J. Chou

发表

Uses of Next-Generation Sequencing Technologies for the Diagnosis of Primary Immunodeficiencies

Michael Seleman, R. Hoyos-Bachiloglu, R. Geha, 2017, Front. Immunol..

Recurrent viral infections associated with a homozygous CORO1A mutation that disrupts oligomerization and cytoskeletal association.

Toshiro K. Ohsumi, R. Geha, J. Chou, 2016, The Journal of allergy and clinical immunology.

Broad spectrum of autoantibodies in patients with Wiskott-Aldrich syndrome and X-linked thrombocytopenia.

L. Notarangelo, R. Geha, J. Chou, 2015, The Journal of allergy and clinical immunology.

NOD2-associated diseases: Bridging innate immunity and autoinflammation.

J. Chou, F. Bonilla, F. Dedeoglu, 2010, Clinical immunology.

A digenic human immunodeficiency characterized by IFNAR1 and IFNGR2 mutations

R. Hoyos-Bachiloglu, R. Geha, J. Chou, 2017, The Journal of clinical investigation.

Predictors of clinical success in a multidisciplinary model of atopic dermatitis treatment.

J. Chou, L. Schneider, Jennifer S LeBovidge, 2011, Allergy and asthma proceedings.

A young girl with severe cerebral fungal infection due to card 9 deficiency.

J. Chou, T. Chatila, I. Tezcan, 2018, Clinical immunology.

Phenotype, penetrance, and treatment of 133 cytotoxic T‐lymphocyte antigen 4–insufficient subjects

O. Elemento, T. Giese, A. Schulz, 2018, The Journal of allergy and clinical immunology.

Presence of hypogammaglobulinemia and abnormal antibody responses in GATA2 deficiency.

L. Notarangelo, R. Geha, J. Chou, 2014, The Journal of allergy and clinical immunology.

Defective actin accumulation impairs human natural killer cell function in patients with dedicator of cytokinesis 8 deficiency.

J. Orange, R. Geha, J. Chou, 2013, The Journal of allergy and clinical immunology.

Genetic diagnosis of immune dysregulation can lead to targeted therapy for interstitial lung disease: A case series and single center approach

J. Chou, L. Henderson, J. Whangbo, 2022, Pediatric pulmonology.

A homozygous mucosa-associated lymphoid tissue 1 (MALT1) mutation in a family with combined immunodeficiency.

Toshiro K. Ohsumi, R. Geha, J. Chou, 2013, The Journal of allergy and clinical immunology.

A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity

D. Chaussabel, J. Casanova, P. Li, 2018, Science Immunology.

A novel truncating mutation in MYD88 in a patient with BCG adenitis, neutropenia and delayed umbilical cord separation.

Michael Seleman, R. Geha, J. Chou, 2019, Clinical immunology.

Hematopoietic Stem Cell Transplantation Outcomes for 11 Patients with Dedicator of Cytokinesis 8 (DOCK8) Deficiency

L. Notarangelo, J. Chou, W. Al-Herz, 2017 .

Autoimmune lymphoproliferative syndrome caused by a homozygous FasL mutation that disrupts FasL assembly.

L. Notarangelo, R. Geha, J. Chou, 2016, The Journal of allergy and clinical immunology.

Hematopoietic stem cell transplantation outcomes for 11 patients with dedicator of cytokinesis 8 deficiency.

Douglas R. McDonald, L. Notarangelo, R. Geha, 2016, The Journal of allergy and clinical immunology.

A novel mutation in ORAI1 presenting with combined immunodeficiency and residual T-cell function.

Toshiro K. Ohsumi, R. Geha, J. Chou, 2015, The Journal of allergy and clinical immunology.

Multisystem Inflammation and Susceptibility to Viral infections in Human ZNFX1 Deficiency.

H. Omran, R. Geha, J. Chou, 2021, The Journal of allergy and clinical immunology.

Genotype and functional correlates of disease phenotype in deficiency of adenosine deaminase 2 (DADA2).

R. Geha, J. Chou, G. Lefranc, 2020, The Journal of allergy and clinical immunology.

Combined immunodeficiency due to a mutation in the γ1 subunit of the coat protein I complex.

J. Orange, R. Geha, J. Chou, 2021, The Journal of clinical investigation.

Exaggerated follicular helper T‐cell responses in patients with LRBA deficiency caused by failure of CTLA4‐mediated regulation

R. Geha, J. Chou, T. Chatila, 2017, The Journal of allergy and clinical immunology.

A novel mutation in NCF2 associated with autoimmune disease and a solitary late-onset infection.

R. Geha, J. Chou, W. Al-Herz, 2015, Clinical immunology.

Hematopoietic stem cell transplantation is a curative therapy for transferrin receptor 1 (TFRC) deficiency.

R. Geha, J. Chou, W. Al-Herz, 2020, The journal of allergy and clinical immunology. In practice.

A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency

Toshiro K. Ohsumi, N. Andrews, M. Fleming, 2015, Nature Genetics.

Atypical phenotype of an old disease or typical phenotype of a new disease: deficiency of adenosine deaminase 2.

R. Geha, J. Chou, M. Çakan, 2019, The Turkish journal of pediatrics.

Mutations in pyrin masquerading as a primary immunodeficiency.

R. Geha, J. Chou, M. Massaad, 2016, Clinical immunology.

Advances in basic and clinical immunology in 2016

R. Geha, J. Chou, J. Chinen, 2017, The Journal of allergy and clinical immunology.

The LRRC8A Mediated “Swell Activated” Chloride Conductance Is Dispensable for Vacuolar Homeostasis in Neutrophils

R. Geha, J. Chou, A. Segal, 2017, Front. Pharmacol..

Human primary immunodeficiency caused by expression of a kinase-dead p110δ mutant.

Jared L. Johnson, L. Cantley, R. Geha, 2019, The Journal of allergy and clinical immunology.

Characterization of the clinical and immunological phenotype and management of 157 individuals with 56 distinct heterozygous NFKB1 mutations.

William J. Astle, Sri V. V. Deevi, Kenneth G. C. Smith, 2020, The Journal of allergy and clinical immunology.

Immunologic reconstitution following hematopoietic stem cell transplantation despite lymph node paucity in NF-κB-inducing kinase deficiency.

K. Schwarz, A. Schulz, R. Geha, 2018, The Journal of allergy and clinical immunology.

14 Years after Discovery: Clinical Follow-up on 15 Patients with Inducible Co-Stimulator Deficiency

R. Geha, J. Chou, T. Morio, 2017, Front. Immunol..

Thymopoiesis, Alterations in Dendritic Cells and Tregs, and Reduced T Cell Activation in Successful Extracorporeal Photopheresis Treatment of GVHD

J. Chou, A. Gennery, A. Flinn, 2021, Journal of Clinical Immunology.

Long‐term outcomes of 176 patients with X‐linked hyper‐IgM syndrome treated with or without hematopoietic cell transplantation

L. Notarangelo, J. Chou, C. Cunningham-Rundles, 2017, The Journal of allergy and clinical immunology.

Leucine‐rich repeat containing 8A (LRRC8A)–dependent volume‐regulated anion channel activity is dispensable for T‐cell development and function

D. Clapham, R. Geha, J. Chou, 2017, The Journal of allergy and clinical immunology.

LRRC8 family proteins within lysosomes regulate cellular osmoregulation and enhance cell survival to multiple physiological stresses

R. Geha, J. Chou, T. Cover, 2020, Proceedings of the National Academy of Sciences.

Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C

A. Randolph, J. Chou, C. Lange, 2022, Nature Communications.

A novel homozygous mutation in Recombination Activating Gene 2 in two relatives with different clinical phenotypes: Omenn syndrome and Hyper-IgM syndrome

L. Notarangelo, Yu Nee Lee, R. Geha, 2012 .

The Notch1/CD22 signaling axis disrupts Treg function in SARS-CoV-2–associated multisystem inflammatory syndrome in children

A. Randolph, R. Geha, J. Chou, 2022, The Journal of clinical investigation.

The resurgence of a neglected orthopoxvirus: Immunologic and clinical aspects of monkeypox virus infections over the past six decades

J. Chou, Amer Al-Musa, Brenna LaBere, 2022, Clinical immunology.

Cernunnos deficiency associated with BCG adenitis and autoimmunity: First case from the national Iranian registry and review of the literature.

R. Geha, J. Chou, A. Aghamohammadi, 2017, Clinical immunology.

NFKB2 haploinsufficiency identified via screening for IFN-α2 autoantibodies in children and adolescents hospitalized with SARS-CoV-2–related complications

J. Derisi, A. Randolph, R. Geha, 2022, Journal of Allergy and Clinical Immunology.

A novel mutation in the JH4 domain of JAK3 causing severe combined immunodeficiency complicated by vertebral osteomyelitis.

Michael Seleman, R. Geha, J. Chou, 2017, Clinical immunology.

Accumulation of Tissue Factor into Developing Thrombi In Vivo Is Dependent upon Microparticle P-Selectin Glycoprotein Ligand 1 and Platelet P-Selectin

J. Chou, B. Furie, K. Croce, 2003, The Journal of experimental medicine.

Spectrum of Phenotypes Associated with Mutations in LRBA

R. Geha, J. Chou, M. Massaad, 2015, Journal of Clinical Immunology.

Genetic Predisposition to Neurological Complications in Patients with COVID-19

A. Hoischen, M. Zody, A. Randolph, 2023, Biomolecules.

Use of whole exome and genome sequencing in the identification of genetic causes of primary immunodeficiencies

Toshiro K. Ohsumi, R. Geha, J. Chou, 2012, Current opinion in allergy and clinical immunology.

Comprehensive Genetic Results for Primary Immunodeficiency Disorders in a Highly Consanguineous Population

L. Notarangelo, R. Geha, J. Chou, 2019, Front. Immunol..

Use of Genetic Testing for Primary Immunodeficiency Patients

J. Orange, J. Chou, T. Torgerson, 2018, Journal of Clinical Immunology.

Expanding the Nude SCID/CID Phenotype Associated with FOXN1 Homozygous, Compound Heterozygous, or Heterozygous Mutations

F. Benfenati, A. E. Sousa, G. Giardino, 2021, Journal of Clinical Immunology.

A novel disease-causing CD40L mutation reduces expression of CD40 ligand, but preserves CD40 binding capacity.

R. Geha, J. Chou, M. Massaad, 2014, Clinical immunology.

Chronic mucocutaneous candidiasis associated with an SH2 domain gain-of-function mutation that enhances STAT1 phosphorylation.

R. Geha, J. Chou, M. Massaad, 2016, The Journal of allergy and clinical immunology.

Transferrin receptor 1 is a cellular receptor for human heme-albumin

R. Geha, J. Chou, H. Stockinger, 2020, Communications Biology.

Dysregulated actin dynamics in activated PI3Kδ syndrome.

R. Geha, J. Chou, Craig D. Platt, 2019, Clinical Immunology.

Novel biallelic TRNT1 mutations resulting in sideroblastic anemia, combined B and T cell defects, hypogammaglobulinemia, recurrent infections, hypertrophic cardiomyopathy and developmental delay.

V. Lougaris, A. Plebani, R. Badolato, 2017, Clinical immunology.

Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections.

Toshiro K. Ohsumi, D. Goldstein, M. Knip, 2015, The New England journal of medicine.

Clinical, immunologic, and genetic spectrum of 696 patients with combined immunodeficiency

M. Afarideh, A. Ghajar, R. Geha, 2017, The Journal of allergy and clinical immunology.

Combined immunodeficiency due to a homozygous mutation in ORAI1 that deletes the C-terminus that interacts with STIM 1.

R. Geha, J. Chou, M. Massaad, 2016, Clinical immunology.

Immunology of SARS-CoV-2 infection in children

A. Randolph, J. Chou, P. Thomas, 2022, Nature Immunology.

The interferon landscape along the respiratory tract impacts the severity of COVID-19

R. Spreafico, J. Chou, F. Meloni, 2021, Cell.

Gene hunting in the genomic era: approaches to diagnostic dilemmas in patients with primary immunodeficiencies.

R. Geha, J. Chou, Craig D. Platt, 2014, The Journal of allergy and clinical immunology.

Hematopoietic cell-derived microparticle tissue factor contributes to fibrin formation during thrombus propagation.

Nigel Mackman, J. Chou, N. Mackman, 2004, Blood.

Diagnostic Interpretation of Genetic Studies in Patients with Primary Immunodeficiency Diseases: A Working Group Report of the Primary Immunodeficiency Diseases Committee of the American Academy of Allergy, Asthma, and Immunology.

Ivan K. Chinn, J. Orange, J. Walter, 2019, The Journal of allergy and clinical immunology.

Immune dysregulation and multisystem inflammatory syndrome in children (MIS-C) in individuals with haploinsufficiency of SOCS1

Douglas R. McDonald, A. Randolph, R. Geha, 2020, Journal of Allergy and Clinical Immunology.

The physical form of microbial ligands bypasses the need for dendritic cell migration to stimulate adaptive immunity

R. Spreafico, J. Chou, Y. Iwakura, 2020, bioRxiv.

Combined immunodeficiency with autoimmunity caused by a homozygous missense mutation in inhibitor of nuclear factor 𝛋B kinase alpha (IKKα)

V. Lougaris, A. Plebani, R. Hoyos-Bachiloglu, 2021, Science Immunology.

Combined immunodeficiency in a patient with c-Rel deficiency.

R. Geha, J. Chou, W. Al-Herz, 2019, The Journal of allergy and clinical immunology.

Human RELA haploinsufficiency results in autosomal-dominant chronic mucocutaneous ulceration

Toshiro K. Ohsumi, R. Geha, J. Chou, 2017, The Journal of experimental medicine.

Natural Killer Cells from Patients with Recombinase-Activating Gene and Non-Homologous End Joining Gene Defects Comprise a Higher Frequency of CD56bright NKG2A+++ Cells, and Yet Display Increased Degranulation and Higher Perforin Content

L. Notarangelo, J. Walter, V. Lougaris, 2017, Front. Immunol..

Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function

R. Geha, J. Chou, J. Manis, 2014, The Journal of experimental medicine.

Leukocyte‐versus microparticle‐mediated tissue factor transfer during arteriolar thrombus development

J. Chou, B. Furie, B. Furie, 2005, Journal of leukocyte biology.

Deficient LRRC8A-dependent volume-regulated anion channel activity is associated with male infertility in mice.

J. Jaubert, R. Geha, J. Chou, 2018, JCI insight.

Efficacy and economics of targeted panel versus whole exome sequencing in 878 patients with suspected primary immunodeficiency.

R. Geha, J. Chou, Wayne Bainter, 2020, The Journal of allergy and clinical immunology.

A novel variant in STAT2 presenting with hemophagocytic lymphohistiocytosis.

R. Geha, J. Chou, L. Bartnikas, 2019, The Journal of allergy and clinical immunology.

Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency.

J. B. Oliveira, R. Gelman, L. Notarangelo, 2015, The Journal of clinical investigation.

A novel homozygous mutation in recombination activating gene 2 in 2 relatives with different clinical phenotypes: Omenn syndrome and hyper-IgM syndrome.

L. Notarangelo, R. Geha, J. Chou, 2012, The Journal of allergy and clinical immunology.

Advances in clinical outcomes: What we have learned during the COVID-19 pandemic

J. Chou, S. Habiballah, A. Nguyen, 2021, Journal of Allergy and Clinical Immunology.

A Case of STK4 Deficiency with Complications Evoking Mycobacterial Infection

J. Chou, S. Reda, N. Radwan, 2020, Journal of Clinical Immunology.

Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency.

J. B. Oliveira, R. Gelman, L. Notarangelo, 2016, The Journal of clinical investigation.

Spectrum of Phenotypes Associated with Mutations in LRBA

R. Geha, J. Chou, M. Massaad, 2015, Journal of Clinical Immunology.

Transferrin receptor 1 is a cellular receptor for human heme-albumin

R. Geha, J. Chou, H. Stockinger, 2020, Communications Biology.

Immunodeficiency and EBV-induced lymphoproliferation caused by 4-1BB deficiency.

A. Schulz, R. Geha, J. Chou, 2019, The Journal of allergy and clinical immunology.

F-BAR domain only protein 1 (FCHO1) deficiency is a novel cause of combined immune deficiency in human subjects.

L. Notarangelo, R. Geha, J. Chou, 2019, The Journal of allergy and clinical immunology.

Immunodeficiency and Epstein Barr virus induced lymphoproliferation caused by 4-1BB deficiency

Faisal, A. Schulz, R. Geha, 2019 .

Phenotypical heterogeneity in RAG‐deficient patients from a highly consanguineous population

M. van der Burg, R. Geha, J. Chou, 2018, Clinical and Experimental Immunology.

Lessons in gene hunting: a RAG1 mutation presenting with agammaglobulinemia and absence of B cells.

Toshiro K. Ohsumi, J. Orange, L. Notarangelo, 2014, The Journal of allergy and clinical immunology.

Clinical, immunological, molecular and therapeutic findings in monogenic immune dysregulation diseases: Middle East and North Africa registry.

R. Geha, J. Chou, W. Al-Herz, 2022, Clinical immunology.

Mechanisms underlying genetic susceptibility to multisystem inflammatory syndrome in children (MIS-C)

David A. Williams, A. Randolph, R. Geha, 2021, Journal of Allergy and Clinical Immunology.

Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity.

Toshiro K. Ohsumi, L. Notarangelo, R. Geha, 2016, The Journal of clinical investigation.

DNA recombination defects in Kuwait: Clinical, immunologic and genetic profile

L. Notarangelo, R. Geha, J. Chou, 2017, Clinical Immunology.

Hypomorphic variants in AK2 reveal the contribution of mitochondrial function to B cell activation.

R. Hoyos-Bachiloglu, R. Geha, J. Chou, 2019, The Journal of allergy and clinical immunology.

A monoallelic activating mutation in RAC2 resulting in a combined immunodeficiency.

V. Lougaris, A. Plebani, Michael Seleman, 2019, The Journal of allergy and clinical immunology.

Detection of Sp110 by Flow Cytometry and Application to Screening Patients for Veno-occlusive Disease with Immunodeficiency

L. Notarangelo, R. Geha, J. Chou, 2017, Journal of Clinical Immunology.

Regulatory T-cell deficiency and immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like disorder caused by loss-of-function mutations in LRBA.

Toshiro K. Ohsumi, R. Geha, J. Chou, 2015, The Journal of allergy and clinical immunology.

Combined immunodeficiency in a patient with deficiency of c-Rel

R. Geha, J. Chou, W. Al-Herz, 2019 .

A novel mutation in ICOS presenting as hypogammaglobulinemia with susceptibility to opportunistic pathogens.

R. Geha, J. Chou, W. Al-Herz, 2015, The Journal of allergy and clinical immunology.

Autoimmunity and immunodeficiency.

R. Hoyos-Bachiloglu, J. Chou, 2020, Current opinion in rheumatology.

Combined immunodeficiency with EBV positive B cell lymphoma and epidermodysplasia verruciformis due to a novel homozygous mutation in RASGRP1.

R. Hoyos-Bachiloglu, R. Geha, J. Chou, 2017, Clinical immunology.

Activation of the small GTPases, rac and cdc42, after ligation of the platelet PAR-1 receptor.

J. Hartwig, J. Chou, A. Azim, 2000, Blood.

DOCK8 Deficiency Presenting as an IPEX-Like Disorder

R. Geha, J. Chou, T. Chatila, 2017, Journal of Clinical Immunology.

PAR-1 receptor Activation of the small GTPases, rac and cdc42, after ligation of the platelet

J. Hartwig, J. Chou, A. Azim, 2013 .

Distinct clinical and immunological features of SARS-COV-2-induced multisystem inflammatory syndrome in children.

J. Chou, L. Henderson, J. Newburger, 2020, The Journal of clinical investigation.

T-cell mitochondrial dysfunction and lymphopenia in DOCK2-deficient patients.

R. Geha, J. Chou, S. Pai, 2019, The Journal of allergy and clinical immunology.

Author Correction: Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C

A. Randolph, J. Chou, C. Lange, 2022, Nature Communications.

Measurement of SARS-CoV-2 antigens in plasma of pediatric patients with acute COVID-19 or MIS-C using an ultrasensitive and quantitative immunoassay.

A. Randolph, J. Chou, S. Schwartz, 2022, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Immunoglobulins in the treatment of COVID-19 infection: Proceed with caution!☆

Douglas R. McDonald, R. Geha, J. Chou, 2020, Clinical Immunology.

Immune dysregulation caused by homozygous mutations in CBLB

R. Geha, J. Chou, N. Ameziane, 2022, The Journal of clinical investigation.

Filamin A, the Arp2/3 complex, and the morphology and function of cortical actin filaments in human melanoma cells

J. Hartwig, T. Stossel, J. Chou, 2001, The Journal of cell biology.

ITK deficiency presenting as Autoimmune Lymphoproliferative Syndrome.

G. Pinkus, R. Geha, J. Chou, 2020, The Journal of allergy and clinical immunology.

Optical genome mapping identifies rare structural variations as predisposition factors associated with severe COVID-19

A. Hoischen, V. Bafna, M. Zody, 2022, iScience.

Epidermodysplasia verruciformis as a manifestation of ARTEMIS deficiency in a young adult.

R. Geha, J. Chou, M. Massaad, 2017, The Journal of allergy and clinical immunology.

Rethinking newborn screening for severe combined immunodeficiency: Lessons from an international partnership for patients with primary immunodeficiencies in Pakistan.

R. Geha, J. Chou, M. Massaad, 2019, Clinical immunology.

DOCK8 Deficiency Presenting as an IPEX-Like Disorder

R. Geha, J. Chou, T. Chatila, 2017, Journal of Clinical Immunology.

Severe combined immunodeficiency caused by Inositol-trisphosphate 3-Kinase B (ITPKB) deficiency.

R. Geha, J. Chou, Jennifer Jones, 2020, The Journal of allergy and clinical immunology.

A novel mutation in FOXN1 resulting in SCID: a case report and literature review.

R. Geha, J. Chou, M. Massaad, 2014, Clinical immunology.

Corrigendum: Natural Killer Cells from Patients with Recombinase-Activating Gene and Non-Homologous End Joining Gene Defects Comprise a Higher Frequency of CD56bright NKG2A+++ Cells, and Yet Display Increased Degranulation and Higher Perforin Content

L. Notarangelo, J. Walter, V. Lougaris, 2017, Front. Immunol..

Regulatory T Cell Deficiency and Immune dysregulation, Polyendocrinopathy, Enteropathy, X-Linked-Like Disorder Due to Loss of Function Mutations in LRBA

R. Geha, J. Chou, M. Massaad, 2015 .

Detection of Sp110 by Flow Cytometry and Application to Screening Patients for Veno-occlusive Disease with Immunodeficiency

L. Notarangelo, R. Geha, J. Chou, 2017, Journal of Clinical Immunology.

Acetaminophen inhibits the neutrophil oxidative burst: implications for diagnostic testing.

R. Geha, J. Chou, C. Yee, 2020, The journal of allergy and clinical immunology. In practice.

A homozygous mucosa-associated lymphoid tissue 1 (MALT1) mutation in a family with combined immunodeficiency.

Toshiro K. Ohsumi, R. Geha, J. Chou, 2013, The Journal of allergy and clinical immunology.

Deficient LRRC8A-dependent volume-regulated anion channel activity is associated with male infertility in mice.

J. Jaubert, R. Geha, J. Chou, 2018, JCI insight.

Use of Genetic Testing for Primary Immunodeficiency Patients

J. Orange, J. Chou, T. Torgerson, 2018, Journal of Clinical Immunology.

Rethinking immunologic risk: a retrospective cohort study of severe SARS-CoV-2 infections in individuals with congenital immunodeficiencies.

Douglas R. McDonald, J. Chou, Shira Rockowitz, 2023, The journal of allergy and clinical immunology. In practice.

Measurement of SARS-CoV-2 antigens in plasma of pediatric patients with acute COVID-19 or MIS-C using an ultrasensitive and quantitative immunoassay

A. Randolph, J. Chou, S. Schwartz, 2021, medRxiv.