P. Janssen

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Multivariate adaptive regression splines—studies of HIV reverse transcriptase inhibitors

H. M. Vinkers, D. Massart, M. Daszykowski, 2004 .

Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 variants.

H. M. Vinkers, A. D. Clark, R. Pauwels, 2004, Journal of medicinal chemistry.

Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase. Implications for mechanisms of drug inhibition and resistance.

Jianping Ding, R. Pauwels, P. Boyer, 1994, Journal of molecular biology.

Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives

Erik De Clercq, Jan Desmyter, Dominique Schols, 1990, Nature.

Structure of HIV-1 RT/TIBO R 86183 complex reveals similarity in the binding of diverse nonnucleoside inhibitors

Henri Moereels, Koen Andries, Jianping Ding, 1995, Nature Structural Biology.

Prediction of binding affinities for TIBO inhibitors of HIV-1 reverse transcriptase using Monte Carlo simulations in a linear response method.

M L Lamb, J Tirado-Rives, W L Jorgensen, 1998, Journal of medicinal chemistry.

The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance.

A. D. Clark, Jianping Ding, P. Boyer, 2001, Journal of molecular biology.

TMC125, a Novel Next-Generation Nonnucleoside Reverse Transcriptase Inhibitor Active against Nonnucleoside Reverse Transcriptase Inhibitor-Resistant Human Immunodeficiency Virus Type 1

Koen Andries, Hilde Azijn, Theo Thielemans, 2004, Antimicrobial Agents and Chemotherapy.

In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, rilpivirine).

Stephen H Hughes, Peter Williams, Paul J Lewi, 2005, Journal of medicinal chemistry.

Receptor binding profile of R 41 468, a novel antagonist at 5-HT2 receptors.

J. Leysen, P. Janssen, P A Janssen, 1981, Life sciences.

Bridging the gap between clinical practice and diagnostic clinical epidemiology: pilot experiences with a didactic model based on a logarithmic scale.

P. Janssen, L. Lynen, A. Derese, 2007, Journal of evaluation in clinical practice.

SYNOPSIS: SYNthesize and OPtimize System in Silico.

H. M. Vinkers, J. H. van Lenthe, F. Daeyaert, 2003, Journal of medicinal chemistry.

Discriminative stimulus properties of a low dl-amphetamine dose.

C. Niemegeers, P. Janssen, F. Colpaert, 1976, Archives internationales de pharmacodynamie et de therapie.

Conformational analysis and computer graphics in drug research

P. Janssen, J. Tollenaere, P. Janssen, 1988, Medicinal research reviews.

Pharmacological and hemodynamic profile of nebivolol, a chemically novel, potent, and selective beta 1-adrenergic antagonist.

R. Reneman, P. Janssen, J. de Cree, 1988, Journal of cardiovascular pharmacology.

'Tardive' Dyskinesia: Etiological and Therapeutic Aspects

C. Niemegeers, P. Janssen, F. Awouters, 1990, Pharmacopsychiatry.

Interaction of azole derivatives with cytochrome P‐450 isozymes in yeast, fungi, plants and mammalian cells

Patrick Marichal, P. Janssen, P. Marichal, 1987 .

Mode of Action of Antifungals of Use in Immunocompromised Patients. Focus on Candida Glabrata and Histoplasma Capsulatum

P. Janssen, H. Moereels, P. Marichal, 1990 .

Biochemical Approaches to Selective Antifungal Activity. Focus on Azole Antifungals

P. Janssen, H. Moereels, P. Marichal, 1989, Mycoses.

The Molecular Basis for Itraconazole’s Activity against Aspergillus Fumigatus

H. Geerts, P. Janssen, P. Marichal, 1988 .

Mode of Action Studies: Basis for the Search of New Antifungal Drugs

H. Geerts, P. Janssen, P. Marichal, 1988, Annals of the New York Academy of Sciences.

Loperamide. Survey of studies on mechanism of its antidiarrheal activity.

A. Megens, C. Niemegeers, P. Janssen, 1993, Digestive diseases and sciences.

Evolution of anti-HIV drug candidates. Part 1: From alpha-anilinophenylacetamide (alpha-APA) to imidoyl thiourea (ITU).

R. Pauwels, E. Arnold, P. Janssen, 2001, Bioorganic & medicinal chemistry letters.

Antagonism of maximal metrazol seizures in rats and its relevance to an experimental classification of antiepileptic drugs.

C. Niemegeers, P. Lewi, P. Janssen, 1976, Arzneimittel-Forschung.

Distribution and metabolism of neuroleptic drugs. I. Pharmacokinetics of haloperidol.

P. Lewi, P. Janssen, J. Heykants, 1970, Arzneimittel-Forschung.

Bromperidol, a new butyrophenone neuroleptic: A review

C. Niemegeers, P. Janssen, B. McKenzie, 2004, Psychopharmacology.

Antitumoral effects of R 75251 on the growth of transplantable R3327 prostatic adenocarcinoma in rats

P. Janssen, L. Wouters, N. Goeminne, 1990, The Prostate.

Identification of the second extracellular loop in G-protein coupled neurotransmitter receptors as the site for ligand recognition, using spectral map analysis

P. Lewi, P. Janssen, H. Moereels, 1997 .

Distribution, metabolism and excretion of etomidate, a short-acting hypnotic drug, in the rat. Comparative study of (R)-(+)-(--)-Etomidate.

P. Lewi, P. Janssen, J. Heykants, 1975, Archives internationales de pharmacodynamie et de therapie.

CINNARIZINE (R 516), A SPECIFIC ANGIOTENSINE-BLOCKING CORONARY VASODILATOR.

P. Janssen, A. Jageneau, R. Xhonneux, 1963, Life sciences.

Ridogrel: a selective inhibitor of the cytochrome P450-dependent thromboxane synthesis.

P. Janssen, D. Bellens, H. Vanden Bossche, 1992, Biochemical pharmacology.

Receptor interactions of dopamine and serotonin antagonists: binding in vitro and in vivo and receptor regulation.

J. Leysen, P. Janssen, W. Gommeren, 1988, Psychopharmacology series.

Evidence that a preferred substrate for type b monoamine oxidase mediates stimulus properties of MAO inhibitors: A possible role for β-phenylethylamine in the cocaine cue

C. Niemegeers, P. Janssen, F. Colpaert, 1980, Pharmacology Biochemistry and Behavior.

A drug discrimination analysis of lysergic acid diethylamide (LSD): in vivo agonist and antagonist effects of purported 5-hydroxytryptamine antagonists and of pirenperone, a LSD-antagonist.

C. Niemegeers, P. Janssen, F. Colpaert, 1982, The Journal of pharmacology and experimental therapeutics.

Aromatase inhibition by R 76713: experimental and clinical pharmacology.

P. Janssen, C. Bowden, W. Amery, 1989, Journal of steroid biochemistry.

Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 1: in vivo oral pharmacology and acute toxicity. Comparison with morphine, codeine, diphenoxylate and difenoxine.

C. Niemegeers, P. Janssen, F. Lenaerts, 1974, Arzneimittel-Forschung.

On the biochemical mode of action of levamisole: an update.

P. Janssen, J. V. Van Wauwe, 1991, International journal of immunopharmacology.

Levamisole as an Adjuvant in Cancer Treatment

P. Janssen, P. Janssen, 1991, Journal of clinical pharmacology.

R 76713 and enantiomers: selective, nonsteroidal inhibitors of the cytochrome P450-dependent oestrogen synthesis.

P. Janssen, H. Moereels, D. Bellens, 1990, Biochemical pharmacology.

Characterization of receptors on postganglionic cholinergic neurons in the guinea‐pig isolated ileum

P. Janssen, B. Cox, C. Ennis, 1979, The Journal of pharmacy and pharmacology.

The head-twitch response to intraperitoneal injection of 5-hydroxytryptophan in the rat: Antagonist effects of purported 5-hydroxytryptamine antagonists and of pirenperone, an LSD antagonist

P. Janssen, F. Colpaert, 1983, Neuropharmacology.

Mutation in cytochrome P-450-dependent 14 alpha-demethylase results in decreased affinity for azole antifungals.

P. Janssen, H. Moereels, P. Marichal, 1990, Biochemical Society transactions.

R 56865 prevents electrical and mechanical signs of ouabain intoxication in guinea-pig papillary muscle.

P. Janssen, B. Vollmer, C. Meuter, 1987, European journal of pharmacology.

Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 2: in vivo parenteral pharmacology and acute toxicity in mice. Comparison with morphine, codeine and diphenoxylate.

C. Niemegeers, P. Janssen, F. Lenaerts, 1974, Arzneimittel-Forschung.

NADPH-dependent formation of 15- and 12-hydroxyeicosatrienoic acid from arachidonic acid by rat epidermal microsomes.

P. Janssen, M. Coene, W. Lauwers, 1991, Eicosanoids.

Cardiac and Hemodynamic Effects of Intravenous R80122, a New Phosphodiesterase III Inhibitor, in a Canine Model of Myocardial Ischemia and Heart Failure

R. Reneman, P. Janssen, R. Xhonneux, 1992, Journal of cardiovascular pharmacology.

Alfentanil (R 39 209) — a particularly short‐acting intravenous narcotic analgesic in rats

C. Niemegeers, P. Janssen, 1981 .

Evidence that phospholipid turnover is the signal transducing system coupled to serotonin-S2 receptor sites.

J. Leysen, P. Janssen, F. De Clerck, 1985, The Journal of biological chemistry.

Analgesics abuse: theoretical and practical considerations.

P. Janssen, F. Awouters, F. Driesens, 1993, Medical hypotheses.

Cardioprotective effects of mioflazine during 1 h normothermic global ischaemia in the canine heart.

P. Janssen, M. Borgers, P. V. Van Daele, 1984, Cardiovascular research.

Inhibition of human cardiac cyclic AMP-phosphodiesterases by R 80122, a new selective cyclic AMP-phosphodiesterase III inhibitor: a comparison with other cardiotonic compounds.

P. Janssen, E. Freyne, D. de Cheffoy de Courcelles, 1992, The Journal of pharmacology and experimental therapeutics.

Pharmacology of antidiarrheal drugs.

C. Niemegeers, P. Janssen, F. Awouters, 1983, Annual review of pharmacology and toxicology.

Cardiovascular effects of dl-nebivolol and its enantiomers--a comparison with those of atenolol.

R. Reneman, P. Janssen, A. Van de Water, 1988, European journal of pharmacology.

Hepatic reactions during ketoconazole treatment.

P. Janssen, J. Symoens, 1983, The American journal of medicine.

Identification of non-serotonergic [3H]ketanserin binding sites on human platelets and their role in serotonin release.

J. Leysen, P. Janssen, W. Gommeren, 1991, European journal of pharmacology.

Sleep improvement in dogs after oral administration of mioflazine, a nucleoside transport inhibitor

P. Janssen, A. Wauquier, H. Belle, 2004, Psychopharmacology.

The cardiovascular pharmacology of lidoflazine, a long-acting coronary vasodilator.

P. Janssen, A. Jageneau, W. Schaper, 1966, The Journal of pharmacology and experimental therapeutics.

Vascular Protection by Ketanserin, a 5-HT(2) Serotonergic Receptor Antagonist?

P. Janssen, J. Symoens, F. Clerck, 1991, Platelets.

R 68 070: Thromboxane A2 Synthetase Inhibition and Thromboxane A2/Prostaglandin Endoperoxide Receptor Blockade Combined in One Molecule - I. Biochemical Profile In Vitro

P. Janssen, F. De Clerck, F. Clerck, 1989, Thrombosis and Haemostasis.

Evidence for functional 5-HT2 receptor sites on human blood platelets.

J. Leysen, P. Janssen, F. De Clerck, 1984, Biochemical pharmacology.

Down regulation of serotonin-S2 receptor sites in rat brain by chronic treatment with the serotonin-S2 antagonists: ritanserin and setoperone

J. Leysen, P. Janssen, R. Woestenborghs, 2004, Psychopharmacology.

Evidence that pimozide is not a partial agonist of dopamine receptors.

J. Leysen, P. Janssen, J. van Nueten, 1979, Life sciences.

Bezitramide (R 4845), a new potent and orally long-acting analgesic compound.

C. Niemegeers, P. Janssen, W. Amery, 1971, Arzneimittel-Forschung.

The pharmacology of dehydrobenzperidol, a new potent and short acting neuroleptic agent chemically related to Haloperidol.

C. Niemegeers, P. Janssen, K. Schellekens, 1963, Arzneimittel-Forschung.

Inventory of the cytochrome P450 superfamily

A. Lisitsa, L. Koymans, P. Janssen, 2001 .

Cell-Based and Biochemical Analysis of the anti-HIV Activity of Combinations of 3′-azido-3′-deoxythymidine and Analogues of TIBO

P. Janssen, E. White, R. Buckheit, 1994 .

Etomidate, R-(+)-ethyl-1-( -methyl-benzyl)imidazole-5-carboxylate (R 16659), a potent, short-acting and relatively atoxic intravenous hypnotic agent in rats.

C. Niemegeers, P. Janssen, K. Schellekens, 1971, Arzneimittel-Forschung.

Nebivolol is devoid of intrinsic sympathomimetic activity.

R. Reneman, P. Janssen, A. Van de Water, 1989, European journal of pharmacology.

The Role of Cytochrome P‐450 in Dermatology

P. Janssen, H. Degreef, H. Bossche, 1989, International journal of dermatology.

Discriminative stimulus properties of benzodiazepines, barbiturates and pharmacologically related drugs; relation to some intrinsic and anticonvulsant effects.

P. Janssen, F. Colpaert, L. Desmedt, 1976, European journal of pharmacology.

Dissociation between opiate-like and antidiarrheal activities of antidiarrheal drugs.

C. Niemegeers, P. Janssen, J. Heykants, 1979, The Journal of pharmacology and experimental therapeutics.

The Pharmacology of Specific, Pure and Potent Serotonin 5-HT2 or S2-Antagonists

P. Janssen, 1982 .

S2-serotonergic receptor inhibition (ketanserin), combined with thromboxane A2/prostaglandin endoperoxide receptor blockade (BM 13.177): enhanced anti-platelet effect.

P. Janssen, F. Clerck, B. Xhonneux, 1986 .

Butyrophenones and Diphenylbutylpiperidines

P. Janssen, W. Bever, 1980 .

The antiemetic effects of domperidone, a novel potent gastrokinetic.

C. Niemegeers, P. Janssen, K. Schellekens, 1980, Archives internationales de pharmacodynamie et de therapie.

Pharmacological validation of ritanserin and risperidone in the drug discrimination test procedure in the rat

T. Meert, P. Janssen, P. Vermote, 1990 .

Synthetic analgesics. Synthesis and pharmacology of the diastereoisomers of N-(3-methyl-1-(2-phenylethyl)-4-piperidyl)-N-phenylpropanamide and N-(3-methyl-1-(1-methyl-2-phenylethyl)-4-piperidyl)-N-phenylpropanamide.

C. Niemegeers, P. Janssen, W. V. van Bever, 1974, Journal of medicinal chemistry.

Blockade of apomorphine's discriminative stimulus properties: Relation to neuroleptic activity in neuropharmacological and biochemical assays

J. Leysen, C. Niemegeers, P. Janssen, 1976, Pharmacology Biochemistry and Behavior.

R 68 070: Thromboxane A2 Synthetase Inhibition and Thromboxane A2/Prostaglandin Endoperoxide Receptor Blockade Combined in One Molecule - II. Pharmacological Effects In Vivo and Ex Vivo

P. Janssen, E. Vercammen, F. De Clerck, 1989, Thrombosis and Haemostasis.

Delay of castor oil diarrhoea in rats: a new way to evaluate inhibitors of prostaglandin biosynthesis

C. Niemegeers, P. Janssen, F. Awouters, 1978, The Journal of pharmacy and pharmacology.

Liarozole, an inhibitor of retinoic acid metabolism, exerts retinoid-mimetic effects in vivo.

P. Janssen, P. Borghgraef, M. Coene, 1992, The Journal of pharmacology and experimental therapeutics.

Biotransformation of Neuroleptanalgesics

P. Janssen, W. Soudijn, I. V. Wijngaarden, 1974, International anesthesiology clinics.

A possible α2-adrenergic component in the in vivo activity of pirenperone

P. Janssen, F. Colpaert, 1984 .

Pharmacology of the specific histamine H1-antagonist astemizole.

C. Niemegeers, P. Janssen, F. Awouters, 1983, Arzneimittel-Forschung.

Pharmacology of potent and selective S2-serotonergic antagonists.

P. Janssen, 1985, Journal of cardiovascular pharmacology.

The l-enantiomer of nebivolol potentiates the blood pressure lowering effect of the d-enantiomer.

R. Reneman, P. Janssen, R. Xhonneux, 1990, European journal of pharmacology.

Beta-adrenoceptor-mediated cAMP accumulation in cardiac cells: effects of nebivolol.

J. Leysen, P. Janssen, P. Pauwels, 1989, European journal of pharmacology.

Inhibition of 5-hydroxytryptamine-induced and-amplified human platelet aggregation by ketanserin (R 41 468), a selective 5-HT2-receptor antagonist

P. Janssen, J. David, F. Clerck, 1982, Agents and Actions.

Inhibition of 5-hydroxytryptamine-induced and-amplified human platelet aggregation by ketanserin (R 41 468), a selective 5-HT2-receptor antagonist

P. Janssen, J. David, F. Clerck, 2005, Agents and Actions.

The inhibitory effect of fentanyl and other morphine-like analgesics on the warm water induced tail withdrawl reflex in rats.

C. Niemegeers, P. Janssen, J. Dony, 1963, Arzneimittel-Forschung.

5-HT2 receptor blockade to study serotonin-induced pathology

P. Janssen, 1983 .

Pre-Incubation of Cell-Free HIV-1 Group M Isolates with Non-Nucleoside Reverse Transcriptase Inhibitors Blocks Subsequent Viral Replication in Co-Cultures of Dendritic Cells and T Cells

P. Lewi, P. Janssen, G. Vanham, 2005, Antiviral therapy.

A Series of Diaryltriazines and Diarylpyrimidines Are Highly Potent Nonnucleoside Reverse Transcriptase Inhibitors with Possible Applications as Microbicides

P. Lewi, P. Janssen, G. Vanham, 2004, Antimicrobial Agents and Chemotherapy.

The α and ω of G Protein–Coupled Receptors

L. Koymans, P. Lewi, P. Janssen, 1997 .

Structure-Activity Relationships of the Butyrophenones and Diphenylbutylpiperidines

P. Janssen, W. Bever, 1978 .

Apomorphine-antagonism in rats.

C. Niemegeers, P. Janssen, A. Jageneau, 1960, Arzneimittel-Forschung.

Is it possible to predict the clinical effects of neuroleptic drugs (major tranquillizers) from animal data? IV. An improved experimental design for measuring the inhibitory effects of neuroleptic drugs on amphetamine-or apomorphine-induced "Cheroing" and "agitation" in rats.

C. Niemegeers, P. Janssen, K. Schellekens, 1967, Arzneimittel-Forschung.

Progress in Neuropsychopharmacology: The Use of Thymosthenic Substances in Schizophrenia

P. Janssen, 1990 .

Haloperidol and Related Butyrophenones

P. Janssen, 1967 .

Sufentanil, a very potent and extremely safe intravenous morphine-like compound in mice, rats and dogs.

C. Niemegeers, P. Janssen, K. Schellekens, 1976, Arzneimittel-Forschung.

Self-administration of the analgesic suprofen in arthritic rats: evidence of Mycobacterium butyricum-induced arthritis as an experimental model of chronic pain.

C. Niemegeers, P. Janssen, F. Colpaert, 1980, Life sciences.

The effects of prior fentanyl administration and of pain on fentanyl analgesia: tolerance to and enhancement of narcotic analgesia.

C. Niemegeers, P. Janssen, F. Colpaert, 1980, The Journal of pharmacology and experimental therapeutics.

Potent, New Analgesics, Tailor‐Made for Different Purposes

P. Janssen, 1982, Acta anaesthesiologica Scandinavica.

PIRINITRAMIDE (R 3365), A POTENT ANALGESIC WITH UNUSUAL CHEMICAL STRUCTURE

P. Janssen, P. Janssen, 1961, The Journal of pharmacy and pharmacology.

Chemistry and pharmacology of CNS depressants related to 4-(4-hydroxy-phenylpiperidino)butyrophenone. I. Synthesis and screening data in mice.

C. Niemegeers, P. Janssen, K. Schellekens, 1959, Journal of medicinal and pharmaceutical chemistry.

Design, synthesis, and SAR of a novel pyrazinone series with non-nucleoside HIV-1 reverse transcriptase inhibitory activity.

R. Pauwels, E. Arnold, F. Daeyaert, 2005, Journal of medicinal chemistry.

Crystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutant.

A. D. Clark, Jianping Ding, R. Pauwels, 1996, Journal of molecular biology.

In vivo studies on the mechanism of action of the broad spectrum anticonvulsant loreclezole

J. Heeres, P. Janssen, G. Clincke, 1992, Epilepsy Research.

Novel broad-spectrum anthelmintics. Tetramisole and related derivatives of 6-arylimidazo[2,1-b]thiazole.

P. Janssen, A. Raeymaekers, J. Vandenberk, 1966, Journal of medicinal chemistry.

Tetramisole (R 8299), A New, Potent Broad Spectrum Anthelmintic

C. Niemegeers, P. Janssen, A. Raeymaekers, 1966, Nature.

1-alkyl-2-aryl-5-chloroimidazoles

P. Janssen, E. F. Godefroi, C. V. D. Eycken, 1967 .

Radioimmunoassay of the neuroleptic drug pimozide.

P. Janssen, J. Heykants, A. Knaeps, 1975, Life sciences.

Evolution of anti-HIV drug candidates. Part 1: From α-Anilinophenylacetamide (α-APA) to imidoyl thiourea (ITU)

R. Pauwels, E. Arnold, P. Janssen, 2001 .

Effect of various drugs on carrageenin‐induced oedema in the rat hind paw

C. Niemegeers, P. Janssen, F. J. Verbruggen, 1964, The Journal of pharmacy and pharmacology.

Imidazoles as hypnotic agents. II. The synthesis of certain 5,6-disubstituted 8-oxo-8H-imidazol[5,1-c][1,4]oxazines.

P. Janssen, E. F. Godefroi, Van der Eycken, 1966, The Journal of organic chemistry.

Does Ritanserin, a Potent Serotonin-S2 Antagonist, Restore Energetic Functions during the Night?

P. Janssen, P. Janssen, 1987, Journal of the Royal Society of Medicine.

Loperamide antagonism of castor oil-induced diarrhea in rats: a quantitative study.

C. Niemegeers, P. Janssen, F. Awouters, 1975, Archives internationales de pharmacodynamie et de therapie.

Interference of antimycotics and other drugs with methohexital hypnosis in rats

C. Niemegeers, P. Janssen, F. Awouters, 1989 .

In-Vitro and In-Vivo Models to Study the Activity of Antifungals against Aspergillus

P. Janssen, J. Cutsem, 1988 .

The preparation and antimycotic properties of derivatives of 1-phenethylimidazole.

J. Heeres, P. Janssen, J. V. van Cutsem, 1969, Journal of medicinal chemistry.

Inhibition and induction of microsomal enzymes in rat. A comparative study of four antimycotics: miconazole, econazole, clotrimazole and ketoconazole.

C. Niemegeers, P. Janssen, J. Levron, 1981, Archives internationales de pharmacodynamie et de therapie.

1-(1-indanyl)- and 1-(1-tetralyl)imidazole-5-carboxylate esters, a novel type of antifungal agents.

P. Janssen, J. V. van Cutsem, E. F. Godefroi, 1967, Journal of Medicinal Chemistry.

Experimental Candidosis in Animals and Chemotherapy

P. Janssen, J. Cutsem, J. Fransen, 1991 .

Effects of Inhibitors on the P450-Dependent Metabolism of Endogenous Compounds in Fungi, Protozoa, Plants and Vertebrates

P. Janssen, P. Marichal, H. Bossche, 1991 .

New Antifungal Agents: A Result of Target-Oriented Drug Design

P. Janssen, 1987 .

R 75251, a new inhibitor of steroid biosynthesis

P. Janssen, E. Snoeck, A. Raeymaekers, 1990, The Prostate.

Pharmacology of risperidone (R 64 766), a new antipsychotic with serotonin-S2 and dopamine-D2 antagonistic properties.

C J Niemegeers, A. Megens, T. Meert, 1988, The Journal of pharmacology and experimental therapeutics.

Selective inhibition of 14 alpha-desmethyl sterol synthesis in Candida albicans by terconazole, a new triazole antimycotic.

P. Janssen, A. Tobia, H. Vanden Bossche, 1988, The Journal of antimicrobial chemotherapy.

Intravenous pharmacokinetic profile in rats of etomidate, a short-acting hypnotic drug.

P. Lewi, P. Janssen, J. Heykants, 1976, Archives internationales de pharmacodynamie et de therapie.

Is there a case for P-450 inhibitors in cancer treatment?

P. Janssen, P A Janssen, J P Van Wauwe, 1989, Journal of medicinal chemistry.

Dependence of the antagonism at human platelet 5-HT2 receptors by ketanserin on the reaction pH.

P. Janssen, F. De Clerck, J. Tollenaere, 1985, Thrombosis research.

Mechanisms of action of loperamide.

P. Janssen, A. Degryse, L. Ooms, 1984, Scandinavian journal of gastroenterology. Supplement.

The activity of suprofen on nystatin-induced paw oedema in rats.

C. Niemegeers, P. Janssen, F. Awouters, 1975, Arzneimittel-Forschung.

In Vitro Evaluation of Nonnucleoside Reverse Transcriptase Inhibitors UC-781 and TMC120-R147681 as Human Immunodeficiency Virus Microbicides

Jan Balzarini, Luc Kestens, Katrien Fransen, 2004, Antimicrobial Agents and Chemotherapy.

Cytochrome-P-450-dependent metabolism of retinoic acid in rat skin microsomes: inhibition by ketoconazole.

P. Janssen, H. Vanden Bossche, G. Willemsens, 1988, Skin pharmacology : the official journal of the Skin Pharmacology Society.

From 14 alpha-demethylase inhibitors in fungal cells to androgen and oestrogen biosynthesis inhibitors in mammalian cells.

P. Janssen, P A Janssen, D. Bellens, 1990, Biochemical Society transactions.

The absolute configurations of the optical isomers of the broad spectrum anthelmintic tetramisole.

P. Janssen, A. Raeymaekers, L. F. Roevens, 1967, Tetrahedron Letters.

The biochemical mechanism of action of the antinematodal drug tetramisole.

P. Janssen, H. van den Bossche, H. V. Bossche, 1969, Biochemical pharmacology.

The biochemical mechanism of action of the anthelmintic drug tetramisole.

P. Janssen, H. van den Bossche, H. Bossche, 1967, Life sciences.

Interaction of drugs with apomorphine, tryptamine and norepinephrine. A new 'in vivo' approach: the ATN-test in rats.

C. Niemegeers, P. Janssen, F. Lenaerts, 1977, Archives internationales de pharmacodynamie et de therapie.

A critical study on RO-4-1284 antagonism in mice.

C. Niemegeers, P. Janssen, F. Colpaert, 1975, Archives internationales de pharmacodynamie et de therapie.

Studies on the regulation of sensitivity to the narcotic cue

C. Niemegeers, P. Janssen, F. Colpaert, 1978, Neuropharmacology.

Discriminative stimulus properties of fentanyl and morphine: Tolerance and dependence

C. Niemegeers, P. Janssen, F. Colpaert, 1976, Pharmacology Biochemistry and Behavior.

Nociceptive stimulation prevents development of tolerance to narcotic analgesia.

C. Niemegeers, P. Janssen, F. Colpaert, 1978, European journal of pharmacology.

Factors regulating drug cue sensitivity: limits of discriminability and the role of a progressively decreasing training dose in fentanyl-saline discrimination.

C. Niemegeers, P. Janssen, F. Colpaert, 1980, The Journal of pharmacology and experimental therapeutics.

Drug-cue conditioning to external stimulus conditions.

C. Niemegeers, P. Janssen, F. Colpaert, 1978, European journal of pharmacology.

Differential antiviral activity of two TIBO derivatives against the human immunodeficiency and murine leukemia viruses alone and in combination with other anti-HIV agents.

P. Janssen, M. Hollingshead, R. Buckheit, 1993, AIDS research and human retroviruses.

Synthesis and anti-HIV activity of 1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one (TBO) derivatives. truncated 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-ones (TIBO) analogues

Erik De Clercq, Koen Andries, Rudi Pauwels, 1999 .

A TIBO derivative, R82913, is a potent inhibitor of HIV-1 reverse transcriptase with heteropolymer templates.

R. Pauwels, P. Janssen, K. Andries, 1991, Antiviral research.

Molecular modeling studies of HIV‐1 reverse transcriptase nonnucleoside inhibitors: Total energy of complexation as a predictor of drug placement and activity

Jianping Ding, P. Boyer, S. Hughes, 1995, Protein science : a publication of the Protein Society.

The pharmacological profile of a specific, safe, effective and non-sedative anti-allergic, astemizole

C. Niemegeers, P. Janssen, F. Awouters, 1986, Agents and Actions.

Benzetimide and its optical isomers.

C. Niemegeers, P. Janssen, K. Schellekens, 1971, Arzneimittel-Forschung.

Pimozide, a chemically novel, highly potent and orally long-acting neuroleptic drug. I. The comparative pharmacology of pimozide, haloperidol, and chlorpromazine.

C. Niemegeers, P. Janssen, K. Schellekens, 1968, Arzneimittel-Forschung.

Role of Cytochrome P - 450 in the Anabolism and Catabolism of Endobiotics

P. Janssen, H. Moereels, H. Bossche, 1991 .

Synthetic antidiarrheal agents. 2,2-Diphenyl-4-(4'-aryl-4'-hydroxypiperidino)butyramides.

P. Janssen, J. Vandenberk, P. Janssen, 1973, Journal of medicinal chemistry.

Discriminative stimulus properties of cocaine: Neuropharmacological characteristics as derived from stimulus generalization experiments

C. Niemegeers, P. Janssen, F. Colpaert, 1979, Pharmacology Biochemistry and Behavior.

Discriminative stimulus properties of cocaine and d-amphetamine, and antagonism by haloperidol: A comparative study

C. Niemegeers, P. Janssen, F. Colpaert, 1978, Neuropharmacology.

Pimozide, a chemically novel, highly potent and orally long-acting neuroleptic drug. II. Kinetic study of the distribution of pimozide and metabolites in brain, liver, and blood of the Wistar rat.

P. Janssen, F. Allewijn, 1968, Arzneimittel-Forschung.

Protection of rats from compound 48/80-induced lethality. A simple test for inhibitors of mast cell-mediated shock.

C. Niemegeers, P. Janssen, F. Awouters, 1978, Archives internationales de pharmacodynamie et de therapie.

A systematic study of the pharmacological activities of dopamine antagonists.

C J Niemegeers, C. Niemegeers, P. Janssen, 1979, Life sciences.

Agonist and antagonist effects of prototype opiate drugs in rats discriminating fentanyl from saline: characteristics of partial generalization.

P. Janssen, F. Colpaert, 1984, The Journal of pharmacology and experimental therapeutics.

On the ability of narcotic antagonists to produce the narcotic cue.

C. Niemegeers, P. Janssen, F. Colpaert, 1976, The Journal of pharmacology and experimental therapeutics.

Investigations on drug produced and subjectively experienced discriminative stimuli. 2. Loperamide, an antidiarrheal devoid of narcotic cue producing actions.

C. Niemegeers, P. Janssen, F. Colpaert, 1975, Life sciences.

Investigations on drug produced and subjectively experienced discriminative stimuli. I. The fentanyl cue, a tool to investigate subjectively experience narcotic drug actions.

C. Niemegeers, P. Janssen, F. Colpaert, 1975, Life sciences.

Effects of various drugs on isolation-induced fighting behavior of male mice.

C. Niemegeers, P. Janssen, A. Jageneau, 1960, The Journal of pharmacology and experimental therapeutics.

The pharmacology of a new potent analgesic, R 951 2-[N-(4-carbethoxy-4-phenyl)-piperidino]-propiophenone HCI.

P. Janssen, A. Jageneau, D. D. de JONGH, 1958, Acta physiologica et pharmacologica Neerlandica.

Use of topical ketanserin in the treatment of skin ulcers: a double-blind study.

P. Lewi, P. Janssen, K. de Beule, 1989, Journal of the American Academy of Dermatology.

DL-1-(1-ARYLALKYL)IMIDAZOLE-5-CARBOXYLATE ESTERS. A NOVEL TYPE OF HYPNOTIC AGENTS.

C. Niemegeers, P. Janssen, P A JANSSEN, 1965, Journal of medicinal chemistry.

Etomidate, a potent non-barbiturate hypnotic. Intravenous etomidate in mice, rats, guinea-pigs, rabbits and dogs.

C. Niemegeers, P. Janssen, R. Marsboom, 1975, Archives internationales de pharmacodynamie et de therapie.

N-4-Substituted 1-(2-arylethyl)-4-piperidinyl-N-phenylpropanamides, a novel series of extremely potent analgesics with unusually high safety margin.

C. Niemegeers, P. Janssen, K. Schellekens, 1976, Arzneimittel-Forschung.

The Experimental Pharmacology of Etomidate, a New Potent, Short-Acting Intravenous Hypnotic

R. Reneman, P. Janssen, 1977 .

Antiemetic effect of haloperidol in the dog as related to plasma level and dose

C. Niemegeers, P. Janssen, J. Heykants, 2004, Psychopharmacology.

Specific α-adrenoceptor blocking effect of droperidol on isolated smooth muscles

R. Reneman, P. Janssen, J. M. Nueten, 1977 .

Identification of nonserotonergic [3H]ketanserin binding sites associated with nerve terminals in rat brain and with platelets; relation with release of biogenic amine metabolites induced by ketanserin- and tetrabenazine-like drugs.

J. Leysen, P. Janssen, W. Gommeren, 1988, The Journal of pharmacology and experimental therapeutics.

Amplification mechanisms in platelet activation and arterial thrombosis.

P. Janssen, F. De Clerck, 1990, Journal of hypertension. Supplement : official journal of the International Society of Hypertension.

SHORT-AcTING INTRAVENOUS HYPNOTIC

R. Reneman, P. Janssen, 1977 .

SPIROXAMIDE (R 5188): A NEW COMPOUND PRODUCING MORPHINE-LIKE AND CHLORPROMAZINE-LIKE EFFECTS IN ANIMALS.

C. Niemegeers, P. Janssen, J. Vannueten, 1963, International journal of neuropharmacology.

Pimozide, a chemically novel, highly potent and orally long-acting neuroleptic drug. 3. Regional distribution of pimozide and of haloperidol in the dog brain.

P. Janssen, W. Soudijn, I. van Wijngaarden, 1968, Arzneimittel-Forschung.

Concentration and pH dependent aggregation of hydrophobic drug molecules and relevance to oral bioavailability.

Paul J Lewi, Eddy Arnold, A. D. Clark, 2005, Journal of medicinal chemistry.

Ca++ and Na+ channels involved in neuronal cell death. Protection by flunarizine.

J. Leysen, P. Janssen, P. Pauwels, 1991, Life sciences.

Extracellular ions during veratridine-induced neurotoxicity in hippocampal slices: neuroprotective effects of flunarizine and tetrodotoxin

P. Janssen, R. Marrannes, D. Ashton, 1990, Brain Research.

P. Janssen, N. B. Eddy, 1960, Journal of medicinal and pharmaceutical chemistry.

The involvement of 5-HT2-receptor sites in the activation of cat platelets.

J. Leysen, P. Janssen, F. De Clerck, 1984, Thrombosis research.

Effect of serotonin antagonism in schizophrenia: A pilot study with setoperone

P. Janssen, Y. Gelders, A. Reyntjens, 2004, Psychopharmacology.

Fentanyl and apomorphine: Asymmetrical generalization of discriminative stimulus properties

C. Niemegeers, P. Janssen, F. Colpaert, 1976, Neuropharmacology.

Apomorphine as a discriminative stimulus, and its antagonism by haloperidol.

C. Niemegeers, P. Janssen, F. Colpaert, 1975, European journal of pharmacology.

Neuroleptic interference with the cocaine cue: Internal stimulus control of behavior and psychosis

C. Niemegeers, P. Janssen, F. Colpaert, 1978, Psychopharmacology.

IS IT POSSIBLE TO PREDICT THE CLINICAL EFFECTS OF NEUROLEPTIC DRUGS (MAJOR TRANQUILLIZERS) FROM ANIMAL DATA?I. "NEUROLEPTIC ACTIVITY SPECTRA" FOR RATS.

C. Niemegeers, P. Janssen, K. Schellekens, 1965, Arzneimittel-Forschung.

A characterization of LSD-antagonist effects of pirenperone in the rat

P. Janssen, F. Colpaert, 1983, Neuropharmacology.

In vivo evidence of partial agonist activity exerted by purported 5-hydroxytryptamine antagonists.

C. Niemegeers, P. Janssen, F. Colpaert, 1979, European journal of pharmacology.

Biochemical profile of risperidone, a new antipsychotic.

J. C. Stoof, J. Leysen, P. Janssen, 1988, The Journal of pharmacology and experimental therapeutics.

The peripheral and central anticholinergic properties of benzetimide (R 4929) and other atropine-like drugs as measured in a new anti-pilocarpine test in rats

C. Niemegeers, P. Janssen, 1967, Psychopharmacologia.

Does phenylethylamine act as an endogenous amphetamine in some patients?

J. Leysen, A. Megens, P. Janssen, 1999, The international journal of neuropsychopharmacology.

Cocaine cue in rats as it relates to subjective drug effects: a preliminary report.

C. Niemegeers, P. Janssen, F. Colpaert, 1976, European journal of pharmacology.

Functional interaction between serotonin-S2 and dopamine-D2 neurotransmission as revealed by selective antagonism of hyper-reactivity to tryptamine and apomorphine.

A. Megens, C. Niemegeers, P. Janssen, 1990, The Journal of pharmacology and experimental therapeutics.

Addiction and the potential for therapeutic drug development.

P. Janssen, 1994, EXS.

Narcotic cue and narcotic state: Differential involvement of brain 5-hydroxytryptamine

C. Niemegeers, P. Janssen, F. Colpaert, 1977, Neuropharmacology.

Lorcainide (R 15 889), a first review.

P. Janssen, W. Amery, J. Heykants, 1981, Acta cardiologica.

The Receptor Binding Profile of the New Antihypertensive Agent Nebivolol and its Stereoisomers Compared with Various β-Adrenergic Blockers

J. Leysen, P. Janssen, P. Pauwels, 1988, Molecular pharmacology.

Agonist and antagonist effects of prototype opiate drugs in fentanyl dose-dose discrimination

P. Janssen, F. Colpaert, 2004, Psychopharmacology.

Theoretical and methodological considerations on drug discrimination learning

C. Niemegeers, P. Janssen, F. Colpaert, 1976, Psychopharmacologia.

Non-serotonergic [3H]ketanserin binding sites in striatal membranes are associated with a dopac release system on dopaminergic nerve endings.

J. Leysen, P. Janssen, W. Gommeren, 1987, European journal of pharmacology.

Pharmacological profile of the new potent neuroleptic ocaperidone (R 79,598).

A. Megens, T. Meert, C. Niemegeers, 1992, The Journal of pharmacology and experimental therapeutics.

Ritanserin reduces abuse of alcohol, cocaine, and fentanyl in rats.

T. Meert, C. Niemegeers, P. Janssen, 1991, Pharmacopsychiatry.

Anticonvulsive properties of cinnarizine and flunarizine in rats and mice.

C. Niemegeers, P. Janssen, L. Desmedt, 1975, Arzneimittel-Forschung.

Does Endothelin‐1 Mediate Endothelium‐Dependent Contractions During Anoxia?

P. Janssen, V. Miller, K. Komori, 1989, Journal of cardiovascular pharmacology.

The evolution of the butyrophenones, haloperidol and trifluperidol, from meperidine-like 4-phenylpiperidines.

P. Janssen, P A Janssen, 1965, International review of neurobiology.

Loreclezole (R 72 063): An anticonvulsant chemically unrelated to prototype antiepileptic drugs

P. Lewi, P. Janssen, J. Vaught, 1990 .

Synthesis of novel diarylpyrimidine analogues and their antiviral activity against human immunodeficiency virus type 1.

K. Hertogs, R. Pauwels, E. Arnold, 2005, Journal of medicinal chemistry.

Discriminative stimulus properties of analgesic drugs: narcotic versus non-narcotic analgesics.

C. Niemegeers, P. Janssen, F. Colpaert, 1976, Archives internationales de pharmacodynamie et de therapie.

P. Janssen, A. Raeymaekers, A. Jageneau, 1959, Journal of medicinal and pharmaceutical chemistry.

Improving QSAR models for the biological activity of HIV Reverse Transcriptase inhibitors: Aspects of outlier detection and uninformative variable elimination.

H. M. Vinkers, D. Massart, M. Daszykowski, 2005, Talanta.

Classification and Regression Trees-Studies of HIV Reverse Transcriptase Inhibitors

Desire L. Massart, Beata Walczak, Paul J. Lewi, 2004, J. Chem. Inf. Model..

Functional role of 5-HT2 receptors in the regulation of sleep and wakefulness in the rat

J. Leysen, P. Janssen, C. Dugovic, 2004, Psychopharmacology.

Structure based activity prediction of HIV-1 reverse transcriptase inhibitors.

Paul J Lewi, H. M. Vinkers, F. Daeyaert, 2005, Journal of medicinal chemistry.

The castor oil test in rats: An in vivo method to evaluate antipropulsive and antisecretory activity of antidiarrheals?

C. Niemegeers, P. Janssen, F. Awouters, 1984 .

Narcotic cueing properties of intraventricularly administered sufentanil, fentanyl, morphine and met-enkephalin.

C. Niemegeers, P. Janssen, F. Colpaert, 1978, European journal of pharmacology.

The pharmacology of penfluridol (R 16341) a new potent and orally long-acting neuroleptic drug.

C J Niemegeers, C. Niemegeers, P. Janssen, 1970, European journal of pharmacology.

Is it possible to predict the clinical effects of neuroleptic drugs (major tranquillizers) from animal data?

C J Niemegeers, C. Niemegeers, P. Janssen, 1966, Arzneimittel-Forschung.

The pharmacology of fluspirilene (R 6218), a potent, long-acting and injectable neuroleptic drug.

C. Niemegeers, P. Janssen, K. Schellekens, 1970, Arzneimittel-Forschung.

The influence of various neuroleptic drugs on noise escape response in rats

C. Niemegeers, P. Janssen, F. J. Verbruggen, 2004, Psychopharmacologia.

Differential haloperidol effect on two indices of fentanyl-saline discrimination

C. Niemegeers, P. Janssen, F. Colpaert, 1977, Psychopharmacology.

The influence of haloperidol and amphetamine on two different noise-escape situations in rats

C. Niemegeers, P. Janssen, A. Wauquier, 2004, Psychopharmacologia.

The influence of various neuroleptic drugs on shock avoidance responding in rats

C. Niemegeers, P. Janssen, F. J. Verbruggen, 2006, Psychopharmacologia.

The influence of various neuroleptic drugs on shock avoidance responding in rats

C. Niemegeers, P. Janssen, F. J. Verbruggen, 2006, Psychopharmacologia.

The influence of various neuroleptic drugs on shock avoidance responding in rats

C. Niemegeers, P. Janssen, F. J. Verbruggen, 2004, Psychopharmacologia.

Penfluridol: a neuroleptic drug designed for long duration of action.

P. Janssen, B. H. Migdalof, J. Heykants, 1979, Drug metabolism reviews.

Differential effects of verapamil and flunarizine on epinephrine-induced vasoconstriction and on spontaneous vasomotion of arterioles in skeletal muscle in the rat in vivo.

J. Voeten, P. Janssen, F. De Clerck, 1989, Journal of cardiovascular pharmacology.

The action of neuroleptic drugs

P. Janssen, H. Haase, 1985 .

Selective interference of ACTH4–10 with discriminative responding based on the narcotic cue

C. Niemegeers, J. M. Ree, P. Janssen, 1978, Psychoneuroendocrinology.

Narcotic cuing and analgesic activity of narcotic analgesics: Associative and dissociative characteristics

C. Niemegeers, P. Janssen, F. Colpaert, 1978, Psychopharmacology.

Differential response control by isopropamide: a peripherally induced discriminative cue.

C. Niemegeers, P. Janssen, F. Colpaert, 1975, European journal of pharmacology.

Synthetic 1,4-disubstituted-1,4-dihydro-5H-tetrazol-5-one derivatives of fentanyl: alfentanil (R 39209), a potent, extremely short-acting narcotic analgesic.

P. Janssen, F. Janssens, J. Torremans, 1986, Journal of medicinal chemistry.

Serotonergic Receptors: from Ligands to Sequence

P. Janssen, H. Moereels, 1993 .

N- (4-piperidinyl) -N-phenylamides and -carbamates, processes for their preparation and pharmaceutical compositions containing these compounds

P. Janssen, G. V. Daele, 1976 .

Ca2+-mediated neuronal death in rat brain neuronal cultures by veratridine: protection by flunarizine.

J. Leysen, P. Janssen, P. Pauwels, 1989, Molecular pharmacology.

Is it possible to predict the clinical effects of neuroleptics from animal data? Part V: From haloperidol and pipamperone to risperidone.

P. Janssen, P A Janssen, F. Awouters, 1994, Arzneimittel-Forschung.

5-Hydroxytryptamine and thromboxane A2 in ischaemic heart disease.

P. Janssen, F. De Clerck, 1990, Blood Coagulation and Fibrinolysis.

Inhibition and substrate recognition – a computational approach applied to HIV protease

Paul J. Lewi, H. Maarten Vinkers, Marc R. de Jonge, 2003, J. Comput. Aided Mol. Des..

The narcotic cue: evidence for the specificity of the stimulus properties of narcotic drugs.

C. Niemegeers, P. Janssen, F. Colpaert, 1975, Archives internationales de pharmacodynamie et de therapie.

Correlations between Factors Determining the Pharmacokinetics and Antiviral Activity of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors of the Diaryltriazine and Diarylpyrimidine Classes of Compounds

A. D. Clark, E. Arnold, F. Daeyaert, 2004, Drugs in R&D.

The effect of R 58 735 (Sabeluzole) on memory functions in healthy elderly volunteers

P. Janssen, W. Amery, L. Tritsmans, 2004, Psychopharmacology.

Factors regulating drug cue sensitivity: Limits of discriminability and the role of a progressively decreasing training dose in cocaine-saline discrimination

P. Janssen, F. Colpaert, P. Janssen, 1982, Neuropharmacology.

OR discrimination: a new drug discrimination method.

P. Janssen, F. Colpaert, 1982, European journal of pharmacology.

Factors regulating drug cue sensitivity: the effects of dose ratio and absolute dose level in the case of fentanyl dose-dose discrimination.

P. Janssen, F. Colpaert, 1982, Archives internationales de pharmacodynamie et de therapie.

Mydriatic activity of analgesics in mice

P. Janssen, A. Jageneau, 1956, Experientia.

On the detection of multiple-binding modes of ligands to proteins, from biological, structural, and modeling data

Eddy Arnold, Paul J. Lewi, Kalyan Das, 2003, J. Comput. Aided Mol. Des..

The effects of suprofen in rats with implanted cotton pellets.

C. Niemegeers, P. Janssen, F. Awouters, 1975, Arzneimittel-Forschung.

P. Janssen, A. Raeymaekers, A. Jageneau, 1960, Journal of medicinal and pharmaceutical chemistry.

The relationship between chemical structure and CNS-depressant activity of basic ketones related to haloperidol

P. Janssen, 1962 .

The influence of haloperidol and chemically related neuroleptics on free amino acid content of rat brain

P. Janssen, H. Soep, 1961 .

Unusual mechanism of hypotensive activity exerted by erytrho-1-(1-[2-(1,4-benzodioxan-2-yl)-2-OH-ET-a1-4-piperidyl)-2-benzimidazolinone (R 28935).

R. Reneman, P. Janssen, P. van Bogaert, 1975, Archives internationales de pharmacodynamie et de therapie.

Regional distribution of halopemide, a new psychotropic agent, in the rat brain at different time intervals and after chronic administration.

P. Janssen, W. Soudijn, A. Loonen, 1979, Life sciences.

Regional localization of halopemide, a new psychotropic agent, in the rat brain.

P. Janssen, W. Soudijn, A. Loonen, 1978, European journal of pharmacology.

INFLUENCE OF HALOPERIDOL (R 1625) AND OF HALOPERIDIDE (R 3201) ON AVOIDANCE AND ESCAPE BEHAVIOUR OF TRAINED DOGS IN A “JUMPING BOX”

C. Niemegeers, P. Janssen, 1960, The Journal of pharmacy and pharmacology.

Synthetic antidiarrhoeal agents--I. Some pharmacological properties of R 1132 and related compounds.

P. Janssen, A. Jageneau, J. Huygens, 1959, Journal of medicinal and pharmaceutical chemistry.

Classification and discrimination for data analysis in pharmacology.

P. Lewi, P. Janssen, W. V. van Bever, 1976, European journal of pharmacology.

[Serotonin antagonism involved in the antipsychotic effect. Confirmation with ritanserine and risperidone].

C. Niemegeers, P. Janssen, F. Awouters, 1990, L'Encephale.

Chemistry and pharmacology of compounds related to 4-(4-hydroxy-4-phenyl-piperidino)-butyrophenone

P. Janssen, K. Schellekens, A. Jageneau, 1959, Psychopharmacologia.

Chemistry and pharmacology of compounds related to 4-(4-hydroxy-4-phenyl-piperidino)-butyrophenone. III. Duration of antiemetic action and oral effectiveness of Haloperidol (R 1625) and of chlorpromazine in dogs.

C. Niemegeers, P. Janssen, K. Schellekens, 1960, Arzneimittel-Forschung.

On the distribution and metabolism of neuroleptic drugs. 3. Pharmacokinetics of trifluperidol.

P. Lewi, P. Janssen, J. Heykants, 1970, Arzneimittel-Forschung.

Difenoxine (R 15403), the active metabolite of diphenoxylate (R 1132). 2. Difneozine, a potent, orally active and safe antidiarrheal agent in rats.

C. Niemegeers, P. Janssen, F. Lenaerts, 1972, Arzneimittel-Forschung.

Structure and mechanism of action of nonnucleoside inhibitors of HIV-1 reverse transcriptase: strategies to combat drug resistance

S. Hughes, E. Arnold, P. Janssen, 1998 .

Suprofen, a potent antagonist of ultraviolet-erythema in guinea-pigs.

P. Janssen, F. Awouters, Carlos J. E. Niemegeers, 1975, Arzneimittel-Forschung.

The action of neuroleptic drugs : a psychiatric, neurologic and pharmacological investigation

P. Janssen, H. Haase, 1965 .