I. Abe

发表

Green tea polyphenols: novel and potent inhibitors of squalene epoxidase.

I. Abe, T. Seki, K. Umehara, 2000, Biochemical and biophysical research communications.

Deciphering the Biosynthetic Mechanism of Pelletierine in Lycopodium Alkaloid Biosynthesis.

I. Abe, Juan Wang, P. Tu, 2020, Organic letters.

ENZYMATIC CYCLIZATION OF SQUALENE AND OXIDOSQUALENE TO STEROLS AND TRITERPENES

G. Prestwich, I. Abe, M. Rohmer, 1993 .

Calyculin biogenesis from a pyrophosphate protoxin produced by a sponge symbiont.

I. Abe, Y. Asakawa, T. Wakimoto, 2014, Nature chemical biology.

The Oxidosqualene Cyclases: One Substrate, Diverse Products

I. Abe, 2014 .

Biosynthesis of clinically used antibiotic fusidic acid and identification of two short-chain dehydrogenase/reductases with converse stereoselectivity

I. Abe, X. Yao, Guo-dong Chen, 2018, Acta pharmaceutica Sinica. B.

A specific amino acid repeat in squalene and oxidosqualene cyclases.

G. Prestwich, K. Poralla, I. Abe, 1994, Trends in biochemical sciences.

2.10 – Squalene Epoxidase and Oxidosqualene : Lanosterol Cyclase—Key Enzymes in Cholesterol Biosynthesis

I. Abe, 1999 .

Chojalactones A-C, cytotoxic butanolides isolated from Streptomyces sp. cultivated with mycolic acid containing bacterium.

I. Abe, T. Wakimoto, H. Onaka, 2015, Organic letters.

A structure-based mechanism for benzalacetone synthase from Rheum palmatum

I. Abe, H. Noguchi, M. Tanio, 2009, Proceedings of the National Academy of Sciences.

Structure and function of the chalcone synthase superfamily of plant type III polyketide synthases.

Hiroyuki Morita, Ikuro Abe, I. Abe, 2010, Natural product reports.

Alkylresorcinol Synthases Expressed in Sorghum bicolor Root Hairs Play an Essential Role in the Biosynthesis of the Allelopathic Benzoquinone Sorgoleone[W][OA]

Joachim Schröder, Franck E Dayan, Stephen O Duke, 2010, Plant Cell.

Acyltransferase that catalyses the condensation of polyketide and peptide moieties of goadvionin hybrid lipopeptides

I. Abe, Hidenori Takahashi, Koichi Tanaka, 2020, Nature Chemistry.

Replacement of a quinone by a 5-O-acetylhydroquinone abolishes the accidental necrosis inducing effect while preserving the apoptosis-inducing effect of renieramycin M on lung cancer cells.

I. Abe, P. Chanvorachote, K. Suwanborirux, 2013, Journal of natural products.

Dinorcassane Diterpenoid from Boesenbergia rotunda Rhizomes Collected in Lower Myanmar

Prema, I. Abe, Y. Asakawa, 2019, Chemistry & biodiversity.

Picrajavanicins H–M, new quassinoids from Picrasma javanica collected in Myanmar and their antiproliferative activities

I. Abe, Y. Asakawa, H. Morita, 2016 .

Picrajavanicins A-G, Quassinoids from Picrasma javanica Collected in Myanmar.

I. Abe, Y. Asakawa, H. Morita, 2015, Journal of natural products.

Kaempulchraols P-T, Diterpenoids from Kaempferia pulchra Rhizomes Collected in Myanmar.

I. Abe, Y. Asakawa, H. Morita, 2015, Journal of natural products.

Probing biosynthesis of plant polyketides with synthetic N-acetylcysteamine thioesters.

I. Abe, H. Noguchi, S. Ayabe, 2004, Biochemical and biophysical research communications.

Engineered biosynthesis of plant polyketides: chain length control in an octaketide-producing plant type III polyketide synthase.

I. Abe, H. Noguchi, S. Oguro, 2005, Journal of the American Chemical Society.

Enzymatic formation of quinolone alkaloids by a plant type III polyketide synthase.

I. Abe, H. Noguchi, Kiyofumi Wanibuchi, 2006, Organic letters.

Enzymatic formation of unnatural novel chalcone, stilbene, and benzophenone scaffolds by plant type III polyketide synthase.

I. Abe, H. Noguchi, H. Morita, 2009, Organic letters.

Novel type III polyketide synthases from Aloe arborescens

I. Abe, H. Noguchi, H. Morita, 2009, The FEBS journal.

An acridone‐producing novel multifunctional type III polyketide synthase from Huperzia serrata

I. Abe, H. Noguchi, T. Kohno, 2007, The FEBS journal.

Biosynthetic pathway for high structural diversity of a common dilactone core in antimycin production.

I. Abe, Y. Asakawa, Wen Liu, 2012, Organic letters.

Unique chemistry of non-heme iron enzymes in fungal biosynthetic pathways.

I. Abe, Hitomi Nakamura, Yudai Matsuda, 2018, Natural product reports.

Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage

I. Abe, X. Yao, Gao-qian Wang, 2018, Nature Communications.

An Unusual Chimeric Diterpene Synthase from Emericella variecolor and Its Functional Conversion into a Sesterterpene Synthase by Domain Swapping.

I. Abe, T. Wakimoto, Takahiro Mori, 2016, Angewandte Chemie.

Astellifadiene: Structure Determination by NMR Spectroscopy and Crystalline Sponge Method, and Elucidation of its Biosynthesis.

I. Abe, M. Fujita, Shoukou Lee, 2016, Angewandte Chemie.

An environmental bacterial taxon with a large and distinct metabolic repertoire

Christian Rinke, Kentaro Takada, Christian Rückert, 2014, Nature.

Identification of Pyridinium with Three Indole Moieties as an Antimicrobial Agent.

I. Abe, T. Wakimoto, M. Okada, 2017, Journal of natural products.

Corrigendum: An environmental bacterial taxon with a large and distinct metabolic repertoire

Micheal C. Wilson, J. Kalinowski, Christian Rinke, 2014, Nature.

Biosynthesis of alkyne-containing natural products

I. Abe, Dan Hu, Jianming Lv, 2020, RSC chemical biology.

Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution

J. Hashimoto, I. Kozone, H. Ikeda, 2018, Nature Communications.

Computational Studies on Biosynthetic Carbocation Rearrangements Leading to Quiannulatene: Initial Conformation Regulates Biosynthetic Route, Stereochemistry, and Skeleton Type.

I. Abe, M. Yamazaki, M. Uchiyama, 2018, Angewandte Chemie.

Computational Studies on Biosynthetic Carbocation Rearrangements Leading to Quiannulatene: Initial Conformation Regulates Biosynthetic Route, Stereochemistry, and Skeleton Type

I. Abe, M. Yamazaki, M. Uchiyama, 2018, Angewandte Chemie.

Lanosterol synthase mutations cause cholesterol deficiency-associated cataracts in the Shumiya cataract rat.

T. Serikawa, I. Abe, Zhanjun Guo, 2006, The Journal of clinical investigation.

Porphyrins from a metagenomic library of the marine sponge Discodermia calyx.

I. Abe, Bochu Wang, Y. Asakawa, 2012, Molecular bioSystems.

3,5-Dimethylorsellinic Acid Derived Meroterpenoids from Penicillium chrysogenum MT-12, an Endophytic Fungus Isolated from Huperzia serrata.

I. Abe, Kewu Zeng, Juan Wang, 2017, Journal of natural products.

Biosynthesis of the teleocidin-type terpenoid indole alkaloids.

I. Abe, T. Awakawa, 2018, Organic & biomolecular chemistry.

Aminoacyl sulfonamide assembly in SB-203208 biosynthesis

I. Abe, Zhongjun Ma, T. Awakawa, 2019, Nature Communications.

Identification and characterization of N9-methyltransferase involved in converting caffeine into non-stimulatory theacrine in tea

I. Abe, Xiaoyun Lu, R. He, 2020, Nature Communications.

Structure and Function of the Chalcone Synthase Superfamily of Plant Type III Polyketide Synthases

I. Abe, H. Morita, 2010 .

Combinatorial Biosynthesis of (+)-Daurichromenic Acid and Its Halogenated Analogue.

I. Abe, F. Taura, T. Awakawa, 2017, Organic letters.

Cycloforskamide, a cytotoxic macrocyclic peptide from the sea slug Pleurobranchus forskalii.

I. Abe, T. Ohtsuki, T. Wakimoto, 2013, Journal of natural products.

Molecular basis for the unusual ring reconstruction in fungal meroterpenoid biogenesis.

I. Abe, Takahiro Mori, Hang Wang, 2017, Nature chemical biology.

Expression, purification and crystallization of an indole prenyltransferase from Aspergillus fumigatus.

I. Abe, H. Noguchi, R. Kato, 2012, Acta crystallographica. Section F, Structural biology and crystallization communications.

Crystallization and preliminary X-ray analysis of 4-coumarate:CoA ligase from Arabidopsis thaliana.

I. Abe, R. Kato, H. Morita, 2011, Acta crystallographica. Section F, Structural biology and crystallization communications.

Expression, purification and crystallization of a plant type III polyketide synthase that produces diarylheptanoids.

I. Abe, R. Kato, H. Morita, 2010, Acta crystallographica. Section F, Structural biology and crystallization communications.

Engineering of Candida glabrata Ketoreductase 1 for Asymmetric Reduction of α-Halo Ketones

I. Abe, Takahiro Mori, Bin Qin, 2016 .

Chemistry of fungal meroterpenoid cyclases.

I. Abe, Lena Barra, 2020, Natural product reports.

Biosynthesis of fungal meroterpenoids.

I. Abe, Yudai Matsuda, 2016, Natural product reports.

Dietziamides, novel tetramic acid dimers from Dietzia timorensis MZ-3 with antioxidative activity.

I. Abe, T. Wakimoto, Shotaro Hoshino, 2015, Bioorganic & medicinal chemistry letters.

Biosynthesis of helvolic acid and identification of an unusual C-4-demethylation process distinct from sterol biosynthesis

I. Abe, X. Yao, Guo-dong Chen, 2017, Nature Communications.

Multiplexing of combinatorial chemistry in antimycin biosynthesis: expansion of molecular diversity and utility.

J. Chen, I. Abe, Daozhong Zhang, 2013, Angewandte Chemie.

Molecular basis for the plasticity of aromatic prenyltransferases in hapalindole biosynthesis

I. Abe, T. Awakawa, 2019, Beilstein journal of organic chemistry.

Expression, purification and crystallization of a fungal type III polyketide synthase that produces the csypyrones.

I. Abe, M. Hashimoto, T. Matsui, 2014, Acta crystallographica. Section F, Structural biology communications.

Crystallization and preliminary X-ray diffraction analysis of AntE, a crotonyl-CoA carboxylase/reductase from Streptomyces sp. NRRL 2288.

J. Chen, I. Abe, Wen Liu, 2014, Acta crystallographica. Section F, Structural biology communications.

Crystallization and preliminary crystallographic analysis of a plant type III polyketide synthase that produces benzalacetone.

I. Abe, H. Noguchi, M. Tanio, 2008, Acta crystallographica. Section F, Structural biology and crystallization communications.

Crystallization and preliminary crystallographic analysis of an octaketide-producing plant type III polyketide synthase.

I. Abe, H. Noguchi, S. Kondo, 2007, Acta crystallographica. Section F, Structural biology and crystallization communications.

Crystallization and preliminary crystallographic analysis of an acridone-producing novel multifunctional type III polyketide synthase from Huperzia serrata.

I. Abe, H. Noguchi, S. Kondo, 2007, Acta crystallographica. Section F, Structural biology and crystallization communications.

Crystallization and preliminary crystallographic analysis of a novel plant type III polyketide synthase that produces pentaketide chromone.

I. Abe, H. Noguchi, S. Kondo, 2006, Acta crystallographica. Section F, Structural biology and crystallization communications.

Engineered biosynthesis of plant polyketides: structure-based and precursor-directed approach.

I. Abe, 2010, Topics in current chemistry.

Noncanonical Functions of Enzyme Cofactors as Building Blocks in Natural Product Biosynthesis

I. Abe, T. Awakawa, Lena Barra, 2022, JACS Au.

Novel polyketides synthesized with a higher plant stilbene synthase.

I. Abe, H. Noguchi, H. Morita, 2001, European journal of biochemistry.

Discovery of non-squalene triterpenes

Jeroen S. Dickschat, I. Abe, Tiangang Liu, 2022, Nature.

Reconstituted biosynthesis of fungal meroterpenoid andrastin A

I. Abe, T. Awakawa, Yudai Matsuda, 2013 .

Structural basis for endoperoxide-forming oxygenases

I. Abe, Takahiro Mori, 2022, Beilstein journal of organic chemistry.

Phosphocalyculin C as a pyrophosphate protoxin of calyculin C in the marine sponge Discodermia calyx.

I. Abe, T. Wakimoto, Yoko Egami, 2014, Bioorganic & medicinal chemistry letters.

Allos-hemicalyculin A, a photochemically converted calyculin from the marine sponge Discodermia calyx

I. Abe, T. Wakimoto, Mikihiko Kimura, 2013 .

Enzymology and biosynthesis of the orsellinic acid derived medicinal meroterpenoids.

I. Abe, Hui-Wen Tao, 2020, Current opinion in biotechnology.

Intermolecular [4+2]-cycloaddition reaction to biotransform morachalcone A into kuwanon J, catalyzed by Diels-Alderase from a root culture of Morus alba var. shalun ( M. shalun )

I. Abe, R. Hertadi, H. Morita, 2020 .

Novofumigatonin biosynthesis involves a non-heme iron-dependent endoperoxide isomerase for orthoester formation

M. Andersen, I. Abe, U. Mortensen, 2018, Nature Communications.

Biosynthesis of medicinally important plant metabolites by unusual type III polyketide synthases

I. Abe, 2020, Journal of Natural Medicines.

Sulfoureido Lipopeptides from the Marine Sponge Discodermia kiiensis.

I. Abe, T. Wakimoto, K. Tan, 2016, Journal of natural products.

Biosynthesis: An HR-PKS stereo surprise.

I. Abe, 2012, Nature chemical biology.

Arcyriaflavin E, a new cytotoxic indolocarbazole alkaloid isolated by combined-culture of mycolic acid-containing bacteria and Streptomyces cinnamoneus NBRC 13823

I. Abe, T. Wakimoto, H. Onaka, 2014, The Journal of Antibiotics.

Identification of the active site of vertebrate oxidosqualene cyclase

G. Prestwich, I. Abe, 1995, Lipids.

Active site mapping of affinity-labeled rat oxidosqualene cyclase.

G. Prestwich, I. Abe, 1994, The Journal of biological chemistry.

Anti-Vpr activities of sesqui- and diterpenoids from the roots and rhizomes of Kaempferia candida

Prema, I. Abe, H. Morita, 2021, Journal of Natural Medicines.

Calyxamides A and B, cytotoxic cyclic peptides from the marine sponge Discodermia calyx.

I. Abe, T. Wakimoto, Yoko Egami, 2012, Journal of natural products.

Umezawamides, new bioactive polycyclic tetramate macrolactams isolated from a combined-culture of Umezawaea sp. and mycolic acid-containing bacterium

I. Abe, H. Onaka, Shumpei Asamizu, 2018, The Journal of Antibiotics.

Structural Basis for Isomerization Reactions in Fungal Tetrahydroxanthone Biosynthesis and Diversification

I. Abe, Takahiro Mori, Jiali Yang, 2021, Angewandte Chemie.

Structural basis for isomerization reactions in fungal tetrahydroxanthone biosynthesis and diversification.

I. Abe, Takahiro Mori, Jiali Yang, 2021, Angewandte Chemie.

Exploiting a C–N Bond Forming Cytochrome P450 Monooxygenase for C–S Bond Formation

I. Abe, M. Fujita, T. Ohwada, 2020, Angewandte Chemie.

Exploiting a C-N bond forming cytochrome P450 monooxygenase for C-S bond formation.

I. Abe, M. Fujita, T. Ohwada, 2019, Angewandte Chemie.

Structural Elucidation of Tenebrathin: Cytotoxic C-5-Substituted γ-Pyrone with a Nitroaryl Side Chain from Streptoalloteichus tenebrarius.

I. Abe, M. Fujita, H. Morita, 2019, Organic letters.

Crystalline Sponge Method Enabled the Investigation of a Prenyltransferase-terpene Synthase Chimeric Enzyme, Whose Product Exhibits Broadened NMR Signals.

I. Abe, M. Fujita, Shepo Shi, 2018, Organic letters.

Complete biosynthetic pathways of ascofuranone and ascochlorin in Acremonium egyptiacum

I. Abe, T. Awakawa, K. Kita, 2019, Proceedings of the National Academy of Sciences.

Unusual Dioxygen-Dependent Reactions Catalyzed by Nonheme Iron Enzymes in Natural Product Biosynthesis

I. Abe, Richiro Ushimaru, 2022, ACS Catalysis.

Biosynthesis of Biscognienyne B Involving a Cytochrome P450‐Dependent Alkynylation

I. Abe, X. Yao, Huan Zhao, 2020 .

Biosynthesis of biscognienyne B involving an unprecedented cytochrome P450-dependent alkynylation.

I. Abe, X. Yao, Huan Zhao, 2020, Angewandte Chemie.

Identification and Characterization of Daurichromenic Acid Synthase Active in Anti-HIV Biosynthesis1

I. Abe, F. Taura, Y. Asakawa, 2017, Plant Physiology.

Activation of silent biosynthetic pathways and discovery of novel secondary metabolites in actinomycetes by co-culture with mycolic acid-containing bacteria

I. Abe, H. Onaka, Shotaro Hoshino, 2019, Journal of Industrial Microbiology & Biotechnology.

Benzophenone synthase from Garcinia mangostana L. pericarps.

I. Abe, H. Morita, Y. Ebizuka, 2012, Phytochemistry.

Complete biosynthetic pathway of anditomin: nature's sophisticated synthetic route to a complex fungal meroterpenoid.

I. Abe, T. Wakimoto, Takahiro Mori, 2014, Journal of the American Chemical Society.

2-Alkylquinolone alkaloid biosynthesis in the medicinal plant Evodia rutaecarpa involves collaboration of two novel type III polyketide synthases

I. Abe, H. Noguchi, T. Matsui, 2017, The Journal of Biological Chemistry.

Cloning and Structure-Function Analyses of Quinolone- and Acridone-producing Novel Type III Polyketide Synthases from Citrus microcarpa*

I. Abe, H. Noguchi, T. Matsui, 2013, The Journal of Biological Chemistry.

Benzalacetone Synthase

I. Abe, H. Morita, Y. Shimokawa, 2012, Front. Plant Sci..

Engineering of plant polyketide biosynthesis.

I. Abe, 2008, Chemical & pharmaceutical bulletin.

Furan fatty acid as an anti-inflammatory component from the green-lipped mussel Perna canaliculus

I. Abe, T. Asakawa, T. Kan, 2011, Proceedings of the National Academy of Sciences.

Viral protein R inhibitors from Swertia chirata of Myanmar.

I. Abe, H. Morita, Takuya Ito, 2019, Journal of bioscience and bioengineering.

Cytotoxic Cyclic Peptides from the Marine Sponges

I. Abe, T. Wakimoto, K. Tan, 2015 .

Lipodiscamides A-C, new cytotoxic lipopeptides from Discodermia kiiensis.

I. Abe, T. Wakimoto, K. Tan, 2014, Organic letters.

Biomimetic Synthesis of Meroterpenoids by Dearomatization- Driven Polycyclization.

I. Abe, M. Fujita, J. Porco, 2019, Angewandte Chemie.

Biosynthesis of dihydroxyardeemin by heterologous expression

I. Abe, T. Awakawa, Lu Zhou, 2022, Tetrahedron.

Manipulation of prenylation reactions by structure-based engineering of bacterial indolactam prenyltransferases

I. Abe, H. Morita, Takahiro Mori, 2016, Nature Communications.

Structural Basis for β-Carboline Alkaloid Production by the Microbial Homodimeric Enzyme McbB.

I. Abe, T. Matsui, T. Wakimoto, 2015, Chemistry & biology.

Pyranonigrin E: A PKS‐NRPS Hybrid Metabolite from Aspergillus niger Identified by Genome Mining

I. Abe, T. Wakimoto, T. Awakawa, 2013, Chembiochem : a European journal of chemical biology.

A methyltransferase initiates terpene cyclization in teleocidin B biosynthesis.

I. Abe, T. Wakimoto, J. Ishikawa, 2014, Journal of the American Chemical Society.

β-NAD as a building block in natural product biosynthesis

I. Abe, T. Awakawa, G. Bashiri, 2021, Nature.

Stereoselectivity and Substrate Specificity of the Fe(II)/α-Ketoglutarate-Dependent Oxygenase TqaL.

I. Abe, Takahiro Mori, T. Awakawa, 2022, Journal of the American Chemical Society.

Oxidative modification of free-standing amino acids by Fe(II)/αKG-dependent oxygenases

I. Abe, Hui-Wen Tao, 2022, Engineering Microbiology.

Two Distinct Substrate Binding Modes for the Normal and Reverse Prenylation of Hapalindoles by the Prenyltransferase AmbP3.

I. Abe, Xinyu Liu, Y. Nakashima, 2018, Angewandte Chemie.

Reconstitution of a fungal meroterpenoid biosynthesis reveals the involvement of a novel family of terpene cyclases.

Takayuki Itoh, Ikuro Abe, Isao Fujii, 2010, Nature chemistry.

Stereodivergent Nitrocyclopropane Formation during Biosynthesis of Belactosins and Hormaomycins.

I. Abe, K. Miyamoto, Leonard Kaysser, 2021, Journal of the American Chemical Society.

Aziridine Formation by a Fe II /α‐Ketoglutarate Dependent Oxygenase and 2‐Aminoisobutyrate Biosynthesis in Fungi

I. Abe, Takahiro Mori, T. Awakawa, 2021, Angewandte Chemie.

Harnessing Fe(II)/α-ketoglutarate-dependent oxygenases for structural diversification of fungal meroterpenoids.

I. Abe, Hui Tao, 2022, Current opinion in biotechnology.

Structure-based engineering of α-ketoglutarate dependent oxygenases in fungal meroterpenoid biosynthesis.

I. Abe, Takahiro Mori, T. Awakawa, 2022, Natural product reports.

Molecular insights into the unusually promiscuous and catalytically versatile Fe(II)/α-ketoglutarate-dependent oxygenase SptF

I. Abe, Shoukou Lee, Takahiro Mori, 2021, Nature communications.

Heterodimeric Non-heme Iron Enzymes in Fungal Meroterpenoid Biosynthesis.

I. Abe, Bin Wu, Takahiro Mori, 2021, Journal of the American Chemical Society.

Molecular insights into the endoperoxide formation by Fe(II)/α-KG-dependent oxygenase NvfI

I. Abe, R. Zhai, Takahiro Mori, 2021, Nature Communications.

Aziridine formation by a Fe(II)/α-ketoglutarate dependent oxygenase and 2-aminoisobutyrate biosynthesis in fungi.

I. Abe, Takahiro Mori, T. Awakawa, 2021, Angewandte Chemie.

Fungal Meroterpenoids

I. Abe, Yudai Matsuda, 2020, Comprehensive Natural Products III.

Structure function and engineering of multifunctional non-heme iron dependent oxygenases in fungal meroterpenoid biosynthesis

I. Abe, Y. Nakashima, Takahiro Mori, 2018, Nature Communications.

Orthoester formation in fungal meroterpenoid austalide F biosynthesis

I. Abe, T. Awakawa, Wei Liu, 2023, Philosophical Transactions of the Royal Society B.

Kaempulchraols I–O: new isopimarane diterpenoids from Kaempferia pulchra rhizomes collected in Myanmar and their antiproliferative activity

I. Abe, Y. Asakawa, H. Morita, 2015 .

Kaempulchraols A-H, Diterpenoids from the Rhizomes of Kaempferia pulchra Collected in Myanmar.

I. Abe, H. Morita, H. Imagawa, 2015, Journal of natural products.

Labdane diterpenoids from Curcuma amada rhizomes collected in Myanmar and their antiproliferative activities.

Prema, I. Abe, Y. Asakawa, 2017, Fitoterapia.

Purification of squalene‐2,3‐epoxide cyclases from cell suspension cultures of Rabdosia japonica Hara

I. Abe, U. Sankawa, Y. Ebizuka, 1989 .

Antioxidative galloyl esters as enzyme inhibitors of p‐hydroxybenzoate hydroxylase

I. Abe, H. Noguchi, K. Kashiwagi, 2000, FEBS letters.

Potent and selective inhibition of squalene epoxidase by synthetic galloyl esters.

I. Abe, T. Seki, H. Noguchi, 2000, Biochemical and biophysical research communications.

Enzymatic synthesis of cyclic triterpenes.

I. Abe, 2007, Natural product reports.

Anti-Vpr activities of homodrimane sesquiterpenoids and labdane diterpenoids from Globba sherwoodiana rhizomes.

Prema, I. Abe, H. Morita, 2020, Fitoterapia.

Tetrahydrofuran lignans: Melanogenesis inhibitors from Premna integrifolia wood collected in Myanmar.

Prema, I. Abe, Y. Asakawa, 2018, Fitoterapia.

Quassinoids: Viral protein R inhibitors from Picrasma javanica bark collected in Myanmar for HIV infection.

I. Abe, H. Morita, Takuya Ito, 2016, Bioorganic & medicinal chemistry letters.

Isopimarane diterpenoids from Kaempferia pulchra rhizomes collected in Myanmar and their Vpr inhibitory activity.

I. Abe, T. Matsui, Y. Asakawa, 2016, Bioorganic & medicinal chemistry letters.

Bis-iridoid and iridoid glycosides: Viral protein R inhibitors from Picrorhiza kurroa collected in Myanmar.

I. Abe, H. Morita, N. Win, 2019, Fitoterapia.

Very-long-chain 3-hydroxy fatty acids, 3-hydroxy fatty acid methyl esters and 2-alkanols from cuticular waxes of Aloe arborescens leaves.

I. Abe, R. Jetter, T. Awakawa, 2015, Phytochemistry.

Cytotoxic tetramic acid derivative produced by a plant type-III polyketide synthase.

I. Abe, T. Wakimoto, H. Morita, 2011, Journal of the American Chemical Society.

Enzymatic Cyclization of 22,23-Dihydro-2,3-oxidosqualene into Euph-7-en-3β-ol and Bacchar-12-en-3β-ol by Recombinant β-Amyrin Synthase

I. Abe, H. Noguchi, Y. Ebizuka, 2004 .

Lignans with melanogenesis effects from Premna serratifolia wood.

Prema, I. Abe, H. Morita, 2019, Fitoterapia.

A New Tetrahydrofuran Lignan from Premna serratifolia Wood

Prema, I. Abe, H. Morita, 2019, Natural Product Communications.

Synthesis of unnatural alkaloid scaffolds by exploiting plant polyketide synthase

Ryohei Kato, Toshiyuki Kohno, Hiroyuki Morita, 2011, Proceedings of the National Academy of Sciences.

Inhibitors of squalene biosynthesis and metabolism.

G. Prestwich, I. Abe, J. Tomesch, 1994, Natural product reports.

Biosynthesis of LL‐Z1272β: Discovery of a New Member of NRPS‐like Enzymes for Aryl‐Aldehyde Formation

I. Abe, X. Yao, Hao Gao, 2016, Chembiochem : a European journal of chemical biology.

Enzymic cyclization of 2,3-dihydrosqualene and squalene 2,3-epoxide by squalene cyclases: from pentacyclic to tetracyclic triterpenes

I. Abe, M. Rohmer, 1994 .

(+)- and (-)-Preuisolactone A: A Pair of Caged Norsesquiterpenoidal Enantiomers with a Tricyclo[4.4.01,6.02,8]decane Carbon Skeleton from the Endophytic Fungus Preussia isomera.

I. Abe, Xiao-Long Yang, Yuan Gao, 2019, Organic letters.

Enzymatic Synthesis of Unnatural Cyclic Triterpenes

I. Abe, 2012 .

[Engineering of squalene cyclizing enzymes].

I. Abe, 2008, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Enzymatic formation of unnatural cytokinin analogs by adenylate isopentenyltransferase from mulberry.

I. Abe, H. Noguchi, T. Abe, 2007, Biochemical and biophysical research communications.

Microbial soluble aromatic prenyltransferases for engineered biosynthesis

I. Abe, Heping Chen, 2021, Synthetic and systems biotechnology.

Posttranslational isoprenylation of tryptophan in bacteria

I. Abe, M. Okada, Tomotoshi Sugita, 2017, Beilstein journal of organic chemistry.

Stereospecific prenylation of tryptophan by a cyanobacterial post-translational modification enzyme.

I. Abe, Y. Nakashima, Takahiro Mori, 2016, Organic & biomolecular chemistry.

Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage

I. Abe, X. Yao, Gao-qian Wang, 2018, Nature Communications.

Biosynthesis of helvolic acid and identification of an unusual C-4-demethylation process distinct from sterol biosynthesis

I. Abe, X. Yao, Guo-dong Chen, 2017, Nature Communications.

Induced production of mycotoxins in an endophytic fungus from the medicinal plant Datura stramonium L.

I. Abe, H. Noguchi, T. Awakawa, 2012, Bioorganic & medicinal chemistry letters.

Induced biosyntheses of a novel butyrophenone and two aromatic polyketides in the plant pathogen Stagonospora nodorum

I. Abe, T. Wakimoto, T. Awakawa, 2013, Natural Products and Bioprospecting.

A heptaketide naphthaldehyde produced by a polyketide synthase from Nectria haematococca.

I. Abe, T. Wakimoto, T. Kaji, 2012, Bioorganic & medicinal chemistry letters.

Catenulobactins A and B, Heterocyclic Peptides from Culturing Catenuloplanes sp. with a Mycolic Acid-Containing Bacterium.

I. Abe, H. Onaka, H. Morita, 2018, Journal of natural products.

Uncovering the unusual D-ring construction in terretonin biosynthesis by collaboration of a multifunctional cytochrome P450 and a unique isomerase.

I. Abe, T. Wakimoto, T. Awakawa, 2015, Journal of the American Chemical Society.

Prenylation of a nonaromatic carbon of indolylbutenone by a fungal indole prenyltransferase.

I. Abe, H. Noguchi, T. Wakimoto, 2012, Organic letters.

Cytochrome P450 for Citreohybridonol Synthesis: Oxidative Derivatization of the Andrastin Scaffold.

I. Abe, Yudai Matsuda, Zhiyang Quan, 2016, Organic letters.

Spiro-ring formation is catalyzed by a multifunctional dioxygenase in austinol biosynthesis.

I. Abe, T. Wakimoto, T. Awakawa, 2013, Journal of the American Chemical Society.

Induced production of novel prenyldepside and coumarins in endophytic fungi Pestalotiopsis acaciae

I. Abe, T. Wakimoto, T. Awakawa, 2013 .

Epigenetic modifier-induced biosynthesis of novel fusaric acid derivatives in endophytic fungi from Datura stramonium L.

I. Abe, T. Wakimoto, T. Awakawa, 2013, Natural Products and Bioprospecting.

Sporormielones A-E, bioactive novel C-C coupled orsellinic acid derivative dimers, and their biosynthetic origin.

I. Abe, X. Yao, Guo-dong Chen, 2020, Chemical communications.

Cyclodipeptides from metagenomic library of a japanese marine sponge

I. Abe, Bochu Wang, T. Wakimoto, 2013 .

A plant type III polyketide synthase that produces pentaketide chromone.

I. Abe, H. Noguchi, H. Morita, 2005, Journal of the American Chemical Society.

Multidomain P450 Epoxidase and a Terpene Cyclase from the Ascochlorin Biosynthetic Pathway in Fusarium sp.

I. Abe, T. Awakawa, Yue Hu, 2019, Organic letters.

Molecular cloning and characterization of copper amine oxidase from Huperzia serrata.

I. Abe, H. Noguchi, H. Morita, 2012, Bioorganic & medicinal chemistry letters.

A New Monoterpene from the Rhizomes of Alpinia galanga and Its Anti‐Vpr Activity

Prema, I. Abe, H. Morita, 2021, Chemistry & biodiversity.

Ergot alkaloid from the sea slug Pleurobranchus forskalii.

I. Abe, T. Wakimoto, K. Tan, 2013, Toxicon : official journal of the International Society on Toxinology.

The first plant type III polyketide synthase that catalyzes formation of aromatic heptaketide

I. Abe, H. Noguchi, S. Oguro, 2004, FEBS letters.

Enzymatic formation of unnatural novel polyketides from alternate starter and nonphysiological extension substrate by chalcone synthase.

I. Abe, H. Noguchi, Yusuke Takahashi, 2003, Organic letters.

Engineering of plant type III polyketide synthases.

I. Abe, T. Wakimoto, H. Morita, 2012, Methods in enzymology.

Enzymatic formation of an aromatic dodecaketide by engineered plant polyketide synthase.

Hiroyuki Morita, Ikuro Abe, Hiroshi Noguchi, 2011, Bioorganic & medicinal chemistry letters.

Molecular Cloning, Modeling, and Site-Directed Mutagenesis of Type III Polyketide Synthase from Sargassum binderi (Phaeophyta)

I. Abe, C. Ho, H. Morita, 2011, Marine Biotechnology.

Structural insight into chain-length control and product specificity of pentaketide chromone synthase from Aloe arborescens.

I. Abe, H. Noguchi, S. Kondo, 2007, Chemistry & biology.

Substrate Specificity of Chalcone Synthase: Enzymatic Formation of Unnatural Polyketides from Synthetic Cinnamoyl-CoA Analogues

I. Abe, H. Noguchi, H. Morita, 2000 .

Plant Type III PKS

I. Abe, H. Noguchi, H. Morita, 2010 .

Black Tea Theaflavins Are Potent Inhibitors of Squalene Epoxidase, A Key Enzyme in Cholesterol Biosynthesis

I. Abe, T. Seki, H. Noguchi, 2000 .

Analysis of agaritine in mushrooms and in agaritine-administered mice using liquid chromatography-tandem mass spectrometry.

I. Abe, H. Akiyama, K. Kondo, 2006, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Determination of genotoxic phenylhydrazine agaritine in mushrooms using liquid chromatography–electrospray ionization tandem mass spectrometry

I. Abe, H. Akiyama, K. Kondo, 2006, Food additives and contaminants.

Two new pyrrolo-2-aminoimidazoles from a Myanmarese marine sponge, Clathria prolifera

I. Abe, H. Morita, Takuya Ito, 2018, Journal of Natural Medicines.

Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase.

I. Abe, H. Noguchi, Y. Kashiwagi, 2001, Journal of natural products.

Terretonin Biosynthesis Requires Methylation as Essential Step for Cyclization

I. Abe, T. Wakimoto, Y. Ebizuka, 2012, Chembiochem : a European journal of chemical biology.

Shanpanootols A-F, diterpenoids from Kaempferia pulchra rhizomes collected in Myanmar and their Vpr inhibitory activities.

I. Abe, H. Morita, Saw Yu Yu Hnin, 2021, Fitoterapia.

Discovery of Key Dioxygenases that Diverged the Paraherquonin and Acetoxydehydroaustin Pathways in Penicillium brasilianum.

I. Abe, Y. Nakashima, Takahiro Mori, 2016, Journal of the American Chemical Society.

Structural Diversification of Andiconin-Derived Natural Products by α-Ketoglutarate-Dependent Dioxygenases.

I. Abe, Yonghui Zhang, Takahiro Mori, 2020, Organic letters.

A Multifunctional Cytochrome P450 and a Meroterpenoid Cyclase in the Biosynthesis of Fungal Meroterpenoid Atlantinone B.

I. Abe, P. Tu, Jun Li, 2022, Organic letters.

Reconstitution of Polyketide-Derived Meroterpenoid Biosynthetic Pathway in Aspergillus oryzae

I. Abe, T. Awakawa, 2021, Journal of fungi.

Exploiting the Potential of Meroterpenoid Cyclases to Expand the Chemical Space of Fungal Meroterpenoids.

I. Abe, M. Fujita, J. Porco, 2020, Angewandte Chemie.

Fe(II)/(Alpha)Ketoglutarate-Dependent Dioxygenase PrhA

I. Abe, Takahiro Mori, 2019, Encyclopedia of Inorganic and Bioinorganic Chemistry.

Unusual chemistries in fungal meroterpenoid biosynthesis.

I. Abe, Takahiro Mori, T. Awakawa, 2016, Current opinion in chemical biology.

Identification of a Key Prenyltransferase Involved in Biosynthesis of the Most Abundant Fungal Meroterpenoids Derived from 3,5‐Dimethylorsellinic Acid.

I. Abe, E. Radhakrishnan, Y. Ebizuka, 2012, Chembiochem : a European journal of chemical biology.

C-Glycoside metabolism in the gut and in nature: Identification, characterization, structural analyses and distribution of C-C bond-cleaving enzymes

I. Abe, M. Kawasaki, T. Kumano, 2021, Nature Communications.

Cordycicadins A-D, Antifeedant Polyketides from the Entomopathogenic Fungus Cordyceps cicadae JXCH1.

I. Abe, Jikai Liu, Takahiro Mori, 2022, Organic letters.

Benzalacetone synthase. A novel polyketide synthase that plays a crucial role in the biosynthesis of phenylbutanones in Rheum palmatum.

I. Abe, H. Noguchi, Y. Takahashi, 2001, European journal of biochemistry.

Naturally occurring Vpr inhibitors from medicinal plants of Myanmar

I. Abe, H. Morita, N. Win, 2017, Journal of Natural Medicines.

Site-directed mutagenesis of conserved aromatic residues in rat squalene epoxidase.

I. Abe, H. Noguchi, T. Masuoka, 2007, Biochemical and biophysical research communications.

Enyzmatic cyclization of 2,3-dihydrosqualene into euph-7-ene by a cell-free system from the protozoon Tetrahymena pyriformis

I. Abe, M. Rohmer, 1991 .

Molecular cloning, expression, and site-directed mutations of oxidosqualene cyclase from Cephalosporium caerulens.

I. Abe, H. Noguchi, Y. Takagi, 2001, Biochimica et biophysica acta.

Molecular cloning, characterization, and functional expression of rat oxidosqualene cyclase cDNA.

G. Prestwich, I. Abe, Glenn D. Prestwich, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Affinity labeling of vertebrate oxidosqualene cyclases with a tritiated suicide substrate.

G. Prestwich, I. Abe, M. Bai, 1992, Biochemical and biophysical research communications.

Molecular Basis for Stellatic Acid Biosynthesis: A Genome Mining Approach for Discovery of Sesterterpene Synthases.

I. Abe, Yudai Matsuda, Zhiyang Quan, 2015, Organic letters.

Molecular Basis for Sesterterpene Diversity Produced by Plant Terpene Synthases

I. Abe, Guodong Wang, Jianxu Li, 2020, Plant communications.

Sesterterpenoids.

I. Abe, Takaaki Mitsuhashi, 2020, Progress in the chemistry of organic natural products.

Characterization of Giant Modular PKSs Provides Insight into Genetic Mechanism for Structural Diversification of Aminopolyol Polyketides.

Junko Hashimoto, Shunji Takahashi, Hiroyuki Osada, 2017, Angewandte Chemie.

Galloyl esters from rhubarb are potent inhibitors of squalene epoxidase, a key enzyme in cholesterol biosynthesis.

I. Abe, T. Seki, H. Noguchi, 2000, Planta medica.

Enzymatic formation of unnatural aromatic polyketides by chalcone synthase.

I. Abe, H. Noguchi, Y. Takahashi, 2000, Biochemical and biophysical research communications.

Identification of a diarylpentanoid-producing polyketide synthase revealing an unusual biosynthetic pathway of 2-(2-phenylethyl)chromones in agarwood

I. Abe, P. Tu, H. Morita, 2022, Nature Communications.

Identification of a diarylpentanoid-producing polyketide synthase revealing an unusual biosynthetic pathway of 2-(2-phenylethyl)chromones in agarwood

I. Abe, P. Tu, H. Morita, 2022, Nature Communications.

Structural basis for the one-pot formation of the diarylheptanoid scaffold by curcuminoid synthase from Oryza sativa

I. Abe, R. Kato, H. Morita, 2010, Proceedings of the National Academy of Sciences.

Structural Insight into the Enzymatic Formation of Bacterial Stilbene.

I. Abe, H. Morita, Takahiro Mori, 2016, Cell chemical biology.

FK506 Maturation Involves a Cytochrome P450 Protein-Catalyzed Four-Electron C-9 Oxidation in Parallel with a C-31 O-Methylation

I. Abe, Zhinan Xu, Wen Liu, 2013, Journal of bacteriology.

Revised structure of cyclolithistide A, a cyclic depsipeptide from the marine sponge Discodermia japonica.

I. Abe, T. Wakimoto, Kentaro Takada, 2014, Journal of natural products.

Indole-porphyrin hybrids produced by metagenomics.

I. Abe, T. Wakimoto, Yoko Egami, 2013, Bioorganic & Medicinal Chemistry Letters.

Enzymatic formation of indolactam scaffold by C-N bond-forming cytochrome P450 oxidases in teleocidin biosynthesis.

I. Abe, Takahiro Mori, Iori Morita, 2020, Chemistry.

Production of indole antibiotics induced by exogenous gene derived from sponge metagenomes.

I. Abe, T. Wakimoto, Yoko Egami, 2015, Molecular Biosystems.

Insight into the aroma profile of Bulgarian tobacco absolute oil

I. Abe, L. Antonov, D. Ivanova, 2016 .

Structure function and engineering of multifunctional non-heme iron dependent oxygenases in fungal meroterpenoid biosynthesis

I. Abe, Y. Nakashima, Takahiro Mori, 2018, Nature Communications.

Structure function and engineering of multifunctional non-heme iron dependent oxygenases in fungal meroterpenoid biosynthesis

I. Abe, Y. Nakashima, Takahiro Mori, 2018, Nature Communications.

Mechanistic Characterization of Two Chimeric Sesterterpene Synthases from Penicillium.

Jeroen S. Dickschat, I. Abe, M. Okada, 2017, Chemistry.

Structural Basis for the Formation of Acylalkylpyrones from Two β-Ketoacyl Units by the Fungal Type III Polyketide Synthase CsyB*

I. Abe, M. Hashimoto, T. Matsui, 2015, The Journal of Biological Chemistry.

Insights into phosphatase-activated chemical defense in a marine sponge holobiont

I. Abe, T. Wakimoto, Yoko Egami, 2021, RSC chemical biology.

Niizalactams A-C, Multicyclic Macrolactams Isolated from Combined Culture of Streptomyces with Mycolic Acid-Containing Bacterium.

I. Abe, T. Wakimoto, H. Onaka, 2015, Journal of natural products.

Mycolic Acid Containing Bacterium Stimulates Tandem Cyclization of Polyene Macrolactam in a Lake Sediment Derived Rare Actinomycete.

I. Abe, H. Onaka, Shumpei Asamizu, 2017, Organic letters.

Metagenomic Analysis of the Sponge Discodermia Reveals the Production of the Cyanobacterial Natural Product Kasumigamide by ‘Entotheonella’

I. Abe, T. Wakimoto, Yoko Egami, 2016, PloS one.

Biosynthesis of sulfonamide and sulfamate antibiotics in actinomycete

I. Abe, T. Awakawa, Lena Barra, 2021, Journal of Industrial Microbiology & Biotechnology.

Molecular Insight into the Mg2+ -Dependent Allosteric Control of Indole Prenylation by Aromatic Prenyltransferase AmbP1.

I. Abe, M. L. Hillwig, R. Zhai, 2018, Angewandte Chemie.

Effective Production of Aromatic Polyketides in Streptomyces using a Combined-Culture Method.

I. Abe, H. Onaka, Shotaro Hoshino, 2016, Natural product communications.

Mirilactams C-E, Novel Polycyclic Macrolactams Isolated from Combined-Culture of Actinosynnema mirum NBRC 14064 and Mycolic Acid-Containing Bacterium.

I. Abe, H. Onaka, H. Morita, 2018, Chemical & pharmaceutical bulletin.

Genomic and Spectroscopic Signature-Based Discovery of Natural Macrolactams.

B. Moore, I. Abe, Jeeyeon Lee, 2023, Journal of the American Chemical Society.

Bacterial Squalene Cyclase

I. Abe, 2010 .

Enzymatic formation of pyrrole-containing novel cyclic polyprenoids by bacterial squalene:hopene cyclase

I. Abe, H. Noguchi, H. Noma, 2006 .

Synthesis and enzymatic cyclization of (3S)-14-fluoro-2,3-oxidosqualene

G. Prestwich, I. Abe, B. Robustell, 1998 .

Induced production of the novel glycolipid ustilagic acid C in the plant pathogen Ustilago maydis

I. Abe, T. Wakimoto, T. Awakawa, 2013 .

Discovery of the cryptic function of terpene cyclases as aromatic prenyltransferases

Z. Deng, I. Abe, D. Christianson, 2020, Nature Communications.

Cyclization of (3S)29-Methylidene-2,3-oxidosqualene by Bacterial Squalene:Hopene Cyclase: Irreversible Enzyme Inactivation and Isolation of an Unnatural Dammarenoid

G. Prestwich, K. Poralla, I. Abe, 1997 .

Mechanism-Based Active Site Modification of Oxidosqualene Cyclase by Tritium-Labeled 18-Thia-2,3-Oxidosqualene

G. Prestwich, I. Abe, Wei Liu, 1996 .

Synthesis and Inhibition Studies of Sulfur‐Substituted Squalene Oxide Analogues as Mechanism‐Based Inhibitors of 2,3‐Oxidosqualene‐ Lanosterol Cyclase.

G. Prestwich, I. Abe, Alice L. Perez, 1997 .

Synthesis and inhibition studies of sulfur-substituted squalene oxide analogues as mechanism-based inhibitors of 2,3-oxidosqualene-lanosterol cyclase.

G. Prestwich, I. Abe, P. Hartman, 1997, Journal of medicinal chemistry.

Mechanism-based inhibitors and other active-site targeted inhibitors of oxidosqualene cyclase and squalene cyclase.

G. Prestwich, I. Abe, Y. Zheng, 1998, Journal of enzyme inhibition.

Purification and Properties of Squalene-2, 3-epoxide Cyclases from Pea Seedlings

I. Abe, U. Sankawa, Y. Ebizuka, 1992 .

Enzymatic cyclization of 26- and 27-methylidenesqualene to novel unnatural C31 polyprenoids by squalene:hopene cyclase ☆

I. Abe, H. Noguchi, Hideya Tanaka, 2004 .

The binding site for an inhibitor of squalene:hopene cyclase determined using photoaffinity labeling and molecular modeling.

G. Prestwich, I. Abe, T. Dang, 1999, Chemistry & biology.

Purification and some properties of squalene-2,3-epoxide: lanosterol cyclase from rat liver.

I. Abe, U. Sankawa, Y. Ebizuka, 1991, Chemical and pharmaceutical bulletin.

Purification of pig and rat liver squalene epoxidase by affinity chromatography

G. Prestwich, I. Abe, H. Lee, 1995 .

1-methylidenesqualene and 25-methylidenesqualene as active-site probes for bacterial squalene:hopene cyclase.

I. Abe, H. Noguchi, Hideya Tanaka, 2004, Organic letters.

Photoaffinity labeling of oxidosqualene cyclase and squalene cyclase by a benzophenone-containing inhibitor.

G. Prestwich, I. Abe, Y. Zheng, 1998, Biochemistry.

Inhibition kinetics and affinity labeling of bacterial squalene:hopene cyclase by thia-substituted analogues of 2, 3-oxidosqualene.

G. Prestwich, I. Abe, Y. Zheng, 1998, Biochemistry.

SYNTHESIS AND ENZYMATIC CYCLIZATION OF (3S)11-FLUORO-2,3-OXIDOSQUALENE

G. Prestwich, I. Abe, B. Robustell, 1998 .

Synthesis and Enzymatic Cyclization of (3S)11-Fluoro-2,3-oxidosqualene.

G. Prestwich, I. Abe, B. Robustell, 1998 .

Enzymatic formation of an unnatural hexacyclic C35 polyprenoid by bacterial squalene cyclase.

I. Abe, H. Noguchi, Hideya Tanaka, 2002, Journal of the American Chemical Society.

Inactivation of Two Triterpene Cyclases by 18(E)-(3S)-29-Methylidene-2,3-oxidosqualene

G. Prestwich, I. Abe, Y. Zheng, 1998 .

Enzymatic formation of indole-containing unnatural cyclic polyprenoids by bacterial squalene:hopene cyclase.

I. Abe, H. Noguchi, Hideya Tanaka, 2005, Organic Letters.

Enzymatic formation of an unnatural novel tetracyclic sesterterpene by β-amyrin synthase

I. Abe, H. Noguchi, Y. Ebizuka, 2004 .

Structure-based redesign of Fe(II)/2-oxoglutarate-dependent oxygenase AndA to catalyze spiro-ring formation.

I. Abe, Y. Nakashima, Takahiro Mori, 2022, Chemical communications.

Mechanism and stereochemistry of enzymatic cyclization of 24,30-Bisnor-2,3-oxidosqualene by recombinant beta-amyrin synthase.

I. Abe, H. Noguchi, Y. Ebizuka, 2004, Journal of the American Chemical Society.

Enzymatic Formation of an Unnatural Novel Tetracyclic Sesterterpene by β-Amyrin Synthase.

I. Abe, H. Noguchi, Y. Ebizuka, 2005 .

Rational Control of Polyketide Extender Units by Structure-Based Engineering of a Crotonyl-CoA Carboxylase/Reductase in Antimycin Biosynthesis.

I. Abe, Wen Liu, Takahiro Mori, 2015, Angewandte Chemie.

Biosynthetic studies on teleocidins in Streptomyces

I. Abe, 2018, The Journal of Antibiotics.

Labile natural products

I. Abe, T. Wakimoto, 2012 .

A Tryptophan Prenyltransferase with Broad Substrate Tolerance from Bacillus subtilis subsp. natto

I. Abe, Y. Nakashima, M. Okada, 2018, Chembiochem : a European journal of chemical biology.

Structural Diversification of Lyngbyatoxin A by Host‐Dependent Heterologous Expression of the tleABC Biosynthetic Gene Cluster

I. Abe, T. Wakimoto, T. Awakawa, 2016, Chembiochem : a European journal of chemical biology.

Heterochiral coupling in non-ribosomal peptide macrolactamization

I. Abe, R. Zhai, T. Wakimoto, 2020, Nature Catalysis.

Three Acyltetronic Acid Derivatives: Noncanonical Cryptic Polyketides from Aspergillus niger Identified by Genome Mining

I. Abe, T. Wakimoto, T. Awakawa, 2014, Chembiochem : a European journal of chemical biology.

Characterization of Enzymes Catalyzing the Initial Steps of the β-Lactam Tabtoxin Biosynthesis.

I. Abe, Richiro Ushimaru, Jiaqi Lyu, 2022, Organic letters.

Nonheme Iron- and 2-Oxoglutarate-Dependent Dioxygenases in Fungal Meroterpenoid Biosynthesis.

I. Abe, 2020, Chemical & pharmaceutical bulletin.

The induction of human UDP-glucuronosyltransferase 1A1 mediated through a distal enhancer module by flavonoids and xenobiotics.

I. Abe, H. Noguchi, J. Sugatani, 2004, Biochemical pharmacology.

Engineering of Plant Polyketide Biosynthesis

I. Abe, 2009 .

Structure function analysis of novel type III polyketide synthases from Arabidopsis thaliana.

I. Abe, H. Noguchi, Y. Shimokawa, 2008, Biological & pharmaceutical bulletin.

Multiple C-C Bond Cleavage Reactions Catalyzed by Tolyporphin Tetrapyrrole Biosynthetic Enzymes.

I. Abe, Richiro Ushimaru, Meiqi Ling, 2023, Journal of the American Chemical Society.

Hinduchelins A-D, Noncytotoxic Catechol Derivatives from Streptoalloteichus hindustanus.

I. Abe, Liang Yang, Fei He, 2018, Journal of natural products.

Genome-Based Discovery of an Unprecedented Cyclization Mode in Fungal Sesterterpenoid Biosynthesis.

I. Abe, H. Kawaide, Takahiro Mori, 2016, Journal of the American Chemical Society.

Structure-based engineering of a plant type III polyketide synthase: formation of an unnatural nonaketide naphthopyrone.

I. Abe, H. Noguchi, T. Kohno, 2007, Journal of the American Chemical Society.

Structural and Computational Bases for Dramatic Skeletal Rearrangement in Anditomin Biosynthesis.

I. Abe, M. Yamazaki, Y. Nakashima, 2018, Journal of the American Chemical Society.

Structural basis for olivetolic acid formation by a polyketide cyclase from Cannabis sativa

I. Abe, H. Noguchi, T. Matsui, 2016, The FEBS journal.

Elucidation and Heterologous Reconstitution of Chrodrimanin B Biosynthesis.

I. Abe, R. Zhai, T. Awakawa, 2018, Organic letters.

Heterologously expressed β-hydroxyl fatty acids from a metagenomic library of a marine sponge.

I. Abe, Y. Asakawa, T. Wakimoto, 2012, Bioorganic & medicinal chemistry letters.

Enzymatic Reactions by Five Chalcone Synthase Homologs from Hop (Humulus lupulus L.)

I. Abe, H. Noguchi, T. Kaneko, 2004, Bioscience, biotechnology, and biochemistry.

Cloning and functional analysis of a novel aldo-keto reductase from Aloe arborescens.

I. Abe, H. Noguchi, T. Kohno, 2007, Biological & pharmaceutical bulletin.

Active site residues governing substrate selectivity and polyketide chain length in aloesone synthase

I. Abe, H. Noguchi, Weiwei Lou, 2006, The FEBS journal.

Novel applications of plant polyketide synthases.

I. Abe, 2012, Current opinion in chemical biology.

Structure-based engineering of benzalacetone synthase.

I. Abe, H. Morita, Y. Shimokawa, 2010, Bioorganic & medicinal chemistry letters.

Enzymatic formation of unnatural novel polyketide scaffolds by plant-specific type III polyketide synthase

I. Abe, H. Noguchi, H. Morita, 2009 .

Structure function analysis of benzalacetone synthase from Rheum palmatum.

I. Abe, H. Noguchi, T. Kohno, 2007, Bioorganic & medicinal chemistry letters.

Enzymatic formation of an unnatural methylated triketide by plant type III polyketide synthases

I. Abe, H. Noguchi, H. Noma, 2006 .

Engineered biosynthesis of plant polyketides: manipulation of chalcone synthase.

I. Abe, H. Noguchi, T. Kohno, 2006, Organic letters.

Enzymatic formation of long-chain polyketide pyrones by plant type III polyketide synthases.

I. Abe, H. Noguchi, Tatsuya Watanabe, 2004, Phytochemistry.

Site-directed Mutagenesis of Benzalacetone Synthase

I. Abe, H. Noguchi, Yusuke Takahashi, 2003, Journal of Biological Chemistry.

Enzymatic formation of an unnatural C(6)-C(5) aromatic polyketide by plant type III polyketide synthases.

I. Abe, H. Noguchi, Yusuke Takahashi, 2002, Organic letters.

Chalcone synthase superfamily of type III polyketide synthases from rhubarb (Rheum palmatum)

I. Abe, H. Noguchi, Tatsuya Watanabe, 2005 .

Calyculin: Nature's way of making the sponge-derived cytotoxin.

I. Abe, T. Wakimoto, Yoko Egami, 2016, Natural product reports.

Molecular cloning, expression, and characterization of adenylate isopentenyltransferase from hop (Humulus lupulus L.).

I. Abe, H. Noguchi, T. Kaneko, 2004, Phytochemistry.

How structural subtleties lead to molecular diversity for the type III polyketide synthases

I. Abe, H. Morita, C. Wong, 2019, The Journal of Biological Chemistry.

C–N and C–S bond formation by cytochrome P450 enzymes

I. Abe, Richiro Ushimaru, 2023, Trends in Chemistry.

Expression, purification and crystallization of a plant polyketide cyclase from Cannabis sativa.

I. Abe, H. Noguchi, T. Matsui, 2015, Acta crystallographica. Section F, Structural biology communications.

Inhibition of vertebrate squalene epoxidase by isoprenyl gallates and phenylalkyl gallates.

I. Abe, H. Noguchi, Y. Kashiwagi, 2000, Bioorganic & medicinal chemistry letters.

Chimeric Terpene Synthases Possessing both Terpene Cyclization and Prenyltransfer Activities

I. Abe, Takaaki Mitsuhashi, 2018, Chembiochem : a European journal of chemical biology.

Identification of Chimeric αβγ Diterpene Synthases Possessing both Type II Terpene Cyclase and Prenyltransferase Activities

I. Abe, M. Okada, Takaaki Mitsuhashi, 2017, Chembiochem : a European journal of chemical biology.

Extensive expansion of the chemical diversity of fusidane-type antibiotics using a stochastic combinational strategy

I. Abe, X. Yao, Guo-dong Chen, 2020, Acta pharmaceutica Sinica. B.

Three new quassinoids isolated from the wood of Picrasma javanica and their anti-Vpr activities

Prema, I. Abe, H. Morita, 2020, Journal of Natural Medicines.

Umezawamides, new bioactive polycyclic tetramate macrolactams isolated from a combined-culture of Umezawaea sp. and mycolic acid-containing bacterium

I. Abe, H. Onaka, Shumpei Asamizu, 2018, The Journal of Antibiotics.

Molecular basis for the P450-catalyzed C–N bond formation in indolactam biosynthesis

I. Abe, Fei He, Takahiro Mori, 2019, Nature Chemical Biology.

Diverse enzymatic chemistry for propionate side chain cleavages in tetrapyrrole biosynthesis

I. Abe, Richiro Ushimaru, Jiaqi Lyu, 2023, Journal of industrial microbiology & biotechnology.

Green tea polyphenols as potent enhancers of glucocorticoid-induced mouse mammary tumor virus gene expression.

I. Abe, K. Umehara, H. Noguchi, 2001, Biochemical and biophysical research communications.

Structure function and engineering of multifunctional non-heme iron dependent oxygenases in fungal meroterpenoid biosynthesis.

I. Abe, Y. Nakashima, Takahiro Mori, 2018 .

Naturally occurring Vpr inhibitors from medicinal plants of Myanmar

I. Abe, H. Morita, N. Win, 2017, Journal of Natural Medicines.

Development of new cholesterol-lowering drugs

G. Prestwich, I. Abe, 1998 .

Understanding and Manipulating Assembly Line Biosynthesis by Heterologous Expression in Streptomyces.

I. Abe, T. Awakawa, Lihan Zhang, 2022, Methods in molecular biology.

Recent Advances in Understanding and Engineering Polyketide

I. Abe, Wenjun Zhang, Joyce Liu, 2019 .

One Polyketide Synthase, Two Distinct Products: Trans-Acting Enzyme-Controlled Product Divergence in Calbistrin Biosynthesis.

I. Abe, Takahiro Mori, Yudai Matsuda, 2021, Angewandte Chemie.

Molecular basis for carrier protein-dependent amide bond formation in the biosynthesis of lincosamide antibiotics

I. Abe, Huibin Wang, Takahiro Mori, 2023, Nature Catalysis.

Inherent atomic mobility changes in carbocation intermediates during the sesterterpene cyclization cascade

I. Abe, M. Yamazaki, M. Uchiyama, 2019, Beilstein journal of organic chemistry.

Multiplexing of combinatorial chemistry in antimycin biosynthesis: expansion of molecular diversity and utility.

I. Abe, Wen Liu, T. Awakawa, 2013, Angewandte Chemie.

Catalytic Mechanism of Nonglycosidic C–N Bond Formation by the Pseudoglycosyltransferase Enzyme VldE

I. Abe, T. Mahmud, T. Awakawa, 2023, ACS Catalysis.

Structural and Mechanistic Insights into the C-C Bond-Forming Rearrangement Reaction Catalyzed by Heterodimeric Hinokiresinol Synthase.

I. Abe, K. Miyamoto, Richiro Ushimaru, 2023, Journal of the American Chemical Society.

Protostadienol synthase from Aspergillus fumigatus: functional conversion into lanosterol synthase.

I. Abe, Y. Ebizuka, T. Kushiro, 2010, Biochemical and biophysical research communications.

Aminoacyl sulfonamide assembly in SB-203208 biosynthesis

I. Abe, Zhongjun Ma, T. Awakawa, 2019, Nature Communications.

Total Synthesis and Structural Revision of Kasumigamide, and Identification of a New Analogue

I. Abe, T. Wakimoto, Takefumi Kuranaga, 2020, Chembiochem : a European journal of chemical biology.

Functional and structural dissection of glycosyltransferases underlying the glycodiversity of wolfberry-derived bioactive ingredients lycibarbarspermidines

I. Abe, Gao-qian Wang, Guo-dong Chen, 2024, Nature communications.

Biosynthesis of Enfumafungin-type Antibiotic Reveals an Unusual Enzymatic Fusion Pattern and Unprecedented C-C Bond Cleavage.

I. Abe, Gao-qian Wang, Guo-dong Chen, 2024, Journal of the American Chemical Society.

Enzymatic Synthesis of Plant Polyketides

I. Abe, H. Noguchi, H. Morita, 2008 .