H. Polzer

发表

The target landscape of clinical kinase drugs

Heiner Koch, B. Kuster, R. Preissner, 2017, Science.

Exome sequencing identifies recurring FLT3 N676K mutations in core-binding factor leukemia.

W. Hiddemann, S. Bohlander, H. Blum, 2012, Blood.

Activating FLT3 Mutants Show Distinct Gain-of-Function Phenotypes In Vitro and a Characteristic Signaling Pathway Profile Associated with Prognosis in Acute Myeloid Leukemia

W. Hiddemann, S. Bohlander, H. Polzer, 2014, PloS one.

Therapeutic Discovery Breakdown of the FLT 3-ITD / STAT 5 Axis and Synergistic Apoptosis Induction by the Histone Deacetylase Inhibitor Panobinostat and FLT 3-Speci fi c Inhibitors

H. Polzer, K. Spiekermann, T. Heinzel, 2012 .

Tyrosine kinase inhibition increases the cell surface localization of FLT3-ITD and enhances FLT3-directed immunotherapy of acute myeloid leukemia

W. Hiddemann, K. Metzeler, H. Leonhardt, 2017, Leukemia.

A series of novel aryl-methanone derivatives as inhibitors of FMS-like tyrosine kinase 3 (FLT3) in FLT3-ITD-positive acute myeloid leukemia.

B. Kuster, Susan Klaeger, H. Polzer, 2020, European journal of medicinal chemistry.

Breakdown of the FLT3-ITD/STAT5 Axis and Synergistic Apoptosis Induction by the Histone Deacetylase Inhibitor Panobinostat and FLT3-Specific Inhibitors

H. Polzer, K. Spiekermann, T. Heinzel, 2012, Molecular Cancer Therapeutics.

- 1-Breakdown of the FLT 3-ITD / STAT 5 axis and synergistic apoptosis induction by the histone deacetylase inhibitor Panobinostat and FLT 3-specific inhibitors

H. Polzer, K. Spiekermann, T. Heinzel, 2012 .

The new and recurrent FLT3 juxtamembrane deletion mutation shows a dominant negative effect on the wild-type FLT3 receptor

W. Hiddemann, K. Metzeler, H. Polzer, 2016, Scientific Reports.

Microenvironmental Hypoxia regulates FLT3 expression and biology in AML

H. Polzer, K. Spiekermann, M. Fiegl, 2015, Scientific Reports.

Individualized Treatment Strategy with Small-Molecular Inhibitors inAcute Myeloid Leukemia with Concurrent FLT3-ITD and FLT3-TKDMutation

W. Hiddemann, H. Polzer, K. Spiekermann, 2015 .

Casitas B-lineage lymphoma mutants activate AKT to induce transformation in cooperation with class III receptor tyrosine kinases.

W. Hiddemann, H. Polzer, K. Spiekermann, 2013, Experimental hematology.