Z. Xiang

发表

Modulation of spontaneous firing in rat subthalamic neurons by 5-HT receptor subtypes.

S. T. Kitai, Z. Xiang, Lie-cheng Wang, 2005, Journal of neurophysiology.

GABA A receptor-mediated currents in interneurons and pyramidal cells of rat visual cortex

D. Prince, J. Huguenard, Z. Xiang, 1998 .

GABAA receptor‐mediated currents in interneurons and pyramidal cells of rat visual cortex

D. Prince, J. Huguenard, Z. Xiang, 1998, The Journal of physiology.

Cholinergic switching within neocortical inhibitory networks.

D. Prince, J. Huguenard, J. Huguenard, 1998, Science.

Discovery, Characterization, and Antiparkinsonian Effect of Novel Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4

Kari A. Johnson, Z. Xiang, C. Lindsley, 2008, Molecular Pharmacology.

Unique Signaling Profiles of Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Determine Differences in In Vivo Activity

F. Dudek, K. Gregory, Z. Xiang, 2013, Biological Psychiatry.

VU0477573: Partial Negative Allosteric Modulator of the Subtype 5 Metabotropic Glutamate Receptor with In Vivo Efficacy

Brittney S. Bates, K. Gregory, Z. Xiang, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Synaptic inhibition of pyramidal cells evoked by different interneuronal subtypes in layer v of rat visual cortex.

John R Huguenard, D. Prince, J. Huguenard, 2002, Journal of neurophysiology.

Biotransformation of a Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Contributes to Seizure-Like Adverse Events in Rats Involving a Receptor Agonism-Dependent Mechanism

Z. Xiang, C. Lindsley, P. Conn, 2013, Drug Metabolism and Disposition.

Functional impact of allosteric agonist activity of selective positive allosteric modulators of mGlu 5 in regulating CNS function

H. Lavreysen, Z. Xiang, C. Lindsley, 2011 .

Co-Activation of Metabotropic Glutamate Receptor 3 and Beta-Adrenergic Receptors Modulates Cyclic-AMP and Long-Term Potentiation, and Disrupts Memory Reconsolidation

D. Sheffler, Z. Xiang, C. Lindsley, 2017, Neuropsychopharmacology.

Identification of Positive Allosteric Modulators VU0155094 (ML397) and VU0422288 (ML396) Reveals New Insights into the Biology of Metabotropic Glutamate Receptor 7

Bruce J. Melancon, K. Gregory, Z. Xiang, 2014, ACS chemical neuroscience.

Differential activity of mGlu7 allosteric modulators provides evidence for mGlu7/8 heterodimers at hippocampal Schaffer collateral-CA1 synapses

Z. Xiang, J. Javitch, C. Lindsley, 2022, The Journal of biological chemistry.

Role of mGlu5 Receptors and Inhibitory Neurotransmission in M1 Dependent Muscarinic LTD in the Prefrontal Cortex: Implications in Schizophrenia.

S. P. Moran, Z. Xiang, C. Lindsley, 2017, ACS chemical neuroscience.

Development of Novel, CNS Penetrant Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 1 (mGlu1), Based on an N-(3-Chloro-4-(1,3-dioxoisoindolin-2-yl)phenyl)-3-methylfuran-2-carboxamide Scaffold, That Potentiate Wild Type and Mutant mGlu1 Receptors Found in Schizophrenics

Anna L. Blobaum, Z. Xiang, C. Lindsley, 2015, Journal of medicinal chemistry.

M1-positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition

S. P. Moran, Z. Xiang, C. Lindsley, 2018, Neuropsychopharmacology.

Positive allosteric modulators (PAMs) of the group II metabotropic glutamate receptors: Design, synthesis, and evaluation as ex-vivo tool compounds.

Bruce J. Melancon, Z. Xiang, C. Lindsley, 2021, Bioorganic & medicinal chemistry letters.

Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinamide (ML254).

K. Gregory, J. Meiler, Z. Xiang, 2013, Journal of medicinal chemistry.

Acute restraint stress redirects prefrontal cortex circuit function through mGlu5 receptor plasticity on somatostatin-expressing interneurons

Brenda C. Shields, Z. Xiang, C. Lindsley, 2022, Neuron.

The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson's Disease.

Bruce J. Melancon, Z. Xiang, O. McManus, 2011, ACS chemical neuroscience.

Hippocampal circuitry complicates analysis of long‐term potentiation in mossy fiber synapses

T. H. Brown, B. Claiborne, Z. Xiang, 1993, Hippocampus.

Biased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5 Modulation of NMDAR Currents

Kari A. Johnson, K. Gregory, J. Bartolomé-Nebreda, 2015, Neuron.

Functional Impact of Allosteric Agonist Activity of Selective Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 in Regulating Central Nervous System Function

H. Lavreysen, Z. Xiang, C. Lindsley, 2012, Molecular Pharmacology.

A Selective Allosteric Potentiator of the M1 Muscarinic Acetylcholine Receptor Increases Activity of Medial Prefrontal Cortical Neurons and Restores Impairments in Reversal Learning

M. Quirk, A. Levey, E. Christian, 2009, The Journal of Neuroscience.

M1 muscarinic activation induces long-lasting increase in intrinsic excitability of striatal projection neurons

Z. Xiang, C. Lindsley, P. Conn, 2017, Neuropharmacology.

Novel Selective Allosteric Activator of the M1 Muscarinic Acetylcholine Receptor Regulates Amyloid Processing and Produces Antipsychotic-Like Activity in Rats

A. Deutch, A. Levey, R. Kessler, 2008, The Journal of Neuroscience.

Activating mGlu3 Metabotropic Glutamate Receptors Rescues Schizophrenia-like Cognitive Deficits Through Metaplastic Adaptations Within the Hippocampus

Z. Xiang, F. Nicoletti, C. Lindsley, 2020, Biological Psychiatry.

Metabotropic glutamate receptor 3 activation is required for long-term depression in medial prefrontal cortex and fear extinction

Cody J. Wenthur, Z. Xiang, C. Lindsley, 2015, Proceedings of the National Academy of Sciences.

Cholinergic Projections to the Substantia Nigra Pars Reticulata Inhibit Dopamine Modulation of Basal Ganglia through the M4 Muscarinic Receptor

J. Wess, Z. Xiang, C. Lindsley, 2017, Neuron.

A Novel Selective Muscarinic Acetylcholine Receptor Subtype 1 Antagonist Reduces Seizures without Impairing Hippocampus-Dependent Learning

S. Jadhav, D. Sheffler, Z. Xiang, 2009, Molecular Pharmacology.

mGlu7 potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndrome

Anna L. Blobaum, Z. Xiang, C. Lindsley, 2017, Science Translational Medicine.

The Role of mGlu Receptors in Hippocampal Plasticity Deficits in Neurological and Psychiatric Disorders: Implications for Allosteric Modulators as Novel Therapeutic Strategies

Z. Xiang, P. Conn, C. Niswender, 2016, Current neuropharmacology.

Recombinant vesicular stomatitis virus vectors as oncolytic agents in the treatment of high-grade gliomas in an organotypic brain tissue slice-glioma coculture model.

Z. Xiang, Qihong Zhou, L. Pfeffer, 2004, Journal of neurosurgery.

Novel Allosteric Agonists of M1 Muscarinic Acetylcholine Receptors Induce Brain Region-Specific Responses That Correspond with Behavioral Effects in Animal Models

M. Foster Olive, J. Scott Daniels, P. Jeffrey Conn, 2012, The Journal of Neuroscience.

A Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 2 Blocks a Hallucinogenic Drug Model of Psychosis

Z. Xiang, P. Conn, E. sanders-Bush, 2007, Molecular Pharmacology.

Antipsychotic-like Effects of M4 Positive Allosteric Modulators Are Mediated by CB2 Receptor-Dependent Inhibition of Dopamine Release

M. J. Uddin, J. Wess, Z. Xiang, 2016, Neuron.

M4 mAChR-mediated modulation of glutamatergic transmission at corticostriatal synapses.

Y. Smith, Z. Xiang, C. Lindsley, 2014, ACS chemical neuroscience.

Roles of the M 1 Muscarinic Acetylcholine Receptor Subtype in the Regulation of Basal Ganglia Function and Implications for the Treatment of Parkinson ’ s Disease

Z. Xiang, C. Lindsley, P. Conn, 2012 .

Roles of the M1 Muscarinic Acetylcholine Receptor Subtype in the Regulation of Basal Ganglia Function and Implications for the Treatment of Parkinson's Disease

Z. Xiang, C. Lindsley, P. Conn, 2012, Journal of Pharmacology and Experimental Therapeutics.

and PKC Afterpotential in Rat Jaw-Closing Motoneurons by PKA Serotonergic Modulation of the Hyperpolarizing Spike

C. Heckman, Masayuki Kobayashi, S. H. Chandler, 2013 .

mGlu5 Positive Allosteric Modulators Facilitate Long-Term Potentiation via Disinhibition Mediated by mGlu5-Endocannabinoid Signaling

Z. Xiang, C. Lindsley, P. Conn, 2019, ACS pharmacology & translational science.

Allosteric activation of M4 muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 mice

Z. Xiang, C. Lindsley, P. Conn, 2015, Proceedings of the National Academy of Sciences.

An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission.

Kari A. Johnson, J. Wess, Z. Xiang, 2008, Nature chemical biology.

Heterogeneous actions of serotonin on interneurons in rat visual cortex.

D. Prince, Z. Xiang, David A Prince, 2003, Journal of neurophysiology.

Input-specific regulation of glutamatergic synaptic transmission in the medial prefrontal cortex by mGlu2/mGlu4 receptor heterodimers

Z. Xiang, J. Javitch, C. Lindsley, 2021, Science Signaling.

Biased M1 receptor–positive allosteric modulators reveal role of phospholipase D in M1-dependent rodent cortical plasticity

S. P. Moran, Z. Xiang, C. Lindsley, 2019, Science Signaling.

Biased M1 positive allosteric modulators reveal novel role of phospholipase D in M1-dependent rodent cortical plasticity

S. P. Moran, Z. Xiang, C. Lindsley, 2019, bioRxiv.

Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system.

S. Jadhav, J. Meiler, Z. Xiang, 2010, ACS chemical neuroscience.

Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system.

S. Jadhav, J. Meiler, Z. Xiang, 2010, ACS chemical neuroscience.

mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning

M. Foster Olive, P. Jeffrey Conn, Craig W. Lindsley, 2009, Neuropsychopharmacology.

Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071.

D. Sheffler, Z. Xiang, C. Lindsley, 2011, Bioorganic & medicinal chemistry letters.

Modulation of excitatory synaptic transmission by endogenous glutamate acting on presynaptic group II mGluRs in rat substantia nigra compacta

Z. Xiang, Lie-cheng Wang, S. Kitai, 2005, Journal of neuroscience research.

in the Hippocampus Receptors Persistently Active Metabotropic Glutamate Reduction of Excitatory Postsynaptic Responses by

José R. Donoso, P. Somogyi, R. Kempter, 2015 .

Ultrasound neuromodulation depends on pulse repetition frequency and can modulate inhibitory effects of TTX

Z. Xiang, J. Kusunose, C. Caskey, 2020, Scientific Reports.

M5 Receptor Activation Produces Opposing Physiological Outcomes in Dopamine Neurons Depending on the Receptor's Location

D. Sulzer, Z. Xiang, C. Lindsley, 2014, The Journal of Neuroscience.

Epileptiform Discharges in Hippocampal Slices Role of Synaptic Metabotropic Glutamate Receptors in

R. Wong, Z. Xiang, P. Conn, 2015 .

Influence of M1 muscarinic acetylcholine receptor activation on arousal and cognitive performance using electroencephalography and novel touchscreen cognition assessment (845.5)

J. Wess, Z. Xiang, C. Lindsley, 2014 .

Activity-Dependent Bidirectional Modification of Inhibitory Synaptic Transmission in Rat Subthalamic Neurons

Z. Xiang, Lie-cheng Wang, S. Kitai, 2006, The Journal of Neuroscience.