J. Sacchettini

发表

Altered NADH/NAD+ Ratio Mediates Coresistance to Isoniazid and Ethionamide in Mycobacteria

C. Vilchèze, T. Weisbrod, Bing Chen, 2005, Antimicrobial Agents and Chemotherapy.

Crystal structures of soybean beta-amylase reacted with beta-maltose and maltal: active site components and their apparent roles in catalysis.

J. Sacchettini, B. Mikami, M. Degano, 1994, Biochemistry.

Crystal structures of soybean beta-amylase reacted with beta-maltose and maltal: active site components and their apparent roles in catalysis.

J. Sacchettini, B. Mikami, M. Degano, 1994 .

Redefining the role of the quaternary shift in Bacillus stearothermophilus phosphofructokinase.

J. Sacchettini, Rockann E. Mosser, M. Reddy, 2013, Biochemistry.

The TB Structural Genomics Consortium: a decade of progress.

D. Eisenberg, M. James, J. Sacchettini, 2011, Tuberculosis.

Crystal structure of kappa-bungarotoxin at 2.3-A resolution.

J. Sacchettini, J. Dewan, G. A. Grant, 1994, Biochemistry.

Crystal Structure of Circadian Clock Protein KaiA from Synechococcus elongatus*

Thomas R Ioerger, James C Sacchettini, Sheng Ye, 2004, Journal of Biological Chemistry.

Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.

J. Sacchettini, W. Jacobs, G. A. Grant, 1998, Science.

Crystal Structure of the Mycobacterium tuberculosis Enoyl-ACP Reductase, InhA, in Complex with NAD+ and a C16 Fatty Acyl Substrate*

C. Vilchèze, J. Sacchettini, R. Bittman, 1999, The Journal of Biological Chemistry.

Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection

M. Chase, J. Galagan, M. Lipsitch, 2011, Nature Genetics.

Binding Mechanism of the N-Terminal SH3 Domain of CrkII and Proline-Rich Motifs in cAbl.

J. Sacchettini, I. Krieger, V. Bhatt, 2016, Biophysical journal.

Advances in Active Libraries and Generic Programming Methods , Techniques , and Language Features

J. Sacchettini, T. Ioerger, Jaakko Järvi, 2009 .

Identification of New Drug Targets and Resistance Mechanisms in Mycobacterium tuberculosis

D. Sherman, J. Sacchettini, T. Ioerger, 2013, PloS one.

Regulation of a muralytic enzyme by dynamic membrane topology

J. Sacchettini, Qingan Sun, Gabriel F Kuty, 2009, Nature Structural &Molecular Biology.

Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid

C. Vilchèze, T. Weisbrod, L. Kremer, 2006, Nature Medicine.

CsoR is a novel Mycobacterium tuberculosis copper-sensing transcriptional regulator.

Tong Liu, James C Sacchettini, Graham N George, 2007, Nature chemical biology.

Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing

Thomas R. Ioerger, Curtis Huttenhower, James C. Sacchettini, 2013, Cell.

Structural insight into pH-induced conformational changes within the native human transthyretin tetramer.

James C Sacchettini, J. Sacchettini, J. Kelly, 2008, Journal of molecular biology.

Discovery of novel nitrobenzothiazole inhibitors for Mycobacterium tuberculosis ATP phosphoribosyl transferase (HisG) through virtual screening.

Thomas R Ioerger, James C Sacchettini, J. Sacchettini, 2008, Journal of medicinal chemistry.

Global Assessment of Genomic Regions Required for Growth in Mycobacterium tuberculosis

Thomas R. Ioerger, Curtis Huttenhower, James C. Sacchettini, 2012, PLoS pathogens.

A new function for a common fold: the crystal structure of quinolinic acid phosphoribosyltransferase.

J C Sacchettini, C. Grubmeyer, J. Sacchettini, 1997, Structure.

Mycobacterium tuberculosis Dihydrofolate Reductase Is Not a Target Relevant to the Antitubercular Activity of Isoniazid

C. Vilchèze, Feng Wang, D. Alland, 2010, Antimicrobial Agents and Chemotherapy.

Rational design of potent human transthyretin amyloid disease inhibitors

James C. Sacchettini, H. M. Petrassi, T. Klabunde, 2000, Nature Structural Biology.

Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis.

James C Sacchettini, J. Sacchettini, J. Kelly, 2004, Journal of medicinal chemistry.

Electronic Reprint Biological Crystallography Phenix: Building New Software for Automated Crystallographic Structure Determination Biological Crystallography Phenix: Building New Software for Automated Crystallographic Structure Determination

Randy J Read, Nicholas K Sauter, Thomas C Terwilliger, 2022 .

An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance.

C. Bogardus, P. Bennett, W. Knowler, 1995, The Journal of clinical investigation.

Improvement of the novel inhibitor for Mycobacterium enoyl-acyl carrier protein reductase (InhA): a structure–activity relationship study of KES4 assisted by in silico structure-based drug screening

H. Sakamoto, J. Sacchettini, F. Berenger, 2020, The Journal of Antibiotics.

Identification of a novel class of small compounds with anti-tuberculosis activity by in silico structure-based drug screening

H. Sakamoto, J. Sacchettini, S. Aoki, 2017, The Journal of Antibiotics.

Discovery of InhA inhibitors with anti-mycobacterial activity through a matched molecular pair approach.

H. Sakamoto, J. Sacchettini, S. Aoki, 2015, European journal of medicinal chemistry.

Structural analysis of substrate and effector binding in Mycobacterium tuberculosis D-3-phosphoglycerate dehydrogenase.

J. Sacchettini, S. Dey, G. A. Grant, 2008, Biochemistry.

The Effect of Hinge Mutations on Effector Binding and Domain Rotation in Escherichia coli D-3-Phosphoglycerate Dehydrogenase*

J. Sacchettini, S. Dey, G. A. Grant, 2007, Journal of Biological Chemistry.

Crystal Structure of Mycobacterium tuberculosis D-3-Phosphoglycerate Dehydrogenase

Sanghamitra Dey, James C Sacchettini, J. Sacchettini, 2005, Journal of Biological Chemistry.

Crystal structure of the human 20S proteasome in complex with carfilzomib.

J. Sacchettini, Chase Miller, W. Harshbarger, 2015, Structure.

Crystal structure of GyrA intein from Mycobacterium xenopi reveals structural basis of protein splicing

Amalio Telenti, James C. Sacchettini, William R. Jacobs, 1998, Nature Structural Biology.

Disulfide Isomerization After Membrane Release of Its SAR Domain Activates P1 Lysozyme

J. Sacchettini, S. Swanson, D. Struck, 2005, Science.

The Structural Basis of T4 Phage Lysis Control: DNA as the Signal for Lysis Inhibition.

J. Sacchettini, I. Krieger, Jeng-Yih Chang, 2020, Journal of molecular biology.

Therapeutic strategies for human amyloid diseases

James C. Sacchettini, J. Sacchettini, J. Kelly, 2002, Nature Reviews Drug Discovery.

Cocrystal structures of NC6.8 Fab identify key interactions for high potency sweetener recognition: implications for the design of synthetic sweeteners.

Sangeeta Khare, Bernhard Rupp, James C Sacchettini, 2005, Biochemistry.

Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase

James C. Sacchettini, William R. Jacobs, David G. Russell, 2000, Nature.

Refinement of the structure of Escherichia coli-derived rat intestinal fatty acid binding protein with bound oleate to 1.75-A resolution. Correlation with the structures of the apoprotein and the protein with bound palmitate.

J. Gordon, J. Sacchettini, G. Scapin, 1992, The Journal of biological chemistry.

Identification of a type III thioesterase reveals the function of an operon crucial for Mtb virulence.

Feng Wang, J. Sacchettini, R. Langley, 2007, Chemistry & biology.

GWAS for quantitative resistance phenotypes in Mycobacterium tuberculosis reveals resistance genes and regulatory regions

Matthew W. Snyder, J. Shendure, S. Sunyaev, 2019, Nature Communications.

CinA mediates multidrug tolerance in Mycobacterium tuberculosis

J. Sacchettini, D. Schnappinger, I. Krieger, 2022, Nature Communications.

Structural Insights into Mycobacterium tuberculosis Rv2671 Protein as a Dihydrofolate Reductase Functional Analogue Contributing to para-Aminosalicylic Acid Resistance.

J. Sacchettini, Yu-Shan Cheng, 2016, Biochemistry.

Structural Insights into the Mechanism of the Allosteric Transitions of Mycobacterium tuberculosis cAMP Receptor Protein*

J. Sacchettini, M. Reddy, J. Bruning, 2009, The Journal of Biological Chemistry.

MmpL3 Is the Cellular Target of the Antitubercular Pyrrole Derivative BM212

J. Sacchettini, T. Ioerger, M. Botta, 2011, Antimicrobial Agents and Chemotherapy.

The structure and function of the isoniazid target in M. tuberculosis.

J. Sacchettini, J. Blanchard, 1996, Research in microbiology.

The mouse intestinal fatty acid binding protein gene: nucleotide sequence, pattern of developmental and regional expression, and proposed structure of its protein product.

J. Gordon, J. Sacchettini, S. Cohn, 1992, DNA and cell biology.

Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines

T. Klabunde, G. Besra, J. Sacchettini, 2000, Nature Structural Biology.

Natural product inhibitors of fatty acid biosynthesis: synthesis of the marine microbial metabolites pseudopyronines A and B and evaluation of their anti-infective activities

Feng Wang, J. Sacchettini, R. Perozzo, 2008 .

High‐Throughput Differentiation and Screening of a Library of Mutant Stem Cell Clones Defines New Host‐Based Genes Involved in Rabies Virus Infection

J. Sacchettini, T. Ioerger, D. Wallis, 2015, Stem cells.

Regulation of product chain length by isoprenyl diphosphate synthases.

J C Sacchettini, J. Sacchettini, C. Poulter, 1996, Proceedings of the National Academy of Sciences of the United States of America.

DRIP150 Coactivation of Estrogen Receptor α in ZR-75 Breast Cancer Cells Is Independent of LXXLL Motifs*

J. Sacchettini, S. Safe, Jeongeun Lee, 2005, Journal of Biological Chemistry.

Comparison of transposon and deletion mutants in Mycobacterium tuberculosis: The case of rv1248c, encoding 2-hydroxy-3-oxoadipate synthase.

J. Sacchettini, T. Ioerger, C. Nathan, 2015, Tuberculosis.

An engineered transthyretin monomer that is nonamyloidogenic, unless it is partially denatured.

H. M. Petrassi, J. Sacchettini, J. Kelly, 2001, Biochemistry.

Mutations in pepQ Confer Low-Level Resistance to Bedaquiline and Clofazimine in Mycobacterium tuberculosis

Koen Andries, Thomas Ioerger, J. Sacchettini, 2016, Antimicrobial Agents and Chemotherapy.

Mutations in Rv2983 as a novel determinant of resistance to nitroimidazole drugs in Mycobacterium tuberculosis

J. Sacchettini, T. Ioerger, Dalin Rifat, 2018, bioRxiv.

Benzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of action.

J. Sacchettini, J. Kelly, K. Chiang, 2003, Angewandte Chemie.

Improved Phenoxyalkylbenzimidazoles with Activity against Mycobacterium tuberculosis Appear to Target QcrB

P. Hipskind, J. Sacchettini, T. Ioerger, 2017, ACS infectious diseases.

X-ray crystal structure of the soybean agglutinin cross-linked with a biantennary analog of the blood group I carbohydrate antigen.

J. Sacchettini, C. F. Brewer, S. Sabesan, 1995, Biochemistry.

Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis

Sujata Sharma, J. Sacchettini, W. Jacobs, 2000, Nature Structural Biology.

Identifying non-crystallographic symmetry in protein electron-density maps: a feature-based approach.

J. Sacchettini, T. Ioerger, R. Pai, 2006, Acta crystallographica. Section D, Biological crystallography.

Crystal structure of Mycobacterium tuberculosis LrpA, a leucine‐responsive global regulator associated with starvation response

J. Sacchettini, W. Jacobs, T. Ioerger, 2007, Protein science : a publication of the Protein Society.

High Resolution Crystal Structures of Mycobacterium tuberculosis Adenosine Kinase INSIGHTSINTOTHEMECHANISMANDSPECIFICITYOFTHISNOVEL PROKARYOTICENZYME

J. Sacchettini, M. Reddy, S. Palaninathan, 2007 .

Crystal structure of precorrin-8x methyl mutase.

Ding Li, J. Sacchettini, L. Shipman, 2001, Structure.

In Vitro and In Vivo Inhibition of the Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT by Amidinoureas

J. Sacchettini, J. Vendôme, V. Feher, 2022, Journal of medicinal chemistry.

Structural insights into phosphopantetheinyl hydrolase PptH from Mycobacterium tuberculosis

J. Sacchettini, C. Nathan, J. Mosior, 2019, Protein science : a publication of the Protein Society.

A strategy for dual inhibition of the proteasome and fatty acid synthase with belactosin C-orlistat hybrids.

Jeffrey W. Smith, J. Sacchettini, S. Sieber, 2017, Bioorganic & medicinal chemistry.

Functional Genomics Screening Utilizing Mutant Mouse Embryonic Stem Cells Identifies Novel Radiation-Response Genes

J. Sacchettini, T. Ioerger, D. Wallis, 2015, PloS one.

Advancing Translational Science for Pulmonary Nontuberculous Mycobacterial Infections. A Road Map for Research

J. Sacchettini, S. Holland, R. Coler, 2019, American journal of respiratory and critical care medicine.

Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis

J. Sacchettini, I. Krieger, A. Steyn, 2020, Nature Communications.

MHC class I-peptide interactions and TCR recognition.

J. Sacchettini, S. Nathenson, W. Zhang, 1995, Cancer surveys.

Improving amino-acid identification, fit and C(alpha) prediction using the Simplex method in automated model building.

J. Sacchettini, T. Ioerger, T. Romo, 2006, Acta crystallographica. Section D, Biological crystallography.

Thiacetazone, an Antitubercular Drug that Inhibits Cyclopropanation of Cell Wall Mycolic Acids in Mycobacteria

G. Besra, L. Kremer, J. Sacchettini, 2007, PloS one.

High-Throughput Sequencing Enhanced Phage Display Identifies Peptides

J. Sacchettini, T. Ioerger, L. Gresh, 2013 .

Minocycline and Silver Dual-Loaded Polyphosphoester-Based Nanoparticles for Treatment of Resistant Pseudomonas aeruginosa.

J. Sacchettini, K. Wooley, P. Shah, 2019, Molecular pharmaceutics.

Crystal Structure of Rsr, an Ortholog of the Antigenic Ro Protein, Links Conformational Flexibility to RNA Binding Activity*

J. Sacchettini, A. Holzenburg, A. Ramesh, 2007, Journal of Biological Chemistry.

Structural and functional insight into the Mycobacterium tuberculosis protein PrpR reveals a novel type of transcription factor

S. Fortune, J. Sacchettini, Nathan D Hicks, 2019, Nucleic acids research.

R pyocin tail fiber structure reveals a receptor-binding domain with a lectin fold.

J. Sacchettini, Jennifer H C Tsai, A. J. Salazar, 2019 .

Microsoft Word-JBC_final_revision1.docx

Feng Wang, J. Sacchettini, T. Ioerger, 2013 .

TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities

M. Chase, S. Fortune, J. Sacchettini, 2018, PLoS pathogens.

Multidrug-Resistant Tuberculosis in Panama Is Driven by Clonal Expansion of a Multidrug-Resistant Mycobacterium tuberculosis Strain Related to the KZN Extensively Drug-Resistant M. tuberculosis Strain from South Africa

J. Sacchettini, T. Ioerger, P. Karakousis, 2013, Journal of Clinical Microbiology.

The Tuberculosis Drug Accelerator at year 10: what have we learned?

H. M. Petrassi, Christopher B. Cooper, Robert H Bates, 2021, Nature Medicine.

Selective Inactivity of Pyrazinamide against Tuberculosis in C3HeB/FeJ Mice Is Best Explained by Neutral pH of Caseum

J. Sacchettini, T. Ioerger, V. Dartois, 2015, Antimicrobial Agents and Chemotherapy.

Hydrogen peroxide-mediated isoniazid activation catalyzed by Mycobacterium tuberculosis catalase-peroxidase (KatG) and its S315T mutant.

Feng Wang, J. Sacchettini, Hong-Xiu Yu, 2006, Biochemistry.

Human intestinal fatty acid binding protein: report of an assay with studies in normal volunteers and intestinal ischemia.

J. Sacchettini, W. Marks, C. Marks, 1997, Surgery.

Elevated intestinal fatty acid binding protein and gastrointestinal complications following cardiopulmonary bypass: a preliminary analysis.

R. A. Hall, J. Sacchettini, W. Marks, 2001, The Journal of surgical research.

Crystal Structure of M. tuberculosis SecA, A Preprotein Translocating ATPase

J. Sacchettini, M. Braunstein, D. Ronning, 2003 .

Evolutionary relationships and functional conservation among vertebrate Max-associated proteins: the zebra fish homolog of Mxi1.

L. Chin, R. DePinho, J. Sacchettini, 1994, Oncogene.

Biochemical and Genetic Analyses of Murine Hepatitis Virus Nsp 15 Endoribonuclease

J. Sacchettini, K. Bhardwaj, C. Kao, 2007 .

Biochemical and Genetic Analyses of Murine Hepatitis Virus Nsp15 Endoribonuclease

J. Sacchettini, K. Bhardwaj, C. Kao, 2007, Journal of Virology.

Development of single-cell-level microfluidic technology for long-term growth visualization of living cultures of Mycobacterium smegmatis

J. Sacchettini, A. Han, Song‐I Han, 2021, Microsystems & nanoengineering.

D-3-Phosphoglycerate Dehydrogenase from Mycobacterium tuberculosis Is a Link between the Escherichia coli and Mammalian Enzymes*

J. Sacchettini, S. Dey, G. A. Grant, 2005, Journal of Biological Chemistry.

A Sec14-like phosphatidylinositol transfer protein paralog defines a novel class of heme-binding proteins

J. Sacchettini, A. Laganowsky, J. Patrick, 2020, eLife.

A Sec14-like Phosphatidylinositol Transfer Protein Paralog Defines a Novel Class of Heme-binding Proteins With An Unusual Heme Coordination Mechanism

J. Sacchettini, A. Laganowsky, J. Patrick, 2020, bioRxiv.

High throughput crystallography of TB drug targets.

D. Eisenberg, J. Berger, M. James, 2007, Infectious disorders drug targets.

Genome-wide Phenotypic Profiling Identifies and Categorizes Genes Required for Mycobacterial Low Iron Fitness

J. Sacchettini, T. Ioerger, E. Rubin, 2019, Scientific Reports.

A vitamin B12 transporter in Mycobacterium tuberculosis

Č. Venclovas, J. Sacchettini, T. Ioerger, 2013, Open Biology.

Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an α -glucan pathway

Z. Liu, G. Besra, J. Sacchettini, 2012 .

Binding of fatty acids and peroxisome proliferators to orthologous fatty acid binding proteins from human, murine, and bovine liver.

J. Sacchettini, F. Spener, C. Wolfrum, 2000, Biochemistry.

Mechanism-based inactivator of isocitrate lyases 1 and 2 from Mycobacterium tuberculosis

A. S. Murkin, P. Tyler, J. Sacchettini, 2017, Proceedings of the National Academy of Sciences.

A collagenolytic serine protease with trypsin-like specificity from the fiddler crab Uca pugilator.

J. Sacchettini, G. A. Grant, H. Welgus, 1983, Biochemistry.

Crystal structure of the major histocompatibility complex class I H-2Kb molecule containing a single viral peptide: implications for peptide binding and T-cell receptor recognition.

J. Sacchettini, S. Nathenson, M. Imarai, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Rapid in vitro assembly of class I major histocompatibility complex

R. Angeletti, N. Papadopoulos, J. Sacchettini, 1995 .

Structural anatomy of Protein Kinase C C1 domain interactions with diacylglycerol and other agonists

J. Sacchettini, T. Igumenova, I. Krieger, 2022, Nature Communications.

Crystal Structure of Lyme Disease Variable Surface Antigen VlsE of Borrelia burgdorferi *

T. Klabunde, J. Sacchettini, Vivek Sharma, 2002, The Journal of Biological Chemistry.

Primary structure and binding characteristics of locust and human muscle fatty-acid-binding proteins.

J. Sacchettini, M. Degano, J. Veerkamp, 1994, European journal of biochemistry.

Crystal Structures of Mycolic Acid Cyclopropane Synthases fromMycobacterium tuberculosis *

James C Sacchettini, Chih-chin Huang, M. Glickman, 2002, The Journal of Biological Chemistry.

Deletion of SenX3-RegX3, a key two-component regulatory system of Mycobacterium smegmatis, results in growth defects under phosphate-limiting conditions.

J. Sacchettini, T. Ioerger, P. Carroll, 2012, Microbiology.

Construction of an overexpression library for Mycobacterium tuberculosis

A. Korkegian, J. Sacchettini, Hongye Li, 2018, Biology methods & protocols.

Ein antibakterielles β‐Lacton bekämpft Mycobacterium tuberculosis durch Infiltration der Mykolsäurebiosynthese

T. Akopian, J. Sacchettini, S. Sieber, 2018 .

An Antibacterial β-Lactone Kills Mycobacterium tuberculosis by Disrupting Mycolic Acid Biosynthesis.

T. Akopian, J. Sacchettini, S. Sieber, 2018, Angewandte Chemie.

Differential Solvation of “Core” Trimannoside Complexes of the Dioclea grandiflora Lectin and Concanavalin A Detected by Primary Solvent Isotope Effects in Isothermal Titration Microcalorimetry*

J. Sacchettini, T. Dam, S. Oscarson, 1998, The Journal of Biological Chemistry.

Altered NADH/NAD (cid:1) Ratio Mediates Coresistance to Isoniazid and Ethionamide in Mycobacteria

C. Vilchèze, T. Weisbrod, L. Kremer, 2005 .

Trypanosomal nucleoside hydrolase. A novel mechanism from the structure with a transition-state inhibitor.

V. Schramm, S. Almo, J. Sacchettini, 1998, Biochemistry.

13C NMR studies of fatty acid-protein interactions: comparison of homologous fatty acid-binding proteins produced in the intestinal epithelium

J. Gordon, J. Sacchettini, D. Cistola, 2004, Molecular and Cellular Biochemistry.

The gelatinolytic activity of rat uterus collagenase.

J. Sacchettini, G. A. Grant, H. Welgus, 1985, The Journal of biological chemistry.

Synthesis and biological activity of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 2: 2'-substituted triclosan derivatives.

Joel S. Freundlich, D. Fidock, J. Sacchettini, 2006, Bioorganic & medicinal chemistry letters.

Crystal structure of a plant catechol oxidase containing a dicopper center

James C. Sacchettini, T. Klabunde, J. Sacchettini, 1998, Nature Structural Biology.

Catechol oxidase - structure and activity.

J. Sacchettini, B. Krebs, C. Eicken, 1999, Current opinion in structural biology.

Crystal structure of orotate phosphoribosyltransferase.

C. Grubmeyer, J. Sacchettini, G. Scapin, 1994, Biochemistry.

Novel diaryl ureas with efficacy in a mouse model of malaria.

Sean Ekins, Joel S. Freundlich, James C Sacchettini, 2013, Bioorganic & medicinal chemistry letters.

Mechanism of thioamide drug action against tuberculosis and leprosy

James C. Sacchettini, William R. Jacobs, Gulcin Gulten, 2007, The Journal of experimental medicine.

Structure of Apo- and Monometalated Forms of NDM-1—A Highly Potent Carbapenem-Hydrolyzing Metallo-β-Lactamase

Gyorgy Babnigg, Youngchang Kim, Robert Jedrzejczak, 2011, PloS one.

Inosine-uridine nucleoside hydrolase from Crithidia fasciculata. Genetic characterization, crystallization, and identification of histidine 241 as a catalytic site residue.

V. Schramm, J. Sacchettini, M. Degano, 1996, Biochemistry.

Crystal structure of quinolinic acid phosphoribosyltransferase from Mmycobacterium tuberculosis: a potential TB drug target.

J C Sacchettini, C. Grubmeyer, J. Sacchettini, 1998, Structure.

Locations and functional roles of conserved lysine residues in Salmonella typhimurium orotate phosphoribosyltransferase.

C. Grubmeyer, J. Sacchettini, G. Scapin, 1995, Biochemistry.

TB drug discovery: addressing issues of persistence and resistance.

Vivek Sharma, James C Sacchettini, J. Sacchettini, 2004, Tuberculosis.

Creating Isoprenoid Diversity

J. Sacchettini, C. Poulter, 1997, Science.

Discovery of Antimicrobial Lipodepsipeptides Produced by a Serratia sp. within Mosquito Microbiomes

J. Sacchettini, J. Clardy, T. Ioerger, 2018, Chembiochem : a European journal of chemical biology.

Expanding the pleuromutilin class of antibiotics by de novo chemical synthesis.

Joel S. Freundlich, J. Sacchettini, I. Krieger, 2011, Chemical science.

Anion-pi Interactions in Computer-Aided Drug Design: Modeling the Inhibition of Malate Synthase by Phenyl-Diketo Acids.

Jill F Ellenbarger, J. Sacchettini, T. Ioerger, 2018 .

Anion-π Interactions in Computer-Aided Drug Design: Modeling the Inhibition of Malate Synthase by Phenyl-Diketo Acids

Steven E Wheeler, Hsiao-Ling Huang, Thomas R Ioerger, 2018, J. Chem. Inf. Model..

Three-dimensional structure of recombinant human muscle fatty acid-binding protein.

J C Sacchettini, J. Sacchettini, G. Scapin, 1994, The Journal of biological chemistry.

Supplemental Information Structure-Guided Discovery of Phenyl-diketo Acids as Potent Inhibitors of M . tuberculosis Malate Synthase

Joel S. Freundlich, Thomas R Ioerger, James C Sacchettini, 2012 .

Structural basis of fumarate hydratase deficiency

K. Kavanagh, J. Sacchettini, W. Yue, 2011, Journal of Inherited Metabolic Disease.

Changes in end-to-end interactions of tropomyosin affect mouse cardiac muscle dynamics.

T. Hewett, D. Zawieja, J. Sacchettini, 2006, American journal of physiology. Heart and circulatory physiology.

Inactivation of the inhA-Encoded Fatty Acid Synthase II (FASII) Enoyl-Acyl Carrier Protein Reductase Induces Accumulation of the FASI End Products and Cell Lysis of Mycobacterium smegmatis

James C. Sacchettini, William R. Jacobs, C. Vilchèze, 2000, Journal of bacteriology.

Triclosan Derivatives: Towards Potent Inhibitors of Drug‐Sensitive and Drug‐Resistant Mycobacterium tuberculosis

Joel S. Freundlich, James C Sacchettini, Joel S Freundlich, 2009, ChemMedChem.

Targeting Tuberculosis and Malaria through Inhibition of Enoyl Reductase

David Alland, Hiroyuki Iwamoto, James C Sacchettini, 2003, Journal of Biological Chemistry.

Kinetic mechanism of human hypoxanthine-guanine phosphoribosyltransferase: rapid phosphoribosyl transfer chemistry.

Yiming Xu, C. Grubmeyer, J. Sacchettini, 1997, Biochemistry.

A Novel Antimycobacterial Compound Acts as an Intracellular Iron Chelator

J. Sacchettini, T. Ioerger, E. Rubin, 2015, Antimicrobial Agents and Chemotherapy.

Drugs versus bugs: in pursuit of the persistent predator Mycobacterium tuberculosis

James C. Sacchettini, Joel S. Freundlich, Eric J. Rubin, 2008, Nature Reviews Microbiology.

Dual role of isocitrate lyase 1 in the glyoxylate and methylcitrate cycles in Mycobacterium tuberculosis

James C Sacchettini, J. Sacchettini, E. Muñoz-Elías, 2006, Molecular microbiology.

Dual inhibition of mycobacterial fatty acid biosynthesis and degradation by 2-alkynoic acids.

James C Sacchettini, Catherine Vilchèze, Robert Bittman, 2006, Chemistry & biology.

X-ray Structural Analysis of Plasmodium falciparum Enoyl Acyl Carrier Protein Reductase as a Pathway toward the Optimization of Triclosan Antimalarial Efficacy*

Joel S. Freundlich, D. Fidock, J. Sacchettini, 2007, Journal of Biological Chemistry.

Structure of the Mtb CarD/RNAP β-lobes complex reveals the molecular basis of interaction and presents a distinct DNA-binding domain for Mtb CarD.

J. Sacchettini, G. Gulten, 2013, Structure.

Expression of rat intestinal fatty acid-binding protein in Escherichia coli. Purification and comparison of ligand binding characteristics with that of Escherichia coli-derived rat liver fatty acid-binding protein.

J B Lowe, J C Sacchettini, J. McQuillan, 1987, The Journal of biological chemistry.

Structural Elucidation of the Specificity of the Antibacterial Agent Triclosan for Malarial Enoyl Acyl Carrier Protein Reductase*

D. Fidock, J. Sacchettini, W. Jacobs, 2002, The Journal of Biological Chemistry.

The 2.0-A resolution structure of soybean beta-amylase complexed with alpha-cyclodextrin.

J. Sacchettini, B. Mikami, E. Hehre, 1993, Biochemistry.

Crystal structure of recombinant farnesyl diphosphate synthase at 2.6-A resolution.

J. Sacchettini, C. Poulter, M. Yan, 1994, Biochemistry.

Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity.

J. Sacchettini, S. Safe, J. Kelly, 2004, Chemistry & biology.

A general method for facilitating heterodimeric pairing between two proteins: application to expression of alpha and beta T-cell receptor extracellular segments.

E. Kawasaki, J. Sacchettini, S. Nathenson, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Ribosomal mutations promote the evolution of antibiotic resistance in a multidrug environment

S. Carr, J. Sacchettini, J. Livny, 2017, eLife.

Mutations in fbiD (Rv2983) as a Novel Determinant of Resistance to Pretomanid and Delamanid in Mycobacterium tuberculosis

J. Sacchettini, T. Ioerger, Dalin Rifat, 2020, Antimicrobial Agents and Chemotherapy.

Expression, purification, and characterization of Escherichia coli dihydrodipicolinate reductase.

J. Sacchettini, S. Reddy, J. Blanchard, 1995, Biochemistry.

Inhibiting transthyretin conformational changes that lead to amyloid fibril formation.

Scott A. Peterson, T. Klabunde, J. Sacchettini, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis and evaluation of the 2,4-diaminoquinazoline series as anti-tubercular agents.

P. Hipskind, J. Sacchettini, T. Ioerger, 2014, Bioorganic & medicinal chemistry.

Perturbation of Cytochrome c Maturation Reveals Adaptability of the Respiratory Chain in Mycobacterium tuberculosis

Jennifer L. Small, J. Sacchettini, T. Ioerger, 2013, mBio.

Crystal structure of Mycobacterium tuberculosis SecA, a preprotein translocating ATPase

J. Sacchettini, W. Jacobs, Vivek Sharma, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Crystal structure of rat intestinal fatty-acid-binding protein. Refinement and analysis of the Escherichia coli-derived protein with bound palmitate.

J C Sacchettini, J. Gordon, J. Sacchettini, 1989, Journal of molecular biology.

Multivalent protein-carbohydrate interactions. A new paradigm for supermolecular assembly and signal transduction.

J. Sacchettini, L. Baum, C. Brewer, 2001, Biochemistry.

The abyssomicin C family as in vitro inhibitors of Mycobacterium tuberculosis.

Joel S. Freundlich, J. Sacchettini, E. Rubin, 2010, Tuberculosis.

Folate pathway disruption leads to critical disruption of methionine derivatives in Mycobacterium tuberculosis.

Joel S. Freundlich, D. Sherman, M. Nixon, 2014, Chemistry & biology.

Crystal Structure of the Lectin from Dioclea grandifloraComplexed with Core Trimannoside of Asparagine-linked Carbohydrates*

J. Sacchettini, D. A. Rozwarski, C. Brewer, 1998, The Journal of Biological Chemistry.

The tuberculosis structural genomics consortium: a structural genomics approach to drug discovery.

J. Sacchettini, T. Ioerger, Tracey L Musa, 2009, Advances in protein chemistry and structural biology.

Crystal structures of Mycobacterium tuberculosis S‐adenosyl‐L‐homocysteine hydrolase in ternary complex with substrate and inhibitors

J. Sacchettini, T. Ioerger, M. Reddy, 2008, Protein science : a publication of the Protein Society.

A Locking Mechanism Regulates RNA Synthesis and Host Protein Interaction by the Hepatitis C Virus Polymerase*

J. Sacchettini, S. Lemon, C. Kao, 2008, Journal of Biological Chemistry.

Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase .

J. Sacchettini, S. Dey, E. Rubin, 2010, Biochemistry.

Subfamily-Specific Adaptations in the Structures of Two Penicillin-Binding Proteins from Mycobacterium tuberculosis

J. Sacchettini, T. Terwilliger, L. Hung, 2014, PloS one.

Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice

J. Sacchettini, Byung-Eun Kim, Vishal M. Gohil, 2020, Science.

TEXTAL™: Automated Crystallographic Protein Structure Determination

Jacob N. Smith, Thomas R. Ioerger, Kreshna Gopal, 2005, AAAI.

TEXTAL system: artificial intelligence techniques for automated protein model building.

Thomas R Ioerger, James C Sacchettini, J. Sacchettini, 2003, Methods in enzymology.

TEXTAL: A Pattern Recognition System for Interpreting Electron Density Maps

Thomas R. Ioerger, James C. Sacchettini, Thomas Holton, 1999, ISMB.

The three-dimensional structure of H-2Db at 2.4 Å resolution: Implications for antigen-determinant selection

J. Sacchettini, S. Nathenson, A. C. Young, 1994, Cell.

Gene-target recognition among members of the Myc superfamily and implications for oncogenesis

Ken Chen, James C. Sacchettini, Ronald A. DePinho, 2000, Nature Genetics.

Refinement of the structure of recombinant rat intestinal fatty acid-binding apoprotein at 1.2-A resolution.

J C Sacchettini, J. Gordon, J. Sacchettini, 1994, The Journal of biological chemistry.

Intracellular fatty-acid-binding proteins and their genes: useful models for diverse biological questions

J. Gordon, J. Sacchettini, K. Roth, 1991 .

Gastrotropin: not an enterooxyntin but a member of a family of cytoplasmic hydrophobic ligand binding proteins.

J. Gordon, J. Sacchettini, L. Banaszak, 1989, The Journal of biological chemistry.

Fatty acid interactions with rat intestinal and liver fatty acid-binding proteins expressed in Escherichia coli. A comparative 13C NMR study.

J. Gordon, J. Sacchettini, L. Banaszak, 1989, The Journal of biological chemistry.

Expression of rat intestinal fatty acid binding protein in E. coli and its subsequent structural analysis: a model system for studying the molecular details of fatty acid-protein interaction

J. Gordon, J. Sacchettini, L. Banaszak, 2004, Molecular and Cellular Biochemistry.

Crystallization of rat cellular retinol binding protein II. Preliminary X-ray data obtained from the apoprotein expressed in Escherichia coli.

J. Gordon, J. Sacchettini, L. Banaszak, 1987, The Journal of biological chemistry.

Charged residue changes in the carboxy‐terminus of α‐tropomyosin alter mouse cardiac muscle contractility

T. Hewett, J. Sacchettini, J. Robbins, 2004, The Journal of physiology.

Structural and Functional Analyses of the Severe Acute Respiratory Syndrome Coronavirus Endoribonuclease Nsp15*

James C. Sacchettini, J. Sacchettini, K. Bhardwaj, 2008, Journal of Biological Chemistry.

Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32

J. Sacchettini, T. Ioerger, E. Rubin, 2013, Proceedings of the National Academy of Sciences.

Structural evidence for a pH-sensitive dilysine trigger in the hen ovotransferrin N-lobe: implications for transferrin iron release.

J. Sacchettini, B. Mikami, J. Dewan, 1993, Biochemistry.

The TB structural genomics consortium: a resource for Mycobacterium tuberculosis biology.

A W Munro, M Wilmanns, E N Baker, 2003, Tuberculosis.

Enzymatic characterization of the target for isoniazid in Mycobacterium tuberculosis.

J C Sacchettini, C. Vilchèze, J. Sacchettini, 1995, Biochemistry.

Mycobacterium tuberculosis Antigen 85A and 85C Structures Confirm Binding Orientation and Conserved Substrate Specificity*

G. Besra, J. Sacchettini, D. Ronning, 2004, Journal of Biological Chemistry.

Aspartate aminotransferase Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis

J. Sacchettini, E. Rubin, K. Rhee, 2019, Nature Communications.

Structures of Mycobacterium tuberculosis FadD10 protein reveal a new type of adenylate-forming enzyme.

Feng Wang, J. Sacchettini, T. Ioerger, 2013, The Journal of Biological Chemistry.

Structures of Mycobacterium tuberculosis FadD10 Protein Reveal a New Type of Adenylate-forming Enzyme*

Feng Wang, J. Sacchettini, T. Ioerger, 2013, The Journal of Biological Chemistry.

Sterilization of granulomas is common in both active and latent tuberculosis despite extensive within-host variability in bacterial killing

JoAnne L. Flynn, Philana Ling Lin, Thomas Ioerger, 2013, Nature Medicine.

Rat heart fatty acid-binding protein is highly homologous to the murine adipocyte 422 protein and the P2 protein of peripheral nerve myelin.

J. Gordon, J. Sacchettini, H. Schulz, 1986, The Journal of biological chemistry.

The structure of crystalline Escherichia coli-derived rat intestinal fatty acid-binding protein at 2.5-A resolution.

J. Gordon, J. Sacchettini, L. Banaszak, 1988, The Journal of biological chemistry.

Escherichia coli-derived rat intestinal fatty acid binding protein with bound myristate at 1.5 A resolution and I-FABPArg106-->Gln with bound oleate at 1.74 A resolution.

J C Sacchettini, J. Gordon, J. Sacchettini, 1994, The Journal of biological chemistry.

Structural studies on human muscle fatty acid binding protein at 1.4 A resolution: binding interactions with three C18 fatty acids.

J. Sacchettini, G. Scapin, J. Veerkamp, 1994, Structure.

Interplay between an ATP-binding cassette F protein and the ribosome from Mycobacterium tuberculosis

J. Sacchettini, H. Gamper, Ya-Ming Hou, 2022, Nature Communications.

Interplay between an ATP-binding cassette F protein and the ribosome from Mycobacterium tuberculosis

J. Sacchettini, H. Gamper, Ya-Ming Hou, 2022, Nature communications.

Novel Inhibitors of InhA Efficiently Kill Mycobacterium tuberculosis under Aerobic and Anaerobic Conditions

James C. Sacchettini, William R. Jacobs, David Alland, 2011, Antimicrobial Agents and Chemotherapy.

Structure-guided design of a potent peptide inhibitor targeting the interaction between CRK and ABL kinase.

J. Sacchettini, I. Krieger, V. Bhatt, 2018, MedChemComm.

Protein determinants of phage T4 lysis inhibition

J. Sacchettini, R. Young, V. Kuznetsov, 2012, Protein science : a publication of the Protein Society.

Effective electron-density map improvement and structure validation on a Linux multi-CPU web cluster: The TB Structural Genomics Consortium Bias Removal Web Service.

Bernhard Rupp, Vinod Reddy, James C Sacchettini, 2003, Acta crystallographica. Section D, Biological crystallography.

Structural studies of class I major histocompatibility complex proteins: insights into antigen presentation

J. Sacchettini, S. Nathenson, A. C. Young, 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Automated structure solution with the PHENIX suite.

Randy J Read, Nicholas K Sauter, Thomas C Terwilliger, 2008, Methods in molecular biology.

NDM‐1, the ultimate promiscuous enzyme: substrate recognition and catalytic mechanism

Youngchang Kim, Andrzej Joachimiak, A. Joachimiak, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents

N. Fotouhi, J. Sacchettini, M. Yusupov, 2023, Cell.

Determining protein structure from electron-density maps using pattern matching.

T Holton, T R Ioerger, J A Christopher, 2000, Acta crystallographica. Section D, Biological crystallography.

1,3-Diarylpyrazolyl-acylsulfonamides Target HadAB/BC Complex in Mycobacterium tuberculosis

G. Drewes, M. Bantscheff, K. Chibale, 2022, ACS infectious diseases.

Biochemical and Structural Studies of Malate Synthase fromMycobacterium tuberculosis *

James C Sacchettini, Andras Miczak, Chih-chin Huang, 2002, The Journal of Biological Chemistry.

Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an alpha-glucan pathway.

G. Besra, J. Sacchettini, W. Jacobs, 2010, Nature chemical biology.

Role of the DinB Homologs Rv1537 and Rv3056 in Mycobacterium tuberculosis

J. Sacchettini, G. Kaplan, V. Mizrahi, 2010, Journal of bacteriology.

Crystal Structure of Mycobacterium tuberculosis Diaminopimelate Decarboxylase, an Essential Enzyme in Bacterial Lysine Biosynthesis*

Bernhard Rupp, James C Sacchettini, Kuppan Gokulan, 2003, The Journal of Biological Chemistry.

High Resolution Crystal Structures of Mycobacterium tuberculosis Adenosine Kinase

J. Sacchettini, M. Reddy, S. Palaninathan, 2007, Journal of Biological Chemistry.

Targeting protein biotinylation enhances tuberculosis chemotherapy

J. Sacchettini, T. Ioerger, D. Schnappinger, 2018, Science Translational Medicine.

Identification of a Mycothiol-Dependent Nitroreductase from Mycobacterium tuberculosis

J. Sacchettini, T. Ioerger, J. Vendôme, 2018, ACS infectious diseases.

Metabolic bifunctionality of Rv0812 couples folate and peptidoglycan biosynthesis in Mycobacterium tuberculosis

J. Sacchettini, K. Rhee, S. Ehrt, 2021, The Journal of experimental medicine.

Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis

J. Sacchettini, T. Ioerger, D. Schnappinger, 2017, Proceedings of the National Academy of Sciences.

Peptidoglycan synthesis in Mycobacterium tuberculosis is organized into networks with varying drug susceptibility

J. Sacchettini, M. Waldor, T. Ioerger, 2015, Proceedings of the National Academy of Sciences.

Atomic structure of an αβ T cell receptor (TCR) heterodimer in complex with an anti‐TCR Fab fragment derived from a mitogenic antibody

A. Smolyar, E. Reinherz, J. Sacchettini, 1998, The EMBO journal.

Crystallization of a Deglycosylated T Cell Receptor (TCR) Complexed with an Anti-TCR Fab Fragment*

E. Reinherz, J. Sacchettini, J. Liu, 1996, The Journal of Biological Chemistry.

A Structural Difference Limited to One Residue of the Antigenic Peptide Can Profoundly Alter the Biological Outcome of the TCR-Peptide/MHC Class I Interaction1

J. Sacchettini, S. Nathenson, A. Kalergis, 2001, The Journal of Immunology.

TCR-Peptide / MHC Class I Interaction Profoundly Alter the Biological Outcome of Residue of the Antigenic Peptide Can A Structural Difference Limited to One and

J. Sacchettini, S. Nathenson, A. Kalergis, 2001 .

Mechanistic and structural studies of H373Q flavocytochrome b2: effects of mutating the active site base.

J. Sacchettini, P. Sobrado, Chi-Lin Tsai, 2007, Biochemistry.

Crystal Structure of Monoclonal 6B5 Fab Complexed with Phencyclidine*

J C Sacchettini, J. Sacchettini, D. Linthicum, 1998, The Journal of Biological Chemistry.

The crystal structure of human hypoxanthine-guanine phosphoribosyltransferase with bound GMP

James C. Sacchettini, Yiming Xu, C. Grubmeyer, 1994, Cell.

Mycobacterium tuberculosis acyl carrier protein synthase adopts two different pH-dependent structural conformations.

G. Besra, J. Sacchettini, L. Shipman, 2011, Acta crystallographica. Section D, Biological crystallography.

Second-Shell Amino Acid R266 Helps Determine N-Succinylamino Acid Racemase Reaction Specificity in Promiscuous N-Succinylamino Acid Racemase/o-Succinylbenzoate Synthase Enzymes.

M. E. Glasner, F. Raushel, J. Sacchettini, 2021, Biochemistry.

Flexibility is a likely determinant of binding specificity in the case of ileal lipid binding protein.

J. Sacchettini, H. Rüterjans, F. Zhang, 1996, Structure.

Crystal Structure and Activity Studies of the Mycobacterium tuberculosis β-Lactamase Reveal Its Critical Role in Resistance to β-Lactam Antibiotics

Feng Wang, J. Sacchettini, C. Cassidy, 2006, Antimicrobial Agents and Chemotherapy.

Mycobacterium tuberculosis SatS is a chaperone for the SecA2 protein export pathway

J. Sacchettini, M. Braunstein, N. W. Rigel, 2019, eLife.

The EXIT Strategy: an Approach for Identifying Bacterial Proteins Exported during Host Infection

J. Sacchettini, T. Ioerger, D. Oreper, 2017, mBio.

Structural insights into species-specific features of the ribosome from the human pathogen Mycobacterium tuberculosis

J. Sacchettini, J. Jakana, Jeng-Yih Chang, 2017, Nucleic acids research.

In Vitro Efficacy, Resistance Selection, and Structural Modeling Studies Implicate the Malarial Parasite Apicoplast as the Target of Azithromycin*

D. Fidock, J. Sacchettini, Qingan Sun, 2007, Journal of Biological Chemistry.

Structure and function of the virulence-associated high-temperature requirement A of Mycobacterium tuberculosis.

J. Sacchettini, W. Jacobs, M. Braunstein, 2008, Biochemistry.

A Polymorphism in the Human Intestinal Fatty Acid Binding Protein Alters Fatty Acid Transport across Caco-2 Cells (*)

C. Bogardus, J. Sacchettini, L. Baier, 1996, The Journal of Biological Chemistry.

Imaging tuberculosis with endogenous β-lactamase reporter enzyme fluorescence in live mice

James C. Sacchettini, Jeffrey D. Cirillo, Jianghong Rao, 2010, Proceedings of the National Academy of Sciences.

Structural genomics approach to drug discovery for Mycobacterium tuberculosis.

J. Sacchettini, T. Ioerger, 2009, Current opinion in microbiology.

The three-dimensional structures of a polysaccharide binding antibody to Cryptococcus neoformans and its complex with a peptide from a phage display library: implications for the identification of peptide mimotopes.

A. Casadevall, J. Sacchettini, M. Scharff, 1997, Journal of molecular biology.

The three-dimensional structure of an H-2Ld-peptide complex explains the unique interaction of Ld with beta-2 microglobulin and peptide.

J. Sacchettini, G. Balendiran, S. Nathenson, 1997, Proceedings of the National Academy of Sciences of the United States of America.

The Copper-Responsive RicR Regulon Contributes to Mycobacterium tuberculosis Virulence

J. Sacchettini, T. Ioerger, S. Butler-Wu, 2014, mBio.

A DNA-Binding Protein Tunes Septum Placement during Bacillus subtilis Sporulation

J. Sacchettini, I. Krieger, Allyssa K. Miller, 2019 .

A DNA-Binding Protein Tunes Septum Placement during Bacillus subtilis Sporulation

J. Sacchettini, I. Krieger, J. K. Herman, 2018, bioRxiv.

Mycobacterial Metabolic Syndrome: LprG and Rv1410 Regulate Triacylglyceride Levels, Growth Rate and Virulence in Mycobacterium tuberculosis

J. Sacchettini, E. Rubin, D. Moody, 2016, PLoS pathogens.

Bayesian analysis of gene essentiality based on sequencing of transposon insertion libraries

Thomas R. Ioerger, James C. Sacchettini, Michael A. DeJesus, 2013, Bioinform..

Molecular mapping of the 8.12 SLE-associated idiotype specificity at the single amino acid level.

J. Sacchettini, B. Diamond, C. Kowal, 1996, Molecular immunology.

M. tuberculosis Rv2252 encodes a diacylglycerol kinase involved in the biosynthesis of phosphatidylinositol mannosides (PIMs)

J. Sacchettini, J. Mckinney, B. Butcher, 2006, Molecular microbiology.

Discovery of Novel Nitrobenzothiazole Inhibitors for M . tuberculosis ATP Phosphoribosyl Transferase ( HisG ) through Virtual Screening

J. Sacchettini, T. Ioerger, Yoonsang Cho, 2008 .

Mycothiol biosynthesis is essential for ethionamide susceptibility in Mycobacterium tuberculosis

David Alland, James C Sacchettini, Catherine Vilchèze, 2008, Molecular microbiology.

A comparative study of the backbone dynamics of two closely related lipid binding proteins: Bovine heart fatty acid binding protein and porcine ileal lipid binding protein

C. Ludwig, J. Sacchettini, D. Fushman, 2004, Molecular and Cellular Biochemistry.

A comparative study of the backbone dynamics of two closely related lipid binding proteins: bovine heart fatty acid binding protein and porcine ileal lipid binding protein.

C. Ludwig, J. Sacchettini, D. Fushman, 1999 .

Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13

Lisa K. Woolhiser, S. Norval, J. Sacchettini, 2017, Cell.

Mycobacterium tuberculosis adenosine kinase bound to 6-methylmercaptopurine riboside

Q. Dang, J. Sacchettini, T. Parish, 2019 .

Structure-Guided Drug Design of 6-Substituted Adenosine Analogues as Potent Inhibitors of Mycobacterium tuberculosis Adenosine Kinase

Q. Dang, J. Sacchettini, T. Parish, 2019, Journal of medicinal chemistry.

The molecular basis of pyrazinamide activity on Mycobacterium tuberculosis PanD

J. Sacchettini, W. Shi, Ying Zhang, 2020, Nature Communications.

Impact of immunopathology on the antituberculous activity of pyrazinamide

J. Sacchettini, T. Ioerger, T. Dick, 2018, The Journal of experimental medicine.

Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition

J. Sacchettini, T. Ioerger, D. Schnappinger, 2019, Science.

Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase

Christopher B. Cooper, Lisa K. Woolhiser, J. Sacchettini, 2016, Antimicrobial Agents and Chemotherapy.

Genome Analysis of Multi- and Extensively-Drug-Resistant Tuberculosis from KwaZulu-Natal, South Africa

Thomas R. Ioerger, James C. Sacchettini, William R. Jacobs, 2009, PloS one.

Weighting features to recognize 3D patterns of electron density in X-ray protein crystallography

Thomas R. Ioerger, Kreshna Gopal, Tod D. Romo, 2004, Proceedings. 2004 IEEE Computational Systems Bioinformatics Conference, 2004. CSB 2004..

Recent developments in the PHENIX software for automated crystallographic structure determination.

Randy J Read, Nicholas K Sauter, Thomas C Terwilliger, 2004, Journal of synchrotron radiation.

Three-dimensional structure of Escherichia coli dihydrodipicolinate reductase.

J C Sacchettini, J. Sacchettini, G. Scapin, 1995, Biochemistry.

Refined apoprotein structure of rat intestinal fatty acid binding protein produced in Escherichia coli.

J. Gordon, J. Sacchettini, L. Banaszak, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Mycobacterium tuberculosis: a model system for structural genomics.

J. Sacchettini, Clare V. Smith, 2003, Current opinion in structural biology.

Asp79 makes a large, unfavorable contribution to the stability of RNase Sa.

Kevin L. Shaw, C. Pace, A. Makarov, 2005, Journal of molecular biology.

Guide RNA biogenesis involves a novel RNase III family endoribonuclease in Trypanosoma brucei.

S. Sze, J. Sacchettini, X. Ji, 2011, RNA.

Solution structure of ileal lipid binding protein in complex with glycocholate.

J. Sacchettini, Fengli Zhang, H. Rüterjans, 2000, European journal of biochemistry.

The Contribution of Polar Group Burial to Protein Stability Is Strongly Context-dependent*

C. Pace, J. M. Scholtz, J. Sacchettini, 2003, Journal of Biological Chemistry.

Determining Relevant Features to Recognize Electron Density Patterns in X-ray Protein Crystallography

Thomas R. Ioerger, Kreshna Gopal, Tod D. Romo, 2005, J. Bioinform. Comput. Biol..

Crystal Structure of ATP Phosphoribosyltransferase fromMycobacterium tuberculosis *

J. Sacchettini, Vivek Sharma, Yoonsang Cho, 2003, The Journal of Biological Chemistry.

Organ failure, infection, and the systemic inflammatory response syndrome are associated with elevated levels of urinary intestinal fatty acid binding protein: study of 100 consecutive patients in a surgical intensive care unit.

J. Sacchettini, W. Marks, S. Cohn, 1998, The Journal of trauma.

Reversible ligand-induced dissociation of a tryptophan-shift mutant of phosphofructokinase from Bacillus stearothermophilus.

J. Sacchettini, G. Reinhart, D. Ronning, 2002, Biochemistry.

Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-substituted triclosan derivatives.

Joel S. Freundlich, D. Fidock, J. Sacchettini, 2006, Bioorganic & medicinal chemistry letters.

Developmental and structural studies of an intracellular lipid binding protein expressed in the ileal epithelium.

J. Gordon, J. Sacchettini, S. Hauft, 1990, The Journal of biological chemistry.

Rapid point-of-care detection of the tuberculosis pathogen using a BlaC-specific fluorogenic probe.

Jianghong Rao, James C Sacchettini, Jeffrey D Cirillo, 2012, Nature chemistry.

Structure of the Mycobacterium tuberculosis d-Alanine:d-Alanine Ligase, a Target of the Antituberculosis Drug d-Cycloserine

James C. Sacchettini, J. Sacchettini, J. Bruning, 2010, Antimicrobial Agents and Chemotherapy.

Reannotation of translational start sites in the genome of Mycobacterium tuberculosis.

J. Sacchettini, T. Ioerger, M. DeJesus, 2013, Tuberculosis.

Solution structure of human intestinal fatty acid binding protein with a naturally-occurring single amino acid substitution (A54T) that is associated with altered lipid metabolism.

J. Sacchettini, Fengli Zhang, L. Baier, 2003, Biochemistry.

Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor

J. Sacchettini, E. Alvarez, J. Lavandera, 2016, EBioMedicine.

Mycolic acid cyclopropanation is essential for viability, drug resistance, and cell wall integrity of Mycobacterium tuberculosis.

M. Glickman, J. Sacchettini, Zhen Liu, 2009, Chemistry & biology.

Structure of Ribosomal Silencing Factor Bound to Mycobacterium tuberculosis Ribosome.

J. Sacchettini, L. Hung, Qingan Sun, 2015, Structure.

Structure of Ribosomal Silencing Factor Bound to Mycobacterium tuberculosis Ribosome.

Junjie Zhang, James C Sacchettini, Li-Wei Hung, 2015, Structure.

Structure of Ribosomal Sil encing Factor Bound to Mycobacterium tuberculosis Ribosome Graphical

J. Sacchettini, L. Hung, Qingan Sun, 2022 .

Activity-Based Protein Profiling Reveals That Cephalosporins Selectively Active on Non-replicating Mycobacterium tuberculosis Bind Multiple Protein Families and Spare Peptidoglycan Transpeptidases

J. Sacchettini, C. Nathan, J. Aubé, 2020, Frontiers in Microbiology.

Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III mtFabH: factors influencing catalysis and substrate specificity.

G. Besra, L. Kremer, J. Sacchettini, 2005, The Journal of biological chemistry.

Crystal structure and activity studies of the Mycobacterium tuberculosis beta-lactamase reveal its critical role in resistance to beta-lactam antibiotics.

Feng Wang, J. Sacchettini, C. Cassidy, 2006, Antimicrobial agents and chemotherapy.

The Mycobacterium tuberculosis iniA gene is essential for activity of an efflux pump that confers drug tolerance to both isoniazid and ethambutol

M. Hazbón, D. Alland, J. Sacchettini, 2005, Molecular microbiology.

Overexpression of inhA, but not kasA, confers resistance to isoniazid and ethionamide in Mycobacterium smegmatis, M. bovis BCG and M. tuberculosis

G. Besra, C. Vilchèze, L. Kremer, 2002, Molecular microbiology.

The identification of novel Mycobacterium tuberculosis DHFR inhibitors and the investigation of their binding preferences by using molecular modelling

J. Sacchettini, Wei Hong, I. Paterson, 2015, Scientific Reports.

High resolution X-ray studies of mammalian intestinal and muscle fatty acid-binding proteins provide an opportunity for defining the chemical nature of fatty acid: protein interactions

J. Gordon, J. Sacchettini, G. Scapin, 1993, Molecular and Cellular Biochemistry.

Variation among Genome Sequences of H37Rv Strains of Mycobacterium tuberculosis from Multiple Laboratories

S. Fortune, J. Sacchettini, W. Jacobs, 2010, Journal of bacteriology.

Solution structure of human intestinal fatty acid binding protein: Implications for ligand entry and exit

J. Sacchettini, Fengli Zhang, L. Baier, 1997, Journal of biomolecular NMR.

Tetraterpene Synthase Substrate and Product Specificity in the Green Microalga Botryococcus braunii Race L.

J. Sacchettini, T. Devarenne, H. Thapa, 2017, ACS chemical biology.

Ternary complex structure of human hgprtase, prpp, mg2+, and the inhibitor HPP reveals the involvement of the flexible loop in substrate binding

Yiming Xu, J. Sacchettini, G. Balendiran, 1999, Protein science : a publication of the Protein Society.

A portable brightfield and fluorescence microscope toward automated malarial parasitemia quantification in thin blood smears

J. Sacchettini, G. Coté, Paul Gordon, 2022, PloS one.

Conditional Depletion of KasA, a Key Enzyme of Mycolic Acid Biosynthesis, Leads to Mycobacterial Cell Lysis

L. Kremer, J. Sacchettini, W. Jacobs, 2005, Journal of bacteriology.

A metal-ligand-mediated intersubunit allosteric switch in related SmtB/ArsR zinc sensor proteins.

James C Sacchettini, D. Giedroc, J. Sacchettini, 2003, Journal of molecular biology.

Characterization of Phosphopantetheinyl Hydrolase from Mycobacterium tuberculosis

J. Sacchettini, C. Nathan, O. Ouerfelli, 2021, Microbiology spectrum.

The crystal structure of the orotate phosphoribosyltransferase complexed with orotate and alpha-D-5-phosphoribosyl-1-pyrophosphate.

C. Grubmeyer, J. Sacchettini, G. Scapin, 1995, Biochemistry.

Structure of the Methanococcus jannaschii Mevalonate Kinase, a Member of the GHMP Kinase Superfamily*

Dong Yang, James C Sacchettini, J. Sacchettini, 2002, The Journal of Biological Chemistry.

Identification of Compounds with Potential Antibacterial Activity against Mycobacterium through Structure-Based Drug Screening

Hiroshi Sakamoto, Mitsuru Kitamura, Koji Morita, 2013, J. Chem. Inf. Model..

R pyocin tail fiber structure reveals a receptor-binding domain with a lectin fold

J. Sacchettini, Jennifer H C Tsai, A. J. Salazar, 2019, PloS one.

Analysis of Protein-Ligand Interactions Using Localized Stereochemical Features

Thomas R. Ioerger, Reetal Pai, James C. Sacchettini, 2008, BIOCOMP.

X-ray crystallographic studies of unique cross-linked lattices between four isomeric biantennary oligosaccharides and soybean agglutinin.

J C Sacchettini, J. Sacchettini, S. Sabesan, 1997, Biochemistry.

Structure and function of Salmonella typhimurium orotate phosphoribosyltransferase: protein complementation reveals shared active sites.

C. Grubmeyer, J. Sacchettini, G. Scapin, 1995, Biochemistry.

Primary structure and crystallization of orotate phosphoribosyltransferase from Salmonella typhimurium.

C. Grubmeyer, J. Sacchettini, G. Scapin, 1993, Journal of molecular biology.

The TB structural genomics consortium: providing a structural foundation for drug discovery.

Shekhar C Mande, Tom Alber, David Eisenberg, 2002, Current drug targets. Infectious disorders.

Phosphorylation of InhA inhibits mycolic acid biosynthesis and growth of Mycobacterium tuberculosis

Gulcin Gulten, Catherine Vilchèze, C. Vilchèze, 2010, Molecular microbiology.

Three-dimensional structure of the inosine-uridine nucleoside N-ribohydrolase from Crithidia fasciculata.

V. Schramm, J. Sacchettini, M. Degano, 1996, Biochemistry.

Crystal structure and thermodynamic analysis of human brain fatty acid-binding protein.

J C Sacchettini, J. Sacchettini, G. Balendiran, 2000, The Journal of biological chemistry.

TEXTAL: AI-Based Structural Determination for X-ray Protein Crystallography

Jacob N. Smith, Thomas R. Ioerger, Kreshna Gopal, 2005, IEEE Intell. Syst..

Structure of the apo form of Bacillus stearothermophilus phosphofructokinase.

J. Sacchettini, Rockann E. Mosser, M. Reddy, 2012, Biochemistry.

Efficient retrieval of electron density patterns for modeling proteins by X-ray crystallography

Thomas R. Ioerger, Kreshna Gopal, Tod D. Romo, 2004, 2004 International Conference on Machine Learning and Applications, 2004. Proceedings..

A low-cost, novel endoscopic repeated-access port for small animal research

J. Sacchettini, Andrew B. Robbins, M. Moreno, 2020, MethodsX.

N‐Benzyl‐4‐((heteroaryl)methyl)benzamides: A New Class of Direct NADH‐Dependent 2‐trans Enoyl–Acyl Carrier Protein Reductase (InhA) Inhibitors with Antitubercular Activity

J. Sacchettini, M. Convery, Delia Blanco, 2016, ChemMedChem.

The mabA gene from the inhA operon of Mycobacterium tuberculosis encodes a 3-ketoacyl reductase that fails to confer isoniazid resistance.

J. Sacchettini, W. Jacobs, M. Sugantino, 1998, Microbiology.

Automated structure determination with phenix

Randy J. Read, Airlie J. McCoy, Laurent C. Storoni, 2006 .

J. Sacchettini, T. Ioerger, M. Braunstein, 2015, Journal of bacteriology.

Bioorganic & Medicinal Chemistry 22 (2014) 6965–6979

P. Hipskind, J. Sacchettini, T. Ioerger, 2014 .

A Lysine Acetyltransferase Contributes to the Metabolic Adaptation to Hypoxia in Mycobacterium tuberculosis.

R. Baker, J. Sacchettini, S. Shaffer, 2018, Cell chemical biology.

Structural anatomy of C1 domain interactions with DAG and other agonists

J. Sacchettini, T. Igumenova, I. Krieger, 2021, bioRxiv.

A comprehensive characterization of PncA polymorphisms that confer resistance to pyrazinamide

J. Sacchettini, T. Ioerger, E. Rubin, 2017, Nature Communications.

Structure, Activity, and Inhibition of the Carboxyltransferase β-Subunit of Acetyl Coenzyme A Carboxylase (AccD6) from Mycobacterium tuberculosis

J. Sacchettini, M. Reddy, J. Bruning, 2014, Antimicrobial Agents and Chemotherapy.

Extracting fractal features for analyzing protein structure

Thomas R. Ioerger, Yu Tao, James C. Sacchettini, 2002, Object recognition supported by user interaction for service robots.

The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites.

Joel S. Freundlich, L. Purcell, D. Fidock, 2008, Cell host & microbe.

Biochemical characterization of enoyl reductase involved in Type II fatty acid synthesis in the intestinal coccidium Eimeria tenella (Phylum Apicomplexa).

Feng Wang, J. Sacchettini, Xiangshi Tan, 2007, FEMS microbiology letters.

Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target

Robert H Bates, L. Stojanovski, K. Read, 2021, Journal of medicinal chemistry.

X-ray crystal structure of Mycobacterium tuberculosis beta-ketoacyl acyl carrier protein synthase II (mtKasB).

G. Besra, L. Kremer, J. Sacchettini, 2002, Journal of molecular biology.

KasA, another brick in the mycobacterial cell wall.

J. Sacchettini, S. Swanson, K. Gokulan, 2009, Structure.

High Throughput Screen for Escherichia coli Twin Arginine Translocation (Tat) Inhibitors

J. Sacchettini, L. Verplank, Neal Whitaker, 2016, PloS one.

Use of Multiplex Allele-Specific Polymerase Chain Reaction (MAS-PCR) to Detect Multidrug-Resistant Tuberculosis in Panama

Thomas R. Ioerger, James C. Sacchettini, J. Sacchettini, 2012, PloS one.

Development of a novel secondary phenotypic screen to identify hits within the mycobacterial protein synthesis pipeline

G. Besra, J. Sacchettini, J. Lelièvre, 2020, FASEB bioAdvances.

Automatic modeling of protein backbones in electron-density maps via prediction of Calpha coordinates.

Thomas R Ioerger, James C Sacchettini, J. Sacchettini, 2002, Acta crystallographica. Section D, Biological crystallography.

Mycobacteriophage Lysin B is a novel mycolylarabinogalactan esterase

Graham F Hatfull, J. Sacchettini, G. Hatfull, 2009, Molecular microbiology.

Novel Transthyretin Amyloid Fibril Formation Inhibitors: Synthesis, Biological Evaluation, and X-Ray Structural Analysis

Joel S. Freundlich, J. Sacchettini, A. Lapucci, 2009, PloS one.

Crystal Structure of Lyme Disease Antigen Outer Surface Protein C from Borrelia burgdorferi *

T. Klabunde, J. Sacchettini, M. Höök, 2001, The Journal of Biological Chemistry.

FINDMOL: automated identification of macromolecules in electron-density maps.

T R Ioerger, J C Sacchettini, P D Adams, 2005, Acta crystallographica. Section D, Biological crystallography.

Mycobacterium tuberculosis PptT Inhibitors Based on Heterocyclic Replacements of Amidinoureas

J. Sacchettini, C. Nathan, J. Aubé, 2023, ACS Medicinal Chemistry Letters.

Crystal Structure of Mycobacterium tuberculosis Polyketide Synthase 11 (PKS11) Reveals Intermediates in the Synthesis of Methyl-branched Alkylpyrones*

J. Sacchettini, T. Ioerger, M. Lalgondar, 2013, The Journal of Biological Chemistry.

Synthesis of Methyl-branched ( PKS 11 ) Reveals Intermediates in the Polyketide Synthase 11 tuberculosis Mycobacterium Crystal Structure of Protein Structure and Folding :

J. Sacchettini, T. Ioerger, M. Lalgondar, 2013 .

Crystal structures of the apo and ATP bound Mycobacterium tuberculosis nitrogen regulatory PII protein

J. Sacchettini, M. Reddy, J. Owen, 2010, Protein science : a publication of the Protein Society.

Crystal Structure of Hen Apo-ovotransferrin

J. Sacchettini, B. Mikami, J. Dewan, 1999, The Journal of Biological Chemistry.

Identification of cyclic hexapeptides natural products with inhibitory potency against Mycobacterium tuberculosis

A. Korkegian, J. Sacchettini, T. Ioerger, 2018, bioRxiv.

The non-clonality of drug resistance in Beijing-genotype isolates of Mycobacterium tuberculosis from the Western Cape of South Africa

J. Sacchettini, T. Ioerger, P. V. van Helden, 2010, BMC Genomics.

Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) binds triacylated glycolipid agonists of Toll-like receptor 2

J. Sacchettini, D. Moody, C. Harding, 2010, Nature Structural &Molecular Biology.

The 7-phenyl benzoxaborole series is active against Mycobacterium tuberculosis

A. Korkegian, J. Sacchettini, T. Ioerger, 2018, Tuberculosis.

Rat intestinal fatty acid binding protein. A model system for analyzing the forces that can bind fatty acids to proteins.

J. Gordon, J. Sacchettini, James C. Sacchettini, 1993, The Journal of biological chemistry.

Inhibition of InhA Activity, but Not KasA Activity, Induces Formation of a KasA-containing Complex in Mycobacteria*

C. Locht, G. Besra, C. Vilchèze, 2003, Journal of Biological Chemistry.

Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange*

J. Sacchettini, I. Krieger, Hsiao-Ling Huang, 2016, The Journal of Biological Chemistry.

High-Throughput Sequencing Enhanced Phage Display Identifies Peptides That Bind Mycobacteria

Thomas R. Ioerger, James C. Sacchettini, Alexander Pym, 2013, PloS one.

Synthesis and characterization of potent bivalent amyloidosis inhibitors that bind prior to transthyretin tetramerization.

J. Sacchettini, J. Kelly, S. Palaninathan, 2003, Journal of the American Chemical Society.

Electronic Reprint Synchrotron Radiation Recent Developments in the Phenix Software for Automated Crystallographic Structure Determination Recent Developments in the Phenix Software for Automated Crystallographic Structure Determination

R. Read, P. Adams, J. Sacchettini, 2022 .

TEXTAL: Crystallographic Protein Model Building Using AI and Pattern Recognition

Jacob N. Smith, Thomas R. Ioerger, Kreshna Gopal, 2006, AI Mag..

A Novel 6-Benzyl Ether Benzoxaborole Is Active against Mycobacterium tuberculosis In Vitro

A. Korkegian, J. Sacchettini, T. Ioerger, 2017, Antimicrobial Agents and Chemotherapy.

Whole genome sequencing identifies bacterial factors affecting transmission of multidrug-resistant tuberculosis in a high-prevalence setting

J. Sacchettini, L. Freschi, C. Contreras, 2019, Scientific Reports.

Genotypic clustering does not imply recent tuberculosis transmission in a high prevalence setting: A genomic epidemiology study in Lima, Peru

J. Sacchettini, L. Freschi, C. Contreras, 2018, bioRxiv.

The 1.25 A resolution structure of phosphoribosyl-ATP pyrophosphohydrolase from Mycobacterium tuberculosis.

J. Sacchettini, T. Ioerger, F. Javid-Majd, 2005, Acta crystallographica. Section D, Biological crystallography.

Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis

J. Sacchettini, W. Jacobs, J. Blanchard, 1995, Science.

Discovery of novel inhibitors targeting enoyl-acyl carrier protein reductase in Plasmodium falciparum by structure-based virtual screening.

Ruben Abagyan, George Nicola, James C Sacchettini, 2007, Biochemical and biophysical research communications.

Database Approaches and Data Representation in Structural Bioinformatics

Thomas R. Ioerger, Kreshna Gopal, James C. Sacchettini, 2007, 2007 IEEE 7th International Symposium on BioInformatics and BioEngineering.

Mechanisms for isoniazid action and resistance.

J C Sacchettini, J. Sacchettini, W. Jacobs, 2008, Novartis Foundation symposium.

DAIKON: A Data Acquisition, Integration, and Knowledge Capture Web Application for Target-Based Drug Discovery.

J. Sacchettini, S. Berthel, Saswati Panda, 2023, ACS pharmacology & translational science.

TEXTALTM: Artificial Intelligence Techniques for Automated Protein Structure Determination

J. Sacchettini, T. Ioerger, T. Romo, 2003, IAAI.

TEXTAL TM : Artificial Intelligence Techniques for Automated Protein Structure Determination.

Thomas R. Ioerger, Kreshna Gopal, Reetal Pai, 2003 .

Structure of N-truncated R1-type pyocin tail fiber at 1.7 angstrom resolution

J. Sacchettini, Jennifer H C Tsai, A. J. Salazar, 2019 .

Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis.

T. Blundell, J. Sacchettini, R. Payne, 2011, The Biochemical journal.

A comprehensive characterization of PncA polymorphisms that confer resistance to pyrazinamide

J. Sacchettini, T. Ioerger, E. Rubin, 2017, Nature Communications.

References and Notes Supporting Online Material Materials and Methods Figs. S1 to S5 Tables S1 to S3 Electron Impact (ei) Mass Spectra Chemical Ionization (ci) Mass Spectra References Schemas and Memory Consolidation Research Articles Research Articles Research Articles Research Articles

Dorothy Tse, Emma R Wood, Rosamund F Langston, 2022 .

Ein antibakterielles β‐Lacton bekämpft Mycobacterium tuberculosis durch Infiltration der Mykolsäurebiosynthese

T. Akopian, J. Sacchettini, S. Sieber, 2018 .

Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.

Steven M. Johnson, J. Sacchettini, K. Chiang, 2005, Journal of medicinal chemistry.

Automated structure solution with the PHENIX suite.

P. Zwart, R. Read, P. Adams, 2008, Methods in molecular biology.

A Locking Mechanism Regulates RNA Synthesis and Host Protein Interaction by the Hepatitis C Virus Polymerase*

J. Sacchettini, S. Lemon, C. Kao, 2008, Journal of Biological Chemistry.

Active Site Modifications of Organophosphorus Hydrolase for Improved Detoxification of Organophosphorus Neurotoxins

J. Sacchettini, J. Grimsley, J. Wild, 2000 .

Purification, crystallization, and preliminary X-ray data for porcine fumarase.

J. Sacchettini, L. Banaszak, S. Roderick, 1986, The Journal of biological chemistry.

Structural genomics approach to drug discovery for Mycobacterium tuberculosis.

J. Sacchettini, T. Ioerger, 2009, Current opinion in microbiology.

Recent developments in the PHENIX software for automated crystallographic structure determination.

J. Sacchettini, T. Ioerger, N. Moriarty, 2004, Journal of synchrotron radiation.

Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) binds triacylated glycolipid agonists of Toll-like receptor 2

J. Sacchettini, C. Harding, R. Rojas, 2010, Nature Structural &Molecular Biology.

Bacillus subtilis YisK possesses oxaloacetate decarboxylase activity and exhibits Mbl-dependent localization

J. Sacchettini, I. Krieger, Yitong Duan, 2023, bioRxiv.

Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase.

Joel S. Freundlich, J. Sacchettini, J. Lavandera, 2012, Chemistry & biology.

Reannotation of translational start sites in the genome of Mycobacterium tuberculosis.

J. Sacchettini, T. Ioerger, M. DeJesus, 2013, Tuberculosis.

Structural Insights into the Mechanism of the Allosteric Transitions of Mycobacterium tuberculosis cAMP Receptor Protein*

J. Sacchettini, M. Reddy, J. Bruning, 2009, The Journal of Biological Chemistry.

Guide RNA biogenesis involves a novel RNase III family endoribonuclease in Trypanosoma brucei.

S. Sze, J. Sacchettini, X. Ji, 2011, RNA.