S. Tangye

发表

The 2017 IUIS Phenotypic Classification for Primary Immunodeficiencies

J. Casanova, J. Franco, A. Bousfiha, 2017, Journal of Clinical Immunology.

B cell–intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans

Sami Al-Hajjar, J. Casanova, S. Choo, 2010, The Journal of experimental medicine.

Impaired Epstein-Barr virus-specific CD8+ T-cell function in X-linked lymphoproliferative disease is restricted to SLAM family-positive B-cell targets.

S. Tangye, P. Rohrlich, A. Rickinson, 2010, Blood.

Genetic susceptibility to EBV infection: insights from inborn errors of immunity

S. Tangye, 2020, Human Genetics.

Human RHOH deficiency causes T cell defects and susceptibility to EV-HPV infections.

David A. Williams, J. Casanova, C. Picard, 2012, The Journal of clinical investigation.

An important role for B-cell activation factor and B cells in the pathogenesis of Sjögren's syndrome

S. Tangye, F. Mackay, J. Groom, 2007, Current opinion in rheumatology.

B Cell-Activating Factor Belonging to the TNF Family (BAFF)-R Is the Principal BAFF Receptor Facilitating BAFF Costimulation of Circulating T and B Cells1

C. Mackay, S. Tangye, M. Scott, 2004, The Journal of Immunology.

Functional STAT3 deficiency compromises the generation of human T follicular helper cells.

J. Casanova, S. Choo, Joanne M. Smart, 2012, Blood.

The Death Domain Superfamily in Intracellular Signaling of Apoptosis and Inflammation

Morgan Huse, Kim E. Nichols, Cliona M. Rooney, 2007 .

Compartmentalization of Total and Virus-Specific Tissue-Resident Memory CD8+ T Cells in Human Lymphoid Organs

S. Tangye, R. Khanna, Corey Smith, 2016, PLoS pathogens.

Regulation of cellular and humoral immune responses by the SLAM and SAP families of molecules.

S. Tangye, K. Nichols, Cindy S. Ma, 2007, Annual review of immunology.

Cutting edge: human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP.

S. Tangye, L. Lanier, J. Phillips, 1999, Journal of immunology.

Arginine methylation catalyzed by PRMT1 is required for B cell activation and differentiation

S. Richard, S. Tangye, G. Belz, 2017, Nature Communications.

Selective generation of functional somatically mutated IgM+CD27+, but not Ig isotype-switched, memory B cells in X-linked lymphoproliferative disease.

S. Pittaluga, S. Tangye, K. Nichols, 2006, The Journal of clinical investigation.

From bloodjournal.hematologylibrary.org at PENN STATE UNIVERSITY on February 23, 2013. For personal use only.

S. Tangye, T. Phan, P. Hodgkin, 2002 .

cells SAP controls the cytolytic activity of CD8+ T cells against EBV-infected

R. Clementi, S. Tangye, L. Dupré, 2013 .

SAP controls the cytolytic activity of CD8+ T cells against EBV-infected cells.

R. Clementi, S. Tangye, L. Dupré, 2005, Blood.

2B4-mediated activation of human natural killer cells.

S. Tangye, L. Lanier, J. Phillips, 2000, Molecular immunology.

Cutting Edge: Functional Requirement for SAP in 2B4-Mediated Activation of Human Natural Killer Cells as Revealed by the X-Linked Lymphoproliferative Syndrome1

S. Tangye, L. Lanier, J. Phillips, 2000, The Journal of Immunology.

Their Commitment to the Plasma Cell Human Memory B Cells Correlates with Increased Expression of CD27 on Activated

S. Tangye, P. Hodgkin, M. Corcoran, 2017 .

Immunity Characterized by Impaired Humoral Human-Immunodeficient States Transitional B Cells Is Associated with Expansion of Functionally Immature

S. Tangye, K. Nichols, J. Cannons, 2006 .

Expansion of Functionally Immature Transitional B Cells Is Associated with Human-Immunodeficient States Characterized by Impaired Humoral Immunity1

S. Tangye, K. Nichols, J. Cannons, 2006, The Journal of Immunology.

Intrinsic Defects in B Cell Development and Differentiation, T Cell Exhaustion and Altered Unconventional T Cell Generation Characterize Human Adenosine Deaminase Type 2 Deficiency

C. Wouters, S. Tangye, T. Phan, 2021, Journal of Clinical Immunology.

Transitional B cell subsets in human bone marrow

S. Tangye, W. Sewell, S. Agrawal, 2013, Clinical and experimental immunology.

Mark S. Anderson, J. Casanova, J. Fellay, 2021, The Journal of experimental medicine.

Cytokines Division-Associated and Regulated by Isotype Switching by Human B Cells Is

S. Tangye, D. Avery, Cindy S. Ma, 2002 .

Thucydides and longer-lived plasma cells.

S. Tangye, 2015, Blood.

Cytokine-Mediated Regulation of Plasma Cell Generation: IL-21 Takes Center Stage

S. Tangye, Leen Moens, 2014, Front. Immunol..

Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells

J. Casanova, S. Choo, Joanne M. Smart, 2013, The Journal of experimental medicine.

A helping hand from neutrophils in T cell–independent antibody responses?

S. Tangye, R. Brink, 2012, Nature Immunology.

IL-21 is the primary common γ chain-binding cytokine required for human B-cell differentiation in vivo.

J. Ziegler, L. Notarangelo, J. Walter, 2011, Blood.

Regulation of T follicular helper cell formation and function by antigen presenting cells.

S. Tangye, E. Deenick, R. Brink, 2011, Current opinion in immunology.

SLAM family receptors and SAP adaptors in immunity.

S. Tangye, J. Cannons, P. Schwartzberg, 2011, Annual review of immunology.

Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production

S. Tangye, J. Cyster, B. Whittle, 2009, Nature Immunology.

Human T-bet Governs Innate and Innate-like Adaptive IFN-γ Immunity against Mycobacteria

J. Casanova, A. Bousfiha, F. Ailal, 2020, Cell.

Invariant natural killer (iNK) T cell deficiency in patients with common variable immunodeficiency

S. Tangye, S. Adelstein, D. Avery, 2009, Clinical and experimental immunology.

The Ever-Increasing Array of Novel Inborn Errors of Immunity: an Interim Update by the IUIS Committee

J. Franco, A. Bousfiha, C. Picard, 2021, Journal of Clinical Immunology.

Circulating TFH cells, serological memory, and tissue compartmentalization shape human influenza-specific B cell immunity

S. Tangye, K. Laurie, L. Loh, 2018, Science Translational Medicine.

T follicular helper (TFH) cells in normal and dysregulated immune responses.

C. Mackay, S. Tangye, C. King, 2008, Annual review of immunology.

Impaired humoral immunity in X-linked lymphoproliferative disease is associated with defective IL-10 production by CD4+ T cells.

S. Tangye, P. Hodgkin, K. Nichols, 2005, The Journal of clinical investigation.

Hyper-IgE Syndrome due to an Elusive Novel Intronic Homozygous Variant in DOCK8

S. Kummerfeld, S. Tangye, G. Uzel, 2021, Journal of clinical immunology.

Regulated by IL-4 IgA by Human Naive B Cells Is Differentially IL-21-Induced Isotype Switching to IgG and

S. Tangye, D. Avery, Cindy S. Ma, 2008 .

CD8+ T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph

S. Tangye, F. Luciani, C. Szeto, 2020, Nature Communications.

Functional Consequences of Interactions between Human NKR-P1A and Its Ligand LLT1 Expressed on Activated Dendritic Cells and B Cells1

S. Tangye, L. Lanier, Yong‐jun Liu, 2008, The Journal of Immunology.

Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs

Mark S. Anderson, Chun Jimmie Ye, Gabriela K. Fragiadakis, 2022, Science immunology.

Three Copies of Four Interferon Receptor Genes Underlie a Mild Type I Interferonopathy in Down Syndrome

D. Chaussabel, A. Munnich, J. Casanova, 2020, Journal of Clinical Immunology.

A loss-of-function IFNAR1 allele in Polynesia underlies severe viral diseases in homozygotes

Consuelo D. Quinto-Cortés, D. Weeks, E. Hagelberg, 2022, The Journal of experimental medicine.

An essential role for the Zn2+ transporter ZIP7 in B cell development

J. Casanova, G. Rutter, M. van der Burg, 2019, Nature Immunology.

Phosphatidylinositol 3-kinase signaling and immune regulation: insights into disease pathogenesis and clinical implications

S. Tangye, E. Deenick, T. Nguyen, 2021, Expert review of clinical immunology.

Immune Dysregulation and Disease Pathogenesis due to Activating Mutations in PIK3CD—the Goldilocks’ Effect

S. Tangye, G. Uzel, E. Deenick, 2019, Journal of Clinical Immunology.

Flow Cytometric-Based Analysis of Defects in Lymphocyte Differentiation and Function Due to Inborn Errors of Immunity

S. Tangye, Cindy S. Ma, 2019, Front. Immunol..

lymphoproliferative disease patients cells: IgM+IgD+ CD27+ B cells harbour the virus in X-linked Epstein-Barr virus persistence in the absence of conventional memory B

S. Tangye, A. Rickinson, Cindy S. Ma, 2013 .

Epstein-Barr virus persistence in the absence of conventional memory B cells: IgM+IgD+CD27+ B cells harbor the virus in X-linked lymphoproliferative disease patients.

S. Tangye, A. Rickinson, Cindy S. Ma, 2008, Blood.

Human DOCK2 Deficiency: Report of a Novel Mutation and Evidence for Neutrophil Dysfunction

J. Casanova, L. Notarangelo, S. Tangye, 2019, Journal of Clinical Immunology.

Increased expression of CD27 on activated human memory B cells correlates with their commitment to the plasma cell lineage

S. Tangye, P. Hodgkin, F. Mackay, 2005, The Journal of Immunology.

Contribution of stromal cells to the migration, function and retention of plasma cells in human spleen: potential roles of CXCL12, IL‐6 and CD54

C. Mackay, S. Tangye, D. Avery, 2005, European journal of immunology.

Staying alive: regulation of plasma cell survival.

S. Tangye, 2011, Trends in immunology.

Human T follicular helper cells in primary immunodeficiencies

S. Tangye, G. Uzel, Cindy S. Ma, 2014, Current opinion in pediatrics.

T Follicular Helper Cells + CXCR 5 Predominant Role of IL-21 Produced by Cell Differentiation into Ig-Secreting Cells : Cytokine-Mediated Regulation of Human B and

S. Tangye, L. Corcoran, Ying Li, 2007 .

Human IgM+CD27+ B Cells: Memory B Cells or “Memory” B Cells?1

S. Tangye, Kim L. Good, 2007, The Journal of Immunology.

Kinetics of Human B Cell Behavior and Amplification of Proliferative Responses following Stimulation with IL-211

S. Tangye, Vanessa L. Bryant, V. Bryant, 2006, The Journal of Immunology.

Divide and conquer: the importance of cell division in regulating B‐cell responses

S. Tangye, P. Hodgkin, 2004, Immunology.

This information is current as Responses Mechanism for Enhanced Secondary Immune Naive and Memory Human B Cells as a Intrinsic Differences in the Proliferation of

S. Tangye, P. Hodgkin, E. Deenick, 2002 .

Leukaemic CD5+ B‐cell apoptosis: co‐incidence of cell death and DNA fragmentation with reduced bcl‐2 expression

S. Tangye, R. Raison, 1996, British journal of haematology.

CD4+ T cells that help B cells - a proposal for uniform nomenclature.

S. Tangye, N. Fazilleau, M. Linterman, 2021, Trends in immunology.

FAS Inactivation Releases Unconventional Germinal Center B Cells that Escape Antigen Control and Drive IgE and Autoantibody Production.

A. Strasser, S. Tangye, T. Phan, 2015, Immunity.

Interleukin-10 inhibits the in vitro proliferation of human activated leukemic CD5+ B-cells.

S. Tangye, R. Raison, K. Weston, 1998, Leukemia & lymphoma.

Molecular and cellular pathogenesis of X‐linked lymphoproliferative disease

S. Tangye, K. Nichols, J. Cannons, 2005, Immunological reviews.

Persistence of naive CD45RA+ regulatory T cells in adult life.

S. Tangye, S. Alexander, R. Nanan, 2006, Blood.

Regulation of NKT cell development by SAP, the protein defective in XLP

S. Tangye, P. Stein, K. Nichols, 2005, Nature Medicine.

Signaling Protein SAP Phosphatase SHP-2 and the Adaptor Cell Receptor , Recruits the Protein Tyrosine Cutting Edge : Human 2 B 4 , an Activating NK

Sutherland, S. Tangye, L. Lanier, 1999 .

A subset of interleukin-21+ chemokine receptor CCR9+ T helper cells target accessory organs of the digestive system in autoimmunity.

S. Tangye, W. E. Hughes, C. King, 2011, Immunity.

A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity

D. Chaussabel, J. Casanova, P. Li, 2018, Science Immunology.

Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling.

S. Tangye, P. Schwartzberg, E. Deenick, 2010, Immunity.

IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells

S. Tangye, D. Danilenko, M. Batten, 2010, The Journal of experimental medicine.

STAT3 mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8 + T cell memory formation and function

S. Choo, Joanne M. Smart, C. Picard, 2013 .

Humoral Immune Responses CD4 T Cells and Their Relevance for CXCR5 Expressing Human Central Memory

C. Mackay, S. Tangye, D. Jarrossay, 2011 .

Genomic Spectrum and Phenotypic Heterogeneity of Human IL-21 Receptor Deficiency

S. Tangye, O. Sanal, I. Tezcan, 2021, Journal of Clinical Immunology.

Clinical, molecular, and cellular immunologic findings in patients with SP110-associated veno-occlusive disease with immunodeficiency syndrome.

J. Ziegler, S. Tangye, J. Church, 2012, The Journal of allergy and clinical immunology.

JEM career launchpad

S. Tangye, J. Kipnis, A. Bigas, 2021, The Journal of experimental medicine.

Automatic generation of lymphocyte heterogeneity: Division‐dependent changes in the expression of CD27, CCR7 and CD45 by activated human naive CD4+ T cells are independently regulated

S. Tangye, P. Hodgkin, Cindy S. Ma, 2004, Immunology and cell biology.

Expansion of somatically reverted memory CD8+ T cells in patients with X-linked lymphoproliferative disease caused by selective pressure from Epstein-Barr virus

V. Lougaris, S. Choo, Joanne M. Smart, 2012, The Journal of experimental medicine.

STAT3 is required for IL-21-induced secretion of IgE from human naive B cells.

S. Tangye, M. Cook, D. Avery, 2008, Blood.

DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice

J. Casanova, Joanne M. Smart, C. Picard, 2011, The Journal of experimental medicine.

DOCK 8 de ! ciency impairs CD 8 T cell survival and function in humans and mice

J. Casanova, Joanne M. Smart, C. Picard, 2011 .

DOCK 8 deficiency impairs CD 8 T cell survival and function in humans and mice

J. Casanova, Joanne M. Smart, C. Picard, 2011 .

A recurrent dominant negative E47 mutation causes agammaglobulinemia and BCR(-) B cells.

J. Casanova, S. Tangye, B. Boisson, 2013, The Journal of clinical investigation.

What can primary immunodeficiencies teach us about Th9 cell differentiation and function?

S. Tangye, Cindy S. Ma, Lisa Worley, 2018, Immunology and cell biology.

Extended clinical and immunological phenotype and transplant outcome in CD27 and CD70 deficiency.

Andrew J. Oler, S. Choo, S. Tangye, 2020, Blood.

Primary immunodeficiencies reveal the molecular requirements for effective host defense against EBV infection.

S. Tangye, S. Latour, 2020, Blood.

Combined immunodeficiency and Epstein-Barr virus–induced B cell malignancy in humans with inherited CD70 deficiency

J. McElwee, J. Casanova, S. Tangye, 2017, The Journal of experimental medicine.

Calcineurin-dependent negative regulation of CD94/NKG2A expression on naive CD8+ T cells.

J. Sprent, S. Tangye, C. King, 2011, Blood.

Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses

S. Tangye, V. Cerundolo, S. Nutt, 2011, Nature Immunology.

The Expanding Spectrum of NFkB1 Deficiency

S. Tangye, Vanessa L. Bryant, V. Bryant, 2016, Journal of Clinical Immunology.

Advances in IL-21 biology - enhancing our understanding of human disease.

S. Tangye, 2015, Current opinion in immunology.

Signaling lymphocytic activation molecule (SLAM)/SLAM-associated protein pathway regulates human B-cell tolerance.

C. Cunningham-Rundles, S. Tangye, J. Church, 2014, The Journal of allergy and clinical immunology.

Regulation of the germinal center and humoral immunity by interleukin-21

S. Tangye, Cindy S. Ma, 2019, The Journal of experimental medicine.

Defective protein prenylation is a diagnostic biomarker of mevalonate kinase deficiency.

J. Center, S. Tangye, T. Phan, 2017, The Journal of allergy and clinical immunology.

Mevalonate kinase deficiency leads to decreased prenylation of Rab GTPases

Naveid A Ali, J. Ziegler, S. Tangye, 2016, Immunology and cell biology.

Autoimmunity: IL‐21: a new player in Th17‐cell differentiation

S. Tangye, E. Deenick, 2007, Immunology and cell biology.

Therapeutic implications of advances in our understanding of transitional B-cell development in humans

S. Tangye, S. Suryani, Santi Suryani, 2010, Expert review of clinical immunology.

Immunology: Cytotoxic T cells that escape exhaustion

S. Tangye, Cindy S. Ma, 2016, Nature.

Activating mutations in PIK3CD disrupt the differentiation and function of human and murine CD4+ T cells.

L. Notarangelo, S. Choo, Joanne M. Smart, 2019, The Journal of allergy and clinical immunology.

Activating mutations in PIK3CD and murine CD4 + T cells

L. Notarangelo, S. Choo, Joanne M. Smart, 2019 .

The Integrin LFA-1 Controls T Follicular Helper Cell Generation and Maintenance.

Irah L. King, S. Tangye, Jim Miller, 2016, Immunity.

Correction: Memory B cells: Effectors of long‐lived immune responses

S. Tangye, D. Tarlinton, 2009 .

Autoimmunity: IL‐21: a new player in Th17‐cell differentiation

S. Tangye, E. Deenick, 2008 .

Is it dead or alive? TLR8 can tell

S. Tangye, 2018, Nature Immunology.

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

P. Gregersen, J. Casanova, L. Rowen, 2022, Proceedings of the National Academy of Sciences of the United States of America.

The risk of COVID-19 death is much greater and age-dependent with type I IFN autoantibodies

Mark S. Anderson, J. Casanova, L. Rowen, 2022, Research square.

Human T-bet governs the generation of a distinct subset of CD11chighCD21low B cells

J. Casanova, A. Bousfiha, S. Tangye, 2022, Science Immunology.

Human Inborn Errors of Immunity: 2022 Update on the Classification from the International Union of Immunological Societies Expert Committee

J. Casanova, J. Franco, A. Bousfiha, 2022, Journal of Clinical Immunology.

Human immunity against EBV—lessons from the clinic

S. Tangye, U. Palendira, E. Edwards, 2017, The Journal of experimental medicine.

Molecular Pathogenesis of EBV Susceptibility in XLP as Revealed by Analysis of Female Carriers with Heterozygous Expression of SAP

S. Choo, S. Tangye, T. Phan, 2011, PLoS biology.

CD148: a receptor-type protein tyrosine phosphatase involved in the regulation of human T cell activation.

S. Tangye, L. Lanier, J. Phillips, 1998, Journal of immunology.

Human T Cell Activation Phosphatase Involved in the Regulation of CD 148 : A Receptor-Type Protein Tyrosine

S. Tangye, L. Lanier, J. Phillips, 1998 .

T cell–B cell interactions in primary immunodeficiencies

S. Tangye, E. Deenick, U. Palendira, 2012, Annals of the New York Academy of Sciences.

Helping the helpers!

S. Tangye, Cindy S. Ma, 2009, Immunity.

the Hyper-IgE Syndrome Lymphocyte Differentiation as Revealed by Insights into the Role of STAT3 in Human

S. Tangye, M. Cook, D. Fulcher, 2008 .

Human Th9 cells: inflammatory cytokines modulate IL‐9 production through the induction of IL‐21

S. Tangye, E. Deenick, Cindy S. Ma, 2010, Immunology and cell biology.

Negative regulation of human T cell activation by the receptor-type protein tyrosine phosphatase CD148.

S. Tangye, L. Lanier, J. Phillips, 1998, Journal of immunology.

Activated PI3Kδ breaches multiple B cell tolerance checkpoints and causes autoantibody production

L. Notarangelo, S. Choo, Joanne M. Smart, 2019, The Journal of experimental medicine.

Memory B cells: total recall.

S. Tangye, T. Phan, 2017, Current opinion in immunology.

IgM expressed by leukemic CD5+ B cells binds mouse immunoglobulin light chain

S. Tangye, M. Morris, Alison Smith, 2001, Journal of molecular recognition : JMR.

Cytokines and cross‐linking of sIgM augment PMA‐induced activation of human leukaemic CD5+ B cells

S. Tangye, R. Raison, K. Weston, 1997, Immunology and cell biology.

Human cytokines suppress apoptosis of leukaemic CD5+ B cells and preserve expression of bcl‐2

S. Tangye, R. Raison, 1997, Immunology and cell biology.

Phorbol ester activates CD5+ leukaemic B cells via a T cell‐independent mechanism

S. Tangye, R. Raison, K. Weston, 1995, Immunology and cell biology.

In Vitro Regulation of Growth, Differentiation and Survival of Leukemic CD5+ B Cells

S. Tangye, 1995 .

DOCK8 is critical for the survival and function of NKT cells.

Joanne M. Smart, S. Tangye, H. Lockstone, 2013, Blood.

Molecular and functional characterization of mouse signaling lymphocytic activation molecule (SLAM): differential expression and responsiveness in Th1 and Th2 cells.

S. Tangye, L. Lanier, B. Cocks, 1999, Journal of immunology.

Responsiveness in Th 1 and Th 2 Cells Molecule ( SLAM ) : Differential Expression of Mouse Signaling Lymphocytic Activation Molecular and Functional Characterization

S. Tangye, B. Cocks, K. Nichols, 1999 .

Missense mutations in SH2D1A identified in patients with X-linked lymphoproliferative disease differentially affect the expression and function of SAP.

S. Tangye, K. Nichols, Nathan J. Hare, 2006, International immunology.

Contribution to Human T Cell Activation Domain-Containing Proteins and Their Between CD84 and Src Homology 2 Functional Requirements for Interactions

S. Tangye, K. Nichols, Nathan J. Hare, 2003 .

Severe COVID‐19 represents an undiagnosed primary immunodeficiency in a high proportion of infected individuals

S. Tangye, Adam W. Bartlett, P. Gray, 2022, Clinical & translational immunology.

Everolimus-Induced Remission of Classic Kaposi’s Sarcoma Secondary to Cryptic Splicing Mediated CTLA4 Haploinsufficiency

S. Tangye, B. Gloss, T. Phan, 2020, Journal of Clinical Immunology.

Cell membrane associated free kappa light chains are found on a subset of tonsil and in vitro-derived plasmablasts.

S. Tangye, Darren R. Jones, R. Raison, 2014, Human immunology.

Immunology: Helpful T cells are sticky

S. Tangye, E. Deenick, 2008, Nature.

Cells Their Role as Non-Th 1 / Th 2 Effector Cells ReflectingDistinctive Transcriptional Profile , T Follicular Helper Cells Express a

C. Mackay, S. Tangye, M. Rolph, 2004 .

Hematopoietic Stem Cell Transplantation Cures Chronic Aichi Virus Infection in a Patient with X-linked Agammaglobulinemia

M. Van Ranst, S. Tangye, K. Jansen, 2021, Journal of Clinical Immunology.

Hematopoietic stem cell transplant effectively rescues lymphocyte differentiation and function in DOCK8-deficient patients inactivating mutations in DOCK8 cause a combined immunodeficiency characterized by severe pathogen infections,

J. Casanova, J. Ziegler, S. Choo, 2019 .

Chronic Aichi Virus Infection in a Patient with X-Linked Agammaglobulinemia

M. Van Ranst, S. Tangye, D. Mekahli, 2018, Journal of Clinical Immunology.

Human inborn errors of immunity to herpes viruses.

J. Casanova, S. Tangye, Shen-Ying Zhang, 2020, Current opinion in immunology.

Functional Requirements for Interactions Between CD84 and Src Homology 2 Domain-Containing Proteins and Their Contribution to Human T Cell Activation 1

S. Tangye, K. Nichols, Nathan J. Hare, 2003, The Journal of Immunology.

IL-27 Directly Enhances Germinal Center B Cell Activity and Potentiates Lupus in Sanroque Mice

S. Tangye, M. Batten, C. King, 2016, The Journal of Immunology.

CD148 T Cell Activation by the Receptor-Type Cutting Edge: Negative Regulation of Human

Jun Wu, S. Tangye, L. Lanier, 1998 .

Identification of germline monoallelic mutations in IKZF2 in patients with immune dysregulation

F. Rieux-Laucat, S. Tangye, M. Haimel, 2021, Blood advances.

Systemic Inflammation and Myelofibrosis in a Patient with Takenouchi-Kosaki Syndrome due to CDC42 Tyr64Cys Mutation

S. Tangye, M. Proesmans, I. Meyts, 2020, Journal of Clinical Immunology.

Human type I IFN deficiency does not impair B cell response to SARS-CoV-2 mRNA vaccination

J. Casanova, M. Zins, S. Tangye, 2022, The Journal of experimental medicine.

Human plasma C3 is essential for the development of memory B, but not T, lymphocytes.

S. Tangye, M. Kolev, S. Rodríguez de Córdoba, 2017, The Journal of allergy and clinical immunology.

Dedicator of cytokinesis 8–deficient CD4+ T cells are biased to a TH2 effector fate at the expense of TH1 and TH17 cells

J. Casanova, J. Orange, J. Ziegler, 2017, The Journal of allergy and clinical immunology.

DOCK 8-Deficient CD 4 + T Cells are Biased to a Th 2 Effector Fate at the Expense of Th 1 and Th 17 Cells

J. Ziegler, Joanne M. Smart, S. Tangye, 2016 .

Corrigendum: Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production

S. Tangye, J. Cyster, B. Whittle, 2010, Nature Immunology.

A Novel Targeted Amplicon Next-Generation Sequencing Gene Panel for the Diagnosis of Common Variable Immunodeficiency Has a High Diagnostic Yield: Results from the Perth CVID Cohort Study.

M. John, S. Tangye, L. D'Orsogna, 2022, The Journal of molecular diagnostics : JMD.

Circulating T and B Cells Receptor Facilitating BAFF Costimulation of BAFFTNF Family ( BAFF )-R Is the Principal B Cell-Activating Factor Belonging to the

C. Mackay, S. Tangye, M. Scott, 2004 .

Differential expression of CD21 identifies developmentally and functionally distinct subsets of human transitional B cells.

S. Tangye, S. Suryani, M. Wong, 2010, Blood.

STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological NKG2Dhi CD8+ T cell dysregulation and accumulation.

Timothy J. Peters, S. Mustjoki, S. Tangye, 2022, Immunity.

Genetic susceptibility to EBV infection: insights from inborn errors of immunity

S. Tangye, 2020, Human Genetics.

XLP: Clinical Features and Molecular Etiology due to Mutations in SH2D1A Encoding SAP

S. Tangye, 2014, Journal of Clinical Immunology.

Impact of SARS-CoV-2 infection and COVID-19 on patients with inborn errors of immunity

Mark S. Anderson, J. Casanova, J. Fellay, 2022, Journal of Allergy and Clinical Immunology.

Mechanisms underlying host defense and disease pathology in response to severe acute respiratory syndrome (SARS)-CoV2 infection: insights from inborn errors of immunity

S. Tangye, I. Meyts, G. Bucciol, 2021, Current opinion in allergy and clinical immunology.

Emergence and antibody evasion of BQ and BA.2.75 SARS-CoV-2 sublineages in the face of maturing antibody breadth at the population level

S. Tangye, M. Wong, S. Turville, 2022, medRxiv.

Protein Tyrosine Phosphatase CD148-Mediated Inhibition of T-Cell Receptor Signal Transduction Is Associated with Reduced LAT and Phospholipase C g 1 Phosphorylation

S. Tangye, R. Majeti, A. Weiss, 2001 .

"Are you gonna go my way?"-Decisions at the Tfh-B cell interface.

S. Tangye, K. Warnatz, 2022, Immunity.

Cerebral Vasculitis in X-linked Lymphoproliferative Disease Cured by Matched Unrelated Cord Blood Transplant

J. Ziegler, S. Choo, S. Tangye, 2015, Journal of Clinical Immunology.

Epstein-Barr virus persistence in the absence of conventional memory B cells: IgM (cid:1) IgD (cid:1) CD27 (cid:1) B cells harbor the virus in X-linked lymphoproliferative disease patients

S. Tangye, A. Rickinson, Cindy S. Ma, 2008 .

CD84 is up‐regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT‐2

S. Tangye, P. Hodgkin, D. Avery, 2002, European journal of immunology.

Src Homology 2 Domain-Containing Gene 1A (SH2D1A)

S. Tangye, K. Nichols, 2002 .

Signaling Lymphocytic Activation Molecule (SLAM)

S. Tangye, K. Nichols, 2002 .

To B1 or not to B1: that really is still the question!

S. Tangye, 2013, Blood.

Memory B cells: Effectors of long‐lived immune responses

S. Tangye, D. Tarlinton, 2009, European journal of immunology.

Follicular B helper T cells in antibody responses and autoimmunity

C. Mackay, S. Tangye, C. Vinuesa, 2005, Nature Reviews Immunology.

Coronavirus disease 2019 in patients with inborn errors of immunity: An international study

B. Lambrecht, A. Fischer, E. López-Granados, 2020, Journal of Allergy and Clinical Immunology.

Molecular requirements for human lymphopoiesis as defined by inborn errors of immunity

S. Tangye, E. Della Mina, A. Guérin, 2021, Stem cells.

Human Inborn Errors of Immunity: 2019 Update of the IUIS Phenotypical Classification

J. Casanova, J. Franco, A. Bousfiha, 2020, Journal of Clinical Immunology.

Human Inborn Errors of Immunity: 2019 Update on the Classification from the International Union of Immunological Societies Expert Committee

J. Casanova, J. Franco, A. Bousfiha, 2020, Journal of Clinical Immunology.

Correction to: Human Inborn Errors of Immunity: 2019 Update on the Classification from the International Union of Immunological Societies Expert Committee

J. Casanova, J. Franco, A. Bousfiha, 2020, Journal of Clinical Immunology.

Human IFN-γ immunity to mycobacteria is governed by both IL-12 and IL-23

J. Casanova, A. Sette, S. Tangye, 2018, Science Immunology.

Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies.

J. Casanova, J. Ziegler, Joanne M. Smart, 2015, The Journal of allergy and clinical immunology.

Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus.

S. Tangye, G. Huttley, T. Vyse, 2010, Arthritis and rheumatism.

The 2022 Update of IUIS Phenotypical Classification for Human Inborn Errors of Immunity

J. Franco, A. Bousfiha, L. Jeddane, 2022, Journal of Clinical Immunology.

Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3

S. Tangye, M. Cook, B. Grimbacher, 2008, The Journal of experimental medicine.

IRF4 haploinsufficiency in a family with Whipple’s disease

D. Chaussabel, J. Casanova, S. Boughorbel, 2017, bioRxiv.

Tuberculosis and impaired IL-23–dependent IFN-γ immunity in humans homozygous for a common TYK2 missense variant

J. Casanova, H. Ochs, S. Tangye, 2018, Science Immunology.

Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy

Mark M. Davis, J. Casanova, L. Notarangelo, 2021, Cell.

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Steven M. Holland, Amelia Licari, Gian Luigi Marseglia, 2020, Science.

Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4

J. B. Oliveira, J. Hughes, J. McElwee, 2014, Science.

Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria

Mohamed N. Jeljeli, J. Casanova, L. Kremer, 2023, Cell.

BAFF, APRIL and human B cell disorders.

S. Tangye, Vanessa L. Bryant, V. Bryant, 2006, Seminars in immunology.

Hematopoietic stem cell transplant effectively rescues lymphocyte differentiation and function in DOCK8-deficient patients.

J. Casanova, J. Ziegler, S. Choo, 2019, JCI insight.

Hematopoietic stem cell transplant effectively rescues lymphocyte differentiation and function in DOCK8 2

J. Casanova, J. Ziegler, S. Choo, 2019 .

Hematopoietic stem cell transplant effectively rescues lymphocyte differentiation and function in DOCK 8-deficient patients

J. Casanova, J. Ziegler, S. Choo, 2019 .

Human inborn errors of the actin cytoskeleton affecting immunity: way beyond WAS and WIP

S. Tangye, I. Meyts, Cindy S. Ma, 2019, Immunology and cell biology.

Human DOCK2 Deficiency: Report of a Novel Mutation and Evidence for Neutrophil Dysfunction

J. Casanova, L. Notarangelo, S. Tangye, 2019, Journal of Clinical Immunology.

Mutations affecting the actin regulator WD repeat–containing protein 1 lead to aberrant lymphoid immunity

M. van der Burg, S. Tangye, Javier Rey-Barroso, 2018, The Journal of allergy and clinical immunology.

International Union of Immunological Societies: 2017 Primary Immunodeficiency Diseases Committee Report on Inborn Errors of Immunity

Steven M. Holland, Christoph Klein, Amos Etzioni, 2017, Journal of Clinical Immunology.

Human Inborn Errors of Immunity: 2019 Update of the IUIS Phenotypical Classification

J. Casanova, J. Franco, A. Bousfiha, 2020, Journal of Clinical Immunology.

Human Inborn Errors of Immunity: 2019 Update on the Classification from the International Union of Immunological Societies Expert Committee

J. Casanova, J. Franco, A. Bousfiha, 2020, Journal of Clinical Immunology.

Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity

Benjamin T. Porebski, G. Nolan, M. Cox, 2019, Nature Immunology.

Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency

J. B. Oliveira, S. Pittaluga, S. Holland, 2013, Nature Immunology.

Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations

J. Casanova, A. Sette, L. Notarangelo, 2015, Science.

Memory B cells are reactivated in subcapsular proliferative foci of lymph nodes

S. Tangye, F. Luciani, T. Phan, 2018, Nature Communications.

CCR6 Defines Memory B Cell Precursors in Mouse and Human Germinal Centers, Revealing Light‐Zone Location and Predominant Low Antigen Affinity

S. Tangye, M. Dinger, J. Maag, 2017, Immunity.

Human T-bet Governs Innate and Innate-like Adaptive IFN-γ Immunity against Mycobacteria

J. Casanova, A. Bousfiha, F. Ailal, 2020, Cell.

Circulating precursor CCR7(lo)PD-1(hi) CXCR5⁺ CD4⁺ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure.

C. Mackay, S. Tangye, G. Belz, 2013, Immunity.

Early commitment of naïve human CD4+ T cells to the T follicular helper (TFH) cell lineage is induced by IL‐12

S. Tangye, E. Deenick, D. Avery, 2009, Immunology and cell biology.

Immune Dysregulation and Disease Pathogenesis due to Activating Mutations in PIK3CD—the Goldilocks’ Effect

S. Tangye, G. Uzel, E. Deenick, 2019, Journal of Clinical Immunology.

Germline-activating mutations in PIK3CD compromise B cell development and function

W. Shi, S. Choo, S. Holland, 2018, The Journal of experimental medicine.

Cytokine-mediated STAT-dependent pathways underpinning human B-cell differentiation and function.

S. Tangye, Cindy S. Ma, K. Pathmanandavel, 2023, Current opinion in immunology.

IL-21 signalling via STAT3 primes human naive B cells to respond to IL-2 to enhance their differentiation into plasmablasts.

J. Casanova, J. Ziegler, Joanne M. Smart, 2013, Blood.

Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood

J. Casanova, E. Cesarman, C. Picard, 2013, The Journal of experimental medicine.

A Division-Linked Mechanism for the Rapid Generation of Ig-Secreting Cells from Human Memory B Cells1

S. Tangye, P. Hodgkin, D. Avery, 2003, The Journal of Immunology.

Resting Human Memory B Cells Are Intrinsically Programmed for Enhanced Survival and Responsiveness to Diverse Stimuli Compared to Naive B Cells1

S. Tangye, D. Avery, Kim L. Good, 2009, The Journal of Immunology.

Atypical Autosomal Recessive AID Deficiency—Yet Another Piece of the Hyper-IgM Puzzle

S. Tangye, Erika Della Mina, 2022, Journal of Clinical Immunology.

Dual T cell– and B cell–intrinsic deficiency in humans with biallelic RLTPR mutations

J. Casanova, L. Notarangelo, E. Crestani, 2016, The Journal of experimental medicine.

Tissue‐resident regulatory T cells accumulate at human barrier lymphoid organs

Thomas S. Watkins, S. Tangye, W. Britton, 2021, Immunology and cell biology.

This information is current as X-Linked Lymphoproliferative Syndrome Natural Killer Cells as Revealed by the SAP in 2B4-Mediated Activation of Human Cutting Edge: Functional Requirement for

Kim E. Nichols, Lewis L. Lanier, Stuart G. Tangye, 2013 .

The X-linked lymphoproliferative disease gene product SAP associates with PAK-interacting exchange factor and participates in T cell activation

Stuart G. Tangye, Jun Wu, S. Tangye, 2006, Proceedings of the National Academy of Sciences.

The CD2-subset of the Ig superfamily of cell surface molecules: receptor-ligand pairs expressed by NK cells and other immune cells.

S. Tangye, L. Lanier, J. Phillips, 2000, Seminars in immunology.

High Th2 cytokine levels and upper airway inflammation in human inherited T-bet deficiency

J. Casanova, A. Bousfiha, S. Tangye, 2021, The Journal of experimental medicine.

Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome

David R. Murdock, J. Rosenfeld, B. Lambrecht, 2020, The Journal of experimental medicine.

Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome

D. Chaussabel, J. Casanova, A. Bousfiha, 2015, The Journal of experimental medicine.

Studying severe long COVID to understand post-infectious disorders beyond COVID-19

Mark S. Anderson, P. Gregersen, J. Casanova, 2022, Nature Medicine.

Decreased expression of Krüppel-like factors in memory B cells induces the rapid response typical of secondary antibody responses

S. Tangye, Kim L. Good, 2007, Proceedings of the National Academy of Sciences.

A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection

Jacques Fellay, Aurora Pujol, Claire Redin, 2020, Cell.

The origins, function, and regulation of T follicular helper cells

S. Tangye, M. Batten, E. Deenick, 2012, The Journal of experimental medicine.

Activating PIK3CD mutations impair human cytotoxic lymphocyte differentiation and function and EBV immunity

S. Choo, S. Holland, S. Tangye, 2019, The Journal of allergy and clinical immunology.

The role of the BAFF/APRIL system in B cell homeostasis and lymphoid cancers.

S. Tangye, F. Mackay, 2004, Current opinion in pharmacology.

Inherited GINS1 deficiency underlies growth retardation along with neutropenia and NK cell deficiency

J. Casanova, C. Picard, S. Tangye, 2017, The Journal of clinical investigation.

Naïve and memory B cells exhibit distinct biochemical responses following BCR engagement

S. Tangye, Leen Moens, A. Kane, 2016, Immunology and cell biology.

Preview : Published ahead of advance online publication Naı̈ve and memory B cells exhibit distinct biochemical responses following BCR engagement

S. Tangye, Leen Moens, A. Kane, 2016 .

Intrinsic Differences in the Proliferation of Naive and Memory Human B Cells as a Mechanism for Enhanced Secondary Immune Responses1

Elissa K. Deenick, Philip D. Hodgkin, Stuart G. Tangye, 2003, The Journal of Immunology.

Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

Mark S. Anderson, P. Gregersen, R. Nussbaum, 2021, Science Immunology.

Reduced memory B‐cell populations in boys with B‐cell dysfunction after bone marrow transplantation for X‐linked severe combined immunodeficiency

J. Ziegler, S. Tangye, R. Ffrench, 2001, British journal of haematology.

Signal Transducer and Activator of Transcription 3 Limits Epstein-Barr Virus Lytic Activation in B Lymphocytes

S. Tangye, P. Farrell, A. Freeman, 2013, Journal of Virology.

IL-21-Induced Isotype Switching to IgG and IgA by Human Naive B Cells Is Differentially Regulated by IL-41

S. Tangye, R. de Waal Malefyt, D. Avery, 2008, The Journal of Immunology.

Human genetic and immunological determinants of critical COVID-19 pneumonia

Mark S. Anderson, P. Gregersen, J. Casanova, 2022, Nature.

Cerebral Vasculitis in X-linked Lymphoproliferative Disease Cured by Matched Unrelated Cord Blood Transplant

J. Ziegler, S. Choo, S. Tangye, 2015, Journal of Clinical Immunology.

Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child

J. Casanova, M. Glickman, J. Wolchok, 2021, Nature Medicine.

Somatic reversion of pathogenic DOCK8 variants alters lymphocyte differentiation and function to effectively cure DOCK8 deficiency.

A. Fischer, J. Ziegler, Joanne M. Smart, 2020, The Journal of clinical investigation.

International Union of Immunological Societies: 2017 Primary Immunodeficiency Diseases Committee Report on Inborn Errors of Immunity

J. Casanova, J. Franco, A. Bousfiha, 2017, Journal of Clinical Immunology.

The expansion of human T-bethighCD21low B cells is T cell dependent

J. Casanova, M. Boerries, M. van der Burg, 2021, Science Immunology.

Overactive STAT3 drives accumulation of disease-associated CD21low B cells

Timothy J. Peters, S. Mustjoki, S. Tangye, 2021, bioRxiv.

Primary immune deficiencies affecting lymphocyte differentiation: lessons from the spectrum of resulting infections.

S. Tangye, M. Cook, 2009, International immunology.

Human CD8+ T cell cross-reactivity across influenza A, B and C viruses

David F. Boyd, S. Tangye, F. Luciani, 2019, Nature Immunology.

T Follicular Helper Cells Express a Distinctive Transcriptional Profile, Reflecting Their Role as Non-Th1/Th2 Effector Cells That Provide Help for B Cells1

C. Mackay, S. Tangye, M. Rolph, 2004, The Journal of Immunology.

Human STAT3 variants underlie autosomal dominant hyper-IgE syndrome by negative dominance

J. Casanova, A. Bousfiha, C. Picard, 2021, The Journal of experimental medicine.

A deep intronic splice mutation of STAT3 underlies hyper IgE syndrome by negative dominance

J. Casanova, C. Picard, S. Tangye, 2019, Proceedings of the National Academy of Sciences.

B cell-intrinsic requirement for STK4 in humoral immunity in mice and human subjects.

L. Notarangelo, S. Tangye, T. Phan, 2019, The Journal of allergy and clinical immunology.

STAT3 is a central regulator of lymphocyte differentiation and function.

S. Tangye, G. Uzel, M. Cook, 2014, Current opinion in immunology.

Insights into the Role of STAT3 in Human Lymphocyte Differentiation as Revealed by the Hyper-IgE Syndrome1

S. Tangye, M. Cook, D. Fulcher, 2009, The Journal of Immunology.

Hyper-IgE Syndrome Lymphocyte Differentiation as Revealed by Insights into the Role of STAT 3 in Human

S. Tangye, M. Cook, D. Fulcher, 2008 .

Ar Ticle B Cell–intrinsic Signaling through Il-21 Receptor and Stat3 Is Required for Establishing Long-lived Antibody Responses in Humans Engagement of Cytokine Receptors by Specific Ligands Activate Janus Kinase–signal Transducer and Activator of Transcription (stat) Signaling Pathways. the Exact R

Sami Al-Hajjar, J. Casanova, S. Choo, 2022 .

XLP: Clinical Features and Molecular Etiology due to Mutations in SH2D1A Encoding SAP

S. Tangye, 2014, Journal of Clinical Immunology.

Hyper-IgE Syndrome due to an Elusive Novel Intronic Homozygous Variant in DOCK8

S. Kummerfeld, S. Tangye, G. Uzel, 2021, Journal of Clinical Immunology.

Disruption of an anti-mycobacterial circuit between dendritic and Th cells in human SPPL2a deficiency

J. Casanova, M. Nussenzweig, A. Sette, 2018, Nature Immunology.

Increased Expression of CD27 on Activated Human Memory B Cells Correlates with Their Commitment to the Plasma Cell Lineage1

S. Tangye, P. Hodgkin, F. Mackay, 2005, The Journal of Immunology.

HumanGeneration of Ig-Secreting Cells from A Division-Linked Mechanism for the Rapid

S. Tangye, D. Avery, 2002 .

Cytokine-Mediated Regulation of Human Lymphocyte Development and Function: Insights from Primary Immunodeficiencies

S. Tangye, E. Deenick, Cindy S. Ma, 2017, The Journal of Immunology.

Insights from Primary Immunodeficiencies Lymphocyte Development and Function : Cytokine-Mediated Regulation of Human

S. Tangye, E. Deenick, Cindy S. Ma, 2017 .

Isotype Switching by Human B Cells Is Division-Associated and Regulated by Cytokines1

S. Tangye, P. Hodgkin, D. Avery, 2002, The Journal of Immunology.

CXCR5 Expressing Human Central Memory CD4 T Cells and Their Relevance for Humoral Immune Responses

C. Mackay, S. Tangye, D. Jarrossay, 2011, The Journal of Immunology.

Identification of Functional Human Splenic Memory B Cells by Expression of CD148 and CD27

S. Tangye, J. Phillips, G. Aversa, 1998, The Journal of experimental medicine.

Chronic mucocutaneous candidiasis and connective tissue disorder in humans with impaired JNK1-dependent responses to IL-17A/F and TGF-β

J. Casanova, S. Boughorbel, S. Tangye, 2019, Science Immunology.

Chronic Aichi Virus Infection in a Patient with X-Linked Agammaglobulinemia

M. Van Ranst, S. Tangye, D. Mekahli, 2018, Journal of Clinical Immunology.

Human IL-23 is essential for IFN-γ-dependent immunity to mycobacteria

J. Casanova, S. Tangye, F. Sallusto, 2023, Science Immunology.

AD Hyper-IgE Syndrome Due to a Novel Loss-of-Function Mutation in STAT3: a Diagnostic Pursuit Won by Clinical Acuity

J. Casanova, S. Tangye, A. Voet, 2016, Journal of Clinical Immunology.

Decoding the Human Genetic and Immunological Basis of COVID-19 mRNA Vaccine-Induced Myocarditis

Mark S. Anderson, P. Gregersen, J. Casanova, 2022, Journal of Clinical Immunology.

Protein Tyrosine Phosphatase CD148-Mediated Inhibition of T-Cell Receptor Signal Transduction Is Associated with Reduced LAT and Phospholipase Cγ1 Phosphorylation

S. Tangye, R. Majeti, A. Weiss, 2001, Molecular and Cellular Biology.

Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets

J. Casanova, J. Ziegler, A. Bousfiha, 2016, The Journal of experimental medicine.

T follicular helper cells have distinct modes of migration and molecular signatures in naive and memory immune responses.

Imogen Moran, Tri Giang Phan, Warren Kaplan, 2015, Immunity.

The good, the bad and the ugly — TFH cells in human health and disease

S. Tangye, E. Deenick, R. Brink, 2013, Nature Reviews Immunology.

Cytokine-Mediated Regulation of Human B Cell Differentiation into Ig-Secreting Cells: Predominant Role of IL-21 Produced by CXCR5+ T Follicular Helper Cells1

Y. Li, S. Tangye, R. de Waal Malefyt, 2007, The Journal of Immunology.

The Role of BAFF and APRIL in Regulating Human B-Cell Behaviour: Implications for Disease Pathogenesis

S. Tangye, D. Fulcher, 2009 .

B Cells and Autoimmunity

S. Tangye, F. Mackay, 2006 .

BAFF selectively enhances the survival of plasmablasts generated from human memory B cells.

S. Tangye, P. Hodgkin, C. Ambrose, 2003, The Journal of clinical investigation.

SnapShot: Interactions between B Cells and T Cells

S. Tangye, T. Phan, C. Goodnow, 2015, Cell.

207: IL-27 signals to both B and T cells support germinal center function and the development of GC-driven lupus

S. Tangye, M. Batten, C. Vinuesa, 2013 .

STAT3 interrupts ATR-Chk1 signaling to allow oncovirus-mediated cell proliferation

S. Tangye, A. Freeman, Sumita Bhaduri-McIntosh, 2014, Proceedings of the National Academy of Sciences.

Immune cell transcriptome datasets reveal novel leukocyte subset-specific genes and genes associated with allergic processes.

Diego G. Silva, R. Xavier, C. Mackay, 2006, The Journal of allergy and clinical immunology.

Inherited human c-Rel deficiency disrupts myeloid and lymphoid immunity to multiple infectious agents.

J. Casanova, V. Lougaris, A. Plebani, 2021, The Journal of clinical investigation.

Unresponsiveness to inhaled antigen is governed by conventional dendritic cells and overridden during infection by monocytes

S. Tangye, Thi H. O. Nguyen, K. Kedzierska, 2020, Science Immunology.

Pathogenic CD4+ T cells regulating B‐cell differentiation in autoimmunity: not exactly Tfh cells

S. Tangye, 2017, Immunology and cell biology.

Ectopic B-helper CD 4 + T cells Pathogenic CD 4 + T cells regulating B-cell differentiation in autoimmunity : not exactly Tfh cells

S. Tangye, 2017 .

Coronavirus disease 2019 in patients with inborn errors of immunity: lessons learned

S. Tangye, I. Meyts, G. Bucciol, 2021, Current opinion in pediatrics.

STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function

J. Casanova, Joanne M. Smart, C. Picard, 2015, The Journal of experimental medicine.

STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological dysregulation of NKG2Dhi CD8 killer T cells

Timothy J. Peters, S. Mustjoki, S. Tangye, 2022, bioRxiv.

Evidence from the generation of immunoglobulin G–secreting cells that stochastic mechanisms regulate lymphocyte differentiation

S. Tangye, P. Hodgkin, D. Tarlinton, 2004, Nature Immunology.

Getting to the (germinal) center of humoral immune responses to SARS-CoV-2

S. Tangye, R. Bull, D. Burnett, 2022, Cell.

Arginine methylation catalyzed by PRMT1 is required for B cell activation and differentiation

S. Richard, S. Tangye, G. Belz, 2017, Nature Communications.

Comprehensive analysis of the cytokine-rich chromosome 5q31.1 region suggests a role for IL-4 gene variants in prostate cancer risk.

D. English, G. Giles, G. Severi, 2010, Carcinogenesis.

DOCK8 Drives Src-Dependent NK Cell Effector Function

J. Casanova, C. Picard, S. Tangye, 2017, The Journal of Immunology.

Immunologically Active Autoantigens : The Role of Toll-Like Receptors in the Development of Chronic Inflammatory Disease

S. Tangye, C. Rooney, K. Nichols, 2009 .

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

Andrew J. Oler, Eglantine Ferrand Devouge, P. Gregersen, 2023, Genome Medicine.

Emergence and antibody evasion of BQ, BA.2.75 and SARS-CoV-2 recombinant sub-lineages in the face of maturing antibody breadth at the population level

S. Tangye, D. Stark, A. Kelleher, 2023, eBioMedicine.

Genetic cause of immune dysregulation - one gene or two?

S. Tangye, 2016, The Journal of clinical investigation.

Human PIK3R1 mutations disrupt lymphocyte differentiation to cause activated PI3Kδ syndrome 2

David R. Croucher, David E. James, D. Croucher, 2023, The Journal of experimental medicine.

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

Andrew J. Oler, Eglantine Ferrand Devouge, P. Gregersen, 2023, Genome Medicine.

Low IgE Is Insufficiently Sensitive to Guide Genetic Testing of STAT3 Gain-of-Function Mutations.

S. Tangye, L. Forbes, J. Milner, 2017, Clinical chemistry.

STAT5B restrains human B-cell differentiation to maintain humoral immune homeostasis.

Timothy J. Peters, W. Al-Herz, S. Tangye, 2022, Journal of Allergy and Clinical Immunology.

Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency

J. Casanova, M. Nussenzweig, A. Sette, 2018, Nature Immunology.

Signal transducer and activator of transcription 3 (STAT3) mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8(+) T-cell memory formation and function.

J. Casanova, S. Choo, Joanne M. Smart, 2013, The Journal of allergy and clinical immunology.

Defi ciency of Th 17 cells in hyper IgE syndrome due to mutations in STAT 3 Cindy

S. Tangye, M. Cook, B. Grimbacher, 2008 .

Human CD8+ T cell cross-reactivity across influenza A, B and C viruses

David F. Boyd, S. Tangye, F. Luciani, 2019, Nature Immunology.

Correction to: Human Inborn Errors of Immunity: 2019 Update on the Classification from the International Union of Immunological Societies Expert Committee

J. Casanova, J. Franco, A. Bousfiha, 2020, Journal of Clinical Immunology.

The Clinical Immunogenomics Research Consortium Australasia (CIRCA): a Distributed Network Model for Genomic Healthcare Delivery

S. Tangye, T. Phan, M. Wong, 2020, Journal of Clinical Immunology.

STAT3 regulates cytotoxicity of human CD57+ CD4+ T cells in blood and lymphoid follicles

Susan M. Corley, M. Wilkins, S. Tangye, 2018, Scientific Reports.

Monogenic mutations differentially impact the quantity and quality of T follicular helper cells in human primary immunodeficiencies

Polina, Wong, Seyed, 2016 .

Elucidating the effects of disease-causing mutations on STAT3 function in autosomal-dominant hyper-IgE syndrome.

S. Tangye, E. Deenick, Simon J. Pelham, 2016, The Journal of allergy and clinical immunology.

DOCK8-Deficient CD4(+) T Cells are Biased to a Th2 Effector Fate at the Expense of Th1 and Th17 Cells.

J. Casanova, J. Orange, J. Ziegler, 2016 .

B-cell-specific STAT3 deficiency: Insight into the molecular basis of autosomal-dominant hyper-IgE syndrome.

S. Tangye, E. Deenick, R. Brink, 2016, The Journal of allergy and clinical immunology.

Inborn errors of human B cell development, differentiation, and function

S. Tangye, E. Deenick, Cindy S. Ma, 2023, The Journal of experimental medicine.

Molecular regulation and dysregulation of T follicular helper cells - learning from inborn errors of immunity.

S. Tangye, Cindy S. Ma, 2021, Current opinion in immunology.

Combined Immunodeficiency with Ring Chromosome 21

S. Tangye, Cindy S. Ma, A. Anazodo, 2018, Journal of Clinical Immunology.

Diversity of XMEN Disease: Description of 2 Novel Variants and Analysis of the Lymphocyte Phenotype

S. Tangye, G. Uzel, B. Wood, 2019, Journal of Clinical Immunology.

Autoantibodies Neutralizing Type I IFNs in the Bronchoalveolar Lavage of at Least 10% of Patients During Life-Threatening COVID-19 Pneumonia

J. Casanova, T. van der Poll, R. Lutter, 2023, Journal of Clinical Immunology.

Refractory very early-onset inflammatory bowel disease associated with cytosolic isoleucyl-tRNA synthetase deficiency: A case report

S. Tangye, W. Newman, P. Arkwright, 2020, World journal of gastroenterology.

Plasmacytoid DCs induce gutsy plasma cells.

S. Tangye, 2011, Immunity.

The Th17/IL-17 axis and host defence against fungal infections.

S. Tangye, A. Puel, 2023, The journal of allergy and clinical immunology. In practice.

Three Copies of Four Interferon Receptor Genes Underlie a Mild Type I Interferonopathy in Down Syndrome

D. Chaussabel, A. Munnich, J. Casanova, 2020, Journal of Clinical Immunology.

An essential role for the Zn2+ transporter ZIP7 in B cell development

J. Casanova, G. Rutter, M. van der Burg, 2019, Nature Immunology.

Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation.

S. Tangye, R. Majeti, A. Weiss, 2001, Molecular and cellular biology.

Respiratory viral infections in otherwise healthy humans with inherited IRF7 deficiency

Laura E. Covill, P. Gregersen, J. Casanova, 2022, The Journal of experimental medicine.

Reversible Suppression of Lymphoproliferation and Thrombocytopenia with Rapamycin in a Patient with Common Variable Immunodeficiency

S. Tangye, M. Cowley, T. Phan, 2018, Journal of Clinical Immunology.

Monogenic Early-Onset Lymphoproliferation and Autoimmunity: The Natural History of STAT3 GOF Syndrome.

K. Schwarz, M. Weinrich, F. Rieux-Laucat, 2022, The Journal of allergy and clinical immunology.

The TORC that Gets the GC Cycling.

S. Tangye, E. Deenick, 2017, Immunity.

Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria

Yi Hao Chan, L. Kremer, S. Tangye, 2023, Cell.

Isolated chronic mucocutaneous candidiasis due to a novel duplication variant of IL17RC

J. Casanova, S. Tangye, A. Puel, 2023, Research square.

Inflammatory Mechanisms in Obesity

S. Tangye, L. Sollid, P. Schwartzberg, 2013 .

Circulating precursor CCR7(lo)PD-1(hi) CXCR5⁺ CD4⁺ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure.

C. Mackay, S. Tangye, G. Belz, 2013, Immunity.

CXCR5 Expressing Human Central Memory CD4 T Cells and Their Relevance for Humoral Immune Responses

C. Mackay, S. Tangye, D. Jarrossay, 2011, The Journal of Immunology.

Disruption of an anti-mycobacterial circuit between dendritic and Th cells in human SPPL2a deficiency

Caroline, Tomi, A. Sette, 2018 .

Immune deficiencies , infection , and systemic immune disorders Clinical , molecular , and cellular immunologic findings in patients with SP 110-associated veno-occlusive disease with immunodeficiency syndrome

J. Ziegler, S. Tangye, J. Church, 2012 .

Reversible Suppression of Lymphoproliferation and Thrombocytopenia with Rapamycin in a Patient with Common Variable Immunodeficiency

S. Tangye, M. Cowley, T. Phan, 2018, Journal of Clinical Immunology.

Primary immune deficiencies affecting lymphocyte differentiation: lessons from the spectrum of resulting infections.

S. Tangye, M. Cook, 2009, International immunology.

The trajectory of human B‐cell function, immune deficiency, and allergy revealed by inborn errors of immunity

S. Tangye, Cindy S. Ma, Joseph Mackie, 2023, Immunological reviews.

Impaired Epstein-Barr virus-specific CD8+ T-cell function in X-linked lymphoproliferative disease is restricted to SLAM family-positive B-cell targets.

S. Tangye, P. Rohrlich, A. Rickinson, 2010, Blood.

Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency

J. Derisi, F. Rieux-Laucat, J. Fellay, 2023, Nature.

Expanded T cell clones with lymphoma driver somatic mutations in refractory celiac disease

S. Tangye, G. Ahlenstiel, R. Ciccocioppo, 2024, medRxiv.

The FOXP3Δ2 isoform supports Treg cell development and protects against severe IPEX syndrome.

S. Tangye, Cindy S. Ma, C. Verge, 2019, The Journal of allergy and clinical immunology.

Functional Consequences of Interactions between Human NKR-P1A and Its Ligand LLT1 Expressed on Activated Dendritic Cells and B Cells1

S. Tangye, L. Lanier, W. Cao, 2008, The Journal of Immunology.

The ups and downs of STAT3 function: too much, too little and human immune dysregulation.

S. Tangye, Cindy S. Ma, A. Guérin, 2023, Clinical and experimental immunology.

FAS Inactivation Releases Unconventional Germinal Center B Cells that Escape Antigen Control and Drive IgE and Autoantibody Production.

A. Strasser, S. Tangye, T. Phan, 2015, Immunity.

Role of IL-27 in Epstein-Barr virus infection revealed by IL-27RA deficiency.

S. Tangye, A. Puel, D. Boutboul, 2024, Nature.