J. Heeres

发表

Multivariate adaptive regression splines—studies of HIV reverse transcriptase inhibitors

H. M. Vinkers, D. Massart, M. Daszykowski, 2004 .

Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 variants.

H. M. Vinkers, A. D. Clark, R. Pauwels, 2004, Journal of medicinal chemistry.

Antimycotic imidazoles. part 4. Synthesis and antifungal activity of ketoconazole, a new potent orally active broad-spectrum antifungal agent.

J. Heeres, L. Backx, J. Mostmans, 1979, Journal of medicinal chemistry.

Evolution of anti-HIV drug candidates. Part 2: Diaryltriazine (DATA) analogues.

R. Pauwels, E. Arnold, F. Daeyaert, 2001, Bioorganic & medicinal chemistry letters.

TMC125, a Novel Next-Generation Nonnucleoside Reverse Transcriptase Inhibitor Active against Nonnucleoside Reverse Transcriptase Inhibitor-Resistant Human Immunodeficiency Virus Type 1

Koen Andries, Hilde Azijn, Theo Thielemans, 2004, Antimicrobial Agents and Chemotherapy.

In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, rilpivirine).

Stephen H Hughes, Peter Williams, Paul J Lewi, 2005, Journal of medicinal chemistry.

SYNOPSIS: SYNthesize and OPtimize System in Silico.

H. M. Vinkers, J. H. van Lenthe, F. Daeyaert, 2003, Journal of medicinal chemistry.

Novel diarylpyridinones, diarylpyridazinones and diarylphthalazinones as potential HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs).

Christophe M. L. Vande Velde, J. Heeres, P. Lewi, 2011, Bioorganic & medicinal chemistry.

Design and Synthesis of a Series of Piperazine‐1‐carboxamidine Derivatives with Antifungal Activity Resulting from Accumulation of Endogenous Reactive Oxygen Species

J. Heeres, L. Meerpoel, J. Pastor, 2009, ChemMedChem.

2,6-Di(arylamino)-3-fluoropyridine Derivatives as HIV Non-Nucleoside Reverse Transcriptase Inhibitors.

Christophe M. L. Vande Velde, J. Heeres, P. Lewi, 2016, Journal of medicinal chemistry.

Pareto optimal flexible alignment of molecules using a non-dominated sorting genetic algorithm

F. Daeyaert, M. D. Jonge, J. Heeres, 2005 .

The medicinal chemistry of the DATA and DAPY series of HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs)

J. Heeres, P. Lewi, 2007 .

In Vitro and In Vivo Activities of the Novel Azole Antifungal Agent R126638

J. Heeres, L. Meerpoel, J. Ausma, 2004, Antimicrobial Agents and Chemotherapy.

Rilpivirine, a Non‐Nucleoside Reverse Transcriptase Inhibitor to Treat HIV‐1

J. Heeres, P. Lewi, J. Guillemont, 2010 .

Design, synthesis, and SAR of a novel pyrazinone series with non-nucleoside HIV-1 reverse transcriptase inhibitory activity.

R. Pauwels, E. Arnold, F. Daeyaert, 2005, Journal of medicinal chemistry.

In vivo studies on the mechanism of action of the broad spectrum anticonvulsant loreclezole

J. Heeres, P. Janssen, G. Clincke, 1992, Epilepsy Research.

Antimycotic azoles. 6. Synthesis and antifungal properties of terconazole, a novel triazole ketal.

J. Heeres, J. V. van Cutsem, R. Hendrickx, 1983, Journal of medicinal chemistry.

Synthesis of novel diarylpyrimidine analogues of TMC278 and their antiviral activity against HIV-1 wild-type and mutant strains.

K. Hertogs, A. Peeters, J. Heeres, 2007, European journal of medicinal chemistry.

Evolution of anti-HIV drug candidates. Part 3: Diarylpyrimidine (DAPY) analogues.

R. Pauwels, E. Arnold, F. Daeyaert, 2001, Bioorganic & medicinal chemistry letters.

From human immunodeficiency virus non-nucleoside reverse transcriptase inhibitors to potent and selective antitrypanosomal compounds.

J. Heeres, P. Lewi, G. Vanham, 2014, Bioorganic & medicinal chemistry.

Synthesis of β‐diazosulfones

J. Heeres, J. Strating, A. M. V. Leusen, 2010 .

Development and in vitro evaluation of a vaginal microbicide gel formulation for UAMC01398, a novel diaryltriazine NNRTI against HIV-1.

Patrick Augustijns, Paul J Lewi, Jurgen Joossens, 2014, Antiviral research.

Antimycotic imidazoles. 5. Synthesis and antimycotic properties of 1-[[2-aryl-4-(arylalkyl)-1,3-dioxolan-2-yl]methyl]-1H-imidazoles.

J. Heeres, J. V. van Cutsem, 1981, Journal of medicinal chemistry.

Novel triazine dimers with potent antitrypanosomal activity.

J. Heeres, P. Lewi, L. Maes, 2018, European journal of medicinal chemistry.

Antifungal azoles for skin disorders

J. Heeres, H. Degreef, M. Borgers PhD, 2006 .

Synthesis and in vitro and in vivo Antifungal Activity of the Hydroxy Metabolites of Saperconazole

J. Heeres, M. Oris, L. Meerpoel, 2010, ChemMedChem.

Antimycotic azoles. 7. Synthesis and antifungal properties of a series of novel triazol-3-ones.

J. Heeres, L. Backx, J. V. van Cutsem, 1984, Journal of medicinal chemistry.

The preparation and antimycotic properties of derivatives of 1-phenethylimidazole.

J. Heeres, P. Janssen, J. V. van Cutsem, 1969, Journal of medicinal chemistry.

Conazoles

J. Heeres, P. Lewi, L. Meerpoel, 2010, Molecules.

ANTIMYCOTIC AZOLES. 7. SYNTHESIS AND ANTIFUNGAL PROPERTIES OF A SERIES OF NOVEL TRIAZOL-3-ONES

J. Heeres, L. Backx, J. Cutsem, 1984 .

Ketoconazole — a new broad spectrum orally active antimycotic

J. Heeres, P. Janssen, J. Cutsem, 1979, Experientia.

Structure-activity relationships in a group of azoles, with special reference to 1,3-dioxolan-2-ylmethyl derivatives

J. Heeres, 1984 .

Synthesis and screening of a new group of fungicides: 1‐(2‐phenyl‐1,3‐dioxolan‐2‐ylmethyl)‐1,2,4‐triazoles

J. Heeres, J. Gestel, M. Janssen, 1980 .

Synthesis and in vitro and in vivo structure-activity relationships of novel antifungal triazoles for dermatology.

J. Heeres, M. Oris, L. Meerpoel, 2005, Journal of medicinal chemistry.

Antimycotic imidazoles. 3. Synthesis and antimycotic properties of 1-[2-(aryloxyalkyl)-2-phenylethyl]-1H-imidazoles.

J. Heeres, L. Backx, J. Cutsem, 1977, Journal of medicinal chemistry.

Synthesis and antimyoctic properties of 1-(2-alkyl-2-phenylethyl)-1H-imidazoles.

J. Heeres, L. Backx, J. V. van Cutsem, 1976, Journal of Medicinal Chemistry.

Chapter 15 Antifungal Chemotherapy

J. Heeres, H. Bossche, 1980 .

In Vitro and In Vivo Activities of the Novel Azole Antifungal Agent R 126638

J. Heeres, L. Meerpoel, J. Ausma, 2004 .

Antimycotic imidazoles. 2. Synthesis and antimycotic properties of 1-[2-(arylalkyl)-2-phenylethyl]-1H-imidazoles.

J. Heeres, J. Mostmans, J. Cutsem, 1978, Journal of medicinal chemistry.

SYNTHESIS AND ANTIMYCOTIC PROPERTIES OF 1-(2-ALKYL-2-PHENYLETHYL)-1H-IMIDAZOLES

J. Heeres, L. Backx, J. Cutsem, 1977 .

ANTIMYCOTIC IMIDAZOLES. PART 4. SYNTHESIS AND ANTIFUNGAL ACTIVITY OF KETOCONAZOLE, A NEW POTENT ORALLY ACTIVE BROAD-SPECTRUM ANTIFUNGAL AGENT

J. Heeres, L. Backx, J. Mostmans, 1980 .

3‐(Arylamino)‐1,2,4‐triazin‐5‐one: A Novel Synthesis and Its Use

J. Heeres, P. Lewi, J. Guillemont, 2010 .

Diaryltriazine non-nucleoside reverse transcriptase inhibitors are potent candidates for pre-exposure prophylaxis in the prevention of sexual HIV transmission.

Paul J Lewi, Jurgen Joossens, Koen Augustyns, 2013, The Journal of antimicrobial chemotherapy.

Synthesis of novel diarylpyrimidine analogues and their antiviral activity against human immunodeficiency virus type 1.

K. Hertogs, R. Pauwels, E. Arnold, 2005, Journal of medicinal chemistry.

Improving QSAR models for the biological activity of HIV Reverse Transcriptase inhibitors: Aspects of outlier detection and uninformative variable elimination.

H. M. Vinkers, D. Massart, M. Daszykowski, 2005, Talanta.

A pharmacophore docking algorithm and its application to the cross‐docking of 18 HIV‐NNRTI's in their binding pockets

Frits Daeyaert, F. Daeyaert, J. Heeres, 2004, Proteins.

Classification and Regression Trees-Studies of HIV Reverse Transcriptase Inhibitors

Desire L. Massart, Beata Walczak, Paul J. Lewi, 2004, J. Chem. Inf. Model..

Structure based activity prediction of HIV-1 reverse transcriptase inhibitors.

Paul J Lewi, H. M. Vinkers, F. Daeyaert, 2005, Journal of medicinal chemistry.

Resistance and cross-resistance profile of the diaryltriazine NNRTI and candidate microbicide UAMC01398.

J. Heeres, G. Vanham, L. Heyndrickx, 2016, The Journal of antimicrobial chemotherapy.

Inhibition and substrate recognition – a computational approach applied to HIV protease

Paul J. Lewi, H. Maarten Vinkers, Marc R. de Jonge, 2003, J. Comput. Aided Mol. Des..

Correlations between Factors Determining the Pharmacokinetics and Antiviral Activity of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors of the Diaryltriazine and Diarylpyrimidine Classes of Compounds

A. D. Clark, E. Arnold, F. Daeyaert, 2004, Drugs in R&D.

On the detection of multiple-binding modes of ligands to proteins, from biological, structural, and modeling data

Eddy Arnold, Paul J. Lewi, Kalyan Das, 2003, J. Comput. Aided Mol. Des..

ANTIMYCOTIC AZOLES. 6. SYNTHESIS AND ANTIFUNGAL PROPERTIES OF TERCONAZOLE, A NOVEL TRIAZOLE KETAL

J. Heeres, J. Cutsem, R. Hendrickx, 1983 .

Synthesis, evaluation and structure-activity relationships of triazine dimers as novel antiviral agents.

J. Heeres, P. Lewi, G. Vanham, 2012, Bioorganic & medicinal chemistry letters.

Reverse transcriptase inhibitors as microbicides.

J. Heeres, P. Lewi, G. Vanham, 2012, Current HIV research.

Synthesis and in vitro and in vivo Antifungal Activity of the Hydroxy Metabolites of Saperconazole

J. Heeres, M. Oris, L. Meerpoel, 2010, ChemMedChem.