N. Heisterkamp

N. Heisterkamp, J. Groffen, E. Romppanen, 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Cell-Intrinsic and Extrinsic Effects of Galectin-1 and Galectin-3 in B-Cell Precursor Acute Lymphoblastic Leukemia

N. Heisterkamp, J. Groffen, E. Joo, 2021, bioRxiv.

Protein kinase CKIIα interacts with the Bcr moiety of Bcr/Abl and mediates proliferation of Bcr/Abl-expressing cells

N. Heisterkamp, J. Groffen, J. Cunnick, 2003, Oncogene.

Tyrosine 207 in CRKL is the BCR/ABL phosphorylation site

N. Heisterkamp, J. Groffen, R. D. Jong, 1997, Oncogene.

Multi-Faceted Effects of ST6Gal1 Expression on Precursor B-Lineage Acute Lymphoblastic Leukemia

Mingfeng Zhang, N. Heisterkamp, D. Kolarich, 2022, Frontiers in Oncology.

Philadelphia-positive leukemia Entire ABL gene is joined with 5'-BCR in some patients with

N. Heisterkamp, J. Groffen, C. Morris, 2011 .

Cellular interactions of CRKL, and SH2-SH3 adaptor protein.

T. Fioretos, V. Kaartinen, J. Voncken, 1994, Cancer research.

t-Induced Obesity Accelerates Acute Lymphoblastic Pr R kemia Progression in Two Murine Models

N. Heisterkamp, J. Groffen, S. Mittelman, 2010 .

The human gamma-glutamyltransferase gene family

Tam P. Sneddon, D. Warburton, N. Heisterkamp, 2008, Human Genetics.

Cloning and nucleotide sequence of human gamma-glutamyl transpeptidase.

N. Heisterkamp, J. Groffen, E. Rajpert-De Meyts, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Oncogene activation by chromosomal translocation in chronic myelocytic leukemia.

N. Heisterkamp, J. Groffen, K. Stam, 1986, Cold Spring Harbor symposia on quantitative biology.

The chronic myelocytic cell line K562 contains a breakpoint in bcr and produces a chimeric bcr/c-abl transcript

N. Heisterkamp, J. Groffen, G. Grosveld, 1986, Molecular and cellular biology.

Duplication of the bcr and gamma-glutamyl transpeptidase genes.

N. Heisterkamp, J. Groffen, 1988, Nucleic Acids Research.

TGF-beta3-induced palatogenesis requires matrix metalloproteinases.

V. Kaartinen, N. Heisterkamp, J. Groffen, 2001, Molecular biology of the cell.

Comparison of baculovirus-expressed c-Abl and BCR/ABL protein tyrosine kinases.

N. Heisterkamp, J. Groffen, C. Reynolds, 1993, Biochimica et biophysica acta.

The BCR/ABL hybrid gene.

N. Heisterkamp, J. Groffen, 1987, Bailliere's clinical haematology.

c-sis is translocated from chromosome 22 to chromosome 9 in chronic myelocytic leukemia

J. Stephenson, N. Heisterkamp, J. Groffen, 1983, The Journal of experimental medicine.

Homology between phosphotyrosine acceptor site of human c-abl and viral oncogene products

J. Stephenson, N. Heisterkamp, J. Groffen, 1983, Nature.

Genetic analysis of the 15;17 chromosome translocation associated with acute promyelocytic leukemia.

J. Stephenson, S. Povey, N. Heisterkamp, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Localization of the human c-sis oncogene in Ph1-positive and Ph1- negative chronic myelocytic leukemia by in situ hybridization

A. Hagemeijer, N. Heisterkamp, J. Groffen, 1984 .

Expression of the chronic myelogenous leukemia-associated p210bcr/abl oncoprotein in a murine IL-3 dependent myeloid cell line.

N. Heisterkamp, J. Groffen, P. Laneuville, 1991, Oncogene.

A functional receptor for B-cell-activating factor is expressed on human acute lymphoblastic leukemias.

N. Heisterkamp, J. Groffen, M. Müschen, 2010, Cancer research.

Pre-B acute lymphoblastic leukemia expresses cell surface nucleolin as a 9-O-acetylated sialoglycoprotein

N. Heisterkamp, J. Groffen, C. Parrish, 2018, Scientific Reports.

Humanbcr-abl gene has a lethal effect on embryogenesis

D. Kioussis, G. Jenster, N. Heisterkamp, 1991, Transgenic Research.

Restricted oncogenicity of BCR/ABL p190 in transgenic mice.

M. Greaves, J. Voncken, N. Heisterkamp, 1992, Cancer research.

A novel abl protein expressed in Philadelphia chromosome positive acute lymphoblastic leukaemia positive acute lymphoblastic leukaemia

M. Greaves, M. Greaves, N. Heisterkamp, 1987, Nature.

Entire ABL gene is joined with 5'-BCR in some patients with Philadelphia-positive leukemia.

N. Heisterkamp, J. Groffen, C. Morris, 1991, Blood.

Expression of multiple gamma-glutamyltransferase genes in man.

G. Siest, N. Heisterkamp, J. Groffen, 1994, The Biochemical journal.

Development of resistance to dasatinib in Bcr/Abl-positive acute lymphoblastic leukemia

N. Heisterkamp, J. Groffen, M. Müschen, 2010, Leukemia.

A mouse model for the human lysosomal disease aspartylglycosaminuria

V. Kaartinen, J. Voncken, N. Heisterkamp, 1996, Nature Medicine.

O-acetylated N-acetylneuraminic acid as a novel target for therapy in human pre-B acute lymphoblastic leukemia

N. Heisterkamp, J. Groffen, Kam Y. Lau, 2013, The Journal of experimental medicine.

Crkl Is Complexed with Tyrosine-phosphorylated Cbl in Ph-positive Leukemia (*)

N. Heisterkamp, J. Groffen, R. de Jong, 1995, The Journal of Biological Chemistry.

The human v-abl cellular homologue.

J. Stephenson, N. Heisterkamp, J. Groffen, 1983, Journal of molecular and applied genetics.

Analysis of acute lymphoblastic leukemia drug sensitivity by changes in impedance via stromal cell adherence

N. Heisterkamp, F. Cerignoli, Y. Abassi, 2021, PloS one.

Effector-Mediated Eradication of Precursor B Acute Lymphoblastic Leukemia with a Novel Fc-Engineered Monoclonal Antibody Targeting the BAFF-R

N. Heisterkamp, J. Groffen, M. Mclaughlin, 2014, Molecular Cancer Therapeutics.

Localization of the human c-sis oncogene in Ph1-positive and Ph1-negative chronic myelocytic leukemia by in situ hybridization.

A. Hagemeijer, N. Heisterkamp, J. Groffen, 1984, Blood.

Clonal characteristics of acute lymphoblastic cells derived from BCR/ABL p190 transgenic mice.

M. Greaves, J. Voncken, N. Heisterkamp, 1992, Oncogene.

Activity of the Aurora Kinase Inhibitor VX-680 against Bcr/Abl-Positive Acute Lymphoblastic Leukemias

N. Heisterkamp, J. Groffen, F. Fei, 2010, Molecular Cancer Therapeutics.

Quantitative measure of c-abl and p15 methylation in chronic myelogenous leukemia: biological implications.

N. Heisterkamp, J. Groffen, M. Lübbert, 2000, Blood.

Treatment of human pre-B acute lymphoblastic leukemia with the Aurora kinase inhibitor PHA-739358 (Danusertib)

N. Heisterkamp, J. Groffen, J. Moll, 2012, Molecular Cancer.

Evidence that the phl gene encodes a 160,000-dalton phosphoprotein with associated kinase activity.

N. Heisterkamp, J. Groffen, F. Reynolds, 1987, Molecular and cellular biology.

Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia.

M. Loh, M. Kahn, N. Heisterkamp, 2011, Blood.

CRK proto-oncogene maps to human chromosome band 17p13.

T. Fioretos, N. Heisterkamp, J. Groffen, 1993, Oncogene.

The Role of the Ph Chromosome in Chronic Myelocytic Leukemia

N. Heisterkamp, J. Groffen, G. Grosveld, 1987 .

Breakpoint Analysis in CML: Potentials for Detection of Minimal Residual Disease

N. Heisterkamp, J. Groffen, G. Grosveld, 1986 .

Enzyme replacement therapy in a mouse model of aspartylglycosaminuria

V. Kosma, V. Kaartinen, N. Heisterkamp, 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

How to avoid being eaten: a lymphoma's defense.

N. Heisterkamp, 2016, Blood.

Spatial organization of ABR and CRK genes on human chromosome band 17p13.3.

D. Ledbetter, N. Heisterkamp, J. Groffen, 1995, Oncogene.

Regional localization and developmental expression of the BCR gene in rodent brain.

F. Kamme, T. Fioretos, J. Voncken, 1995, Cellular & molecular biology research.

The FER gene is evolutionarily conserved and encodes a widely expressed member of the FPS/FES protein-tyrosine kinase family

T. Pawson, N. Heisterkamp, J. Groffen, 1989, Molecular and cellular biology.

bcr/c-abl transcript. a breakpoint in bcr and produces a chimeric The chronic myelocytic cell line K562 contains

N. Heisterkamp, J. Groffen, G. Grosveld, 2013 .

TheChronic Myelocytic CellLineK562Contains aBreakpoint in bcrandProduces aChimeric bcrlc-abl Transcript

N. Heisterkamp, T. Verwoerd, Ton Vanagthoven, 1986 .

p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction.

N. Heisterkamp, M. Duñach, H. Pálmer, 2003, Molecular and cellular biology.

BCL6-Mediated Survival Signaling Promotes Drug-Resistance in BCRABL1- Driven Acute Lymphoblastic Leukemia

A. Melnick, N. Heisterkamp, W. Hofmann, 2008 .

Treatment of acute lymphoblastic leukemia with an rGel/BLyS fusion toxin

N. Heisterkamp, J. Groffen, M. Rosenblum, 2012, Leukemia.

Potential of autologous NK cell therapy to eradicate leukemia

N. Heisterkamp, H. Abdel-Azim, 2015, Oncoimmunology.

Galectin-1 and Galectin-3 in B-Cell Precursor Acute Lymphoblastic Leukemia

Mingfeng Zhang, N. Heisterkamp, E. Joo, 2022, International journal of molecular sciences.

Overcoming Microenvironment-Mediated Chemoprotection through Stromal Galectin-3 Inhibition in Acute Lymphoblastic Leukemia

N. Heisterkamp, K. Bum-Erdene, M. Itzstein, 2021, bioRxiv.

The PI3Kδ Inhibitor Idelalisib Inhibits Homing in an in Vitro and in Vivo Model of B ALL

N. Heisterkamp, M. Konopleva, D. Bhojwani, 2017, Cancers.

C‐abl and bcr are rearranged in a Ph1‐negative CML patient.

N. Heisterkamp, J. Groffen, C. Bartram, 1985, The EMBO journal.

Bcr / Abl P 190 interaction with Spa-1 , a GTPase activating protein for the small GTPase Rap 1

N. Heisterkamp, J. Groffen, Hyung-Taek Lee, 2022 .

Unique fusion of bcr and c-abl genes in Philadelphia chromosome positive acute lymphoblastic leukemia

N. Heisterkamp, J. Groffen, G. Grosveld, 1987, Cell.

No evidence for genomic imprinting of the human BCR gene.

T. Fioretos, N. Heisterkamp, J. Groffen, 1994, Blood.

The bcr Gene in Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia

S. Thibodeau, N. Heisterkamp, J. Groffen, 1989 .

Molecular analysis of chromosome breakpoints.

N. Heisterkamp, J. Groffen, G. Grosveld, 1989, Progress in nucleic acid research and molecular biology.

The bcr gene in Philadelphia chromosome positive acute lymphoblastic leukemia.

S. Thibodeau, N. Heisterkamp, J. Groffen, 1989, Blood.

Cell type–specific expression of adenomatous polyposis coli in lung development, injury, and repair

N. Heisterkamp, J. Groffen, P. Minoo, 2010, Developmental dynamics : an official publication of the American Association of Anatomists.

Localization of the human mitochondrial citrate transporter protein gene to chromosome 22Q11 in the DiGeorge syndrome critical region.

B. Roe, N. Heisterkamp, J. Groffen, 1995, Genomics.

BCL6 enables Ph+ acute lymphoblastic leukemia cells to survive BCR-ABL1 kinase inhibition

Sebastian Herzog, Hong Wu, Eugene Park, 2011, Nature.

Treatment of B-cell precursor acute lymphoblastic leukemia with the Galectin-1 inhibitor PTX008

N. Heisterkamp, J. Groffen, K. Mayo, 2018, Journal of experimental & clinical cancer research : CR.

Targeting interactions between the Galectin-3 intrinsically disordered and structured domains based on long time-scale accelerated molecular dynamics

Mingfeng Zhang, N. Heisterkamp, Weidong Hu, 2021, bioRxiv.

Glycoproteome remodeling in MLL-rearranged B-cell precursor acute lymphoblastic leukemia

Mingfeng Zhang, N. Heisterkamp, N. Packer, 2021, Theranostics.

Multi-omics of MLL-rearranged B-cell precursor acute lymphoblastic leukemia reveals broad glycoproteome remodelling

Mingfeng Zhang, N. Heisterkamp, N. Packer, 2021, medRxiv.

B-cell precursor acute lymphoblastic leukemia and stromal cells communicate through Galectin-3

M. Fabbri, N. Heisterkamp, J. Groffen, 2015, Oncotarget.

Galectin-3 in pre-B acute lymphoblastic leukemia

N. Heisterkamp, J. Groffen, M. Itzstein, 2013, Leukemia.

Integrin alpha4 blockade sensitizes drug resistant pre-B acute lymphoblastic leukemia to chemotherapy.

M. Loh, N. Heisterkamp, H. Koo, 2013, Blood.

Combination of drug therapy in acute lymphoblastic leukemia with a CXCR4 antagonist

N. Heisterkamp, J. Groffen, Min Yu, 2011, Leukemia.

TGFβ signaling plays a critical role in promoting alternative macrophage activation

N. Heisterkamp, J. Groffen, S. Yi, 2012, BMC Immunology.

Nucleotide sequence of both reciprocal translocation junction regions in a patient with Ph positive acute lymphoblastic leukaemia, with a breakpoint within the first intron of the BCR gene.

N. Heisterkamp, J. Groffen, L. Wiedemann, 1989, Nucleic acids research.

Rearrangement of the human ABL oncogene in a glioblastoma.

N. Heisterkamp, J. Groffen, C. Morris, 1990, Cancer research.

Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22

J. Stephenson, N. Heisterkamp, J. Groffen, 1984, Cell.

A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia

J. Stephenson, A. Hagemeijer, N. Heisterkamp, 1982, Nature.

Identification of a human gamma-glutamyl cleaving enzyme related to, but distinct from, gamma-glutamyl transpeptidase.

N. Heisterkamp, J. Groffen, H. Forman, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Sprouty2 downregulation plays a pivotal role in mediating crosstalk between TGF‐β1 signaling and EGF as well as FGF receptor tyrosine kinase‐ERK pathways in mesenchymal cells

D. Warburton, N. Heisterkamp, J. Groffen, 2007, Journal of cellular physiology.

Characterization of RAC3, a Novel Member of the Rho Family*

N. Heisterkamp, J. Groffen, L. Haataja, 1997, The Journal of Biological Chemistry.

Structural organization of the bcr gene and its role in the Ph′ translocation

Kees Stam, N. Heisterkamp, J. Groffen, 1985, Nature.

Acute leukaemia in bcr/abl transgenic mice

G. Jenster, N. Heisterkamp, J. Groffen, 1990, Nature.

Localization of the c-abl oncogene adjacent to a translocation break point in chronic myelocytic leukaemia

J. Stephenson, N. Heisterkamp, J. Groffen, 1983, Nature.

Unique organization of the human BCR gene promoter.

N. Heisterkamp, J. Groffen, Q. Zhu, 1990, Nucleic acids research.

Clonal development and karyotype evolution during leukemogenesis of BCR/ABL transgenic mice.

J. Voncken, N. Heisterkamp, J. Groffen, 1992, Blood.

The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia.

M. Lieber, N. Heisterkamp, J. Groffen, 2009, Cancer cell.

Philadelphia-positive leukemia: a personal perspective

N. Heisterkamp, J. Groffen, 2002, Oncogene.

Translocation of c-abl oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia

J. Stephenson, A. Hagemeijer, M. Ferguson-Smith, 1983, Nature.

BCR/ABL P190 transgenic mice develop leukemia in the absence of Crkl

V. Kaartinen, N. Heisterkamp, J. Groffen, 2002, Oncogene.

Crkl enhances leukemogenesis in BCR/ABL P190 transgenic mice.

V. Kaartinen, N. Heisterkamp, J. Groffen, 2001, Cancer research.

BCR/ABL-induced Leukemogenesis Causes Phosphorylation of Hef1 and Its Association with Crkl*

N. Heisterkamp, J. Groffen, R. de Jong, 1997, The Journal of Biological Chemistry.

CRKL Links p210BCR/ABL with Paxillin in Chronic Myelogenous Leukemia Cells (*)

N. Heisterkamp, J. Groffen, R. Salgia, 1995, The Journal of Biological Chemistry.

Tyrosine phosphorylation of murine Crkl.

J. Voncken, N. Heisterkamp, J. Groffen, 1995, Oncogene.

TGF-β3-induced Palatogenesis Requires Matrix Metalloproteinases

V. Kaartinen, N. Heisterkamp, J. Groffen, 2001 .

A complex chromosome rearrangement forms the BCR‐ABL fusion gene in leukemic cells with a normal karyotype

N. Heisterkamp, J. Groffen, C. Morris, 1991, Genes, chromosomes & cancer.

Increased neutrophil respiratory burst in bcr-null mutants

V. Kaartinen, J. Voncken, N. Heisterkamp, 1995, Cell.

Tyrosine phosphorylation of P160 BCR by P210 BCR-ABL.

M. Campbell, N. Heisterkamp, J. Groffen, 1993, Blood.

N. Heisterkamp, 2022 .

Inhibition of Bcr serine kinase by tyrosine phosphorylation

N. Heisterkamp, J. Groffen, Y. Wu, 1996, Molecular and cellular biology.

The Bcr N-terminal oligomerization domain contributes to the full oncogenicity of P190 Bcr/Abl in transgenic mice.

J. Voncken, N. Heisterkamp, J. Groffen, 2001, International journal of molecular medicine.

Chromosomal localization of human cellular homologues of two viral oncogenes

P. Goodfellow, J. Stephenson, W. Bodmer, 1982, Nature.

Targeted Expression of Activated Rac3 in Mammary Epithelium Leads to Defective Postlactational Involution and Benign Mammary Gland Lesions

V. Kaartinen, N. Heisterkamp, J. Groffen, 2003, Cells Tissues Organs.

The small GTPase RAC3 gene is located within chromosome band 17q25.3 outside and telomeric of a region commonly deleted in breast and ovarian tumours

N. Heisterkamp, J. Groffen, C. Morris, 2000, Cytogenetic and Genome Research.

Treatment of P190 Bcr/Abl lymphoblastic leukemia cells with inhibitors of the serine/threonine kinase CK2

N. Heisterkamp, J. Groffen, H. Shimada, 2007, Leukemia.

Generation of rac3 Null Mutant Mice: Role of Rac3 in Bcr/Abl-Caused Lymphoblastic Leukemia

V. Kaartinen, N. Heisterkamp, J. Groffen, 2005, Molecular and Cellular Biology.

A genetic linkage map of mouse chromosome 10: localization of eighteen molecular markers using a single interspecific backcross.

M. Justice, N. Copeland, D. Gilbert, 1990, Genetics.

Abnormal function of astroglia lacking Abr and Bcr RacGAPs.

V. Kaartinen, J. Voncken, N. Heisterkamp, 2001, Development.

Interaction of Bcr/Abl with C3G, an exchange factor for the small GTPase Rap1, through the adapter protein Crkl.

N. Heisterkamp, J. Groffen, Y. Cho, 2005, Biochemical and biophysical research communications.

Novel Selective Galectin-3 Antagonists Are Cytotoxic to Acute Lymphoblastic Leukemia.

N. Heisterkamp, J. Groffen, K. Bum-Erdene, 2022, Journal of medicinal chemistry.

Adipocytes impair leukemia treatment in mice.

N. Heisterkamp, A. S. Moses, S. Mittelman, 2009, Cancer research.

Pre–B cell receptor–mediated cell cycle arrest in Philadelphia chromosome–positive acute lymphoblastic leukemia requires IKAROS function

N. Heisterkamp, J. Groffen, H. Jäck, 2009, The Journal of experimental medicine.

Transglutaminase 2 Regulates the GTPase-activating Activity of Bcr*

N. Heisterkamp, J. Groffen, S. Yi, 2009, The Journal of Biological Chemistry.

C3G is tyrosine-phosphorylated after integrin-mediated cell adhesion in normal but not in Bcr/Abl expressing cells

N. Heisterkamp, J. Groffen, R. D. Jong, 1998, Oncogene.

Oncogenes Involved in Chronic Myelocytic Leukemia

J. Stephenson, N. Heisterkamp, J. Groffen, 1985 .

The Role of the Philadelphia Translocation in Chronic Myelocytic Leukemia

N. Heisterkamp, J. Groffen, G. Grosveld, 1987, Annals of clinical research.

Bcr is a substrate for Transglutaminase 2 cross-linking activity

N. Heisterkamp, J. Groffen, S. Yi, 2011, BMC Biochemistry.

Environment-mediated drug resistance in Bcr/Abl-positive acute lymphoblastic leukemia

N. Heisterkamp, J. Groffen, S. Yi, 2012, Oncoimmunology.

Leukemic kinases of the Abl family − an update

S. Feller, N. Heisterkamp, J. Groffen, 2001 .

Differential Interaction of Crkl with Cbl or C3G, Hef-1, and γ Subunit Immunoreceptor Tyrosine-Based Activation Motif in Signaling of Myeloid High Affinity Fc Receptor for IgG (FcγRI)

N. Heisterkamp, J. Groffen, D. Durden, 1998, The Journal of Immunology.

The Small GTPase Rac3 Interacts with the Integrin-binding Protein CIB and Promotes Integrin αIIbβ3-mediated Adhesion and Spreading*

V. Kaartinen, N. Heisterkamp, J. Groffen, 2002, The Journal of Biological Chemistry.

Progressive neurodegeneration in aspartylglycosaminuria mice.

V. Kaartinen, N. Heisterkamp, J. Groffen, 1998, The American journal of pathology.

Animal Model Progressive Neurodegeneration in Aspartylglycosaminuria Mice

V. Kaartinen, N. Heisterkamp, J. Groffen, 1998 .

Molecular analysis of both translocation products of a Philadelphia-positive CML patient.

N. Heisterkamp, J. Groffen, T. Agthoven, 1986, Nucleic acids research.

Transforming growth factor‐β3 regulates transdifferentiation of medial edge epithelium during palatal fusion and associated degradation of the basement membrane

V. Kaartinen, C. Shuler, N. Heisterkamp, 1997, Developmental dynamics : an official publication of the American Association of Anatomists.

Transfection with gamma-glutamyl transpeptidase enhances recovery from glutathione depletion using extracellular glutathione.

N. Heisterkamp, J. Groffen, H. Forman, 1992, Toxicology and applied pharmacology.

TGF-beta3-null mutation does not abrogate fetal lung maturation in vivo by glucocorticoids.

V. Kaartinen, D. Warburton, N. Heisterkamp, 1999, The American journal of physiology.

TGF-b 3-null mutation does not abrogate fetal lung maturation in vivo by glucocorticoids

V. Kaartinen, D. Warburton, N. Heisterkamp, 1999 .

Developmental partitioning of SYK and ZAP70 prevents autoimmunity and cancer.

W. Chan, A. Pandey, N. Heisterkamp, 2021, Molecular cell.

Localization of the TRK proto-oncogene to human chromosome bands 1q23-1q24.

N. Heisterkamp, J. Groffen, C. Morris, 1991, Oncogene.

Drug-tolerant persister B-cell precursor acute lymphoblastic leukemia cells

Mingfeng Zhang, N. Heisterkamp, Lu Yang, 2023, bioRxiv.

Bcr/Abl associated leukemogenesis in bcr null mutant mice

V. Kaartinen, J. Voncken, N. Heisterkamp, 1998, Oncogene.

TNF-alpha represses transcription of human Bone Morphogenetic Protein-4 in lung epithelial cells.

D. Warburton, N. Heisterkamp, S. Bellusci, 2007, Gene.

Expression of cassini, a murine gamma-satellite sequence conserved in evolution, is regulated in normal and malignant hematopoietic cells

N. Heisterkamp, J. Groffen, S. Yi, 2012, BMC Genomics.

Isolation and sequence analysis of a novel human tyrosine kinase gene

N. Heisterkamp, J. Groffen, Q. Hao, 1989, Molecular and cellular biology.

Ph-negative chronic myeloid leukemia: molecular analysis of ABL insertion into M-BCR on chromosome 22.

N. Heisterkamp, J. Groffen, C. Morris, 1990, Blood.

A farnesyltransferase inhibitor increases survival of mice with very advanced stage acute lymphoblastic leukemia/lymphoma caused by P190 Bcr/Abl

N. Heisterkamp, J. Groffen, B. Zhang, 2004, Leukemia.

Regulation of dendritic arborization by BCR Rac1 GTPase-activating protein, a substrate of PTPRT

N. Heisterkamp, Eunjoon Kim, Sung Goo Park, 2012, Journal of Cell Science.

Isolation of NotI sites from chromosome 22q11.

A. Poustka, N. Heisterkamp, J. Groffen, 1993, Genomics.

Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family.

G M Bokoch, V. Kaartinen, N. Heisterkamp, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Characterization of the human ABL promoter regions.

N. Heisterkamp, J. Groffen, Q. Zhu, 1990, Oncogene.

Involvement of the Tyrosine Kinase Fer in Cell Adhesion

N. Heisterkamp, J. Groffen, R. Rosato, 1998, Molecular and Cellular Biology.

Lack of Bcr and Abr Promotes Hypoxia-Induced Pulmonary Hypertension in Mice

N. Heisterkamp, J. Groffen, Min Yu, 2012, PloS one.

Regulation of Synaptic Rac1 Activity, Long-Term Potentiation Maintenance, and Learning and Memory by BCR and ABR Rac GTPase-Activating Proteins

N. Heisterkamp, J. Groffen, Y. Bae, 2010, The Journal of Neuroscience.

Characterization of the fate of midline epithelial cells during the fusion of mandibular prominences in vivo

V. Kaartinen, C. Shuler, N. Heisterkamp, 1997, Developmental dynamics : an official publication of the American Association of Anatomists.

Scambio, a novel guanine nucleotide exchange factor for Rho

N. Heisterkamp, J. Groffen, B. Hemmeryckx, 2004, Molecular Cancer.

Differential expression of TGF-β isoforms during postlactational mammary gland involution

V. Kaartinen, N. Heisterkamp, J. Groffen, 2000, Cell and Tissue Research.

Abr, a Negative Regulator of Rac, Attenuates Cockroach Allergen–Induced Asthma in a Mouse Model

N. Heisterkamp, J. Groffen, F. Fei, 2013, The Journal of Immunology.

Negative cooperativity in the insulin-like growth factor-I receptor and a chimeric IGF-I/insulin receptor.

C. Christoffersen, N. Heisterkamp, J. Groffen, 1994, Endocrinology.

Philadelphia-negative chronic myelogenous leukemia in a patient with a unique complex translocation: 46,XY,t(9;12;15)(q34;12;q21).

N. Heisterkamp, J. Groffen, A. Shanske, 1998, Leukemia research.

phosphorylation.of Bcr serine kinase by tyrosine

N. Heisterkamp, J. Groffen, Yun Wu, 2013 .

Evidence that the phl gene encodes a 160,000-dalton phosphoprotein with associated kinase activity

N. Heisterkamp, J. Groffen, F. Reynolds, 1987 .

Targeting CD19-negative relapsed B-acute lymphoblastic leukemia using trivalent CAR T cells.

M. Baker, N. Heisterkamp, N. Varadarajan, 2018 .

Bcr/Abl P190 interaction with Spa-1, a GTPase activating protein for the small GTPase Rap1.

N. Heisterkamp, J. Groffen, S. Yi, 2008, International journal of molecular medicine.

Human ABR encodes a protein with GAPrac activity and homology to the DBL nucleotide exchange factor domain.

V. Kaartinen, N. Heisterkamp, J. Groffen, 1993, The Journal of biological chemistry.

AMD3100 sensitizes acute lymphoblastic leukemia cells to chemotherapy in vivo

N. Heisterkamp, J. Groffen, A. Yang, 2011, Blood cancer journal.

Treatment of B-cell precursor acute lymphoblastic leukemia with the Galectin-1 inhibitor PTX008

N. Heisterkamp, J. Groffen, K. Mayo, 2018, Journal of experimental & clinical cancer research : CR.

Protein kinase CKIIa interacts with the Bcr moiety of Bcr/Abl and mediates proliferation of Bcr/Abl-expressing cells

N. Heisterkamp, J. Groffen, J. Cunnick, 2004, Oncogene.

The chimeric BCR-ABL gene.

N. Heisterkamp, J. Groffen, 1997, Bailliere's clinical haematology.

Increased resistance to a farnesyltransferase inhibitor by N-cadherin expression in Bcr/Abl-P190 lymphoblastic leukemia cells

N. Heisterkamp, J. Groffen, B. Zhang, 2007, Leukemia.

Role of Survivin in Drug Resistant B-Cell Acute Lymphoblastic Leukemia.

C. Nguyên, M. Kahn, N. Heisterkamp, 2009 .

Bcr and Abr Cooperate in Negatively Regulating Acute Inflammatory Responses

V. Kaartinen, D. Warburton, N. Heisterkamp, 2009, Molecular and Cellular Biology.

Use of bone marrow-derived macrophages to model murine innate immune responses.

N. Heisterkamp, J. Groffen, J. Cunnick, 2006, Journal of immunological methods.

Galectins and Pathologies: Role of Galectin-3 in the Communication between Leukemia Cells and the Microenvironment

N. Heisterkamp, J. Groffen, F. Fei, 2012 .

NOTES Evidence thatthephlGeneEncodes a160,000-Dalton Phosphoprotein withAssociated Kinase Activity

N. Heisterkamp, 1987 .

Expression of cassini, a murine gamma-satellite sequence conserved in evolution, is regulated in normal and malignant hematopoietic cells

N. Heisterkamp, J. Groffen, S. Yi, 2012, BMC Genomics.

Aspartylglycosaminuria in the Finnish population: identification of two point mutations in the heavy chain of glycoasparaginase.

L. Hood, J. Yates, V. Kaartinen, 1991, Proceedings of the National Academy of Sciences of the United States of America.

The human tyrosine kinase gene (FER) maps to chromosome 5 and is deleted in myeloid leukemias with a del(5q).

N. Heisterkamp, J. Groffen, J. Testa, 1990, Cytogenetics and cell genetics.

Overcoming Drug Resistance of Pre-B ALL Cells By Targeting Integrin alpha6 Associated Cell-Adhesion Mediated Drug Resistance Using a Novel Antibody, P5G10

N. Heisterkamp, E. Wayner, M. Müschen, 2015 .

The first BCR gene intron contains breakpoints in Philadelphia chromosome positive leukemia.

N. Heisterkamp, J. Groffen, E. Knoppel, 1988, Nucleic acids research.

Activity of the Bcr GTPase-activating Domain Is Regulated through Direct Protein/Protein Interaction with the Rho Guanine Nucleotide Dissociation Inhibitor*♦

N. Heisterkamp, J. Groffen, Y. Cho, 2008, Journal of Biological Chemistry.

Vestibular dysgenesis in mice lacking Abr and Bcr Cdc42/RacGAPs

V. Kaartinen, N. Heisterkamp, J. Groffen, 2002, Developmental dynamics : an official publication of the American Association of Anatomists.

ABR, an active BCR-related gene.

N. Heisterkamp, J. Groffen, C. Morris, 1989, Nucleic acids research.

TGFbeta3-induced activation of RhoA/Rho-kinase pathway is necessary but not sufficient for epithelio-mesenchymal transdifferentiation: implications for palatogenesis.

V. Kaartinen, N. Heisterkamp, J. Groffen, 2002, International journal of molecular medicine.

Identification of a novel Rac3-interacting protein C1D.

N. Heisterkamp, J. Groffen, L. Haataja, 1998, International journal of molecular medicine.

Targeting disordered-structured domain interactions in Galectin-3 based on NMR and enhanced MD.

Mingfeng Zhang, N. Heisterkamp, Weidong Hu, 2022, Biophysical journal.

The small GTPase Rac interacts with ubiquitination complex proteins Cullin-1 and CDC23.

N. Heisterkamp, J. Groffen, D. Senadheera, 2001, International journal of molecular medicine.

Phosphorylation substrates and altered signalling in leukemias caused by BCR/ABL

V. Kaartinen, N. Heisterkamp, J. Groffen, 1999, Leukemia.

Abnormal stress response and increased fighting behavior in mice lacking the bcr gene product.

J. Voncken, N. Heisterkamp, J. Groffen, 1998, International journal of molecular medicine.

Phenotypic characterization of mice with targeted disruption of glycosylasparaginase gene: A mouse model for aspartylglycosaminuria

V. Kaartinen, N. Heisterkamp, J. Groffen, 1998, Journal of Inherited Metabolic Disease.

Standpoint on imprinting of BCR and ABL.

T. Fioretos, N. Heisterkamp, J. Groffen, 1995, Leukemia.

Localization of a gamma-glutamyl-transferase-related gene family on chromosome 22

N. Heisterkamp, J. Groffen, C. Morris, 1993, Human Genetics.

Aspartylglycosaminuria in a non-Finnish patient caused by a donor splice mutation in the glycoasparaginase gene.

V. Kaartinen, N. Heisterkamp, J. Groffen, 1992, The Journal of biological chemistry.

A second hypervariable RFLP within the ABR gene.

N. Heisterkamp, J. Groffen, C. Morris, 1990, Nucleic acids research.

A hypervariable RFLP within the ABR gene.

N. Heisterkamp, J. Groffen, C. Morris, 1990, Nucleic acids research.

The c-abl oncogene in chronic myelogenous leukemia.

A. Hagemeijer, N. Heisterkamp, J. Groffen, 1987, Haematologica.

Deletion of c-fms sequences in the 5q- syndrome.

A. Ganser, N. Heisterkamp, J. Groffen, 1987, Leukemia.

The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading.

V. Kaartinen, N. Heisterkamp, J. Groffen, 2002, The Journal of biological chemistry.

Deletion within the D17S34 locus in a primitive neuroectodermal tumor.

D. Ledbetter, A. Tanigami, N. Heisterkamp, 1997, Cancer research.

Animal models for chronic myeloid leukemia and acute lymphoblastic leukemia.

J. Voncken, N. Heisterkamp, J. Groffen, 1992, Leukemia.

Adjuvant CD49d Blockade Eradicates Chemoresistant ALL

M. Loh, N. Heisterkamp, H. Koo, 2010 .

Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain.

N. Heisterkamp, J. Groffen, S. D. De Langhe, 2002, International journal of molecular medicine.

Sequence and analysis of the human ABL gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation.

S. Clifton, S. Chissoe, H. Pan, 1995, Genomics.

Targeting miR-126 in Ph+ acute lymphoblastic leukemia

N. Heisterkamp, L. Ghoda, G. Marcucci, 2023, Leukemia.

TGF-β3-null mutation does not abrogate fetal lung maturation in vivo by glucocorticoids.

V. Kaartinen, N. Heisterkamp, J. Groffen, 1999, American journal of physiology. Lung cellular and molecular physiology.

Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia.

M. Kahn, N. Heisterkamp, W. Hofmann, 2011, Blood.

Integrin alpha4 blockade sensitizes drug resistant pre-B acute lymphoblastic leukemia to chemotherapy.

N. Heisterkamp, H. Koo, W. Hofmann, 2013, Blood.

Bcr and Abr Cooperate in Negatively Regulating Acute Inflammatory Responses

V. Kaartinen, D. Warburton, N. Heisterkamp, 2009, Molecular and Cellular Biology.

Transforming growth factor‐β3 regulates transdifferentiation of medial edge epithelium during palatal fusion and associated degradation of the basement membrane

V. Kaartinen, C. Shuler, N. Heisterkamp, 1997 .

Transforming growth factor-beta3 regulates transdifferentiation of medial edge epithelium during palatal fusion and associated degradation of the basement membrane.

N. Heisterkamp, J. Groffen, X. Cui, 1997, Developmental dynamics : an official publication of the American Association of Anatomists.