides

P. Herdewijn, J. Rozenski, A. Aerschot, 1996 .

Synthesis and Conformational Properties of O-β-D-Ribofuranosyl-(1″-2′)-guanosine and (Adenosine)-5″-phosphate

P. Herdewijn, J. Rozenski, S. Mikhailov, 2003, Nucleosides, nucleotides & nucleic acids.

Synthesis and Properties of O-β-D-ribofuranosyl-(1″2′)-guanosine-5″- O-phosphate and Its Derivatives

P. Herdewijn, J. Rozenski, S. Mikhailov, 2003 .

Synthesis and Properties of O-β-D-Ribofuranosyl-(1″-2′)-Adenosine-5″-O-Phosphate and Its Derivatives

P. Herdewijn, J. Rozenski, I. Luyten, 2000 .

Solution Structure of a RNA Decamer Duplex, Containing 9-[2-O-(beta-D-ribofuranosyl)-beta-D-ribofuranosyl]adenine, a Special Residue in Lower Eukaryotic Initiator tRNAs

R. Esnouf, H. Heus, C. Hilbers, 2000 .

Regioselective incorporation of reactive dialdehyde groups into synthetic oligonucleotides

P. Herdewijn, A. Aerschot, S. Mikhailov, 1996 .

2,3′‐Difluoro‐and 3′‐Azido‐2′‐Fluoro Substituted Dideoxypyrimidines as Potential Anti‐HIV Agents

P. Herdewijn, A. Aerschot, 2010 .

Synthesis of 2',3'-disubstituted 3'-deoxythymidine derivatives

P. Herdewijn, A. Aerschot, 2010 .

Eicar (5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide). A novel potent inhibitor of inosinate dehydrogenase activity and guanylate biosynthesis.

E. De Clercq, P. Herdewijn, J. Balzarini, 1993, The Journal of biological chemistry.

Pseudouridine detection improvement by derivatization with methyl vinyl sulfone and capillary HPLC-mass spectrometry.

P. Herdewijn, J. Rozenski, Gert Emmerechts, 2005, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

The effect of addition of carbon powder to samples in liquid secondary ion mass spectrometry: Improved ionization of apolar compounds

P. Herdewijn, J. Rozenski, 1995 .

Characterization of an HNA aptamer suggests a non-canonical G-quadruplex motif

P. Herdewijn, P. Holliger, D. Christ, 2023, Nucleic acids research.

Effects of six-membered carbohydrate rings on structure, stability, and kinetics of G-quadruplexes.

P. Herdewijn, J. Mergny, A. Bourdoncle, 2013, Chemistry.

Hexitol nucleic acid-containing aptamers are efficient ligands of HIV-1 TAR RNA.

J. Toulmé, P. Herdewijn, A. Van Aerschot, 2005, Biochemistry.

Scalable Synthesis, In Vitro cccDNA Reduction, and In Vivo Antihepatitis B Virus Activity of a Phosphonomethoxydeoxythreosyl Adenine Prodrug.

R. Ptak, P. Herdewijn, M. Luo, 2020, Journal of medicinal chemistry.

Synthesis of a Pyridoxine–Peptide Based Delivery System for Nucleotides

P. Herdewijn, R. Busson, A. Marchand, 2007, Chemistry & biodiversity.

In vitro disposition profiling of heterocyclic compounds.

P. Herdewijn, P. Annaert, P. Augustijns, 2015, International journal of pharmaceutics.

Structures of 1-(2,3-dideoxy-erythro-α-D-hexopyranosyl)thymine and the 1-(2,3-dideoxy-erythro-β-D-hexopyranosyl)thymine.dioxane complex

P. Herdewijn, A. Aerschot, N. Blaton, 1991 .

1-(2,3-Dideoxy-erythro-β-d-hexopyranosyl)cytosine: an example of the conformational and stacking properties of pyranosyl pyrimidine nucleosides. A crystallographic and computational approach

P. Herdewijn, A. Aerschot, N. Blaton, 1992 .

Insight into ligand selectivity in HCV NS5B polymerase: molecular dynamics simulations, free energy decomposition and docking

Piet Herdewijn, Matheus Froeyen, P. Herdewijn, 2010, Journal of molecular modeling.

Regioselective 2′-O-Debenzoylation of 2′,3′-Di-O-benzoyl Threose Nucleosides.

P. Herdewijn, M. Froeyen, Miyeon Jang, 2013 .

Cleavage of DNA without loss of genetic information by incorporation of a disaccharide nucleoside.

P. Herdewijn, M. Froeyen, R. Busson, 2003, Nucleic acids research.

Synthesis of fluorinated sphinganine and dihydroceramide analogues.

P. Herdewijn, R. Busson, D. Keukeleire, 2000 .

Solution structure and conformational dynamics of deoxyxylonucleic acids (dXNA): an orthogonal nucleic acid candidate.

P. Herdewijn, A. Ceulemans, Amutha Ramaswamy, 2012, Chemistry.

Chemistry and biology of artificial nucleic acids

P. Herdewijn, M. Egli, 2012 .

Polymerase-catalysed incorporation of glucose nucleotides into a DNA duplex.

P. Herdewijn, M. Froeyen, M. Abramov, 2009, Chemistry.

Discovery of 3-phenyl- and 3-N-piperidinyl-isothiazolo[4,3-b]pyridines as highly potent inhibitors of cyclin G-associated kinase.

P. Herdewijn, M. Froeyen, D. Schols, 2021, European journal of medicinal chemistry.

NMR evidence for a novel asparagine‐linked oligosaccharide on cellobiohydrolase I from Trichoderma reesei RUTC 30

P. Herdewijn, A. De Bruyn, M. Maras, 1997, FEBS letters.

Penicilloates derived from penicillanic acid

P. Herdewijn, P. Claes, H. Vanderhaeghe, 1982 .

CRISPR-Cas9 recognition of enzymatically synthesized base-modified nucleic acids

P. Herdewijn, M. Abramov, D. Daelemans, 2023, Nucleic acids research.

Structure-Function Elucidation of a New (cid:2) -Conotoxin, Lo1a, from Conus longurionis

P. Herdewijn, J. Tytgat, C. Ulens, 2014 .

Synthesis and anti-herpes activity of 5-trifluorovinyl-2'-deoxyuridine

P. Herdewijn, E. Clercq, R. Snoeck, 1992 .

Base pairing involving artificial bases in vitro and in vivo

P. Marlière, P. Herdewijn, J. Rozenski, 2015, Chemical Science.

Theoretical Analysis of a Self-Replicator With Reduced Template Inhibition Based on an Informational Leaving Group

P. Herdewijn, Erwan Bigan, H. Mattelaer, 2016, Journal of Molecular Evolution.

Regioselective cross-coupling reactions and nucleophilic aromatic substitutions on a 5,7-dichloropyrido[4,3-d]pyrimidine scaffold

P. Herdewijn, Ling-Jie Gao, S. D. Jonghe, 2006 .

Synthesis and anti-SARS-CoV-2 evaluation of lipid prodrugs of β-D-N4-hydroxycytidine (NHC) and a 3′-fluoro-substituted analogue of NHC

P. Herdewijn, G. Andrei, R. Snoeck, 2023, Bioorganic Chemistry.

The Network of Replication, Transcription, and Reverse Transcription of a Synthetic Genetic Cassette.

P. Herdewijn, M. Abramov, E. Eremeeva, 2020, Angewandte Chemie.

Antimalarial antisense activity of hexitol nucleic acids

M. V. Flores, D. Atkins, T. Stewart, 1999, Parasitology Research.

Synthesis, antiviral activity, and computational study of β-d-xylofuranosyl nucleoside phosphonates.

P. Herdewijn, E. Lescrinier, Yuqing Xu, 2023, European journal of medicinal chemistry.

Synthesis of 9-(3-azido-2,3-dideoxy-β-D--pentofuranosyl)-2,6-diaminopurine (AzddDAP)

P. Herdewijn, A. Aerschot, 1989 .

Cyclin G-associated kinase (GAK) affinity and antiviral activity studies of a series of 3-C-substituted isothiazolo[4,3-b]pyridines.

P. Herdewijn, M. Froeyen, Szu-Yuan Pu, 2019, European journal of medicinal chemistry.

Synthesis and Conformational Analysis of 2′-Deoxy-2′-(3-methoxybenzamido)adenosine, a Rational-Designed Inhibitor of Trypanosomal Glyceraldehyde Phosphate Dehydrogenase (GAPDH).

P. Herdewijn, J. Rozenski, A. Aerschot, 1994 .

Synthesis of 9-(3-Azido-2,3-dideoxy-β-D-erythro-pentofuranosyl)-2,6-diaminopurine (AzddDAP) (I).

P. Herdewijn, A. Aerschot, 1989 .

Molecular analysis of archived blood slides reveals an atypical human Trypanosoma infection.

P. Herdewijn, V. Jamonneau, M. Koffi, 2008, Diagnostic microbiology and infectious disease.

Modulation of the tetrameric I-motif folding of C-rich Tetrahymena telomeric sequences by hexitol nucleic acid (HNA) modifications.

P. Herdewijn, C. Sissi, L. Grigoletto, 2023, Biochimie.

Substrate based peptide aldehyde inhibits bacterial type I signal peptidase.

P. Herdewijn, J. Anné, Katrijn Bockstael, 2009, Bioorganic & medicinal chemistry letters.

Synthesis of novel 5-amino-thiazolo[4,5-d]pyrimidines as E. coli and S. aureus SecA inhibitors.

P. Herdewijn, K. Segers, J. Anné, 2011, Bioorganic & medicinal chemistry.

Full Pre‐Steady‐State Kinetic Analysis of Single Nucleotide Incorporation by DNA Polymerases

J. Frère, P. Herdewijn, D. Toye, 2019, Current Protocols in Nucleic Acid Chemistry.

The Twentieth International Conference on Antiviral Research

Debasish, Pierre, P. Herdewijn, 2007, Antiviral Research.

Synthesis of a C-Nucleoside Phosphonate by Base-Promoted Epimerization.

P. Herdewijn, E. Lescrinier, Pengju Nie, 2018, Organic letters.

Chemical Morphing of DNA Containing Four Noncanonical Bases.

P. Marlière, P. Herdewijn, J. Rozenski, 2016, Angewandte Chemie.

Biological activity of hexitol nucleic acids targeted at Ha-ras and intracellular adhesion molecule-1 mRNA.

J Geysen, P. Herdewijn, J. Geysen, 2000, Biochemical pharmacology.

Incorporation of Amino Acids with Long-Chain Terminal Olefins into Proteins

P. Herdewijn, N. Budisa, J. Rademann, 2016, Molecules.

NMR study on the interaction of the conserved CREX 'stem-loop' in the Hepatitis E virus genome with a naphthyridine-based ligand.

P. Herdewijn, M. Froeyen, M. Abramov, 2015, Organic & biomolecular chemistry.

Contribution of dihydrouridine in folding of the D-arm in tRNA.

B Nawrot, P. Herdewijn, B. Nawrot, 2015, Organic & biomolecular chemistry.

Structure Determination of the Top‐Loop of the Conserved 3′‐Terminal Secondary Structure in the Genome of Flaviviruses

Roger A. Jones, P. Herdewijn, N. Dyubankova, 2010, Chembiochem : a European journal of chemical biology.

Overcoming the membrane barrier: Recruitment of γ-glutamyl transferase for intracellular release of metabolic cargo from peptide vectors.

P. Marlière, S. Panke, P. Herdewijn, 2017, Metabolic engineering.

RNA as a target for drug design, the example of Tat-TAR interaction.

P. Herdewijn, M. Froeyen, 2002, Current topics in medicinal chemistry.

Hadamard 1D 1H TOCSY and its application to oligosaccharides

R. Contreras, P. Herdewijn, A. De Bruyn, 1997 .

New dsDNA binding unnatural oligopeptides with pyrimidine selectivity.

P. Herdewijn, R. Busson, J. Rozenski, 2002, Bioorganic & medicinal chemistry.

Design of Bioactive Peptides from Naturally Occurring μ-Conotoxin Structures*

P. Herdewijn, J. Tytgat, S. Peigneur, 2012, The Journal of Biological Chemistry.

Crystallographic analysis of engineered polymerases synthesizing phosphonomethylthreosyl nucleic acid

P. Herdewijn, N. Chim, J. Chaput, 2022, Nucleic acids research.

Synthesis and Antiviral Activities of Some New 5-Heteroaromatic Substituted Derivatives of 2′-Deoxyuridine

C. Pannecouque, P. Herdewijn, A. Aerschot, 1995 .

Nucleic acids with a six-membered carbohydrate mimic and RNA interference.

P. Herdewijn, R. Juliano, 2007, Blood cells, molecules & diseases.

Structure of a nucleoside analogue, 3'-deoxy-2'-fluorothymidine

P. Herdewijn, A. Aerschot, N. Blaton, 1990 .

A neural network for predicting the stability of RNA/DNA hybrid duplexes

P. Herdewijn, Yufen Zhao, Chang-mei Cheng, 2004 .

Molecular Dynamics of Double Stranded Xylo-Nucleic Acid.

P. Herdewijn, A. Ceulemans, Amutha Ramaswamy, 2017, Journal of chemical theory and computation.

Discovery of an Acyclic Nucleoside Phosphonate that Inhibits Mycobacterium tuberculosis ThyX Based on the Binding Mode of a 5‐Alkynyl Substrate Analogue

P. Herdewijn, M. Froeyen, J. Rozenski, 2013, ChemMedChem.

Preparation of Guanine and Diaminopurine from Biuret. Part III

P. Herdewijn, I. Lagoja, 2007, Chemistry & biodiversity.

Synthesis and Activity of Oligonucleotides Containing a Biologically Active Nucleoside at the 2′End

R. Pauwels, P. Herdewijn, E. Clercq, 1987 .

Peptidoglycan glycosyltransferase-ligand binding assay based on tryptophan fluorescence quenching.

P. Herdewijn, A. Matagne, M. Terrak, 2018, Biochimie.

Welcome Home, Systems Chemists!

P. Herdewijn, S. Otto, G. von Kiedrowski, 2010 .