R. Thorpe

R. Thorpe, A. Mire-Sluis, K. Zoon, 1996, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

The production and characterisation of monoclonal antibodies against human prolactin and the development of a two-site immunoradiometric assay.

R. Thorpe, V. Patel, S. Jeffcoate, 1989, Journal of immunoassay.

Evidence for a signaling role for the alpha chains of granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and IL-5 receptors: divergent signaling pathways between GM-CSF/IL-3 and IL-5.

M. Wadhwa, R. Thorpe, A. Mire-Sluis, 1995, Blood.

Immunochemistry in practice

R. Thorpe, A. Johnstone, 1982 .

After TGN1412: Recent developments in cytokine release assays

R. Thorpe, R. Stebbings, D. Eastwood, 2012, Journal of immunotoxicology.

Monoclonal antibodies to crosslinked fibrin degradation products (XL‐FDP) I. CHARACTERIZATION AND PRELIMINARY EVALUATION IN PLASMA

R. Thorpe, P. Gaffney, M. Spitz, 1988, British journal of haematology.

Implications for the assay and biological activity of interleukin-8: results of a WHO international collaborative study.

R. Thorpe, A. Mire-Sluis, R. G. Gaines Das, 1997, Journal of immunological methods.

Implications for the assay and biological activity of interleukin-4. Results of a WHO international collaborative study.

R. G. Das, R. Thorpe, A. Mire-Sluis, 1996, Journal of immunological methods.

The international standard for granulocyte colony stimulating factor (G-CSF). Evaluation in an international collaborative study. Participants of the Collaborative Study.

R. G. Das, R. Thorpe, A. Mire-Sluis, 1995, Journal of immunological methods.

The international standard for macrophage colony stimulating factor (M-CSF). Evaluation in an international collaborative study.

R. G. Das, R. Thorpe, A. Mire-Sluis, 1995, Journal of immunological methods.

Inhibition of interleuk:in‐2 secretion by factor VIII concentrates: a possible cause of immunosuppression in haemophiliacs

P. Dilger, R. Thorpe, T. Barrowcliffe, 1989, British journal of haematology.

Harmonization and standardization of immunogenicity assessment of biotherapeutic products.

M. Wadhwa, R. Thorpe, 2019, Bioanalysis.

Production and assay of the interleukins.

R. Thorpe, A. Gearing, A. Johnstone, 1985, Journal of immunological methods.

Incidence of GM-CSF antibodies in cancer patients receiving GM-CSF for immunostimulation.

M. Wadhwa, C. Bird, R. Thorpe, 2001, Clinical immunology.

Development of a continuous IL-7-dependent murine pre-B cell line PB-1 suitable for the biological characterisation and assay of human IL-7.

R. Thorpe, A. Mire-Sluis, S. Griffiths, 2000, Journal of immunological methods.

Establishment of the first WHO Erythropoietin antibody reference panel: Report of an international collaborative study.

Troy E. Barger, M. Wadhwa, C. Bird, 2016, Journal of immunological methods.

Cytokines in WBC‐reduced apheresis PCs during storage: a comparison of two WBC‐reduction methods

M. Wadhwa, P. Dilger, R. Thorpe, 2000, Transfusion.

Cytokine accumulation in stored red cell concentrates: effect of buffy-coat removal and leucoreduction.

M. Wadhwa, P. Dilger, R. Thorpe, 2000, Transfusion science.

An improved immunoblotting procedure for the detection of antibodies against HIV.

A. J. Garrett, C. Bird, R. Thorpe, 1987, Journal of virological methods.

Monoclonal antibodies to crosslinked fibrin degradation products (XL‐FDP) II. EVALUATION IN A VARIETY OF CLINICAL CONDITIONS

R. Thorpe, P. Gaffney, L. Creighton, 1988, British journal of haematology.

Immunochemical characterization of a new platelet specific monoclonal antibody and its use to demonstrate the cytoskeletal association of the platelet glycoprotein IIb-IIIa complex

C. Bird, R. Thorpe, M. Callus, 1986, Bioscience reports.

The significance of carbohydrates on G‐CSF: differential sensitivity of G‐CSFs to human neutrophil elastase degradation

R. Thorpe, C. Carter, K. Whitmore, 2004, Journal of leukocyte biology.

Modulation of the serological response to meningococcal polysaccharides by cytokines.

R. Thorpe, M. Corbel, M. A. Cortés-Castillo, 2001, Vaccine.

Comparison of novel methods for predicting the risk of pro-inflammatory clinical infusion reactions during monoclonal antibody therapy.

M. Wadhwa, C. Bird, R. Thorpe, 2011, Journal of immunological methods.

Book reviewThe cytokine facts book: Callard, R. and Gearing A., vii + 265 pp. academic Press, London, 1994. Paperback GBP 19.50, ISBN 0-12-155143-1

R. Thorpe, 1995 .

Intrasplenic primary immunization for the production of monoclonal antibodies.

R. Thorpe, M. Spitz, E. Eugui, 1984, Journal of immunological methods.

Human B cell proliferation is stimulated by interleukin 2.

R. Thorpe, A. Gearing, M. Spitz, 1985, Immunology letters.

Immunoblotting with monoclonal antibodies: loss of immunoreactivity with human immunoglobulins arises from polypeptide chain separation.

C. Bird, R. Thorpe, M. Spitz, 1984, Journal of immunological methods.

STANDARDIZATION AND CALIBRATION OF CYTOKINE IMMUNOASSAYS

M. Wadhwa, R. Thorpe, A. Mire-Sluis, 1999 .

Multiple proteins related to the soluble galactose-binding animal lectin revealed by a monoclonal anti-lectin antibody.

R. Thorpe, S. Carding, M. Spitz, 1985, The Biochemical journal.

Transformation and growth related changes in levels of nuclear and cytoplasmic proteins antigenically related to mammalian beta-galactoside-binding lectin.

R. Thorpe, S. Carding, S. Thorpe, 1985, Biochemical and biophysical research communications.

Immunochemical studies of polioviruses: identification of immunoreactive virus capsid polypeptides.

R. Thorpe, G. Schild, P. Minor, 1982, The Journal of general virology.

New methods of analysing for antigens and glycoproteins in complex mixtures.

R. Thorpe, B. Anderton, 1980, Immunology today.

HTLV-1 infection in Papua New Guinea: evidence for serologic false positivity.

P. Dilger, R. Thorpe, N. Banatvala, 1989, The Journal of infectious diseases.

Procogulant Activities of Leukocytes

R. Thorpe, T. Barrowcliffe, E. Gray, 1990 .

Presence of the inflammatory cytokines IL-1, TNF, and IL-6 in preparations of monoclonal antibodies.

C. Bird, R. Thorpe, A. Gearing, 1989, Hybridoma.

Purification of IgG by Precipitation with Sodium Sulfate or Ammonium Sulfate

R. Thorpe, M. Page, 1996 .

Regulatory challenges with biosimilars: an update from 20 countries

Shraddha Srivastava, M. Wadhwa, R. Thorpe, 2020, Annals of the New York Academy of Sciences.

Immobilized affinity ligand techniques

R. Thorpe, 1993 .

Severity of the TGN1412 trial disaster cytokine storm correlated with IL-2 release

M. Wadhwa, P. Dilger, C. Bird, 2013, British journal of clinical pharmacology.

The 2nd International Standard for Interleukin-2 (IL-2). Report of a collaborative study.

M. Wadhwa, P. Dilger, C. Bird, 2013, Journal of immunological methods.

INTERFERON-α PRIMES EARLY PROLIFERATIVE RESPONSE OF BONE MARROW CELLS IN VIVO

H. Katinger, R. Thorpe, N. Borth, 1998 .

Clinical and Immunobiological Effects of Subcutaneous Recombinant Human Interleukin 12 in Patients with Metastatic Renal Cancer

M. Wadhwa, P. Dilger, R. Thorpe, 2002 .

Testing Plasma Pools for Markers of Viral Contamination: The UK Experience

A. J. Garrett, R. Thorpe, P. Minor, 1996, Vox Sanguinis.

The influence of platelet additive solutions on cytokine levels and complement activation in platelet concentrates during storage

M. Wadhwa, P. Dilger, R. Thorpe, 2003, Vox sanguinis.

Cytokine levels as performance indicators for white blood cell reduction of platelet concentrates

M. Wadhwa, P. Dilger, R. Thorpe, 2002, Vox sanguinis.

Identification of transforming growth factor-beta as a contaminant in factor VIII concentrates: a possible link with immunosuppressive effects in hemophiliacs.

M. Wadhwa, P. Dilger, R. Thorpe, 1994, Blood.

Purification of IgG Using Ion-Exchange HPLC/FPLC

R. Thorpe, M. Page, 1996 .

DETECTION OF PYROGEN BY CYTOKINE RELEASE

R. Thorpe, A. Meager, S. Poole, 1988, The Lancet.

Haematopoietic growth factors and their therapeutic use

M. Wadhwa, R. Thorpe, 2008, Thrombosis and Haemostasis.

The production and purification of PCR-derived recombinant simian immunodeficiency virus p27 gag protein; its use in detecting serological and T-cell responses in macaques.

R. Thorpe, K. Mills, N. Almond, 1990, Journal of virological methods.

Immunogenicity assessment of biotherapeutic products: An overview of assays and their utility.

Ivana Knezevic, Hye-Na Kang, Meenu Wadhwa, 2015, Biologicals : journal of the International Association of Biological Standardization.

Purification of murine monoclonal antibodies.

R. Thorpe, A. Gearing, M. Baines, 1990, Methods in molecular biology.

Quality assessment and its impact on clinical performance of a biosimilar erythropoietin: A simulated case study

Ivana Knezevic, Hye-Na Kang, Robin Thorpe, 2019, Biologicals : journal of the International Association of Biological Standardization.

Current Methods for Detecting Antibodies against Erythropoietin and Other Recombinant Proteins

Robin Thorpe, R. Thorpe, Steven J Swanson, 2005, Clinical Diagnostic Laboratory Immunology.

Alteration of interleukin 2 (IL-2) pharmacokinetics and function by IL-2 antibodies induced after treatment of colorectal carcinoma patients with a combination of monoclonal antibody 17-1A, granulocyte macrophage colony-stimulating factor, and IL-2.

M. Wadhwa, C. Bird, R. Thorpe, 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

Wadhwa , Thorpe : Therapeutic use of haematopoietic growth factors 865 Factors controlling haematopoiesis

M. Wadhwa, R. Thorpe, 2017 .

Association of changes in monocyte antigen presentation and cytokine production in haemophilic boys with treatment and blood‐borne virus infection

M. Wadhwa, R. Thorpe, K. Pasi, 1995, British journal of haematology.

CHAPTER 4 – PRODUCING ANTIBODIES

R. Thorpe, 1994 .

Purification of immunoglobulin g (IgG).

R. Thorpe, M. Baines, 1992, Methods in molecular biology.

Cytokine levels in platelet concentrates: quantitation by bioassays and immunoassays

M. Wadhwa, P. Dilger, C. Bird, 1996, British journal of haematology.

Characterization of complete particles (VSV-G/SIN-GFP) and empty particles (VSV-G/EMPTY) in human immunodeficiency virus type 1-based lentiviral products for gene therapy: potential applications for improvement of product quality and safety.

R. Thorpe, C. Dolman, Yuan Zhao, 2008, Human gene therapy.

Diabetes and cows' milk

R. Thorpe, P. Pozzilli, M. Cavallo, 1996, The Lancet.

Purification of IgG Using Protein A or Protein G

R. Thorpe, M. Page, 1996 .

DEMONSTRATION OF CYTOKINES IN BIOLOGICAL MEDICINES PRODUCED IN MAMMALIAN CELL LINES

M. Wadhwa, C. Bird, R. Thorpe, 1989, The Lancet.

Modulation of the biological activity of thyrotrophin by anti-human thyrotrophin monoclonal antibodies.

S. Nussey, R. Thorpe, A. Taylor, 1990, The Journal of endocrinology.

A systematic approach to the establishment and characterization of endothelial progenitor cells for gene therapy.

R. Thorpe, Yuan Zhao, N. Werling, 2013, Human gene therapy methods.

Batches of intravenous immunoglobulin associated with adverse reactions in recipients contain atypically high anti‐Rh D activity

R. Thorpe, B. Fox, C. Dolman, 2003, Vox sanguinis.

Strategies and Assays for the Assessment of Unwanted Immunogenicity

Meenu Wadhwa, Robin Thorpe, M. Wadhwa, 2006, Journal of immunotoxicology.

Strategies for detection, measurement and characterization of unwanted antibodies induced by therapeutic biologicals.

R Thorpe, M Wadhwa, M. Wadhwa, 2003, Journal of immunological methods.

Immunogenicity of granulocyte-macrophage colony-stimulating factor (GM-CSF) products in patients undergoing combination therapy with GM-CSF.

R Thorpe, M Wadhwa, M. Wadhwa, 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

Production of neutralizing granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) antibodies in carcinoma patients following GM‐CSF combination therapy

J. Fagerberg, M. Wadhwa, C. Bird, 1996, Clinical and experimental immunology.

Anti-A and anti-B activity in batches of different intravenous immunoglobulin products determined using a direct haemagglutination method.

R. Thorpe, B. Fox, C. Dolman, 2005, Biologicals : journal of the International Association of Biological Standardization.

Proteomics analysis of cellular components in lentiviral vector production using Gel‐LC‐MS/MS

R. Thorpe, J. Wheeler, Christopher Jones, 2007, Proteomics. Clinical applications.

Detection and measurement of cytokines.

M. Wadhwa, C. Bird, R. Thorpe, 1992, Blood reviews.

Comparative studies on cellular gene regulation by HIV-1 based vectors: implications for quality control of vector production

R. Thorpe, Y. Zhao, S. Azam, 2005, Gene Therapy.

Treatment of metastatic renal cell carcinoma with subcutaneous interleukin 2: evidence for non-renal clearance of cytokines.

M. Wadhwa, P. Dilger, R. Thorpe, 1997, British Journal of Cancer.

The function of DNA binding protein nucleophosmin in AAV replication

Robin Thorpe, R. Thorpe, Stifani Satkunanathan, 2017, Virology.

Establishment of a novel cell line for the enhanced production of recombinant adeno-associated virus vectors for gene therapy.

R. Thorpe, J. Wheeler, Yuan Zhao, 2014, Human gene therapy.

Interleukin-2 in vivo: production of and response to interleukin-2 in lymphoid organs undergoing a primary immune response to heterologous erythrocytes.

R. Thorpe, A. Gearing, M. Spitz, 1985, Immunology.

Assays for detecting and diagnosing antibody-mediated pure red cell aplasia (PRCA): an assessment of available procedures.

Robin Thorpe, R. Thorpe, Steven J Swanson, 2005, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Production of polyclonal and monoclonal antibodies to human granulocyte colony-stimulating factor (GCSF) and development of immunoassays.

M. Wadhwa, C. Bird, R. Thorpe, 1990, Journal of immunological methods.

International collaborative study to evaluate a candidate reference preparation to define an appropriate specified limit of anti‐D in intravenous immunoglobulin products

A. Heath, R. Thorpe, B. Fox, 2005, Vox sanguinis.

Use of 'single shot' intrasplenic immunization for production of monoclonal antibodies specific for human IgM.

R. Thorpe, A. Gearing, M. Spitz, 1985, Journal of immunological methods.

Single shot intrasplenic immunization: an advantageous procedure for production of monoclonal antibodies specific for human fibrin fragments.

R. Thorpe, P. Gaffney, M. Spitz, 1984, Hybridoma.

Chemokine/chemokine receptor nomenclature.

Osamu Yoshie, Kouji Matsushima, Alberto Mantovani, 2003, Cytokine.

Detection of neutralizing interleukin-17 antibodies in autoimmune polyendocrinopathy syndrome-1 (APS-1) patients using a novel non-cell based electrochemiluminescence assay.

Meenu Wadhwa, Robin Thorpe, M. Wadhwa, 2010, Cytokine.

Multicentre evaluation of stable reference whole blood for enumeration of lymphocyte subsets by flow cytometry.

D. Belgrave, R. Thorpe, G. Janossy, 2005, Cytometry. Part B, Clinical cytometry.

Procoagulant Activity of T Lymphoblastoid Cells in Extrinsic and Intrinsic Coagulation Systems

R. Thorpe, T. Barrowcliffe, A. Hubbard, 1989, Thrombosis and Haemostasis.

Anti-D and anti-i activities are inseparable in V4-34-encoded monoclonal anti-D: the same framework 1 residues are required for both reactivities.

R. Thorpe, C. Ball, B. Fox, 2008, Transfusion.

Anti‐D and anti‐i activities are inseparable in V4‐34‐encoded monoclonal anti‐D: the same framework 1 residues are required for both reactivities

R. Thorpe, C. Ball, B. Fox, 2008 .

The regulatory landscape of biosimilars: WHO efforts and progress made from 2009 to 2019

Shraddha Srivastava, M. Wadhwa, R. Thorpe, 2020, Biologicals : journal of the International Association of Biological Standardization.

WHO/KFDA joint workshop on implementing WHO guidelines on evaluating similar biotherapeutic products, Seoul, Republic of Korea 24-26 August, 2010.

M. Wadhwa, R. Thorpe, I. Knezevic, 2011, Biologicals : journal of the International Association of Biological Standardization.

Use of a standardized MxA protein measurement-based assay for validation of assays for the assessment of neutralizing antibodies against interferon-β.

J. Files, M. Wadhwa, P. Dilger, 2013, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Engineering of the gut commensal bacterium Bacteroides ovatus to produce and secrete biologically active murine interleukin‐2 in response to xylan

P. Dilger, R. Thorpe, S. Carding, 2005, Journal of applied microbiology.

Mechanisms of inhibition of T cell IL‐2 secretion by factor VIII concentrates

M. Wadhwa, P. Dilger, R. Thorpe, 1992, British journal of haematology.

Molecular identity, distribution and heterogeneity of glial fibrillary acidic protein: an immunoblotting and immunohistochemical study of Schwann cells, satellite cells, enteric glia and astrocytes

R. Thorpe, R. Mirsky, K. Jessen, 1984, Journal of neurocytology.

Kinetics of development and characteristics of antibodies induced in cancer patients against yeast expressed rDNA derived granulocyte macrophage colony stimulating factor (GM-CSF).

R Thorpe, M Wadhwa, M. Wadhwa, 2005, Cytokine.

Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T‐cells

L Findlay, R Thorpe, M Wadhwa, 2010, British journal of pharmacology.

Selective cleavage of human IgG by the matrix metalloproteinases, matrilysin and stromelysin.

R. Thorpe, P. Varley, A. Gearing, 2002, Immunology letters.

The effect of primary immunization and concanavalin A on the production of monoclonal natural antibodies.

C. Bird, R. Thorpe, A. Gearing, 1986, Hybridoma.

Characterisation, standardisation and control of therapeutic immunoglobulin preparations intended for intravenous use.

C. Bird, R. Thorpe, M. Brasher, 1987, The Journal of infection.

An antiproliferative bioassay for interleukin-4.

R. Thorpe, A. Mire-Sluis, M. Topp, 1996, Journal of immunological methods.

Production and Characterization of Monoclonal Antibodies to Human Interleukin-12

M. Wadhwa, C. Bird, R. Thorpe, 1997 .

Transforming growth factor-beta 1 blocks interleukin 4 induced cell proliferation by inhibiting a protein tyrosine phosphatase essential for signal transduction.

M. Wadhwa, R. Thorpe, A. Mire-Sluis, 1994, Cytokine.

Surrogate CD16‐expressing effector cell lines for determining the bioactivity of therapeutic monoclonal antibodies

M. Wadhwa, R. Thorpe, J. Derrick, 2017, Journal of pharmaceutical and biomedical analysis.

Reconstitution of interleukin 2 with albumin for infusion

M. Wadhwa, C. Bird, R. Thorpe, 1990, The Lancet.

IL-4 and TNF-alpha-mediated proliferation of the human megakaryocytic line M-O7E is regulated by induced autocrine production of GM-CSF.

M. Wadhwa, P. Dilger, R. Thorpe, 1996, Cytokine.

Systematic Comparison and Validation of Quantitative Real-Time PCR Methods for the Quantitation of Adeno-Associated Viral Products

R. Thorpe, Yuan Zhao, N. Werling, 2015, Human gene therapy methods.

Endothelial cells co-stimulate peripheral blood mononuclear cell responses to monoclonal antibody TGN1412 in culture.

M. Wadhwa, C. Bird, R. Thorpe, 2011, Cytokine.

Improved in vitro methods to predict the in vivo toxicity in man of therapeutic monoclonal antibodies including TGN1412.

R. Thorpe, J. Hood, C. Ball, 2010, Journal of immunological methods.

An anti-cytokine bioactivity assay for interferons-α, -β and -ω

R. Thorpe, A. Mire-Sluis, A. Meager, 1996 .

Safety of biologics, lessons learnt from TGN1412.

R. Thorpe, R. Stebbings, S. Poole, 2009, Current opinion in biotechnology.

M. Wadhwa, R. Thorpe, 2014 .

European perspective on biosimilars.

M. Wadhwa, R. Thorpe, 2013, Bioanalysis.

Terminology for biosimilars – a confusing minefi

M. Wadhwa, R. Thorpe, 2022 .

This information is current as PreClinical Testing of Immunotherapeutics Understanding the Causes to Improve Monoclonal Antibody TGN1412: Better ''Cytokine Storm'' in the Phase I Trial of

M. Wadhwa, R. Thorpe, L. Findlay, 2013 .

Hepatitis A virus concentrations in immunoglobulin preparations

R. Thorpe, P. Minor, David Wood, 1991, The Lancet.

Purification of IgG Using Caprylic Acid

R. Thorpe, M. Page, 1996 .

Immunological standardization Implications for the assay and biological activity of interleukin-4 Results of a WHO international collaborative study

R. G. Das, R. Thorpe, A. Mire-Sluis, 1996 .

Development of immunoassays for human interleukin 3 and interleukin 4, some of which discriminate between different recombinant DNA-derived molecules.

M. Wadhwa, C. Bird, R. Thorpe, 1991, Cytokine.

Interleukin-4 proliferative signal transduction involves the activation of a tyrosine-specific phosphatase and the dephosphorylation of an 80-kDa protein.

R. Thorpe, A. Mire-Sluis, 1991, The Journal of biological chemistry.

Failure to detect antibodies to HIV-1 in sera from patients with mycobacterial infections.

R. Thorpe, M. Malkovsky, P. Dilqer, 1989, International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association.

Quantitative cell line based bioassays for human cytokines.

R. Thorpe, A. Mire-Sluis, L. Page, 1995, Journal of immunological methods.

An assessment of biological potency and molecular characteristics of different innovator and noninnovator interferon-beta products.

M. Wadhwa, P. Dilger, C. Bird, 2011, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

An evaluation of the stability of granulocyte colony stimulating factor on short-term storage and delivery from an elastomeric infusion system

R. Thorpe, A. Mire-Sluis, H. Tivnann, 1996 .

Bioanalytical strategies in determining immunogenicity.

M. Wadhwa, R. Thorpe, 2019, Bioanalysis.

Anti–Rh D Activity of Commercial Intravenous Immunoglobulin Preparations

R. Thorpe, S. Thorpe, C. Turner, 1999, Vox Sanguinis.

The international standard for human interleukin-2. Calibration by international collaborative study.

R. Thorpe, A. Gearing, 1988, Journal of immunological methods.

The use of bioassays for the characterisation and control of biological therapeutic products produced by biotechnology.

R Thorpe, M Wadhwa, A Mire-Sluis, 1997, Developments in biological standardization.

Assay of pyrogenic contamination in pharmaceuticals by cytokine release from monocytes.

R. Thorpe, A. Meager, A. Gearing, 1988, Developments in biological standardization.

In support of the European Union biosimilar framework

R. Thorpe, N. Ekman, C. Schneider, 2012, Nature Biotechnology.

Taking immunogenicity assessment of therapeutic proteins to the next level.

R Seitz, R Thorpe, A Mire-Sluis, 2011, Biologicals : journal of the International Association of Biological Standardization.

Report on a Collaborative study for proposed 1 st International standard for PEGylated G-CSF (PEG-G-CSF)

M. Wadhwa, C. Bird, R. Thorpe, 2013 .

The 2nd International Standard for human granulocyte colony stimulating factor.

M. Wadhwa, M. Hamill, C. Bird, 2011, Journal of immunological methods.

Identification of transforming growth factor-beta as a contaminant in factor VIII concentrates: a possible link with immunosuppressive effects in hemophiliacs

M. Wadhwa, P. Dilger, R. Thorpe, 1994 .

The Nonclinical Evaluation of Biotechnology‐Derived Pharmaceuticals, Moving on after the TeGenero Case*

R. Thorpe, C. Herberts, R. Stebbings, 2014 .

How predictive are in vitro assays for cytokine release syndrome in vivo? A comparison of methods reveals worrying differences in sensitivity and frequency of response.

R. Thorpe, R. Stebbings, L. Findlay, 2013, Cytokine.

Mass spectrometry analysis reveals differences in the host cell protein species found in pseudotyped lentiviral vectors

R. Thorpe, Y. Takeuchi, M. Collins, 2018, Biologicals : journal of the International Association of Biological Standardization.

Are neutralizing anti-GM-CSF autoantibodies present in all healthy persons?

M. Wadhwa, R. Thorpe, A. Meager, 2010, Blood.

Purification of monoclonal antibodies.

R. Thorpe, M. Page, 1998, Methods in molecular biology.

Cytokines as quality indicators of leucoreduced red cell concentrates.

M. Wadhwa, P. Dilger, R. Thorpe, 2002, Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.

Influence of Escherichia coli chaperone DnaK on protein immunogenicity

M. Wadhwa, R. Thorpe, J. Derrick, 2016, Immunology.

The use of monoclonal antibodies raised against a human IgE myeloma paraprotein for the study of allergen extracts and sera from allergic patients.

C. Bird, R. Thorpe, L. Alterman, 1987, Clinical and experimental immunology.

Antibody to hepatitis C virus in plasma pools

R. Thorpe, P. Minor, P. Pipkin, 1990, The Lancet.

The international standard for granulocyte-macrophage colony stimulating factor (GM-CSF). Evaluation in an international collaborative study. Participants of the Collaborative Study.

R. G. Das, R. Thorpe, A. Mire-Sluis, 1995, Journal of immunological methods.

Antibody C Region Influences TGN1412-like Functional Activity In Vitro

P. Parren, R. Thorpe, C. Ball, 2012, The Journal of Immunology.

Production and characterization of monoclonal antibodies to beta-galactoside-binding lectin of bovine heart muscle. Direct evidence that haemagglutinating activity is associated with a 13kDa protein.

R. Thorpe, S. Carding, M. Spitz, 1984, The Biochemical journal.

Immunoassays for detecting cytokines: what are they really measuring?

R Thorpe, R. Thorpe, A. Mire-Sluis, 1995, Journal of immunological methods.

Guidance on Immunogenicity Assessment of Biologically Derived Therapeutic Proteins: A European Perspective

M. Wadhwa, R. Thorpe, 2011 .

Neutralizing antibodies to granulocyte-macrophage colony-stimulating factor, interleukin-1alpha and interferon-alpha but not other cytokines in human immunoglobulin preparations.

R. G. Das, M. Wadhwa, P. Dilger, 2000, Immunology.

Development of a Lyophilization Formulation that Preserves the Biological Activity of the Platelet‐inducing Cytokine Interleukin‐11 at Low Concentrations

R. Thorpe, A. Mire-Sluis, Christopher Page, 2000, The Journal of pharmacy and pharmacology.

Antibodies to Bovine Beta-Casein in Diabetes and Other Autoimmune Diseases

R. Thorpe, P. Pozzilli, S. Manfrini, 2002, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Chemokine/Chemokine Receptor Nomenclature∗

M. Wadhwa, R. Thorpe, A. Mantovani, 2001, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

The challenges of immunogenicity in developing biosimilar products.

M. Wadhwa, R. Thorpe, 2009, IDrugs : the investigational drugs journal.

Spontaneously occurring neutralizing antibodies against granulocyte–macrophage colony‐stimulating factor in patients with autoimmune disease

Willcox, M. Wadhwa, P. Dilger, 1999, Immunology.

Factor VIII concentrates and the immune system--laboratory investigations.

M. Wadhwa, R. Thorpe, A. Mire-Sluis, 1995, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

Enhanced efficacy of anti-D immunoglobulin for treating ITP is not explained by higher immunoglobulin polymer content.

R. Thorpe, C. Dolman, S. Thorpe, 2001, Biologicals : journal of the International Association of Biological Standardization.

Reply to the Response from Babette Wolf et al. to our Letter to the Editor: How predictive are in vitro assays for cytokine release syndrome in vivo? A comparison of methods reveals worrying differences in sensitivity and frequency of response

R. Thorpe, R. Stebbings, L. Findlay, 2013 .

ENGLISH ONLY EXPERT COMMITTEE ON BIOLOGICAL STANDARDIZATION Geneva , 15 to 19 October 2012 Report on a Collaborative study for proposed 2 nd International standard for Interleukin-2 ( IL-2 )

M. Wadhwa, C. Bird, A. Heath, 2012 .