Caroline A. Lee

发表

Membrane transporters in drug development

M. Niemi, Y. Sugiyama, K. Giacomini, 2010, Nature Reviews Drug Discovery.

Variability in P-Glycoprotein Inhibitory Potency (IC50) Using Various in Vitro Experimental Systems: Implications for Universal Digoxin Drug-Drug Interaction Risk Assessment Decision Criteria

M. Jamei, X. Chu, K. Hillgren, 2013, Drug Metabolism and Disposition.

Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study

W. Humphreys, X. Chu, Caroline A. Lee, 2018, Drug Metabolism and Disposition.

Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 6. Structure-activity studies of orally bioavailable, 2-pyridone-containing peptidomimetics.

Bo Liu, Rose Ann Ferre, Tove Tuntland, 2002, Journal of medicinal chemistry.

Drug–Drug Interactions Mediated Through P‐Glycoprotein: Clinical Relevance and In Vitro–In Vivo Correlation Using Digoxin as a Probe Drug

Caroline A. Lee, S. Kempshall, KS Fenner, 2009, Clinical pharmacology and therapeutics.

EVALUATION OF TIME-DEPENDENT INACTIVATION OF CYP3A IN CRYOPRESERVED HUMAN HEPATOCYTES

Caroline A. Lee, P. Zhao, K. Kunze, 2005, Drug Metabolism and Disposition.

Metabolism and disposition of lesinurad, a uric acid reabsorption inhibitor, in humans

Caroline A. Lee, Vishal D. Shah, Zancong Shen, 2018, Xenobiotica; the fate of foreign compounds in biological systems.

In Vitro Characterization of Axitinib Interactions with Human Efflux and Hepatic Uptake Transporters: Implications for Disposition and Drug Interactions

Caroline A. Lee, E. Reyner, M. Ullah, 2013, Drug Metabolism and Disposition.

Sequential Metabolism Is Responsible for Diltiazem-Induced Time-Dependent Loss of CYP3A

Caroline A. Lee, P. Zhao, K. Kunze, 2007, Drug Metabolism and Disposition.

In Vitro Assessment of the Drug–Drug Interaction Potential of Verinurad and Its Metabolites as Substrates and Inhibitors of Metabolizing Enzymes and Drug Transporters

Caroline A. Lee, T. Andersson, F. Erlandsson, 2021, The Journal of Pharmacology and Experimental Therapeutics.

Intestinal P‐gp and Putative Hepatic OATP1B Induction: International Transporter Consortium Perspective on Drug Development Implications

Y. Sugiyama, K. Brouwer, X. Chu, 2020, Clinical pharmacology and therapeutics.

Evaluation of Pharmacokinetic Interactions Between Lesinurad, a New Selective Urate Reabsorption Inhibitor, and Commonly Used Drugs for Gout Treatment

Caroline A. Lee, Zancong Shen, David M. Wilson, 2017, Clinical pharmacology in drug development.

Characterization of Stereoselective Metabolism, Inhibitory Effect on Uric Acid Uptake Transporters, and Pharmacokinetics of Lesinurad Atropisomers

Caroline A. Lee, M. Renner, J. Girardet, 2018, Drug Metabolism and Disposition.

Effect of Renal Impairment on the Pharmacokinetics and Pharmacodynamics of Verinurad, a Selective Uric Acid Reabsorption Inhibitor

Caroline A. Lee, T. Marbury, Zancong Shen, 2018, Clinical Drug Investigation.

Pharmacodynamic and pharmacokinetic effects and safety of verinurad in combination with febuxostat in adults with gout: a phase IIa, open-label study

Xiaohong Yan, Caroline A. Lee, R. Fleischmann, 2018, RMD Open.

Evaluation of Pharmacokinetic Interactions Between Lesinurad, a New Selective Urate Reabsorption Inhibitor, and CYP Enzyme Substrates Sildenafil, Amlodipine, Tolbutamide, and Repaglinide

Caroline A. Lee, Zancong Shen, David M. Wilson, 2017, Clinical pharmacology in drug development.

LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY AND LIQUID CHROMATOGRAPHY-NMR CHARACTERIZATION OF IN VITRO METABOLITES OF A POTENT AND IRREVERSIBLE PEPTIDOMIMETIC INHIBITOR OF RHINOVIRUS 3 C PROTEASE

Caroline A. Lee, B. Hee, B. Potts, 2001 .

Pharmacokinetics, Pharmacodynamics, and Tolerability of Concomitant Multiple Dose Administration of Verinurad (RDEA3170) and Allopurinol in Adult Male Subjects With Gout

Caroline A. Lee, J. Miner, Zancong Shen, 2018, Journal of clinical pharmacology.

Lesinurad: Evaluation of Pharmacokinetic and Pharmacodynamic Interactions With Warfarin in Healthy Volunteers

Caroline A. Lee, Zancong Shen, David M. Wilson, 2019, Clinical pharmacology in drug development.

Effects of Food and Antacids on Pharmacokinetics and Pharmacodynamics of Lesinurad, a Selective Urate Reabsorption Inhibitor

Caroline A. Lee, Zancong Shen, David M. Wilson, 2019, Clinical pharmacology in drug development.

Transporter-dependent cytotoxicity of antiviral drugs in primary cultures of human proximal tubular cells.

Caroline A. Lee, L. Lash, Vishal D. Shah, 2018, Toxicology.

Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 8. Pharmacological optimization of orally bioavailable 2-pyridone-containing peptidomimetics.

D. Matthews, P. Rejto, P. W. Rose, 2003, Journal of medicinal chemistry.

P-glycoprotein related drug interactions: clinical importance and a consideration of disease states

Caroline A. Lee, Dennis A. Smith, E. Reyner, 2010, Expert opinion on drug metabolism & toxicology.

Abundance of Drug Transporters in the Human Kidney Cortex as Quantified by Quantitative Targeted Proteomics

Caroline A. Lee, J. Himmelfarb, J. Unadkat, 2016, Drug Metabolism and Disposition.

Industry Perspective on Contemporary Protein-Binding Methodologies: Considerations for Regulatory Drug-Drug Interaction and Related Guidelines on Highly Bound Drugs.

Stacy Ho, Li Di, Avijit Ghosh, 2017, Journal of pharmaceutical sciences.

Utility of Genetically Modified Animal Models for Drug Metabolism and Drug Transporters

Caroline A. Lee, K. Youdim, A. Bessire, 2012 .

Solute Carrier (SLC) Family Transporters

Caroline A. Lee, J. Sahi, Y. Lai, 2012 .

Application of Receiver Operating Characteristic Analysis to Refine the Prediction of Potential Digoxin Drug Interactions

Sophie P. Chung, Shibing Deng, M. Jamei, 2013, Drug Metabolism and Disposition.

DMD050542 1367..1374

Sophie P. Chung, Shibing Deng, M. Jamei, 2013 .

Derivation of a System-Independent Ki for P-glycoprotein Mediated Digoxin Transport from System-Dependent IC50 Data

Caroline A. Lee, J. Bentz, H. Ellens, 2018, Drug Metabolism and Disposition.

Identification of Novel Substrates for Human Cytochrome P450 2J2

Caroline A. Lee, J. Jones, D. Dalvie, 2010, Drug Metabolism and Disposition.

Breast Cancer Resistance Protein (ABCG2) in Clinical Pharmacokinetics and Drug Interactions: Practical Recommendations for Clinical Victim and Perpetrator Drug-Drug Interaction Study Design

Caroline A. Lee, J. Polli, J. Ware, 2015, Drug Metabolism and Disposition.

MECHANISM OF CYTOCHROME P 450 ACTIVATION BY CAFFEINE AND 7 , 8-BENZOFLAVONE IN RAT LIVER MICROSOMES

Caroline A. Lee, S. Nelson, K. Thummel, 1997 .

Microsoft Word-39120393-file00.docx

Caroline A. Lee, E. Reyner, M. Ullah, 2013 .

ITC Commentary on Metformin Clinical Drug–Drug Interaction Study Design That Enables an Efficacy‐ and Safety‐Based Dose Adjustment Decision

K. Giacomini, X. Chu, Caroline A. Lee, 2018, Clinical pharmacology and therapeutics.

Effects of renal function on pharmacokinetics and pharmacodynamics of lesinurad in adult volunteers

Caroline A. Lee, M. Gillen, B. Kerr, 2016, Drug design, development and therapy.

Metabolism and Disposition of Verinurad, a Uric Acid Reabsorption Inhibitor, in Humans

Caroline A. Lee, David M. Wilson, Vishal D. Shah, 2018, Drug Metabolism and Disposition.

Supratherapeutic dose evaluation and effect of lesinurad on cardiac repolarization: a thorough QT/QTc study

Caroline A. Lee, David M. Wilson, M. Gillen, 2016, Drug design, development and therapy.

Development of a new permeability assay using low-efflux MDCKII cells.

Li Di, Bo Feng, Hui Zhang, 2011, Journal of pharmaceutical sciences.

Development of an in vitro drug-drug interaction assay to simultaneously monitor five cytochrome P450 isoforms and performance assessment using drug library compounds.

Caroline A. Lee, Douglas Burdette, R. Hyland, 2008, Journal of pharmacological and toxicological methods.

Rosuvastatin pharmacokinetics and pharmacogenetics in white and Asian subjects residing in the same environment

Caroline A. Lee, Yusong Chen, E. Lee, 2005, Clinical pharmacology and therapeutics.

Transporter Expression in Noncancerous and Cancerous Liver Tissue from Donors with Hepatocellular Carcinoma and Chronic Hepatitis C Infection Quantified by LC-MS/MS Proteomics

W. Humphreys, X. Chu, R. Evers, 2018, Drug Metabolism and Disposition.

Transporter Expression in Liver Tissue from Subjects with Alcoholic or Hepatitis C Cirrhosis Quantified by Targeted Quantitative Proteomics

Li Wang, Carol Collins, Cornelis E. C. A. Hop, 2016, Drug Metabolism and Disposition.

Identifying a Selective Substrate and Inhibitor Pair for the Evaluation of CYP2J2 Activity

G. S. Walker, Caroline A. Lee, J. Jones, 2012, Drug Metabolism and Disposition.

Refining the in vitro and in vivo critical parameters for P-glycoprotein, [I]/IC50 and [I2]/IC50, that allow for the exclusion of drug candidates from clinical digoxin interaction studies.

Bo Feng, Ray Liu, Jack A Cook, 2010, Molecular pharmaceutics.

Digoxin Is Not a Substrate for Organic Anion-Transporting Polypeptide Transporters OATP1A2, OATP1B1, OATP1B3, and OATP2B1 but Is a Substrate for a Sodium-Dependent Transporter Expressed in HEK293 Cells

Mitchell E Taub, Harma Ellens, Caroline A. Lee, 2011, Drug Metabolism and Disposition.

Running Title : Digoxin and OATP

Caroline A. Lee, H. Ellens, R. Sane, 2011 .

Identification of Novel Substrates for Human Cytochrome P450 2J2

Caroline A. Lee, D. Dalvie, M. Wester, 2010, Drug Metabolism and Disposition.

Response from the International Transporter Consortium

K. Hillgren, Caroline A. Lee, J. Polli, 2010, Nature Reviews Drug Discovery.

A novel application of t-statistics to objectively assess the quality of IC50 fits for P-glycoprotein and other transporters

Michael O'Connor, Caroline Lee, Harma Ellens, 2014, Pharmacology research & perspectives.

In Vitro Characterization of Axitinib Interactions with Human Efflux and Hepatic Uptake Transporters: Implications for Disposition and Drug Interactions

Caroline A. Lee, E. Reyner, M. Ullah, 2013, Drug Metabolism and Disposition.

Breast Cancer Resistance Protein (ABCG2) in Clinical Pharmacokinetics and Drug Interactions: Practical Recommendations for Clinical Victim and Perpetrator Drug-Drug Interaction Study Design

Caroline A. Lee, J. Polli, J. Ware, 2015, Drug Metabolism and Disposition.

Lack of Respiratory and Contact Sensitizing Potential of the Intranasal Antiviral Drug Candidate Rupintrivir (AG7088): A Weight-of-the-Evidence Evaluation

Caroline A. Lee, W. Evering, S. Webber, 2005, Journal of immunotoxicology.