J. Trosko

发表

J. Trosko, Chia‐cheng Chang, 1978 .

Challenge to the simple paradigm that 'carcinogens' are 'mutagens' and to the in vitro and in vivo assays used to test the paradigm.

J. Trosko, J E Trosko, 1997, Mutation research.

Ozonation of chrysene: evaluation of byproduct mixtures and identification of toxic constituent.

J. Trosko, S. Masten, S. Luster-Teasley, 2002, Environmental science & technology.

What Can Chemical Carcinogenesis Shed Light on the LNT Hypothesis in Radiation Carcinogenesis?

J. Trosko, 2019, Dose-response : a publication of International Hormesis Society.

Platinum Compounds: a New Class of Potent Antitumour Agents

J. Trosko, BARNETT ROSENBERG, B. Rosenberg, 1969, Nature.

Stem cells in toxicology: fundamental biology and practical considerations.

Kyung-Sun Kang, J. Trosko, K. Kang, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

Prevention of the down-regulation of gap junctional intercellular communication by green tea in the liver of mice fed pentachlorophenol.

J. Trosko, J. Kanno, R. Hasegawa, 2000, Carcinogenesis.

The causes of cancer: Implications for prevention and treatment

J. Trosko, B. Madhukar, 1997, Indian journal of pediatrics.

Oxidative stress in liver and brain of the hatchling chicken (Gallus domesticus) following in ovo injection with TCDD.

J. Trosko, J. Giesy, K. Hilscherová, 2003, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

Characteristics of long-term human epithelial cell cultures derived from normal human fetal kidney

J. Trosko, C. Chang, S. D'Ambrosio, 1987, In Vitro Cellular & Developmental Biology.

Scrape-loading and dye transfer. A rapid and simple technique to study gap junctional intercellular communication.

J. Trosko, Chia‐cheng Chang, C. Chang, 1987, Experimental cell research.

Chemopreventive Agents Attenuate Rapid Inhibition of Gap Junctional Intercellular Communication Induced by Environmental Toxicants

J. Trosko, P. Babica, Lucie Čtveráčková, 2016, Nutrition and cancer.

Phosphatidylcholine Specific PLC-Induced Dysregulation of Gap Junctions, a Robust Cellular Response to Environmental Toxicants, and Prevention by Resveratrol in a Rat Liver Cell Model

J. Trosko, P. Babica, I. Sovadinová, 2015, PloS one.

Phosphatidylcholine Specific PLC-Induced Dysregulation of Gap Junctions, a Robust Cellular Response to Environmental Toxicants, and Prevention by Resveratrol in a Rat Liver Cell Model.

J. Trosko, P. Babica, I. Sovadinová, 2015 .

Tumor promoting properties of a cigarette smoke prevalent polycyclic aromatic hydrocarbon as indicated by the inhibition of gap junctional intercellular communication via phosphatidylcholine‐specific phospholipase C

J. Trosko, J. Vondráček, M. Machala, 2008, Cancer science.

Inhibition of Gap Junctional Intercellular Communication and Activation of Mitogen-Activated Protein Kinase by Tumor-Promoting Organic Peroxides and Protection by Resveratrol

J. Trosko, J. Carbone, L. Bláha, 2007, Nutrition and cancer.

MX, a by‐product of water chlorination, lacks in vivo genotoxicity in gpt delta mice but inhibits gap junctional intercellular communication in rat WB cells

J. Trosko, H. Son, K. Kanki, 2006, Environmental and molecular mutagenesis.

Effect of byproducts from the ozonation of pyrene: Biphenyl‐2,2′,6,6′‐tetracarbaldehyde and biphenyl‐2,2′,6,6′‐tetracarboxylic acid on gap junction intercellular communication and neutrophil function

Joseph S. Ward, J. Trosko, P. Ganey, 2005, Environmental toxicology and chemistry.

Concentration/response effect of 2,2′, 4,4′, 5,5′-hexabromobiphenyl on cell-cell communication in vitro: assessment by fluorescence redistribution after photobleaching (“FRAP”)

J. Trosko, M. Evans, 1988, Cell Biology and Toxicology.

Cannabinoids inhibit gap junctional intercellular communication and activate ERK in a rat liver epithelial cell line

J. Trosko, J. Carbone, N. Kaminski, 2003, International journal of cancer.

Regulation of cell‐to‐cell communication in non‐tumorigenic and malignant human prostate epithelial cells

M. Webber, J. Trosko, G. Carruba, 2002, The Prostate.

Effect of selected pesticides and their ozonation by-products on gap junctional intercellular communication using rat liver epithelial cell lines.

J. Trosko, S. Masten, B. Upham, 2001, Chemosphere.

Inhibition of apoptosis by pentachlorophenol in v-myc-transfected rat liver epithelial cells: relation to down-regulation of gap junctional intercellular communication.

J. Trosko, A. Hirose, R. Hasegawa, 2001, Cancer letters.

λ-Carrageenan-Induced Inhibition of Gap-Junctional Intercellular Communication in Rat Liver Epithelial Cells

J. Trosko, Chia‐cheng Chang, H. Na, 2000 .

Gap junctions and the regulation of cellular functions of stem cells during development and differentiation.

J. Trosko, C. Chang, M. Wade, 2000, Methods.

Preventive effect of epicatechin and ginsenoside Rb(2) on the inhibition of gap junctional intercellular communication by TPA and H(2)O(2).

J. Trosko, B. Lee, K. Kang, 2000, Cancer letters.

Restoration of gap junctional intercellular communication by caffeic acid phenethyl ester (CAPE) in a ras-transformed rat liver epithelial cell line.

J. Trosko, Chia‐cheng Chang, H. Na, 2000, Cancer letters.

Inhibitory effect of pentachlorophenol on gap junctional intercellular communication in rat liver epithelial cells in vitro.

J. Trosko, R. Hasegawa, K. Sai, 1998, Cancer letters.

Restored gap junctional communication in non-tumorigenic HeLa-normal human fibroblast hybrids.

J. Trosko, E. Stanbridge, J. Redpath, 1998, Carcinogenesis.

Hydrogen peroxide inhibits gap junctional intercellular communication in glutathione sufficient but not glutathione deficient cells.

J. Trosko, H. Cho, B. Upham, 1997, Carcinogenesis.

Non-Genotoxic Effects of Selected Pesticides and Their Disinfection By-Products on Gap Junctional Intercellular Communication

J. Trosko, S. Masten, B. Upham, 1997 .

The effects of anthracene and methylated anthracenes on gap junctional intercellular communication in rat liver epithelial cells.

J. Trosko, S. Masten, B. Upham, 1996, Fundamental and applied toxicology : official journal of the Society of Toxicology.

Pulse treatment with the tumor promoter TPA delays the onset of desensitization response and prolongs the inhibitory effect on gap junctional intercellular communication of a rat liver epithelial cell line WB F-344.

J. Trosko, B. Madhukar, H. De Feijter-Rupp, 1996, Cancer letters.

Inhibition of gap junctional intercellular communication in normal human breast epithelial cells after treatment with pesticides, PCBs, and PBBs, alone or in mixtures.

J. Trosko, Chia‐cheng Chang, C. Chang, 1996, Environmental health perspectives.

Reversal of ras‐induced inhibition of gap‐junctional intercellular communication, transformation, and tumorigenesis by lovastatin

J. Trosko, B. Madhukar, J. Klaunig, 1993, Molecular carcinogenesis.

Restoration of gap‐junctional intercellular communication in a communication‐deficient rat liver cell mutant by transfection with connexin 43 cDNA

J. Trosko, Chia‐cheng Chang, Y. Jou, 1993, Molecular carcinogenesis.

Homologous and heterologous Gap‐junctional intercellular communication in v‐raf‐, v‐myc‐, and v‐raf/v‐myc‐transduced rat liver epithelial cell lines

S. Thorgeirsson, J. Trosko, A. Huggett, 1992, Molecular carcinogenesis.

The Modulation of Gap Junctional Communication by Gossypol in Various Mammalian Cell Lines in vitro

T. Akera, J. Trosko, Chia‐cheng Chang, 1990 .

TPA-induced inhibition of gap junctional intercellular communication is not mediated through free radicals.

J. Trosko, C. Hasler, M. Frick, 1990, Toxicology and applied pharmacology.

Anchored cell analysis/sorting coupled with the scrape-loading/dye-transfer technique to quantify inhibition of gap-junctional intercellular communication in WB-F344 cells by 2,2',4,4',5,5'-hexabromobiphenyl.

J. Trosko, M. H. El-Fouly, M. Evans, 1988, Journal of toxicology and environmental health.

Cytoskeletal and junctional heterogeneity in mammary tumor cells and their possible significance in tumor progression.

J. Trosko, G. Nicolson, R. Lichtner, 1988, Advances in experimental medicine and biology.

Saccharin may act as a tumour promoter by inhibiting metabolic cooperation between cells

J. Trosko, Chia‐cheng Chang, C. Chang, 1980, Nature.

The role of inhibited cell-cell communication in teratogenesis.

J. Trosko, Chia‐cheng Chang, C. Chang, 1982, Teratogenesis, carcinogenesis, and mutagenesis.

Further characterization of the in vitro assay for inhibitors of metabolic cooperation in the Chinese hamster V79 cell line.

J. Trosko, C. Chang, C. Jone, 1985, Carcinogenesis.

hESC Technology for Toxicology and Drug Development: Summary of Current Status and Recommendations for Best Practice and Standardization The Report and Recommendations of and ECVAM Workshop.

J. Trosko, T. Hartung, C. Mandenius, 2007 .

Adult Stem Cells, the Barker Hypothesis, Epigenetic Events, and Low-Level Radiation Effects

J. Trosko, Keiji Suzuki, 2009 .

Preferential cytotoxicity of cells transduced with cytosine deaminase compared to bystander cells after treatment with 5-flucytosine.

J. Trosko, A. Rehemtulla, T. Lawrence, 1998, Cancer research.

Effect of biological toxins on gap-junctionai intercellular communication in Chinese hamster V79 cells

J. Trosko, Chia‐cheng Chang, C. Jone, 1987, Cell Biology and Toxicology.

Interruption of cell-cell communication in Chinese hamster V79 cells by various alkyl glycol ethers: implications for teratogenicity.

J. Trosko, R. Loch-Caruso, I. Corcos, 1984, Environmental health perspectives.

Stimulation of cell proliferation and inhibition of gap junctional intercellular communication by linoleic acid.

J. Trosko, D. Matesic, C. Chang, 1997, Cancer letters.

Isolation and characterization of normal adult human epithelial pluripotent stem cells.

J. Trosko, Chia‐cheng Chang, 2003, Oncology research.

The gap junction as a “Biological Rosetta Stone”: implications of evolution, stem cells to homeostatic regulation of health and disease in the Barker hypothesis

J. Trosko, James E. Trosko, 2011, Journal of Cell Communication and Signaling.

The role of stem cells and cell–cell communication in radiation carcinogenesis: ignored concepts

J. Trosko, 2005 .

Human stem cells as targets for the aging and diseases of aging processes.

J. Trosko, 2003, Medical Hypotheses.

Hallmarks of radiation carcinogenesis: ignored concepts

J. Trosko, Chia‐cheng Chang, 2003 .

The role of stem cells and gap junctional intercellular communication in carcinogenesis.

J. Trosko, 2003, Journal of biochemistry and molecular biology.

Role of Stem Cells and Gap Junctional Intercellular Communication in Human Carcinogenesis

J. Trosko, Chia‐cheng Chang, C. Chang, 2001, Radiation research.

Inhibition of connexin43 gap junctional intercellular communication by TPA requires ERK activation

J. Trosko, B. Madhukar, R. Ruch, 2001, Journal of cellular biochemistry.

Loss of intercellular junctional communication correlates with metastatic potential in mammary adenocarcinoma cells.

J. Trosko, G. Nicolson, K. Dulski, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Ready to go 3D? A semi-automated protocol for microwell spheroid arrays to increase scalability and throughput of 3D cell culture testing

J. Trosko, P. Babica, L. Bláha, 2020, Toxicology mechanisms and methods.

Promotion of 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis by high dietary fat in the rat: possible role of intercellular communication.

J. Trosko, J. Meites, C. Jone, 1984, Journal of the National Cancer Institute.

A Paradigm Shift is Required for the Risk Assessment of Potential Human Health After Exposure to Low Level Chemical Exposures

J. Trosko, B. Upham, 2010, International journal of toxicology.

Protection of herpes simplex virus thymidine kinase-transduced cells from ganciclovir-mediated cytotoxicity by bystander cells: the Good Samaritan effect.

J. Trosko, A. Rehemtulla, T. Lawrence, 1997, Cancer research.

Oncogenes, inhibited intercellular communication and tumor promotion.

J. Trosko, C. Chang, C. Jone, 1983, Princess Takamatsu symposia.

Neoplastic phenotype of gap‐junctional intercellular communication–deficient WB rat liver epithelial cells and its reversal by forced expression of connexin 32

J. Trosko, Chia‐cheng Chang, P. Mehta, 1998, Molecular carcinogenesis.

From adult stem cells to cancer stem cells: Oct-4 Gene, cell-cell communication, and hormones during tumor promotion.

J. Trosko, 2006, Annals of the New York Academy of Sciences.

A comparison of the propensity for gene amplification between near-tetraploid and near-diploid V79 clones resistant to 150 nM methotrexate.

J. Trosko, O. Nikaido, C. Chang, 1996, Carcinogenesis.

Expression of estrogen receptors in a normal human breast epithelial cell type with luminal and stem cell characteristics and its neoplastically transformed cell lines.

J. Trosko, I. Morita, C. Chang, 1997, Carcinogenesis.

Evolution of energy metabolism, stem cells and cancer stem cells: how the warburg and barker hypotheses might be linked.

J. Trosko, K. Kang, 2012, International journal of stem cells.

Cell-Cell Communication as Fundamental Targets in Assessing the Potential Toxicity of Chemicals Commentary on ' ' Toxicity Testing in the 21 st Century : A vision and a Strategy ' ' : Stem Cells and

J. Trosko, 2010 .

Modulation by aspirin and naproxen of nucleotide alterations and tumors in the lung of mice exposed to environmental cigarette smoke since birth.

S. De Flora, R. Balansky, F. D'Agostini, 2015, Carcinogenesis.

Structure-Activity–Dependent Regulation of Cell Communication by Perfluorinated Fatty Acids using in Vivo and in Vitro Model Systems

J. Trosko, J. Kanno, P. Babica, 2008, Environmental health perspectives.

Concentrations of methylated naphthalenes, anthracenes, and phenanthrenes occurring in Czech river sediments and their effects on toxic events associated with carcinogenesis in rat liver cell lines

J. Trosko, A. Kozubík, J. Vondráček, 2007, Environmental toxicology and chemistry.

Localization and function of the connexin 43 gap‐junction protein in normal and various oncogene‐expressing rat liver epithelial cells

J. Trosko, Chia‐cheng Chang, D. Matesic, 1996, Molecular carcinogenesis.

Potential role of the src gene product in inhibition of gap-junctional communication in NIH/3T3 cells.

J. Trosko, Chia‐cheng Chang, H. Kung, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Inhibition of gap junctional blockage by palmitoyl carnitine and TMB-8 in a rat liver epithelial cell line.

J. Trosko, B. Madhukar, S. Y. Oh, 1988, Carcinogenesis.

Inhibition of gap junctional intercellular communication in heptachlor- and heptachlor epoxide-treated normal human breast epithelial cells

J. Trosko, D. Matesic, C. Chang, 1996, Cell Biology and Toxicology.

Redox-Mediated Enrichment of Self-Renewing Adult Human Pancreatic Cells That Possess Endocrine Differentiation Potential

L. Olson, J. Trosko, B. Madhukar, 2004, Pancreas.

Gap junctions as targets for cancer chemoprevention and chemotherapy.

J. Trosko, R. Ruch, 2002, Current drug targets.

Role of diet and nutrition on the alteration of the quality and quantity of stem cells in human aging and the diseases of aging.

J. Trosko, 2008, Current pharmaceutical design.

Cockayne syndrome: a cellular sensitivity to ultraviolet light.

J. Trosko, R. Schmickel, C. C. Chang, 1977, Pediatrics.

Modulators of gap junction function: the scientific basis of epigenetic toxicology

J. Trosko, B. Madhukar, C. Chang, 1990 .

Ultraviolet light induction of diphtheria toxin-resistant mutants of normal and xeroderma pigmentosum human fibroblasts.

J. Trosko, Chia‐cheng Chang, T. Glover, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Stem Cells and Cell-Cell Communication in the Understanding of the Role of Diet and Nutrients in Human Diseases

J. Trosko, 2007 .

Divergent roles for glutathione in lindane-induced acute and delayed-onset inhibition of rat myometrial gap junctions.

J. Trosko, R. Loch-Caruso, C. Harris, 2005, Toxicological sciences : an official journal of the Society of Toxicology.

Plasmid-aided insertion of MMTV-LTR and ras DNAs to NIH 3T3 fibroblast cells makes them responsive to 2,3,7,8-TCDD causing overexpression of p21ras and down-regulation of EGF receptor.

J. Trosko, A. Pellicer, F. Matsumura, 1989, Molecular toxicology.

TOXICOLOGICAL HIGHLIGHT Intercellular Communication, Homeostasis, and Toxicology

J. Trosko, C. Lau, Wenyue Hu, 2002 .

Comparative Study of X-Ray and UV Induced Cytotoxicity, DNA Repair, and Mutagenesis in Down's Syndrome and Normal Fibroblasts

J. Trosko, T. Glover, D. Segal, 1980, Pediatric Research.

Inhibition of Gap Junctional Intercellular Communication Upregulates Pluripotency Gene Expression in Endogenous Pluripotent Muse Cells

J. Trosko, M. Dezawa, S. Wakao, 2022, Cells.

Non-dioxin-like polychlorinated biphenyls induce a release of arachidonic acid in liver epithelial cells: a partial role of cytosolic phospholipase A(2) and extracellular signal-regulated kinases 1/2 signalling.

J. Trosko, A. Kozubík, Z. Andrysik, 2008, Toxicology.

Mammalian mutator mutant with an aphidicolin-resistant DNA polymerase alpha.

L. Loeb, J. Trosko, G. Martin, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Assessment of Hepatotoxic Potential of Cyanobacterial Toxins Using 3D In Vitro Model of Adult Human Liver Stem Cells.

J. Trosko, P. Babica, L. Bláha, 2018, Environmental science & technology.

Inhibition of metabolic coupling by metals.

J. Trosko, R. Loch-Caruso, I. Corcos, 1991, Journal of toxicology and environmental health.

In situ (6-4)photoproduct determination by laser cytometry and autoradiography.

J. Trosko, T. Matsunaga, T. Mori, 1990, Mutation research.

Repair of UV-induced pyrimidine dimers in Drosophila melanogaster cells in vitro.

J. Trosko, K. Wilder, 1973, Genetics.

Effect of caffeine on the induction of mutations in Chinese hamster cells by ultraviolet light.

J. Trosko, E. Chu, J. Morrow, 1971, Mutation research.

Hexamethylene bisacetamide protects peritoneal mesothelial cells from glucose.

N. Yorioka, J. Trosko, S. Kyoizumi, 2001, Kidney international.

Role of intercellular communication in modifying the consequences of mutations in somatic cells.

J. Trosko, C. Chang, C. Chang, 1986, Basic life sciences.

Failure to induce mutations in Chinese hamster V79 cells and WB rat liver cells by the polybrominated biphenyls, Firemaster BP-6, 2,2',4,4',5,5'-hexabromobiphenyl, 3,3',4,4',5,5'-hexabromobiphenyl, and 3,3',4,4'-tetrabromobiphenyl.

J. Trosko, T. Kavanagh, S. Sleight, 1985, Toxicology and applied pharmacology.

Suppression of gap-junction gene expression by growth factors and TPA in human epidermal keratinocytes in vitro

J. Trosko, B. Madhukar, E. Dupont, 1993 .

Biphasic lindane-induced oxidation of glutathione and inhibition of gap junctions in myometrial cells.

J. Trosko, C. Harris, B. Upham, 2005, Toxicological sciences : an official journal of the Society of Toxicology.

Decreased incidence of gap junctions between Chinese hamster V-79 cells upon exposure to the tumor promoter 12-O-tetradecanoyl phorbol-13-acetate.

J. Trosko, J. Revel, S. Yancey, 1982, Experimental cell research.

5-Flucytosine Deaminase Compared to Bystander Cells after Treatment with Preferential Cytotoxicity of Cells Transduced with Cytosine Updated

J. Trosko, P. Stetson, Théodore, 2006 .

Suberoylanilide hydroxamic acid enhances gap junctional intercellular communication via acetylation of histone containing connexin 43 gene locus.

N. Yorioka, J. Trosko, Chia‐cheng Chang, 2005, Cancer research.

Effects of fatty acids on gap junctional communication: Possible role in tumor promotion by dietary fat

J. Trosko, C. Welsch, C. Aylsworth, 1987, Lipids.

CHAPTER 7 – Potential Role of Calmodulin in Tumor Promotion: Modulator of Gap Junctional Intercellular Communication*,†

J. Trosko, Chia‐cheng Chang, C. Jone, 1985 .

Possible Involvement of Arachidonate Products in Tumor Promoter Inhibition of Cell-Cell Communication

J. Trosko, C. Jone, C. Aylsworth, 1985 .

Infection of rat liver epithelial cells with v‐Ha‐ras: Correlation between oncogene expression, gap junctional communication, and tumorigenicity

J. Trosko, Chia‐cheng Chang, C. Weghorst, 1990, Molecular carcinogenesis.

Altered regulation of intercellular communication by epidermal growth factor, transforming growth factor-beta and peptide hormones in normal human keratinocytes.

J. Trosko, B. Madhukar, M. Wade, 1989, Carcinogenesis.

Phorbol ester-associated changes in ganglioside metabolism.

J. Trosko, C. Sweeley, J. Moskal, 1983, Experimental cell research.

Differential roles of 2, 6, and 8 carbon ceramides on the modulation of gap junctional communication and apoptosis during carcinogenesis.

J. Trosko, A. Horvath, B. Upham, 2003, Cancer letters.

Membrane Channel Connexin 32 Maintains Lin−/c-kit+ Hematopoietic Progenitor Cell Compartment: Analysis of the Cell Cycle

J. Trosko, J. Kanno, Y. Hirabayashi, 2007, Journal of Membrane Biology.

Protective Role of Connexin 32 in Steady-State Hematopoiesis, Regeneration State, and Leukemogenesis

J. Trosko, J. Kanno, Y. Hirabayashi, 2007, Experimental biology and medicine.

Effect of a tobacco-related nitrosamine on intercellular communication in human urothelial cells: a possible factor in smoking-related bladder carcinogenesis.

J. Trosko, C. Mothersill, C. Seymour, 1996, Oncology Research.

Characterization of gap junctional communication-deficient mutants of a rat liver epithelial cell line.

J. Trosko, B. Madhukar, J. Briand, 1993, European journal of cell biology.

SKIN TUMOR-PROMOTING ACTIVITY OF BENZOYL PEROXIDE, A WIDELY USED FREE RADICAL-GENERATING COMPOUND

L. Triplett, T. Slaga, J. Trosko, 1982 .

Reduced gap junctional intercellular communication and altered biological effects in mouse osteoblast and rat liver oval cell lines transfected with dominant‐negative connexin 43

J. Trosko, Chia‐cheng Chang, V. Krutovskikh, 2003, Molecular carcinogenesis.

Inhibition of intercellular communication by chlordecone (kepone) and mirex in Chinese hamster v79 cells in vitro.

J. Trosko, F. Matsumura, G. Tsushimoto, 1982, Toxicology and applied pharmacology.

The epigenetic toxicity of pyrene and related ozonation byproducts containing an aldehyde functional group.

J. Trosko, S. Masten, H. A. Herner, 2001, Environmental science & technology.

Influence of lipids on gap-junction-mediated intercellular communication between Chinese hamster cells in vitro.

J. Trosko, C. Welsch, C. Aylsworth, 1986, Cancer research.

Inhibition of cell-cell communication by tumor promoters.

S. Warren, J. Trosko, L. Yotti, 1982, Carcinogenesis; a comprehensive survey.

In vivo reversal of thyroxine induction of DNA synthesis by dibutyryl cyclic AMP in developing rat cerebellum

J. Trosko, M. Weichsel, 1976, Journal of the Neurological Sciences.

Studies on the mechanism of inhibition of 2-acetylaminofluorene toxicity by butylated hydroxytoluene.

J. Trosko, J. Yager, J. Goodman, 1976, Chemico-biological interactions.

Bioethics: a philosophical basis for moral decisions.

J. Trosko, 2001, Taiwan yi xue ren wen xue kan.

Correlation of increased levels of Ha‐ras T24 protein with extent of loss of gap junction function in rat liver epithelial cells

J. Trosko, D. Krizman, M. Lieberman, 1992, Molecular carcinogenesis.

Association of mutator activity with UV sensitivity in an aphidicolin-resistant mutant of Chinese hamster V79 cells.

J. Trosko, P. Liu, C. Chang, 1982, Mutation research.

Gene expression analysis in SV40-immortalized human breast luminal epithelial cells with stem cell characteristics using a cDNA microarray.

D. Noh, J. Trosko, Chia‐cheng Chang, 2004, International journal of oncology.

Intercellular communication may facilitate apoptosis: Implications for tumor promotion

J. Trosko, J. Goodman, 1994, Molecular carcinogenesis.

Modulation of cell-cell communication in the cause and chemoprevention/chemotherapy of cancer.

J. Trosko, C. Chang, C. Chang, 2000, BioFactors.

Comments on "What is a tumor promoter?".

J. Trosko, 1999, Environmental Health Perspectives.

Incorporation of n−3 fatty acids into WB-F344 cell phospholipids inhibits gap junctional intercellular communication

J. Trosko, C. Hasler, M. Bennink, 1991, Lipids.

Inhibition of gap junctional intercellular communication by perfluorinated fatty acids is dependent on the chain length of the fluorinated tail

J. Trosko, J E Trosko, B. Upham, 1998, International journal of cancer.

Scientific Concepts of Human Nature and Their Implications to Bioethics in a Scientific and Technologically-Altered World

J. Trosko, 2001 .

Inhibition of metabolic cooperation by the anticonvulsants, diphenylhydantoin and phenobarbital.

J. Trosko, Chia‐cheng Chang, C. Jone, 1985, Teratogenesis, carcinogenesis, and mutagenesis.

Modulated gap junctional intercellular communication as a biomarker of PAH epigenetic toxicity: structure-function relationship.

J. Trosko, B. Upham, L. M. Weis, 1998, Environmental health perspectives.

Cell-cell communication in carcinogenesis.

J. Trosko, R J Ruch, J E Trosko, 1998, Frontiers in bioscience : a journal and virtual library.

Mechanisms of tumor promotion: potential role of intercellular communication.

J. Trosko, C. Chang, A. Medcalf, 1983, Cancer investigation.

Inhibition of metabolic cooperation in Chinese hamster V79 cells in culture by various polybrominated biphenyl (PBB) congeners.

J. Trosko, S. Aust, G. Tsushimoto, 1982, Carcinogenesis.

Inhibition of intercellular communication in cultures of Chinese hamster V79 cells by 2,4-dichlorophenoxyacetic acid and 2,4,5-trichlorophenoxyacetic acid.

J. Trosko, Chia‐cheng Chang, C. Jone, 1984, Fundamental and applied toxicology : official journal of the Society of Toxicology.

A sensitive method to measure physical and chemical carcinogen-induced "unscheduled DNA synthesis" in rapidly dividing eukaryotic cells.

J. Trosko, J. Yager, 1974, Experimental cell research.

Evidence for excision of ultraviolet-induced pyrimidine dimers from the DNA of human cells in vitro.

J. Trosko, W. Carrier, J. Regan, 1968, Biophysical journal.

Cellsced Endoreduplication in Chinese Hamster

J. Trosko, Chia‐cheng Chang, Yuquan Huang, 2013 .

Effects of harman and norharman on spontaneous and ultraviolet light-induced mutagenesis in cultured Chinese hamster cells.

J. Trosko, T. Glover, M. Castellazzi, 1978, Cancer research.

Oct4 expression in adult human stem cells: evidence in support of the stem cell theory of carcinogenesis.

L. Olson, J. Trosko, Chia‐cheng Chang, 2004, Carcinogenesis.

Use and application of stem cells in toxicology.

Toshio Miki, J. Trosko, S. Strom, 2004, Toxicological sciences : an official journal of the Society of Toxicology.

The role of DNA repair and somatic mutation in carcinogenesis.

J. Trosko, E. Chu, 1975, Advances in cancer research.

Response of tobacco and Haplopappus cells to ultraviolet irradiation after posttreatment with photoreactivating light.

J. Trosko, V. H. Mansour, 1968, Radiation research.

Inhibition of ultraviolet-induced chromosome breaks by cysteamine in 5-bromouracil-substituted mammalian cells.

J. G. Brewen, J. Trosko, J. Brewen, 1967, Radiation research.

Endogenous and exogenous modulation of gap junctional intercellular communication: toxicological and pharmacological implications.

J. Trosko, B. Madhukar, J E Trosko, 1993, Life sciences.

Effect of phorbol myristate acetate on the recovery of spontaneous and ultraviolet light-induced 6-thioguanine and ouabain-resistant Chinese hamster cells.

J. Trosko, L. Yotti, E. Chu, 1977, Cancer research.

The Role of Radiation and Chemicals in the Induction of Mutations and Epigenetic Changes during Carcinogenesis1

J. Trosko, Chia‐cheng Chang, 1981 .

Methylene blue dye test for rapid qualitative detection of hydroxyl radicals formed in a Fenton's reaction aqueous solution.

J. Trosko, S. Masten, James E Trosko, 2007, Environmental science & technology.

Effect of Retinole Acid and Phorbol-12-myristate-13-acetate on Glycosyltransferase Activities in Normal and Transformed Cells1

C. C. Marvel, J. Trosko, C. Sweeley, 2006 .

Effect of retinoic acid and phorbol-12-myristate-13-acetate on glycosyltransferase activities in normal and transformed cells.

C. C. Marvel, J. Trosko, C. Sweeley, 1987, Cancer research.

Elimination of metabolic cooperation in Chinese hamster cells by a tumor promoter.

J. Trosko, L. Yotti, C. Chang, 1979, Science.

In vitro Assay for Tumor Promoters

J. Trosko, Chia‐cheng Chang, B. Dawson, 1981 .

Effect of temperature and exogenous dibutyryl c-AMP on the recovery of UV-induced ouabain-resistant Chinese hamster cells.

J. Trosko, M. Castellazzi, C. Chang, 1981, Mutation research.

Genes, pollutants and human diseases

J. Trosko, C. Chang, 1978, Quarterly Reviews of Biophysics.

CHEMICAL MODIFICATION OF RADIATION-INDUCED MUTAGENESIS AND ITS ROLE IN CARCINOGENESIS

J. Trosko, Chia‐cheng Chang, 1978 .

The effects of several croton oil constituents on two types of DNA repair and cyclic nucleotide levels in mammalian cells in vitro.

J. Trosko, J. Yager, G. T. Bowden, 1975, Chemico-biological interactions.

THE INDUCTION OF THYMINE DIMERS IN ULTRAVIOLET-IRRADIATED MAMMALIAN CELLS.

J. Trosko, W. Carrier, E. Chu, 1965, Radiation research.

RELATIONSHIP BETWEEN MUTAGENESIS AND CARCINOGENESIS *

J. Trosko, Chia‐cheng Chang, 1978, Photochemistry and photobiology.

The Role of Mutagenesis in Carcinogenesis

J. Trosko, Chia‐cheng Chang, 1978 .

Mutational approaches to the study of carcinogenesis.

J. Trosko, E. Chu, C. Chang, 1977, Journal of toxicology and environmental health.

Role of DNA Repair in Mutation and Cancer Production

J. Trosko, Chia‐cheng Chang, 1976 .

DNA Mutation Frequencies in Mammals

J. Trosko, R. Hart, 1976 .

DNA Repair Processes in Mammals

J. Trosko, R. Hart, 1976 .

Inhibition of repair of UV-damaged DNA by caffeine and mutation induction in Chinese hamster cells.

J. Trosko, E. Chu, James E. Trosko, 1973, Chemico-biological interactions.

Caffeine inhibition of postreplication repair of N-acetoxy-2-acetylamino fluorene-damaged DNA in Chinese hamster cells.

J. Trosko, E. Chu, J. Becker, 1973, Cancer research.

DNA-degradation products from mammalian cells irradiated with ultra-violet light.

J. Trosko, J. Cleaver, 1969, International journal of radiation biology and related studies in physics, chemistry, and medicine.

Aphidicolin-induced endoreduplication in Chinese hamster cells.

J. Trosko, C. Chang, Y. Huang, 1983, Cancer research.

Communication Aphidicolin-induced Endoreduplication in Chinese Hamster Cells1

J. Trosko, Chia‐cheng Chang, Yuquan Huang, 1983 .

The relation between 5-amino uracil-induced mitotic synchronization and DNA synthesis.

J. Trosko, K. Jakob, 1965, Experimental cell research.

Characterization of ultraviolet light-induced ouabain-resistant mutations in Chinese hamster cells.

T. Akera, J. Trosko, C. Chang, 1978, Mutation research.

Psyllium extracts decreased neoplastic phenotypes induced by the Ha-Ras oncogene transfected into a rat liver oval cell line.

J. Trosko, Chia‐cheng Chang, Yasushi Nakamura, 2004, Cancer letters.

Photosensitizing effect of trisoralen on DNA synthesis in human cells grown in vitro.

J. Trosko, M. Isoun, 1971, International journal of radiation biology and related studies in physics, chemistry, and medicine.

Lack of photoreactivation in human cells grown in vitro.

J. Trosko, M. Isoun, 1970, International journal of radiation biology and related studies in physics, chemistry, and medicine.

STUDY OF PYRIMIDINE DIMERS IN MAMMALIAN CELLS SURVIVING LOW DOSES OF ULTRAVIOLET RADIATION *

J. Trosko, M. R. Kasschau, James E. Trosko, 1967 .

Selection of aphidicolin-resistant CHO cells with altered levels of ribonucleotide reductase

J. Trosko, Chia‐cheng Chang, C. Sabourin, 1982, Somatic cell genetics.

Mutagenic and epigenetic influence of caffeine on the frequencies of UV-induced ouabain-resistant Chinese hamster cells.

J. Trosko, R. Hart, C. Philipps, 1977, Mutation research.

ABSENCE OF EXCISION OF ULTRAVIOLET‐INDUCED CYCLOBUTANE DIMERS IN XERODERMA PIGMENTOSUM *

J. Trosko, J. Cleaver, J. E. TROSKO, 1970, Photochemistry and photobiology.

Excision of pyrimidine dimers from epidermal DNA and nonsemiconservative epidermal DNA synthesis following ultraviolet irradiation of mouse skin.

J. Trosko, G. T. Bowden, R. Boutwell, 1975, Cancer research.

Excision repair (dimer excision, strand breakage and repair replication) in primary cultures of eukaryotic (bovine) cells.

J. Trosko, J. Lett, J. Cleaver, 1972, Experimental cell research.

Enhanced survival and decreased mutation frequency after photoreactivation of UV damage in rat kangaroo cells.

J. Trosko, M. Wade, 1983, Mutation research.

Ultraviolet light induction of diphtheria toxin-resistant mutations in normal and DNA repair-deficient human and Chinese hamster fibroblasts.

J. Trosko, T. Glover, C. Chang, 1980, Basic life sciences.

Sunlight-induced Pyrimidine Dimers in Human Cells in Vitro

J. Trosko, M. Isoun, D. Krause, 1970, Nature.

Gap junctional intercellular communication in mouse lung epithelial cell lines: effects of cell transformation and tumor promoters.

A. Malkinson, J. Trosko, K. Sigler, 1993, Cancer letters.

An integrative hypothesis linking cancer, diabetes and atherosclerosis: the role of mutations and epigenetic changes.

J. Trosko, C. Chang, 1980, Medical hypotheses.

Characterization of a rat liver epithelial cell line to detect inhibitors of metabolic cooperation

J. Trosko, C. Jone, C. Chang, 1987, In Vitro Cellular & Developmental Biology.

Cytotoxic, mutagenic, and cell-cell communication inhibitory properties of DDT, lindane, and chlordane on Chinese hamster cellsin vitro

J. Trosko, F. Matsumura, G. Tsushimoto, 1983, Archives of environmental contamination and toxicology.

STRANDEDNESS OF VICIA FABA CHROMOSOMES AS REVEALED BY ENZYME DIGESTION STUDIES

J. Trosko, S. Wolff, 1965, The Journal of cell biology.

Is the transition from chromosome to chromatid aberrations the result of the formation of single-stranded DNA?

J. Trosko, J. Heddle, 1966, Experimental cell research.

Potential Role of Intercellular Communication in the Rate-Limiting Step in Carcinogenesis

J. Trosko, Chia‐cheng Chang, 1983 .

C-erbB2/neu Transfection Induces Gap Junctional Communication Incompetence in Glial Cells

J. Trosko, Chia‐cheng Chang, D. Spray, 1996, The Journal of Neuroscience.

Applicability of Scrape Loading-Dye Transfer Assay for Non-Genotoxic Carcinogen Testing

J. Trosko, P. Babica, I. Sovadinová, 2021, International journal of molecular sciences.

Ignored Hallmarks of Carcinogenesis: Stem Cells and Cell‐Cell Communication

J. Trosko, Chia‐cheng Chang, B. Upham, 2004, Annals of the New York Academy of Sciences.

Effect of electromagnetic field exposure on chemically induced differentiation of friend erythroleukemia cells.

E. Rothwell, K. M. Chen, J. Trosko, 2000, Environmental health perspectives.

Diet/Nutrition, Inflammation, Cellular Senescence, Stem Cells, Diseases of Aging, and Aging

J. Trosko, K. Kang, M. Tai, 2014 .

Review Paper: Cancer Stem Cells and Cancer Nonstem Cells: From Adult Stem Cells or from Reprogramming of Differentiated Somatic Cells

J. Trosko, 2009, Veterinary pathology.

Molecular Profiling of Potential Human Prostate Cancer Stem Cells

J. Trosko, K. Kang, G. Carruba, 2013 .

Microrna-1285 Might Potentially Regulate OCT4 Gene Expression By Direct Targeting of Its Promoter

J. Trosko, Majid Mehravar, E. Poursani, 2016 .

Oxidative stress-induced biomarkers for stem cell-based chemical screening.

J. Trosko, I. Rahman, K. Kang, 2012, Preventive medicine.

Factors to consider in the use of stem cells for pharmaceutic drug development and for chemical safety assessment.

Chia-Cheng Chang, J. Trosko, Chia‐cheng Chang, 2010, Toxicology.

Cancer: A Stem Cell-based Disease?

J. Trosko, 2009 .

Human adult stem cells as the target cells for the initiation of carcinogenesis and for the generation of "cancer stem cells".

J. Trosko, 2008, International journal of stem cells.

Commentary: “Re-Programming or Selecting Adult Stem Cells?”

J. Trosko, 2008, Stem Cell Reviews.

Epigenetics and cancer: implications for drug discovery and safety assessment.

J. Trosko, J. Moggs, R. Roberts, 2004, Toxicology and applied pharmacology.

Induction of iPS Cells and of Cancer Stem Cells: The Stem Cell or Reprogramming Hypothesis of Cancer?

J. Trosko, 2014, Anatomical record.

Elevated spontaneous mutation rate in Bloom syndrome fibroblasts.

S. Warren, J. Trosko, M. Wade, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Global Health Crisis Caused by the Collision of Biological and Cultural Evolution: Pre-Natal Influences on Acute and Chronic Diseases in Later Life

J. Trosko, 2014 .

Involvement of tyrosine phosphorylation of p185c‐erbB2/neu in tumorigenicity induced by x‐rays and the neu oncogene in human breast epithelial cells

J. Trosko, Chia‐cheng Chang, Chia-Jen Liu, 1998, Molecular carcinogenesis.

Human health consequences of environmentally-modulated gene expression: potential roles of ELF-EMF induced epigenetic versus mutagenic mechanisms of disease.

J. Trosko, 2000, Bioelectromagnetics.

Dietary Modulation of the Multistage, Multimechanisms of Human Carcinogenesis: Effects on Initiated Stem Cells and Cell–Cell Communication

J. Trosko, 2006, Nutrition and cancer.

Adult stem cell theory of the multi-stage, multi-mechanism theory of carcinogenesis: role of inflammation on the promotion of initiated stem cells.

J. Trosko, M. Tai, 2006, Contributions to microbiology.

Intercellular Communication: A Paradigm for the Interpretation of the Initiation/Promotion/Progression Model of Carcinogenesis

J. Trosko, Chia‐cheng Chang, B. Madhukar, 1995 .

Modulation of intercellular communication during radiation and chemical carcinogenesis.

J. Trosko, B. Madhukar, C. Chang, 1990, Radiation research.

Stem cell theory of carcinogenesis.

J. Trosko, C. Chang, 1989, Toxicology letters.

Mechanisms of tumor promotion: possible role of inhibited intercellular communication.

J. Trosko, 1987, European journal of cancer & clinical oncology.

'A failed paradigm: carcinogenesis is more than mutagenesis'.

J. Trosko, 1988, Mutagenesis.

The transport of reactive intermediates in a co-cultivation system: the role of intercellular communication.

J. Trosko, W. Jongen, B. M. van der Leede, 1987, Carcinogenesis.

The Concept of “Cancer Stem Cells” in the Context of Classic Carcinogenesis Hypotheses and Experimental Findings

J. Trosko, 2021, Life.

Reflections on the use of 10 IARC carcinogenic characteristics for an objective approach to identifying and organizing results from certain mechanistic studies

James E. Trosko, J. Trosko, 2017 .

Inhibited intercellular communication as a mechanistic link between teratogenesis and carcinogenesis.

J. Trosko, R. Loch-Caruso, 1985, Critical reviews in toxicology.

Role of tumor promotion in affecting the multi-hit nature of carcinogenesis.

J. Trosko, C. Chang, 1985, Basic life sciences.

Cloning of human stem cells: some broad scientific and philosophical issues.

J. Trosko, 2000, The Journal of laboratory and clinical medicine.

A Human Breast Epithelial Cell Type with Stem Cell Characteristics as Target Cells for Carcinogenesis

J. Trosko, Chia‐cheng Chang, M. Saitoh, 2001, Radiation research.

High susceptibility of a human breast epithelial cell type with stem cell characteristics to telomerase activation and immortalization.

J. Trosko, Chia‐cheng Chang, I. Morita, 1999, Cancer research.

PBB inhibits metabolic cooperation in Chinese hamster cells in vitro: its potential as a tumor promoter.

J. Trosko, B. Dawson, C. Chang, 1981, Environmental health perspectives.

Potential role of the human Ha‐ras oncogene in the inhibition of gap junctional intercellular communication

S. Warren, J. Trosko, Chia‐cheng Chang, 1989, Molecular carcinogenesis.

Determination of the epigenetic effects of ochratoxin in a human kidney and a rat liver epithelial cell line.

J. Trosko, A. Horvath, B. Upham, 2002, Toxicon : official journal of the International Society on Toxinology.

Adaptive and nonadaptive consequences of chemical inhibition of intercellular communication.

J. Trosko, C. Chang, 1984, Pharmacological reviews.

Elimination of metabolic cooperation is associated with the tumor promoters, oleic acid and anthralin.

J. Trosko, C. Jone, C. Aylsworth, 1982, Carcinogenesis.

In vitro assay for tumor promoters and anti-promoters.

S. Warren, J. Trosko, C. Chang, 1978, Journal of environmental pathology and toxicology.

Environmental Carcinogenesis: An Integrative Model

J. Trosko, C. Chang, 1978, The Quarterly Review of Biology.

Modulation of Cell-Cell Communication and Epigenetic Mechanisms as a Shared Cellular Mechanism in Diverse Childhood Brain Diseases, Such as Cancer and Autism

J. Trosko, 2018 .

Towards Understanding Carcinogenic Hazards: A Crisis in Paradigms

J. Trosko, 1989 .

The Role of Inhibited Intercellular Communication in Carcinogenesis: Implications for Risk Assessment from Exposure to Chemicals

J. Trosko, C. Chang, 1989 .

Alteration of calcium transport by tumor promoters, 12-O-tetradecanoyl phorbol-13-acetate and p,p'-dichlorodiphenyltrichloroethane, in the Chinese hamster V79 fibroblast cell line.

J. Trosko, F. Matsumura, B. Madhukar, 1983, Cancer letters.

Chemical, oncogene and growth factor inhibition gap junctional intercellular communication: an integrative hypothesis of carcinogenesis.

J. Trosko, B. Madhukar, J. Klaunig, 1990, Pathobiology : journal of immunopathology, molecular and cellular biology.

Role of low-level ionizing radiation in multi-step carcinogenic process.

J. Trosko, 1996, Health physics.

Characterization of Gap Junctional Intercellular Communication in Immortalized Human Pancreatic Ductal Epithelial Cells With Stem Cell Characteristics

L. Olson, J. Trosko, M. Tsao, 2003, Pancreas.

Methoxychlor and Vinclozolin Induce Rapid Changes in Intercellular and Intracellular Signaling in Liver Progenitor Cells.

J. Trosko, P. Babica, Libor Jaša, 2016, Toxicological sciences : an official journal of the Society of Toxicology.

Oxidative-dependent integration of signal transduction with intercellular gap junctional communication in the control of gene expression.

J. Trosko, B. Upham, 2009, Antioxidants & redox signaling.

A Paradigm Shift in the Understanding of Oxidative Stress and its Implications to Exposure of Low-level Ionizing Radiation

J. Trosko, B. Upham, 2005 .

β-Sitosterol From Psyllium Seed Husk (Plantago ovata Forsk) Restores Gap Junctional Intercellular Communication in Ha-ras Transfected Rat Liver Cells

J. Trosko, Chia‐cheng Chang, Yasushi Nakamura, 2005 .

Anisomycin downregulates gap-junctional intercellular communication via the p38 MAP-kinase pathway

N. Yorioka, J. Trosko, D. Macphee, 2004, Journal of Cell Science.

Inhibition of gap junctional intercellular communication by noncoplanar polychlorinated biphenyls: inhibitory potencies and screening for potential mode(s) of action.

J. Trosko, J. Vondráček, M. Machala, 2003, Toxicological sciences : an official journal of the Society of Toxicology.

Inhibition of gap junctional intercellular communication by perfluorinated compounds in rat liver and dolphin kidney epithelial cell lines in vitro and Sprague-Dawley rats in vivo.

Wenyue Hu, Paul D Jones, John P Giesy, 2002, Toxicological sciences : an official journal of the Society of Toxicology.

Cell population dynamics (apoptosis, mitosis, and cell-cell communication) during disruption of homeostasis.

J. Trosko, M. Wilson, Melinda R. Wilson, 2000, Experimental cell research.

Polycyclic aromatic hydrocarbons with bay-like regions inhibited gap junctional intercellular communication and stimulated MAPK activity.

J. Trosko, M. Wilson, B. Upham, 1999, Toxicological sciences : an official journal of the Society of Toxicology.

Assessment of Gap Junctional Intercellular Communication in Living Cells Using Fluorescence Techniques

J. Trosko, M. Wade, A. W. D. Feijter, 1999 .

Bay or baylike regions of polycyclic aromatic hydrocarbons were potent inhibitors of Gap junctional intercellular communication.

J. Trosko, S. Masten, B. Upham, 1998, Environmental health perspectives.

Loss of gap junctions from DDT-treated rat liver epithelial cells.

J. Trosko, K. Sigler, D. Matesic, 1994, Carcinogenesis.

Inhibition of gap junction-mediated intercellular communication by alpha-linolenate.

J. Trosko, C. Hasler, M. Bennink, 1991, The American journal of physiology.

Modulated Intercellular Communication: Consequence of Extracellular Molecules Triggering Intracellular Communication

J. Trosko, C. Hasler, B. Madhukar, 1991 .

Trosko Reprogramming of Differentiated Somatic Cells Review Paper : Cancer Stem Cells and Cancer Nonstem Cells : From Adult Stem Cells or from

J. Trosko, 2010 .

Growth-promoting Effect of 12-0-TetradecanoyIphorboI-13-acetate on Cultured Normal Human Fetal Kidney Epithelial Cells1

J. Trosko, Chia‐cheng Chang, S. D'Ambrosio, 2006 .

Effect of PhorbolMyristate Acetate on the Recoveryof Spontaneousand Ultraviolet Light-induced 6-Thioguanineand Ouabain-resistantChinese HamsterCells1

J. Trosko, Chia‐cheng Chang, L. Yotti, 1976 .

Cigarette smoke components inhibited intercellular communication and differentiation in human pancreatic ductal epithelial cells

L. Olson, J. Trosko, M. Tsao, 2007, International journal of cancer.

Growth suppression of a tumorigenic rat liver cell line by the anticancer agent, ET-18-O-CH3, is mediated by inhibition of cytokinesis

J. Trosko, Chia‐cheng Chang, H. Na, 2003, Cancer Chemotherapy and Pharmacology.

Growth suppression of a tumorigenic rat liver cell line by the anticancer agent, ET-18-O-CH 3

J. Trosko, Chia‐cheng Chang, H. Na, 2003 .

Cooperation of bcl-2 and myc in the neoplastic transformation of normal rat liver epithelial cells is related to the down-regulation of gap junction-mediated intercellular communication.

J. Trosko, M. Wilson, N. D. Deocampo, 2000, Carcinogenesis.

The Emperor Wears No Clothes in the Field of Carcinogen Risk Assessment: Ignored Concepts in Cancer Risk Assessment

J. Trosko, B. Upham, James E. Trosko, 2005 .

Cooperative effects of v-myc and c-Ha-ras oncogenes on gap junctional intercellular communication and tumorigenicity in rat liver epithelial cells.

J. Trosko, R. Ruch, T. Hayashi, 1998, Cancer letters.

A fluorescence photobleaching assay of gap junction-mediated communication between human cells.

J. Trosko, M. Schindler, M. Wade, 1986, Science.

3-Methylthiopropionic acid ethyl ester, isolated from Katsura-uri (Japanese pickling melon, Cucumis melo var. conomon), enhanced differentiation in human colon cancer cells.

J. Trosko, Chia‐cheng Chang, H. Ando, 2008, Journal of agricultural and food chemistry.

The effect of acrylonitrile on gap junctional intercellular communication in rat astrocytes

J. Trosko, J. Klaunig, L. Kamendulis, 1999, Cell Biology and Toxicology.

Inhibition of gap junctional-mediated intercellular communication in vitro by aldrin, dieldrin, and toxaphene: a possible cellular mechanism for their tumor-promoting and neurotoxic effects.

J. Trosko, C. Jone, C. Chang, 1987, Molecular toxicology.

Effect of cholesterol epoxides on the inhibition of intercellular communication and on mutation induction in Chinese hamster V79 cells.

J. Trosko, A. Sevanian, A. R. Peterson, 1988, Mutation research.

Assessment of the carcinogenic potential of a proposed food coloring additive, laccaic acid, using short-term assays

L. Loeb, J. Trosko, R. Loch-Caruso, 1984, Cell Biology and Toxicology.

Inhibition of metabolic cooperation in Chinese hamster V79 cells by various organic solvents and simple compounds

J. Trosko, T. H. Chen, C. Chang, 1984, Cell Biology and Toxicology.

Commentary: Is the concept of “tumor promotion” a useful paradigm?

J. Trosko, J E Trosko, 2001, Molecular carcinogenesis.

Characterization of a human teratocarcinoma cell assay for inhibitors of metabolic cooperation.

J. Trosko, T. Kavanagh, C. Chang, 1986, Cancer research.

The role of human adult stem cells and cell-cell communication in cancer chemoprevention and chemotherapy strategies.

J. Trosko, Chia‐cheng Chang, B. Upham, 2005, Mutation research.

The role of stem cells and gap junctions as targets for cancer chemoprevention and chemotherapy.

J. Trosko, 2005, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

What are the Origins and Characteristics of Cancer Stem Cells?

J. Trosko, 2019 .

Mechanisms of Epigenetic Toxicity in the Pathogenesis of Cancer for "Precision Medicine"

J. Trosko, 2018, Journal of Cancer Treatment and Diagnosis.

Commentary: How Evolution of Quorum Sensing Must Fit into the Understanding of The Origin, Prevention and Treatment of cancer

J. Trosko, 2017 .

A Conceptual Integration of Extra-, Intra- and Gap Junctional- Intercellular Communication in the Evolution of Multi-cellularity and Stem Cells: How Disrupted Cell-Cell Communication during Development can Affect Diseases later in Life

J. Trosko, 2016 .

Evolution of Microbial Quorum Sensing to Human Global Quorum Sensing: An Insight into How Gap Junctional Intercellular Communication Might Be Linked to the Global Metabolic Disease Crisis

J. Trosko, 2016, Biology.

Expression of the Embryonic Transcription Factor Oct4 in Canine Neoplasms: A Potential Marker for Stem Cell Subpopulations in Neoplasia

J. Trosko, J. Webster, M. Kiupel, 2007, Veterinary pathology.

Gap Junctional Intercellular Communication as a Biological “Rosetta Stone” in Understanding, in a Systems Biological Manner, Stem Cell Behavior, Mechanisms of Epigenetic Toxicology, Chemoprevention and Chemotherapy

J. Trosko, 2007, Journal of Membrane Biology.

Isolation and partial characterization of mutagen-sensitive and DNA repair mutants of Chinese hamster fibroblasts.

J. Trosko, R. Schultz, C. Chang, 1981, Environmental mutagenesis.

Photoreactivation of ultraviolet light-induced pyrimidine dimers in Ginkgo cells grown in vitro.

J. Trosko, V. H. Mansour, 1969, Mutation research.

EFFECT ON GENETIC DAMAGE OF POSTTREATMENTS GIVEN X-RAYED DROSOPHILA MALES.

J. Trosko, 1964, Genetics.

Radiation risk to low fluences of α particles may be greater than we thought

James E. Trosko, Gerhard Randers-Pehrson, Tom K. Hei, 2001, Proceedings of the National Academy of Sciences of the United States of America.

The possible effect of diazepam on cancer development and growth.

D F Horrobin, J. Trosko, D. Horrobin, 1981, Medical hypotheses.

One Health

J. Trosko, Christina Dokter, R. Nassiri, 2016, University Partnerships for International Development.

Concepts needed to understand potential health effects of chronic low-level radiation exposures: Role of adult stem cells and modulated cell–cell communication

J. Trosko, 2007 .

The chemopreventive role of dietary phytochemicals through gap junctional intercellular communication

J. Trosko, A. Leone, Cristiano Longo, 2012, Phytochemistry Reviews.

Commentary on ‘‘Toxicity Testing in the 21st Century: A vision and a Strategy’’: Stem Cells and Cell-Cell Communication as Fundamental Targets in Assessing the Potential Toxicity of Chemicals

J. Trosko, 2010, Human & experimental toxicology.

From Adult Stem Cells to Cancer Stem Cells

J. Trosko, 2006 .

Symposium: Cell Communication in Normal and Uncontrolled Growth.

J. Trosko, B. Madhukar, C. Chang, 1990 .

On the Potential Origin and Characteristics of Cancer Stem Cells.

J. Trosko, 2021, Carcinogenesis.

The Role of the Mitochondria in the Evolution of Stem Cells, Including MUSE Stem Cells and Their Biology.

J. Trosko, 2018, Advances in experimental medicine and biology.

What roles do colon stem cells and gap junctions play in the left and right location of origin of colorectal cancers?

J. Trosko, H. Lenz, 2017, Journal of Cell Communication and Signaling.

Pre-Natal Epigenetic Influences on Acute and Chronic Diseases Later in Life, such as Cancer: Global Health Crises Resulting from a Collision of Biological and Cultural Evolution

J. Trosko, 2011 .

Modification of UV-induced mutation frequencies in Chinese hamster cells by dose fractionation, cycloheximide and caffeine treatments.

R. Setlow, J. Trosko, S. D'Ambrosio, 1978, Mutation research.

Regulation of Glycoconjugate Metabolism in Normal and Transformed Cells

C. C. Marvel, S. Warren, J. Trosko, 1980 .

Augmentation of differentiation and gap junction function by kaempferol in partially differentiated colon cancer cells.

J. Trosko, Chia‐cheng Chang, Toshio Mori, 2004, Carcinogenesis.

Hepatic tumor-promoting ability of 3,3',4,4',5,5'-hexabromobiphenyl: the interrelationship between toxicity, induction of hepatic microsomal drug metabolizing enzymes, and tumor-promoting ability.

J I Goodman, J. Trosko, S. Aust, 1983, Toxicology and applied pharmacology.

Mechanism of up-regulated gap junctional intercellular communication during chemoprevention and chemotherapy of cancer.

J. Trosko, Chia‐cheng Chang, C. Chang, 2001, Mutation research.

Cytological observations on the strandedness of mammalian metaphase chromosomes.

J. G. Brewen, J. Trosko, J. Brewen, 1966, Cytologia.

Mutagenic characterization of cholesterol epoxides in Chinese hamster V79 cells.

J. Trosko, A. Sevanian, A. R. Peterson, 1988, Mutation research.

The role of modulated gap junctional intercellular communication in epigenetic toxicology.

J. Trosko, B. Madhukar, C. Chang, 1994, Risk analysis : an official publication of the Society for Risk Analysis.

Pro-Apoptotic Effect of Grape Seed Extract on MCF-7 Involves Transient Increase of Gap Junction Intercellular Communication and Cx43 Up-Regulation: A Mechanism of Chemoprevention

J. Trosko, A. Leone, C. Gerardi, 2019, International journal of molecular sciences.

Induction of gap junctional intercellular communication, connexin43 expression, and subsequent differentiation in human fetal neuronal cells by stimulation of the cyclic AMP pathway

J. Trosko, C. V. Dowling-Warriner, 1999, Neuroscience.

Hierarchical and cybernetic nature of biologic systems and their relevance to homeostatic adaptation to low-level exposures to oxidative stress-inducing agents.

J. Trosko, J E Trosko, 1998, Environmental health perspectives.

PHOTOREACTIVATION OF ULTRAVIOLET LIGHT-INDUCED INHIBITION OF DNA SYNTHESIS IN TOBACCO CELLS GROWN IN VITRO.

J. Trosko, V. H. Mansour, 1969 .

Biomarkers for low-level exposure causing epigenetic responses in stem cells.

J. Trosko, 1995, Stem cells.

A Possible Mechanistic Link between Teratogenesis and Carcinogenesis: Inhibited Intercellular Communication

J. Trosko, Chia‐cheng Chang, 1984 .

Hypermutability of a UV-sensitive aphidicolin-resistant mutant of Chinese hamster fibroblasts.

J. Trosko, P. Liu, C. Chang, 1982, Mutation research.

Thymidylate synthetase gene as a quantitative mutation marker in Chinese hamster cells.

J. Trosko, Chia‐cheng Chang, I. Li, 1990, Mutation research.

Errarum: Oct4 expression in adult stem cells: Evidence in support of the stem cell theory of carcinogenesis (Carcinogenesis (2005) Vol. 26 (495-502))

L. Olson, J. Trosko, Chia‐cheng Chang, 2005 .

Categorizing the characteristics of human carcinogens: a need for specificity

J. Trosko, C. Begley, A. Hayes, 2021, Archives of Toxicology.

Contact insensitivity of a subpopulation of normal human fetal kidney epithelial cells and of human carcinoma cell lines.

J. Trosko, S. D'Ambrosio, M. H. El-Fouly, 1987, Cancer research.

The modulation of gap junctional communication by gossypol in various mammalian cell lines in vitro.

T. Akera, J. Trosko, Y. Ye, 1990, Fundamental and applied toxicology : official journal of the Society of Toxicology.

Oxidative stress, signal transduction, and intercellular communication in radiation carcinogenesis

J. Trosko, Tohru Inoue, 1997, Stem cells.

Changes in gap‐junction permeability, phosphorylation, and number mediated by phorbol ester and non‐phorbol‐ester tumor promoters in rat liver epithelial cells

J. Trosko, D. Matesic, R. Ruch, 1994, Molecular carcinogenesis.

Metformin Represses Self-Renewal of the Human Breast Carcinoma Stem Cells via Inhibition of Estrogen Receptor-Mediated OCT4 Expression

J. Trosko, K. Kang, Soo-Jin Lee, 2011, PloS one.

Effect of various polybrominated biphenyls on cell-cell communication in cultured human teratocarcinoma cells.

J. Trosko, T. Kavanagh, C. Chang, 1987, Fundamental and applied toxicology : official journal of the Society of Toxicology.

Polybrominated biphenyls as promoters in experimental hepatocarcinogenesis in rats.

J. Trosko, S. Aust, J. Goodman, 1982, Carcinogenesis.

Gap junctions and fluid flow response in MC3T3-E1 cells.

C. Jacobs, J. Trosko, H. Donahue, 2001, American journal of physiology. Cell physiology.

Inhibition of intercellular communication in cultures of Chinese hamster V79 cells by 2,4-dichlorophenoxyacetic acid and 2,4,5-trichlorophenoxyacetic acid.

J. Trosko, C. Jone, C. Rubinstein, 1984, Fundamental and applied toxicology : official journal of the Society of Toxicology.

Studies on deoxyribonucleic acid metabolism in human cells treated with lysergic acid diethylamide.

J. Trosko, 1971, Biochemical pharmacology.

Radiation risk to low fluences of alpha particles may be greater than we thought.

J. Trosko, T. Hei, G. Randers-Pehrson, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Isolation and differentiation of bovine mammary gland progenitor cell populations.

J. Trosko, R. Holland, J. Stasko, 2003, American journal of veterinary research.

Epigenetic toxicology as toxicant-induced changes in intracellular signalling leading to altered gap junctional intercellular communication.

J. Trosko, Chia‐cheng Chang, M. Wilson, 1998, Toxicology letters.

Inhibition of gap junctional intercellular communication in human teratocarcinoma cells by organochlorine pesticides.

J. Trosko, Chia‐cheng Chang, T. Kavanagh, 1986, Toxicology and applied pharmacology.

Induction by 7,12-dimethylbenz(a)anthracene of molecular and biochemical alterations in transformed human mammary epithelial stem cells, and protection by N-acetylcysteine.

S. De Flora, F. D'Agostini, A. Izzotti, 2006, International journal of oncology.

In vitro growth inhibition of neoplastically transformed cells by non-transformed cells: requirement for gap junctional intercellular communication.

J. Trosko, R. Ruch, C. Chang, 1995, Carcinogenesis.

“Bad Luck Mutations”: DNA Mutations Are not the Whole Answer to Understanding Cancer Risk

J. Trosko, G. Carruba, 2017, Dose-response : a publication of International Hormesis Society.

Modulation of connexin 43 in rotenone-induced model of Parkinson's disease

J. Trosko, Y. Kotake, S. Ohta, 2009, Neuroscience.

Melatonin decreases estrogen receptor binding to estrogen response elements sites on the OCT4 gene in human breast cancer stem cells

D. Arnosti, J. Trosko, D. Zuccari, 2016, Genes & cancer.

Cancer Prevention and Therapy of Two Types of Gap Junctional Intercellular Communication–Deficient “Cancer Stem Cell”

J. Trosko, 2019, Cancers.

In Search of a Unifying Concept in Human Diseases

J. Trosko, 2021, Diseases.

How evolution of quorum sensing must fit into the understanding ofthe origin, prevention and treatment of cancer

J. Trosko, 2018 .

Precision Medicine for Childhood Cancers: Role of Epigenetics in Childhood Cancers

J. Trosko, 2017 .

From bacteria to humans: Lessons learned from a reductionist's view of ultraviolet light‐induced DNA lesions

J. Trosko, 2001, Environmental and molecular mutagenesis.

Functional plasticity and cell specific expression of connexins in normal and pathological glial tissues

J. Trosko, C. Müller, R. Dermietzel, 1995 .

Chemical Tumor Promoters, Oncogenes and Growth Factors: Modulators of Gap Junctional Intercellular Communication

J. Trosko, 1991 .

Dieldrin inhibition of gap junctional intercellular communication in rat glial cells as measured by the fluorescence photobleaching and scrape loading/dye transfer assays.

J. Trosko, S. Suter, M. H. El-Fouly, 1987, Fundamental and applied toxicology : official journal of the Society of Toxicology.

Potential role of mutations and inhibited intercellular communication in the genesis of some chronic diseases

J. Trosko, 1982 .

Evaluation of the carcinogenic potential of 2,4-dinitrofluorobenzene and its implications regarding mutagenicity testing.

S. Warren, J. Trosko, D. Doolittle, 1982, Carcinogenesis.

In vitro analysis of modulators of intercellular communication: Implications for biologically, based risk assessment models for chemical exposure.

J. Trosko, B. Madhukar, J E Trosko, 1990, Toxicology in vitro : an international journal published in association with BIBRA.

Epigenetic toxicity of hydroxylated biphenyls and hydroxylated polychlorinated biphenyls on normal rat liver epithelial cells.

J. Trosko, S. Masten, Andrea Y Satoh, 2003, Environmental science & technology.

Expression of Oct-4, alpha fetoprotein and vimentin, and lack of gap-junctional intercellular communication (GJIC) as common phenotypes for human adult liver stem cells and hepatoma cells

J. Trosko, Chia‐cheng Chang, K. Kuo, 2004 .

Upregulation of gap junctional intercellular communication in immortalized gonadotropin-releasing hormone neurons by stimulation of the cyclic AMP pathway.

J. Trosko, D. Matesic, J. Germak, 1996, Neuroendocrinology.

Gap junctions and ﬂuid ﬂow response in MC3T3-E1 cells

C. Jacobs, J. Trosko, H. Donahue, 2001 .

Deoxyribonuclease and deoxyribonucleic acid polymerase activity during Drosophila development.

J. Trosko, A. Muhammed, J. M. Goncalves, 1967, Developmental biology.

Human breast stem cells as a toxicological model for endocrine disruptors, such as soy isoflavones

J. Trosko, A. Lampen, Sandra Stempin, 2012 .

Low-dose ionizing radiation: induction of differential intracellular signalling possibly affecting intercellular communication

J. Trosko, Chia‐cheng Chang, B. Upham, 2005, Radiation and environmental biophysics.

Synergistic inhibition of metabolic cooperation by oleic acid or 12-0-tetradecanoylphorbol-13-acetate and dichlorodiphenyltrichlorethane (DDT) in Chinese hamster V79 cells: Implication of a role for protein kinase C in the regulation of gap junctional intercellular communication

J. Trosko, Chia‐cheng Chang, C. Aylsworth, 2004, Cell Biology and Toxicology.

Epigenetic toxicity of a mixture of polycyclic aromatic hydrocarbons on gap junctional intercellular communication before and after biodegradation

J. Trosko, W. Weber, S. Ghoshal, 1999 .

Actin and Vimentin proteins with N‐terminal deletion detected in tumor‐bearing rat livers induced by intraportal‐vein injection of Ha‐ras‐transfected rat liver cells

J. Trosko, Chia‐cheng Chang, Yasushi Nakamura, 2009, International journal of cancer.

Beta-sitosterol from psyllium seed husk (Plantago ovata Forsk) restores gap junctional intercellular communication in Ha-ras transfected rat liver cells.

J. Trosko, Chia‐cheng Chang, Yasushi Nakamura, 2005, Nutrition and cancer.

Profiling Cancer Stem Cells in Androgen‐Responsive and Refractory Human Prostate Tumor Cell Lines

J. Trosko, K. Kang, G. Carruba, 2009, Annals of the New York Academy of Sciences.

In situ PYRIMIDINE DIMER DETERMINATION BY LASER CYTOMETRY

J. Trosko, Chia‐cheng Chang, A. Wani, 1989, Photochemistry and photobiology.

Evidence for mutagenic repair in V79 cell mutant with aphidicolin-resistant DNA polymerase-α

J. Trosko, Chia‐cheng Chang, James E. Trosko, 1984, Somatic cell and molecular genetics.

THE ROLE OF TUMOR PROMOTERS ON PHENOTYPIC ALTERATIONS AFFECTING INTERCELLULAR COMMUNICATION AND TUMORIGENESIS *

J. Trosko, Chia‐cheng Chang, C. Jone, 1983, Annals of the New York Academy of Sciences.

Isolation and characterization of a UV-sensitive hypermutable aphidicolin-resistant Chinese hamster cell line

S. Warren, J. Trosko, Chia‐cheng Chang, 1982, Somatic cell genetics.

Science, innovation and society

R. Sharpe, A. Salonen, J. Trosko, 2016 .

Characterization of ret oncogenic activation in MEN2 inherited cancer syndromes.

J. Trosko, S. Jhiang, E. Mazzaferri, 1996, Endocrinology.

Profiling Cancer Stem Cells in Androgen‐Responsive and Refractory Human Prostate Tumor Cell Lines

J. Trosko, K. Kang, G. Carruba, 2009, Annals of the New York Academy of Sciences.

Serum from outdated human platelet concentrates: An alternative supplement for tissue (fibroblast) culture media

J. Trosko, Chia‐cheng Chang, K. Schwartz, 1984, American journal of hematology.

The emperor wears no clothes in the field of carcinogen risk assessment: ignored concepts in cancer risk assessment.

J. Trosko, B. Upham, 2005, Mutagenesis.

Stem cells in toxicology: fundamental biology and practical considerations.

J. Trosko, K. Kang, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

A Historical Perspective for the Development of Mechanistic-Based 3D Models of Toxicology Using Human Adult Stem Cells.

J. Trosko, 2018, Toxicological sciences : an official journal of the Society of Toxicology.

Fluorescence photobleaching assay of tumor promoter 12-O-tetradecanoylphorbol 13-acetate inhibition of cell-cell communication.

J. Trosko, M. Schindler, M. Wade, 1987, Methods in Enzymology.

Assessment of Hepatotoxic Potential of Cyanobacterial Toxins Using 3D In Vitro Model of Adult Human Liver Stem Cells.

J. Trosko, P. Babica, L. Bláha, 2018, Environmental science & technology.

AN INTEGRATIVE MODEL

J. Trosko, Chia‐cheng Chang, 1978 .

Metabolic cooperation in CHO and V79 cells following treatment with a tumor promoter.

S. Warren, J. Trosko, J. Moskal, 1981, Experimental cell research.

Comments on "What is a tumor promoter?".

J. Trosko, 1999, Environmental health perspectives.

Flow cytometry and scrape-loading/dye transfer as a rapid quantitative measure of intercellular communication in vitro.

P. Rabinovitch, J. Trosko, G. Martin, 1987, Cancer research.

Flow Cytometry and Scrape-loading / Dye Transfer as a Rapid Quantitative Measure of Intercellular Communication in Vitro 1

P. Rabinovitch, J. Trosko, Chia‐cheng Chang, 2006 .

Flow Cytometry and Scrape-loading/Dye Transfer as a Rapid Quantitative Measure of Intercellular Communication in Vitro1

P. Rabinovitch, J. Trosko, Chia‐cheng Chang, 2006 .

Are We Still Missing the Target in Trying to Prevent and Treat Human Cancers?

J. Trosko, 2019, Novel Approaches in Cancer Study.

Cell-to-cell communication: relationship of stem cells to the carcinogenic process.

J. Trosko, B. Madhukar, C. Chang, 1990, Progress in clinical and biological research.

Comments on the paper by J. Morrow

J. Trosko, E. Chu, 1972 .

The mutation studies of mutagen-sensitive and DNA repair mutants of Chinese hamster fibroblasts.

J. Trosko, R. Schultz, C. Chang, 1981, Environmental mutagenesis.

J. Trosko, J. Vondráček, M. Machala, 2008, Cancer science.

Ecology and Our Endangered Life-Support Systems.Eugene P. OdumGlobal Bioethics: Building on the Leopold Legacy.Van Rensselaer Potter

J. Trosko, 1990 .

GAP-JUNCTION COMMUNICATION IN CHEMICAL CARCINOGENESIS

J. Trosko, R. Ruch, James E. Trosko, 2001, Drug metabolism reviews.

Laser scanning analysis of cell-cell communication in cultured human prostate tumor cells.

M. Webber, J. Trosko, G. Carruba, 1999, Analytical and quantitative cytology and histology.