K. Hoffmaster

发表

Membrane transporters in drug development

M. Niemi, Y. Sugiyama, K. Giacomini, 2010, Nature Reviews Drug Discovery.

Novel benzoxazole inhibitors of mPGES-1.

K. Hoffmaster, R. Nugent, M. Vazquez, 2013, Bioorganic & medicinal chemistry letters.

K. Hoffmaster, J. Xu, Jing Xu, 2010 .

Integration of hepatic drug transporters and phase II metabolizing enzymes: mechanisms of hepatic excretion of sulfate, glucuronide, and glutathione metabolites.

Kim L R Brouwer, K. Brouwer, K. Hoffmaster, 2006, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Design and synthesis of lactam-thiophene carboxylic acids as potent hepatitis C virus polymerase inhibitors.

Christopher T. Jones, K. Hoffmaster, Mitsunori Kato, 2014, Bioorganic & medicinal chemistry letters.

Liver tissue engineering in the evaluation of drug safety

Walker Inman, R Scott Obach, Linda G Griffith, 2009, Expert opinion on drug metabolism & toxicology.

MULTIPLE MECHANISMS ARE INVOLVED IN THE BILIARY EXCRETION OF ACETAMINOPHEN SULFATE IN THE RAT: ROLE OF MRP2 AND BCRP1

K. Brouwer, K. Hoffmaster, J. Polli, 2005, Drug Metabolism and Disposition.

Cytochrome P450 3A4 and P‐glycoprotein mediate the interaction between an oral erythromycin breath test and rifampin

P. Watkins, K. Hoffmaster, D. Wagner, 2002, Clinical pharmacology and therapeutics.

MULTIPLE TRANSPORT SYSTEMS MEDIATE THE HEPATIC UPTAKE AND BILIARY EXCRETION OF THE METABOLICALLY STABLE OPIOID PEPTIDE [d-PENICILLAMINE2,5]ENKEPHALIN

K. Brouwer, K. Hoffmaster, G. M. Pollack, 2005, Drug Metabolism and Disposition.

Hepatobiliary Disposition of a Drug/Metabolite Pair: Comprehensive Pharmacokinetic Modeling in Sandwich-Cultured Rat Hepatocytes

K. Brouwer, K. Hoffmaster, G. M. Pollack, 2006, Journal of Pharmacology and Experimental Therapeutics.

Apparent Differences in Mechanisms of Harmol Sulfate Biliary Excretion in Mice and Rats

K. Brouwer, K. Hoffmaster, K. Nezasa, 2008, Drug Metabolism and Disposition.

Inhibition of Dengue Virus through Suppression of Host Pyrimidine Biosynthesis

L. Kramer, P. Niyomrattanakit, K. Hoffmaster, 2011, Journal of Virology.

P-glycoprotein Expression, Localization, and Function in Sandwich-Cultured Primary Rat and Human Hepatocytes: Relevance to the

K. Brouwer, K. Hoffmaster, R. Kim, 2004 .

Mechanistic Insights of an Immunological Adverse Event Induced by an Anti-KIT Antibody Drug Conjugate and Mitigation Strategies

Anu V. Connor, J. Desai, K. Hoffmaster, 2018, Clinical Cancer Research.

Discovery of Small Molecule Splicing Modulators of Survival Motor Neuron-2 (SMN2) for the Treatment of Spinal Muscular Atrophy (SMA).

D. Curtis, M. Hild, Yiping Shen, 2018, Journal of medicinal chemistry.

Identification of broad-spectrum antiviral compounds and assessment of the druggability of their target for efficacy against respiratory syncytial virus (RSV)

John A. Tallarico, K. Kuhen, T. Bouwmeester, 2011, Proceedings of the National Academy of Sciences.

Implementation of pharmacokinetic and pharmacodynamic strategies in early research phases of drug discovery and development at Novartis Institute of Biomedical Research

Tove Tuntland, K. Hoffmaster, F. Blasco, 2014, Front. Pharmacol..

Automated sample preparation using membrane microtiter extraction for bioanalytical mass spectrometry.

K. Hoffmaster, P. Schneider, D. Wells, 1997, Rapid communications in mass spectrometry : RCM.

In Vitro Methods to Support Transporter Evaluation in Drug Discovery and Development

K. Brouwer, R. Evers, K. Hoffmaster, 2013, Clinical pharmacology and therapeutics.

SHP2 inhibition restores sensitivity in ALK-rearranged non-small-cell lung cancer resistant to ALK inhibitors

M. Lawrence, G. Caponigro, J. Engelman, 2018, Nature Medicine.

P-glycoprotein Expression, Localization, and Function in Sandwich-Cultured Primary Rat and Human Hepatocytes: Relevance to the Hepatobiliary Disposition of a Model Opioid Peptide

K. Brouwer, K. Hoffmaster, P. Meier, 2004, Pharmaceutical Research.

JPET #102616 HEPATOBILIARY DISPOSITION OF A DRUG/METABOLITE PAIR: COMPREHENSIVE PHARMACOKINETIC MODELING IN SANDWICH- CULTURED RAT HEPATOCYTES

K. Brouwer, K. Hoffmaster, J. C. Kalvass, 2006 .

Differential Involvement of Mrp2 (Abcc2) and Bcrp (Abcg2) in Biliary Excretion of 4-Methylumbelliferyl Glucuronide and Sulfate in the Rat

Kim L. R. Brouwer, K. Brouwer, K. Hoffmaster, 2006, Journal of Pharmacology and Experimental Therapeutics.

Current in vitro Models to Study Drug‐Induced Liver Injury

K. Hoffmaster, J. Xu, J. Davila, 2008 .

Highlights from the International Transporter Consortium Second Workshop

D. Tweedie, K. Hoffmaster, K. Giacomini, 2012, Clinical pharmacology and therapeutics.

Mechanisms of harmol sulfate biliary excretion in mice and rats

Brouwer, K. Hoffmaster, K. Nezasa, 2009 .

Hepatobiliary Disposition of the Metabolically Stable Opioid Peptide [d-Pen2, d-Pen5]-Enkephalin (DPDPE): Pharmacokinetic Consequences of the Interplay between Multiple Transport Systems

K. Brouwer, K. Hoffmaster, M. Zamek-Gliszczynski, 2004, Journal of Pharmacology and Experimental Therapeutics.

DMD # 1420 R Multiple Transport Systems Mediate the Hepatic Uptake and Biliary Excretion of the Metabolically Stable Opioid Peptide [ D-penicillamine 2 , 5 ] enkephalin

Brouwer, K. Hoffmaster, R. Kiml, 2004 .