K. Någren

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Increased caudate dopamine D2 receptor availability as a genetic marker for schizophrenia.

Tyrone D. Cannon, T. V. van Erp, M. Huttunen, 2005, Archives of general psychiatry.

PET amyloid ligand [11C]PIB uptake is increased in mild cognitive impairment

M. Viitanen, S. Aalto, K. Någren, 2007, Neurology.

Regional analysis of FDG and PIB-PET images in normal aging, mild cognitive impairment, and Alzheimer’s disease

H. Rusinek, M. D. de Leon, L. Mosconi, 2008, European Journal of Nuclear Medicine and Molecular Imaging.

C957T polymorphism of the dopamine D2 receptor (DRD2) gene affects striatal DRD2 availability in vivo

K. Någren, J. Hietala, J. Rinne, 2004, Molecular Psychiatry.

C957T polymorphism of the human dopamine D2 receptor gene predicts extrastriatal dopamine receptor availability in vivo

Kjell Någren, Jussi Hirvonen, Jarmo Hietala, 2009, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Sex differences in the striatal dopamine D2 receptor binding characteristics in vivo.

K. Någren, J. Hietala, J. Rinne, 1998, The American journal of psychiatry.

Striatal D2 dopamine receptor characteristics in neuroleptic-naive schizophrenic patients studied with positron emission tomography.

V. Lehtinen, K. Någren, J. Hietala, 1994, Archives of general psychiatry.

Brain dopamine d1 receptors in twins discordant for schizophrenia.

Tyrone D. Cannon, T. V. van Erp, M. Huttunen, 2006, The American journal of psychiatry.

Striatal dopamine D1 and D2 receptor balance in twins at increased genetic risk for schizophrenia

Tyrone D. Cannon, T. V. Erp, J. Kaprio, 2006, Psychiatry Research: Neuroimaging.

COMT Val158Met Genotype Does Not Alter Cortical or Striatal Dopamine D2 Receptor Availability In Vivo

U. Pesonen, K. Någren, J. Hietala, 2010, Molecular Imaging and Biology.

Increased fibrillar amyloid-β burden in normal individuals with a family history of late-onset Alzheimer’s

S. de Santi, M. D. de Leon, S. Vallabhajosula, 2010, Proceedings of the National Academy of Sciences.

Measurement of Striatal D2 Dopamine Receptor Density and Affinity with [11C]-Raclopride in Vivo: A Test-Retest Analysis

K. Någren, J. Hietala, U. Ruotsalainen, 1999, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Cognitive reserve hypothesis: Pittsburgh Compound B and fluorodeoxyglucose positron emission tomography in relation to education in mild Alzheimer's disease

M. Viitanen, S. Aalto, K. Någren, 2008, Annals of neurology.

Conversion of amyloid positive and negative MCI to AD over 3 years

Nick C Fox, F. Turkheimer, M. Rossor, 2009, Neurology.

In vivo mapping of amyloid toxicity in Alzheimer disease

G. Frisoni, K. Någren, Marco Lorenzi, 2009, Neurology.

Voxel-based analysis of PET amyloid ligand [11C]PIB uptake in Alzheimer disease

M. Viitanen, S. Aalto, K. Någren, 2006, Neurology.

Follow-up of [11C]PIB uptake and brain volume in patients with Alzheimer disease and controls

J O Rinne, M. Viitanen, J. Lötjönen, 2009, Neurology.

Decrease in Human Striatal Dopamine D2 Receptor Density with Age: A PET Study with [11C]Raclopride

U Ruotsalainen, J O Rinne, K. Någren, 1993, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Lars Farde, Kjell Någren, Jarmo Hietala, 2000, Neurobiology of Aging.

Measurement of Serotonin 5-HT1A Receptor Binding Using Positron Emission Tomography and [carbonyl-11C]WAY-100635—Considerations on the Validity of Cerebellum as a Reference Region

Kjell Någren, Jussi Hirvonen, Jarmo Hietala, 2007 .

Effects of intravenous glucose on dopaminergic function in the human brain in vivo

Semi Helin, Kjell Någren, Harri Merisaari, 2007, Synapse.

Whole-body distribution and metabolism of [N-methyl-11C](R)-1-(2-chlorophenyl)-N-(1-methylpropyl)-3-isoquinolinecarboxamide in humans; an imaging agent for in vivo assessment of peripheral benzodiazepine receptor activity with positron emission tomography

Tuula Tolvanen, Kjell Någren, Jussi Hirvonen, 2009, European Journal of Nuclear Medicine and Molecular Imaging.

Carbon-11-methionine PET imaging of malignant melanoma.

K. Någren, H. Joensuu, U. Ruotsalainen, 1995, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

PET examination of the monoamine transporter with [11C]beta-CIT and [11C]beta-CFT in early Parkinson's disease.

K. Någren, J. Rinne, U. Ruotsalainen, 1995, Synapse.

Human biodistribution and radiation dosimetry of 11C-(R)-PK11195, the prototypic PET ligand to image inflammation

J. Hirvonen, K. Någren, S. Helin, 2010, European Journal of Nuclear Medicine and Molecular Imaging.

Temperament, character and serotonin activity in the human brain: a positron emission tomography study based on a general population cohort

J. Viikari, O. Raitakari, L. Keltikangas-Järvinen, 2012, Psychological Medicine.

[11C]palmitate kinetics across the splanchnic bed in arterial, portal and hepatic venous plasma during fasting and euglycemic hyperinsulinemia.

P. Iozzo, K. Någren, J. Knuuti, 2006, Nuclear medicine and biology.

Regional Effects of Donepezil and Rivastigmine on Cortical Acetylcholinesterase Activity in Alzheimer’s Disease

K. Någren, V. Oikonen, J. Rinne, 2002, Journal of clinical psychopharmacology.

Xenon Does Not Affect γ-Aminobutyric Acid Type A Receptor Binding in Humans

Kjell Någren, Vesa Oikonen, Elina Salmi, 2008, Anesthesia and analgesia.

Sevoflurane and Propofol Increase 11C-Flumazenil Binding to Gamma-Aminobutyric AcidA Receptors in Humans

S. Aalto, K. Någren, J. Hietala, 2004, Anesthesia and analgesia.

Use of [11C]acetate and [15O]O2 PET for the assessment of myocardial oxygen utilization in patients with chronic myocardial infarction

Kjell Någren, Hidehiro Iida, Juhani Knuuti, 2001, European Journal of Nuclear Medicine.

Myocardial efficiency during calcium sensitization with levosimendan: A noninvasive study with positron emission tomography and echocardiography in healthy volunteers

K. Någren, L. Voipio‐Pulkki, M. Saraste, 1997, Clinical pharmacology and therapeutics.

PET radioligands for dopamine receptors and re-uptake sites: chemistry and biochemistry.

K. Någren, C. Halldin, V. Pike, 1992, International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology.

Radiolabeling and biodistribution of methyl 2-(methoxycarbonyl)-2-(methylamino) bicyclo[2.1.1] -hexane -5-carboxylate, a potential neuroprotective drug.

K. Någren, K. Jokivarsi, A. Kozikowski, 2003, Life sciences.

Differential associations between brain 5-HT1A receptor binding and response to pain versus touch

Kjell Någren, Jussi Hirvonen, Jarmo Hietala, 2009, Journal of Neural Transmission.

PET studies on brain monoamine transporters with carbon-11-beta-CIT in Parkinson's disease.

K. Någren, V. Oikonen, J. Rinne, 1995, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Extrastriatal dopamine D2 and D3 receptors in early and advanced Parkinson’s disease

V Kaasinen, J O Rinne, K. Någren, 2000, Neurology.

EANM procedure guideline for brain perfusion SPECT using 99mTc-labelled radiopharmaceuticals, version 2

Jacques Darcourt, Kjell Någren, Andrea Varrone, 2009, European Journal of Nuclear Medicine and Molecular Imaging.

Human obesity is characterized by defective fat storage and enhanced muscle fatty acid oxidation, and trimetazidine gradually counteracts these abnormalities.

P. Iozzo, K. Någren, V. Oikonen, 2011, American journal of physiology. Endocrinology and metabolism.

Characterization of hepatic tumors using [11C]metomidate through positron emission tomography: comparison with [11C]acetate

K. Någren, R. Parkkola, M. Kallajoki, 2013, EJNMMI Research.

Synthesis of L- and D-[methyl-11C]methionine.

G. Antoni, B. Långström, K. Någren, 1987, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Preliminary study of carbon-11 methionine PET in the evaluation of early response to therapy in advanced breast cancer

K. Någren, H. Minn, P. Lehikoinen, 2009, Nuclear medicine communications.

1-11C-Methyl-4-Piperidinyl-N-Butyrate Radiation Dosimetry in Humans by Dynamic Organ-Specific Evaluation

K. Någren, A. Brück, J. Rinne, 2008, Journal of Nuclear Medicine.

Myocardial and peripheral vascular functional adaptation to exercise training

J. Kaprio, K. Någren, J. Knuuti, 2006, Scandinavian journal of medicine & science in sports.

Imaging of adrenal incidentalomas with PET using (11)C-metomidate and (18)F-FDG.

K. Någren, H. Minn, P. Nuutila, 2004, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Uptake of carbon-11-methionine and fluorodeoxyglucose in non-Hodgkin's lymphoma: a PET study.

K. Någren, H. Joensuu, U. Ruotsalainen, 1991, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Uptake of [N-methyl-11C]α-methylaminoisobutyric acid in untreated head and neck cancer studied by PET

K. Någren, H. Minn, K. Alanen, 2002, European Journal of Nuclear Medicine and Molecular Imaging.

Imaging of uterine carcinoma by carbon-11-methionine and PET.

K. Någren, H. Joensuu, U. Ruotsalainen, 1994, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Effects of lorazepam administration on striatal dopamine D2 receptor binding characteristics in man – a positron emission tomography study

K. Någren, J. Hietala, E. Syvälahti, 1997, Psychopharmacology.

Positron emission tomography (PET) in the study of dopamine receptors in the primate brain: evaluation of a kinetic model using 11C‐N‐methyl‐spiperone

K. Någren, P. Hartvig, H. Lundqvist, 1987, Acta neurologica Scandinavica.

Long-Term Interrelationship between Brain Metabolism and Amyloid Deposition in Mild Cognitive Impairment.

K. Någren, N. Kemppainen, R. Parkkola, 2015, Journal of Alzheimer's disease : JAD.

Syddansk Universitet Characterization of hepatic tumors using [ 11 C ] metomidate through positron emission tomography comparison with [ 11 C ] acetate

K. Någren, R. Parkkola, M. Kallajoki, 2013 .

Gender differences in brain serotonin transporter availability in panic disorder

D. Nutt, J. Tiihonen, J. Hirvonen, 2011, Journal of psychopharmacology.

Cortical ¹¹C-PIB uptake is associated with age, APOE genotype, and gender in "healthy aging".

M. Perola, M. Viitanen, A. Jula, 2014, Journal of Alzheimer's disease : JAD.

PET examination of [(11)C]5-methyl-6-nitroquipazine, a radioligand for visualization of the serotonin transporter.

J. Sandell, K. Någren, C. Halldin, 2002, Nuclear medicine and biology.

EANM procedure guidelines for brain neurotransmission SPECT/PET using dopamine D2 receptor ligands, version 2

J. Darcourt, K. Laere, K. Någren, 2010, European Journal of Nuclear Medicine and Molecular Imaging.

Measurement of serotonin 5-HT1A receptor binding using positron emission tomography and [carbonyl-11C]WAY-100635—considerations on the validity of cerebellum as a reference region

J. Hirvonen, K. Någren, J. Hietala, 2006, NeuroImage.

Free Fatty Acid Depletion Acutely Decreases Cardiac Work and Efficiency in Cardiomyopathic Heart Failure Heart Failure

K. Airaksinen, P. Iozzo, K. Någren, 2006 .

Myocardial fatty acid oxidation in patients with impaired glucose tolerance

M. Uusitupa, K. Någren, H. Sipilä, 2001, Diabetologia.

Assessment of Islet Specificity of Dihydrotetrabenazine Radiotracer Binding in Rat Pancreas and Human Pancreas

K. Någren, P. Nuutila, M. Haaparanta, 2010, The Journal of Nuclear Medicine.

Increased Brain Fatty Acid Uptake in Metabolic Syndrome

P. Iozzo, J. Hirvonen, K. Någren, 2010, Diabetes.

Uptake of 11C-Choline in Mouse Atherosclerotic Plaques

K. Någren, J. Knuuti, S. Ylä-Herttuala, 2010, Journal of Nuclear Medicine.

Posterior cortical atrophy: a rare form of dementia with in vivo evidence of amyloid-beta accumulation.

S. Aalto, K. Någren, N. Kemppainen, 2008, Journal of Alzheimer's disease : JAD.

Preparation of [1-11C]dopamine, [1-11C]p-tyramine and [1-11C]m-tyramine. Autoradiography and PET examination of [1-11C]dopamine in primates.

K. Någren, C. Halldin, L. Farde, 1993, Nuclear medicine and biology.

Carbon-11 pb-12: an attempt to visualize the dopamine d(4) receptor in the primate brain with positron emission tomography.

J. Sandell, K. Någren, C. Halldin, 2000, Nuclear medicine and biology.

(S)- and (R)-[11C]nicotine and the metabolite (R/S)-[11C]cotinine. Preparation, metabolite studies and in vivo distribution in the human brain using PET.

B. Långström, K. Någren, C. Halldin, 1992, International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology.

Comparison of [11C]methyl triflate and [11C]methyl iodide in the synthesis of PET radioligands such as [11C]β-CIT and [11C]β-CFT

K. Någren, C. Halldin, C. Swahn, 1995 .

Improved synthesis of some commonly used PET radioligands by the use of [11C]methyl triflate.

K. Någren, C. Halldin, C. Swahn, 1995, Nuclear medicine and biology.

EANM Springer Prizes 2009 Awarded

P. Schnyder, H. Rusinek, R. Stupp, 2009, European Journal of Nuclear Medicine and Molecular Imaging.

Preparation of [18F]β-CFT-FP and [11C]β-CFT-FP, selective radioligands for visualisation of the dopamine transporter using positron emission tomography (PET)

J. Sandell, K. Någren, C. Halldin, 2000 .

Biodistribution and blood metabolism of 1-11C-methyl-4-piperidinyl n-butyrate in humans: an imaging agent for in vivo assessment of butyrylcholinesterase activity with PET.

K. Någren, J. Rinne, J. Virta, 2004, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Head and neck cancer: effect of food ingestion on uptake of C-11 methionine.

K. Någren, H. Joensuu, U. Ruotsalainen, 1994, Radiology.

Measurement of striatal and thalamic dopamine D2 receptor binding with 11C-raclopride

J. Hirvonen, S. Aalto, K. Någren, 2003, Nuclear medicine communications.

Eﬀects of ﬂuoxetine on dopamine D 2 receptors in the human brain: a positron emission tomography study with [ 11 C]raclopride

J. Hirvonen, S. Aalto, K. Någren, 2004 .

Preparation of the antioestrogenic compound N-[methyl-11C]-toremifene for the study of oestrogen-receptor positive tumors in vivo

K. Någren, J. Bergman, P. Lehikoinen, 1991 .

Human subject with unexpected biodistribution of [11C]PK11195

K. Någren, J. Rinne, J. Virta, 2011 .

Xenon Does Not Affect (cid:1) -Aminobutyric Acid Type A Receptor Binding in Humans

S. Aalto, K. Någren, L. Metsähonkala, 2018 .

Positron emission tomography shows high specific uptake of racemic carbon-11 labelled norepinephrine in the primate heart

K. Någren, C. Halldin, T. Suhara, 2004, European Journal of Nuclear Medicine.

Positron emission tomography shows high specific uptake of racemic carbon-11 labelled norepinephrine in the primate heart

K. Någren, C. Halldin, T. Suhara, 1994, European Journal of Nuclear Medicine.

[11C]metaraminol, a false neurotransmitter: preparation, metabolite studies and positron emission tomography examination in monkey.

K. Någren, C. Halldin, T. Suhara, 1996, Nuclear medicine and biology.

An HPLC-method for determination of ligand metabolism during PET studies with [11C]metaraminol and [11C]norepinephrine.

K. Någren, C. Halldin, L. Farde, 1995, Nuclear medicine and biology.

Unchanged striatal dopamine transporter availability in narcolepsy: a PET studywith [11C]‐CFT

K. Någren, J. Rinne, M. Partinen, 2004, Acta neurologica Scandinavica.

Quality Control Aspects in the Preparation of [11C]-Methionine

K. Någren, 1993 .

Amyloid load in Parkinson’s disease dementia and Lewy body dementia measured with [11C]PIB positron emission tomography

C. Rowe, C. Masters, D. Brooks, 2008, Journal of Neurology, Neurosurgery, and Psychiatry.

Effects of intravenous glucose on brain dopamine D2 receptor availability in obesity

K. Någren, S. Helin, J. Rinne, 2006, NeuroImage.

Brain 5-HT2A receptor occupancy of deramciclane in humans after a single oral administration – a positron emission tomography study

K. Någren, J. Hietala, H. Kanerva, 1999, Psychopharmacology.

Synthesis of high-specific-radioactivity 4- and 6-[18F]fluorometaraminol-PET tracers for the adrenergic nervous system of the heart.

C. Crouzel, K. Någren, C. Halldin, 2001, Bioorganic & medicinal chemistry.

Myocardial efficiency during levosimendan infusion in congestive heart failure

H. Iida, K. Någren, J. Knuuti, 2000, Clinical pharmacology and therapeutics.

Striatal dopamine D1 and D2 receptors in burning mouth syndrome

Kjell Någren, Satu Jääskeläinen, Sargo Aalto, 2003, Pain.

Decreased binding of [11C]flumazenil in Angelman syndrome patients with GABAA receptor β3 subunit deletions

K. Någren, R. Parkkola, I. Holopainen, 2001, Annals of neurology.

Measurement of GABAA receptor binding in vivo with [11C]Flumazenil: A test–retest study in healthy subjects

Kjell Någren, Jussi Hirvonen, Jussi Virkkala, 2008, NeuroImage.

Five-year follow-up of 11C-PIB uptake in Alzheimer’s disease and MCI

K. Någren, N. Kemppainen, R. Parkkola, 2014, European Journal of Nuclear Medicine and Molecular Imaging.

A European multicentre PET study of fibrillar amyloid in Alzheimer’s disease

Paul Edison, David J. Brooks, Timo Grimmer, 2012, European Journal of Nuclear Medicine and Molecular Imaging.

C957T polymorphism of dopamine D2 receptor gene affects striatal DRD2 in vivo availability by changing the receptor affinity

Kjell Någren, Jarmo Hietala, Aki Laakso, 2009, Synapse.

Striatal dopamine D2 receptors in medication-naive patients with major depressive disorder as assessed with [11C]raclopride PET

Juha Markkula, Kjell Någren, Jussi Hirvonen, 2008, Psychopharmacology.

Sex differences in extrastriatal dopamine d(2)-like receptors in the human brain.

V Kaasinen, J O Rinne, K. Någren, 2001, The American journal of psychiatry.

The A1 allele of the human D2 dopamine receptor gene predicts low D2 receptor availability in healthy volunteers

J O Rinne, K. Någren, J. Hietala, 1998, Molecular Psychiatry.

Selective synthesis of racemic 1-11C-labelled norepinephrine, octopamine, norphenylephrine and phenylethanolamine using [11C]nitromethane.

K. Någren, C. Halldin, L. Farde, 1994, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

Effects of fluoxetine on dopamine D2 receptors in the human brain: a positron emission tomography study with [11C]raclopride.

Kjell Någren, Jussi Hirvonen, Jarmo Hietala, 2004, The international journal of neuropsychopharmacology.

Kinetics of four 11C-labelled enkephalin peptides in the brain, pituitary and plasma of Rhesus monkeys

B. Långström, K. Någren, P. Hartvig, 1986, Regulatory Peptides.

Biodistribution of [11C]methylaminoisobutyric acid, a tracer for PET studies on system A amino acid transport in vivo

K. Någren, T. Grönroos, M. Haaparanta, 2001, European Journal of Nuclear Medicine.

Striatal D2 dopamine receptor binding characteristics in vivo in patients with alcohol dependence

Ulla Ruotsalainen, Kjell Någren, Jarmo Hietala, 1994, Psychopharmacology.

Highly Effective Auger-Electron Therapy in an Orthotopic Glioblastoma Xenograft Model using Convection-Enhanced Delivery

K. Någren, B. Kristensen, P. Høilund-Carlsen, 2016, Theranostics.

University of Southern Denmark Highly Effective Auger-Electron Therapy in an Orthotopic Glioblastoma Xenograft Model using Convection-Enhanced Delivery Thisgaard,

K. Någren, B. Kristensen, Anne Sofie, 2016 .

Evaluation of response to radiotherapy in head and neck cancer by positron emission tomography and [11C]methionine.

K. Någren, H. Joensuu, U. Ruotsalainen, 1995, International journal of radiation oncology, biology, physics.

Carbon-11-methionine and PET in evaluation of treatment response of breast cancer.

K. Någren, U. Ruotsalainen, M. Teräs, 1993, British Journal of Cancer.

Correlation of human cold pressor pain responses with 5-HT1A receptor binding in the brain

Kjell Någren, Jussi Hirvonen, Jarmo Hietala, 2007, Brain Research.

Exercise training in chronic heart failure: beneficial effects on cardiac (11)C-hydroxyephedrine PET, autonomic nervous control, and ventricular repolarization.

K. Någren, M. Teräs, T. Jartti, 2002, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Transport of carbon-11-methionine is enhanced by insulin.

K. Någren, J. Knuuti, U. Ruotsalainen, 1997, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Decreased myocardial free fatty acid uptake in patients with idiopathic dilated cardiomyopathy: evidence of relationship with insulin resistance and left ventricular dysfunction.

P. Iozzo, K. Någren, M. Scheinin, 2006, Journal of cardiac failure.

Free Fatty Acid Depletion Acutely Decreases Cardiac Work and Efficiency in Cardiomyopathic Heart Failure

K. Airaksinen, B. Hesse, P. Iozzo, 2006, Circulation.

Altered dopamine D2 receptor binding in atypical facial pain

Kjell Någren, Juha O. Rinne, Sargo Aalto, 2003, Pain.

Metabolic characterization of childhood brain tumors

K. Någren, L. Metsähonkala, H. Minn, 2002, Cancer.

Use of carbon-11 methionine positron emission tomography to assess malignancy grade and predict survival in patients with lymphomas

K. Någren, H. Minn, P. Lindholm, 1998, European Journal of Nuclear Medicine.

Receptor binding of N-(methyl-11C) clozapine in the brain of rhesus monkey studied by positron emission tomography (PET)

B. Långström, K. Någren, P. Hartvig, 2004, Psychopharmacology.

Cortical glutamate–dopamine interaction and ketamine-induced psychotic symptoms in man

H. Tanila, J. Hirvonen, S. Aalto, 2005, Psychopharmacology.

Preparation of 4-[11C]methylmetaraminol, a potential PET tracer for assessment of myocardial sympathetic innervation: PREPARATION OF 4-[11C] METHYLMETARAMINOL

J. Sandell, B. Långström, K. Någren, 2003 .

Synthesis, radiolabeling and preliminary biological evaluation of radiolabeled 5-methyl-6-nitroquipazine, a potential radioligand for the serotonin transporter.

J. Sandell, K. Någren, C. Halldin, 2002, Bioorganic & medicinal chemistry letters.

Amino-acid-based peritoneal dialysis solution improves amino-acid transport into skeletal muscle.

K. Någren, S. Helin, J. Knuuti, 2008, Kidney international. Supplement.

EANM procedure guidelines for PET brain imaging using [18F]FDG, version 2

Koen Van Laere, Jacques Darcourt, Kjell Någren, 2009, European Journal of Nuclear Medicine and Molecular Imaging.

Radiopharmaceuticals for positron emission tomography investigations of Alzheimer’s disease

Christer Halldin, Kjell Någren, Juha O. Rinne, 2010, European Journal of Nuclear Medicine and Molecular Imaging.

Human Dosimetry of Carbon-11 Labeled N-butan-2-yl-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide Extrapolated from Whole-body Distribution Kinetics and Radiometabolism in Rats

K. Någren, S. Suilamo, A. Roivainen, 2010, Molecular Imaging and Biology.

3-isoquinolinecarboxamide in humans; an imaging agent for in vivo assessment of peripheral benzodiazepine receptor activity with positron emission tomography

J. Hirvonen, K. Någren, V. Oikonen, 2009 .

PET amyloid ligand [11C]PIB uptake shows predominantly striatal increase in variant Alzheimer's disease.

A. Paetau, M. Viitanen, S. Aalto, 2008, Brain : a journal of neurology.

Trimetazidine, a Metabolic Modulator, Has Cardiac and Extracardiac Benefits in Idiopathic Dilated Cardiomyopathy

K. Airaksinen, B. Hesse, P. Iozzo, 2008, Circulation.

Carbon 11-labeled pittsburgh compound B positron emission tomographic amyloid imaging in patients with APP locus duplication.

S. Aalto, K. Någren, N. Kemppainen, 2008, Archives of neurology.

Reduced myocardial carbon-11 hydroxyephedrine retention is associated with poor prognosis in chronic heart failure

K. Någren, L. Voipio‐Pulkki, M. Pietilä, 2001, European Journal of Nuclear Medicine.

Antagonist binding characteristics of the Ser311-->Cys variant of human dopamine D2 receptor in vivo and in vitro.

A. Cravchik, K. Någren, J. Hietala, 1997, Biochemical and biophysical research communications.

Hippocampal dopamine D2 receptors correlate with memory functions in Alzheimer's disease

M. Laakso, M. Laine, K. Någren, 2003, The European journal of neuroscience.

Frontal and Temporal Dopamine Release during Working Memory and Attention Tasks in Healthy Humans: a Positron Emission Tomography Study Using the High-Affinity Dopamine D2 Receptor Ligand [11C]FLB 457

Matti Laine, Kjell Någren, Sargo Aalto, 2005, The Journal of Neuroscience.

Amyloid and metabolic positron emission tomography imaging of cognitively normal adults with Alzheimer's parents

S. Vallabhajosula, L. Mosconi, W. Tsui, 2013, Neurobiology of Aging.

Cognitive Decline and Amyloid Accumulation in Patients with Mild Cognitive Impairment

M. Viitanen, S. Aalto, K. Någren, 2012, Dementia and Geriatric Cognitive Disorders.

PET shows that striatal dopamine D1 and D2 receptors are differentially affected in AD

K. Någren, N. Kemppainen, J. Rinne, 2000, Neurology.

Assessment of beta-amyloid in a frontal cortical brain biopsy specimen and by positron emission tomography with carbon 11-labeled Pittsburgh Compound B.

Sakari Savolainen, Kjell Någren, Ville Leinonen, 2008, Archives of neurology.

PET Amyloid Ligand [11C]PIB Uptake and Cerebrospinal Fluid β-Amyloid in Mild Cognitive Impairment

H. Soininen, M. Hallikainen, T. Hänninen, 2008, Dementia and Geriatric Cognitive Disorders.

Amyloid PET imaging in patients with mild cognitive impairment

J O Rinne, M. Viitanen, S. Aalto, 2011, Neurology.

Dopamine D2/D3 receptor binding in the anterior cingulate cortex and executive functioning

Kjell Någren, Jarmo Hietala, Sargo Aalto, 2007, Psychiatry Research: Neuroimaging.

Pancreatic glucose uptake in vivo in men with newly diagnosed type 1 diabetes.

O. Simell, P. Iozzo, K. Någren, 2008, The Journal of clinical endocrinology and metabolism.

Trimetazidine reduces endogenous free fatty acid oxidation and improves myocardial efficiency in obese humans.

P. Iozzo, K. Någren, R. Parkkola, 2012, Cardiovascular therapeutics.

Brain Cholinergic Function and Response to Rivastigmine in Patients With Chronic Sequels of Traumatic Brain Injury: A PET Study

K. Någren, V. Oikonen, J. Rinne, 2018, The Journal of head trauma rehabilitation.

[11C]PIB, [18F]FDG and MR imaging in patients with mild cognitive impairment

M. Viitanen, K. Någren, S. Helin, 2013, European Journal of Nuclear Medicine and Molecular Imaging.

Expert Testimony versus Junk Science

K. Någren, H. Joensuu, U. Ruotsalainen, 1993, Environmental Health Perspectives.

Improved syntheses of the PET radioligands, [11C]FLB 457, [11C]MDL 100907 and [11C]β‐CIT‐FE, by the use of [11C]methyl triflate

Victor W. Pike, Christer Halldin, Kjell Någren, 1998 .

The Use of Positron Emission Tomography for the Evaluation of Choline Metabolism in the Brain of the Rhesus Monkey

B. Långström, K. Någren, K. Bergström, 1986 .

[11C]PIB PET Is Associated with the Brain Biopsy Amyloid-β Load in Subjects Examined for Normal Pressure Hydrocephalus.

H. Soininen, K. Någren, J. Rinne, 2019, Journal of Alzheimer's disease : JAD.

Positron emission tomography in at risk patients and in the progression of mild cognitive impairment to Alzheimer's disease.

Kjell Någren, Juha O Rinne, K. Någren, 2010, Journal of Alzheimer's disease : JAD.

Rostrocaudal gradients of dopamine D2/3 receptor binding in striatal subregions measured with [11C]raclopride and high-resolution positron emission tomography

Jarkko Johansson, Kjell Någren, Juha O. Rinne, 2013, NeuroImage.

Comparative double-tracer whole-body autoradiography: uptake of 11C-, 18F- and 3H-labeled compounds in rat tumors.

K. Någren, C. Halldin, H. Lundqvist, 1988, International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology.

Measurement of Striatal and Extrastriatal Dopamine Transporter Binding with High-Resolution PET and [11C]PE2I: Quantitative Modeling and Test—Retest Reproducibility

Christer Halldin, Lars Farde, Jarkko Johansson, 2008, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Decreased brain serotonin 5-HT1A receptor availability in medication-naive patients with major depressive disorder: an in-vivo imaging study using PET and [carbonyl-11C]WAY-100635.

Juha Markkula, Kjell Någren, Jussi Hirvonen, 2008, The international journal of neuropsychopharmacology.

Assessment of MAO‐B Occupancy in the Brain With PET and [11C]‐L‐Deprenyl‐D2: A Dose‐Finding Study With a Novel MAO‐B Inhibitor, EVT 301

J. Hirvonen, K. Någren, H. Sipilä, 2009, Clinical pharmacology and therapeutics.

Cardiac positron emission tomography imaging with [11C]hydroxyephedrine, a specific tracer for sympathetic nerve endings, and its functional correlates in congestive heart failure.

R. Huupponen, K. Någren, J. Knuuti, 1999, The American journal of cardiology.

Fatty acid metabolism in the liver, measured by positron emission tomography, is increased in obese individuals.

P. Iozzo, K. Någren, J. Knuuti, 2010, Gastroenterology.

Insular dopamine D2 receptors and novelty seeking personality in Parkinson's disease

Kjell Någren, Valtteri Kaasinen, Sargo Aalto, 2004, Movement disorders : official journal of the Movement Disorder Society.

The lowering of hepatic fatty acid uptake improves liver function and insulin sensitivity without affecting hepatic fat content in humans.

P. Iozzo, K. Någren, R. Parkkola, 2008, American journal of physiology. Endocrinology and metabolism.

Verbal memory and 5-HT1A receptors in healthy volunteers – A PET study with [carbonyl-11C]WAY-100635

J. Hirvonen, K. Någren, J. Hietala, 2016, European Neuropsychopharmacology.

Preparation of 4-[11C]Methylmetaraminol a Potential PET Tracer for Assessment of Myocardial Sympathetic Innervation

J. Sandell, B. Långström, K. Någren, 2001 .

Preparation of 4- and 6-[76Br] bromometaraminol, two potential radiotracers for the study of the myocardial norepinephrine neuronal reuptake system with pet

C. Crouzel, K. Någren, C. Halldin, 1997 .

Substantial Thalamostriatal Dopaminergic Defect in Unverricht‐Lundborg Disease

K. Någren, R. Parkkola, M. Korja, 2007, Epilepsia.

Prolonged Central μ-Opioid Receptor Occupancy after Single and Repeated Nalmefene Dosing

S. Aalto, K. Någren, J. Hietala, 2005, Neuropsychopharmacology.

Striatal dopamine transporter and extrapyramidal symptoms in frontotemporal dementia

M. Laine, K. Någren, J. Rinne, 2002, Neurology.

Human radiation dosimetry of [11C]MeAIB, a new tracer for imaging of system A amino acid transport

K. Någren, H. Minn, P. Nuutila, 2006, European Journal of Nuclear Medicine and Molecular Imaging.

Uptake of inflammatory cell marker [11C]PK11195 into mouse atherosclerotic plaques

K. Någren, J. Knuuti, S. Ylä-Herttuala, 2008, European Journal of Nuclear Medicine and Molecular Imaging.

Measurement of Cortical Dopamine D1 Receptor Binding with [11C]SCH 23390: A Test–Retest Analysis

J. Hirvonen, K. Någren, J. Hietala, 2001, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Serotonergic modulation of striatal D2 dopamine receptor binding in humans measured with positron emission tomography

J. Tiihonen, K. Någren, J. Hietala, 1996, Psychopharmacology.

Dopamine D2 receptor binding in the human brain is associated with the response to painful stimulation and pain modulatory capacity

K. Någren, J. Hietala, A. Pertovaara, 2002, PAIN.

Intravenous Ethanol Increases Dopamine Release in the Ventral Striatum in Humans: PET Study Using Bolus-Plus-Infusion Administration of [11C]raclopride

J. Virkkala, S. Aalto, K. Någren, 2015, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

EANM procedure guidelines for brain neurotransmission SPECT using 123I-labelled dopamine transporter ligands, version 2

Koen Van Laere, Jacques Darcourt, Kjell Någren, 2010, European Journal of Nuclear Medicine and Molecular Imaging.

Upregulation of putaminal dopamine D2 receptors in early Parkinson's disease: a comparative PET study with [11C] raclopride and [11C]N-methylspiperone.

V Kaasinen, J O Rinne, K. Någren, 2000, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Increased density of dopamine D2 receptors in the putamen, but not in the caudate nucleus in early Parkinson's disease: a PET study with [11C]raclopride

Ulla Ruotsalainen, Kjell Någren, Juha O. Rinne, 1995, Journal of the Neurological Sciences.

Neuroticism and serotonin 5-HT1A receptors in healthy subjects

Lauri Tuominen, Kjell Någren, Jussi Hirvonen, 2015, Psychiatry Research: Neuroimaging.

Temperament trait Harm Avoidance associates with μ-opioid receptor availability in frontal cortex: A PET study using [11C]carfentanil

Lauri Tuominen, Kjell Någren, Jussi Hirvonen, 2012, NeuroImage.

Ketamine does not decrease striatal dopamine D2 receptor binding in man

J. Hirvonen, S. Aalto, K. Någren, 2002, Psychopharmacology.

Dopaminergic effects of caffeine in the human striatum and thalamus

S. Aalto, K. Någren, J. Rinne, 2004, Neuroreport.

Striatal uptake of the dopamine reuptake ligand [11C]β-CFT is reduced in Alzheimer's disease assessed by positron emission tomography

K. Någren, J. Rinne, H. Ruottinen, 1998, Neurology.

Effects of cocaine on [11C]norepinephrine and [11C]β-CIT uptake in the primate peripheral organs measured by PET

K. Någren, C. Halldin, T. Suhara, 1996, Annals of nuclear medicine.

[11C]methionine quantitation in cancer PET studies.

K. Någren, H. Joensuu, U. Ruotsalainen, 1992, Journal of computer assisted tomography.

Uptake of 11C-methionine in breast cancer studied by PET. An association with the size of S-phase fraction.

K. Någren, H. Joensuu, U. Ruotsalainen, 1991, British Journal of Cancer.

Measurement of central µ-opioid receptor binding in vivo with PET and [11C]carfentanil: a test–retest study in healthy subjects

Kjell Någren, Kimmo Ingman, Jussi Hirvonen, 2009, European Journal of Nuclear Medicine and Molecular Imaging.

Carbon-11-methionine and PET is an effective method to image head and neck cancer.

U Ruotsalainen, M Teräs, K. Någren, 1992, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Amino acid uptake in the skeletal muscle measured using [11C]methylaminoisobutyrate (MEAIB) and PET

K. Någren, J. Knuuti, P. Nuutila, 2002, European Journal of Nuclear Medicine and Molecular Imaging.

Brain acetylcholinesterase activity in mild cognitive impairment and early Alzheimer’s disease

K. Någren, V. Oikonen, J. Rinne, 2003, Journal of neurology, neurosurgery, and psychiatry.

Chapter 2 – Application of 18F‐PET Imaging for the Study of Alzheimer's Disease

K. Någren, J. Rinne, 2008 .

PET demonstrates different behaviour of striatal dopamine D‐1 and D‐2 receptors in early Parkinson's disease

K. Någren, J. Rinne, U. Ruotsalainen, 1990, Journal of neuroscience research.

[(11)C]PIB-, [(18)F]FDG-PET and MRI imaging in patients with Parkinson's disease with and without dementia.

S. Aalto, K. Någren, R. Parkkola, 2010, Parkinsonism & related disorders.

Kjell Någren, Valtteri Kaasinen, Timo Kurki, 2002, Journal of neurochemistry.

PET studies on dopamine D1 receptors in the human brain with carbon-11-SCH 39166 and carbon-11-NNC 756.

J O Rinne, K. Någren, V. Oikonen, 1994, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Comparison of fluorine-18-fluorodeoxyglucose and carbon-11-methionine in head and neck cancer.

U Ruotsalainen, M Teräs, K. Någren, 1993, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[11 C]Flumazenil binding in the medial temporal lobe in patients with temporal lobe epilepsy: correlation with hippocampal MR volumetry, T2 relaxometry, and neuropathology.

M Vapalahti, J O Rinne, A. Ylinen, 2000, Neurology.

Cholinergic dysfunction after traumatic brain injury

K. Någren, V. Oikonen, J. Rinne, 2011, Neurology.

Research Letter: Psychotherapy increases brain serotonin 5-HT1A receptors in patients with major depressive disorder

J. Hirvonen, S. Aalto, K. Någren, 2009, Psychological Medicine.

The dopamine D2 receptor 5'-flanking variant, -141C Ins/Del, is not associated with reduced dopamine D2 receptor density in vivo.

K. Någren, J. Hietala, T. Pohjalainen, 1999, Pharmacogenetics.

Extrastriatal dopamine D2 receptors in Parkinson's disease: a longitudinal study

S. Aalto, K. Någren, J. Hietala, 2003, Journal of Neural Transmission.

Radiosynthesis and Evaluation of 11C-CIMBI-5 as a 5-HT2A Receptor Agonist Radioligand for PET

Anders Ettrup, Nic Gillings, Gitte M. Knudsen, 2010, The Journal of Nuclear Medicine.

PET examination of the monoamine transporter with [11c]β‐CIT and [11c]β‐CFT in early parkinson's disease

K. Någren, J. Rinne, A. Laihinen, 1995 .

Striatal dopaminergic system in dopa-responsive dystonia: a multi-tracer PET study shows increased D2 receptors

K. Någren, L. Metsähonkala, J. Rinne, 2004, Journal of Neural Transmission.

Biodistribution and radiation dosimetry of the amyloid imaging agent 11C-PIB in humans.

K. Någren, I. Wilson, J. Rinne, 2007, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Positron emission tomography shows reduced striatal dopamine D1 but not D2 receptors in juvenile neuronal ceroid lipofuscinosis.

K. Någren, J. Rinne, H. Ruottinen, 2002, Neuropediatrics.

Author reply to: “Depressive symptomatology, serotonergic activity, and neuroticism: A methodological recommendation”

J. Hirvonen, K. Någren, J. Hietala, 2015, Psychiatry Research: Neuroimaging.

Methylation of amide and thiol functions with [11C]methyl triflate, as exemplified by [11C]NMSP[11C]flumazenil and [11C]methionine

Christer Halldin, Kjell Någren, K. Någren, 1998 .

Metabolic imaging of ovarian tumors with carbon-11-methionine: a PET study.

K. Någren, H. Joensuu, U. Ruotsalainen, 1995, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

A comparative study on the reaction of 11CO2 with alkyl metal reagents

B. Långström, K. Någren, 1989 .

Distribution and Kinetics of 11 C-Labelled Substance P, Met-Enkephalin and Related Peptides in the Head of the Rhesus Monkey

B. Långström, K. Någren, P. Hartvig, 1988 .

Protected homocysteine peptides as precursors of labelled methionine peptides. Application in preparation of methionine-enkephalin.

B. Långström, K. Någren, U. Ragnarsson, 1985, Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry.

The synthesis of 1-11C-labelled ethyl, propyl, butyl and isobutyl iodides and examples of alkylation reactions

G. Antoni, B. Långström, K. Någren, 1986 .

An alternative synthesis of DL-[1-11C]alanine from [11C]HCN

K. Någren, Toshihiro Takahashi, K. Aho, 1990 .

Synthesis of three 11C‐labelled methionine‐containing enkephal in analogues

B. Långström, K. Någren, U. Ragnarsson, 1988 .

The synthesis of the neuropeptide Met-enkephalin and two metabolic fragments labelled with 11C in the methionine methyl group.

B. Långström, K. Någren, U. Ragnarsson, 1986, International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes.

PET study on striatal dopamine D2 receptor changes during the progression of early parkinson's disease

U Ruotsalainen, J O Rinne, K. Någren, 1993, Movement disorders : official journal of the Movement Disorder Society.

Synthesis of D/L- and L-SE-[methyl-11C]selenomethionine

B. Långström, K. Någren, 1988 .

A PET Tracer for Brain α2C Adrenoceptors, 11C-ORM-13070: Radiosynthesis and Preclinical Evaluation in Rats and Knockout Mice

K. Någren, S. Helin, M. Scheinin, 2014, The Journal of Nuclear Medicine.

Development of an automated modular system for the synthesis of [11C]acetate

K. Någren, C. Felicini, G. Pascali, 2010, Nuclear medicine communications.

Effects of intravenous placebo with glucose expectation on human basal ganglia dopaminergic function

K. Någren, S. Helin, R. Parkkola, 2008, Synapse.

μ‐Receptor agonism with alfentanil increases striatal dopamine D2 receptor binding in man

Kjell Någren, Jarmo Hietala, Harry Scheinin, 2002, Synapse.

Measurement of extrastriatal D2-like receptor binding with [11C]FLB 457 – a test-retest analysis

Kjell Någren, Jarmo Hietala, Vesa Oikonen, 2000, European Journal of Nuclear Medicine.

Myocardial blood flow and adenosine A2A receptor density in endurance athletes and untrained men

S. Nesterov, K. Någren, V. Oikonen, 2008, The Journal of physiology.

Association of striatal dopamine D2/D3 receptor binding potential with pain but not tactile sensitivity or placebo analgesia

K. Någren, J. Hietala, A. Pertovaara, 2005, Neuroscience Letters.

Striatal dopamine D2/D3 receptor availability correlates with individual response characteristics to pain

K. Någren, J. Hietala, A. Pertovaara, 2004, The European journal of neuroscience.

Good manufacturing practice production of the system A amino acid transport tracer [11C]MeAIB on a commercial synthesis module

K. Någren, J. Dam, 2014 .

Alfentanil increases cortical dopamine D2/D3 receptor binding in healthy subjects

Kjell Någren, Jarmo Hietala, Vesa Oikonen, 2004, Pain.

The effects of lorazepam on extrastriatal dopamine D2/3-receptors—A double-blind randomized placebo-controlled PET study

S. Aalto, K. Någren, J. Hietala, 2009, Psychiatry Research: Neuroimaging.

A PET Study on the Acute Effect of Ethanol on Striatal D2 Dopamine Receptors with [11C]Raclopride in Healthy Males

Ulla Ruotsalainen, Kjell Någren, Jarmo Hietala, 1997 .

[N‐methyl‐11C]MeAIB, a tracer for system A amino acid transport: preparation from [11C]methyl triflate and HPLC metabolite analysis of plasma samples after intravenous administration in man

K. Någren, S. Jyrkkiö, E. Sutinen, 2000 .

Brain serotonin 1A receptor binding in bulimia nervosa

A. Rissanen, J. Tiihonen, K. Någren, 2004, Biological Psychiatry.

Subanesthetic Ketamine Does Not Affect 11C-Flumazenil Binding in Humans

S. Aalto, K. Någren, J. Hietala, 2005, Anesthesia and analgesia.

Reproducibility of Striatal and Thalamic Dopamine D2 Receptor Binding Using [11C]raclopride with High-Resolution Positron Emission Tomography

Matti Laine, Kjell Någren, Vesa Oikonen, 2011, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Precursor synthesis and radiolabelling of the dopamine D2 receptor ligand (11C)raclopride from (11C)methyl triflate

Christer Halldin, Kjell Någren, Johan Sandell, 1999 .

Striatal μ-opioid receptor availability predicts cold pressor pain threshold in healthy human subjects

U. Pesonen, S. Aalto, K. Någren, 2012, Neuroscience Letters.

Effects of antidepressant drug treatment and psychotherapy on striatal and thalamic dopamine D2/3 receptors in major depressive disorder studied with [11C]raclopride PET

J. Hirvonen, S. Aalto, K. Någren, 2011, Journal of psychopharmacology.

Positron emission tomography study of human narcolepsy

K. Någren, J. Rinne, U. Ruotsalainen, 1995, Neurology.

The effects of d-amphetamine on extrastriatal dopamine D2/D3 receptors: a randomized, double-blind, placebo-controlled PET study with [11C]FLB 457 in healthy subjects

Kjell Någren, Jussi Hirvonen, Jarmo Hietala, 2009, European Journal of Nuclear Medicine and Molecular Imaging.

Cortical dopamine D2/D3 receptors and verbal memory in man

Kjell Någren, Jussi Hirvonen, Jarmo Hietala, 2010, NeuroImage.