B. Hug

发表

Structure and function of the murine β-globin locus control region 5′ HS-3

T. Ley, B. Hug, A. Moon, 1992 .

A randomized, crossover, placebo‐ and moxifloxacin‐controlled study to evaluate the effects of bosutinib (SKI‐606), a dual Src/Abl tyrosine kinase inhibitor, on cardiac repolarization in healthy adult subjects

B. Hug, D. Sonnichsen, R. Abbas, 2012, International journal of cancer.

A Single-Dose, Crossover, Placebo- and Moxifloxacin-Controlled Study to Assess the Effects of Neratinib (HKI-272) on Cardiac Repolarization in Healthy Adult Subjects

B. Hug, D. Sonnichsen, R. Abbas, 2010, Clinical Cancer Research.

Effect of Ketoconazole on the Pharmacokinetics of Oral Bosutinib in Healthy Subjects

B. Hug, D. Sonnichsen, R. Abbas, 2011, Journal of clinical pharmacology.

Phase 1 study of the BRAF inhibitor dabrafenib (D) with or without the MEK inhibitor trametinib (T) in combination with ipilimumab (Ipi) for V600E/K mutation–positive unresectable or metastatic melanoma (MM).

G. Linette, J. Wolchok, J. Sosman, 2014 .

A double-blind, randomized, multiple-dose, parallel-group study to characterize the occurrence of diarrhea following two different dosing regimens of neratinib, an irreversible pan-ErbB receptor tyrosine kinase inhibitor

B. Hug, D. Sonnichsen, R. Abbas, 2012, Cancer Chemotherapy and Pharmacology.

Pharmacokinetics of oral neratinib during co-administration of ketoconazole in healthy subjects.

B. Hug, D. Sonnichsen, R. Abbas, 2011, British journal of clinical pharmacology.

Intravenous temsirolimus in cancer patients: clinical pharmacology and dosing considerations.

B. Hug, J. Boni, D. Sonnichsen, 2009, Seminars in oncology.

Differential effects of ketoconazole on exposure to temsirolimus following intravenous infusion of temsirolimus

B. Hug, J. Boni, C. Leister, 2008, British Journal of Cancer.

Structure and function of the murine beta-globin locus control region 5' HS-3.

T. Ley, B. Hug, A. Moon, 1992, Nucleic acids research.

A single-dose placebo- and moxifloxacin-controlled study of the effects of temsirolimus on cardiac repolarization in healthy adults

B. Hug, J. Boni, D. Sonnichsen, 2012, Cancer Chemotherapy and Pharmacology.

Cooperative function of Aml1-ETO corepressor recruitment domains in the expansion of primary bone marrow cells.

B. Hug, M. Lazar, Jinsong Zhang, 2002, Cancer research.

HDAC4 A corepressor controlling bone development

B. Hug, 2004, Cell.

Pharmacokinetic Profile of Temsirolimus With Concomitant Administration of Cytochrome P450‐Inducing Medications 1

B. Hug, J. Boni, L. Moore, 2007, Journal of clinical pharmacology.

A phase I ascending single-dose study of the safety, tolerability, and pharmacokinetics of bosutinib (SKI-606) in healthy adult subjects

B. Hug, D. Sonnichsen, R. Abbas, 2011, Cancer Chemotherapy and Pharmacology.

Oligomerization of ETO Is Obligatory for Corepressor Interaction

B. Hug, S. Minucci, P. Pelicci, 2001, Molecular and Cellular Biology.

Independent formation of DnaseI hypersensitive sites in the murine beta-globin locus control region.

T. Ley, M. Groudine, A. Telling, 2000, Blood.

Analysis of Mice Containing a Targeted Deletion of (cid:98) -Globin Locus Control Region 5 (cid:57) Hypersensitive Site 3

T. Ley, M. Groudine, S. Fiering, 1996 .

Stochastic, stage-specific mechanisms account for the variegation of a human globin transgene.

T. Ley, B. Hug, T. Graubert, 1998, Nucleic acids research.

A Phase I, First‐in‐Human Study of GSK2849330, an Anti‐HER3 Monoclonal Antibody, in HER3‐Expressing Solid Tumors

A. Drilon, B. Hug, G. Ganji, 2021, The oncologist.

Analysis of mice containing a targeted deletion of beta-globin locus control region 5' hypersensitive site 3

T. Ley, M. Groudine, M. Bender, 1996, Molecular and cellular biology.

A Chromatin Immunoprecipitation Screen Reveals Protein Kinase Cβ as a Direct RUNX1 Target Gene*

B. Hug, M. Lazar, Mitchell A. Lazar, 2004, Journal of Biological Chemistry.

Long-range disruption of gene expression by a selectable marker cassette.

T. Ley, B. Hug, C. Pham, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Four-factor prothrombin complex concentrate versus plasma for rapid vitamin K antagonist reversal in patients needing urgent surgical or invasive interventions: a phase 3b, open-label, non-inferiority, randomised trial

B. Hug, J. Goldstein, T. Milling, 2015, The Lancet.

Deletions within the mouse β-globin locus control region preferentially reduce βmin globin gene expression.

T. Ley, M. Groudine, M. Bender, 2000 .

ETO interacting proteins

B. Hug, M. Lazar, Mitchell A Lazar, 2004, Oncogene.

Properties of human follicular dendritic cells purified with HJ2, a new monoclonal antibody.

B. Hug, A. Butch, M. Nahm, 1994, Cellular immunology.

Fusion-protein truncation provides new insights into leukemogenesis.

J. Hess, B. Hug, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Severe gastrointestinal toxicity with administration of trametinib in combination with dabrafenib and ipilimumab

Axel Hoos, B. Hug, I. Puzanov, 2015, Pigment cell & melanoma research.

RESEARCH NOTE

B. Hug, R. W. Tuveson, J. Rinkenberger, 1990 .

Growing Escherichia coli mutants deficient in riboflavin biosynthesis with non-limiting riboflavin results in sensitization to inactivation by broad-spectrum near-ultraviolet light (320-400 nm).

B. Hug, R. W. Tuveson, J. Rinkenberger, 1990, Photochemistry and photobiology.

Safety, Pharmacokinetics, and Pharmacodynamics of the TLR4 Agonist GSK1795091 in Healthy Individuals: Results from a Randomized, Double-blind, Placebo-controlled, Ascending Dose Study.

B. Hug, H. Struemper, C. Matheny, 2020, Clinical therapeutics.

Disposition of desipramine, a sensitive cytochrome P450 2D6 substrate, when coadministered with intravenous temsirolimus

B. Hug, J. Boni, R. Abbas, 2009, Cancer Chemotherapy and Pharmacology.

A phase I, open-label study of GSK1795091 administered in combination with immunotherapies in participants with advanced solid tumours (NCT03447314)

B. Hug, S. Piha-Paul, A. Hansen, 2019, Annals of Oncology.

Randomized Phase IIIb Study Of Rapid Vitamin K Antagonist Reversal In Patients Requiring An Urgent Surgical Procedure: Four-Factor Prothrombin Complex Concentrate Is Superior To Plasma

B. Hug, J. Goldstein, T. Milling, 2013 .

mTOR inhibition following a single intravenous infusion of temsirolimus in healthy individuals

B. Hug, J. Boni, D. Sonnichsen, 2007 .